SIMILAR PATTERNS OF AMINO ACIDS FOR 3CZH_B_D2VB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
 None
 0.84A 3czhB-1cg4A:
0.0		 3czhB-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		5 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
 None
 1.07A 3czhB-1ci9A:
0.0		 3czhB-1ci9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 THR A 580
PHE A 535
ALA A 479
ALA A 570
VAL A 568
 None
None
NA  A 996 (-3.0A)
CL  A 995 ( 4.9A)
None
 1.12A 3czhB-1ck7A:
undetectable		 3czhB-1ck7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ALA A  84
ALA A 114
THR A   8
VAL A  10
ILE A  93
 None
 1.03A 3czhB-1cqjA:
0.0		 3czhB-1cqjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		5 LEU A 143
ALA A  81
THR A  64
VAL A  70
ILE A  51
 None
 1.11A 3czhB-1f5vA:
0.0		 3czhB-1f5vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 PHE A 805
ALA A 549
ALA A 734
VAL A 778
VAL A 826
 None
FMN  A1030 (-3.3A)
None
None
None
 1.14A 3czhB-1h7wA:
0.0		 3czhB-1h7wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A 157
ALA A 178
ALA A 203
THR A 260
ILE A 153
 None
 1.15A 3czhB-1k82A:
0.0		 3czhB-1k82A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 203
ALA A  30
VAL A  63
ILE A 218
THR A 174
 None
 1.04A 3czhB-1m2wA:
0.0		 3czhB-1m2wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C 128
ALA C 278
ALA C 196
VAL C 219
ILE C  93
 None
 1.09A 3czhB-1n61C:
0.0		 3czhB-1n61C:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 THR A 647
LEU A 633
ALA A 651
VAL A 428
VAL A 369
 None
 0.99A 3czhB-1n76A:
undetectable		 3czhB-1n76A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p22 F-BOX/WD-REPEAT
PROTEIN 1A
SKP1

(Homo sapiens) 		PF00400
(WD40)
PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		5 LEU A 148
ALA B 103
ALA A 172
VAL A 175
ILE B  83
 None
 1.00A 3czhB-1p22A:
undetectable		 3czhB-1p22A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A   8
ALA A 152
VAL A 153
MET A 173
THR A 174
 None
 1.14A 3czhB-1qi7A:
undetectable		 3czhB-1qi7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		5 LEU A 125
ALA A 199
VAL A 196
VAL A 141
ILE A 134
 None
 1.12A 3czhB-1rpxA:
undetectable		 3czhB-1rpxA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 THR A 214
ASN A 256
ALA A 145
ALA A 201
ILE A 150
 None
 0.99A 3czhB-1rrmA:
undetectable		 3czhB-1rrmA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtg HUMAN GELATINASE A

