SIMILAR PATTERNS OF AMINO ACIDS FOR 3CZH_A_D2VA602_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2a | PHOSPHOLIPASE A2 (Gloydius halys) |
PF00068(Phospholip_A2_1) | 3 | LEU A 110GLU A 13ILE A 9 | None | 0.55A | 3czhA-1a2aA:undetectable | 3czhA-1a2aA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjx | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Pseudomonasfluorescens) |
PF00903(Glyoxalase)PF14696(Glyoxalase_5) | 3 | LEU A 113GLU A 110ILE A 139 | None | 0.59A | 3czhA-1cjxA:0.0 | 3czhA-1cjxA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iqq | S3-RNASE (Pyrus pyrifolia) |
PF00445(Ribonuclease_T2) | 3 | LEU A 164GLU A 139ILE A 142 | None | 0.49A | 3czhA-1iqqA:0.0 | 3czhA-1iqqA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5y | TRANSCRIPTIONALREGULATOR, BIOTINREPRESSOR FAMILY (Thermotogamaritima) |
PF02829(3H)PF08279(HTH_11) | 3 | LEU A 171GLU A 164ILE A 161 | None | 0.61A | 3czhA-1j5yA:0.1 | 3czhA-1j5yA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 3 | LEU A 594GLU A 568ILE A 572 | None | 0.58A | 3czhA-1kblA:undetectable | 3czhA-1kblA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzl | RIBOFLAVIN SYNTHASE (Schizosaccharomycespombe) |
PF00677(Lum_binding) | 3 | LEU A 33GLU A 28ILE A 27 | None | 0.50A | 3czhA-1kzlA:0.0 | 3czhA-1kzlA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lry | PEPTIDE DEFORMYLASE (Pseudomonasaeruginosa) |
PF01327(Pep_deformylase) | 3 | LEU A 62GLU A 134ILE A 131 | NoneBB2 A 170 (-2.6A)None | 0.59A | 3czhA-1lryA:0.0 | 3czhA-1lryA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m33 | BIOH PROTEIN (Escherichiacoli) |
PF00561(Abhydrolase_1) | 3 | LEU A 42GLU A 35ILE A 32 | None | 0.59A | 3czhA-1m33A:0.0 | 3czhA-1m33A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mc2 | ACUTOHAEMONLYSIN (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 3 | LEU A1110GLU A1012ILE A1009 | None | 0.56A | 3czhA-1mc2A:0.0 | 3czhA-1mc2A:13.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1np7 | DNA PHOTOLYASE (Synechocystissp. PCC 6803) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | LEU A 233GLU A 269ILE A 266 | None | 0.53A | 3czhA-1np7A:0.0 | 3czhA-1np7A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p0r | UBIQUITIN-LIKE 5 (Homo sapiens) |
PF00240(ubiquitin) | 3 | LEU A 68GLU A 3ILE A 2 | None | 0.56A | 3czhA-1p0rA:undetectable | 3czhA-1p0rA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q9h | CELLOBIOHYDROLASE ICATALYTIC DOMAIN (Rasamsoniaemersonii) |
PF00840(Glyco_hydro_7) | 3 | LEU A 300GLU A 302ILE A 329 | None | 0.61A | 3czhA-1q9hA:undetectable | 3czhA-1q9hA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyc | PHENYLCOUMARANBENZYLIC ETHERREDUCTASE PT1 (Pinus taeda) |
PF05368(NmrA) | 3 | LEU A 164GLU A 232ILE A 235 | None | 0.58A | 3czhA-1qycA:undetectable | 3czhA-1qycA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6v | SUBTILISIN-LIKESERINE PROTEASE (Fervidobacteriumpennivorans) |
PF00082(Peptidase_S8) | 3 | LEU A 32GLU A 101ILE A 42 | None | 0.57A | 3czhA-1r6vA:undetectable | 3czhA-1r6vA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg5 | ORF, HYPOTHETICALPROTEIN (Escherichiacoli) |
PF07073(ROF) | 3 | LEU A 38GLU A 31ILE A 70 | None | 0.59A | 3czhA-1sg5A:undetectable | 3czhA-1sg5A:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1smk | MALATEDEHYDROGENASE,GLYOXYSOMAL (Citrulluslanatus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | LEU A 186GLU A 173ILE A 170 | None | 0.60A | 3czhA-1smkA:undetectable | 3czhA-1smkA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sv6 | 2-KETO-4-PENTENOATEHYDRATASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 3 | LEU A 176GLU A 250ILE A 249 | None | 0.52A | 3czhA-1sv6A:undetectable | 3czhA-1sv6A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpd | TARTRONATESEMIALDEHYDEREDUCTASE (Salmonellaenterica) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 3 | LEU A 22GLU A 47ILE A 42 | None | 0.56A | 3czhA-1vpdA:undetectable | 3czhA-1vpdA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdu | TRAS1 ORF2P (Bombyx mori) |
