SIMILAR PATTERNS OF AMINO ACIDS FOR 3CYX_A_ROCA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		3 ARG A 385
VAL A 452
THR A 462
 None
 0.77A 3cyxA-1e0tA:
0.0		 3cyxA-1e0tA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		3 ARG A 147
VAL A 134
THR A  96
 None
 0.71A 3cyxA-1hvyA:
0.0		 3cyxA-1hvyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A 412
VAL A 366
THR A 373
 None
 0.79A 3cyxA-1i41A:
undetectable		 3cyxA-1i41A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msb MANNOSE-BINDING
PROTEIN-A

(Rattus rattus) 		PF00059
(Lectin_C) 		3 ARG A 118
VAL A 150
THR A 114
 None
 0.72A 3cyxA-1msbA:
undetectable		 3cyxA-1msbA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ARG A  81
VAL A 293
THR A  96
 None
 0.66A 3cyxA-1o99A:
0.0		 3cyxA-1o99A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 ARG A 277
VAL A  84
THR A  47
 None
 0.84A 3cyxA-1qpoA:
0.0		 3cyxA-1qpoA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		3 ARG A  47
VAL A  61
THR A  38
 None
 0.75A 3cyxA-1ralA:
0.0		 3cyxA-1ralA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 ARG A 725
VAL A 659
THR A 687
 None
 0.84A 3cyxA-1sy7A:
0.0		 3cyxA-1sy7A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		3 ARG A 141
VAL A 131
THR A  26
 None
 0.75A 3cyxA-1tqhA:
0.0		 3cyxA-1tqhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysm CALCYCLIN-BINDING
PROTEIN

(Mus musculus) 		PF09032
(Siah-Interact_N) 		3 ARG A  24
VAL A  15
THR A  30
 None
 0.79A 3cyxA-1ysmA:
undetectable		 3cyxA-1ysmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		3 ARG A 124
VAL A  94
THR A 117
 None
 0.84A 3cyxA-2eguA:
undetectable		 3cyxA-2eguA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3

(Branchiostoma
floridae) 		PF07686
(V-set) 		3 ARG J 106
VAL J 131
THR J 135
 None
 0.76A 3cyxA-2fboJ:
undetectable		 3cyxA-2fboJ:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ARG A  78
VAL A  99
THR A   6
 None
 0.71A 3cyxA-2gcaA:
undetectable		 3cyxA-2gcaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gli PROTEIN (FIVE-FINGER
GLI)

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 ARG A 183
VAL A 122
THR A 165
 None
 0.78A 3cyxA-2gliA:
undetectable		 3cyxA-2gliA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		3 ARG A 252
VAL A 215
THR A 223
 None
 0.72A 3cyxA-2gszA:
undetectable		 3cyxA-2gszA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ARG B 123
VAL B 132
THR B 167
 None
 0.74A 3cyxA-2hdnB:
undetectable		 3cyxA-2hdnB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijc HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF02627
(CMD) 		3 ARG A 135
VAL A  38
THR A  92
 None
 0.85A 3cyxA-2ijcA:
undetectable		 3cyxA-2ijcA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgq HOMEOBOX PROTEIN
CEH-37

(Caenorhabditis
elegans) 		PF00046
(Homeobox) 		3 ARG A  14
VAL A  38
THR A  22
 None
 0.70A 3cyxA-2mgqA:
undetectable		 3cyxA-2mgqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4d HYPOTHETICAL PROTEIN
PA0269

(Pseudomonas
aeruginosa) 		PF02627
(CMD) 		3 ARG A 135
VAL A  38
THR A  92
 None
 0.83A 3cyxA-2o4dA:
undetectable		 3cyxA-2o4dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ARG A  82
VAL A  88
THR A  95
 GOL  A1497 (-4.5A)
None
None
 0.58A 3cyxA-2vosA:
undetectable		 3cyxA-2vosA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF05362
(Lon_C) 		3 ARG A 871
VAL A 764
THR A 760
 None
 0.87A 3cyxA-2x36A:
undetectable		 3cyxA-2x36A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		3 ARG A 222
VAL A 101
THR A 110
 None
 0.86A 3cyxA-2xhcA:
undetectable		 3cyxA-2xhcA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 ARG A 158
VAL A 284
THR A 287
 None
 0.72A 3cyxA-2xymA:
undetectable		 3cyxA-2xymA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 ARG A  14
VAL A  90
THR A 171
 FMT  A1264 (-4.0A)
None
None
 0.85A 3cyxA-2yn2A:
undetectable		 3cyxA-2yn2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z99 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF04079
(SMC_ScpB) 		3 ARG A 150
VAL A 140
THR A 117
 None
 0.79A 3cyxA-2z99A:
undetectable		 3cyxA-2z99A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 ARG A 663
VAL A 641
THR A 668
 None
 0.80A 3cyxA-3aqpA:
undetectable		 3cyxA-3aqpA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 544
VAL A  53
THR A 118
 None
 0.74A 3cyxA-3b96A:
undetectable		 3cyxA-3b96A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		3 ARG A 701
VAL A 645
THR A 675
 None
 0.83A 3cyxA-3e1sA:
undetectable		 3cyxA-3e1sA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb6 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		3 ARG A 555
VAL A 568
THR A 601
 None
 0.87A 3cyxA-3eb6A:
undetectable		 3cyxA-3eb6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f00 SYNAPTOTAGMIN-1

