SIMILAR PATTERNS OF AMINO ACIDS FOR 3CZH_A_D2VA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2a PHOSPHOLIPASE A2

(Gloydius halys)
PF00068
(Phospholip_A2_1)
3 LEU A 110
GLU A  13
ILE A   9
None
0.55A 3czhA-1a2aA:
undetectable
3czhA-1a2aA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Pseudomonas
fluorescens)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
3 LEU A 113
GLU A 110
ILE A 139
None
0.59A 3czhA-1cjxA:
0.0
3czhA-1cjxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqq S3-RNASE

(Pyrus pyrifolia)
PF00445
(Ribonuclease_T2)
3 LEU A 164
GLU A 139
ILE A 142
None
0.49A 3czhA-1iqqA:
0.0
3czhA-1iqqA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY


(Thermotoga
maritima)
PF02829
(3H)
PF08279
(HTH_11)
3 LEU A 171
GLU A 164
ILE A 161
None
0.61A 3czhA-1j5yA:
0.1
3czhA-1j5yA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE


([Clostridium]
symbiosum)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
3 LEU A 594
GLU A 568
ILE A 572
None
0.58A 3czhA-1kblA:
undetectable
3czhA-1kblA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe)
PF00677
(Lum_binding)
3 LEU A  33
GLU A  28
ILE A  27
None
0.50A 3czhA-1kzlA:
0.0
3czhA-1kzlA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lry PEPTIDE DEFORMYLASE

(Pseudomonas
aeruginosa)
PF01327
(Pep_deformylase)
3 LEU A  62
GLU A 134
ILE A 131
None
BB2  A 170 (-2.6A)
None
0.59A 3czhA-1lryA:
0.0
3czhA-1lryA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli)
PF00561
(Abhydrolase_1)
3 LEU A  42
GLU A  35
ILE A  32
None
0.59A 3czhA-1m33A:
0.0
3czhA-1m33A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus)
PF00068
(Phospholip_A2_1)
3 LEU A1110
GLU A1012
ILE A1009
None
0.56A 3czhA-1mc2A:
0.0
3czhA-1mc2A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 LEU A 233
GLU A 269
ILE A 266
None
0.53A 3czhA-1np7A:
0.0
3czhA-1np7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0r UBIQUITIN-LIKE 5

(Homo sapiens)
PF00240
(ubiquitin)
3 LEU A  68
GLU A   3
ILE A   2
None
0.56A 3czhA-1p0rA:
undetectable
3czhA-1p0rA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN


(Rasamsonia
emersonii)
PF00840
(Glyco_hydro_7)
3 LEU A 300
GLU A 302
ILE A 329
None
0.61A 3czhA-1q9hA:
undetectable
3czhA-1q9hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1


(Pinus taeda)
PF05368
(NmrA)
3 LEU A 164
GLU A 232
ILE A 235
None
0.58A 3czhA-1qycA:
undetectable
3czhA-1qycA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE


(Fervidobacterium
pennivorans)
PF00082
(Peptidase_S8)
3 LEU A  32
GLU A 101
ILE A  42
None
0.57A 3czhA-1r6vA:
undetectable
3czhA-1r6vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg5 ORF, HYPOTHETICAL
PROTEIN


(Escherichia
coli)
PF07073
(ROF)
3 LEU A  38
GLU A  31
ILE A  70
None
0.59A 3czhA-1sg5A:
undetectable
3czhA-1sg5A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL


(Citrullus
lanatus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 LEU A 186
GLU A 173
ILE A 170
None
0.60A 3czhA-1smkA:
undetectable
3czhA-1smkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
3 LEU A 176
GLU A 250
ILE A 249
None
0.52A 3czhA-1sv6A:
undetectable
3czhA-1sv6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpd TARTRONATE
SEMIALDEHYDE
REDUCTASE


(Salmonella
enterica)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
3 LEU A  22
GLU A  47
ILE A  42
None
0.56A 3czhA-1vpdA:
undetectable
3czhA-1vpdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori)
PF14529
(Exo_endo_phos_2)
3 LEU A  95
GLU A 119
ILE A 120
None
0.58A 3czhA-1wduA:
undetectable
3czhA-1wduA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE


(Escherichia
coli)
PF00171
(Aldedh)
3 LEU A 247
GLU A 230
ILE A 233
None
0.57A 3czhA-1wnbA:
undetectable
3czhA-1wnbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu2 MITOCHONDRIAL IMPORT
RECEPTOR SUBUNIT
TOM20-3


(Arabidopsis
thaliana)
PF06552
(TOM20_plant)
3 LEU A  42
GLU A  59
ILE A  61
None
0.50A 3czhA-1zu2A:
undetectable
3czhA-1zu2A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE


(Campylobacter
jejuni)
PF08761
(dUTPase_2)
3 LEU A 151
GLU A 104
ILE A 101
None
0.53A 3czhA-2cicA:
undetectable
3czhA-2cicA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE


(Leuconostoc
mesenteroides)
PF00479
(G6PD_N)
PF02781
(G6PD_C)
3 LEU A  35
GLU A 416
ILE A 419
None
0.54A 3czhA-2dpgA:
undetectable
3czhA-2dpgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Escherichia
coli)
PF00156
(Pribosyltran)
3 LEU A 129
GLU A 168
ILE A 172
None
0.55A 3czhA-2dy0A:
undetectable
3czhA-2dy0A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 LEU A 189
GLU A 151
ILE A 150
None
0.56A 3czhA-2dy3A:
undetectable
3czhA-2dy3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens)
PF00026
(Asp)
3 LEU A 149
GLU A  98
ILE A 115
None
0.59A 3czhA-2ewyA:
undetectable
3czhA-2ewyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli)
PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB)
3 LEU A 224
GLU A 391
ILE A 388
None
0.47A 3czhA-2id0A:
undetectable
3czhA-2id0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa)
PF01580
(FtsK_SpoIIIE)
3 LEU A 673
GLU A 412
ILE A 413
None
0.53A 3czhA-2iutA:
undetectable
3czhA-2iutA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 LEU A 269
GLU A 305
ILE A 302
None
0.56A 3czhA-2j4dA:
undetectable
3czhA-2j4dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4n PROTEIN AFD-1,
ISOFORM A


(Caenorhabditis
elegans)
PF00788
(RA)
3 LEU A   7
GLU A  26
ILE A  27
None
0.60A 3czhA-2m4nA:
undetectable
3czhA-2m4nA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 LEU A 143
GLU A 130
ILE A 127
None
0.55A 3czhA-2pwzA:
undetectable
3czhA-2pwzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkb RIBONUCLEASE H1

(Homo sapiens)
PF00075
(RNase_H)
3 LEU A 176
GLU A 186
ILE A 187
None
A  C  11 ( 3.9A)
None
0.59A 3czhA-2qkbA:
undetectable
3czhA-2qkbA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE


(Escherichia
coli)
PF01266
(DAO)
3 LEU A 207
GLU A 185
ILE A 184
FAD  A1373 (-3.9A)
None
None
0.51A 3czhA-2uzzA:
undetectable
3czhA-2uzzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2


(Homo sapiens)
PF00709
(Adenylsucc_synt)
3 LEU A 405
GLU A 435
ILE A 432
None
0.60A 3czhA-2v40A:
undetectable
3czhA-2v40A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
3 LEU A 223
GLU A 250
ILE A 247
None
0.60A 3czhA-2v7gA:
undetectable
3czhA-2v7gA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voa EXODEOXYRIBONUCLEASE
III


(Archaeoglobus
fulgidus)
PF03372
(Exo_endo_phos)
3 LEU A   2
GLU A  72
ILE A  96
None
0.47A 3czhA-2voaA:
undetectable
3czhA-2voaA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvf MAJOR CAPSID PROTEIN
P2


(Pseudoalteromonas
virus PM2)
no annotation 3 LEU A 197
GLU A 160
ILE A 246
None
0.58A 3czhA-2vvfA:
undetectable
3czhA-2vvfA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlb ELECTRON TRANSFER
PROTEIN 1,
MITOCHONDRIAL


(Schizosaccharomyces
pombe)
PF00111
(Fer2)
3 LEU A 606
GLU A 534
ILE A 533
None
0.46A 3czhA-2wlbA:
undetectable
3czhA-2wlbA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvi MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA


(Homo sapiens)
PF08311
(Mad3_BUB1_I)
3 LEU A 189
GLU A 177
ILE A 174
None
0.56A 3czhA-2wviA:
undetectable
3czhA-2wviA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Aquifex
aeolicus)
PF02348
(CTP_transf_3)
3 LEU A 120
GLU A 102
ILE A 104
None
0.60A 3czhA-2y6pA:
undetectable
3czhA-2y6pA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y75 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYMR


(Bacillus
subtilis)
PF02082
(Rrf2)
3 LEU A 121
GLU A  17
ILE A  14
None
0.60A 3czhA-2y75A:
undetectable
3czhA-2y75A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00180
(Iso_dh)
3 LEU B 298
GLU B  28
ILE B  27
None
0.53A 3czhA-3blxB:
undetectable
3czhA-3blxB:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens)
PF00067
(p450)
3 LEU A 257
GLU A 306
ILE A 309
None
VD3  A 701 ( 4.8A)
None
0.12A 3czhA-3c6gA:
65.1
3czhA-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c85 PUTATIVE
GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFB


(Vibrio
parahaemolyticus)
PF02254
(TrkA_N)
3 LEU A 141
GLU A 158
ILE A 155
None
0.54A 3czhA-3c85A:
undetectable
3czhA-3c85A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE


(Desulfovibrio
alaskensis)
no annotation 3 LEU A 384
GLU A 367
ILE A 348
None
0.60A 3czhA-3c8vA:
undetectable
3czhA-3c8vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE


(Bdellovibrio
bacteriovorus)
no annotation 3 LEU A  63
GLU A  73
ILE A  76
None
0.57A 3czhA-3cawA:
undetectable
3czhA-3cawA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE


(Methanosarcina
mazei)
PF01933
(UPF0052)
3 LEU A  26
GLU A  19
ILE A  20
None
0.52A 3czhA-3cgwA:
undetectable
3czhA-3cgwA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima)
PF14505
(DUF4438)
3 LEU A  78
GLU A  16
ILE A 130
None
0.53A 3czhA-3dclA:
undetectable
3czhA-3dclA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE


(Paenibacillus
barcinonensis)
PF00331
(Glyco_hydro_10)
3 LEU A 150
GLU A 137
ILE A 143
None
0.56A 3czhA-3emqA:
undetectable
3czhA-3emqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9q FERRICHROME-BINDING
PROTEIN


(Bacillus
subtilis)
PF01497
(Peripla_BP_2)
3 LEU A 114
GLU A 100
ILE A 102
None
0.60A 3czhA-3g9qA:
undetectable
3czhA-3g9qA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE


(Psychrobacter
arcticus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
3 LEU A 439
GLU A 402
ILE A 401
None
0.54A 3czhA-3hn7A:
undetectable
3czhA-3hn7A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis)
PF00155
(Aminotran_1_2)
3 LEU A 111
GLU A 142
ILE A 143
None
0.56A 3czhA-3jtxA:
undetectable
3czhA-3jtxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae)
no annotation 3 LEU A1021
GLU A 957
ILE A 960
None
0.60A 3czhA-3kfoA:
undetectable
3czhA-3kfoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN


(Bacteroides
thetaiotaomicron)
PF01865
(PhoU_div)
3 LEU A  34
GLU A 192
ILE A 189
None
PO4  A 217 ( 4.9A)
None
0.52A 3czhA-3l39A:
undetectable
3czhA-3l39A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE


(Idiomarina
loihiensis)
PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat)
3 LEU A 168
GLU A 203
ILE A 207
None
0.54A 3czhA-3llxA:
undetectable
3czhA-3llxA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis)
PF09754
(PAC2)
3 LEU A  36
GLU A 210
ILE A 213
None
0.54A 3czhA-3mnfA:
undetectable
3czhA-3mnfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD


(Thermoplasma
acidophilum)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
3 LEU A  94
GLU A  91
ILE A  33
None
0.54A 3czhA-3ngxA:
undetectable
3czhA-3ngxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
3 LEU A 491
GLU A 382
ILE A 381
None
0.57A 3czhA-3opyA:
undetectable
3czhA-3opyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A


(Thermotoga
maritima)
PF00005
(ABC_tran)
3 LEU A 732
GLU A 728
ILE A 727
None
0.48A 3czhA-3pihA:
undetectable
3czhA-3pihA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE


(Alicyclobacillus
acidocaldarius)
PF13393
(tRNA-synt_His)
3 LEU A  44
GLU A 352
ILE A 327
None
0.57A 3czhA-3racA:
undetectable
3czhA-3racA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Coxiella
burnetii)
PF00275
(EPSP_synthase)
3 LEU A 357
GLU A 379
ILE A 405
None
0.58A 3czhA-3tr1A:
undetectable
3czhA-3tr1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Corynebacterium
glutamicum)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 LEU A 225
GLU A 172
ILE A 171
None
0.58A 3czhA-3tx8A:
undetectable
3czhA-3tx8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urg ALR1010 PROTEIN

(Nostoc sp. PCC
7120)
PF11535
(Calci_bind_CcbP)
3 LEU A 117
GLU A 101
ILE A 100
None
0.59A 3czhA-3urgA:
undetectable
3czhA-3urgA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4


(Rattus
norvegicus)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
3 LEU C 597
GLU C 580
ILE C 592
None
0.55A 3czhA-3v64C:
undetectable
3czhA-3v64C:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4


(Rattus
norvegicus)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
3 LEU B 597
GLU B 580
ILE B 592
None
0.48A 3czhA-3v65B:
undetectable
3czhA-3v65B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2)
3 LEU A 129
GLU A 155
ILE A 154
None
0.60A 3czhA-4a2wA:
undetectable
3czhA-4a2wA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica)
PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N)
3 LEU A 322
GLU A 294
ILE A 293
None
0.57A 3czhA-4areA:
undetectable
3czhA-4areA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
3 LEU V1149
GLU V1236
ILE V1183
None
0.57A 3czhA-4bxsV:
undetectable
3czhA-4bxsV:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1


(Saccharomyces
cerevisiae)
PF09770
(PAT1)
3 LEU H 511
GLU H 488
ILE H 489
None
0.59A 3czhA-4c8qH:
undetectable
3czhA-4c8qH:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus)
PF00973
(Paramyxo_ncap)
3 LEU A  92
GLU A  98
ILE A  35
None
0.59A 3czhA-4co6A:
undetectable
3czhA-4co6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 LEU A 143
GLU A 130
ILE A 127
None
0.53A 3czhA-4e0bA:
undetectable
3czhA-4e0bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 LEU B 631
GLU B 602
ILE B 596
None
0.53A 3czhA-4f92B:
undetectable
3czhA-4f92B:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE


(Escherichia
coli;
Escherichia
virus Qbeta)
PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B)
3 LEU A 934
GLU A1026
ILE A1029
None
GTP  A2501 (-2.5A)
None
0.56A 3czhA-4fwtA:
undetectable
3czhA-4fwtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans)
PF00202
(Aminotran_3)
3 LEU A 179
GLU A 212
ILE A 209
None
0.48A 3czhA-4grxA:
undetectable
3czhA-4grxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwf BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
3


(Arabidopsis
thaliana)
PF02179
(BAG)
3 LEU A 171
GLU A 157
ILE A 160
None
0.60A 3czhA-4hwfA:
undetectable
3czhA-4hwfA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli)
PF15935
(RnlA_toxin)
3 LEU A  85
GLU A  20
ILE A  17
None
0.42A 3czhA-4i8oA:
undetectable
3czhA-4i8oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'


(Hevea
brasiliensis)
PF00332
(Glyco_hydro_17)
3 LEU A 139
GLU A  94
ILE A  95
None
0.57A 3czhA-4iisA:
undetectable
3czhA-4iisA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxu PUTATIVE
AMINOTRANSFERASE


(Sinorhizobium
meliloti)
PF01063
(Aminotran_4)
3 LEU A 239
GLU A 236
ILE A 235
None
0.59A 3czhA-4jxuA:
undetectable
3czhA-4jxuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE


(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 LEU A 100
GLU A 330
ILE A 329
None
0.50A 3czhA-4koaA:
undetectable
3czhA-4koaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nng 30S RIBOSOMAL
PROTEIN S1


(Mycobacterium
tuberculosis)
PF00575
(S1)
3 LEU A 360
GLU A 318
ILE A 317
None
0.54A 3czhA-4nngA:
undetectable
3czhA-4nngA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7y METHIONINE
GAMMA-LYASE


