SIMILAR PATTERNS OF AMINO ACIDS FOR 3DDY_A_RBFA187_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amx COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05737
(Collagen_bind) 		5 SER A 276
ILE A 207
ASP A 209
ASN A 223
ILE A 224
 None
 1.23A 3ddyA-1amxA:
0.3		 3ddyA-1amxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 390
ILE A 401
ASP A 402
ALA A 400
ILE A 338
 None
 1.23A 3ddyA-1b3bA:
undetectable		 3ddyA-1b3bA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		5 ILE A 635
ASP A 634
ALA A 546
ASN A 562
ILE A 558
 None
HG  A 998 (-3.3A)
None
None
None
 1.23A 3ddyA-1b3qA:
undetectable		 3ddyA-1b3qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 408
SER A 400
ASN A 399
ILE A 304
THR A 338
 None
 1.21A 3ddyA-1e5mA:
undetectable		 3ddyA-1e5mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 VAL A1094
THR A1087
ASP A1414
ASN A1024
ILE A1083
 None
 1.10A 3ddyA-1e6yA:
undetectable		 3ddyA-1e6yA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 VAL A 364
GLN A 408
ALA A 409
THR A 412
ILE A 375
 None
 1.17A 3ddyA-1f59A:
undetectable		 3ddyA-1f59A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 VAL A  85
SER A 267
ILE A 198
ALA A 194
THR A 305
 None
 1.24A 3ddyA-1k25A:
0.0		 3ddyA-1k25A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 SER A 291
ILE A 273
ASP A 225
ALA A 276
ILE A 289
 None
 1.00A 3ddyA-1k8gA:
0.0		 3ddyA-1k8gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 THR A  62
ILE A 273
ASP A 225
ALA A 276
ILE A 289
 None
 1.15A 3ddyA-1k8gA:
0.0		 3ddyA-1k8gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 VAL A  29
SER A  31
ILE A   7
THR A  13
ILE A  33
 None
 1.12A 3ddyA-1nbwA:
0.0		 3ddyA-1nbwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 THR A  62
ILE A 273
ASP A 225
ALA A 276
ILE A 289
 None
 1.11A 3ddyA-1ph5A:
2.6		 3ddyA-1ph5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL B 417
THR B 416
ILE B 437
ALA B 155
ILE B 153
 None
 1.05A 3ddyA-1skyB:
5.5		 3ddyA-1skyB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II

(Sus scrofa) 		PF00431
(CUB) 		5 SER B  21
ILE B  90
GLN B  26
ASN B   4
ILE B   3
 None
 1.25A 3ddyA-1sppB:
undetectable		 3ddyA-1sppB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B  24
THR B  23
ILE B  20
THR B  68
ILE B  69
 None
 1.19A 3ddyA-1t4kB:
undetectable		 3ddyA-1t4kB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 THR A 178
ILE A 141
ALA A 160
THR A 138
ILE A 162
 None
 0.96A 3ddyA-1uzgA:
2.4		 3ddyA-1uzgA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN

(Bacillus
subtilis) 		PF01812
(5-FTHF_cyc-lig) 		5 VAL A 173
SER A 153
THR A 151
THR A  56
ILE A  54
 None
 1.19A 3ddyA-1ydmA:
undetectable		 3ddyA-1ydmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		5 VAL A 152
SER A 154
THR A 122
ILE A 108
ALA A 117
 None
 1.11A 3ddyA-1yt5A:
undetectable		 3ddyA-1yt5A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		5 SER A 264
ILE A  41
GLN A  47
ALA A  44
ASN A 273
 NAP  A 755 (-3.8A)
None
None
None
NAP  A 755 (-3.3A)
 1.19A 3ddyA-1zgdA:
undetectable		 3ddyA-1zgdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		5 THR A  98
ILE A  54
ALA A  23
THR A  36
ILE A  37
 UNX  A 153 ( 4.0A)
None
None
None
None
 1.25A 3ddyA-2ayvA:
undetectable		 3ddyA-2ayvA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 VAL A 110
ASN A 150
ASP A  39
ALA A  42
ILE A 157
 None
 1.14A 3ddyA-2cjeA:
undetectable		 3ddyA-2cjeA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		5 CYH A 151
SER A 152
ALA A 126
THR A  72
ILE A 121
 None
 1.14A 3ddyA-2ehjA:
undetectable		 3ddyA-2ehjA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanopyrus
kandleri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ILE A 171
GLN A 270
ALA A 267
ASN A   4
ILE A   3
 None
 1.19A 3ddyA-2fhkA:
undetectable		 3ddyA-2fhkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492

