SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_D_NILD600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 LEU A  50
VAL A  83
LEU A  73
ASP A 107
 None
 0.85A 3cs9D-1ag9A:
undetectable		 3cs9D-1ag9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		4 LEU A 263
VAL A 235
LEU A 275
ASP A 280
 None
 0.76A 3cs9D-1fs2A:
undetectable		 3cs9D-1fs2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 158
VAL A 166
LYS A 181
ASP A 275
 None
 0.78A 3cs9D-1gzkA:
20.5		 3cs9D-1gzkA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  70
VAL A  78
LYS A  93
LEU A 193
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
STU  A 401 (-4.7A)
 0.71A 3cs9D-1nxkA:
18.1		 3cs9D-1nxkA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
TYR A 272
VAL A 275
LYS A 290
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 (-4.4A)
 0.72A 3cs9D-1opkA:
33.0		 3cs9D-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A 175
TYR A 178
VAL A 181
LEU A 132
 None
 0.88A 3cs9D-1r5aA:
undetectable		 3cs9D-1r5aA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
LEU A 799
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.78A 3cs9D-1t46A:
33.1		 3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
LYS A 623
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.9A)
 0.88A 3cs9D-1t46A:
33.1		 3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 344
VAL A 352
LYS A 369
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.84A 3cs9D-1u59A:
29.8		 3cs9D-1u59A:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 LEU A  79
VAL A 127
LEU A  64
ASP A 114
 None
 0.81A 3cs9D-1uz4A:
undetectable		 3cs9D-1uz4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		4 LEU B2251
VAL B2223
LEU B2263
ASP B2268
 None
 0.82A 3cs9D-2assB:
undetectable		 3cs9D-2assB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LEU A  19
VAL A  27
LYS A  42
ASP A 156
 None
 0.66A 3cs9D-2bdwA:
20.8		 3cs9D-2bdwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  26
VAL A  34
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.8A)
None
 0.84A 3cs9D-2bujA:
22.3		 3cs9D-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  26
VAL A  34
LYS A  49
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.66A 3cs9D-2bujA:
22.3		 3cs9D-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
VAL A 170
LYS A 186
LEU A 290
 None
 0.77A 3cs9D-2eu9A:
20.5		 3cs9D-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		4 LEU A  49
VAL A  87
LEU A  77
ASP A 111
 None
 0.84A 3cs9D-2fcrA:
undetectable		 3cs9D-2fcrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
VAL A  63
LYS A  78
LEU A 177
 None
 0.71A 3cs9D-2hw6A:
18.6		 3cs9D-2hw6A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
None
 0.68A 3cs9D-2jamA:
17.8		 3cs9D-2jamA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
 0.75A 3cs9D-2jc6A:
15.7		 3cs9D-2jc6A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus) 		PF01115
(F_actin_cap_B)
PF01267
(F-actin_cap_A) 		4 LEU B 310
VAL B 343
LEU A  39
ASP B 327
 None
 0.83A 3cs9D-2kxpB:
undetectable		 3cs9D-2kxpB:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
LEU A 371
ASP A 382
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.97A 3cs9D-2og8A:
26.6		 3cs9D-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 838
LYS A 855
LEU A 971
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.2A)
 0.61A 3cs9D-2p4iA:
23.6		 3cs9D-2p4iA:
37.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 LEU A  25
VAL A  33
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.81A 3cs9D-2phkA:
21.0		 3cs9D-2phkA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
VAL A  60
LYS A  75
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 (-4.9A)
 0.65A 3cs9D-2w4oA:
19.6		 3cs9D-2w4oA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		4 LEU A 540
TYR A 545
VAL A 538
ASP A 567
 None
 0.89A 3cs9D-2wozA:
undetectable		 3cs9D-2wozA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y77 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		4 LEU A  97
VAL A  72
LEU A  86
ASP A  60
 None
None
None
SO4  A1147 ( 4.2A)
 0.90A 3cs9D-2y77A:
undetectable		 3cs9D-2y77A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  68
VAL A  76
LYS A  94
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
 0.58A 3cs9D-2z7rA:
20.7		 3cs9D-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 539
LYS A 553
LEU A 654
ASP A 664
 None
7PE  A   1 (-2.6A)
None
None
 0.78A 3cs9D-2zmcA:
21.7		 3cs9D-2zmcA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 484
VAL A 492
LYS A 514
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-4.6A)
 0.67A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 LEU A 235
VAL A 265
LEU A 166
ASP A 240
 None
 0.87A 3cs9D-3ctzA:
undetectable		 3cs9D-3ctzA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 647
LYS A 665
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.76A 3cs9D-3dkoA:
27.9		 3cs9D-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
LYS A  38
LEU A 173
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 (-4.4A)
 0.38A 3cs9D-3eb0A:
20.6		 3cs9D-3eb0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.8A)
 0.57A 3cs9D-3f2aA:
16.8		 3cs9D-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
VAL A  67
LYS A  82
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
STU  A   1 (-4.4A)