(Homo sapiens) 		PF00168
(C2) 		3 ARG A 199
VAL A 181
THR A 195
 SO4  A 268 (-3.8A)
None
None
 0.86A 3cyxA-3f00A:
undetectable		 3cyxA-3f00A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 ARG A 158
VAL A 284
THR A 287
 None
 0.68A 3cyxA-3gszA:
undetectable		 3cyxA-3gszA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Methanocaldococcus
jannaschii) 		PF06026
(Rib_5-P_isom_A) 		3 ARG A 161
VAL A 202
THR A 104
 None
 0.79A 3cyxA-3ixqA:
undetectable		 3cyxA-3ixqA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 3 ARG A 285
VAL A 483
THR A 469
 None
 0.79A 3cyxA-3j26A:
undetectable		 3cyxA-3j26A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ARG A 471
VAL A 572
THR A 558
 None
 0.59A 3cyxA-3mosA:
undetectable		 3cyxA-3mosA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no5 UNCHARACTERIZED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		3 ARG A 215
VAL A 247
THR A 226
 None
 0.83A 3cyxA-3no5A:
undetectable		 3cyxA-3no5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		3 ARG A 245
VAL A 291
THR A 267
 None
 0.81A 3cyxA-3orwA:
undetectable		 3cyxA-3orwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		3 ARG A 235
VAL A 239
THR A 171
 None
 0.83A 3cyxA-3pxgA:
undetectable		 3cyxA-3pxgA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 235
VAL A 239
THR A 171
 None
 0.83A 3cyxA-3pxiA:
undetectable		 3cyxA-3pxiA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		3 ARG A 168
VAL A 154
THR A 114
 None
 0.75A 3cyxA-3qp9A:
undetectable		 3cyxA-3qp9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 148
VAL A 153
THR A 159
 UNX  A 408 ( 4.2A)
None
None
 0.86A 3cyxA-3thuA:
undetectable		 3cyxA-3thuA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnx PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 ARG A 218
VAL A 182
THR A 214
 None
 0.85A 3cyxA-3tnxA:
undetectable		 3cyxA-3tnxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 472
VAL A 460
THR A 465
 None
 0.74A 3cyxA-3u9sA:
undetectable		 3cyxA-3u9sA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 ARG A 593
VAL A 578
THR A 573
 None
 0.85A 3cyxA-3v9fA:
undetectable		 3cyxA-3v9fA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 148
VAL A 153
THR A 159
 CO3  A 503 (-3.9A)
None
None
 0.85A 3cyxA-3vcnA:
undetectable		 3cyxA-3vcnA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		3 ARG B  84
VAL B  73
THR B 106
 None
 0.82A 3cyxA-3vysB:
undetectable		 3cyxA-3vysB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		3 ARG A 132
VAL A 105
THR A 124
 None
EDO  A1377 (-3.8A)
EDO  A1377 (-3.1A)
 0.81A 3cyxA-4aukA:
undetectable		 3cyxA-4aukA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auq BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		3 ARG B 250
VAL B 263
THR B 295
 None
 0.65A 3cyxA-4auqB:
undetectable		 3cyxA-4auqB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		3 ARG A 361
VAL A   4
THR A 376
 None
 0.78A 3cyxA-4dnhA:
undetectable		 3cyxA-4dnhA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		3 ARG A  13
VAL A  58
THR A 194
 None
 0.65A 3cyxA-4f62A:
undetectable		 3cyxA-4f62A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		3 ARG B 161
VAL B 173
THR B 168
 None
 0.67A 3cyxA-4fhrB:
undetectable		 3cyxA-4fhrB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02536
(mTERF) 		3 ARG B 162
VAL B 222
THR B 197
 SO4  B 401 ( 4.7A)
None
None
 0.66A 3cyxA-4fp9B:
undetectable		 3cyxA-4fp9B:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ARG A 640
VAL A 554
THR A 556
 None
 0.83A 3cyxA-4fysA:
undetectable		 3cyxA-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02536
(mTERF) 		3 ARG B 162
VAL B 222
THR B 197
 None
 0.54A 3cyxA-4fzvB:
undetectable		 3cyxA-4fzvB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN
MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 ARG A  93
VAL B 290
THR B 249
 None
 0.87A 3cyxA-4g56A:
undetectable		 3cyxA-4g56A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Paraburkholderia
xenovorans;
Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 344
VAL A 322
THR A 309
 None
 0.82A 3cyxA-4gxrA:
undetectable		 3cyxA-4gxrA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huq UNCHARACTERIZED
PROTEIN

