SIMILAR PATTERNS OF AMINO ACIDS FOR 3DH0_A_SAMA220

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		5 VAL A 199
GLY A 200
GLY A 202
ALA A 230
LEU A 133
 None
 1.02A 3dh0A-12asA:
undetectable		 3dh0A-12asA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A  94
VAL A  38
ALA A 278
THR A 275
LEU A 271
 None
 1.24A 3dh0A-1b0aA:
4.5		 3dh0A-1b0aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9k ACIDIC LECTIN

(Psophocarpus
tetragonolobus) 		PF00139
(Lectin_legB) 		5 GLY A  89
ALA A  87
PHE A 127
THR A 126
LEU A 155
 None
AMG  A 400 ( 3.7A)
AMG  A 400 ( 3.6A)
None
None
 0.59A 3dh0A-1f9kA:
undetectable		 3dh0A-1f9kA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  52
VAL A  25
ALA A 168
PHE A 169
THR A 170
 None
 1.28A 3dh0A-1fnoA:
undetectable		 3dh0A-1fnoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzc ERYTHRINA
CRISTA-GALLI LECTIN

(Erythrina
crista-galli) 		PF00139
(Lectin_legB) 		5 GLY A  90
ALA A  88
PHE A 131
THR A 130
LEU A 160
 None
LAT  A1559 ( 3.8A)
LAT  A1559 ( 3.7A)
None
None
 0.72A 3dh0A-1gzcA:
undetectable		 3dh0A-1gzcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		5 VAL A  25
GLY A  26
PHE A 113
VAL A  41
ALA A 117
 None
 1.33A 3dh0A-1mivA:
undetectable		 3dh0A-1mivA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		5 GLY A 431
GLY A  83
PHE A 501
THR A 497
LEU A 473
 None
 1.21A 3dh0A-1obhA:
undetectable		 3dh0A-1obhA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 LEU A 149
VAL A 162
GLY A 161
GLY A 159
THR A  92
 None
 1.25A 3dh0A-1qleA:
undetectable		 3dh0A-1qleA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbd SOYBEAN AGGLUTININ

(Glycine max) 		PF00139
(Lectin_legB) 		5 GLY A  89
ALA A  87
PHE A 128
THR A 127
LEU A 156
 None
GAL  A 847 ( 4.4A)
GAL  A 847 (-4.0A)
None
None
 0.98A 3dh0A-1sbdA:
undetectable		 3dh0A-1sbdA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A 246
GLY A 178
GLY A 180
PHE A 243
LEU A 282
 None
PLP  A 413 (-3.3A)
PLP  A 413 (-3.5A)
None
None
 1.03A 3dh0A-1ve5A:
2.4		 3dh0A-1ve5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		5 LEU A 310
VAL A 206
GLY A 263
THR A 323
LEU A 106
 None
 0.88A 3dh0A-1vffA:
undetectable		 3dh0A-1vffA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 VAL A 292
GLY A 291
GLY A 349
THR A 352
LEU A 344
 ATP  A 504 (-4.9A)
ATP  A 504 ( 4.7A)
None
ATP  A 504 (-4.1A)
None
 1.31A 3dh0A-1y8pA:
undetectable		 3dh0A-1y8pA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 239
GLY A 234
GLY A 238
ALA A 232
LEU A 320
 None
 1.14A 3dh0A-1yj8A:
6.7		 3dh0A-1yj8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 VAL A 616
GLY A 617
GLY A 619
THR A 428
LEU A 655
 None
 0.91A 3dh0A-2b8eA:
3.5		 3dh0A-2b8eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7t BASIC AGGLUTININ

(Psophocarpus
tetragonolobus) 		PF00139
(Lectin_legB) 		5 GLY A  88
ALA A  86
PHE A 126
THR A 125
LEU A 154
 None
A2G  A 400 ( 4.3A)
A2G  A 400 ( 3.8A)
None
None
 0.67A 3dh0A-2e7tA:
undetectable		 3dh0A-2e7tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 VAL A 160
GLY A 163
GLY A  55
SER A  82
THR A 158
 None
FAD  A1625 (-3.1A)
FAD  A1625 (-3.3A)
None
None
 1.38A 3dh0A-2f5vA:
undetectable		 3dh0A-2f5vA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 VAL A  44
GLY A  45
GLY A  47
PHE A 103
THR A 105
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.5A)
 0.81A 3dh0A-2gs9A:
17.5		 3dh0A-2gs9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 PHE A  85
LEU A  24
GLY A  15
GLY A  21
LEU A  67
 None
 1.40A 3dh0A-2hrzA:
3.9		 3dh0A-2hrzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 VAL A  72
GLY A 131
VAL A 381
ALA A 408
LEU A 441
 None
 1.14A 3dh0A-2oodA:
undetectable		 3dh0A-2oodA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484

(Clavularia sp.) 		PF01353
(GFP) 		5 PHE A  65
LEU A  46
GLY A  33
GLY A  31
SER A 117
 None
 1.38A 3dh0A-2otbA:
undetectable		 3dh0A-2otbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 VAL A 214
GLY A 213
GLY A 142
VAL A 137
ALA A 102
 None
 1.30A 3dh0A-2pi5A:
undetectable		 3dh0A-2pi5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 LEU A 574
GLY A 608
PHE A 591
VAL A 424
LEU A 626
 None
 1.30A 3dh0A-2pziA:
undetectable		 3dh0A-2pziA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhs LIPOYLTRANSFERASE

