SIMILAR PATTERNS OF AMINO ACIDS FOR 3D41_A_FCNA4001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 119
GLY A 118
GLY A 132
ILE A 133
 H2S  A 904 (-3.5A)
H2S  A 904 ( 4.4A)
None
None
 0.68A 3d41A-1e3dA:
undetectable		 3d41A-1e3dA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLY B2170
GLY B2169
GLY B2061
THR B2164
 None
 0.69A 3d41A-1e6yB:
undetectable		 3d41A-1e6yB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli) 		PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP) 		4 GLY A 227
GLY A 226
GLY A 207
ILE A 275
 None
 0.69A 3d41A-1glvA:
3.0		 3d41A-1glvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		5 GLY A 366
GLY A 271
GLY A 268
HIS A 270
ILE A 266
 None
 1.18A 3d41A-1kp2A:
3.0		 3d41A-1kp2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A  23
GLY A  24
GLY A  84
THR A  78
 None
 0.70A 3d41A-1mwoA:
undetectable		 3d41A-1mwoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLY C 323
GLY C 351
GLY C 387
ILE C 410
 None
 0.62A 3d41A-1n8yC:
undetectable		 3d41A-1n8yC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 GLY A 114
GLY A 113
GLY A  44
SER A 137
 None
 0.59A 3d41A-1pjaA:
undetectable		 3d41A-1pjaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		4 GLY A  21
GLY A  22
GLY A  42
SER A  19
 None
 0.64A 3d41A-1pvxA:
undetectable		 3d41A-1pvxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		4 GLY A  19
GLY A  18
GLY A  15
THR A  67
 None
 0.60A 3d41A-1qpwA:
undetectable		 3d41A-1qpwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 GLY A 202
GLY A   7
ILE A   8
THR A  71
 None
 0.64A 3d41A-1scjA:
undetectable		 3d41A-1scjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		4 GLY A 244
GLY A 246
GLY A 139
THR A 109
 SO4  A 373 (-3.5A)
None
None
None
 0.69A 3d41A-1to6A:
undetectable		 3d41A-1to6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 GLY A  21
GLY A  22
GLY A  42
SER A  19
 None
 0.61A 3d41A-1ynaA:
undetectable		 3d41A-1ynaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		4 GLY A 120
GLY A 121
ILE A 156
SER A 149
 SO4  A 303 ( 4.1A)
None
None
None
 0.70A 3d41A-1ynqA:
undetectable		 3d41A-1ynqA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 GLY A 253
GLY A 252
ILE A 154
SER A 207
 None
 0.65A 3d41A-1zliA:
2.8		 3d41A-1zliA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 GLY A 136
GLY A 135
GLY A 134
SER A 138
THR A 141
 None
 1.41A 3d41A-2b6nA:
undetectable		 3d41A-2b6nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		4 GLY A 179
GLY A  30
ILE A  35
SER A 200
 None
 0.53A 3d41A-2dvzA:
undetectable		 3d41A-2dvzA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esb DUAL SPECIFICITY
PROTEIN PHOSPHATASE
18

(Homo sapiens) 		PF00782
(DSPc) 		4 GLY A  32
GLY A 107
ILE A 140
SER A  18
 None
EPE  A1002 (-4.3A)
None
None
 0.65A 3d41A-2esbA:
undetectable		 3d41A-2esbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6z LIM DOMAIN ONLY 2,
LINKER, LIM
DOMAIN-BINDING
PROTEIN 1

(Mus musculus) 		PF00412
(LIM) 		4 GLY C 166
GLY C 165
GLY C 159
THR C 152
 None
 0.70A 3d41A-2l6zC:
undetectable		 3d41A-2l6zC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		4 GLY A 334
GLY A 337
HIS A 338
SER A 313
 None
FAD  A1373 ( 3.7A)
None
None
 0.69A 3d41A-2uzzA:
undetectable		 3d41A-2uzzA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 GLY A  87
GLY A  86
GLY A  84
SER A 122
 None
 0.64A 3d41A-2wfiA:
undetectable		 3d41A-2wfiA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		4 GLY A 180
GLY A 185
HIS A 188
ILE A 187
 None
 0.69A 3d41A-2x47A:
undetectable		 3d41A-2x47A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 4 GLY A  30
GLY A  68
ILE A  63
THR A  16
 None
 0.67A 3d41A-2x5qA:
undetectable		 3d41A-2x5qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xjy LIM DOMAIN-BINDING
PROTEIN 1
RHOMBOTIN-2