PF14529(Exo_endo_phos_2) | 3 | LEU A 95GLU A 119ILE A 120 | None | 0.58A | 3czhA-1wduA:undetectable | 3czhA-1wduA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wnb | PUTATIVE BETAINEALDEHYDEDEHYDROGENASE (Escherichiacoli) |
PF00171(Aldedh) | 3 | LEU A 247GLU A 230ILE A 233 | None | 0.57A | 3czhA-1wnbA:undetectable | 3czhA-1wnbA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zu2 | MITOCHONDRIAL IMPORTRECEPTOR SUBUNITTOM20-3 (Arabidopsisthaliana) |
PF06552(TOM20_plant) | 3 | LEU A 42GLU A 59ILE A 61 | None | 0.50A | 3czhA-1zu2A:undetectable | 3czhA-1zu2A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cic | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDE HYDROLASE (Campylobacterjejuni) |
PF08761(dUTPase_2) | 3 | LEU A 151GLU A 104ILE A 101 | None | 0.53A | 3czhA-2cicA:undetectable | 3czhA-2cicA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpg | GLUCOSE 6-PHOSPHATEDEHYDROGENASE (Leuconostocmesenteroides) |
PF00479(G6PD_N)PF02781(G6PD_C) | 3 | LEU A 35GLU A 416ILE A 419 | None | 0.54A | 3czhA-2dpgA:undetectable | 3czhA-2dpgA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dy0 | ADENINEPHOSPHORIBOSYLTRANSFERASE (Escherichiacoli) |
PF00156(Pribosyltran) | 3 | LEU A 129GLU A 168ILE A 172 | None | 0.55A | 3czhA-2dy0A:undetectable | 3czhA-2dy0A:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dy3 | ALANINE RACEMASE (Corynebacteriumglutamicum) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | LEU A 189GLU A 151ILE A 150 | None | 0.56A | 3czhA-2dy3A:undetectable | 3czhA-2dy3A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewy | BETA-SECRETASE 2 (Homo sapiens) |
PF00026(Asp) | 3 | LEU A 149GLU A 98ILE A 115 | None | 0.59A | 3czhA-2ewyA:undetectable | 3czhA-2ewyA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2id0 | EXORIBONUCLEASE 2 (Escherichiacoli) |
PF00575(S1)PF00773(RNB)PF08206(OB_RNB) | 3 | LEU A 224GLU A 391ILE A 388 | None | 0.47A | 3czhA-2id0A:undetectable | 3czhA-2id0A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iut | DNA TRANSLOCASE FTSK (Pseudomonasaeruginosa) |
PF01580(FtsK_SpoIIIE) | 3 | LEU A 673GLU A 412ILE A 413 | None | 0.53A | 3czhA-2iutA:undetectable | 3czhA-2iutA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4d | CRYPTOCHROME DASH (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | LEU A 269GLU A 305ILE A 302 | None | 0.56A | 3czhA-2j4dA:undetectable | 3czhA-2j4dA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m4n | PROTEIN AFD-1,ISOFORM A (Caenorhabditiselegans) |
PF00788(RA) | 3 | LEU A 7GLU A 26ILE A 27 | None | 0.60A | 3czhA-2m4nA:undetectable | 3czhA-2m4nA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwz | MALATE DEHYDROGENASE (Escherichiacoli) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | LEU A 143GLU A 130ILE A 127 | None | 0.55A | 3czhA-2pwzA:undetectable | 3czhA-2pwzA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkb | RIBONUCLEASE H1 (Homo sapiens) |
PF00075(RNase_H) | 3 | LEU A 176GLU A 186ILE A 187 | None A C 11 ( 3.9A)None | 0.59A | 3czhA-2qkbA:undetectable | 3czhA-2qkbA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzz | N-METHYL-L-TRYPTOPHAN OXIDASE (Escherichiacoli) |
PF01266(DAO) | 3 | LEU A 207GLU A 185ILE A 184 | FAD A1373 (-3.9A)NoneNone | 0.51A | 3czhA-2uzzA:undetectable | 3czhA-2uzzA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v40 | ADENYLOSUCCINATESYNTHETASE ISOZYME 2 (Homo sapiens) |