(Thermus
thermophilus) 		PF03099
(BPL_LplA_LipB) 		5 GLY A 152
GLY A 141
SER A 149
ALA A 154
LEU A  36
 OCA  A3913 (-4.3A)
OCA  A3913 (-3.9A)
None
OCA  A3913 ( 4.1A)
None
 1.40A 3dh0A-2qhsA:
undetectable		 3dh0A-2qhsA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU B 590
VAL B 581
GLY B 580
GLY B 578
PHE B 592
 None
 1.23A 3dh0A-2qy0B:
undetectable		 3dh0A-2qy0B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 666
GLY A 613
VAL A 611
ALA A 615
LEU A 686
 None
 1.09A 3dh0A-2v9yA:
undetectable		 3dh0A-2v9yA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 VAL I 616
GLY I 617
GLY I 619
THR I 428
LEU I 655
 None
 0.91A 3dh0A-2voyI:
3.4		 3dh0A-2voyI:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x75 ADENYLOSUCCINATE
LYASE

(Staphylococcus
aureus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLY A 178
GLY A 205
SER A 210
PHE A 104
THR A 100
 None
 1.26A 3dh0A-2x75A:
undetectable		 3dh0A-2x75A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 PHE B 337
GLY B  28
VAL B 166
ALA B 147
LEU B 143
 None
 1.19A 3dh0A-2yevB:
undetectable		 3dh0A-2yevB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 GLY A 145
GLY A 279
PHE A 141
PHE A 291
LEU A 177
 PLP  A1446 (-3.2A)
None
None
None
None
 1.18A 3dh0A-2ykyA:
undetectable		 3dh0A-2ykyA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 VAL A 298
GLY A 297
GLY A 355
THR A 358
LEU A 350
 ADP  A 501 (-4.7A)
ADP  A 501 ( 4.6A)
None
ADP  A 501 (-3.8A)
None
 1.34A 3dh0A-2zkjA:
undetectable		 3dh0A-2zkjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 VAL A 167
GLY A 166
SER A 161
ALA A 199
THR A 210
 None
 1.23A 3dh0A-3cj1A:
undetectable		 3dh0A-3cj1A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		12 PHE A   7
LEU A  15
VAL A  44
GLY A  45
GLY A  47
PHE A  50
VAL A  70
SER A  95
ALA A 113
PHE A 114
THR A 115
LEU A 119
 None
SAM  A 220 (-4.0A)
SAM  A 220 ( 4.8A)
SAM  A 220 (-3.5A)
SAM  A 220 ( 3.7A)
None
SAM  A 220 ( 4.1A)
SAM  A 220 ( 3.7A)
SAM  A 220 (-3.9A)
None
SAM  A 220 (-4.1A)
SAM  A 220 (-4.6A)
 0.03A 3dh0A-3dh0A:
39.9		 3dh0A-3dh0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 LEU A  17
GLY A   7
GLY A  13
ALA A  31
LEU A  89
 None
 1.02A 3dh0A-3dqpA:
5.5		 3dh0A-3dqpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 311
GLY A 307
GLY A 309
THR A 331
LEU A 349
 None
FAB  A 701 (-3.2A)
FAB  A 701 (-3.4A)
FAB  A 701 (-2.9A)
None
 1.41A 3dh0A-3e9yA:
2.7		 3dh0A-3e9yA:
17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		5 GLY A  88
GLY A  90
VAL A 112
SER A 136
ALA A 155
 None
 0.88A 3dh0A-3evzA:
15.9		 3dh0A-3evzA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 277
GLY A 280
PHE A 256
SER A 154
ALA A 273
 None
 1.20A 3dh0A-3gg9A:
5.4		 3dh0A-3gg9A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klq PUTATIVE PILUS
ANCHORING PROTEIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		5 PHE A  24
LEU A  15
GLY A  46
VAL A  11
SER A  10
 None
 1.20A 3dh0A-3klqA:
undetectable		 3dh0A-3klqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1y PHOSPHOSERINE
PHOSPHATASE (SERB)

(Helicobacter
pylori) 		PF00702
(Hydrolase) 		5 VAL A 162
GLY A 163
GLY A 165
THR A  12
LEU A 200
 None
 1.02A 3dh0A-3m1yA:
2.5		 3dh0A-3m1yA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9i LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		5 PHE A 136
VAL A 206
GLY A 207
GLY A 211
THR A 131
 None
 1.37A 3dh0A-3m9iA:
undetectable		 3dh0A-3m9iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		5 PHE A 296
LEU A 310
GLY A 357
PHE A 355
SER A 429
 None
 1.19A 3dh0A-3ogzA:
2.2		 3dh0A-3ogzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		5 VAL A 292
PHE A 354
VAL A 321
ALA A 294
LEU A  48
 None
EPE  A 409 (-3.8A)
None
HEM  A 501 ( 3.8A)
None
 1.35A 3dh0A-3p3lA:
undetectable		 3dh0A-3p3lA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 GLY A 229
VAL A 232
ALA A 191
THR A 194
LEU A 196
 None
 1.17A 3dh0A-3t57A:
undetectable		 3dh0A-3t57A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 VAL A   6
GLY A   7
GLY A   9
VAL A  39
LEU A 138
 None
 0.67A 3dh0A-3u95A:
4.1		 3dh0A-3u95A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 527
GLY A 575
VAL A 564
THR A 337
LEU A 459
 None
 1.17A 3dh0A-3ue3A:
undetectable		 3dh0A-3ue3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		5 LEU A 252
VAL A 248
GLY A 249
GLY A 333
THR A 190
 None
 1.38A 3dh0A-3vilA:
undetectable		 3dh0A-3vilA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 217
GLY A 218
PHE A 158
VAL A 223
SER A 230
 None
None
None
None
PEG  A1325 (-3.4A)
 1.39A 3dh0A-4bgvA:
7.6		 3dh0A-4bgvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 LEU A 380
GLY A 324
GLY A 322
VAL A 365
THR A 326
 None
JHZ  A 504 (-3.6A)
None
None
JHZ  A 504 (-4.0A)
 1.22A 3dh0A-4e2zA:
14.5		 3dh0A-4e2zA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 GLY A 270
GLY A 267
SER A 372
ALA A 244
LEU A 258
 None
None
None
GOL  A 407 ( 4.2A)
None
 0.91A 3dh0A-4evqA:
undetectable		 3dh0A-4evqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f07 STYRENE
MONOOXYGENASE
COMPONENT 2

