SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_D_NILD600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
HIS A 519
 None
 0.59A 3cs9D-1k2pA:
25.6		 3cs9D-1k2pA:
45.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
LEU A 248
THR A 266
GLY A 272
 None
 0.56A 3cs9D-1k9aA:
30.2		 3cs9D-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
VAL A 239
MET A 240
THR A 266
GLY A 272
 None
 0.52A 3cs9D-1k9aA:
30.2		 3cs9D-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
 None
 0.40A 3cs9D-1k9aA:
30.2		 3cs9D-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
GLY A 660
PHE A 720
HIS A 722
ALA A 741
 None
 0.49A 3cs9D-1lufA:
34.1		 3cs9D-1lufA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ALA A 288
GLU A 305
VAL A 308
MET A 309
LEU A 317
THR A 334
PHE A 336
GLY A 340
HIS A 380
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
 0.59A 3cs9D-1opkA:
33.0		 3cs9D-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
ALA A 399
 P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
 0.72A 3cs9D-1opkA:
33.0		 3cs9D-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 389
LEU A 418
PHE A 437
GLY A 441
HIS A 480
 None
 0.48A 3cs9D-1snxA:
22.6		 3cs9D-1snxA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
VAL A 643
THR A 670
GLY A 676
HIS A 790
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
 0.49A 3cs9D-1t46A:
33.1		 3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
GLU X  54
MET X  58
LEU X  66
THR X  82
GLY X  88
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
 0.59A 3cs9D-2dq7X:
31.1		 3cs9D-2dq7X:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
MET X  58
LEU X  66
THR X  82
GLY X  88
HIS X 128
ALA X 147
 STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
STU  X 902 ( 4.1A)
 0.45A 3cs9D-2dq7X:
31.1		 3cs9D-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
THR A 338
GLY A 344
HIS A 384
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
 0.50A 3cs9D-2h8hA:
29.5		 3cs9D-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
PHE A 340
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.38A 3cs9D-2hckA:
29.0		 3cs9D-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
THR A 338
PHE A 340
GLY A 344
HIS A 384
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
None
 0.51A 3cs9D-2hckA:
29.0		 3cs9D-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
 0.61A 3cs9D-2henA:
26.5		 3cs9D-2henA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.60A 3cs9D-2hk5A:
27.2		 3cs9D-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
MET A 292
LEU A 300
THR A 316
PHE A 318
GLY A 322
HIS A 362
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
 0.66A 3cs9D-2hk5A:
27.2		 3cs9D-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.71A 3cs9D-2hk5A:
27.2		 3cs9D-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
VAL A 289
MET A 290
ILE A 293
LEU A 298
THR A 315
PHE A 317
GLY A 321
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-3.1A)
 0.60A 3cs9D-2hz0A:
32.8		 3cs9D-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
VAL A 289
MET A 290
ILE A 293
LEU A 298
THR A 315
PHE A 317
GLY A 321
HIS A 361
ALA A 380
 GIN  A 600 (-3.1A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
 0.69A 3cs9D-2hz0A:
32.8		 3cs9D-2hz0A:
98.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
GLY A 505
PHE A 542
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
None
 0.61A 3cs9D-2j0jA:
32.1		 3cs9D-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
GLY A 505
PHE A 542
HIS A 544
 BII  A1687 (-3.5A)
None
None
BII  A1687 (-3.6A)
None
None
 0.67A 3cs9D-2jkmA:
32.0		 3cs9D-2jkmA:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
GLU A 288
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
ALA A 381
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 3.3A)
 0.45A 3cs9D-2og8A:
26.6		 3cs9D-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
MET A 637
THR A 663
GLY A 669
HIS A 776
 None
 0.52A 3cs9D-2ogvA:
31.7		 3cs9D-2ogvA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
VAL A 875
GLY A 908
HIS A 962
ALA A 981
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.8A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
 0.34A 3cs9D-2p4iA:
23.6		 3cs9D-2p4iA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.68A 3cs9D-2psqA:
31.0		 3cs9D-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 None
 0.52A 3cs9D-2psqA:
31.0		 3cs9D-2psqA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
GLU A 230
LEU A 244
THR A 265
PHE A 267
GLY A 271
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
 0.59A 3cs9D-2qluA:
23.9		 3cs9D-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 1.27A 3cs9D-2qluA:
23.9		 3cs9D-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LEU A 244
THR A 265
PHE A 267
GLY A 271
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 0.53A 3cs9D-2qluA:
23.9		 3cs9D-2qluA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1028
VAL A1050
MET A1051
GLY A1082
HIS A1130
 S91  A   1 (-3.2A)
None
None
S91  A   1 (-3.3A)
None
 0.53A 3cs9D-2z8cA:
23.3		 3cs9D-2z8cA:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
GLU A 290
MET A 294
THR A 319
PHE A 321
 None
 0.60A 3cs9D-2zv7A:
25.8		 3cs9D-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 273
LEU A 302
THR A 319
PHE A 321
GLY A 325
HIS A 365
ALA A 384
 None
 0.58A 3cs9D-2zv7A:
25.8		 3cs9D-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 273
MET A 294
LEU A 302
THR A 319
PHE A 321
HIS A 365
ALA A 384
 None
 0.73A 3cs9D-2zv7A:
25.8		 3cs9D-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
 0.57A 3cs9D-3b2tA:
25.5		 3cs9D-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.66A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.72A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
LEU A 248
THR A 266
GLY A 272
 None
 0.56A 3cs9D-3d7uA:
27.1		 3cs9D-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
VAL A 239
MET A 240
THR A 266
GLY A 272
 None
 0.52A 3cs9D-3d7uA:
27.1		 3cs9D-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
 None
 0.40A 3cs9D-3d7uA:
27.1		 3cs9D-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
MET A 688
THR A 713
GLY A 719
HIS A 758
 None
None
None
GOL  A 403 (-3.4A)
None
 0.44A 3cs9D-3kulA:
31.1		 3cs9D-3kulA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1031
VAL A1053
GLY A1085
PHE A1131
HIS A1133
 None
None
None
None
CCX  A   1 (-4.0A)
 0.58A 3cs9D-3lw0A:
31.7		 3cs9D-3lw0A:
44.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
THR A 279
GLY A 285
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 ( 3.8A)
 0.38A 3cs9D-3mdyA:
24.3		 3cs9D-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 227
THR A 277
GLY A 283
HIS A 328
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 ( 3.8A)
 0.35A 3cs9D-3my0A:
23.8		 3cs9D-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 109
GLU A 130
MET A 134
GLY A 165
HIS A 203
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
 0.59A 3cs9D-3nuuA:
21.7		 3cs9D-3nuuA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
MET A 600
THR A 625
GLY A 631
HIS A 674
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.34A 3cs9D-3ppzA:
27.7		 3cs9D-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 GLU A 596
MET A 600
THR A 625
GLY A 631
HIS A 674
 None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.64A 3cs9D-3ppzA:
27.7		 3cs9D-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
GLU A 232
VAL A 235
THR A 267
PHE A 269
GLY A 273
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
 0.68A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
THR A 267
PHE A 269
GLY A 273
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
None
TAK  A   2 ( 4.2A)
 0.49A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
VAL A 235
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.62A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 443
MET A 464
LEU A 472
THR A 489
GLY A 495
HIS A 534
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
 0.40A 3cs9D-3sxsA:
30.9		 3cs9D-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
None
07J  A   1 (-3.2A)
 0.64A 3cs9D-3tt0A:
29.7		 3cs9D-3tt0A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
None
07J  A   1 (-3.2A)
 0.74A 3cs9D-3tt0A:
29.7		 3cs9D-3tt0A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
HIS A1026
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.65A 3cs9D-3vidA:
29.7		 3cs9D-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
None
 0.59A 3cs9D-3wzdA:
30.9		 3cs9D-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.62A 3cs9D-3zfxA:
31.4		 3cs9D-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
THR A 697
PHE A 699
GLY A 703
HIS A 742
 None
 0.53A 3cs9D-3zfxA:
31.4		 3cs9D-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
 0.71A 3cs9D-4agdA:
31.7		 3cs9D-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
HIS A 214
 30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
 0.98A 3cs9D-4aw5A:
27.2		 3cs9D-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 121
THR A 169
PHE A 171
GLY A 175
HIS A 214
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
None
 0.62A 3cs9D-4aw5A:
27.2		 3cs9D-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
PHE A 112
GLY A 116
HIS A 155
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
None
XZN  A1317 ( 4.3A)
 0.48A 3cs9D-4bc6A:
20.9		 3cs9D-4bc6A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 233
THR A 283
GLY A 289
HIS A 334
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 ( 4.2A)
 0.27A 3cs9D-4c02A:
24.0		 3cs9D-4c02A:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
GLU A 672
MET A 676
THR A 701
HIS A 764
ALA A 783
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
 0.70A 3cs9D-4ckrA:
31.4		 3cs9D-4ckrA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
MET A 676
THR A 701
GLY A 707
HIS A 764
ALA A 783
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
 0.71A 3cs9D-4ckrA:
31.4		 3cs9D-4ckrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  36
GLU A  55
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.65A 3cs9D-4eutA:
12.1		 3cs9D-4eutA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  36
GLU A  55
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.46A 3cs9D-4euuA:
4.0		 3cs9D-4euuA:
24.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 400
GLU A 420
VAL A 423
MET A 424
GLY A 454
 0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
 0.57A 3cs9D-4f4pA:
29.9		 3cs9D-4f4pA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 538
PHE A 595
GLY A 599
PHE A 641
HIS A 643
ALA A 662
 0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0T8  A 901 ( 4.5A)
 0.60A 3cs9D-4feqA:
23.1		 3cs9D-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
LEU A 189
GLY A 211
PHE A 248
HIS A 250
 None
 0.50A 3cs9D-4hzsA:
26.6		 3cs9D-4hzsA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
 None
 0.64A 3cs9D-4hzsA:
26.6		 3cs9D-4hzsA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
 1G0  A 401 (-3.6A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
 0.61A 3cs9D-4id7A:
24.5		 3cs9D-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-3.5A)
 0.34A 3cs9D-4k11A:
29.2		 3cs9D-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
MET A 529
ILE A 532
GLY A 561
HIS A 615
ALA A 634
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 ( 4.6A)
None
None
 0.57A 3cs9D-4k33A:
26.3		 3cs9D-4k33A:
38.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 ( 4.2A)
 0.43A 3cs9D-4lggA:
29.1		 3cs9D-4lggA:
46.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
THR A  95
PHE A  97
GLY A 101
HIS A 141
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
None
None
 0.85A 3cs9D-4m69A:
23.1		 3cs9D-4m69A:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
LEU A  64
THR A  81
GLY A  87
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
 0.32A 3cs9D-4ueuA:
31.7		 3cs9D-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  72
MET A  94
PHE A 128
GLY A 132
HIS A 174
 KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
None
 0.56A 3cs9D-4wsqA:
21.9		 3cs9D-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
GLU A 520
VAL A 523
MET A 524
GLY A 556
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-3.0A)
 0.58A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
HIS A 610
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
None
 0.59A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 ALA B 288
VAL B 308
MET B 309
ILE B 312
LEU B 317
PHE B 336
GLY B 340
HIS B 380
ALA B 399
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
None
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
 0.68A 3cs9D-4xeyB:
33.6		 3cs9D-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 ALA B 288
VAL B 308
MET B 309
LEU B 317
THR B 334
PHE B 336
GLY B 340
HIS B 380
ALA B 399
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
 0.52A 3cs9D-4xeyB:
33.6		 3cs9D-4xeyB:
74.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
 0.49A 3cs9D-4y93A:
30.4		 3cs9D-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
 0.49A 3cs9D-4y93A:
30.4		 3cs9D-4y93A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
EDO  A1766 ( 4.4A)
 0.55A 3cs9D-5a46A:
29.7		 3cs9D-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
None
EDO  A1766 ( 4.4A)
 0.72A 3cs9D-5a46A:
29.7		 3cs9D-5a46A:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
ILE A 293
THR A 325
PHE A 327
GLY A 331
HIS A 377
 STU  A 601 (-3.1A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
None
 1.36A 3cs9D-5e8yA:
18.7		 3cs9D-5e8yA:
27.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
 0.61A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
GLY A1163
PHE A1200
HIS A1202
ALA A1221
 63K  A1401 (-3.5A)
63K  A1401 (-3.6A)
None
None
63K  A1401 (-3.3A)