(Agrobacterium
fabrum) 		PF02627
(CMD) 		5 VAL A 138
ASN A 134
ILE A 130
ALA A  42
ILE A  44
 None
 1.19A 3ddyA-2gmyA:
undetectable		 3ddyA-2gmyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ILE A 477
ASP A 476
ALA A 480
THR A 483
ILE A 484
 None
 1.18A 3ddyA-2j5cA:
undetectable		 3ddyA-2j5cA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 THR A 160
ILE A 164
ASP A 165
GLN A 166
THR A 168
 None
 1.14A 3ddyA-2jirA:
2.8		 3ddyA-2jirA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ko1 GTP
PYROPHOSPHOKINASE

(Chlorobaculum
tepidum) 		PF13291
(ACT_4) 		5 CYH A  47
THR A  35
ILE A  26
THR A  19
ASN A  39
 None
 1.21A 3ddyA-2ko1A:
undetectable		 3ddyA-2ko1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvi POLCALCIN PHL P 7

(Phleum pratense) 		PF13499
(EF-hand_7) 		5 VAL A  39
CYH A  63
THR A  25
ILE A   7
ILE A  60
 None
 1.10A 3ddyA-2lviA:
undetectable		 3ddyA-2lviA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP3)

(Cardiovirus A) 		PF00073
(Rhv) 		5 VAL 3  58
ASN 3  56
ILE 3  65
ALA 3  78
THR 3 188
 None
 1.10A 3ddyA-2mev3:
undetectable		 3ddyA-2mev3:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A 210
SER A 349
ILE A  18
ALA A 365
ILE A 338
 None
 1.00A 3ddyA-2r4jA:
undetectable		 3ddyA-2r4jA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		5 VAL A 201
ILE A 153
ALA A 120
THR A 158
ILE A 118
 None
 0.99A 3ddyA-2rckA:
undetectable		 3ddyA-2rckA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 THR A 173
ILE A 180
ASP A 181
GLN A 178
ALA A 179
 None
 1.11A 3ddyA-2uvfA:
undetectable		 3ddyA-2uvfA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus 1) 		PF13365
(Trypsin_2) 		5 VAL A 457
GLN A 567
ALA A 576
THR A 539
ILE A 578
 None
 1.15A 3ddyA-2w5eA:
3.1		 3ddyA-2w5eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 ILE B 225
ASP B 136
ALA B 135
THR B  16
ILE B  14
 None
 1.18A 3ddyA-2xdqB:
undetectable		 3ddyA-2xdqB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 VAL A 225
SER A 310
THR A 312
ASP A 279
ILE A 259
 None
 1.07A 3ddyA-2xtlA:
undetectable		 3ddyA-2xtlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 THR A 130
ILE A 167
THR A 188
ASN A 138
ILE A 139
 None
 1.15A 3ddyA-2y6iA:
undetectable		 3ddyA-2y6iA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N

(Thermus
thermophilus) 		PF00578
(AhpC-TSA) 		5 THR A 174
GLN A 106
ALA A 109
ASN A  72
ILE A  71
 None
 1.14A 3ddyA-2ywoA:
undetectable		 3ddyA-2ywoA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		7 CYH A  47
ILE A  63
ASP A  64
GLN A  65
ALA A  66
ASN A 101
ILE A 102
 DLZ  A 191 (-3.6A)
DLZ  A 191 (-4.7A)
DLZ  A 191 (-3.9A)
DLZ  A 191 (-3.5A)
DLZ  A 191 (-3.4A)
DLZ  A 191 (-4.5A)
DLZ  A 191 (-4.1A)
 0.92A 3ddyA-3a3gA:
29.2		 3ddyA-3a3gA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		10 VAL A  41
CYH A  47
SER A  48
THR A  50
ILE A  63
ASP A  64
GLN A  65
ALA A  66
THR A  69
ILE A 102
 DLZ  A 191 (-4.4A)
DLZ  A 191 (-3.6A)
DLZ  A 191 (-3.5A)
DLZ  A 191 (-4.1A)
DLZ  A 191 (-4.7A)
DLZ  A 191 (-3.9A)
DLZ  A 191 (-3.5A)
DLZ  A 191 (-3.4A)
DLZ  A 191 (-3.4A)
DLZ  A 191 (-4.1A)
 0.55A 3ddyA-3a3gA:
29.2		 3ddyA-3a3gA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		5 VAL A 305
SER A 282
ASN A 283
THR A 284
THR A 237
 None
None
HEM  A 398 (-3.6A)
None
HEM  A 398 (-3.7A)
 1.13A 3ddyA-3bujA:
undetectable		 3ddyA-3bujA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		5 VAL A 181
ILE A 198
ALA A 191
THR A 189
ILE A 193
 None
 1.25A 3ddyA-3d31A:
2.6		 3ddyA-3d31A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 SER A 548
GLN A 542
ALA A 795
THR A 798
ILE A 799
 None
 1.11A 3ddyA-3dy5A:
undetectable		 3ddyA-3dy5A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 ILE A 304
ASP A 303
ALA A 301
THR A 326
ILE A 327
 None
 1.19A 3ddyA-3f0hA:
undetectable		 3ddyA-3f0hA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 VAL A 226
CYH A 223
THR A 279
ASP A 158
GLN A 391
 None
GSH  A 445 (-2.5A)
None
None
MG  A 446 ( 2.7A)
 1.13A 3ddyA-3g5sA:
undetectable		 3ddyA-3g5sA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 VAL A 577
CYH A 643
ILE A 745
ASP A 635
ILE A 619
 None
 1.08A 3ddyA-3ibjA:
undetectable		 3ddyA-3ibjA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf9 4E10_D0_1IS1A_001_C
(T161)