(Pseudomonas sp.
Y2) 		PF01613
(Flavin_Reduct) 		5 PHE A  76
LEU A  70
GLY A  41
VAL A  39
LEU A 114
 None
 1.12A 3dh0A-4f07A:
undetectable		 3dh0A-4f07A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 GLY A 282
GLY A 286
PHE A  13
VAL A  71
LEU A 209
 None
 1.22A 3dh0A-4g1uA:
undetectable		 3dh0A-4g1uA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		5 LEU A  36
GLY A  39
GLY A  37
VAL A  54
LEU A 287
 None
NDP  A 401 (-3.4A)
None
None
NDP  A 401 (-4.3A)
 1.35A 3dh0A-4ijrA:
undetectable		 3dh0A-4ijrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PHE A 267
GLY A 365
GLY A 363
PHE A 359
SER A 312
 NO2  A 501 (-3.4A)
None
None
None
None
 1.21A 3dh0A-4jreA:
undetectable		 3dh0A-4jreA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 LEU A 142
GLY A 122
GLY A 120
ALA A 126
LEU A  99
 None
 1.02A 3dh0A-4lk5A:
undetectable		 3dh0A-4lk5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi) 		no annotation 5 LEU A 292
GLY A 291
PHE A 241
PHE A 124
THR A 125
 None
 0.98A 3dh0A-4lt5A:
undetectable		 3dh0A-4lt5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 LEU A  27
VAL A 133
GLY A 111
GLY A  64
LEU A 150
 None
 1.32A 3dh0A-4olqA:
undetectable		 3dh0A-4olqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 PHE A 876
VAL A 866
GLY A 867
GLY A 873
ALA A 896
 None
 1.24A 3dh0A-4pj6A:
undetectable		 3dh0A-4pj6A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 212
VAL A 114
GLY A 184
PHE A 275
ALA A 181
 None
 1.15A 3dh0A-4q05A:
3.2		 3dh0A-4q05A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		5 PHE A 356
LEU A 331
VAL A 191
SER A 189
LEU A 392
 None
 1.00A 3dh0A-4q76A:
2.4		 3dh0A-4q76A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 VAL A 177
GLY A 178
GLY A 180
ALA A 244
LEU A 258
 None
 1.09A 3dh0A-4qvgA:
17.6		 3dh0A-4qvgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		5 LEU A 102
GLY A 304
VAL A 309
ALA A 300
LEU A 263
 LMT  A 802 ( 4.1A)
LMT  A 806 ( 4.5A)
None
None
None
 0.92A 3dh0A-4r0cA:
undetectable		 3dh0A-4r0cA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		5 VAL A  13
GLY A  14
GLY A  16
VAL A  42
LEU A 227
 FAD  A 502 (-4.5A)
FAD  A 502 (-3.6A)
FAD  A 502 (-4.2A)
FAD  A 502 (-4.9A)
FAD  A 502 (-4.2A)
 0.89A 3dh0A-4rslA:
2.7		 3dh0A-4rslA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		5 VAL A  13
GLY A  14
GLY A  17
VAL A  42
LEU A 227
 FAD  A 502 (-4.5A)
FAD  A 502 (-3.6A)
FAD  A 502 (-3.1A)
FAD  A 502 (-4.9A)
FAD  A 502 (-4.2A)
 1.09A 3dh0A-4rslA:
2.7		 3dh0A-4rslA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 PHE A 278
VAL A 312
GLY A 313
GLY A 341
ALA A 338
 None
 1.31A 3dh0A-4um8A:
undetectable		 3dh0A-4um8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urp FATTY ACID
REPRESSION MUTANT
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00881
(Nitroreductase) 		5 LEU A  20
VAL A  59
GLY A  92
VAL A  94
LEU A  30
 None
 1.15A 3dh0A-4urpA:
undetectable		 3dh0A-4urpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 GLY A  28
VAL A  63
SER A  61
ALA A  26
LEU A 248
 None
 1.28A 3dh0A-4y96A:
undetectable		 3dh0A-4y96A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 LEU A 129
VAL A 184
GLY A 185
GLY A 189
LEU A 113
 None
 1.18A 3dh0A-4z8zA:
undetectable		 3dh0A-4z8zA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A  71
VAL A 103
GLY A 104
GLY A  94
LEU A 131
 None
 0.97A 3dh0A-4zrsA:
undetectable		 3dh0A-4zrsA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		5 GLY A 570
GLY A 615
VAL A 599
THR A 401
LEU A 512
 NHE  A 901 (-3.6A)
NHE  A 901 ( 4.7A)
None
None
None
 1.21A 3dh0A-4ztkA:
undetectable		 3dh0A-4ztkA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 VAL A  91
GLY A  92
GLY A  96
THR A 319
LEU A 337
 None
 0.94A 3dh0A-5b58A:
undetectable		 3dh0A-5b58A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 LEU A 133
VAL A  72
GLY A  73
GLY A  77
PHE A 130
 None
 1.36A 3dh0A-5c65A:
undetectable		 3dh0A-5c65A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg9 TET-LIKE DIOXYGENASE