 0.52A 3cs9D-5horA:
26.5		 3cs9D-5horA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A1131
GLY A1163
PHE A1200
HIS A1202
ALA A1221
 None
63K  A1401 (-3.6A)
None
None
63K  A1401 (-3.3A)
 0.65A 3cs9D-5horA:
26.5		 3cs9D-5horA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.75A 3cs9D-5j5tA:
20.4		 3cs9D-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
MET A  65
PHE A  92
GLY A  96
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
 0.54A 3cs9D-5j5tA:
20.4		 3cs9D-5j5tA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 663
MET A 686
THR A 711
PHE A 713
HIS A 756
 6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
DIO  A1002 (-4.1A)
 0.59A 3cs9D-5l6oA:
32.7		 3cs9D-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
GLU A 927
LEU A 939
PHE A 958
GLY A 962
 ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
 0.64A 3cs9D-5lpyA:
21.8		 3cs9D-5lpyA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
LEU A 939
PHE A 958
GLY A 962
HIS A1007
 ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
None
 0.42A 3cs9D-5lpyA:
21.8		 3cs9D-5lpyA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
LEU A 939
PHE A 958
GLY A 962
HIS A1007
 ADP  A1200 (-3.5A)
None
ADP  A1200 (-4.1A)
ADP  A1200 ( 4.0A)
None
 0.41A 3cs9D-5lpzA:
21.8		 3cs9D-5lpzA:
28.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 617
MET A 641
GLY A 677
PHE A 719
HIS A 721
ALA A 740
 7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
None
None
7AE  A1000 ( 3.7A)
 0.66A 3cs9D-5td2A:
22.2		 3cs9D-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 617
MET A 641
PHE A 673
GLY A 677
HIS A 721
ALA A 740
 7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
None
7AE  A1000 ( 3.7A)
 0.61A 3cs9D-5td2A:
22.2		 3cs9D-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 565
PHE A 622
GLY A 626
PHE A 668
HIS A 670
ALA A 689
 7YS  A9001 (-3.3A)
7YS  A9001 (-4.3A)
7YS  A9001 (-3.4A)
None
None
7YS  A9001 (-3.4A)
 0.49A 3cs9D-5u6bA:
29.3		 3cs9D-5u6bA:
43.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 ALA A 917
LEU A 946
THR A 963
GLY A 969
HIS A1008
 ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
 0.56A 3cs9D-5wnoA:
27.2		 3cs9D-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 5 ALA A  50
LEU A 101
THR A 118
PHE A 120
HIS A 163
 ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
ADP  A 401 ( 4.2A)
None
 0.53A 3cs9D-5x1tA:
20.2		 3cs9D-5x1tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 LEU A  50
VAL A  83
LEU A  73
ASP A 107
 None
 0.85A 3cs9D-1ag9A:
undetectable		 3cs9D-1ag9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		4 LEU A 263
VAL A 235
LEU A 275
ASP A 280
 None
 0.76A 3cs9D-1fs2A:
undetectable		 3cs9D-1fs2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 158
VAL A 166
LYS A 181
ASP A 275
 None
 0.78A 3cs9D-1gzkA:
20.5		 3cs9D-1gzkA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  70
VAL A  78
LYS A  93
LEU A 193
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
STU  A 401 (-4.7A)
 0.71A 3cs9D-1nxkA:
18.1		 3cs9D-1nxkA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
TYR A 272
VAL A 275
LYS A 290
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 (-4.4A)
 0.72A 3cs9D-1opkA:
33.0		 3cs9D-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A 175
TYR A 178
VAL A 181
LEU A 132
 None
 0.88A 3cs9D-1r5aA:
undetectable		 3cs9D-1r5aA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
LEU A 799
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.78A 3cs9D-1t46A:
33.1		 3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
LYS A 623
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.9A)
 0.88A 3cs9D-1t46A:
33.1		 3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 344
VAL A 352
LYS A 369
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.84A 3cs9D-1u59A:
29.8		 3cs9D-1u59A:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 LEU A  79
VAL A 127
LEU A  64
ASP A 114
 None
 0.81A 3cs9D-1uz4A:
undetectable		 3cs9D-1uz4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		4 LEU B2251
VAL B2223
LEU B2263
ASP B2268
 None
 0.82A 3cs9D-2assB:
undetectable		 3cs9D-2assB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LEU A  19
VAL A  27
LYS A  42
ASP A 156
 None
 0.66A 3cs9D-2bdwA:
20.8		 3cs9D-2bdwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  26
VAL A  34
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.8A)
None
 0.84A 3cs9D-2bujA:
22.3		 3cs9D-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  26
VAL A  34
LYS A  49
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.66A 3cs9D-2bujA:
22.3		 3cs9D-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
VAL A 170
LYS A 186
LEU A 290
 None
 0.77A 3cs9D-2eu9A:
20.5		 3cs9D-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		4 LEU A  49
VAL A  87
LEU A  77
ASP A 111
 None
 0.84A 3cs9D-2fcrA:
undetectable		 3cs9D-2fcrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
VAL A  63
LYS A  78
LEU A 177
 None
 0.71A 3cs9D-2hw6A:
18.6		 3cs9D-2hw6A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
None
 0.68A 3cs9D-2jamA:
17.8		 3cs9D-2jamA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
 0.75A 3cs9D-2jc6A:
15.7		 3cs9D-2jc6A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus) 		PF01115
(F_actin_cap_B)
PF01267
(F-actin_cap_A) 		4 LEU B 310
VAL B 343
LEU A  39
ASP B 327
 None
 0.83A 3cs9D-2kxpB:
undetectable		 3cs9D-2kxpB:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
LEU A 371
ASP A 382
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.97A 3cs9D-2og8A:
26.6		 3cs9D-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 838
LYS A 855
LEU A 971
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.2A)
 0.61A 3cs9D-2p4iA:
23.6		 3cs9D-2p4iA:
37.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 LEU A  25
VAL A  33
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.81A 3cs9D-2phkA:
21.0		 3cs9D-2phkA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
VAL A  60
LYS A  75
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 (-4.9A)
 0.65A 3cs9D-2w4oA:
19.6		 3cs9D-2w4oA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		4 LEU A 540
TYR A 545
VAL A 538
ASP A 567
 None
 0.89A 3cs9D-2wozA:
undetectable		 3cs9D-2wozA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y77 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		4 LEU A  97
VAL A  72
LEU A  86
ASP A  60
 None
None
None
SO4  A1147 ( 4.2A)
 0.90A 3cs9D-2y77A:
undetectable		 3cs9D-2y77A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  68
VAL A  76
LYS A  94
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
 0.58A 3cs9D-2z7rA:
20.7		 3cs9D-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 539
LYS A 553
LEU A 654
ASP A 664
 None
7PE  A   1 (-2.6A)
None
None
 0.78A 3cs9D-2zmcA:
21.7		 3cs9D-2zmcA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 484
VAL A 492
LYS A 514
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-4.6A)
 0.67A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 LEU A 235
VAL A 265
LEU A 166
ASP A 240
 None
 0.87A 3cs9D-3ctzA:
undetectable		 3cs9D-3ctzA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 647
LYS A 665
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.76A 3cs9D-3dkoA:
27.9		 3cs9D-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
LYS A  38
LEU A 173
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 (-4.4A)
 0.38A 3cs9D-3eb0A:
20.6		 3cs9D-3eb0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.8A)
 0.57A 3cs9D-3f2aA:
16.8		 3cs9D-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
VAL A  67
LYS A  82
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
STU  A   1 (-4.4A)
 0.63A 3cs9D-3fmeA:
17.8		 3cs9D-3fmeA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
None
None
 0.95A 3cs9D-3hngA:
31.7		 3cs9D-3hngA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  82
VAL A  90
LYS A 105
LEU A 206
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
 0.60A 3cs9D-3hztA:
17.7		 3cs9D-3hztA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A 141
VAL A 149
LYS A 164
LEU A 267
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
None
 0.84A 3cs9D-3is5A:
17.4		 3cs9D-3is5A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 VAL A  27
LYS A  42
LEU A 142
ASP A 156
 None
 0.87A 3cs9D-3kl8A:
21.7		 3cs9D-3kl8A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  39
VAL A  47
LYS A  62
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
 0.72A 3cs9D-3lm5A:
22.4		 3cs9D-3lm5A:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcs PUTATIVE
MONOOXYGENASE

(Fusobacterium
nucleatum) 		PF03992
(ABM) 		5 LEU A   7
TYR A 150
VAL A  98
LEU A  41
ASP A 213
 None
 1.49A 3cs9D-3mcsA:
undetectable		 3cs9D-3mcsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 171
VAL A 179
LYS A 194
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.2A)
 0.82A 3cs9D-3mtlA:
20.3		 3cs9D-3mtlA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  49
VAL A  57
LYS A  72
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
XFE  A 351 (-4.6A)
 0.77A 3cs9D-3mvjA:
19.6		 3cs9D-3mvjA:
24.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 726
VAL A 734
