SIMILAR PATTERNS OF AMINO ACIDS FOR 3DH0_A_SAMA220_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)

(Sulfolobus
solfataricus) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 LYS O 172
ARG O 166
GLU O  39
GLU O 173
 SO4  O 610 (-2.6A)
SO4  O 603 ( 3.3A)
SO4  O 610 ( 4.3A)
SO4  O 610 (-4.2A)
 1.40A 3dh0A-1b7gO:
4.7		 3dh0A-1b7gO:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emu AXIN

(Homo sapiens) 		PF00615
(RGS) 		4 ARG A 174
ASP A 220
GLN A 223
GLU A 225
 None
 1.31A 3dh0A-1emuA:
undetectable		 3dh0A-1emuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 LYS A 105
ARG A  71
TYR A  45
ASP A  99
 None
CL  A 362 (-4.8A)
None
None
 1.35A 3dh0A-1ezwA:
undetectable		 3dh0A-1ezwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TYR A 242
GLN A 620
MET A 541
GLU A 214
 None
 1.43A 3dh0A-1g8kA:
3.1		 3dh0A-1g8kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LYS A 268
ARG A 337
MET A 234
GLU A  82
 None
 1.10A 3dh0A-1hplA:
2.1		 3dh0A-1hplA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 ARG A 195
ASP A 398
GLN A 392
GLU A 541
 None
 1.33A 3dh0A-1iwpA:
undetectable		 3dh0A-1iwpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 134
GLN A  50
MET A 327
GLU A 121
 None
None
None
CL  A 541 ( 4.2A)
 1.37A 3dh0A-1knrA:
2.4		 3dh0A-1knrA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 LYS A 324
TYR A  26
GLU A 251
GLU A 314
 None
 1.21A 3dh0A-1lrwA:
undetectable		 3dh0A-1lrwA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 313
ARG A 405
GLN A 319
GLU A 117
 None
 1.39A 3dh0A-1opkA:
undetectable		 3dh0A-1opkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LYS A 268
ARG A 337
MET A 234
GLU A  82
 None
 1.02A 3dh0A-1rp1A:
2.1		 3dh0A-1rp1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 ARG A 314
MET A 276
GLU A  25
GLU A  22
 None
 1.20A 3dh0A-1uc4A:
undetectable		 3dh0A-1uc4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		4 ARG A 164
ASP A  49
MET A  50
GLU A  95
 None
 1.39A 3dh0A-1wozA:
undetectable		 3dh0A-1wozA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		4 LYS A 318
ASP A 310
MET A 307
GLU A 322
 None
 1.41A 3dh0A-1ydxA:
undetectable		 3dh0A-1ydxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 TYR A 128
ASP A 222
GLN A 224
GLU A 309
 None
 1.43A 3dh0A-1yrgA:
undetectable		 3dh0A-1yrgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 TYR A 223
ASP A 256
GLN A 255
GLU A 288
 None
 0.96A 3dh0A-2bx7A:
undetectable		 3dh0A-2bx7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 ARG A1133
TYR A1068
GLU A1162
GLU A1155
 None
 1.43A 3dh0A-2c3oA:
2.6		 3dh0A-2c3oA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LYS A 256
TYR A 188
MET A 250
GLU A 257
 None
 1.30A 3dh0A-2cw7A:
undetectable		 3dh0A-2cw7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8;
Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		4 TYR B  26
ASP B  30
GLU A  33
GLU A  48
 None
 1.30A 3dh0A-2dppB:
undetectable		 3dh0A-2dppB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 ARG A 295
MET A 165
GLU A 202
GLU A 291
 None
None
ADP  A 501 (-4.1A)
ADP  A 501 (-3.2A)
 1.26A 3dh0A-2dwcA:
3.4		 3dh0A-2dwcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 LYS A  19
ASP A  86
GLU A  53
GLU A  18
 None
 1.30A 3dh0A-2eb5A:
undetectable		 3dh0A-2eb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 698
ASP A 816
GLU A 812
GLU A 791
 None
 1.38A 3dh0A-2faqA:
undetectable		 3dh0A-2faqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqs PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Escherichia
coli) 		PF01259
(SAICAR_synt) 		4 LYS A 123
ARG A  94
ASP A  36
GLU A  90
 ADP  A 238 ( 2.7A)
C2R  A 242 (-3.1A)
MG  A 240 (-4.6A)
MG  A 240 ( 2.4A)
 1.23A 3dh0A-2gqsA:
undetectable		 3dh0A-2gqsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ARG A 558
ASP A 197
GLN A 196
GLU A 190
 None
 1.24A 3dh0A-2i1jA:
undetectable		 3dh0A-2i1jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdj REDY-LIKE PROTEIN

(Hahella
chejuensis) 		PF11639
(HapK) 		4 ASP A  68
MET A  71
GLU A   2
GLU A  92
 None
 1.44A 3dh0A-2jdjA:
undetectable		 3dh0A-2jdjA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ARG A 327
TYR A 165
ASP A 297
GLN A 319
 None
 1.44A 3dh0A-2jisA:
undetectable		 3dh0A-2jisA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		4 LYS A  99
ASP A  54
GLN A  50
GLU A  95
 None
 1.44A 3dh0A-2masA:
5.1		 3dh0A-2masA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A 880
ASP A 615
GLU A1072
GLU A 858
 None
 1.40A 3dh0A-2np0A:
undetectable		 3dh0A-2np0A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 LYS A 224
ARG A 558
GLN A 226
GLU A 413
 None
 1.44A 3dh0A-2odpA:
2.4		 3dh0A-2odpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 ASP A 198
GLN A 186
GLU A 191
GLU A 658
 None
 1.06A 3dh0A-2po4A:
undetectable		 3dh0A-2po4A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LYS A 245
ARG A 193
TYR A 236
GLU A 278
 None
 1.30A 3dh0A-2q6zA:
undetectable		 3dh0A-2q6zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqy SIGMA B OPERON

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 ARG A 136
ASP A 126
GLU A  19
GLU A  94
 None
 1.17A 3dh0A-2qqyA:
undetectable		 3dh0A-2qqyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		4 TYR A 132
ASP A 141
GLU A 145
GLU A 172
 None
 1.41A 3dh0A-2rfgA:
undetectable		 3dh0A-2rfgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdf OUTER MEMBRANE
PROTEIN

(Neisseria
meningitidis) 		PF07239
(OpcA) 		4 TYR A  96
ASP A 144
GLU A 208
GLU A   9
 None
 1.27A 3dh0A-2vdfA:
undetectable		 3dh0A-2vdfA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 LYS A 155
ARG A 126
ASP A 225
GLU A 237
 None
 1.39A 3dh0A-2vj5A:
undetectable		 3dh0A-2vj5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 ARG A 144
TYR A 146
GLU A 238
GLU A 273
 None
UNX  A1287 ( 4.6A)
None
None
 1.32A 3dh0A-2x2uA:
undetectable		 3dh0A-2x2uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xeh NI3C MUT6

(synthetic
construct) 		PF12796
(Ank_2) 		4 ARG A  89
TYR A  81
GLU A  20
GLU A  57
 SO4  A1170 ( 3.0A)
SO4  A1171 (-4.4A)
None
None
 1.31A 3dh0A-2xehA:
undetectable		 3dh0A-2xehA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 ASP A 122
GLN A 114
GLU A 150
GLU A 451
 None
 1.12A 3dh0A-2z23A:
undetectable		 3dh0A-2z23A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 439
GLN A 435
MET A 438
GLU A 374
 None
 1.34A 3dh0A-3b96A:
undetectable		 3dh0A-3b96A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 ARG A 133
TYR A   6
GLN A 110
MET A 122
 None
 1.18A 3dh0A-3bhwA:
undetectable		 3dh0A-3bhwA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		4 LYS K 193
ARG K 129
MET K 178
GLU K 314
 None
 1.17A 3dh0A-3ci0K:
undetectable		 3dh0A-3ci0K:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ARG A 157