(Homo sapiens) 		PF00412
(LIM)
no annotation 		4 GLY B 348
GLY B 347
ILE A 101
THR A 107
 None
 0.49A 3d41A-2xjyB:
undetectable		 3d41A-2xjyB:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 GLY A 285
GLY A 286
GLY A   9
SER A 283
 None
 0.49A 3d41A-2yjgA:
undetectable		 3d41A-2yjgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 GLY A 305
GLY A  89
ILE A  90
THR A 160
 None
 0.64A 3d41A-2z2xA:
2.2		 3d41A-2z2xA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 GLY A 305
GLY A  89
ILE A  90
THR A 160
 None
 0.64A 3d41A-2z2zA:
2.1		 3d41A-2z2zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 GLY A 462
GLY A 463
GLY A 327
ILE A 376
 None
 0.69A 3d41A-2zwsA:
undetectable		 3d41A-2zwsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 544
GLY A 543
GLY A 792
THR A 821
 None
 0.51A 3d41A-2zxqA:
undetectable		 3d41A-2zxqA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		4 GLY A 231
GLY A   9
ILE A  10
THR A  78
 None
 0.68A 3d41A-3d43A:
2.7		 3d41A-3d43A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		4 GLY A 105
GLY A 104
GLY A  11
SER A 132
 None
None
SO4  A 256 ( 3.5A)
None
 0.70A 3d41A-3ds8A:
undetectable		 3d41A-3ds8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 307
SER A 339
SER A 211
THR A 343
 None
 0.63A 3d41A-3e1hA:
undetectable		 3d41A-3e1hA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A 337
GLY A 338
GLY A 339
ILE A 321
 None
 0.67A 3d41A-3hriA:
undetectable		 3d41A-3hriA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLY A   5
GLY A  35
GLY A  60
ILE A  80
 None
 0.70A 3d41A-3i2tA:
undetectable		 3d41A-3i2tA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 GLY A 563
GLY A 564
GLY A  49
ILE A  53
 None
 0.44A 3d41A-3i3lA:
undetectable		 3d41A-3i3lA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 GLY A 477
GLY A 476
ILE A 443
THR A 447
 None
 0.58A 3d41A-3ilvA:
undetectable		 3d41A-3ilvA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Venezuelan
equine
encephalitis
virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		5 GLY A  91
GLY A  90
HIS B  71
SER B 177
SER B 176
 None
 1.05A 3d41A-3j0cA:
undetectable		 3d41A-3j0cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		4 GLY A  39
GLY A  14
HIS A  15
ILE A  80
 None
None
ZN  A 200 (-3.5A)
None
 0.53A 3d41A-3jygA:
undetectable		 3d41A-3jygA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		4 GLY A  54
GLY A  55
GLY A  59
HIS A  60
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-2.8A)
IPE  A 300 (-3.1A)
 0.29A 3d41A-3k4yA:
22.8		 3d41A-3k4yA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		4 GLY A  54
GLY A  55
GLY A  59
ILE A  86
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-2.8A)
None
 0.67A 3d41A-3k4yA:
22.8		 3d41A-3k4yA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLY A 699
ILE A 697
SER A 714
SER A 703
THR A 640
 None
 0.92A 3d41A-3l2pA:
undetectable		 3d41A-3l2pA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 313
GLY A 273
GLY A 275
ILE A  67
THR A  69
 None
LLP  A 270 ( 4.0A)
None
None
None
 1.29A 3d41A-3l44A:
undetectable		 3d41A-3l44A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00696
(AA_kinase) 		4 GLY A  44
GLY A  45
GLY A  49
HIS A  50
 IPE  A 247 (-3.3A)
IPE  A 247 (-3.8A)
IPE  A 247 (-3.3A)
IPE  A 247 (-4.1A)
 0.39A 3d41A-3ll5A:
23.2		 3d41A-3ll5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		4 GLY A 108
GLY A 107
GLY A  11
SER A 135
 None
 0.60A 3d41A-3lp5A:
undetectable		 3d41A-3lp5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 GLY A 306
GLY A 305
GLY A 143
HIS A 145
ILE A 161
 LLX  A 400 (-3.7A)
LLX  A 400 (-3.5A)
None
LLX  A 400 (-4.0A)
None
 1.27A 3d41A-3maxA:
undetectable		 3d41A-3maxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlp TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF01833
(TIG)
PF16422
(COE1_DBD)
PF16423
(COE1_HLH) 		4 GLY A  91
ILE A 108
SER A 178
THR A 156
 CIT  A   3 (-3.4A)
None
None
None
 0.70A 3d41A-3mlpA:
undetectable		 3d41A-3mlpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLY A 315
GLY A 343
GLY A 379
ILE A 402
 None
 0.61A 3d41A-3njpA:
undetectable		 3d41A-3njpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 GLY A 116
GLY A 115
GLY A  41
SER A 138
 None
None
EDO  A 312 ( 4.5A)
None
 0.52A 3d41A-3nwoA:
undetectable		 3d41A-3nwoA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME

(Vibrio cholerae) 		PF01965
(DJ-1_PfpI) 		4 GLY B  52
GLY B  49
GLY B  16
HIS B  15
 None
 0.70A 3d41A-3ot1B:
undetectable		 3d41A-3ot1B:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 234
GLY A 235
GLY A 236
ILE A  11
SER A  14
 None
 0.95A 3d41A-3oytA:
undetectable		 3d41A-3oytA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		4 GLY A 321
GLY A 198
GLY A 222
SER A 335
 None
None
FMT  A 403 ( 4.3A)
None
 0.70A 3d41A-3q3vA:
3.9		 3d41A-3q3vA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		4 GLY A 165
GLY A 164
GLY A 291
SER A  12
 ADP  A 601 (-3.9A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
 0.68A 3d41A-3qbwA:
undetectable		 3d41A-3qbwA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A  23
GLY A  24
GLY A  84
THR A  78
 None
CA  A 502 (-4.2A)
CA  A 502 ( 4.4A)
None
 0.63A 3d41A-3qgvA:
undetectable		 3d41A-3qgvA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qvf FOMA PROTEIN

(Streptomyces
wedmorensis) 		PF00696
(AA_kinase) 		8 GLY A  52
GLY A  53
GLY A  57
HIS A  58
ILE A  61
SER A 148
SER A 149
THR A 210
 FV1  A4001 (-3.5A)
FV1  A4001 (-3.2A)
FV1  A4001 (-3.4A)
FV1  A4001 (-4.0A)
None
FV1  A4001 (-2.6A)
FV1  A4001 (-2.6A)
FV1  A4001 (-2.8A)
 0.16A 3d41A-3qvfA:
47.5		 3d41A-3qvfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qvf FOMA PROTEIN

(Streptomyces
wedmorensis) 		PF00696
(AA_kinase) 		5 GLY A  54
GLY A  57
HIS A  58
ILE A  61
THR A 210
 FV1  A4001 (-3.2A)
FV1  A4001 (-3.4A)
FV1  A4001 (-4.0A)
None
FV1  A4001 (-2.8A)
 0.96A 3d41A-3qvfA:
47.5		 3d41A-3qvfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLY A 311
GLY A 339
GLY A 375
ILE A 398
 None
 0.65A 3d41A-3u7uA:
undetectable		 3d41A-3u7uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 GLY A 292
GLY A  97
ILE A  98
THR A 161
 None
 0.64A 3d41A-3whiA:
undetectable		 3d41A-3whiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x29 CLAUDIN-19