(Naegleria
gruberi) 		no annotation 5 LEU A 292
GLY A 291
PHE A 241
PHE A 124
THR A 125
 None
 0.96A 3dh0A-5cg9A:
undetectable		 3dh0A-5cg9A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLY A 911
PHE A 823
PHE A 805
THR A 804
LEU A 134
 None
None
None
EDO  A1604 ( 4.7A)
None
 1.14A 3dh0A-5dotA:
2.2		 3dh0A-5dotA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 VAL A 166
GLY A 165
GLY A 163
ALA A 192
LEU A 125
 None
 0.66A 3dh0A-5dtrA:
11.9		 3dh0A-5dtrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 5 GLY A 106
ALA A  67
PHE A 103
THR A 105
LEU A 116
 None
 1.34A 3dh0A-5eyiA:
undetectable		 3dh0A-5eyiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 161
VAL A 307
SER A 227
THR A 250
LEU A 282
 None
 1.09A 3dh0A-5fkcA:
undetectable		 3dh0A-5fkcA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 PHE A 675
LEU A 654
GLY A 615
ALA A 613
THR A 616
 None
 1.35A 3dh0A-5fkrA:
undetectable		 3dh0A-5fkrA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		5 GLY A 954
GLY A 486
VAL A 949
PHE A 959
LEU A 829
 None
 1.15A 3dh0A-5fswA:
undetectable		 3dh0A-5fswA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU C 358
GLY C 353
GLY C 357
SER C 308
ALA C 351
 None
 1.20A 3dh0A-5g5gC:
undetectable		 3dh0A-5g5gC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 GLY E 159
GLY E 180
PHE E 185
VAL E 164
ALA E 155
 None
 1.30A 3dh0A-5h36E:
undetectable		 3dh0A-5h36E:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		5 PHE A 514
LEU A 587
GLY A 536
PHE A 588
VAL A 582
 None
 1.41A 3dh0A-5h3oA:
undetectable		 3dh0A-5h3oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF) 		5 LEU A 102
VAL A  84
GLY A  85
PHE A 103
THR A  88
 None
 1.01A 3dh0A-5iaaA:
5.3		 3dh0A-5iaaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 VAL A 341
GLY A 342
GLY A 344
THR A 191
LEU A 379
 None
 0.87A 3dh0A-5it0A:
2.0		 3dh0A-5it0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 PHE A  62
GLY A  74
VAL A  89
ALA A 132
PHE A 145
 None
 1.21A 3dh0A-5jheA:
undetectable		 3dh0A-5jheA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 PHE A 518
VAL A 515
GLY A 516
GLY A 499
THR A 534
 None
 1.30A 3dh0A-5kshA:
undetectable		 3dh0A-5kshA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 PHE A 518
VAL A 515
GLY A 516
GLY A 545
THR A 534
 None
 1.33A 3dh0A-5kshA:
undetectable		 3dh0A-5kshA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 LEU A  39
GLY A 605
GLY A  38
ALA A 607
THR A 602
 None
 1.14A 3dh0A-5mq6A:
3.4		 3dh0A-5mq6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE

(Mus musculus) 		no annotation 5 LEU A  11
GLY A  36
GLY A  34
ALA A  49
PHE A  86
 None
8DG  A 204 (-3.4A)
None
None
None
 1.21A 3dh0A-5mzeA:
undetectable		 3dh0A-5mzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbo GLYCOSYL HYDROLASE
FAMILY 16

(Bacteroides
ovatus) 		no annotation 5 GLY A 150
GLY A 154
VAL A 164
THR A 120
LEU A 117
 None
 1.03A 3dh0A-5nboA:
undetectable		 3dh0A-5nboA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 VAL A  38
GLY A  39
GLY A  95
PHE A 129
SER A 407
 None
 1.22A 3dh0A-5neuA:
undetectable		 3dh0A-5neuA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A 128
VAL A  72
ALA A 328
THR A 324
LEU A 320
 None
 1.38A 3dh0A-5tc4A:
undetectable		 3dh0A-5tc4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		5 LEU A  88
VAL A  59
GLY A  60
GLY A  62
ALA A  84
 None
FAD  A 501 (-4.7A)
FAD  A 501 (-3.1A)
FAD  A 501 (-3.5A)
FAD  A 501 (-3.3A)
 1.38A 3dh0A-5ttkA:
undetectable		 3dh0A-5ttkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLY A  44
GLY A  49
VAL A 128
ALA A  93
LEU A 115
 None
 1.32A 3dh0A-5um6A:
4.0		 3dh0A-5um6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 LEU A  61
GLY A 116
ALA A 123
THR A 121
LEU A 172
 NAD  A 301 (-4.3A)
None
None
None
None
 1.26A 3dh0A-5vn2A:
6.7		 3dh0A-5vn2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 VAL A 148
GLY A 149
GLY A 291
ALA A 145
THR A 150
 None
 1.15A 3dh0A-5vyeA:
2.6		 3dh0A-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 VAL A 289
GLY A 290
GLY A 292
PHE A 262
THR A 357
 None
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
None
SAH  A 703 (-3.2A)
 0.90A 3dh0A-5wp4A:
18.5		 3dh0A-5wp4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 LEU A  17
GLY A   8
GLY A  14
ALA A  30
LEU A 116
 None
 1.13A 3dh0A-5wqnA:
7.8		 3dh0A-5wqnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE

(Chromobacterium
sp. USM2) 		PF07167
(PhaC_N) 		5 PHE A 214
LEU A 288
VAL A 292
GLY A 293
GLY A 289
 None
 1.26A 3dh0A-5xavA:
2.2		 3dh0A-5xavA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 LEU A  14
GLY A   8
GLY A  10
SER A 155
LEU A 147
 None
FAD  A 501 (-3.3A)
FAD  A 501 (-3.4A)
None
None
 1.23A 3dh0A-6c7sA:
3.4		 3dh0A-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA

(Norwalk virus) 		no annotation 5 GLY B 115
ALA B 117
PHE B 118
THR B 119
LEU B 190
 None
 1.12A 3dh0A-6crjB:
undetectable		 3dh0A-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 5 LEU F  48
VAL F 390
GLY F 387
GLY F  44
LEU F  76
 None
 1.30A 3dh0A-6f0kF:
undetectable		 3dh0A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)

(Sulfolobus
solfataricus) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 LYS O 172
ARG O 166
GLU O  39
GLU O 173
 SO4  O 610 (-2.6A)
SO4  O 603 ( 3.3A)
SO4  O 610 ( 4.3A)
SO4  O 610 (-4.2A)
 1.40A 3dh0A-1b7gO:
4.7		 3dh0A-1b7gO:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emu AXIN

(Homo sapiens) 		PF00615
(RGS) 		4 ARG A 174
ASP A 220
GLN A 223
GLU A 225
 None
 1.31A 3dh0A-1emuA:
undetectable		 3dh0A-1emuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 LYS A 105
ARG A  71
TYR A  45
ASP A  99
 None
CL  A 362 (-4.8A)
None
None
 1.35A 3dh0A-1ezwA:
undetectable		 3dh0A-1ezwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TYR A 242
GLN A 620
MET A 541
GLU A 214
 None
 1.43A 3dh0A-1g8kA:
3.1		 3dh0A-1g8kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LYS A 268
ARG A 337
MET A 234
GLU A  82
 None
 1.10A 3dh0A-1hplA:
2.1		 3dh0A-1hplA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 ARG A 195
ASP A 398
GLN A 392
GLU A 541
 None
 1.33A 3dh0A-1iwpA:
undetectable		 3dh0A-1iwpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 134
GLN A  50
MET A 327
GLU A 121
 None
None
None
CL  A 541 ( 4.2A)
 1.37A 3dh0A-1knrA:
2.4		 3dh0A-1knrA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 LYS A 324
TYR A  26
GLU A 251
GLU A 314
 None
 1.21A 3dh0A-1lrwA:
undetectable		 3dh0A-1lrwA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 313
ARG A 405
GLN A 319
GLU A 117
 None
 1.39A 3dh0A-1opkA:
undetectable		 3dh0A-1opkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LYS A 268
ARG A 337
MET A 234
GLU A  82
 None
 1.02A 3dh0A-1rp1A:
2.1		 3dh0A-1rp1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 ARG A 314
MET A 276
GLU A  25
GLU A  22
 None
 1.20A 3dh0A-1uc4A:
undetectable		 3dh0A-1uc4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		4 ARG A 164
ASP A  49
MET A  50
GLU A  95
 None
 1.39A 3dh0A-1wozA:
undetectable		 3dh0A-1wozA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		4 LYS A 318
ASP A 310
MET A 307
GLU A 322
 None
 1.41A 3dh0A-1ydxA:
undetectable		 3dh0A-1ydxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 TYR A 128
ASP A 222
GLN A 224
GLU A 309
 None
 1.43A 3dh0A-1yrgA:
undetectable		 3dh0A-1yrgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 TYR A 223
ASP A 256
GLN A 255
GLU A 288
 None
 0.96A 3dh0A-2bx7A:
undetectable		 3dh0A-2bx7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 ARG A1133
TYR A1068
GLU A1162
GLU A1155
 None
 1.43A 3dh0A-2c3oA:
2.6		 3dh0A-2c3oA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LYS A 256
TYR A 188
MET A 250
GLU A 257
 None
 1.30A 3dh0A-2cw7A:
undetectable		 3dh0A-2cw7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8;
Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		4 TYR B  26
ASP B  30
GLU A  33
GLU A  48
 None
 1.30A 3dh0A-2dppB:
undetectable		 3dh0A-2dppB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 ARG A 295
MET A 165
GLU A 202
GLU A 291
 None
None
ADP  A 501 (-4.1A)
ADP  A 501 (-3.2A)
 1.26A 3dh0A-2dwcA:
3.4		 3dh0A-2dwcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 LYS A  19
ASP A  86
GLU A  53
GLU A  18
 None
 1.30A 3dh0A-2eb5A:
undetectable		 3dh0A-2eb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 698
ASP A 816
GLU A 812
GLU A 791
 None
 1.38A 3dh0A-2faqA:
undetectable		 3dh0A-2faqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqs PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Escherichia
coli) 		PF01259
(SAICAR_synt) 		4 LYS A 123
ARG A  94
ASP A  36
GLU A  90
 ADP  A 238 ( 2.7A)
C2R  A 242 (-3.1A)
MG  A 240 (-4.6A)
MG  A 240 ( 2.4A)
 1.23A 3dh0A-2gqsA:
undetectable		 3dh0A-2gqsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ARG A 558
ASP A 197
GLN A 196
GLU A 190
 None
 1.24A 3dh0A-2i1jA:
undetectable		 3dh0A-2i1jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdj REDY-LIKE PROTEIN