LYS A 753
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
 0.82A 3cs9D-3pp0A:
24.8		 3cs9D-3pp0A:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 268
TYR A 238
VAL A 270
LEU A 222
ASP A 218
 None
 1.50A 3cs9D-3ppcA:
undetectable		 3cs9D-3ppcA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  63
VAL A  71
LYS A  86
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.4A)
 0.78A 3cs9D-3q5iA:
19.0		 3cs9D-3q5iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
 0.82A 3cs9D-3qkaA:
undetectable		 3cs9D-3qkaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 LEU A  57
VAL A  20
LEU A  96
ASP A  49
 None
 0.84A 3cs9D-3r9qA:
undetectable		 3cs9D-3r9qA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  50
VAL A  58
LYS A  73
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
 0.76A 3cs9D-3sheA:
17.2		 3cs9D-3sheA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 484
VAL A 492
LYS A 514
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 ( 4.4A)
 0.53A 3cs9D-3tt0A:
29.7		 3cs9D-3tt0A:
35.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 361
VAL A 369
LYS A 384
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-4.3A)
 0.80A 3cs9D-3txoA:
16.9		 3cs9D-3txoA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
VAL A 552
LEU A 686
ASP A 697
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.5A)
None
 0.82A 3cs9D-3v5qA:
32.9		 3cs9D-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
VAL A 552
LYS A 572
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
0F4  A 902 (-4.5A)
 0.81A 3cs9D-3v5qA:
32.9		 3cs9D-3v5qA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 402
VAL A 398
LEU A 515
ASP A 510
 None
 0.90A 3cs9D-3vf1A:
undetectable		 3cs9D-3vf1A:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.8A)
None
 0.68A 3cs9D-3vidA:
29.6		 3cs9D-3vidA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 139
VAL A 147
LYS A 162
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.5A)
 0.82A 3cs9D-3w18A:
21.6		 3cs9D-3w18A:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
LYS A 868
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-4.8A)
 0.53A 3cs9D-3wzdA:
30.9		 3cs9D-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 479
LYS A 507
LEU A 622
ASP A 633
 None
 0.79A 3cs9D-3zzwA:
28.0		 3cs9D-3zzwA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 479
VAL A 487
LYS A 507
ASP A 633
 None
 0.89A 3cs9D-3zzwA:
28.0		 3cs9D-3zzwA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
VAL A 568
LYS A 588
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.2A)
 0.74A 3cs9D-4at3A:
33.5		 3cs9D-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  42
VAL A  50
LYS A  65
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.7A)
 0.68A 3cs9D-4bc6A:
20.9		 3cs9D-4bc6A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 LEU A  65
TYR A  68
LEU A  56
ASP A  71
 None
 0.82A 3cs9D-4be3A:
undetectable		 3cs9D-4be3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		4 LEU A 246
VAL A 254
LYS A 269
LEU A 371
 None
 0.70A 3cs9D-4c0tA:
20.4		 3cs9D-4c0tA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  22
VAL A  30
LYS A  45
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
 0.72A 3cs9D-4cfhA:
21.7		 3cs9D-4cfhA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 655
LEU A 773
ASP A 784
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
 0.72A 3cs9D-4ckrA:
31.4		 3cs9D-4ckrA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 855
VAL A 863
LYS A 882
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.7A)
 0.73A 3cs9D-4gl9A:
20.7		 3cs9D-4gl9A:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 828
VAL A 836
LYS A 855
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.5A)
 0.66A 3cs9D-4hviA:
28.7		 3cs9D-4hviA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
VAL A  26
LYS A  41
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
EDO  A 302 (-3.7A)
 0.66A 3cs9D-4jxfA:
19.8		 3cs9D-4jxfA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
VAL A  26
LYS A  41
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.0A)
 0.50A 3cs9D-4jxfA:
19.8		 3cs9D-4jxfA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		4 LEU A  63
VAL A  26
LEU A 106
ASP A  55
 None
 0.86A 3cs9D-4mouA:
undetectable		 3cs9D-4mouA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 603
LYS A 642
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
2TT  A1201 (-4.1A)
 0.89A 3cs9D-4oliA:
26.3		 3cs9D-4oliA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
LYS A 930
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
2TT  A1202 (-4.4A)