(Mus musculus) 		PF00822
(PMP22_Claudin) 		5 GLY A 178
GLY A 179
GLY A 123
ILE A 120
THR A 185
 None
 1.08A 3d41A-3x29A:
undetectable		 3d41A-3x29A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		4 GLY A 115
GLY A  10
ILE A  48
SER A 119
 GDP  A 999 (-3.7A)
GDP  A 999 (-3.5A)
None
None
 0.68A 3d41A-3zidA:
2.6		 3d41A-3zidA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 GLY A 257
GLY A 295
GLY A 132
HIS A 134
ILE A 150
 None
None
None
ACT  A 501 (-4.0A)
None
 1.01A 3d41A-4a69A:
2.3		 3d41A-4a69A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 GLY A 296
GLY A 295
GLY A 132
HIS A 134
ILE A 150
 ACT  A 501 (-3.0A)
None
None
ACT  A 501 (-4.0A)
None
 1.21A 3d41A-4a69A:
2.3		 3d41A-4a69A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 GLY D 201
GLY D 200
ILE D 163
THR D 130
 None
 0.65A 3d41A-4ayiD:
undetectable		 3d41A-4ayiD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 GLY B 301
GLY B 300
GLY B 138
HIS B 140
ILE B 156
 ACT  B 601 (-3.4A)
ACT  B 601 ( 4.8A)
None
ACT  B 601 (-3.7A)
None
 1.26A 3d41A-4bkxB:
undetectable		 3d41A-4bkxB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		5 GLY A 339
GLY A 338
GLY A 139
HIS A 141
ILE A 157
 B3N  A 700 ( 4.1A)
None
None
B3N  A 700 (-3.9A)
None
 1.20A 3d41A-4bz7A:
2.2		 3d41A-4bz7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 117
GLY A 118
GLY A 355
SER A  98
 None
 0.55A 3d41A-4c2kA:
undetectable		 3d41A-4c2kA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 117
GLY A 118
GLY A 356
SER A  98
 None
 0.70A 3d41A-4c2kA:
undetectable		 3d41A-4c2kA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 332
GLY A 426
GLY A 425
ILE A 421
SER A 373
 None
 1.36A 3d41A-4c7vA:
undetectable		 3d41A-4c7vA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 118
GLY A 119
GLY A 356
SER A  99
 None
 0.70A 3d41A-4dd5A:
undetectable		 3d41A-4dd5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		4 GLY A 100
GLY A  99
GLY A  30
SER A 123
 None
None
EDO  A 301 ( 4.0A)
None
 0.66A 3d41A-4dgqA:
undetectable		 3d41A-4dgqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		4 GLY A 238
GLY A 237
GLY A 226
ILE A 228
 BOG  A 405 (-3.6A)
None
None
None
 0.68A 3d41A-4ezdA:
undetectable		 3d41A-4ezdA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 GLY A 538
GLY A 516
HIS A 515
SER A 412
 None
None
None
0WB  A 701 ( 4.9A)
 0.69A 3d41A-4g3fA:
undetectable		 3d41A-4g3fA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		5 GLY A 125
GLY A 102
GLY A 105
HIS A 106
ILE A 109
 None
 1.03A 3d41A-4g8dA:
undetectable		 3d41A-4g8dA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 GLY A 214
GLY A 213
GLY A 352
SER A  23
 ATP  A 502 (-3.6A)
ATP  A 502 (-3.4A)
ATP  A 502 (-3.4A)
ATP  A 502 (-2.6A)
 0.68A 3d41A-4gniA:
undetectable		 3d41A-4gniA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		5 GLY A 413
GLY A 414
ILE A 380
SER A 350
SER A 411
 None
 1.14A 3d41A-4gwnA:
undetectable		 3d41A-4gwnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 GLY A  91
GLY A  94
GLY A  97
ILE A 101
 None
 0.46A 3d41A-4humA:
undetectable		 3d41A-4humA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqy O-ACETYL-ADP-RIBOSE
DEACETYLASE MACROD2

(Homo sapiens) 		PF01661
(Macro) 		4 GLY A  98
GLY A 103
HIS A 106
ILE A 105
 AR6  A 301 ( 3.7A)
None
None
None
 0.68A 3d41A-4iqyA:
undetectable		 3d41A-4iqyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 120
GLY A 119
GLY A 114
ILE A 112
 None
 0.65A 3d41A-4jbhA:
2.2		 3d41A-4jbhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku0 UNCHARACTERIZED 10.2
KDA PROTEIN IN
SEGC-GP6 INTERGENIC
REGION

