SIMILAR PATTERNS OF AMINO ACIDS FOR 3CZH_A_D2VA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB

(Klebsiella
aerogenes) 		PF03466
(LysR_substrate) 		5 VAL A  97
ALA A 143
VAL A 122
ILE A 272
THR A  99
 None
 1.09A 3czhA-1al3A:
0.0		 3czhA-1al3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 THR A 580
PHE A 535
ALA A 479
ALA A 570
VAL A 568
 None
None
NA  A 996 (-3.0A)
CL  A 995 ( 4.9A)
None
 1.14A 3czhA-1ck7A:
undetectable		 3czhA-1ck7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ALA A  84
ALA A 114
THR A   8
VAL A  10
ILE A  93
 None
 1.05A 3czhA-1cqjA:
0.0		 3czhA-1cqjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 THR A 142
VAL A  76
VAL A  40
ILE A 162
THR A  46
 None
 1.09A 3czhA-1e5dA:
0.0		 3czhA-1e5dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		6 ALA A 576
ALA A 147
VAL A 175
VAL A  51
ILE A  29
THR A  44
 None
 1.49A 3czhA-1gpeA:
0.0		 3czhA-1gpeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A   5
VAL A  58
VAL A 117
ILE A 115
THR A  76
 None
None
NAD  A1306 (-4.2A)
None
None
 1.09A 3czhA-1guzA:
0.0		 3czhA-1guzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 VAL A  82
THR A 116
VAL A 195
ILE A 197
THR A 127
 None
 1.08A 3czhA-1h79A:
0.0		 3czhA-1h79A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 159
ALA A 153
ALA A 197
VAL A 338
ILE A 141
 None
 1.10A 3czhA-1khdA:
0.0		 3czhA-1khdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mww HYPOTHETICAL PROTEIN
HI1388.1

(Haemophilus
influenzae) 		PF14552
(Tautomerase_2) 		5 VAL A   4
ALA A  38
VAL A  97
ILE A  99
THR A  60
 None
 0.90A 3czhA-1mwwA:
undetectable		 3czhA-1mwwA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 THR A 214
ASN A 256
ALA A 145
ALA A 201
ILE A 150
 None
 1.04A 3czhA-1rrmA:
undetectable		 3czhA-1rrmA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 135
VAL A  31
VAL A 146
ILE A 142
THR A 147
 None
NAD  A 401 (-3.7A)
None
None
None
 1.13A 3czhA-1t2fA:
undetectable		 3czhA-1t2fA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 THR A 324
ALA A 317
VAL A  53
THR A 186
ILE A 289
 None
 1.11A 3czhA-1un9A:
undetectable		 3czhA-1un9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 THR A 135
VAL A  67
VAL A 125
ILE A 127
THR A  41
 GTP  A 500 (-3.6A)
None
None
None
None
 1.14A 3czhA-1w5eA:
undetectable		 3czhA-1w5eA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		5 VAL A 179
ALA A 190
ALA A 162
VAL A 165
MET A 288
 None
 1.11A 3czhA-1x9jA:
undetectable		 3czhA-1x9jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ASN A  77
VAL A  24
ALA A  28
ALA A 626
THR A  17
 None
 1.08A 3czhA-2b0tA:
undetectable		 3czhA-2b0tA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		5 VAL A 312
ALA A 193
VAL A 307
ILE A 304
THR A 308
 None
 1.12A 3czhA-2c5sA:
undetectable		 3czhA-2c5sA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASN A 275
VAL A  75
ALA A 224
VAL A  58
THR A  59
 XMP  A1001 ( 4.4A)
None
None
None
None
 1.10A 3czhA-2cu0A:
undetectable		 3czhA-2cu0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh7 NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		5 THR A 170
PHE A 120
ALA A 126
ALA A 151
ILE A 108
 None
 1.04A 3czhA-2dh7A:
undetectable		 3czhA-2dh7A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 VAL A 166
ALA A 170
VAL A 120
VAL A 193
ILE A 203
 None
 1.00A 3czhA-2e7jA:
undetectable		 3czhA-2e7jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 VAL A 546