 0.85A 3cs9D-4oliA:
26.3		 3cs9D-4oliA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A6345
VAL A6126
LEU A6288
ASP A6122
 None
 0.90A 3cs9D-4opfA:
undetectable		 3cs9D-4opfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 332
VAL A 329
LEU A 288
ASP A 338
 None
 0.82A 3cs9D-4p3zA:
undetectable		 3cs9D-4p3zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
None
EDO  A 303 (-4.0A)
None
 0.81A 3cs9D-4qfeA:
undetectable		 3cs9D-4qfeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  24
VAL A  32
LYS A  47
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.2A)
 0.60A 3cs9D-4rewA:
21.6		 3cs9D-4rewA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.97A 3cs9D-4rt7A:
29.2		 3cs9D-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
VAL A  22
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 ( 4.8A)
None
 0.83A 3cs9D-4ueuA:
31.7		 3cs9D-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 LEU A 104
VAL A 112
LYS A 127
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
ATP  A 501 (-4.5A)
 0.78A 3cs9D-4wb7A:
19.6		 3cs9D-4wb7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A 193
VAL A 201
LYS A 216
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-4.9A)
 0.77A 3cs9D-4wboA:
20.9		 3cs9D-4wboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
VAL A  60
LYS A  74
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
KSA  A 405 (-4.6A)
 0.85A 3cs9D-4wsqA:
21.9		 3cs9D-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 473
VAL A 481
LYS A 503
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
 0.61A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.3A)
None
 0.81A 3cs9D-4xufA:
32.3		 3cs9D-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  34
VAL A  42
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.82A 3cs9D-4ysjA:
21.9		 3cs9D-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
 0.88A 3cs9D-4z0mA:
undetectable		 3cs9D-4z0mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0n ENOYL-COA
HYDRATASE/ISOMERASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU X  57
VAL X  20
LEU X 105
ASP X  49
 None
 0.86A 3cs9D-5e0nX:
undetectable		 3cs9D-5e0nX:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		4 LEU A  99
VAL A 107
LYS A 122
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
None
 0.46A 3cs9D-5eykA:
8.9		 3cs9D-5eykA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
LYS A 930
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.4A)
 0.70A 3cs9D-5f1zA:
23.7		 3cs9D-5f1zA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 607
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.77A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 607
LYS A 627
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.81A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
VAL A  65
LYS A  79
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-4.4A)
 0.88A 3cs9D-5i3oA:
21.7		 3cs9D-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  22
VAL A  30
LYS A  45
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.5A)
 0.70A 3cs9D-5isoA:
21.9		 3cs9D-5isoA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 647
LYS A 665
LEU A 765
ASP A 776
 None
None
6P6  A1001 (-4.5A)
None
 0.85A 3cs9D-5l6oA:
32.7		 3cs9D-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 LEU A 468
VAL A 476
LYS A 491
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
 0.61A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 VAL A 476
LYS A 491
LEU A 599
ASP A 613
 AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.80A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 None
7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
 0.57A 3cs9D-5turA:
20.4		 3cs9D-5turA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 4 LEU A 891
VAL A 899
LYS A 919
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
 0.72A 3cs9D-5wnoA:
27.2		 3cs9D-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 LEU A 778
VAL A 776
LEU A 890
ASP A 770
 None
 0.73A 3cs9D-6ax6A:
undetectable		 3cs9D-6ax6A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 VAL A 539
LYS A 553
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-4.5A)
None
 0.74A 3cs9D-6b4wA:
21.0		 3cs9D-6b4wA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 4 VAL A 701
LYS A 717
LEU A 822
ASP A 834
 919  A1101 (-4.7A)
SO4  A1102 ( 2.8A)
None
919  A1101 (-4.5A)
 0.59A 3cs9D-6cnhA:
20.5		 3cs9D-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 175
LYS A 191
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
 0.87A 3cs9D-6fyvA:
20.5		 3cs9D-6fyvA:
undetectable