SIMILAR PATTERNS OF AMINO ACIDS FOR 3D4S_A_TIMA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahs AFRICAN HORSE
SICKNESS VIRUS
(SEROTYPE 4) VP7

(African horse
sickness virus) 		PF00897
(Orbi_VP7) 		5 VAL A 170
VAL A 231
TRP A 225
PHE A 186
TYR A 129
 None
 1.19A 3d4sA-1ahsA:
undetectable		 3d4sA-1ahsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		5 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.17A 3d4sA-1gy9A:
undetectable		 3d4sA-1gy9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 VAL L 359
SER L 368
TRP L 182
PHE L 175
TYR L 185
 None
 1.46A 3d4sA-1hfeL:
undetectable		 3d4sA-1hfeL:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		5 THR A 177
ASP A 178
ASN A 275
ASN A 277
TYR A 247
 None
None
NAI  A 920 (-3.1A)
None
None
 1.24A 3d4sA-1o0sA:
undetectable		 3d4sA-1o0sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP3)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 THR 3 112
VAL 3 200
VAL 3 201
PHE 3  57
TYR 3 121
 None
 1.30A 3d4sA-1qgc3:
undetectable		 3d4sA-1qgc3:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A  93
VAL A  96
TRP A 155
ASN A  73
TYR A  82
 None
 0.83A 3d4sA-1vf1A:
undetectable		 3d4sA-1vf1A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 TRP A  79
VAL A  73
PHE A 146
TYR A 151
TYR A  80
 None
 1.30A 3d4sA-2bu2A:
2.1		 3d4sA-2bu2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf7 CYTOCHROME C-552

(Escherichia
coli) 		PF02335
(Cytochrom_C552) 		5 TRP A 270
THR A 281
VAL A 208
PHE A 196
TYR A 267
 HEC  A   4 (-4.1A)
None
None
None
None
 1.47A 3d4sA-2rf7A:
undetectable		 3d4sA-2rf7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 THR A1254
VAL A1162
VAL A1251
PHE A1221
TYR A1317
 A3P  A 673 ( 4.8A)
None
None
None
None
 1.43A 3d4sA-3f5fA:
undetectable		 3d4sA-3f5fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feu PUTATIVE LIPOPROTEIN

(Aliivibrio
fischeri) 		PF13462
(Thioredoxin_4) 		5 THR A  24
VAL A  26
VAL A 150
SER A 145
TYR A  71
 None
 1.33A 3d4sA-3feuA:
undetectable		 3d4sA-3feuA:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
TRP A 342
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
None
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.71A 3d4sA-3pblA:
28.1		 3d4sA-3pblA:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
TRP A 342
TYR A 365
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
None
None
ETQ  A1200 (-4.4A)
 1.03A 3d4sA-3pblA:
28.1		 3d4sA-3pblA:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
ASP A 113
VAL A 117
SER A 204
TYR A 316
 None
ERC  A1201 (-3.7A)
None
ERC  A1201 ( 4.1A)
None
 1.30A 3d4sA-3pdsA:
47.2		 3d4sA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
TYR A 308
ASN A 312
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
None
ERC  A1201 (-3.0A)
None
 1.20A 3d4sA-3pdsA:
47.2		 3d4sA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 203
TRP A 286
PHE A 290
ASN A 293
TYR A 308
ASN A 312
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.8A)
None
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-3.0A)
None
 0.68A 3d4sA-3pdsA:
47.2		 3d4sA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 114
ASN A 293
TYR A 308
ASN A 312
TYR A 316
 ERC  A1201 (-3.8A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-3.0A)
None
 1.41A 3d4sA-3pdsA:
47.2		 3d4sA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 103
ASP A 107
TRP A 428
PHE A 432
TYR A 458
 None
5EH  A1200 ( 2.6A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.59A 3d4sA-3rzeA:
35.3		 3d4sA-3rzeA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
PHE A 262
ASN A 284
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 1.17A 3d4sA-4gbrA:
41.2		 3d4sA-4gbrA:
57.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		12 TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 203
TRP A 258
PHE A 262
ASN A 265
TYR A 280
ASN A 284
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.3A)
None
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.51A 3d4sA-4gbrA:
41.2		 3d4sA-4gbrA:
57.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 THR C 112
VAL C 201
VAL C 202
PHE C  57
TYR C 121
 None
 1.24A 3d4sA-4gh4C:
undetectable		 3d4sA-4gh4C:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
VAL A 136
TRP A 337
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
None
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.58A 3d4sA-4ib4A:
27.7		 3d4sA-4ib4A:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
SER A1203
TRP A1286
PHE A1290
TYR A1308
ASN A1312
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.9A)
None
P0G  A1401 (-2.9A)
None
 0.76A 3d4sA-4ldeA:
34.2		 3d4sA-4ldeA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
TRP A1286
PHE A1290
ASN A1293
TYR A1308
ASN A1312
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
None
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
None
P0G  A1401 (-2.9A)
None
 0.58A 3d4sA-4ldeA:
34.2		 3d4sA-4ldeA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		5 VAL A 196
SER A  68
ASN A  35
TYR A 147
ASN A 210
 None
None
None
2Q2  A 403 (-4.1A)
2Q2  A 403 (-2.8A)
 1.23A 3d4sA-4o8mA:
undetectable		 3d4sA-4o8mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q20 SENSOR PROTEIN DIVL