ALA A 548
ALA A 555
ILE A 607
THR A 636
 None
 1.12A 3czhA-2g5tA:
undetectable		 3czhA-2g5tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04268
(SoxG) 		5 THR C 168
ALA C 153
THR C 182
VAL C 186
THR C 185
 None
 1.03A 3czhA-2gahC:
undetectable		 3czhA-2gahC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 THR A 441
VAL A 356
ALA A 392
VAL A 378
THR A 359
 None
 1.08A 3czhA-2glfA:
undetectable		 3czhA-2glfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		5 VAL A   7
ALA A  46
VAL A 223
ILE A   3
THR A 203
 None
 1.12A 3czhA-2gzxA:
undetectable		 3czhA-2gzxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		5 VAL A 403
ALA A 406
ALA A  85
VAL A 132
ILE A 102
 None
 1.13A 3czhA-2higA:
undetectable		 3czhA-2higA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 PHE B 427
ALA B 313
ALA B 424
VAL B 423
ILE B 439
 None
 0.91A 3czhA-2pffB:
undetectable		 3czhA-2pffB:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		5 VAL A 120
ALA A 121
ALA A  91
THR A 277
VAL A 350
 None
 1.05A 3czhA-2r7dA:
undetectable		 3czhA-2r7dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		5 THR A 158
VAL A  93
ALA A 122
VAL A 201
ILE A 197
 None
 1.13A 3czhA-2rckA:
undetectable		 3czhA-2rckA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 THR G 314
VAL G 395
ALA G 308
VAL G 358
THR G 357
 None
 0.96A 3czhA-2vdcG:
undetectable		 3czhA-2vdcG:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 THR A  98
ALA A  72
ALA A  81
VAL A  84
THR A 232
 None
 1.15A 3czhA-2vosA:
undetectable		 3czhA-2vosA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 193
ALA A 191
ALA A 254
VAL A  84
ILE A  71
 None
 1.04A 3czhA-2vosA:
undetectable		 3czhA-2vosA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR B 527
VAL B 540
ALA B 469
VAL B 511
ILE B 513
 XAX  B1778 ( 4.9A)
None
None
None
None
 0.98A 3czhA-2w55B:
undetectable		 3czhA-2w55B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A 365
VAL A 426
ALA A 429
ALA A 343
VAL A 342
 None
 1.12A 3czhA-2yfhA:
undetectable		 3czhA-2yfhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 VAL A  10
ALA A 155
THR A  38
VAL A  16
THR A  14
 None
 1.02A 3czhA-2yv2A:
undetectable		 3czhA-2yv2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 THR A  15
VAL A 100
ALA A 213
VAL A  97
MET A  99
 None
 1.15A 3czhA-2zskA:
undetectable		 3czhA-2zskA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 VAL A 728
ALA A 726
VAL A 632
ILE A 748
MET A 743
 None
 1.14A 3czhA-3a0fA:
undetectable		 3czhA-3a0fA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 PHE A 103
VAL A 130
ALA A  74
VAL A  61
ILE A  86
 None
 1.10A 3czhA-3a74A:
undetectable		 3czhA-3a74A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ad9 SARCOSINE OXIDASE
GAMMA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04268
(SoxG) 		5 THR C 166
ALA C 151
THR C 180
VAL C 184
THR C 183
 None
 1.05A 3czhA-3ad9C:
undetectable		 3czhA-3ad9C:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		6 ALA A 222
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 1.32A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		7 THR A 119
ASN A 126
PHE A 214
ALA A 250
VAL A 253
THR A 488
ILE A 379
 None
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.2A)
VD3  A 701 ( 4.6A)
HEM  A 601 ( 4.1A)
 1.48A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		12 THR A 119
ASN A 126
PHE A 214
VAL A 218