PF00709(Adenylsucc_synt) | 3 | LEU A 405GLU A 435ILE A 432 | None | 0.60A | 3czhA-2v40A:undetectable | 3czhA-2v40A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7g | UROCANATE HYDRATASE (Pseudomonasputida) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 3 | LEU A 223GLU A 250ILE A 247 | None | 0.60A | 3czhA-2v7gA:undetectable | 3czhA-2v7gA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2voa | EXODEOXYRIBONUCLEASEIII (Archaeoglobusfulgidus) |
PF03372(Exo_endo_phos) | 3 | LEU A 2GLU A 72ILE A 96 | None | 0.47A | 3czhA-2voaA:undetectable | 3czhA-2voaA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvf | MAJOR CAPSID PROTEINP2 (Pseudoalteromonasvirus PM2) |
no annotation | 3 | LEU A 197GLU A 160ILE A 246 | None | 0.58A | 3czhA-2vvfA:undetectable | 3czhA-2vvfA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wlb | ELECTRON TRANSFERPROTEIN 1,MITOCHONDRIAL (Schizosaccharomycespombe) |
PF00111(Fer2) | 3 | LEU A 606GLU A 534ILE A 533 | None | 0.46A | 3czhA-2wlbA:undetectable | 3czhA-2wlbA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvi | MITOTIC CHECKPOINTSERINE/THREONINE-PROTEIN KINASE BUB1BETA (Homo sapiens) |
PF08311(Mad3_BUB1_I) | 3 | LEU A 189GLU A 177ILE A 174 | None | 0.56A | 3czhA-2wviA:undetectable | 3czhA-2wviA:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6p | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Aquifexaeolicus) |
PF02348(CTP_transf_3) | 3 | LEU A 120GLU A 102ILE A 104 | None | 0.60A | 3czhA-2y6pA:undetectable | 3czhA-2y6pA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y75 | HTH-TYPETRANSCRIPTIONALREGULATOR CYMR (Bacillussubtilis) |
PF02082(Rrf2) | 3 | LEU A 121GLU A 17ILE A 14 | None | 0.60A | 3czhA-2y75A:undetectable | 3czhA-2y75A:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3blx | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT 2 (Saccharomycescerevisiae) |
PF00180(Iso_dh) | 3 | LEU B 298GLU B 28ILE B 27 | None | 0.53A | 3czhA-3blxB:undetectable | 3czhA-3blxB:21.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c6g | CYTOCHROME P450 2R1 (Homo sapiens) |
PF00067(p450) | 3 | LEU A 257GLU A 306ILE A 309 | NoneVD3 A 701 ( 4.8A)None | 0.12A | 3czhA-3c6gA:65.1 | 3czhA-3c6gA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c85 | PUTATIVEGLUTATHIONE-REGULATED POTASSIUM-EFFLUXSYSTEM PROTEIN KEFB (Vibrioparahaemolyticus) |
PF02254(TrkA_N) | 3 | LEU A 141GLU A 158ILE A 155 | None | 0.54A | 3czhA-3c85A:undetectable | 3czhA-3c85A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8v | PUTATIVEACETYLTRANSFERASE (Desulfovibrioalaskensis) |
no annotation | 3 | LEU A 384GLU A 367ILE A 348 | None | 0.60A | 3czhA-3c8vA:undetectable | 3czhA-3c8vA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3caw | O-SUCCINYLBENZOATESYNTHASE (Bdellovibriobacteriovorus) |
no annotation | 3 | LEU A 63GLU A 73ILE A 76 | None | 0.57A | 3czhA-3cawA:undetectable | 3czhA-3cawA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgw | LPPG:FO2-PHOSPHO-L-LACTATETRANSFERASE (Methanosarcinamazei) |
PF01933(UPF0052) | 3 | LEU A 26GLU A 19ILE A 20 | None | 0.52A | 3czhA-3cgwA:undetectable | 3czhA-3cgwA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcl | TM1086 (Thermotogamaritima) |
PF14505(DUF4438) | 3 | LEU A 78GLU A 16ILE A 130 | None | 0.53A | 3czhA-3dclA:undetectable | 3czhA-3dclA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emq | ENDO-1,4-BETA-XYLANASE (Paenibacillusbarcinonensis) |
PF00331(Glyco_hydro_10) | 3 | LEU A 150GLU A 137ILE A 143 | None | 0.56A | 3czhA-3emqA:undetectable | 3czhA-3emqA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g9q | FERRICHROME-BINDINGPROTEIN (Bacillussubtilis) |