 0.63A 3cs9D-3fmeA:
17.8		 3cs9D-3fmeA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
None
None
 0.95A 3cs9D-3hngA:
31.7		 3cs9D-3hngA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  82
VAL A  90
LYS A 105
LEU A 206
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
 0.60A 3cs9D-3hztA:
17.7		 3cs9D-3hztA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A 141
VAL A 149
LYS A 164
LEU A 267
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
None
 0.84A 3cs9D-3is5A:
17.4		 3cs9D-3is5A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 VAL A  27
LYS A  42
LEU A 142
ASP A 156
 None
 0.87A 3cs9D-3kl8A:
21.7		 3cs9D-3kl8A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  39
VAL A  47
LYS A  62
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
 0.72A 3cs9D-3lm5A:
22.4		 3cs9D-3lm5A:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcs PUTATIVE
MONOOXYGENASE

(Fusobacterium
nucleatum) 		PF03992
(ABM) 		5 LEU A   7
TYR A 150
VAL A  98
LEU A  41
ASP A 213
 None
 1.49A 3cs9D-3mcsA:
undetectable		 3cs9D-3mcsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 171
VAL A 179
LYS A 194
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.2A)
 0.82A 3cs9D-3mtlA:
20.3		 3cs9D-3mtlA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  49
VAL A  57
LYS A  72
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
XFE  A 351 (-4.6A)
 0.77A 3cs9D-3mvjA:
19.6		 3cs9D-3mvjA:
24.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 726
VAL A 734
LYS A 753
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
 0.82A 3cs9D-3pp0A:
24.8		 3cs9D-3pp0A:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 268
TYR A 238
VAL A 270
LEU A 222
ASP A 218
 None
 1.50A 3cs9D-3ppcA:
undetectable		 3cs9D-3ppcA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  63
VAL A  71
LYS A  86
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.4A)
 0.78A 3cs9D-3q5iA:
19.0		 3cs9D-3q5iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
 0.82A 3cs9D-3qkaA:
undetectable		 3cs9D-3qkaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 LEU A  57
VAL A  20
LEU A  96
ASP A  49
 None
 0.84A 3cs9D-3r9qA:
undetectable		 3cs9D-3r9qA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  50
VAL A  58
LYS A  73
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
 0.76A 3cs9D-3sheA:
17.2		 3cs9D-3sheA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 484
VAL A 492
LYS A 514
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 ( 4.4A)
 0.53A 3cs9D-3tt0A:
29.7		 3cs9D-3tt0A:
35.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 361
VAL A 369
LYS A 384
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-4.3A)
 0.80A 3cs9D-3txoA:
16.9		 3cs9D-3txoA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
VAL A 552
LEU A 686
ASP A 697
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.5A)
None
 0.82A 3cs9D-3v5qA:
32.9		 3cs9D-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
VAL A 552
LYS A 572
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
0F4  A 902 (-4.5A)
 0.81A 3cs9D-3v5qA:
32.9		 3cs9D-3v5qA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 402
VAL A 398
LEU A 515
ASP A 510
 None
 0.90A 3cs9D-3vf1A:
undetectable		 3cs9D-3vf1A:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.8A)
None
 0.68A 3cs9D-3vidA:
29.6		 3cs9D-3vidA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 139
VAL A 147
LYS A 162
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.5A)
 0.82A 3cs9D-3w18A:
21.6		 3cs9D-3w18A:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
LYS A 868
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-4.8A)
 0.53A 3cs9D-3wzdA:
30.9		 3cs9D-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 479
LYS A 507
LEU A 622
ASP A 633
 None
 0.79A 3cs9D-3zzwA:
28.0		 3cs9D-3zzwA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 479
VAL A 487
LYS A 507
ASP A 633
 None
 0.89A 3cs9D-3zzwA:
28.0		 3cs9D-3zzwA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
VAL A 568
LYS A 588
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.2A)
 0.74A 3cs9D-4at3A:
33.5		 3cs9D-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  42
VAL A  50
LYS A  65
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.7A)
 0.68A 3cs9D-4bc6A:
20.9		 3cs9D-4bc6A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 LEU A  65
TYR A  68
LEU A  56
ASP A  71
 None
 0.82A 3cs9D-4be3A:
undetectable		 3cs9D-4be3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		4 LEU A 246
VAL A 254
LYS A 269
LEU A 371
 None
 0.70A 3cs9D-4c0tA:
20.4		 3cs9D-4c0tA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  22
VAL A  30
LYS A  45
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
 0.72A 3cs9D-4cfhA:
21.7		 3cs9D-4cfhA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 655
LEU A 773
ASP A 784
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
 0.72A 3cs9D-4ckrA:
31.4		 3cs9D-4ckrA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 855
VAL A 863
LYS A 882
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.7A)
 0.73A 3cs9D-4gl9A:
20.7		 3cs9D-4gl9A:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 828
VAL A 836
LYS A 855
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.5A)
 0.66A 3cs9D-4hviA:
28.7		 3cs9D-4hviA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
VAL A  26
LYS A  41