ALA A 221
ALA A 250
VAL A 253
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.17A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 VAL A 369
ALA A 370
VAL A 362
ILE A  23
THR A 365
 None
 1.04A 3czhA-3cwcA:
undetectable		 3czhA-3cwcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 163
ALA A 805
VAL A 651
ILE A 167
THR A 683
 None
 1.14A 3czhA-3ddrA:
undetectable		 3czhA-3ddrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A 439
ALA A 441
ALA A 250
VAL A  33
ILE A  20
 None
 1.03A 3czhA-3ifrA:
undetectable		 3czhA-3ifrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		5 VAL A 133
ALA A 157
ALA A 143
VAL A 142
THR A 212
 NAD  A 377 (-4.7A)
None
None
None
None
 1.14A 3czhA-3jyoA:
undetectable		 3czhA-3jyoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 ASN A 284
ALA A 161
ALA A  91
THR A 182
THR A 154
 None
 1.14A 3czhA-3k2wA:
undetectable		 3czhA-3k2wA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 PHE A 173
VAL A 134
ALA A  85
VAL A 171
THR A 136
 None
 1.10A 3czhA-3l77A:
undetectable		 3czhA-3l77A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		5 ALA A 349
VAL A  36
THR A  93
VAL A 109
MET A 328
 None
 1.06A 3czhA-3lreA:
undetectable		 3czhA-3lreA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		5 PHE A 245
VAL A 358
ALA A 282
VAL A 218
ILE A 401
 PO4  A  11 ( 4.9A)
PO4  A  11 (-4.1A)
GOL  A 426 ( 4.8A)
None
None
 1.13A 3czhA-3maeA:
undetectable		 3czhA-3maeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 240
ALA A 177
ALA A 303
VAL A 224
ILE A 209
 FEF  A 668 ( 4.3A)
None
FEF  A 668 ( 4.0A)
FEF  A 668 (-4.7A)
None
 1.13A 3czhA-3mtlA:
undetectable		 3czhA-3mtlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 332
ALA A 335
ALA A 406
VAL A 206
ILE A 370
 None
 1.15A 3czhA-3n5fA:
undetectable		 3czhA-3n5fA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 PHE A 147
VAL A 237
ALA A 280
VAL A 243
THR A 235
 None
 1.06A 3czhA-3nipA:
undetectable		 3czhA-3nipA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		5 VAL A 196
ALA A 214
VAL A  57
ILE A  59
THR A 170
 None
 1.03A 3czhA-3nxsA:
undetectable		 3czhA-3nxsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor) 		PF00079
(Serpin) 		5 VAL A  28
ALA A  27
ALA A  89
VAL A  35
THR A  32
 None
 1.01A 3czhA-3ozqA:
undetectable		 3czhA-3ozqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		6 VAL A 247
ALA A 249
ALA A 288
VAL A 290
VAL A   7
THR A 261
 None
 1.45A 3czhA-3rmjA:
undetectable		 3czhA-3rmjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		5 ASN A 191
VAL A 135
ALA A 133
THR A 115
THR A 118
 None
 1.01A 3czhA-3s5nA:
undetectable		 3czhA-3s5nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siv NHP2-LIKE PROTEIN 1

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		5 ALA A  39
ALA A  57
VAL A  83
THR A 105
THR A  45
 U  F  36 ( 3.1A)
None
None
None
None
 1.07A 3czhA-3sivA:
undetectable		 3czhA-3sivA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 282
VAL A 269
THR A 174
VAL A 178
THR A 295
 None
 0.97A 3czhA-3tbhA:
undetectable		 3czhA-3tbhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 THR A 148
ALA A 157
THR A 131
VAL A 161
MET A 159
 None
 0.97A 3czhA-3ti8A:
undetectable		 3czhA-3ti8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		5 ALA A 116
VAL A 118
VAL A  43
ILE A  45
MET A  65
 None
 1.10A 3czhA-3tisA:
undetectable		 3czhA-3tisA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		5 PHE A 315