(synthetic
construct) 		PF01765
(RRF) 		5 ILE A   2
ASP A  80
GLN A  83
ALA A  84
ILE A  88
 None
 1.23A 3ddyA-3lf9A:
undetectable		 3ddyA-3lf9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcc SORTASE SRTA

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 THR A 155
ILE A  76
ASP A  78
ALA A 137
ILE A 193
 None
 1.24A 3ddyA-3rccA:
undetectable		 3ddyA-3rccA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ASN A 154
ILE A 224
ALA A 173
ASN A  78
ILE A 129
 None
 1.12A 3ddyA-3un1A:
undetectable		 3ddyA-3un1A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 VAL A 416
THR A 421
ILE A 387
ALA A 391
ILE A 399
 None
 1.00A 3ddyA-3vm7A:
undetectable		 3ddyA-3vm7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 VAL A 541
ASP A 683
ALA A 713
THR A 662
ASN A 659
 None
 1.17A 3ddyA-3wfaA:
undetectable		 3ddyA-3wfaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkm FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C  24
THR C  23
ILE C  20
THR C  68
ILE C  69
 None
 1.20A 3ddyA-3zkmC:
undetectable		 3ddyA-3zkmC:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 667
ASN A 909
ILE A 700
ASP A 705
ILE A 696
 None
 1.21A 3ddyA-3zyvA:
undetectable		 3ddyA-3zyvA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2z OXYSTEROL-BINDING
PROTEIN HOMOLOG 6

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		5 THR A 218
ILE A 251
ASP A 250
GLN A 248
ALA A 249
 None
 1.25A 3ddyA-4b2zA:
undetectable		 3ddyA-4b2zA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		5 ILE A 406
ASP A 407
ALA A 403
THR A 400
ILE A 399
 None
 1.19A 3ddyA-4c3sA:
undetectable		 3ddyA-4c3sA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		5 SER A 151
ILE A 262
ASP A 263
ALA A 255
ILE A 223
 None
 1.03A 3ddyA-4gk8A:
undetectable		 3ddyA-4gk8A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		5 VAL A 394
ILE A 409
ASP A 410
ALA A 412
ILE A 354
 None
 1.14A 3ddyA-4gx0A:
undetectable		 3ddyA-4gx0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ife GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF04466
(Terminase_3)
PF17288
(Terminase_3C) 		5 VAL A 208
ASP A 212
GLN A 414
ALA A 214
ILE A 216
 None
 1.07A 3ddyA-4ifeA:
undetectable		 3ddyA-4ifeA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 VAL A 191
SER A 189
ILE A 257
ALA A 287
ILE A 304
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.20A 3ddyA-4il5A:
undetectable		 3ddyA-4il5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		5 CYH A 249
SER A 250
ALA A 148
ASN A 202
ILE A 203
 None
 1.09A 3ddyA-4ipaA:
undetectable		 3ddyA-4ipaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpb CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF01584
(CheW) 		5 ILE A 544
ASP A 634
GLN A 632
ALA A 546
ILE A 558
 None
 1.09A 3ddyA-4jpbA:
undetectable		 3ddyA-4jpbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpb CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF01584
(CheW) 		5 ILE A 635
ASP A 634
ALA A 546
ASN A 562
ILE A 558
 None
 1.03A 3ddyA-4jpbA:
undetectable		 3ddyA-4jpbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpb CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF01584
(CheW) 		5 ILE A 635
ASP A 634
GLN A 545
ALA A 546
ILE A 558
 None
 1.16A 3ddyA-4jpbA:
undetectable		 3ddyA-4jpbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5h VVTL1