PF01497(Peripla_BP_2) | 3 | LEU A 114GLU A 100ILE A 102 | None | 0.60A | 3czhA-3g9qA:undetectable | 3czhA-3g9qA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn7 | UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE (Psychrobacterarcticus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | LEU A 439GLU A 402ILE A 401 | None | 0.54A | 3czhA-3hn7A:undetectable | 3czhA-3hn7A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jtx | AMINOTRANSFERASE (Neisseriameningitidis) |
PF00155(Aminotran_1_2) | 3 | LEU A 111GLU A 142ILE A 143 | None | 0.56A | 3czhA-3jtxA:undetectable | 3czhA-3jtxA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfo | NUCLEOPORIN NUP133 (Saccharomycescerevisiae) |
no annotation | 3 | LEU A1021GLU A 957ILE A 960 | None | 0.60A | 3czhA-3kfoA:undetectable | 3czhA-3kfoA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l39 | PUTATIVE PHOU-LIKEPHOSPHATE REGULATORYPROTEIN (Bacteroidesthetaiotaomicron) |
PF01865(PhoU_div) | 3 | LEU A 34GLU A 192ILE A 189 | NonePO4 A 217 ( 4.9A)None | 0.52A | 3czhA-3l39A:undetectable | 3czhA-3l39A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llx | PREDICTED AMINO ACIDALDOLASE OR RACEMASE (Idiomarinaloihiensis) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 3 | LEU A 168GLU A 203ILE A 207 | None | 0.54A | 3czhA-3llxA:undetectable | 3czhA-3llxA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mnf | PAC2 FAMILY PROTEIN (Streptomycesavermitilis) |
PF09754(PAC2) | 3 | LEU A 36GLU A 210ILE A 213 | None | 0.54A | 3czhA-3mnfA:undetectable | 3czhA-3mnfA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngx | BIFUNCTIONAL PROTEINFOLD (Thermoplasmaacidophilum) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 3 | LEU A 94GLU A 91ILE A 33 | None | 0.54A | 3czhA-3ngxA:undetectable | 3czhA-3ngxA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 3 | LEU A 491GLU A 382ILE A 381 | None | 0.57A | 3czhA-3opyA:undetectable | 3czhA-3opyA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pih | UVRABC SYSTEMPROTEIN A (Thermotogamaritima) |
PF00005(ABC_tran) | 3 | LEU A 732GLU A 728ILE A 727 | None | 0.48A | 3czhA-3pihA:undetectable | 3czhA-3pihA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rac | HISTIDINE-TRNALIGASE (Alicyclobacillusacidocaldarius) |
PF13393(tRNA-synt_His) | 3 | LEU A 44GLU A 352ILE A 327 | None | 0.57A | 3czhA-3racA:undetectable | 3czhA-3racA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr1 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Coxiellaburnetii) |
PF00275(EPSP_synthase) | 3 | LEU A 357GLU A 379ILE A 405 | None | 0.58A | 3czhA-3tr1A:undetectable | 3czhA-3tr1A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tx8 | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Corynebacteriumglutamicum) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | LEU A 225GLU A 172ILE A 171 | None | 0.58A | 3czhA-3tx8A:undetectable | 3czhA-3tx8A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3urg | ALR1010 PROTEIN (Nostoc sp. PCC7120) |
PF11535(Calci_bind_CcbP) | 3 | LEU A 117GLU A 101ILE A 100 | None | 0.59A | 3czhA-3urgA:undetectable | 3czhA-3urgA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v64 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 3 | LEU C 597GLU C 580ILE C 592 | None | 0.55A | 3czhA-3v64C:undetectable | 3czhA-3v64C:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v65 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 3 | LEU B 597GLU B 580ILE B 592 | None | 0.48A | 3czhA-3v65B:undetectable | 3czhA-3v65B:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2w | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C)PF16739(CARD_2) | 3 | LEU A 129GLU A 155ILE A 154 | None | 0.60A | 3czhA-4a2wA:undetectable | 3czhA-4a2wA:19.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4are | COLLAGENASE G (Hathewayahistolytica) |
