SIMILAR PATTERNS OF AMINO ACIDS FOR 3CV9_A_VDXA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b43 PROTEIN (FEN-1)

(Pyrococcus
furiosus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 VAL A 253
SER A 256
LEU A 231
ILE A 230
ILE A   8
 None
 1.18A 3cv9A-1b43A:
undetectable		 3cv9A-1b43A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		5 VAL A 157
LEU A 205
ARG A 158
ILE A 202
GLY A 138
 None
 1.08A 3cv9A-1bxcA:
0.0		 3cv9A-1bxcA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 THR A 532
VAL A 509
ARG A 442
ILE A 433
ILE A 514
 None
 1.22A 3cv9A-1c4oA:
0.0		 3cv9A-1c4oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 SER A 423
LEU A 390
SER A 428
ILE A 387
GLY A 471
 None
 1.23A 3cv9A-1dcqA:
0.0		 3cv9A-1dcqA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 THR A 318
VAL A 291
ARG A 324
ILE A 145
GLY A  58
 None
 1.28A 3cv9A-1dj2A:
0.0		 3cv9A-1dj2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 VAL A  91
LEU A  98
SER A 119
ILE A 116
GLY A 240
 None
 1.18A 3cv9A-1dj2A:
0.0		 3cv9A-1dj2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 242
LEU A 340
SER A 310
ILE A 296
GLY A 298
 None
 0.84A 3cv9A-1eu1A:
0.0		 3cv9A-1eu1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5u PROFILIN

(Hevea
brasiliensis) 		PF00235
(Profilin) 		5 VAL A1119
LEU A1020
ILE A1105
ILE A1075
GLY A1077
 None
 1.24A 3cv9A-1g5uA:
undetectable		 3cv9A-1g5uA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 VAL A 169
LEU A 188
SER A 146
ILE A 187
GLY A 176
 None
 1.27A 3cv9A-1hyqA:
0.0		 3cv9A-1hyqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 VAL A  34
LEU A  97
SER A  88
ILE A 122
ILE A 160
 None
 1.19A 3cv9A-1i2dA:
0.0		 3cv9A-1i2dA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 VAL A 157
SER A 153
SER A 135
ILE A 252
ILE A 164
 None
 1.14A 3cv9A-1jihA:
undetectable		 3cv9A-1jihA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G) 		5 THR G  41
LEU G  32
ILE G 122
ILE G 112
GLY B  79
 None
 1.04A 3cv9A-1mtyG:
undetectable		 3cv9A-1mtyG:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 THR A 803
VAL A 810
LEU A 762
ILE A 787
GLY A 647
 None
 1.17A 3cv9A-1n5xA:
undetectable		 3cv9A-1n5xA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 VAL A 247
SER A  91
ARG A 246
ILE A 129
GLY A 120
 None
 1.16A 3cv9A-1nntA:
undetectable		 3cv9A-1nntA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		5 SER A  35
LEU A  12
ARG A   8
ILE A  47
GLY A  64
 None
 1.07A 3cv9A-1p4aA:
undetectable		 3cv9A-1p4aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		5 SER A  35
LEU A  12
ARG A   8
SER A  39
GLY A  64
 None
 1.19A 3cv9A-1p4aA:
undetectable		 3cv9A-1p4aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 THR A 269
SER A 123
SER A 176
ILE A 231
GLY A 226
 None
 1.07A 3cv9A-1pguA:
undetectable		 3cv9A-1pguA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 VAL A 204
LEU A 215
ILE A 217
ILE A 348
GLY A 350
 None
None
None
None
ADP  A 396 (-3.6A)
 1.11A 3cv9A-1phpA:
undetectable		 3cv9A-1phpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		5 THR A 268
LEU A 396
ILE A 400
ILE A 272
GLY A 439
 None
 1.19A 3cv9A-1t90A:
undetectable		 3cv9A-1t90A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila) 		PF00871
(Acetate_kinase) 		5 VAL A 375
LEU A 195
ARG A 376
SER A 369
GLY A 314
 None
 1.27A 3cv9A-1tuuA:
undetectable		 3cv9A-1tuuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 THR A 186
VAL A  74
ARG A  75
ILE A  26
GLY A   2
 None
 1.25A 3cv9A-1vplA:
undetectable		 3cv9A-1vplA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		5 THR A 395
VAL A 370
SER A 372
ILE A 392
GLY A 389
 None
 1.25A 3cv9A-1yw1A:
undetectable		 3cv9A-1yw1A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		5 THR A 537
VAL A 514
ARG A 447
ILE A 438
ILE A 519
 None
 1.20A 3cv9A-2d7dA:
undetectable		 3cv9A-2d7dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		5 VAL A 279
LEU A 101
ILE A 105
ILE A  69
GLY A  66
 None
 1.27A 3cv9A-2epjA:
undetectable		 3cv9A-2epjA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx5 HYPOTHETICAL PROTEIN