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		3 ARG S 141
VAL S 111
THR S 149
 None
 0.77A 3cyxA-4huqS:
undetectable		 3cyxA-4huqS:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		3 ARG A  67
VAL A 423
THR A 420
 None
 0.85A 3cyxA-4il3A:
undetectable		 3cyxA-4il3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		3 ARG A 163
VAL A 199
THR A 107
 None
 0.85A 3cyxA-4io1A:
undetectable		 3cyxA-4io1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 ARG A 532
VAL A 565
THR A 557
 None
 0.87A 3cyxA-4jeuA:
undetectable		 3cyxA-4jeuA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE

(Streptococcus
pyogenes) 		PF07461
(NADase_NGA) 		3 ARG A 295
VAL A 280
THR A 275
 None
 0.86A 3cyxA-4kt6A:
undetectable		 3cyxA-4kt6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		3 ARG A 215
VAL A 201
THR A 161
 None
 0.72A 3cyxA-4l4xA:
undetectable		 3cyxA-4l4xA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		3 ARG A 385
VAL A 290
THR A 222
 None
 0.82A 3cyxA-4mh1A:
undetectable		 3cyxA-4mh1A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Brucella suis) 		PF13561
(adh_short_C2) 		3 ARG A 213
VAL A 221
THR A  21
 None
 0.78A 3cyxA-4ni5A:
undetectable		 3cyxA-4ni5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		3 ARG A 234
VAL A 204
THR A 200
 None
 0.80A 3cyxA-4noxA:
undetectable		 3cyxA-4noxA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ARG A  62
VAL A  53
THR A 153
 None
 0.73A 3cyxA-4o4xA:
undetectable		 3cyxA-4o4xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 100
VAL A 302
THR A 312
 None
 0.29A 3cyxA-4o5mA:
undetectable		 3cyxA-4o5mA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		3 ARG A  33
VAL A 181
THR A  62
 None
 0.86A 3cyxA-4oxiA:
undetectable		 3cyxA-4oxiA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		3 ARG A 274
VAL A 206
THR A 263
 None
 0.85A 3cyxA-4p2lA:
undetectable		 3cyxA-4p2lA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG K 212
VAL K 202
THR K 274
 None
 0.87A 3cyxA-4q66K:
undetectable		 3cyxA-4q66K:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		3 ARG A 402
VAL A 222
THR A 114
 None
 0.73A 3cyxA-4r1zA:
undetectable		 3cyxA-4r1zA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9a LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		3 ARG A  97
VAL A  11
THR A  46
 None
 0.63A 3cyxA-4z9aA:
undetectable		 3cyxA-4z9aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		3 ARG A  88
VAL A 164
THR A 110
 EDO  A1572 (-2.7A)
None
None
 0.72A 3cyxA-5a29A:
undetectable		 3cyxA-5a29A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		3 ARG B 190
VAL B 202
THR B 200
 None
 0.84A 3cyxA-5aa4B:
undetectable		 3cyxA-5aa4B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		3 ARG A 217
VAL A 248
THR A 213
 None
 0.44A 3cyxA-5bn7A:
undetectable		 3cyxA-5bn7A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		3 ARG A 113
VAL A 104
THR A 102
 None
 0.76A 3cyxA-5ftzA:
undetectable		 3cyxA-5ftzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		3 ARG C  92
VAL C 331
THR C 345
 None
 0.73A 3cyxA-5g52C:
undetectable		 3cyxA-5g52C:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 3 ARG G 483
VAL G 350
THR G 501
 None
 0.68A 3cyxA-5h0rG:
undetectable		 3cyxA-5h0rG:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ARG A 680
VAL A 684
THR A 582
 None
 0.76A 3cyxA-5i2tA:
undetectable		 3cyxA-5i2tA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		3 ARG A 387
VAL A 377
THR A 284
 None
 0.71A 3cyxA-5jwfA:
undetectable		 3cyxA-5jwfA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		3 ARG A 386
VAL A 376
THR A 283
 None
 0.58A 3cyxA-5jxkA:
undetectable		 3cyxA-5jxkA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40)
PF00443
(UCH) 		3 ARG A 277
VAL C  48
THR C 537
 None
 0.65A 3cyxA-5k1cA:
undetectable		 3cyxA-5k1cA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 ARG A 364
VAL A 369
THR A 335
 None
 0.79A 3cyxA-5lp4A:
undetectable		 3cyxA-5lp4A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 ARG T1618
VAL T1628
THR T1675
 None
 0.82A 3cyxA-5ojsT:
undetectable		 3cyxA-5ojsT:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		3 ARG A 376
VAL A 366
THR A 353
 None
 0.71A 3cyxA-5tj7A:
undetectable		 3cyxA-5tj7A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 ARG A 217
VAL A 258
THR A 261
 None
 0.70A 3cyxA-5tr7A:
undetectable		 3cyxA-5tr7A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		3 ARG A 424
VAL A 130
THR A 442
 None
 0.77A 3cyxA-5u2nA:
undetectable		 3cyxA-5u2nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfe SYNAPTOTAGMIN-1