PF01752(Peptidase_M9)PF08453(Peptidase_M9_N) | 3 | LEU A 322GLU A 294ILE A 293 | None | 0.57A | 3czhA-4areA:undetectable | 3czhA-4areA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxs | VENOM PROTHROMBINACTIVATORPSEUTARIN-CNON-CATALYTICSUBUNIT (Pseudonajatextilis) |
PF00754(F5_F8_type_C)PF07732(Cu-oxidase_3) | 3 | LEU V1149GLU V1236ILE V1183 | None | 0.57A | 3czhA-4bxsV:undetectable | 3czhA-4bxsV:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8q | DNA TOPOISOMERASE2-ASSOCIATED PROTEINPAT1 (Saccharomycescerevisiae) |
PF09770(PAT1) | 3 | LEU H 511GLU H 488ILE H 489 | None | 0.59A | 3czhA-4c8qH:undetectable | 3czhA-4c8qH:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4co6 | NUCLEOPROTEIN (Nipahhenipavirus) |
PF00973(Paramyxo_ncap) | 3 | LEU A 92GLU A 98ILE A 35 | None | 0.59A | 3czhA-4co6A:undetectable | 3czhA-4co6A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e0b | MALATE DEHYDROGENASE (Vibriovulnificus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | LEU A 143GLU A 130ILE A 127 | None | 0.53A | 3czhA-4e0bA:undetectable | 3czhA-4e0bA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | LEU B 631GLU B 602ILE B 596 | None | 0.53A | 3czhA-4f92B:undetectable | 3czhA-4f92B:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwt | ELONGATION FACTORTS, ELONGATIONFACTOR TU, LINKER, QBETA REPLICASE (Escherichiacoli;Escherichiavirus Qbeta) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2)PF03431(RNA_replicase_B) | 3 | LEU A 934GLU A1026ILE A1029 | NoneGTP A2501 (-2.5A)None | 0.56A | 3czhA-4fwtA:undetectable | 3czhA-4fwtA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grx | AMINOTRANSFERASE (Paracoccusdenitrificans) |
PF00202(Aminotran_3) | 3 | LEU A 179GLU A 212ILE A 209 | None | 0.48A | 3czhA-4grxA:undetectable | 3czhA-4grxA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwf | BAG FAMILY MOLECULARCHAPERONE REGULATOR3 (Arabidopsisthaliana) |
PF02179(BAG) | 3 | LEU A 171GLU A 157ILE A 160 | None | 0.60A | 3czhA-4hwfA:undetectable | 3czhA-4hwfA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8o | TOXIN RNLA (Escherichiacoli) |
PF15935(RnlA_toxin) | 3 | LEU A 85GLU A 20ILE A 17 | None | 0.42A | 3czhA-4i8oA:undetectable | 3czhA-4i8oA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iis | BETA-1,3-GLUCANASEFORM 'RRII GLN 2' (Heveabrasiliensis) |
PF00332(Glyco_hydro_17) | 3 | LEU A 139GLU A 94ILE A 95 | None | 0.57A | 3czhA-4iisA:undetectable | 3czhA-4iisA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxu | PUTATIVEAMINOTRANSFERASE (Sinorhizobiummeliloti) |
PF01063(Aminotran_4) | 3 | LEU A 239GLU A 236ILE A 235 | None | 0.59A | 3czhA-4jxuA:undetectable | 3czhA-4jxuA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4koa | 1,5-ANHYDRO-D-FRUCTOSE REDUCTASE (Sinorhizobiummeliloti) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 100GLU A 330ILE A 329 | None | 0.50A | 3czhA-4koaA:undetectable | 3czhA-4koaA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nng | 30S RIBOSOMALPROTEIN S1 (Mycobacteriumtuberculosis) |
PF00575(S1) | 3 | LEU A 360GLU A 318ILE A 317 | None | 0.54A | 3czhA-4nngA:undetectable | 3czhA-4nngA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7y | METHIONINEGAMMA-LYASE (Citrobacterfreundii) |
PF01053(Cys_Met_Meta_PP) | 3 | LEU A 301GLU A 169ILE A 168 | None | 0.60A | 3czhA-4p7yA:undetectable | 3czhA-4p7yA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pev | MEMBRANE LIPOPROTEINFAMILY PROTEIN (Aeropyrumpernix) |
PF02608(Bmp) | 3 | LEU A 323GLU A 362ILE A 364 | None | 0.56A | 3czhA-4pevA:undetectable | 3czhA-4pevA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmw | DIS3-LIKEEXONUCLEASE 2 (Mus musculus) |