ALA A 322
ALA A 275
VAL A 277
ILE A 177
 None
 1.15A 3czhA-3ty4A:
undetectable		 3czhA-3ty4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		6 PHE A 826
VAL A 846
ALA A 763
VAL A 828
ILE A 770
THR A 848
 None
 1.43A 3czhA-3ubhA:
undetectable		 3czhA-3ubhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A 477
ALA A 475
VAL A 513
VAL A 430
ILE A 432
 None
 1.03A 3czhA-3vueA:
undetectable		 3czhA-3vueA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		5 THR A  11
PHE A 129
ALA A  94
ALA A 117
THR A 122
 None
 0.94A 3czhA-3wvaA:
undetectable		 3czhA-3wvaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.12A 3czhA-4a11B:
undetectable		 3czhA-4a11B:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 PHE A 360
THR A 298
ILE A 427
MET A 334
THR A 333
 None
 1.11A 3czhA-4aeeA:
undetectable		 3czhA-4aeeA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		5 THR A 247
PHE A 205
VAL A 214
ALA A 208
THR A 185
 None
None
None
None
NAP  A1250 (-2.6A)
 1.12A 3czhA-4bmsA:
undetectable		 3czhA-4bmsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 THR A  97
PHE A  59
VAL A  18
ALA A 100
VAL A 101
 None
 1.03A 3czhA-4di1A:
undetectable		 3czhA-4di1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A  27
ALA A  26
VAL A  34
ILE A  53
THR A  31
 None
 1.04A 3czhA-4e1lA:
undetectable		 3czhA-4e1lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ASN A  87
ALA A 148
VAL A 150
ILE A  83
THR A 106
 None
 1.11A 3czhA-4eqyA:
undetectable		 3czhA-4eqyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 225
ALA A 147
ALA A 218
ILE A 186
THR A 176
 None
 1.14A 3czhA-4eyeA:
undetectable		 3czhA-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 VAL A 137
ALA A 140
VAL A 103
THR A 188
ILE A 127
 None
None
PG4  A 504 ( 4.7A)
None
None
 1.03A 3czhA-4f0sA:
undetectable		 3czhA-4f0sA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		no annotation 5 ALA B1719
VAL B1807
ILE B1709
MET B1803
THR B1804
 None
 1.13A 3czhA-4f7gB:
undetectable		 3czhA-4f7gB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 VAL A 193
ALA A 196
VAL A 178
THR A 214
ILE A 223
 None
None
None
CA  A 604 (-3.2A)
None
 1.10A 3czhA-4gvlA:
undetectable		 3czhA-4gvlA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		5 VAL A 193
ALA A 196
VAL A 178
THR A 214
ILE A 223
 None
 1.10A 3czhA-4gx0A:
undetectable		 3czhA-4gx0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 ALA A 262
ALA A 266
VAL A 267
ILE A 213
THR A 239
 None
CL  A 507 ( 3.9A)
None
None
None
 1.08A 3czhA-4hw6A:
undetectable		 3czhA-4hw6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmn PROBABLE
L,D-TRANSPEPTIDASE
LDTA

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 VAL A 200
ALA A 166
VAL A 173
THR A 159
VAL A 249
 None
 1.05A 3czhA-4jmnA:
undetectable		 3czhA-4jmnA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		6 PHE A 297
VAL A 135
THR A 283
VAL A  95
ILE A 276
THR A 119
 None
 1.26A 3czhA-4joqA:
undetectable		 3czhA-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		6 VAL A 135
ALA A 136
THR A 283
VAL A  95
ILE A 276
THR A 119
 None
 1.23A 3czhA-4joqA:
undetectable		 3czhA-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 240
ALA A 239
ALA A 232
ILE A 186
THR A 244
 None
 1.14A 3czhA-4l69A:
undetectable		 3czhA-4l69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 THR A 347
VAL A 228
VAL A 293