(Escherichia
virus T4) 		PF05488
(PAAR_motif) 		4 GLY D  58
GLY D  57
HIS D  46
THR D  20
 None
None
FE  D 101 (-3.2A)
None
 0.61A 3d41A-4ku0D:
undetectable		 3d41A-4ku0D:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		4 GLY A 228
GLY A 229
GLY A 259
THR A 266
 None
 0.66A 3d41A-4n0qA:
undetectable		 3d41A-4n0qA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 GLY A 382
GLY A 345
HIS A 348
ILE A 347
 None
 0.70A 3d41A-4s28A:
undetectable		 3d41A-4s28A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrp HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
cruzi) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A 338
GLY A 339
GLY A 340
ILE A 322
 None
HIS  A 501 ( 4.3A)
None
None
 0.66A 3d41A-4yrpA:
undetectable		 3d41A-4yrpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 GLY A  44
ILE A 326
SER A 293
THR A 268
 None
 0.67A 3d41A-5bnzA:
2.3		 3d41A-5bnzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLY A 510
GLY A 509
GLY A 429
ILE A 427
SER A 444
 None
 1.46A 3d41A-5dotA:
undetectable		 3d41A-5dotA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 GLY A 146
GLY A 147
GLY A  41
HIS A 149
ILE A  39
 None
 1.21A 3d41A-5du9A:
undetectable		 3d41A-5du9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		4 GLY A 112
GLY A 113
ILE A 174
THR A 178
 NAP  A 301 (-3.7A)
None
None
None
 0.62A 3d41A-5ff9A:
4.2		 3d41A-5ff9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		4 GLY A 232
GLY A  10
ILE A  11
THR A  79
 None
 0.67A 3d41A-5ffnA:
2.5		 3d41A-5ffnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 GLY M  37
GLY M  38
ILE M  41
SER M 168
 None
 0.66A 3d41A-5fmgM:
undetectable		 3d41A-5fmgM:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		4 GLY A  36
GLY A  41
HIS A  44
ILE A  43
 MES  A1188 ( 3.7A)
None
None
None
 0.65A 3d41A-5fudA:
undetectable		 3d41A-5fudA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		5 GLY A 134
GLY A 141
SER A 123
SER A 139
THR A 203
 None
 0.96A 3d41A-5jiaA:
undetectable		 3d41A-5jiaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jiu RAN-BINDING PROTEIN
9

(Homo sapiens) 		PF00622
(SPRY) 		4 GLY A 246
GLY A 253
SER A 235
THR A 315
 None
 0.67A 3d41A-5jiuA:
undetectable		 3d41A-5jiuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 4 GLY C 113
GLY C 114
GLY C 350
SER C  94
 None
 0.65A 3d41A-5mg5C:
undetectable		 3d41A-5mg5C:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 GLY E 146
GLY E 147
GLY E 150
THR E 194
 GTP  E 500 (-3.4A)
GTP  E 500 (-3.1A)
GTP  E 500 (-3.2A)
None
 0.65A 3d41A-5mjsE:
undetectable		 3d41A-5mjsE:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 4 GLY C 322
GLY C 350
GLY C 386
ILE C 409
 None
 0.57A 3d41A-5o4gC:
undetectable		 3d41A-5o4gC:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		4 GLY A 467
GLY A 470
ILE A 474
SER A 490
 None
 0.64A 3d41A-5sv9A:
undetectable		 3d41A-5sv9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 GLY A 624
GLY A 625
GLY A 464
SER A 473
 None
 0.53A 3d41A-5svcA:
undetectable		 3d41A-5svcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 GLY M 315
GLY M 343
GLY M 379
ILE M 402
 None
 0.66A 3d41A-5sx4M:
undetectable		 3d41A-5sx4M:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us8 ARGININOSUCCINATE
SYNTHASE

(Bordetella
pertussis) 		PF00764
(Arginosuc_synth) 		5 GLY A 367
GLY A 272
GLY A 269
HIS A 271
ILE A 267
 None
 1.15A 3d41A-5us8A:
2.3		 3d41A-5us8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		4 GLY A 180
GLY A 181
GLY A 176
ILE A 201
 None
 0.70A 3d41A-5xw3A:
undetectable		 3d41A-5xw3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 4 GLY A 156
GLY A 167
ILE A 169
SER A 159
 None
 0.68A 3d41A-6blgA:
undetectable		 3d41A-6blgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 4 GLY A  74
GLY A  73
GLY A 150
ILE A 147
 None
 0.64A 3d41A-6bvgA:
undetectable		 3d41A-6bvgA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 GLY A 398
GLY A 397
GLY A 264
ILE A 260
 None
 0.65A 3d41A-6es9A:
undetectable		 3d41A-6es9A:
13.45