PF00773(RNB)PF17216(Rrp44_CSD1) | 3 | LEU A 849GLU A 326ILE A 327 | None | 0.60A | 3czhA-4pmwA:undetectable | 3czhA-4pmwA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmk | TYPE III SECRETIONSYSTEM EFFECTORPROTEIN EXOU (Pseudomonasfluorescens) |
PF01734(Patatin) | 3 | LEU A 117GLU A 179ILE A 176 | BME A 700 ( 4.9A)NoneNone | 0.58A | 3czhA-4qmkA:undetectable | 3czhA-4qmkA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0m | MCYG PROTEIN (Microcystisaeruginosa) |
no annotation | 3 | LEU B 158GLU B 63ILE B 67 | None | 0.56A | 3czhA-4r0mB:undetectable | 3czhA-4r0mB:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r12 | PUTATIVEUNCHARACTERIZEDPROTEIN (Dictyosteliumpurpureum) |
PF05450(Nicastrin) | 3 | LEU A 262GLU A 342ILE A 341 | None | 0.60A | 3czhA-4r12A:undetectable | 3czhA-4r12A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rld | ASPARTIC PROTEASEBLA G 2 (Blattellagermanica) |
PF00026(Asp) | 3 | LEU A 131GLU A 86ILE A 85 | None | 0.54A | 3czhA-4rldA:undetectable | 3czhA-4rldA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u2x | IMPORTIN SUBUNITALPHA-6 (Homo sapiens) |
PF00514(Arm)PF16186(Arm_3) | 3 | LEU D 336GLU D 358ILE D 355 | None | 0.52A | 3czhA-4u2xD:undetectable | 3czhA-4u2xD:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 3 | LEU A 21GLU A 12ILE A 9 | None | 0.58A | 3czhA-4xriA:undetectable | 3czhA-4xriA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Homo sapiens) |
PF04389(Peptidase_M28) | 3 | LEU A 284GLU A 277ILE A 274 | None | 0.53A | 3czhA-4yu9A:undetectable | 3czhA-4yu9A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zlr | BRAIN TUMOR PROTEIN (Drosophilamelanogaster) |
PF01436(NHL) | 3 | LEU A1009GLU A 970ILE A 971 | None | 0.60A | 3czhA-4zlrA:undetectable | 3czhA-4zlrA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr8 | UROPORPHYRINOGENDECARBOXYLASE (Acinetobacterbaumannii) |
PF01208(URO-D) | 3 | LEU A 14GLU A 237ILE A 243 | None | 0.49A | 3czhA-4zr8A:undetectable | 3czhA-4zr8A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqn | BOTULINUM NEUROTOXINTYPE D,BOTULINUMNEUROTOXIN TYPE D (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 3 | LEU A 276GLU A 869ILE A 866 | None | 0.59A | 3czhA-5bqnA:undetectable | 3czhA-5bqnA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5diz | PROTEINACEOUS RNASEP 2 (Arabidopsisthaliana) |
PF16953(PRORP)PF17177(PPR_long) | 3 | LEU A 308GLU A 448ILE A 446 | None | 0.55A | 3czhA-5dizA:undetectable | 3czhA-5dizA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dk6 | 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Colwelliapsychrerythraea) |
PF01048(PNP_UDP_1) | 3 | LEU A 38GLU A 18ILE A 15 | None | 0.56A | 3czhA-5dk6A:undetectable | 3czhA-5dk6A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej0 | ENVELOPE PROTEIN H3 (Vaccinia virus) |
PF03213(Pox_P35) | 3 | LEU A 208GLU A 201ILE A 198 | None | 0.55A | 3czhA-5ej0A:undetectable | 3czhA-5ej0A:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jo7 | VETISPIRADIENESYNTHASE 1 (Hyoscyamusmuticus) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | LEU A 158GLU A 174ILE A 171 | None | 0.54A | 3czhA-5jo7A:undetectable | 3czhA-5jo7A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k5z | PARA (Sulfolobus sp.NOB8H2) |
PF13614(AAA_31) | 3 | LEU A 161GLU A 306ILE A 303 | None | 0.56A | 3czhA-5k5zA:undetectable | 3czhA-5k5zA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m9n | TUDORDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00567(TUDOR) | 3 | LEU A 666GLU A 621ILE A 623 | None | 0.59A | 3czhA-5m9nA:undetectable | 3czhA-5m9nA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uja | BOVINE MULTIDRUGRESISTANCE PROTEIN 1(MRP1),MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | LEU A 753GLU A 760ILE A 761 | None | 0.58A | 3czhA-5ujaA:undetectable | 3czhA-5ujaA:16.08 |