ILE A 255
THR A 236
 None
 1.15A 3czhA-4lbwA:
undetectable		 3czhA-4lbwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASN A 432
VAL A 199
VAL A 405
MET A 202
THR A 203
 None
 1.14A 3czhA-4mqtA:
undetectable		 3czhA-4mqtA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		5 VAL A 226
VAL A 193
VAL A 208
ILE A 132
THR A 207
 None
 0.97A 3czhA-4o6vA:
undetectable		 3czhA-4o6vA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		5 ALA A 281
ALA A  60
VAL A  65
VAL A 130
ILE A  96
 None
 1.09A 3czhA-4ry8A:
undetectable		 3czhA-4ry8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 VAL A 427
ALA A 430
ALA A 392
VAL A 397
THR A 358
 None
 1.13A 3czhA-4w1wA:
undetectable		 3czhA-4w1wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		5 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.12A 3czhA-4xz7A:
undetectable		 3czhA-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 336
ALA A 335
ALA A 328
MET A 339
THR A 340
 None
 1.09A 3czhA-5fjiA:
undetectable		 3czhA-5fjiA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		5 ALA A 224
ALA A 202
VAL A 138
ILE A 136
THR A 237
 None
 1.08A 3czhA-5fl3A:
undetectable		 3czhA-5fl3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 THR A  81
ALA A  77
THR A 164
VAL A  24
ILE A  22
 None
 1.01A 3czhA-5habA:
undetectable		 3czhA-5habA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A 365
VAL A 426
ALA A 429
ALA A 343
VAL A 342
 None
 1.12A 3czhA-5ijzA:
undetectable		 3czhA-5ijzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixx ALR2278 PROTEIN

(Nostoc sp. PCC
7120) 		PF07700
(HNOB) 		5 VAL A   5
ALA A   8
VAL A 108
VAL A  52
THR A  48
 6EX  A 202 (-4.0A)
None
HEM  A 201 ( 4.7A)
None
None
 1.13A 3czhA-5ixxA:
undetectable		 3czhA-5ixxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 THR A  78
VAL A 169
ALA A 190
THR A 246
VAL A 289
 None
TES  A 502 ( 4.4A)
None
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 1.12A 3czhA-5l94A:
33.6		 3czhA-5l94A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 PHE A  10
VAL A  27
ALA A  93
VAL A   8
ILE A  54
 None
 1.04A 3czhA-5m2oA:
undetectable		 3czhA-5m2oA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 THR A  84
VAL A  88
VAL A 121
ILE A 124
THR A 148
 None
 1.09A 3czhA-5mzsA:
undetectable		 3czhA-5mzsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ALA A 171
ALA A 146
VAL A 144
THR A 161
ILE A 155
 None
 1.01A 3czhA-5ujsA:
undetectable		 3czhA-5ujsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 VAL A 221
ALA A 213
VAL A 276
ILE A 278
THR A 261
 None
 0.86A 3czhA-5w19A:
undetectable		 3czhA-5w19A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 VAL A 221
ALA A 257
VAL A 276
ILE A 278
THR A 261
 None
 0.84A 3czhA-5w19A:
undetectable		 3czhA-5w19A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 THR B 571
VAL B 575
VAL B 606
ILE B 608
THR B 621
 None
 1.12A 3czhA-5xogB:
undetectable		 3czhA-5xogB:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 VAL 2 654
ALA 2 658
VAL 2 551
VAL 2 633
ILE 2 414
 None
 1.11A 3czhA-5zvs2:
undetectable		 3czhA-5zvs2:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 VAL D 457
ALA D 461
ALA D 479
THR D 453
ILE D 468
 None
 1.15A 3czhA-6f5dD:
undetectable		 3czhA-6f5dD:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 VAL A1006
ALA A1005
VAL A1201
VAL A1022
ILE A1152
 None
 1.14A 3czhA-6fikA:
undetectable		 3czhA-6fikA:
10.54