(Mus musculus) 		no annotation 3 ARG A 199
VAL A 181
THR A 195
 None
 0.87A 3cyxA-5vfeA:
undetectable		 3cyxA-5vfeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 ARG A 322
VAL A 274
THR A 267
 ACT  A 604 (-3.9A)
None
None
 0.77A 3cyxA-5wm4A:
undetectable		 3cyxA-5wm4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5v GD

(Suid
alphaherpesvirus
1) 		PF01537
(Herpes_glycop_D) 		3 ARG A 166
VAL A  69
THR A  59
 None
 0.68A 3cyxA-5x5vA:
undetectable		 3cyxA-5x5vA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		3 ARG A 146
VAL A 222
THR A 184
 None
 0.70A 3cyxA-5xb0A:
undetectable		 3cyxA-5xb0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 3 ARG A 379
VAL A 416
THR A  92
 None
 0.76A 3cyxA-5xmjA:
undetectable		 3cyxA-5xmjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 286
VAL A  70
THR A 210
 None
 0.75A 3cyxA-5xnwA:
undetectable		 3cyxA-5xnwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES4

(Toxoplasma
gondii) 		PF00467
(KOW)
PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		3 ARG E 245
VAL E 225
THR E 220
 U  2 788 ( 4.2A)
None
G  2 750 ( 4.0A)
 0.39A 3cyxA-5xxuE:
undetectable		 3cyxA-5xxuE:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4

(Trichomonas
vaginalis) 		PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		3 ARG E 245
VAL E 225
THR E 220
 U  2 635 ( 4.7A)
None
A  2 601 ( 4.5A)
 0.67A 3cyxA-5xyiE:
undetectable		 3cyxA-5xyiE:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 3 ARG A 689
VAL A 263
THR A 602
 None
 0.76A 3cyxA-5yemA:
undetectable		 3cyxA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvf -

(-) 		no annotation 3 ARG A 217
VAL A 145
THR A 140
 None
 0.57A 3cyxA-5yvfA:
undetectable		 3cyxA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq9 DNA TOPOISOMERASE 4
SUBUNIT A

(Pseudomonas
putida) 		no annotation 3 ARG A  36
VAL A 187
THR A 176
 CL  A 502 (-4.1A)
None
None
 0.83A 3cyxA-6bq9A:
undetectable		 3cyxA-6bq9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 ARG A 929
VAL A 919
THR A 862
 None
 0.79A 3cyxA-6ez8A:
undetectable		 3cyxA-6ez8A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 3 ARG A 592
VAL A 631
THR A 603
 None
 0.53A 3cyxA-6f2tA:
undetectable		 3cyxA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 294
VAL A  15
THR A 302
 None
 0.68A 3cyxA-6f91A:
undetectable		 3cyxA-6f91A:
19.80