SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_C_NILC600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
VAL A 537
 None
 0.89A 3cs9C-1k2pA:
28.9		 3cs9C-1k2pA:
45.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
VAL A 249
ILE A 264
MET A 269
VAL A 330
 None
 0.77A 3cs9C-1k9aA:
27.6		 3cs9C-1k9aA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  70
VAL A  78
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
None
 0.55A 3cs9C-1nxkA:
19.6		 3cs9C-1nxkA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
MET A 337
VAL A 398
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
None
 0.64A 3cs9C-1opkA:
34.2		 3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 TYR A 272
VAL A 275
VAL A 318
ILE A 332
MET A 337
 P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 1.00A 3cs9C-1opkA:
34.2		 3cs9C-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  78
VAL A  86
LYS A 101
VAL A 131
ILE A 145
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
 0.78A 3cs9C-1s9iA:
7.8		 3cs9C-1s9iA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.78A 3cs9C-1zy4A:
20.1		 3cs9C-1zy4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 LEU A 147
VAL A 150
VAL A 132
ILE A 152
VAL A 185
 None
 1.36A 3cs9C-2cuyA:
undetectable		 3cs9C-2cuyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		5 LEU A  65
TYR A 160
VAL A  69
ILE A 168
PHE A  43
 None
 1.43A 3cs9C-2d5rA:
undetectable		 3cs9C-2d5rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daf FLJ35834 PROTEIN

(Homo sapiens) 		PF00240
(ubiquitin) 		5 LEU A  50
VAL A  97
VAL A  20
ILE A  23
VAL A  30
 None
 1.33A 3cs9C-2dafA:
undetectable		 3cs9C-2dafA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
 0.56A 3cs9C-2dq7X:
31.7		 3cs9C-2dq7X:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
VAL X  67
ILE X  80
MET X  85
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
None
None
None
 0.64A 3cs9C-2dq7X:
31.7		 3cs9C-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
LYS A 186
ILE A 234
VAL A 318
 None
 0.76A 3cs9C-2eu9A:
21.2		 3cs9C-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
VAL A 220
ILE A 234
VAL A 318
 None
 0.47A 3cs9C-2eu9A:
21.2		 3cs9C-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
ILE A  91
MET A  96
VAL A 153
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
None
None
None
 0.91A 3cs9C-2f9gA:
14.9		 3cs9C-2f9gA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ILE A 336
MET A 341
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 ( 4.5A)
None
None
 0.74A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.67A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
None
 0.88A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
None
 0.79A 3cs9C-2hckA:
30.1		 3cs9C-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.62A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
VAL A 301
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
None
 0.67A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
VAL A 299
ILE A 313
MET A 318
VAL A 379
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
GIN  A 600 (-4.5A)
 0.67A 3cs9C-2hz0A:
34.7		 3cs9C-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
ILE A 314
PHE A 383
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.3A)
 0.83A 3cs9C-2og8A:
32.6		 3cs9C-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
VAL A 301
ILE A 314
MET A 319
PHE A 383
 None
None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 4.3A)
 0.57A 3cs9C-2og8A:
32.6		 3cs9C-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.78A 3cs9C-2p3gX:
17.7		 3cs9C-2p3gX:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		5 VAL A 156
VAL A 164
ILE A 140
VAL A 180
PHE A 174
 None
 1.32A 3cs9C-2wlcA:
undetectable		 3cs9C-2wlcA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
LYS A 653
ILE A 697
MET A 702
VAL A 762
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
None
 0.47A 3cs9C-2xyuA:
32.3		 3cs9C-2xyuA:
38.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
ILE A 317
MET A 322
VAL A 373
 None
 1.22A 3cs9C-2zv7A:
31.5		 3cs9C-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
ILE A 317
VAL A 373
 None
 1.23A 3cs9C-2zv7A:
31.5		 3cs9C-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
VAL A 303
ILE A 317
 None
 0.78A 3cs9C-2zv7A:
31.5		 3cs9C-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
VAL A 303
ILE A 317
MET A 322
 None
 0.79A 3cs9C-2zv7A:
31.5		 3cs9C-2zv7A:
47.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 LEU A 460
VAL A 456
VAL A 521
ILE A 374
VAL A 517
 None
 1.20A 3cs9C-3ayfA:
undetectable		 3cs9C-3ayfA:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
VAL A 249
ILE A 264
MET A 269
VAL A 330
 None
 0.77A 3cs9C-3d7uA:
31.9		 3cs9C-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
VAL A 695
ILE A 709
MET A 714
VAL A 774
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 4.7A)
IHZ  A1001 (-4.7A)
 0.76A 3cs9C-3dkoA:
31.4		 3cs9C-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
None
None
None
 0.74A 3cs9C-3fmeA:
17.8		 3cs9C-3fmeA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  67
LYS A  82
ILE A 127
MET A 132
VAL A 185
 None
STU  A   1 ( 4.2A)
None
None
None
 1.39A 3cs9C-3fmeA:
17.8		 3cs9C-3fmeA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		5 LEU A1312
VAL A1329
VAL A1449
MET A1363
PHE A1431
 None
 1.34A 3cs9C-3hrrA:
undetectable		 3cs9C-3hrrA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 696
VAL A 704
LYS A 723
VAL A 753
VAL A 831
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
None
 1.10A 3cs9C-3kexA:
24.4		 3cs9C-3kexA:
35.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE

(Streptomyces
avermitilis) 		PF00857
(Isochorismatase) 		5 LEU A 136
TYR A  50
VAL A 133
VAL A  68
PHE A 176
 None
 1.15A 3cs9C-3kl2A:
undetectable		 3cs9C-3kl2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		5 LEU A 173
VAL A  17
VAL A 304
ILE A 294
PHE A 287
 None
 1.05A 3cs9C-3lmaA:
undetectable		 3cs9C-3lmaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  25
LYS A  40
VAL A  72
MET A  93
VAL A 150
 None
 0.80A 3cs9C-3oz6A:
20.9		 3cs9C-3oz6A:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 726
VAL A 734
LYS A 753
MET A 801
VAL A 782
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
None
None
 1.26A 3cs9C-3pp0A:
24.8		 3cs9C-3pp0A:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4f DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		5 LEU C 108
VAL C  22
ILE C   8
VAL C  33
PHE C 111
 None
 0.96A 3cs9C-3q4fC:
undetectable		 3cs9C-3q4fC:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 LEU A 203
VAL A 208
VAL A 104
ILE A 101
VAL A 125
 None
 1.43A 3cs9C-3rrvA:
undetectable		 3cs9C-3rrvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  50
VAL A  58
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
 0.68A 3cs9C-3sheA:
18.9		 3cs9C-3sheA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
LYS A 445
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.93A 3cs9C-3sxsA:
31.8		 3cs9C-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
VAL A 431
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.50A 3cs9C-3sxsA:
31.8		 3cs9C-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 544
VAL A 552
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
None
 0.79A 3cs9C-3v5qA:
31.5		 3cs9C-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 552
LYS A 572
VAL A 601
MET A 620
PHE A 698
 None
0F4  A 902 (-4.0A)
None
None
0F4  A 902 (-4.1A)
 1.10A 3cs9C-3v5qA:
31.5		 3cs9C-3v5qA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
LYS A  82
ILE A 127
MET A 132
VAL A 185
 None
ANK  A 401 (-2.4A)
None
None
None
 1.17A 3cs9C-3vn9A:
21.4		 3cs9C-3vn9A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
MET A 132
 None
ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
None
None
None
 1.13A 3cs9C-3vn9A:
21.4		 3cs9C-3vn9A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.59A 3cs9C-3wigA:
17.2		 3cs9C-3wigA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		5 LEU A 330
VAL A 549
VAL A 543
VAL A 558
PHE A 655
 None
 1.19A 3cs9C-3wrfA:
undetectable		 3cs9C-3wrfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 LEU C 761
VAL C 918
VAL C 914
VAL C 891
PHE C 888
 None
 1.34A 3cs9C-4aq1C:
undetectable		 3cs9C-4aq1C:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
LYS A 588
VAL A 617
MET A 636
 LTI  A1839 ( 4.2A)
None
None
None
None
 0.78A 3cs9C-4at3A:
31.0		 3cs9C-4at3A:
37.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b50 2H10 LLAMA VHH

(Lama glama) 		PF07686
(V-set) 		5 LEU A  47
TYR A  37
VAL A  48
VAL A  78
MET A  34
 None
 1.34A 3cs9C-4b50A:
undetectable		 3cs9C-4b50A:
17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  42
VAL A  50
LYS A  65
VAL A  94
ILE A 108
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
 0.80A 3cs9C-4bc6A:
21.8		 3cs9C-4bc6A:
30.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 655
MET A 704
PHE A 785
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
None
DI1  A1000 (-4.5A)
 0.57A 3cs9C-4ckrA:
30.4		 3cs9C-4ckrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 VAL A  25
LYS A  40
VAL A  72
ILE A  86
VAL A 150
 None
 0.59A 3cs9C-4d28A:
20.6		 3cs9C-4d28A:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1122
VAL A1130
VAL A1180
ILE A1194
MET A1199
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
 0.90A 3cs9C-4fodA:
29.8		 3cs9C-4fodA:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
 924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
 0.75A 3cs9C-4g34A:
20.9		 3cs9C-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		5 LEU B  65
TYR B 160
VAL B  69
ILE B 168
PHE B  43
 None
None
None
None
GOL  B 303 (-2.9A)
 1.46A 3cs9C-4gmjB:
undetectable		 3cs9C-4gmjB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 LEU A  17
VAL A  10
VAL A  56
ILE A  52
VAL A  61
 None
None
None
None
GOL  A 201 ( 4.9A)
 1.16A 3cs9C-4i9yA:
undetectable		 3cs9C-4i9yA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.77A 3cs9C-4idtA:
21.4		 3cs9C-4idtA:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.53A 3cs9C-4k11A:
29.9		 3cs9C-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
VAL A 323
ILE A 336
MET A 341
VAL A 402
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
None
0J9  A 601 (-4.4A)
None
None
 0.91A 3cs9C-4k11A:
29.9		 3cs9C-4k11A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
VAL A  41
LYS A  56
ILE A  97
VAL A  82
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
None
None
 1.00A 3cs9C-4lg4A:
17.8		 3cs9C-4lg4A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
VAL A  41
LYS A  56
VAL A  83
ILE A  97
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
None
 0.77A 3cs9C-4lg4A:
17.8		 3cs9C-4lg4A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.74A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
VAL A 323
ILE A 336
MET A 341
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 0.72A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.9A)
 1.19A 3cs9C-4rt7A:
26.5		 3cs9C-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.72A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
VAL A  65
ILE A  79
MET A  84
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.66A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  40
VAL A  48
LYS A  63
VAL A  92
ILE A 106
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-4.5A)
None
6UI  A 700 (-3.5A)
 1.02A 3cs9C-4usfA:
24.4		 3cs9C-4usfA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
 0.73A 3cs9C-4wsqA:
22.1		 3cs9C-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 290
VAL B 318
ILE B 332
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
 0.83A 3cs9C-4xeyB:
29.2		 3cs9C-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
VAL B 318
ILE B 332
MET B 337
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
None
 0.67A 3cs9C-4xeyB:
29.2		 3cs9C-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
ILE A 472
MET A 477
VAL A 537
 None
 1.21A 3cs9C-4xi2A:
24.8		 3cs9C-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 None
 0.94A 3cs9C-4xi2A:
24.8		 3cs9C-4xi2A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
ILE A 472
MET A 477
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.68A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
None
None
 0.93A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.58A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chx XRCC4-MYH7-1590-1657

(Homo sapiens) 		PF01576
(Myosin_tail_1)
PF06632
(XRCC4) 		5 LEU A 108
VAL A  22
ILE A   8
VAL A  33
PHE A 111
 MLY  A  99 ( 4.5A)
MLY  A   4 ( 4.4A)
None
None
None
 0.97A 3cs9C-5chxA:
undetectable		 3cs9C-5chxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		5 LEU A  71
TYR A  78
VAL A  68
VAL A 214
VAL A 131
 None
 1.35A 3cs9C-5foeA:
undetectable		 3cs9C-5foeA:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
LYS A 627
ILE A 672
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.7A)
 1.22A 3cs9C-5grnA:
27.2		 3cs9C-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 607
LYS A 627
ILE A 672
VAL A 824
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
748  A1001 (-3.7A)
 1.23A 3cs9C-5grnA:
27.2		 3cs9C-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.55A 3cs9C-5i3oA:
22.0		 3cs9C-5i3oA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
LYS A 665
ILE A 709
MET A 714
VAL A 774
 None
None
6P6  A1001 ( 4.5A)
None
DIO  A1002 (-4.9A)
 0.62A 3cs9C-5l6oA:
31.2		 3cs9C-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.66A 3cs9C-5u94A:
19.5		 3cs9C-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.71A 3cs9C-5u94A:
19.5		 3cs9C-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
VAL A  41
LYS A  56
VAL A  83
ILE A  97
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 (-2.4A)
None
None
 0.77A 3cs9C-6ao5A:
22.2		 3cs9C-6ao5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 LEU A 197
VAL A 205
LYS A 219
ILE A 262
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-3.9A)
 0.97A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 LEU A 197
VAL A 205
LYS A 219
ILE A 262
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.7A)
 0.89A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 VAL A 205
LYS A 219
ILE A 262
MET A 267
PHE A 331
 FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-3.9A)
 1.12A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 VAL A 205
LYS A 219
ILE A 262
MET A 267
VAL A 328
 FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-4.7A)
 1.21A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 5 LEU A 138
TYR A 139
VAL A  42
VAL A  10
PHE A   7
 None
None
TRP  A 501 ( 4.6A)
None
TRP  A 501 (-4.9A)
 1.21A 3cs9C-6dfuA:
undetectable		 3cs9C-6dfuA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 LEU A 169
VAL A 177
VAL A 227
ILE A 241
VAL A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
None
None
None
 0.52A 3cs9C-6fylA:
21.5		 3cs9C-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.66A 3cs9C-6fyoA:
21.5		 3cs9C-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.60A 3cs9C-6fyoA:
21.5		 3cs9C-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
 0.59A 3cs9C-6fyvA:
21.4		 3cs9C-6fyvA:
undetectable