(Homo sapiens) 		PF00045
(Hemopexin) 		5 THR A 580
PHE A 535
ALA A 479
ALA A 570
VAL A 568
 None
None
CA  A   2 ( 3.9A)
CL  A   1 ( 4.1A)
None
 1.13A 3czhB-1rtgA:
undetectable		 3czhB-1rtgA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 272
ALA A 300
ALA A   8
VAL A   9
THR A 289
 None
 1.16A 3czhB-1t5cA:
undetectable		 3czhB-1t5cA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 231
ALA A 374
ALA A 176
VAL A 360
ILE A  35
 LEU  A 231 ( 0.6A)
ALA  A 374 ( 0.0A)
ALA  A 176 ( 0.0A)
VAL  A 360 ( 0.6A)
ILE  A  35 ( 0.6A)
 0.82A 3czhB-1tedA:
undetectable		 3czhB-1tedA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU X 430
ALA X 286
VAL X 417
ILE X 426
THR X 416
 None
 1.03A 3czhB-1u8xX:
undetectable		 3czhB-1u8xX:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 THR A 324
ALA A 317
VAL A  53
THR A 186
ILE A 289
 None
 1.09A 3czhB-1un9A:
undetectable		 3czhB-1un9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A  20
PHE A  34
ALA A  72
VAL A 136
ILE A 302
 None
 1.00A 3czhB-1up4A:
undetectable		 3czhB-1up4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		5 LEU A 106
ALA A 177
VAL A 142
ILE A  20
MET A 179
 None
 1.15A 3czhB-1vliA:
undetectable		 3czhB-1vliA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		5 THR A 111
LEU A 182
PHE A 185
VAL A  69
ILE A 255
 SO4  A1391 (-3.4A)
None
None
None
None
 1.10A 3czhB-1vz8A:
undetectable		 3czhB-1vz8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		5 THR A 108
LEU A  92
ALA A  46
VAL A  66
ILE A 159
 None
 1.03A 3czhB-1wz9A:
undetectable		 3czhB-1wz9A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 298
ASN A 434
ALA A 395
VAL A 394
ILE A 297
 None
 1.12A 3czhB-1xfdA:
undetectable		 3czhB-1xfdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 LEU A 389
ASN A 482
ALA A 382
THR A  93
VAL A  52
 None
 1.06A 3czhB-1xjeA:
undetectable		 3czhB-1xjeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		5 ASN A 184
ALA A  19
ALA A  99
VAL A 103
THR A  54
 None
None
MC3  A 270 ( 3.7A)
MC3  A 265 (-4.1A)
None
 1.16A 3czhB-2b6oA:
undetectable		 3czhB-2b6oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh7 NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		5 THR A 170
PHE A 120
ALA A 126
ALA A 151
ILE A 108
 None
 1.01A 3czhB-2dh7A:
undetectable		 3czhB-2dh7A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE

(Variovorax sp.
Pal2) 		PF13714
(PEP_mutase) 		5 LEU A   7
ALA A  80
ALA A  71
VAL A  74
VAL A 209
 None
 1.09A 3czhB-2duaA:
undetectable		 3czhB-2duaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa1 PROBABLE
TRANSCRIPTIONAL
REGULATOR PHNF

(Escherichia
coli) 		PF07702
(UTRA) 		5 THR A 175
LEU A 159
ALA A 223
ALA A 178
ILE A 130
 None
 1.07A 3czhB-2fa1A:
undetectable		 3czhB-2fa1A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04268
(SoxG) 		5 THR C 168
ALA C 153
THR C 182
VAL C 186
THR C 185
 None
 1.05A 3czhB-2gahC:
undetectable		 3czhB-2gahC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea) 		PF00139
(Lectin_legB) 		5 THR A  37
ALA A  63
VAL A  65
THR A  96
ILE A  32
 None
 1.15A 3czhB-2gdfA:
undetectable		 3czhB-2gdfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		5 ALA A 227
ALA A 205
VAL A 141
ILE A 139
THR A 240
 None
 1.15A 3czhB-2gszA:
undetectable		 3czhB-2gszA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 215
PHE A 117
VAL A  90
MET A  72
THR A  76
 None
 1.11A 3czhB-2j2mA:
undetectable		 3czhB-2j2mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  25
ALA A 374
ALA A 311
VAL A 309
ILE A  20
 None
 0.89A 3czhB-2p3eA:
undetectable		 3czhB-2p3eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 254
ALA A 170
ALA A 267
VAL A 293
ILE A 250
 None
 1.09A 3czhB-2v6bA:
undetectable		 3czhB-2v6bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		5 LEU A 283
ALA A 323
VAL A 333
ILE A 537
THR A 555
 None
 1.06A 3czhB-2vpjA:
undetectable		 3czhB-2vpjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ad9 SARCOSINE OXIDASE
GAMMA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04268
(SoxG) 		5 THR C 166
ALA C 151
THR C 180
VAL C 184
THR C 183
 None
 1.08A 3czhB-3ad9C:
undetectable		 3czhB-3ad9C:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 LEU A 371
ASN A 374
ALA A 382
THR A 283
VAL A 287
 None
 0.80A 3czhB-3aqiA:
undetectable		 3czhB-3aqiA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		6 ALA A 222
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 1.36A 3czhB-3c6gA:
62.7		 3czhB-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		12 THR A 119
LEU A 125
ASN A 126
PHE A 214
ALA A 221
ALA A 250
VAL A 253
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
HEM  A 601 (-4.3A)
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 ( 3.8A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.25A 3czhB-3c6gA:
62.7		 3czhB-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 LEU A  57
ALA A 177
ALA A 183
VAL A 241
MET A 239
 None
 1.03A 3czhB-3cdxA:
undetectable		 3czhB-3cdxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 163
ALA A 805
VAL A 651
ILE A 167
THR A 683
 None
 1.13A 3czhB-3ddrA:
undetectable		 3czhB-3ddrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 ASN A 829
PHE A 761
ALA A 682
VAL A 814
ILE A 838
 None
 1.00A 3czhB-3egiA:
undetectable		 3czhB-3egiA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A 323
ALA A 334
ALA A 190
VAL A 187
VAL A 233
 None
 0.97A 3czhB-3hriA:
undetectable		 3czhB-3hriA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 ASN A 284
ALA A 161
ALA A  91
THR A 182
THR A 154
 None
 1.14A 3czhB-3k2wA:
undetectable		 3czhB-3k2wA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN

(Xanthomonas
citri) 		PF09084
(NMT1) 		5 LEU A 146
ALA A 170
ALA A  67
VAL A 117
ILE A 134
 None
None
MPO  A 325 ( 3.7A)
None
None
 1.09A 3czhB-3ksxA:
undetectable		 3czhB-3ksxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		5 ALA A 349
VAL A  36
THR A  93
VAL A 109
MET A 328
 None
 1.04A 3czhB-3lreA:
undetectable		 3czhB-3lreA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 LEU A 167
ALA A 275
ALA A 236
ILE A 198
THR A 120
 None
ELA  A 301 ( 4.2A)
None
None
ELA  A 301 (-4.4A)
 1.09A 3czhB-3lupA:
undetectable		 3czhB-3lupA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A  15
ALA A 120
ALA A 329
VAL A 333
THR A 111
 None
None
None
None
GOL  A 349 (-3.8A)
 1.00A 3czhB-3pi7A:
undetectable		 3czhB-3pi7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 218
ALA A 262
ALA A 271
THR A 149
VAL A  34
 None
 1.06A 3czhB-3pygA:
undetectable		 3czhB-3pygA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A  80
PHE A  44
ALA A 145
VAL A 144
ILE A  78
 None
 0.99A 3czhB-3r92A:
undetectable		 3czhB-3r92A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE

(Actinomadura
kijaniata) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  67
ALA A 100
ALA A 118
VAL A 117
ILE A  15
 None
 1.09A 3czhB-3rc2A:
undetectable		 3czhB-3rc2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siv NHP2-LIKE PROTEIN 1

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		5 ALA A  39
ALA A  57
VAL A  83
THR A 105
THR A  45
 U  F  36 ( 3.1A)
None
None
None
None
 1.06A 3czhB-3sivA:
undetectable		 3czhB-3sivA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		5 PHE A 253
ALA A 194
VAL A  86
THR A 103
VAL A 109
 None
 1.14A 3czhB-3t32A:
undetectable		 3czhB-3t32A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 282
VAL A 269
THR A 174
VAL A 178
THR A 295
 None
 0.98A 3czhB-3tbhA:
undetectable		 3czhB-3tbhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 THR A 148
ALA A 157
THR A 131
VAL A 161
MET A 159
 None
 0.99A 3czhB-3ti8A:
undetectable		 3czhB-3ti8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		5 ALA A 116
VAL A 118
VAL A  43
ILE A  45
MET A  65
 None
 1.11A 3czhB-3tisA:
undetectable		 3czhB-3tisA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wb1 UNCHARACTERIZED
PROTEIN MJ0488