(Prochlorococcus
marinus) 		PF13279
(4HBT_2) 		5 VAL A 101
LEU A 140
SER A  40
ILE A 136
ILE A  69
 None
 1.17A 3cv9A-2hx5A:
undetectable		 3cv9A-2hx5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqk 5'-NUCLEOTIDASE SURE

(Aquifex
aeolicus) 		PF01975
(SurE) 		5 VAL A  73
LEU A 118
ILE A 117
ILE A 123
GLY A  92
 None
 1.27A 3cv9A-2wqkA:
undetectable		 3cv9A-2wqkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF04146
(YTH) 		5 LEU A  40
SER A  35
ILE A  72
ILE A  23
GLY A  81
 None
 1.18A 3cv9A-2yu6A:
undetectable		 3cv9A-2yu6A:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		6 LEU A 180
ARG A 193
SER A 236
ILE A 243
ILE A 293
GLY A 295
 VDX  A 501 (-4.2A)
VDX  A 501 (-3.5A)
VDX  A 501 (-3.3A)
VDX  A 501 (-4.2A)
VDX  A 501 (-4.9A)
HEM  A 413 ( 4.4A)
 1.10A 3cv9A-2zbzA:
70.2		 3cv9A-2zbzA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		9 THR A  81
VAL A  88
SER A  91
LEU A 180
ARG A 193
SER A 236
ILE A 243
ILE A 293
GLY A 296
 VDX  A 501 (-4.4A)
VDX  A 501 ( 4.4A)
VDX  A 501 (-4.3A)
VDX  A 501 (-4.2A)
VDX  A 501 (-3.5A)
VDX  A 501 (-3.3A)
VDX  A 501 (-4.2A)
VDX  A 501 (-4.9A)
None
 0.39A 3cv9A-2zbzA:
70.2		 3cv9A-2zbzA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		5 THR A 146
LEU A  61
SER A  47
ILE A 153
GLY A 156
 None
 1.19A 3cv9A-3afoA:
undetectable		 3cv9A-3afoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		5 THR A 146
SER A  46
LEU A  61
ILE A 153
GLY A 156
 None
 0.96A 3cv9A-3afoA:
undetectable		 3cv9A-3afoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		5 THR A  62
LEU A 113
SER A  77
ILE A  25
GLY A  34
 None
 1.14A 3cv9A-3alyA:
undetectable		 3cv9A-3alyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		5 VAL A 172
LEU A 220
ILE A  65
ILE A  55
GLY A  76
 None
 1.16A 3cv9A-3berA:
undetectable		 3cv9A-3berA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 THR A 874
LEU A 841
SER A 860
ILE A 828
GLY A 869
 None
 1.16A 3cv9A-3bwtA:
undetectable		 3cv9A-3bwtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile) 		PF08282
(Hydrolase_3) 		5 SER A 234
LEU A   7
ILE A 263
ILE A  51
GLY A  45
 None
None
None
None
PO4  A 274 (-3.7A)
 1.17A 3cv9A-3fzqA:
undetectable		 3cv9A-3fzqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 THR A 641
LEU A 584
SER A 505
ILE A 635
GLY A 637
 None
 1.12A 3cv9A-3gitA:
undetectable		 3cv9A-3gitA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 THR A 256
VAL A 409
LEU A 380
ILE A 376
GLY A 227
 None
 1.27A 3cv9A-3hwwA:
undetectable		 3cv9A-3hwwA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		5 LEU A 513
SER A 465
ILE A 694
ILE A 641
GLY A 656
 None
 1.18A 3cv9A-3la6A:
undetectable		 3cv9A-3la6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 THR A 177
LEU A 289
ARG A 264
SER A 241
GLY A 154
 None
None
XUL  A7778 ( 4.7A)
None
None
 1.16A 3cv9A-3ll3A:
undetectable		 3cv9A-3ll3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 140
SER A  17
ILE A  13
ILE A 125
GLY A 121
 None
 1.27A 3cv9A-3lxmA:
undetectable		 3cv9A-3lxmA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 224
SER A  65
ILE A 162
ILE A 204
GLY A 170
 None
 1.25A 3cv9A-3njbA:
undetectable		 3cv9A-3njbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		5 THR A  92
VAL A 154
SER A 179
ILE A  17
GLY A  94
 None
None
None
None
SO4  A 341 (-3.1A)
 1.20A 3cv9A-3nxkA:
undetectable		 3cv9A-3nxkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		5 VAL A 154
SER A 162
SER A 179
ILE A  17
GLY A  94
 None
None
None
None
SO4  A 341 (-3.1A)
 1.25A 3cv9A-3nxkA:
undetectable		 3cv9A-3nxkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o12 UNCHARACTERIZED
PROTEIN YJL217W