ASP A  75
GLN A  72
GLU A  69
 None
 1.28A 3dh0A-3cmmA:
5.3		 3dh0A-3cmmA:
11.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		8 LYS A   6
ARG A  20
TYR A  51
ASP A  69
GLN A  71
MET A  74
GLU A  97
GLU A 118
 SAM  A 220 (-2.9A)
SAM  A 220 (-2.9A)
SAM  A 220 (-3.8A)
SAM  A 220 (-3.0A)
SAM  A 220 (-4.1A)
SAM  A 220 (-4.2A)
SAM  A 220 (-3.2A)
SAM  A 220 (-3.3A)
 0.01A 3dh0A-3dh0A:
39.9		 3dh0A-3dh0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Rhodobacter
sphaeroides) 		PF01323
(DSBA) 		4 ARG A  36
TYR A  95
ASP A 103
GLU A  23
 None
 1.27A 3dh0A-3fz5A:
undetectable		 3dh0A-3fz5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 296
MET A 225
GLU A 247
GLU A 298
 None
 1.36A 3dh0A-3gdeA:
undetectable		 3dh0A-3gdeA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica) 		PF03063
(Prismane)
PF03598
(CdhC) 		4 ARG A 194
TYR A 674
GLN M  42
GLU M  37
 None
 1.37A 3dh0A-3i04A:
2.7		 3dh0A-3i04A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A  58
ASP A 199
GLU A 385
GLU A 177
 None
ZN  A 411 (-1.9A)
None
ZN  A 412 (-2.2A)
 1.24A 3dh0A-3ifeA:
undetectable		 3dh0A-3ifeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ARG A 201
ASP A  19
GLN A  17
GLU A  34
 None
 0.97A 3dh0A-3muoA:
undetectable		 3dh0A-3muoA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 TYR A 623
GLN A 697
GLU A 638
GLU A 646
 None
 1.33A 3dh0A-3n9oA:
undetectable		 3dh0A-3n9oA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		4 LYS A 109
TYR A 220
ASP A 236
GLN A 239
 None
PGE  A 321 ( 3.4A)
None
None
 1.27A 3dh0A-3o66A:
undetectable		 3dh0A-3o66A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot2 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF05685
(Uma2) 		4 LYS A  34
GLN A 116
GLU A  67
GLU A  25
 None
 1.17A 3dh0A-3ot2A:
undetectable		 3dh0A-3ot2A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 TYR A 323
GLN A 311
GLU A 372
GLU A 263
 None
 1.38A 3dh0A-3pieA:
2.9		 3dh0A-3pieA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ARG A 630
TYR A 312
ASP A 506
GLU A 541
 None
 1.40A 3dh0A-3pvcA:
11.1		 3dh0A-3pvcA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ARG A1233
ASP A1321
GLU A1327
GLU A1248
 None
 1.27A 3dh0A-3pvlA:
undetectable		 3dh0A-3pvlA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 TYR M 338
ASP M  84
GLN M  62
GLU M 208
 None
 1.43A 3dh0A-3rkoM:
undetectable		 3dh0A-3rkoM:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		4 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 FBP  A 350 ( 2.6A)
None
MG  A 348 (-3.3A)
MG  A 347 ( 3.4A)
 1.30A 3dh0A-3rplA:
undetectable		 3dh0A-3rplA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ARG A 557
ASP A 902
GLU A 659
GLU A 221
 None
 1.35A 3dh0A-3sfzA:
undetectable		 3dh0A-3sfzA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 261
ARG A 292
GLN A 439
GLU A 774
 None
 1.40A 3dh0A-4a2pA:
3.0		 3dh0A-4a2pA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ARG A 380
TYR A 392
GLN A 342
GLU A 350
 None
 1.22A 3dh0A-4b0nA:
undetectable		 3dh0A-4b0nA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		4 ARG A 109
TYR A 185
ASP A 212
GLU A 102
 None
 1.29A 3dh0A-4b8sA:
3.8		 3dh0A-4b8sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ASP A 337
MET A 148
GLU A 415
GLU A 205
 None
 0.83A 3dh0A-4bevA:
2.3		 3dh0A-4bevA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 LYS A 240
TYR A 451
ASP A 478