(Hahella
chejuensis) 		PF11639
(HapK) 		4 ASP A  68
MET A  71
GLU A   2
GLU A  92
 None
 1.44A 3dh0A-2jdjA:
undetectable		 3dh0A-2jdjA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ARG A 327
TYR A 165
ASP A 297
GLN A 319
 None
 1.44A 3dh0A-2jisA:
undetectable		 3dh0A-2jisA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		4 LYS A  99
ASP A  54
GLN A  50
GLU A  95
 None
 1.44A 3dh0A-2masA:
5.1		 3dh0A-2masA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A 880
ASP A 615
GLU A1072
GLU A 858
 None
 1.40A 3dh0A-2np0A:
undetectable		 3dh0A-2np0A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 LYS A 224
ARG A 558
GLN A 226
GLU A 413
 None
 1.44A 3dh0A-2odpA:
2.4		 3dh0A-2odpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 ASP A 198
GLN A 186
GLU A 191
GLU A 658
 None
 1.06A 3dh0A-2po4A:
undetectable		 3dh0A-2po4A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LYS A 245
ARG A 193
TYR A 236
GLU A 278
 None
 1.30A 3dh0A-2q6zA:
undetectable		 3dh0A-2q6zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqy SIGMA B OPERON

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 ARG A 136
ASP A 126
GLU A  19
GLU A  94
 None
 1.17A 3dh0A-2qqyA:
undetectable		 3dh0A-2qqyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		4 TYR A 132
ASP A 141
GLU A 145
GLU A 172
 None
 1.41A 3dh0A-2rfgA:
undetectable		 3dh0A-2rfgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdf OUTER MEMBRANE
PROTEIN

(Neisseria
meningitidis) 		PF07239
(OpcA) 		4 TYR A  96
ASP A 144
GLU A 208
GLU A   9
 None
 1.27A 3dh0A-2vdfA:
undetectable		 3dh0A-2vdfA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 LYS A 155
ARG A 126
ASP A 225
GLU A 237
 None
 1.39A 3dh0A-2vj5A:
undetectable		 3dh0A-2vj5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 ARG A 144
TYR A 146
GLU A 238
GLU A 273
 None
UNX  A1287 ( 4.6A)
None
None
 1.32A 3dh0A-2x2uA:
undetectable		 3dh0A-2x2uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xeh NI3C MUT6