(Vitis vinifera) 		PF00314
(Thaumatin) 		5 SER A 134
THR A 219
ILE A  68
ALA A 106
ILE A 119
 None
 1.05A 3ddyA-4l5hA:
undetectable		 3ddyA-4l5hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 THR A 373
GLN A 250
ALA A 247
ASN A 381
ILE A 382
 None
 1.18A 3ddyA-4ldsA:
undetectable		 3ddyA-4ldsA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 SER A 203
THR A 205
ILE A  47
ALA A  46
ILE A 189
 None
 1.06A 3ddyA-4m0dA:
undetectable		 3ddyA-4m0dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmq FUSION GLYCOPROTEIN
F1 FUSED WITH
FIBRITIN
TRIMERIZATION DOMAIN

(Escherichia
virus T4;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		5 SER B 493
ASN B 496
ILE B 499
THR B 397
ILE B 395
 None
 1.24A 3ddyA-4mmqB:
undetectable		 3ddyA-4mmqB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4moz FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Slackia
heliotrinireducens) 		PF01791
(DeoC) 		5 VAL A 246
ASP A 257
GLN A 258
THR A 292
ILE A 288
 None
 1.20A 3ddyA-4mozA:
undetectable		 3ddyA-4mozA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		5 ASN A 110
ASP A 164
ALA A 291
THR A 293
ASN A 303
 None
 1.18A 3ddyA-4n9xA:
undetectable		 3ddyA-4n9xA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		no annotation 5 SER B  59
ILE B  62
ASP B  63
ASN B  56
ILE B  57
 None
 1.25A 3ddyA-4nooB:
undetectable		 3ddyA-4nooB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q68 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF07313
(DUF1460) 		5 VAL A  61
THR A  65
ILE A  96
ALA A  72
THR A  76
 None
NAG  A 301 ( 4.8A)
None
None
None
 1.25A 3ddyA-4q68A:
0.7		 3ddyA-4q68A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3

(Homo sapiens) 		PF00179
(UQ_con)
PF13923
(zf-C3HC4_2) 		5 THR L 298
ILE L 254
ALA L 223
THR L 236
ILE L 237
 None
 1.23A 3ddyA-4r8pL:
undetectable		 3ddyA-4r8pL:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		5 THR A 330
ILE A 288
ASP A 287
ALA A 286
ILE A 284
 None
 1.15A 3ddyA-4xupA:
undetectable		 3ddyA-4xupA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xut ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		5 THR A 330
ILE A 288
ASP A 287
ALA A 286
ILE A 284
 None
 1.08A 3ddyA-4xutA:
undetectable		 3ddyA-4xutA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 SER A 380
THR A 408
ILE A 386
ASN A 356
ILE A 355
 None
 1.22A 3ddyA-4z61A:
undetectable		 3ddyA-4z61A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 VAL A 489
SER A 291
ILE A 425
THR A 347
ASN A 340
 None
 1.13A 3ddyA-5d3oA:
undetectable		 3ddyA-5d3oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 5 VAL A 331
CYH A 211
ILE A 308
GLN A 310
ALA A 311
 ADP  A 403 ( 4.8A)
None
None
None
None
 1.02A 3ddyA-5ec0A:
undetectable		 3ddyA-5ec0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		5 VAL B  92
ILE B 189
ALA B 198
THR B 201
ASN B 149
 None
 1.23A 3ddyA-5ej1B:
undetectable		 3ddyA-5ej1B:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erd DESMOGLEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 343
SER A 345
THR A 435
ILE A 398
ASN A 439
 MAN  A 615 ( 3.6A)
None
MAN  A 615 (-2.2A)
None
None
 1.17A 3ddyA-5erdA:
undetectable		 3ddyA-5erdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 VAL C 450
ILE C 134
ASP C 135
ASN C 491
ILE C 492
 None
 1.12A 3ddyA-5fseC:
undetectable		 3ddyA-5fseC:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 ASN B 512
THR B 511
ILE B 485
ASP B 484
ILE B 494
 None
 1.22A 3ddyA-5hz1B:
undetectable		 3ddyA-5hz1B:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 341
SER A 343
THR A 433
ILE A 396
ASN A 437
 MAN  A 611 ( 4.4A)
None
MAN  A 611 (-2.1A)
None
None
 1.15A 3ddyA-5j5jA:
undetectable		 3ddyA-5j5jA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdp VOLTAGE-DEPENDENT
ANION-SELECTIVE
CHANNEL PROTEIN 1

(Homo sapiens) 		PF01459
(Porin_3) 		5 SER A 101
ILE A 114
ASP A 128
THR A  86
ILE A  85
 None
 1.20A 3ddyA-5jdpA:
undetectable		 3ddyA-5jdpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg4 PROTEIN SSO2