(Saccharomyces
cerevisiae) 		PF07081
(DUF1349) 		5 SER A 116
SER A 105
ILE A  81
ILE A  85
GLY A  88
 EDO  A 208 (-2.6A)
EDO  A 205 (-2.6A)
None
None
None
 1.07A 3cv9A-3o12A:
undetectable		 3cv9A-3o12A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		5 SER A 656
LEU A 685
ARG A 652
ILE A 634
GLY A 629
 None
 0.90A 3cv9A-3o4zA:
undetectable		 3cv9A-3o4zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 SER A 935
ARG A 711
ILE A 716
ILE A 642
GLY A 637
 None
 0.94A 3cv9A-3opyA:
undetectable		 3cv9A-3opyA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5s CD38 MOLECULE

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		5 THR A 195
VAL A 198
SER A 119
LEU A 252
ILE A 249
 None
None
AVU  A 280 (-2.9A)
None
None
 1.28A 3cv9A-3p5sA:
undetectable		 3cv9A-3p5sA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp4 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		5 THR A 140
LEU A  60
ILE A 150
ILE A 102
GLY A 107
 None
 1.18A 3cv9A-3qp4A:
undetectable		 3cv9A-3qp4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp5 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 THR A 140
LEU A  60
ILE A 150
ILE A 102
GLY A 107
 None
 0.99A 3cv9A-3qp5A:
undetectable		 3cv9A-3qp5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8r TRANSALDOLASE

(Bacillus
subtilis) 		PF00923
(TAL_FSA) 		5 LEU A 144
SER A 128
ILE A 145
ILE A 154
GLY A 156
 None
 1.28A 3cv9A-3r8rA:
undetectable		 3cv9A-3r8rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		5 VAL A  96
LEU A 103
ILE A 147
ILE A 142
GLY A 130
 None
 1.16A 3cv9A-3rrlA:
undetectable		 3cv9A-3rrlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR C 803
VAL C 810
LEU C 762
ILE C 787
GLY C 647
 None
 1.17A 3cv9A-3sr6C:
undetectable		 3cv9A-3sr6C:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 VAL A 287
ARG A 288
ILE A 312
ILE A 257
GLY A 235
 None
 1.19A 3cv9A-3tiaA:
undetectable		 3cv9A-3tiaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 VAL A 183
LEU A 288
SER A 248
ILE A 289
GLY A 299
 None
None
None
None
HEM  A 500 (-3.4A)
 0.99A 3cv9A-3tk3A:
32.4		 3cv9A-3tk3A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 LEU A 867
ARG A 833
SER A  33
ILE A 864
GLY A 488
 None
 1.23A 3cv9A-3ux8A:
undetectable		 3cv9A-3ux8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 THR A 142
SER A 164
ILE A 135
ILE A  80
GLY A  78
 None
 0.94A 3cv9A-3vr5A:
undetectable		 3cv9A-3vr5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		5 VAL A 242
LEU A 363
SER A 417
ILE A 258
ILE A 281
 None
 1.23A 3cv9A-4c3sA:
undetectable		 3cv9A-4c3sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eca L-ASPARAGINE
AMIDOHYDROLASE