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 THR A 672
ASP A 695
VAL A 678
VAL A 693
ASN A 667
 None
 1.42A 3d4sA-4q20A:
undetectable		 3d4sA-4q20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH2

(Mycobacterium
tuberculosis) 		no annotation 5 THR B  56
ASP B  55
VAL B  50
TRP B  84
PHE B  19
 None
 1.36A 3d4sA-4w78B:
undetectable		 3d4sA-4w78B:
14.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 215
PHE B 307
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.9A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.25A 3d4sA-5f8uB:
39.7		 3d4sA-5f8uB:
41.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 11 TRP B 117
THR B 118
ASP B 121
VAL B 122
VAL B 125
SER B 211
TRP B 303
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-2.7A)
None
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.56A 3d4sA-5f8uB:
39.7		 3d4sA-5f8uB:
41.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		5 VAL A 633
VAL A 637
PHE A 242
ASN A 596
TYR A 251
 None
 1.49A 3d4sA-5gamA:
undetectable		 3d4sA-5gamA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 TRP A  64
THR A  66
ASP A 124
VAL A 126
SER A  71
 None
 1.32A 3d4sA-5h05A:
undetectable		 3d4sA-5h05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1q INNEXIN-6

(Caenorhabditis
elegans) 		PF00876
(Innexin) 		5 THR A 268
VAL A 266
VAL A 246
ASN A  73
TYR A 105
 None
 1.45A 3d4sA-5h1qA:
3.9		 3d4sA-5h1qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5net O1 MANISA VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 THR 3 112
VAL 3 200
VAL 3 201
PHE 3  57
TYR 3 121
 None
 1.37A 3d4sA-5net3:
undetectable		 3d4sA-5net3:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
TRP A 327
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-3.6A)
89F  A1201 (-4.6A)
None
 0.78A 3d4sA-5v54A:
28.0		 3d4sA-5v54A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 THR A 388
ASP A 389
VAL A 328
SER A 324
TYR A 341
 HEM  A 800 ( 4.0A)
None
None
HEM  A 800 (-2.9A)
None
 1.32A 3d4sA-5whsA:
undetectable		 3d4sA-5whsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
TRP A 407
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
None
AQD  A1201 (-4.6A)
None
 0.74A 3d4sA-5wivA:
30.4		 3d4sA-5wivA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 THR A 270
VAL A 357
VAL A 352
TYR A 199
ASN A 197
 None
None
None
None
MG  A 728 (-3.6A)
 1.27A 3d4sA-5yjhA:
undetectable		 3d4sA-5yjhA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.32A 3d4sA-6bqhA:
30.8		 3d4sA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
TRP A 324
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
None
 0.57A 3d4sA-6bqhA:
30.8		 3d4sA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
VAL A 135
TRP A 324
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 0.73A 3d4sA-6bqhA:
30.8		 3d4sA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 ASP A 114
VAL A 115
TRP A 386
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.61A 3d4sA-6cm4A:
35.5		 3d4sA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.58A 3d4sA-6g79S:
27.9		 3d4sA-6g79S:
9.93