SIMILAR PATTERNS OF AMINO ACIDS FOR 3DEU_A_SALA303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)

(Drosophila
melanogaster) 		PF00035
(dsrm) 		4 ARG A  64
VAL A  60
LYS A  63
GLU A  67
 None
 0.86A 3deuA-1ekzA:
undetectable		 3deuA-1ekzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ARG A  45
VAL A  84
LYS A  86
GLU A  87
 None
 1.20A 3deuA-1qh4A:
1.2		 3deuA-1qh4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 ARG A 813
VAL A 810
LYS A 809
GLU A 803
 None
 1.14A 3deuA-2j7nA:
0.0		 3deuA-2j7nA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Bacillus
subtilis) 		PF00771
(FHIPEP) 		4 ARG A 641
VAL A 644
LYS A 645
GLU A 528
 None
 1.23A 3deuA-3mixA:
0.2		 3deuA-3mixA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq3 OBP3 PROTEIN

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 ARG A 164
VAL A 158
LYS A 155
GLU A 151
 None
 0.81A 3deuA-3zq3A:
undetectable		 3deuA-3zq3A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 201
VAL A 147
LYS A 145
GLU A 132
 None
 1.26A 3deuA-4a7pA:
0.0		 3deuA-4a7pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 217
VAL A 242
LYS A 218
GLU A 219
 None
 1.32A 3deuA-4nfyA:
0.0		 3deuA-4nfyA:
17.92