SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_B_NILB600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
LEU A 528
VAL A 537
 None
 1.04A 3cs9B-1k2pA:
29.0		 3cs9B-1k2pA:
45.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
VAL A 249
ILE A 264
PHE A 310
LEU A 321
VAL A 330
 None
 0.76A 3cs9B-1k9aA:
28.0		 3cs9B-1k9aA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  70
VAL A  78
LYS A  93
ILE A 136
LEU A 193
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
STU  A 401 (-4.7A)
 0.71A 3cs9B-1nxkA:
19.8		 3cs9B-1nxkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  70
VAL A  78
LYS A  93
VAL A 118
ILE A 136
LEU A 141
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
None
STU  A 401 (-3.9A)
 1.18A 3cs9B-1nxkA:
19.8		 3cs9B-1nxkA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
LYS A 290
VAL A 318
ILE A 332
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-4.4A)
 0.73A 3cs9B-1opkA:
34.3		 3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
LEU A 389
VAL A 398
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-4.4A)
None
 0.53A 3cs9B-1opkA:
34.3		 3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
VAL A 318
ILE A 332
PHE A 378
LEU A 389
VAL A 398
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
P16  A   2 (-4.4A)
None
 0.68A 3cs9B-1opkA:
34.3		 3cs9B-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  78
VAL A  86
VAL A 131
ILE A 145
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
ATP  A 535 (-4.8A)
 0.88A 3cs9B-1s9iA:
22.1		 3cs9B-1s9iA:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 377
LYS A 391
VAL A 419
LEU A 489
VAL A 498
 None
 0.82A 3cs9B-1snxA:
31.2		 3cs9B-1snxA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
LYS A 369
VAL A 399
PHE A 457
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-4.5A)
 0.74A 3cs9B-1u59A:
30.7		 3cs9B-1u59A:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.77A 3cs9B-1zy4A:
20.4		 3cs9B-1zy4A:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
LYS X  39
VAL X  67
ILE X  80
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.4A)
 0.69A 3cs9B-2dq7X:
32.0		 3cs9B-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
LYS A 186
VAL A 220
ILE A 234
LEU A 290
 None
 0.81A 3cs9B-2eu9A:
21.7		 3cs9B-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
VAL A 220
ILE A 234
LEU A 290
VAL A 318
 None
 0.63A 3cs9B-2eu9A:
21.7		 3cs9B-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
ILE A  91
LEU A 144
VAL A 153
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
None
ADP  A 500 (-4.3A)
None
 0.84A 3cs9B-2f9gA:
14.9		 3cs9B-2f9gA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.70A 3cs9B-2h8hA:
30.6		 3cs9B-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
None
 0.97A 3cs9B-2h8hA:
30.6		 3cs9B-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
 0.68A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.4A)
 0.82A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.69A 3cs9B-2hk5A:
28.0		 3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
VAL A 301
ILE A 314
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.4A)
 0.80A 3cs9B-2hk5A:
28.0		 3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 256
LYS A 271
VAL A 299
ILE A 313
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
 0.67A 3cs9B-2hz0A:
34.5		 3cs9B-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
VAL A 299
ILE A 313
PHE A 359
LEU A 370
VAL A 379
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.5A)
 0.76A 3cs9B-2hz0A:
34.5		 3cs9B-2hz0A:
98.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 VAL A 436
LYS A 454
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-4.4A)
 0.49A 3cs9B-2j0jA:
32.8		 3cs9B-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
VAL A 301
ILE A 314
LEU A 371
 None
None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.3A)
 0.75A 3cs9B-2og8A:
33.0		 3cs9B-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.74A 3cs9B-2p3gX:
18.2		 3cs9B-2p3gX:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
LYS A 653
ILE A 697
LEU A 753
VAL A 762
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-4.3A)
None
 0.55A 3cs9B-2xyuA:
28.5		 3cs9B-2xyuA:
38.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
VAL A 125
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
 0.59A 3cs9B-2z7rA:
22.1		 3cs9B-2z7rA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
VAL A 303
ILE A 317
 None
 0.85A 3cs9B-2zv7A:
26.7		 3cs9B-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
VAL A 249
ILE A 264
PHE A 310
LEU A 321
VAL A 330
 None
 0.76A 3cs9B-3d7uA:
28.0		 3cs9B-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 647
LYS A 665
VAL A 695
ILE A 709
LEU A 765
VAL A 774