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
EDO  A 302 (-3.7A)
 0.66A 3cs9D-4jxfA:
19.8		 3cs9D-4jxfA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
VAL A  26
LYS A  41
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.0A)
 0.50A 3cs9D-4jxfA:
19.8		 3cs9D-4jxfA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		4 LEU A  63
VAL A  26
LEU A 106
ASP A  55
 None
 0.86A 3cs9D-4mouA:
undetectable		 3cs9D-4mouA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
LYS A 642
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
2TT  A1201 (-4.1A)
 0.89A 3cs9D-4oliA:
26.3		 3cs9D-4oliA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
LYS A 930
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
2TT  A1202 (-4.4A)
 0.85A 3cs9D-4oliA:
26.3		 3cs9D-4oliA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A6345
VAL A6126
LEU A6288
ASP A6122
 None
 0.90A 3cs9D-4opfA:
undetectable		 3cs9D-4opfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 332
VAL A 329
LEU A 288
ASP A 338
 None
 0.82A 3cs9D-4p3zA:
undetectable		 3cs9D-4p3zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
None
EDO  A 303 (-4.0A)
None
 0.81A 3cs9D-4qfeA:
undetectable		 3cs9D-4qfeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  24
VAL A  32
LYS A  47
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.2A)
 0.60A 3cs9D-4rewA:
21.6		 3cs9D-4rewA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.97A 3cs9D-4rt7A:
29.2		 3cs9D-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
VAL A  22
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 ( 4.8A)
None
 0.83A 3cs9D-4ueuA:
31.7		 3cs9D-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 LEU A 104
VAL A 112
LYS A 127
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
ATP  A 501 (-4.5A)
 0.78A 3cs9D-4wb7A:
19.6		 3cs9D-4wb7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A 193
VAL A 201
LYS A 216
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-4.9A)
 0.77A 3cs9D-4wboA:
20.9		 3cs9D-4wboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
VAL A  60
LYS A  74
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
KSA  A 405 (-4.6A)
 0.85A 3cs9D-4wsqA:
21.9		 3cs9D-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 473
VAL A 481
LYS A 503
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
 0.61A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.3A)
None
 0.81A 3cs9D-4xufA:
32.3		 3cs9D-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  34
VAL A  42
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.82A 3cs9D-4ysjA:
21.9		 3cs9D-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
 0.88A 3cs9D-4z0mA:
undetectable		 3cs9D-4z0mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0n ENOYL-COA
HYDRATASE/ISOMERASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU X  57
VAL X  20
LEU X 105
ASP X  49
 None
 0.86A 3cs9D-5e0nX:
undetectable		 3cs9D-5e0nX:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		4 LEU A  99
VAL A 107
LYS A 122
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
None
 0.46A 3cs9D-5eykA:
8.9		 3cs9D-5eykA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
LYS A 930
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.4A)
 0.70A 3cs9D-5f1zA:
23.7		 3cs9D-5f1zA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 607
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.77A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 607
LYS A 627
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.81A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
VAL A  65
LYS A  79
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-4.4A)
 0.88A 3cs9D-5i3oA:
21.7		 3cs9D-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  22
VAL A  30
LYS A  45
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.5A)
 0.70A 3cs9D-5isoA:
21.9		 3cs9D-5isoA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 647
LYS A 665
LEU A 765
ASP A 776
 None
None
6P6  A1001 (-4.5A)
None
 0.85A 3cs9D-5l6oA:
32.7		 3cs9D-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 LEU A 468
VAL A 476
LYS A 491
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
 0.61A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 VAL A 476
LYS A 491
LEU A 599
ASP A 613
 AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.80A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 None
7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
 0.57A 3cs9D-5turA:
20.4		 3cs9D-5turA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 4 LEU A 891
VAL A 899
LYS A 919
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
 0.72A 3cs9D-5wnoA:
27.2		 3cs9D-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 LEU A 778
VAL A 776
LEU A 890
ASP A 770
 None
 0.73A 3cs9D-6ax6A:
undetectable		 3cs9D-6ax6A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 VAL A 539
LYS A 553
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-4.5A)
None
 0.74A 3cs9D-6b4wA:
21.0		 3cs9D-6b4wA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 4 VAL A 701
LYS A 717
LEU A 822
ASP A 834
 919  A1101 (-4.7A)
SO4  A1102 ( 2.8A)
None
919  A1101 (-4.5A)
 0.59A 3cs9D-6cnhA:
20.5		 3cs9D-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 175
LYS A 191
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
 0.87A 3cs9D-6fyvA:
20.5		 3cs9D-6fyvA:
undetectable