(Methanocaldococcus
jannaschii) 		PF11576
(DUF3236) 		5 LEU A  69
ASN A  46
ALA A  76
VAL A 115
ILE A  71
 None
 1.10A 3czhB-3wb1A:
undetectable		 3czhB-3wb1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		5 THR A  11
PHE A 129
ALA A  94
ALA A 117
THR A 122
 None
 0.94A 3czhB-3wvaA:
undetectable		 3czhB-3wvaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		5 LEU A 465
PHE A 539
ALA A 514
VAL A 543
VAL A 490
 None
 1.13A 3czhB-3zilA:
undetectable		 3czhB-3zilA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 LEU A 106
ALA A  46
ALA A  22
VAL A  38
THR A  41
 None
 1.11A 3czhB-3zizA:
undetectable		 3czhB-3zizA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.10A 3czhB-4a11B:
undetectable		 3czhB-4a11B:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		5 LEU A  54
ALA A 177
ALA A 159
VAL A 157
ILE A  52
 None
 1.12A 3czhB-4aodA:
undetectable		 3czhB-4aodA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 541
ASN A 591
ALA A 476
ILE A 539
THR A 558
 None
 1.09A 3czhB-4arxA:
undetectable		 3czhB-4arxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmh ACETYLTRANSFERASE

(Streptomyces
sviceus) 		PF00583
(Acetyltransf_1) 		5 THR A  78
LEU A 190
ALA A 100
MET A 204
THR A 206
 None
 1.08A 3czhB-4bmhA:
undetectable		 3czhB-4bmhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 LEU B 138
ALA B 347
THR B 146
VAL B 112
ILE B 114
 None
 1.13A 3czhB-4cakB:
undetectable		 3czhB-4cakB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 168
ASN A 306
ALA A 122
VAL A  62
ILE A 164
 None
 1.09A 3czhB-4ewpA:
undetectable		 3czhB-4ewpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 225
ALA A 147
ALA A 218
ILE A 186
THR A 176
 None
 1.12A 3czhB-4eyeA:
undetectable		 3czhB-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		no annotation 5 ALA B1719
VAL B1807
ILE B1709
MET B1803
THR B1804
 None
 1.15A 3czhB-4f7gB:
undetectable		 3czhB-4f7gB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 THR A 255
LEU A 374
ALA A 324
ALA A 327
VAL A 329
 None
 1.13A 3czhB-4fwwA:
undetectable		 3czhB-4fwwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 ALA A 262
ALA A 266
VAL A 267
ILE A 213
THR A 239
 None
CL  A 507 ( 3.9A)
None
None
None
 1.10A 3czhB-4hw6A:
undetectable		 3czhB-4hw6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liz ACTIN-BINDING
PROTEIN,
COFILIN/TROPOMYOSIN
FAMILY PROTEIN,
PUTATIVE

(Entamoeba
histolytica) 		PF00241
(Cofilin_ADF) 		5 LEU A  38
ALA A  59
ALA A  54
VAL A  51
VAL A  97
 None
EPE  A 201 ( 3.8A)
None
None
None
 1.11A 3czhB-4lizA:
undetectable		 3czhB-4lizA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  93
PHE A 162
ALA A  64
VAL A  73
ILE A  58
 None
 1.10A 3czhB-4m69A:
undetectable		 3czhB-4m69A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 PHE A 221
ALA A 212
ALA A 257
ILE A 137
THR A 180
 None
 1.10A 3czhB-4nenA:
undetectable		 3czhB-4nenA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 LEU A 284
ALA A 366
VAL A 491
VAL A 358
ILE A 420
 None
 1.03A 3czhB-4o7dA:
undetectable		 3czhB-4o7dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE

(Brucella
melitensis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 THR A 227
LEU A 266
PHE A 262
VAL A 248
THR A 145
 None
 1.14A 3czhB-4oh7A:
undetectable		 3czhB-4oh7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		5 ALA A 281
ALA A  60
VAL A  65
VAL A 130
ILE A  96
 None
 1.07A 3czhB-4ry8A:
undetectable		 3czhB-4ry8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 THR A 359
LEU A 344
THR A 353
VAL A 259
THR A 280
 None
 1.05A 3czhB-4u48A:
undetectable		 3czhB-4u48A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 128
PHE A 318
ALA A 378
ALA A 154
THR A 352
 3G6  A 402 ( 4.3A)
None
3G6  A 402 (-4.1A)
None
None
 1.02A 3czhB-4ubtA:
undetectable		 3czhB-4ubtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 541
ASN A 591
ALA A 476
ILE A 539
THR A 558
 None
 1.14A 3czhB-4w8jA:
undetectable		 3czhB-4w8jA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		5 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.14A 3czhB-4xz7A:
undetectable		 3czhB-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		5 LEU A 352
THR A 361
VAL A 267
ILE A 211
THR A 288
 None
 1.11A 3czhB-4zjgA:
undetectable		 3czhB-4zjgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 LEU A 289
ALA A 371
VAL A 496
VAL A 363
ILE A 425
 None
 1.02A 3czhB-5d3oA:
undetectable		 3czhB-5d3oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		5 LEU A 270
ALA A 257
ALA A 241
VAL A 239
ILE A 217
 None
 1.12A 3czhB-5danA:
undetectable		 3czhB-5danA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		5 ALA A 224
ALA A 202
VAL A 138
ILE A 136
THR A 237
 None
 1.07A 3czhB-5fl3A:
undetectable		 3czhB-5fl3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 THR A  81
ALA A  77
THR A 164
VAL A  24
ILE A  22
 None
 1.06A 3czhB-5habA:
undetectable		 3czhB-5habA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 299
PHE A 307
ALA A 282
ALA A 305
ILE A 276
 None
 1.15A 3czhB-5hdhA:
undetectable		 3czhB-5hdhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A 165
ALA A 155
THR A 177
ILE A 190
THR A 181
 None
 1.13A 3czhB-5l0zA:
undetectable		 3czhB-5l0zA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 157
ALA B 174
ALA B 249
VAL B 402
ILE B 155
 None
 1.09A 3czhB-5my0B:
undetectable		 3czhB-5my0B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 5 LEU A  78
ALA A 155
VAL A 152
THR A  48
ILE A  83
 None
 1.02A 3czhB-5oeeA:
undetectable		 3czhB-5oeeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		5 LEU E 145
ALA E 203
VAL E 221
THR E 215
ILE E 182
 None
 0.97A 3czhB-5of4E:
undetectable		 3czhB-5of4E:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ALA A 171
ALA A 146
VAL A 144
THR A 161
ILE A 155
 None
 1.04A 3czhB-5ujsA:
undetectable		 3czhB-5ujsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		5 LEU A 263
ALA A  49
VAL A  26
ILE A 259
THR A  54
 None
 1.08A 3czhB-5uveA:
undetectable		 3czhB-5uveA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 LEU A 576
PHE A 522
ALA A 563
VAL A 564
ILE A 533
 None
 1.05A 3czhB-5ve8A:
undetectable		 3czhB-5ve8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 ALA A 257
ALA A 213
VAL A 276
ILE A 278
THR A 261
 None
 1.05A 3czhB-5w19A:
undetectable		 3czhB-5w19A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 5 LEU C 392
ASN C 395
VAL C 373
ILE C 362
THR C 370
 None
 0.94A 3czhB-5wqlC:
undetectable		 3czhB-5wqlC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 THR A 167
ALA A 153
ALA A 212
VAL A  89
ILE A  91
 None
 1.03A 3czhB-5zqzA:
undetectable		 3czhB-5zqzA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c96 TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Mus musculus) 		no annotation 5 PHE A 209
ALA A 148
VAL A 152
ILE A 584
THR A 577
 None
 1.15A 3czhB-6c96A:
undetectable		 3czhB-6c96A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 5 LEU A 428
ALA A 284
VAL A 415
ILE A 424
THR A 414
 None
 1.04A 3czhB-6duxA:
undetectable		 3czhB-6duxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2

(Sulfobacillus) 		no annotation 5 ALA B 239
ALA B 268
THR B 107
VAL B  75
THR B 105
 None
 1.13A 3czhB-6eqnB:
undetectable		 3czhB-6eqnB:
10.71