(Citrobacter
freundii)
PF01053
(Cys_Met_Meta_PP)
3 LEU A 301
GLU A 169
ILE A 168
None
0.60A 3czhA-4p7yA:
undetectable
3czhA-4p7yA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN


(Aeropyrum
pernix)
PF02608
(Bmp)
3 LEU A 323
GLU A 362
ILE A 364
None
0.56A 3czhA-4pevA:
undetectable
3czhA-4pevA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2


(Mus musculus)
PF00773
(RNB)
PF17216
(Rrp44_CSD1)
3 LEU A 849
GLU A 326
ILE A 327
None
0.60A 3czhA-4pmwA:
undetectable
3czhA-4pmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU


(Pseudomonas
fluorescens)
PF01734
(Patatin)
3 LEU A 117
GLU A 179
ILE A 176
BME  A 700 ( 4.9A)
None
None
0.58A 3czhA-4qmkA:
undetectable
3czhA-4qmkA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa)
no annotation 3 LEU B 158
GLU B  63
ILE B  67
None
0.56A 3czhA-4r0mB:
undetectable
3czhA-4r0mB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Dictyostelium
purpureum)
PF05450
(Nicastrin)
3 LEU A 262
GLU A 342
ILE A 341
None
0.60A 3czhA-4r12A:
undetectable
3czhA-4r12A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2


(Blattella
germanica)
PF00026
(Asp)
3 LEU A 131
GLU A  86
ILE A  85
None
0.54A 3czhA-4rldA:
undetectable
3czhA-4rldA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2x IMPORTIN SUBUNIT
ALPHA-6


(Homo sapiens)
PF00514
(Arm)
PF16186
(Arm_3)
3 LEU D 336
GLU D 358
ILE D 355
None
0.52A 3czhA-4u2xD:
undetectable
3czhA-4u2xD:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
3 LEU A  21
GLU A  12
ILE A   9
None
0.58A 3czhA-4xriA:
undetectable
3czhA-4xriA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE


(Homo sapiens)
PF04389
(Peptidase_M28)
3 LEU A 284
GLU A 277
ILE A 274
None
0.53A 3czhA-4yu9A:
undetectable
3czhA-4yu9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster)
PF01436
(NHL)
3 LEU A1009
GLU A 970
ILE A 971
None
0.60A 3czhA-4zlrA:
undetectable
3czhA-4zlrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE


(Acinetobacter
baumannii)
PF01208
(URO-D)
3 LEU A  14
GLU A 237
ILE A 243
None
0.49A 3czhA-4zr8A:
undetectable
3czhA-4zr8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
3 LEU A 276
GLU A 869
ILE A 866
None
0.59A 3czhA-5bqnA:
undetectable
3czhA-5bqnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2


(Arabidopsis
thaliana)
PF16953
(PRORP)
PF17177
(PPR_long)
3 LEU A 308
GLU A 448
ILE A 446
None
0.55A 3czhA-5dizA:
undetectable
3czhA-5dizA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE


(Colwellia
psychrerythraea)
PF01048
(PNP_UDP_1)
3 LEU A  38
GLU A  18
ILE A  15
None
0.56A 3czhA-5dk6A:
undetectable
3czhA-5dk6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej0 ENVELOPE PROTEIN H3

(Vaccinia virus)
PF03213
(Pox_P35)
3 LEU A 208
GLU A 201
ILE A 198
None
0.55A 3czhA-5ej0A:
undetectable
3czhA-5ej0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1


(Hyoscyamus
muticus)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 LEU A 158
GLU A 174
ILE A 171
None
0.54A 3czhA-5jo7A:
undetectable
3czhA-5jo7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2)
PF13614
(AAA_31)
3 LEU A 161
GLU A 306
ILE A 303
None
0.56A 3czhA-5k5zA:
undetectable
3czhA-5k5zA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00567
(TUDOR)
3 LEU A 666
GLU A 621
ILE A 623
None
0.59A 3czhA-5m9nA:
undetectable
3czhA-5m9nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 LEU A 753
GLU A 760
ILE A 761
None
0.58A 3czhA-5ujaA:
undetectable
3czhA-5ujaA:
16.08