SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_C_NILC600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 428
LEU A 457
THR A 474
PHE A 517
HIS A 519
 None
 0.78A 3cs9C-1k2pA:
28.9		 3cs9C-1k2pA:
45.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 220
GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
HIS A 312
 None
 0.63A 3cs9C-1k9aA:
27.6		 3cs9C-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
HIS A 312
ASP A 332
 None
 1.25A 3cs9C-1k9aA:
27.6		 3cs9C-1k9aA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		5 ALA A5969
GLU A5987
MET A5991
LEU A5999
PHE A6018
 None
 0.79A 3cs9C-1koaA:
16.5		 3cs9C-1koaA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
PHE A 720
HIS A 722
ALA A 741
ASP A 742
 None
 0.59A 3cs9C-1lufA:
27.9		 3cs9C-1lufA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ALA A 288
GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
PHE A 336
HIS A 380
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.5A)
 0.68A 3cs9C-1opkA:
34.2		 3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
PHE A 378
 None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
None
 1.37A 3cs9C-1opkA:
34.2		 3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
VAL A 643
THR A 670
HIS A 790
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
 0.47A 3cs9C-1t46A:
26.9		 3cs9C-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
GLU X  54
MET X  58
LEU X  66
THR X  82
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 ( 4.1A)
 0.58A 3cs9C-2dq7X:
31.7		 3cs9C-2dq7X:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
MET X  58
LEU X  66
THR X  82
HIS X 128
ALA X 147
 STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
None
STU  X 902 ( 4.1A)
 0.54A 3cs9C-2dq7X:
31.7		 3cs9C-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
GLU A 201
ILE A 208
HIS A 281
ALA A 319
 None
 0.76A 3cs9C-2eu9A:
21.2		 3cs9C-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
GLU A 201
VAL A 204
ILE A 208
ALA A 319
 None
 0.74A 3cs9C-2eu9A:
21.2		 3cs9C-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		6 ALA A 192
VAL A 179
ILE A 171
LEU A 167
THR A 155
ALA A 165
 None
 1.43A 3cs9C-2g8lA:
undetectable		 3cs9C-2g8lA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LEU A 322
THR A 338
HIS A 384
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
None
H8H  A 534 ( 4.0A)
 0.66A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
THR A 338
PHE A 340
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 ( 4.5A)
 0.74A 3cs9C-2hckA:
30.1		 3cs9C-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
None
ADP  A 400 ( 4.8A)
 1.14A 3cs9C-2henA:
31.6		 3cs9C-2henA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.56A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
HIS A 362
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 ( 3.7A)
 0.78A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
VAL A 291
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.84A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 ALA A 269
GLU A 286
VAL A 289
MET A 290
ILE A 293
LEU A 298
THR A 315
PHE A 317
HIS A 361
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.90A 3cs9C-2hz0A:
34.7		 3cs9C-2hz0A:
98.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
PHE A 542
HIS A 544
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.83A 3cs9C-2j0jA:
31.8		 3cs9C-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
PHE A 542
HIS A 544
ASP A 564
 BII  A1687 (-3.5A)
None
None
None
None
None
 1.00A 3cs9C-2jkmA:
31.9		 3cs9C-2jkmA:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
GLU A 288
MET A 292
LEU A 300
THR A 316
HIS A 362
ALA A 381
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.46A 3cs9C-2og8A:
32.6		 3cs9C-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
MET A 637
THR A 663
HIS A 776
ASP A 796
 None
 0.90A 3cs9C-2ogvA:
29.5		 3cs9C-2ogvA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
PHE A 960
HIS A 962
ALA A 981
ASP A 982
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.7A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.51A 3cs9C-2p4iA:
24.0		 3cs9C-2p4iA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
VAL A 875
HIS A 962
ALA A 981
ASP A 982
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.40A 3cs9C-2p4iA:
24.0		 3cs9C-2p4iA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
GLU A 534
MET A 538
ILE A 541
HIS A 624
ALA A 643
 None
 0.68A 3cs9C-2psqA:
31.2		 3cs9C-2psqA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 215
GLU A 230
LEU A 244
THR A 265
PHE A 267
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
 0.68A 3cs9C-2qluA:
24.3		 3cs9C-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
ILE A 233
THR A 265
PHE A 267
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
None
None
 1.09A 3cs9C-2qluA:
24.3		 3cs9C-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LEU A 244
THR A 265
PHE A 267
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
None
None
 0.57A 3cs9C-2qluA:
24.3		 3cs9C-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 133
GLU A 151
VAL A 154
MET A 155
LEU A 163
HIS A 225
 16X  A1374 ( 3.8A)
None
None
None
None
None
 0.82A 3cs9C-2x4fA:
22.1		 3cs9C-2x4fA:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 273
GLU A 290
MET A 294
LEU A 302
THR A 319
PHE A 321
ASP A 385
 None
 1.10A 3cs9C-2zv7A:
31.5		 3cs9C-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 273
MET A 294
LEU A 302
THR A 319
PHE A 321
HIS A 365
ALA A 384
ASP A 385
 None
 1.05A 3cs9C-2zv7A:
31.5		 3cs9C-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 515
MET A 538
ILE A 541
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
None
 0.64A 3cs9C-3b2tA:
30.4		 3cs9C-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A1108
GLU A1127
MET A1131
PHE A1200
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.8A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.83A 3cs9C-3c1xA:
26.7		 3cs9C-3c1xA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.67A 3cs9C-3c4fA:
30.9		 3cs9C-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 220
GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
HIS A 312
 None
 0.63A 3cs9C-3d7uA:
31.9		 3cs9C-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
HIS A 312
ASP A 332
 None
 1.25A 3cs9C-3d7uA:
31.9		 3cs9C-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
GLU A 682
MET A 686
PHE A 713
HIS A 756
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
 0.74A 3cs9C-3dkoA:
31.4		 3cs9C-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  51
GLU A  71
THR A 106
HIS A 148
ASP A 168
 NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
 0.29A 3cs9C-3gp0A:
22.3		 3cs9C-3gp0A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		6 ALA A 130
VAL A  24
ILE A  16
LEU A  15
THR A 131
PHE A 133
 None
 1.50A 3cs9C-3h3zA:
undetectable		 3cs9C-3h3zA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
GLU A 684
MET A 688
THR A 713
HIS A 758
 None
 0.59A 3cs9C-3kulA:
26.9		 3cs9C-3kulA:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
ILE A 247
THR A 279
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
None
LDN  A   1 ( 3.8A)
 0.88A 3cs9C-3mdyA:
24.7		 3cs9C-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
ILE A 245
THR A 277
HIS A 328
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
LDN  A 600 ( 3.8A)
None
 0.95A 3cs9C-3my0A:
25.0		 3cs9C-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
VAL A 133
MET A 134
HIS A 203
ASP A 223
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
SO4  A   5 ( 4.5A)
 1.05A 3cs9C-3nuuA:
22.6		 3cs9C-3nuuA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
GLU A 596
MET A 600
THR A 625
HIS A 674
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
None
 0.59A 3cs9C-3ppzA:
28.7		 3cs9C-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 217
GLU A 232
VAL A 235
THR A 267
PHE A 269
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
 0.74A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 217
THR A 267
PHE A 269
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
None
TAK  A   2 ( 4.2A)
 0.49A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 217
VAL A 235
THR A 267
PHE A 269
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 ( 4.2A)
 0.60A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  84
GLU A 115
THR A 144
PHE A 146
HIS A 188
 ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.78A 3cs9C-3q5iA:
19.9		 3cs9C-3q5iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  84
LEU A 122
THR A 144
PHE A 146
HIS A 188
 ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.89A 3cs9C-3q5iA:
19.9		 3cs9C-3q5iA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 443
MET A 464
LEU A 472
THR A 489
HIS A 534
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
None
 0.47A 3cs9C-3sxsA:
31.8		 3cs9C-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
None
07J  A   1 (-3.2A)
 0.67A 3cs9C-3tt0A:
30.1		 3cs9C-3tt0A:
35.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 382
GLU A 403
LEU A 416
PHE A 435
ALA A 496
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 ( 4.0A)
 0.86A 3cs9C-3txoA:
18.0		 3cs9C-3txoA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 570
GLU A 588
PHE A 675
HIS A 677
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.2A)
0F4  A 902 (-4.1A)
None
 0.68A 3cs9C-3v5qA:
31.5		 3cs9C-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
PHE A 918
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
None
None
 0.51A 3cs9C-3vidA:
26.3		 3cs9C-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
ILE A 892
PHE A 918
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
None
 0.54A 3cs9C-3wzdA:
26.3		 3cs9C-3wzdA:
38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
GLU A  50
LEU A  62
PHE A  81
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
 0.72A 3cs9C-3zduA:
22.4		 3cs9C-3zduA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.71A 3cs9C-3zfxA:
31.7		 3cs9C-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
ILE A 892
PHE A 918
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
None
 0.64A 3cs9C-4agdA:
30.3		 3cs9C-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
ILE A 892
PHE A 918
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.4A)
None
None
 0.64A 3cs9C-4agdA:
30.3		 3cs9C-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
HIS A 214
 30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
 1.08A 3cs9C-4aw5A:
27.5		 3cs9C-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
GLU A  81
PHE A 112
HIS A 155
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.5A)
None
XZN  A1317 ( 4.3A)
 0.83A 3cs9C-4bc6A:
21.8		 3cs9C-4bc6A:
30.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
ILE A  84
PHE A 112
HIS A 155
ALA A 174
 XZN  A1317 (-3.5A)
None
XZN  A1317 (-4.5A)
None
XZN  A1317 ( 4.3A)
 0.89A 3cs9C-4bc6A:
21.8		 3cs9C-4bc6A:
30.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
GLU A 672
MET A 676
THR A 701
HIS A 764
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.56A 3cs9C-4ckrA:
30.4		 3cs9C-4ckrA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
ILE A 675
LEU A 679
THR A 701
HIS A 764
ASP A 784
 DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.1A)
 1.11A 3cs9C-4ckrA:
30.4		 3cs9C-4ckrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		6 ALA A 150
VAL A 209
ILE A 192
PHE A 188
HIS A 128
ALA A 143
 None
 1.49A 3cs9C-4f0lA:
undetectable		 3cs9C-4f0lA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 538
PHE A 595
PHE A 641
HIS A 643
ALA A 662
 0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
None
None
0T8  A 901 ( 4.5A)
 0.64A 3cs9C-4feqA:
23.6		 3cs9C-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 PHE A 595
PHE A 641
HIS A 643
ALA A 662
ASP A 663
 0T8  A 901 (-3.9A)
None
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.81A 3cs9C-4feqA:
23.6		 3cs9C-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 156
GLU A 177
LEU A 189
THR A 205
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-3.2A)
None
 0.91A 3cs9C-4id7A:
30.4		 3cs9C-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
GLU A 525
MET A 529
ILE A 532
HIS A 615
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
None
 0.86A 3cs9C-4k33A:
26.1		 3cs9C-4k33A:
38.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  54
GLU A  70
MET A  74
HIS A 144
ALA A 163
 GOL  A 404 ( 3.1A)
None
None
None
GOL  A 403 ( 3.0A)
 0.94A 3cs9C-4lg4A:
17.8		 3cs9C-4lg4A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
MET A 314
LEU A 322
HIS A 384
ALA A 403
 VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
None
None
VGG  A 601 ( 4.2A)
 0.68A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
VAL A 313
MET A 314
LEU A 322
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.6A)
None
VGG  A 601 ( 4.2A)
 0.79A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  49
THR A  95
PHE A  97
HIS A 141
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
None
 0.68A 3cs9C-4m69A:
23.9		 3cs9C-4m69A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
GLU B  70
VAL B  73
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 0.92A 3cs9C-4o27B:
24.0		 3cs9C-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 GLU A  94
MET A  98
LEU A 106
THR A 130
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.0A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.67A 3cs9C-4o2zA:
21.1		 3cs9C-4o2zA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  67
GLU A  85
MET A  89
THR A 123
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
None
 0.86A 3cs9C-4o38A:
19.5		 3cs9C-4o38A:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
GLU A  52
MET A  56
LEU A  64
THR A  81
HIS A 127
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
None
 1.22A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
MET A  56
LEU A  64
THR A  81
HIS A 127
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
None
 1.09A 3cs9C-4ueuA:
32.8		 3cs9C-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  72
GLU A  90
MET A  94
PHE A 128
HIS A 174
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
None
ZN  A 403 ( 2.6A)
 1.19A 3cs9C-4wsqA:
22.0		 3cs9C-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
None
40M  A1002 (-3.0A)
 0.63A 3cs9C-4xcuA:
30.8		 3cs9C-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 ALA B 288
VAL B 308
MET B 309
ILE B 312
LEU B 317
THR B 334
PHE B 336
HIS B 380
ALA B 399
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.72A 3cs9C-4xeyB:
29.2		 3cs9C-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 VAL B 308
MET B 309
ILE B 312
LEU B 317
THR B 334
PHE B 378
 None
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-3.3A)
None
 1.48A 3cs9C-4xeyB:
29.2		 3cs9C-4xeyB:
74.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 ALA A 428
LEU A 457
THR A 474
PHE A 517
HIS A 519
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
None
None
 0.72A 3cs9C-4y93A:
30.5		 3cs9C-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 488
GLU A 509
THR A 539
HIS A 586
ALA A 605
 4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
None
4CV  A 801 ( 3.9A)
 0.89A 3cs9C-4yffA:
20.2		 3cs9C-4yffA:
29.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
None
EDO  A1766 ( 4.4A)
 0.68A 3cs9C-5a46A:
30.0		 3cs9C-5a46A:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 275
ILE A 293
THR A 325
HIS A 377
ASP A 397
 STU  A 601 (-3.1A)
None
STU  A 601 ( 3.7A)
None
STU  A 601 (-3.0A)
 0.93A 3cs9C-5e8yA:
8.5		 3cs9C-5e8yA:
27.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
MET A 648
THR A 674
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.60A 3cs9C-5grnA:
27.2		 3cs9C-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
MET A1131
PHE A1200
HIS A1202
ALA A1221
 63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
 0.75A 3cs9C-5horA:
28.9		 3cs9C-5horA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
PHE A1200
HIS A1202
ALA A1221
ASP A1222
 63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.3A)
None
 0.91A 3cs9C-5horA:
28.9		 3cs9C-5horA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
PHE A  92
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
None
6G2  A 901 ( 4.2A)
 0.71A 3cs9C-5j5tA:
21.5		 3cs9C-5j5tA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 743
GLU A 762
VAL A 765
MET A 766
HIS A 835
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.1A)
None
 0.79A 3cs9C-5j9zA:
30.0		 3cs9C-5j9zA:
37.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLU A 315
VAL A 318
MET A 319
HIS A 387
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
None
None
 1.22A 3cs9C-5kbrA:
22.0		 3cs9C-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLU A 315
VAL A 318
MET A 319
LEU A 405
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
None
None
 1.13A 3cs9C-5kbrA:
22.0		 3cs9C-5kbrA:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 663
MET A 686
THR A 711
PHE A 713
HIS A 756
ASP A 776
 6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
DIO  A1002 (-4.1A)
None
 0.62A 3cs9C-5l6oA:
31.2		 3cs9C-5l6oA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 617
MET A 641
PHE A 673
PHE A 719
HIS A 721
ALA A 740
 7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
None
None
7AE  A1000 ( 3.7A)
 0.80A 3cs9C-5td2A:
29.5		 3cs9C-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 565
PHE A 622
PHE A 668
HIS A 670
ALA A 689
 7YS  A9001 (-3.3A)
7YS  A9001 (-4.3A)
None
None
7YS  A9001 (-3.4A)
 0.53A 3cs9C-5u6bA:
26.9		 3cs9C-5u6bA:
43.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 5 ALA A  50
LEU A 101
THR A 118
PHE A 120
HIS A 163
 ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
ADP  A 401 ( 4.2A)
None
 0.59A 3cs9C-5x1tA:
21.1		 3cs9C-5x1tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ALA A  87
GLU A 107
MET A 111
HIS A 180
ALA A 199
 None
 0.87A 3cs9C-6c9dA:
21.0		 3cs9C-6c9dA:
16.13