(Escherichia
coli) 		PF00710
(Asparaginase) 		5 THR A  86
VAL A 148
SER A 173
ILE A  13
GLY A  88
 None
None
None
AEI  A  12 ( 4.4A)
AEI  A  12 ( 3.2A)
 1.24A 3cv9A-4ecaA:
undetectable		 3cv9A-4ecaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 THR A  16
LEU A 262
SER A 104
ILE A 375
GLY A 364
 None
 1.25A 3cv9A-4egvA:
undetectable		 3cv9A-4egvA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans) 		PF01036
(Bac_rhodopsin) 		5 SER A 156
LEU A 110
ILE A 107
ILE A  48
GLY A 220
 SO4  A 307 (-3.4A)
None
BNG  A 305 ( 3.8A)
None
None
 1.26A 3cv9A-4fbzA:
undetectable		 3cv9A-4fbzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 5 LEU B 120
SER B 261
ILE B 236
ILE B  73
GLY B  76
 None
 0.97A 3cv9A-4fdgB:
undetectable		 3cv9A-4fdgB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 VAL A 141
LEU A 319
ILE A 334
ILE A 308
GLY A  57
 None
 1.16A 3cv9A-4ggpA:
undetectable		 3cv9A-4ggpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 144
SER A 112
ILE A 122
ILE A  61
GLY A  35
 None
 1.15A 3cv9A-4gkvA:
undetectable		 3cv9A-4gkvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		5 VAL A 220
SER A 222
SER A 269
ILE A   3
GLY A 263
 None
None
10D  A 402 (-2.7A)
None
None
 1.11A 3cv9A-4h4cA:
undetectable		 3cv9A-4h4cA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 VAL A 287
ARG A 288
ILE A 312
ILE A 257
GLY A 235
 None
 1.20A 3cv9A-4h53A:
undetectable		 3cv9A-4h53A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 THR A  25
VAL A  20
LEU A  34
ILE A 572
GLY A 283
 FED  A 801 (-3.2A)
None
None
None
FED  A 801 (-3.5A)
 1.23A 3cv9A-4h7uA:
undetectable		 3cv9A-4h7uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 VAL A 300
LEU A 170
SER A 244
ILE A 148
GLY A 150
 None
 1.09A 3cv9A-4hjlA:
undetectable		 3cv9A-4hjlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw9 MECHANOSENSITIVE
CHANNEL MSCS

(Helicobacter
pylori) 		PF00924
(MS_channel) 		5 LEU A 144
SER A 128
ILE A 125
ILE A 114
GLY A 109
 None
 1.14A 3cv9A-4hw9A:
undetectable		 3cv9A-4hw9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 SER A  13
SER A 170
ILE A 136
ILE A   2
GLY A  24
 None
 1.26A 3cv9A-4iqfA:
undetectable		 3cv9A-4iqfA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 VAL A 106
LEU A  84
ILE A  87
ILE A 151
GLY A 133
 None
 1.05A 3cv9A-4oanA:
undetectable		 3cv9A-4oanA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 THR A  80
VAL A 140
SER A 165
ILE A  12
GLY A  82
 None
None
None
None
PO4  A 401 (-3.0A)
 1.17A 3cv9A-4q0mA:
undetectable		 3cv9A-4q0mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 THR A  80
VAL A 140
SER A 165
ILE A  12
GLY A  82
 None
 1.16A 3cv9A-4ra6A:
undetectable		 3cv9A-4ra6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 5 THR A 275
SER A 155
ILE A 152
ILE A  14
GLY A 106
 3S4  A 402 (-3.7A)
None
None
None
ADP  A 401 (-3.4A)
 1.13A 3cv9A-4rkzA:
undetectable		 3cv9A-4rkzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		5 VAL A 104
ARG A 102
SER A  89
ILE A  67
GLY A 110
 None
 1.15A 3cv9A-4rzzA:
undetectable		 3cv9A-4rzzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		5 THR B  38
VAL B 126
SER B 124
ILE B   8
GLY B  82
 None
 1.19A 3cv9A-4s1iB:
undetectable		 3cv9A-4s1iB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A 294
SER A 129
ILE A 286
ILE A 281
GLY A 157
 None
 1.20A 3cv9A-4tweA:
undetectable		 3cv9A-4tweA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2m MTR2

(Chaetomium
thermophilum) 		no annotation 5 VAL A  12
SER A  10
LEU A 155
ILE A 175
GLY A 129
 None
 1.21A 3cv9A-4x2mA:
undetectable		 3cv9A-4x2mA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 THR A  80
VAL A 140
SER A 165
ILE A  12
GLY A  82
 None
None
GOL  A 207 (-4.6A)
None
ASP  A 201 (-3.1A)
 1.17A 3cv9A-5b5uA:
undetectable		 3cv9A-5b5uA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 THR A1229
VAL A1186
SER A1191
ILE A1261
ILE A1238
 None
 1.22A 3cv9A-5cs4A:
undetectable		 3cv9A-5cs4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 THR A1229
VAL A1186
SER A1191
ILE A1261
ILE A1238
 None
 1.27A 3cv9A-5csaA:
undetectable		 3cv9A-5csaA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 THR H 306
LEU H 104
ARG H 103
ILE H 252
GLY H 255
 None
 1.26A 3cv9A-5dfwH:
undetectable		 3cv9A-5dfwH:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 258
SER A 447
ILE A 268
ILE A 441
GLY A 428
 None
 1.00A 3cv9A-5erbA:
undetectable		 3cv9A-5erbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE

(Thermosynechococcus
elongatus) 		PF01716
(MSP) 		5 THR A 133
SER A 168
LEU A 118
ILE A  74
ILE A 129
 None
 1.23A 3cv9A-5g39A:
undetectable		 3cv9A-5g39A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 5 VAL Y 363
SER Y 361
LEU Y 397
ILE Y 429
GLY Y 324
 None
 1.23A 3cv9A-5gaiY:
undetectable		 3cv9A-5gaiY:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		5 LEU A  86
SER A  70
ILE A 166
ILE A  51
GLY A 262
 None
 1.02A 3cv9A-5huqA:
undetectable		 3cv9A-5huqA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		5 THR A  95
VAL A 318
SER A 308
ILE A 336
GLY A  87
 None
 1.03A 3cv9A-5j90A:
undetectable		 3cv9A-5j90A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		5 THR A  95
VAL A 318
SER A 334
ILE A 336
GLY A  87
 None
 1.27A 3cv9A-5j90A:
undetectable		 3cv9A-5j90A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jos CYCLOHEXADIENYL
DEHYDRATASE

(synthetic
construct) 		PF00497
(SBP_bac_3) 		5 VAL A 224
LEU A  16
SER A  59
ILE A  19
GLY A 210
 None
 1.11A 3cv9A-5josA:
undetectable		 3cv9A-5josA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 THR A 222
VAL A 234
ARG A  34
ILE A  15
GLY A  44
 None
None
None
None
FAD  A1801 (-3.4A)
 1.11A 3cv9A-5laeA:
undetectable		 3cv9A-5laeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp4 PROTOPLAST SECRETED
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 VAL A   4
SER A  32
ARG A   3
ILE A 136
GLY A 109
 None
 1.20A 3cv9A-5mp4A:
undetectable		 3cv9A-5mp4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7z LIPOPOLYSACCHARIDE
1,6-GALACTOSYLTRANSF
ERASE

(Salmonella
enterica) 		no annotation 5 THR A 336
SER A 142
LEU A 305
SER A 291
ILE A 333
 None
 1.21A 3cv9A-5n7zA:
undetectable		 3cv9A-5n7zA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 5 THR A  82
VAL A 142
SER A 167
ILE A  12
GLY A  84
 None
None
None
None
PO4  A 401 (-3.0A)
 1.15A 3cv9A-5ot0A:
undetectable		 3cv9A-5ot0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp0 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Aliivibrio
fischeri) 		PF02540
(NAD_synthase) 		5 VAL A  78
SER A 105
ARG A  79
ILE A  98
GLY A 161
 None
 1.07A 3cv9A-5wp0A:
undetectable		 3cv9A-5wp0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		5 VAL A 853
SER A 950
ILE A 955
ILE A 795
GLY A1133
 None
 1.17A 3cv9A-5x59A:
undetectable		 3cv9A-5x59A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00573
(Ribosomal_L4) 		5 THR E  68
VAL E 169
SER E 167
LEU E 245
ILE E  57
 None
 1.26A 3cv9A-5x8tE:
undetectable		 3cv9A-5x8tE:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		5 VAL A 467
LEU A 451
ARG A 465
ILE A 633
ILE A 624
 None
 1.18A 3cv9A-5y7oA:
undetectable		 3cv9A-5y7oA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 THR A 218
VAL A 203
LEU A 189
ILE A  66
GLY A 231
 None
 1.25A 3cv9A-6c4gA:
undetectable		 3cv9A-6c4gA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 VAL A 233
LEU A 152
ILE A 186
ILE A 210
GLY A 172
 None
 1.22A 3cv9A-6czmA:
undetectable		 3cv9A-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 SER A  68
ARG A 408
ILE A 412
ILE A 100
GLY A 324
 None
None
None
HEM  A 604 (-3.0A)
HEM  A 604 (-3.4A)
 1.27A 3cv9A-6ercA:
undetectable		 3cv9A-6ercA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 5 VAL A1063
LEU A 880
ARG A1064
ILE A 873
GLY A 979
 None
None
None
None
SEP  A 954 ( 3.9A)
 1.21A 3cv9A-6fj4A:
undetectable		 3cv9A-6fj4A:
12.68