GLU A 159
 None
 1.43A 3dh0A-4c90A:
undetectable		 3dh0A-4c90A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 ASP B 373
GLN B 385
MET B 382
GLU B 368
 None
 1.09A 3dh0A-4e54B:
undetectable		 3dh0A-4e54B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g92 HAPB PROTEIN
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE

(Aspergillus
nidulans;
Aspergillus
nidulans;
Aspergillus
nidulans) 		PF02045
(CBFB_NFYA)
PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 TYR A 235
ASP C 153
GLN C  54
GLU B 117
 None
 1.39A 3dh0A-4g92A:
undetectable		 3dh0A-4g92A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 556
GLN A 618
GLU A 625
GLU A 481
 None
 1.31A 3dh0A-4gf2A:
undetectable		 3dh0A-4gf2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 TYR A 230
ASP A 338
GLU A 317
GLU A 305
 None
 1.44A 3dh0A-4ggpA:
5.3		 3dh0A-4ggpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 ARG A 299
ASP A 465
GLN A 468
GLU A 450
 None
 1.13A 3dh0A-4jrnA:
undetectable		 3dh0A-4jrnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 LYS A 169
ARG A  42
GLN A 199
GLU A 172
 None
 1.25A 3dh0A-4knaA:
3.1		 3dh0A-4knaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		4 TYR A 168
ASP A 143
GLU A  81
GLU A  44
 None
None
MG  A 303 ( 2.4A)
None
 1.27A 3dh0A-4l7wA:
undetectable		 3dh0A-4l7wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae) 		PF08787
(Alginate_lyase2) 		4 TYR A 202
GLN A 282
GLU A  95
GLU A 169
 None
 1.09A 3dh0A-4ozxA:
undetectable		 3dh0A-4ozxA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 ARG A 637
ASP A 450
GLN A 835
GLU A 842
 None
 1.15A 3dh0A-4q2cA:
3.0		 3dh0A-4q2cA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ARG A 569
ASP A 197
GLN A 196
GLU A 190
 None
 1.14A 3dh0A-4rm9A:
undetectable		 3dh0A-4rm9A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ASP A 127
GLN A 114
GLU A 117
GLU A 550
 None
 1.33A 3dh0A-4rmfA:
undetectable		 3dh0A-4rmfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuk DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 LYS B 419
ARG B 678
GLN B 416
MET B 670
 None
 1.43A 3dh0A-4uukB:
undetectable		 3dh0A-4uukB:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LYS A 407
ARG A 688
ASP A 353
GLU A 314
 None
 1.33A 3dh0A-4uzsA:
undetectable		 3dh0A-4uzsA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens;
Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2)
no annotation 		4 LYS C1109
ASP A 764
MET A 761
GLU A 744
 None
 1.35A 3dh0A-4z96C:
undetectable		 3dh0A-4z96C:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LYS A 380
TYR A 273
ASP A 251
GLN A 354
 None
 1.45A 3dh0A-4zr1A:
undetectable		 3dh0A-4zr1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		4 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 VTB  A1339 (-3.2A)
None
MG  A1341 (-2.8A)
MG  A1342 (-3.0A)
 1.42A 3dh0A-5a5lA:
undetectable		 3dh0A-5a5lA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox) 		4 ARG A 735
ASP A 741
GLN A 664
GLU A 617
 LMR  A1760 (-2.9A)
None
None
LMR  A1760 ( 4.7A)
 1.22A 3dh0A-5apaA:
undetectable		 3dh0A-5apaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens;
Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
no annotation 		4 LYS C 657
ASP A 764
MET A 761
GLU A 744
 LYS  C 657 ( 0.0A)
ASP  A 764 ( 0.6A)
MET  A 761 ( 0.0A)
GLU  A 744 ( 0.6A)
 1.42A 3dh0A-5c6dC:
undetectable		 3dh0A-5c6dC:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ARG A 464
TYR A 469
ASP A 136
GLU A 146
 None
 1.25A 3dh0A-5cwaA:
undetectable		 3dh0A-5cwaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A  23
ASP A  67
GLU A  70
GLU A 234
 None
 1.34A 3dh0A-5enyA:
undetectable		 3dh0A-5enyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 ARG A1151
ASP A1239
GLU A1245
GLU A1166
 None
 1.20A 3dh0A-5f3yA:
undetectable		 3dh0A-5f3yA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 160
TYR A 158
ASP A 225
GLN A 264
 None
 1.36A 3dh0A-5fp1A:
undetectable		 3dh0A-5fp1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 TYR A  74
ASP A 134
GLN A 139
GLU A 163
 None
ACY  A 402 (-3.4A)
None
None
 1.43A 3dh0A-5hcfA:
undetectable		 3dh0A-5hcfA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		4 ARG B 416
TYR B 439
ASP A 268
GLN A 244
 None
 1.28A 3dh0A-5hftB:
undetectable		 3dh0A-5hftB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		4 ASP A 147
GLN A 113
MET A 153
GLU A 119
 None
 1.09A 3dh0A-5jqnA:
undetectable		 3dh0A-5jqnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LYS A 491
ARG A 141
GLN A 425
GLU A 621
 None
 1.10A 3dh0A-5jxrA:
2.1		 3dh0A-5jxrA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 ARG A 863
TYR A 792
ASP A 912
GLN A 915
 None
 1.28A 3dh0A-5kdxA:
undetectable		 3dh0A-5kdxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 4 ARG A 298
GLN A 360
GLU A 463
GLU A 350
 None
 1.35A 3dh0A-5ohxA:
undetectable		 3dh0A-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ARG A 119
ASP A 669
GLU A 196
GLU A 194
 None
 1.05A 3dh0A-5oljA:
undetectable		 3dh0A-5oljA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		4 LYS E 192
GLN E 209
GLU E 226
GLU E 193
 None
 1.29A 3dh0A-5t9cE:
undetectable		 3dh0A-5t9cE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 680
ASP A 640
GLN A 647
GLU A 649
 None
 1.38A 3dh0A-5vywA:
undetectable		 3dh0A-5vywA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 ARG A 187
ASP A 371
GLN A 370
MET A 104
 None
 1.24A 3dh0A-5wblA:
undetectable		 3dh0A-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 ARG A 192
GLN A 238
GLU A 335
GLU A 200
 None
 1.35A 3dh0A-5wp4A:
18.5		 3dh0A-5wp4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A 266
TYR A 223
GLN A 164
GLU A 245
 None
 1.40A 3dh0A-5xfmA:
undetectable		 3dh0A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE
RIBOSOMAL PROTEIN
S14
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis;
Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7)
PF00411
(Ribosomal_S11)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 ARG O 129
GLN c   7
GLU F 186
GLU c  59
 None
 1.37A 3dh0A-5xyiO:
undetectable		 3dh0A-5xyiO:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yix RNA POLYMERASE SIGMA
FACTOR RPOD

(Caulobacter
vibrioides) 		no annotation 4 ASP A 266
GLN A 265
GLU A 259
GLU A 160
 None
 1.11A 3dh0A-5yixA:
undetectable		 3dh0A-5yixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 4 TYR A 397
GLN A 468
GLU A 291
GLU A 365
 None
 1.17A 3dh0A-5zu5A:
undetectable		 3dh0A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 ARG A  40
ASP A  73
MET A  74
GLU A 326
 None
GOL  A 408 ( 4.3A)
GOL  A 407 (-4.1A)
None
 1.38A 3dh0A-6bqcA:
14.8		 3dh0A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 LYS A 164
TYR A 502
MET A 396
GLU A 473
 None
 1.33A 3dh0A-6f5dA:
2.6		 3dh0A-6f5dA:
undetectable