(synthetic
construct) 		PF12796
(Ank_2) 		4 ARG A  89
TYR A  81
GLU A  20
GLU A  57
 SO4  A1170 ( 3.0A)
SO4  A1171 (-4.4A)
None
None
 1.31A 3dh0A-2xehA:
undetectable		 3dh0A-2xehA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 ASP A 122
GLN A 114
GLU A 150
GLU A 451
 None
 1.12A 3dh0A-2z23A:
undetectable		 3dh0A-2z23A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 439
GLN A 435
MET A 438
GLU A 374
 None
 1.34A 3dh0A-3b96A:
undetectable		 3dh0A-3b96A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 ARG A 133
TYR A   6
GLN A 110
MET A 122
 None
 1.18A 3dh0A-3bhwA:
undetectable		 3dh0A-3bhwA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		4 LYS K 193
ARG K 129
MET K 178
GLU K 314
 None
 1.17A 3dh0A-3ci0K:
undetectable		 3dh0A-3ci0K:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ARG A 157
ASP A  75
GLN A  72
GLU A  69
 None
 1.28A 3dh0A-3cmmA:
5.3		 3dh0A-3cmmA:
11.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		8 LYS A   6
ARG A  20
TYR A  51
ASP A  69
GLN A  71
MET A  74
GLU A  97
GLU A 118
 SAM  A 220 (-2.9A)
SAM  A 220 (-2.9A)
SAM  A 220 (-3.8A)
SAM  A 220 (-3.0A)
SAM  A 220 (-4.1A)
SAM  A 220 (-4.2A)
SAM  A 220 (-3.2A)
SAM  A 220 (-3.3A)
 0.01A 3dh0A-3dh0A:
39.9		 3dh0A-3dh0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Rhodobacter
sphaeroides) 		PF01323
(DSBA) 		4 ARG A  36
TYR A  95
ASP A 103
GLU A  23
 None
 1.27A 3dh0A-3fz5A:
undetectable		 3dh0A-3fz5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 296
MET A 225
GLU A 247
GLU A 298
 None
 1.36A 3dh0A-3gdeA:
undetectable		 3dh0A-3gdeA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica) 		PF03063
(Prismane)
PF03598
(CdhC) 		4 ARG A 194
TYR A 674
GLN M  42
GLU M  37
 None
 1.37A 3dh0A-3i04A:
2.7		 3dh0A-3i04A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A  58
ASP A 199
GLU A 385
GLU A 177
 None
ZN  A 411 (-1.9A)
None
ZN  A 412 (-2.2A)
 1.24A 3dh0A-3ifeA:
undetectable		 3dh0A-3ifeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ARG A 201
ASP A  19
GLN A  17
GLU A  34
 None
 0.97A 3dh0A-3muoA:
undetectable		 3dh0A-3muoA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 TYR A 623
GLN A 697
GLU A 638
GLU A 646
 None
 1.33A 3dh0A-3n9oA:
undetectable		 3dh0A-3n9oA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		4 LYS A 109
TYR A 220
ASP A 236
GLN A 239
 None
PGE  A 321 ( 3.4A)
None
None
 1.27A 3dh0A-3o66A:
undetectable		 3dh0A-3o66A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot2 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF05685
(Uma2) 		4 LYS A  34
GLN A 116
GLU A  67
GLU A  25
 None
 1.17A 3dh0A-3ot2A:
undetectable		 3dh0A-3ot2A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 TYR A 323
GLN A 311
GLU A 372
GLU A 263
 None
 1.38A 3dh0A-3pieA:
2.9		 3dh0A-3pieA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ARG A 630
TYR A 312
ASP A 506
GLU A 541
 None
 1.40A 3dh0A-3pvcA:
11.1		 3dh0A-3pvcA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ARG A1233
ASP A1321
GLU A1327
GLU A1248
 None
 1.27A 3dh0A-3pvlA:
undetectable		 3dh0A-3pvlA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 TYR M 338
ASP M  84
GLN M  62
GLU M 208
 None
 1.43A 3dh0A-3rkoM:
undetectable		 3dh0A-3rkoM:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		4 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 FBP  A 350 ( 2.6A)
None
MG  A 348 (-3.3A)
MG  A 347 ( 3.4A)
 1.30A 3dh0A-3rplA:
undetectable		 3dh0A-3rplA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ARG A 557
ASP A 902
GLU A 659
GLU A 221
 None
 1.35A 3dh0A-3sfzA:
undetectable		 3dh0A-3sfzA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 261
ARG A 292
GLN A 439
GLU A 774
 None
 1.40A 3dh0A-4a2pA:
3.0		 3dh0A-4a2pA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ARG A 380
TYR A 392
GLN A 342
GLU A 350
 None
 1.22A 3dh0A-4b0nA:
undetectable		 3dh0A-4b0nA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		4 ARG A 109
TYR A 185
ASP A 212
GLU A 102
 None
 1.29A 3dh0A-4b8sA:
3.8		 3dh0A-4b8sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ASP A 337
MET A 148
GLU A 415
GLU A 205
 None
 0.83A 3dh0A-4bevA:
2.3		 3dh0A-4bevA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 LYS A 240
TYR A 451
ASP A 478
GLU A 159
 None
 1.43A 3dh0A-4c90A:
undetectable		 3dh0A-4c90A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 ASP B 373
GLN B 385
MET B 382
GLU B 368
 None
 1.09A 3dh0A-4e54B:
undetectable		 3dh0A-4e54B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g92 HAPB PROTEIN
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE

(Aspergillus
nidulans;
Aspergillus
nidulans;
Aspergillus
nidulans) 		PF02045
(CBFB_NFYA)
PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 TYR A 235
ASP C 153
GLN C  54
GLU B 117
 None
 1.39A 3dh0A-4g92A:
undetectable		 3dh0A-4g92A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 556
GLN A 618
GLU A 625
GLU A 481
 None
 1.31A 3dh0A-4gf2A:
undetectable		 3dh0A-4gf2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 TYR A 230
ASP A 338
GLU A 317
GLU A 305
 None
 1.44A 3dh0A-4ggpA:
5.3		 3dh0A-4ggpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 ARG A 299
ASP A 465
GLN A 468
GLU A 450
 None
 1.13A 3dh0A-4jrnA:
undetectable		 3dh0A-4jrnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 LYS A 169
ARG A  42
GLN A 199
GLU A 172
 None
 1.25A 3dh0A-4knaA:
3.1		 3dh0A-4knaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		4 TYR A 168
ASP A 143
GLU A  81
GLU A  44
 None
None
MG  A 303 ( 2.4A)
None
 1.27A 3dh0A-4l7wA:
undetectable		 3dh0A-4l7wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae) 		PF08787
(Alginate_lyase2) 		4 TYR A 202
GLN A 282
GLU A  95
GLU A 169
 None
 1.09A 3dh0A-4ozxA:
undetectable		 3dh0A-4ozxA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 ARG A 637
ASP A 450
GLN A 835
GLU A 842
 None
 1.15A 3dh0A-4q2cA:
3.0		 3dh0A-4q2cA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ARG A 569
ASP A 197
GLN A 196
GLU A 190
 None
 1.14A 3dh0A-4rm9A:
undetectable		 3dh0A-4rm9A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ASP A 127
GLN A 114
GLU A 117
GLU A 550
 None
 1.33A 3dh0A-4rmfA:
undetectable		 3dh0A-4rmfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuk DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 LYS B 419
ARG B 678
GLN B 416
MET B 670
 None
 1.43A 3dh0A-4uukB:
undetectable		 3dh0A-4uukB:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LYS A 407
ARG A 688
ASP A 353
GLU A 314
 None
 1.33A 3dh0A-4uzsA:
undetectable		 3dh0A-4uzsA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens;
Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2)
no annotation 		4 LYS C1109
ASP A 764
MET A 761
GLU A 744
 None
 1.35A 3dh0A-4z96C:
undetectable		 3dh0A-4z96C:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LYS A 380
TYR A 273
ASP A 251
GLN A 354
 None
 1.45A 3dh0A-4zr1A:
undetectable		 3dh0A-4zr1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		4 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 VTB  A1339 (-3.2A)
None
MG  A1341 (-2.8A)
MG  A1342 (-3.0A)
 1.42A 3dh0A-5a5lA:
undetectable		 3dh0A-5a5lA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox) 		4 ARG A 735
ASP A 741
GLN A 664
GLU A 617
 LMR  A1760 (-2.9A)
None
None
LMR  A1760 ( 4.7A)
 1.22A 3dh0A-5apaA:
undetectable		 3dh0A-5apaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens;
Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
no annotation 		4 LYS C 657
ASP A 764
MET A 761
GLU A 744
 LYS  C 657 ( 0.0A)
ASP  A 764 ( 0.6A)
MET  A 761 ( 0.0A)
GLU  A 744 ( 0.6A)
 1.42A 3dh0A-5c6dC:
undetectable		 3dh0A-5c6dC:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ARG A 464
TYR A 469
ASP A 136
GLU A 146
 None
 1.25A 3dh0A-5cwaA:
undetectable		 3dh0A-5cwaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A  23
ASP A  67
GLU A  70
GLU A 234
 None
 1.34A 3dh0A-5enyA:
undetectable		 3dh0A-5enyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 ARG A1151
ASP A1239
GLU A1245
GLU A1166
 None
 1.20A 3dh0A-5f3yA:
undetectable		 3dh0A-5f3yA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 160
TYR A 158
ASP A 225
GLN A 264
 None
 1.36A 3dh0A-5fp1A:
undetectable		 3dh0A-5fp1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 TYR A  74
ASP A 134
GLN A 139
GLU A 163
 None
ACY  A 402 (-3.4A)
None
None
 1.43A 3dh0A-5hcfA:
undetectable		 3dh0A-5hcfA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		4 ARG B 416
TYR B 439
ASP A 268
GLN A 244
 None
 1.28A 3dh0A-5hftB:
undetectable		 3dh0A-5hftB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		4 ASP A 147
GLN A 113
MET A 153
GLU A 119
 None
 1.09A 3dh0A-5jqnA:
undetectable		 3dh0A-5jqnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LYS A 491
ARG A 141
GLN A 425
GLU A 621
 None
 1.10A 3dh0A-5jxrA:
2.1		 3dh0A-5jxrA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 ARG A 863
TYR A 792
ASP A 912
GLN A 915
 None
 1.28A 3dh0A-5kdxA:
undetectable		 3dh0A-5kdxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 4 ARG A 298
GLN A 360
GLU A 463
GLU A 350
 None
 1.35A 3dh0A-5ohxA:
undetectable		 3dh0A-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ARG A 119
ASP A 669
GLU A 196
GLU A 194
 None
 1.05A 3dh0A-5oljA:
undetectable		 3dh0A-5oljA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		4 LYS E 192
GLN E 209
GLU E 226
GLU E 193
 None
 1.29A 3dh0A-5t9cE:
undetectable		 3dh0A-5t9cE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 680
ASP A 640
GLN A 647
GLU A 649
 None
 1.38A 3dh0A-5vywA:
undetectable		 3dh0A-5vywA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 ARG A 187
ASP A 371
GLN A 370
MET A 104
 None
 1.24A 3dh0A-5wblA:
undetectable		 3dh0A-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 ARG A 192
GLN A 238
GLU A 335
GLU A 200
 None
 1.35A 3dh0A-5wp4A:
18.5		 3dh0A-5wp4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A 266
TYR A 223
GLN A 164
GLU A 245
 None
 1.40A 3dh0A-5xfmA:
undetectable		 3dh0A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE
RIBOSOMAL PROTEIN
S14
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis;
Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7)
PF00411
(Ribosomal_S11)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 ARG O 129
GLN c   7
GLU F 186
GLU c  59
 None
 1.37A 3dh0A-5xyiO:
undetectable		 3dh0A-5xyiO:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yix RNA POLYMERASE SIGMA
FACTOR RPOD

(Caulobacter
vibrioides) 		no annotation 4 ASP A 266
GLN A 265
GLU A 259
GLU A 160
 None
 1.11A 3dh0A-5yixA:
undetectable		 3dh0A-5yixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 4 TYR A 397
GLN A 468
GLU A 291
GLU A 365
 None
 1.17A 3dh0A-5zu5A:
undetectable		 3dh0A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 ARG A  40
ASP A  73
MET A  74
GLU A 326
 None
GOL  A 408 ( 4.3A)
GOL  A 407 (-4.1A)
None
 1.38A 3dh0A-6bqcA:
14.8		 3dh0A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 LYS A 164
TYR A 502
MET A 396
GLU A 473
 None
 1.33A 3dh0A-6f5dA:
2.6		 3dh0A-6f5dA:
undetectable