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin) 		5 ILE A  88
GLN A  90
ALA A  91
ASN A  56
ILE A  58
 None
 1.18A 3ddyA-5lg4A:
undetectable		 3ddyA-5lg4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A  89
SER A  91
THR A 146
ILE A 149
ALA A 181
 None
 1.18A 3ddyA-5mp2A:
undetectable		 3ddyA-5mp2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 105
SER A 107
THR A 318
ILE A 299
ILE A 295
 None
 1.15A 3ddyA-5mqpA:
undetectable		 3ddyA-5mqpA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19

(Kluyveromyces
lactis) 		no annotation 5 VAL E 186
ILE E 169
ALA E 172
THR E 175
ASN E 179
 None
 1.16A 3ddyA-5mu3E:
undetectable		 3ddyA-5mu3E:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 THR A 341
ILE A 321
ASP A 322
ALA A 317
ILE A 392
 None
 1.08A 3ddyA-5muxA:
undetectable		 3ddyA-5muxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 VAL A 276
ASN A 278
ILE A 280
GLN A 165
ALA A 159
 None
 1.19A 3ddyA-5n1tA:
undetectable		 3ddyA-5n1tA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfr MALATE DEHYDROGENASE

(Plasmodium
falciparum) 		no annotation 5 CYH A 140
THR A 252
ILE A 274
ALA A 279
ILE A 139
 None
 1.16A 3ddyA-5nfrA:
undetectable		 3ddyA-5nfrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		5 ILE A 154
ASP A 155
GLN A 156
ALA A 196
ILE A 247
 None
NAP  A 301 ( 3.8A)
None
None
None
 1.25A 3ddyA-5tgdA:
undetectable		 3ddyA-5tgdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		5 CYH 1 178
ILE 1 128
ALA 1 185
THR 1 125
ILE 1 183
 None
 1.20A 3ddyA-5un01:
undetectable		 3ddyA-5un01:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		no annotation 5 VAL F 424
THR F 419
ILE F 410
ALA F 415
ASN F 395
 None
 1.22A 3ddyA-5wb0F:
undetectable		 3ddyA-5wb0F:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfh SALT STRESS-INDUCED
PROTEIN

(Oryza sativa) 		no annotation 5 SER A  79
THR A  81
ILE A  37
ALA A 107
ILE A  97
 None
 1.15A 3ddyA-5xfhA:
undetectable		 3ddyA-5xfhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 SER A  88
THR A 112
ILE A 114
ASN A  65
ILE A  66
 None
None
None
CL  A 411 ( 4.5A)
None
 1.21A 3ddyA-5xnpA:
undetectable		 3ddyA-5xnpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bg8 IG DOMAIN PROTEIN,
GROUP 2 DOMAIN
PROTEIN

(Shewanella
frigidimarina) 		no annotation 5 THR A 217
ILE A 182
GLN A 178
ALA A 177
ILE A 174
 None
None
None
GOL  A 303 (-4.2A)
None
 1.20A 3ddyA-6bg8A:
undetectable		 3ddyA-6bg8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 5 THR M 483
ILE M 498
ASP M 303
GLN M 300
ALA M 299
 None
 1.19A 3ddyA-6cetM:
undetectable		 3ddyA-6cetM:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg6 CADHERIN-10

(Mus musculus) 		no annotation 5 THR A 198
ILE A 148
GLN A 150
ASN A 202
ILE A 203
 None
 1.11A 3ddyA-6cg6A:
undetectable		 3ddyA-6cg6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgu CADHERIN-6

(Mus musculus) 		no annotation 5 THR A 198
ILE A 148
GLN A 150
ASN A 202
ILE A 203
 THR  A 198 ( 0.8A)
ILE  A 148 ( 0.6A)
GLN  A 150 ( 0.6A)
ASN  A 202 ( 0.6A)
ILE  A 203 ( 0.7A)
 1.10A 3ddyA-6cguA:
undetectable		 3ddyA-6cguA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek7 YAXA

(Yersinia
enterocolitica) 		no annotation 5 SER A 126
ASN A 129
ILE A 132
ASN A 123
ILE A 124
 None
None
None
MPD  A 506 (-3.0A)
MPD  A 506 ( 4.9A)
 1.12A 3ddyA-6ek7A:
undetectable		 3ddyA-6ek7A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 VAL X  27
THR X  26
ILE X 319
ALA X 318
ASN X 311
 None
 0.98A 3ddyA-6elqX:
undetectable		 3ddyA-6elqX:
16.30