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 ( 4.7A)
 0.65A 3cs9B-3dkoA:
32.4		 3cs9B-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
None
None
STU  A   1 (-4.4A)
 0.66A 3cs9B-3fmeA:
18.2		 3cs9B-3fmeA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 431
VAL A 439
VAL A 487
ILE A 500
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
None
None
AGS  A 999 (-4.5A)
 0.69A 3cs9B-3fzpA:
31.6		 3cs9B-3fzpA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
VAL A 892
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
None
 0.75A 3cs9B-3hngA:
31.1		 3cs9B-3hngA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A 141
VAL A 149
LYS A 164
ILE A 208
LEU A 267
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
None
None
 0.89A 3cs9B-3is5A:
18.3		 3cs9B-3is5A:
27.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 696
VAL A 704
VAL A 753
LEU A 822
VAL A 831
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
None
ANP  A   1 (-4.7A)
None
 0.79A 3cs9B-3kexA:
25.3		 3cs9B-3kexA:
35.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 171
VAL A 179
LYS A 194
VAL A 224
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.85A 3cs9B-3mtlA:
15.2		 3cs9B-3mtlA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  49
VAL A  57
LYS A  72
VAL A 104
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
XFE  A 351 (-4.6A)
 0.73A 3cs9B-3mvjA:
20.9		 3cs9B-3mvjA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  25
LYS A  40
VAL A  72
LEU A 141
VAL A 150
 None
 0.75A 3cs9B-3oz6A:
21.2		 3cs9B-3oz6A:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 565
LYS A 578
VAL A 609
ILE A 623
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.3A)
 0.88A 3cs9B-3ppzA:
29.0		 3cs9B-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  50
VAL A  58
LYS A  73
VAL A  98
ILE A 116
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
None
 0.72A 3cs9B-3sheA:
19.0		 3cs9B-3sheA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
VAL A 431
LYS A 445
VAL A 473
ILE A 487
PHE A 532
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
None
 0.84A 3cs9B-3sxsA:
31.9		 3cs9B-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
VAL A 431
VAL A 473
ILE A 487
PHE A 532
LEU A 543
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
PP2  A   1 (-4.6A)
None
 0.60A 3cs9B-3sxsA:
31.9		 3cs9B-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 544
VAL A 552
LYS A 572
VAL A 601
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.5A)
 0.75A 3cs9B-3v5qA:
28.3		 3cs9B-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.8A)
 0.62A 3cs9B-3vidA:
31.3		 3cs9B-3vidA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
 None
ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
None
None
 0.72A 3cs9B-3vn9A:
22.0		 3cs9B-3vn9A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.57A 3cs9B-3wigA:
10.4		 3cs9B-3wigA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
VAL A 128
ILE A 142
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.86A 3cs9B-3wigA:
10.4		 3cs9B-3wigA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
VAL A 899
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
 0.42A 3cs9B-3wzdA:
32.7		 3cs9B-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1951
VAL A1959
ILE A2024
PHE A2075
LEU A2086
 VGH  A3000 ( 4.4A)
None
None
None
VGH  A3000 (-4.3A)
 0.81A 3cs9B-3zbfA:
26.0		 3cs9B-3zbfA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1951
VAL A1959
LYS A1980
ILE A2024
PHE A2075
 VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
None
 0.93A 3cs9B-3zbfA:
26.0		 3cs9B-3zbfA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
LYS A 588
VAL A 617
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-4.2A)
 0.81A 3cs9B-4at3A:
32.4		 3cs9B-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
LYS A  65
VAL A  94
ILE A 108
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
 0.75A 3cs9B-4bc6A:
22.3		 3cs9B-4bc6A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 663
VAL A 671
LYS A 686
VAL A 721
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
 0.84A 3cs9B-4crsA:
17.0		 3cs9B-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A  25
LYS A  40
VAL A  72
ILE A  86
LEU A 141
VAL A 150
 None
 0.88A 3cs9B-4d28A:
20.6		 3cs9B-4d28A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		5 LEU A 133
VAL A 130
VAL A 221
ILE A 155
LEU A 223
 None
 0.89A 3cs9B-4ee8A:
undetectable		 3cs9B-4ee8A:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 515
VAL A 523
LYS A 543
VAL A 572
LEU A 656
 None
 0.92A 3cs9B-4f0iA:
31.1		 3cs9B-4f0iA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 377
VAL A 385
LYS A 402
VAL A 433
PHE A 490
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 ( 4.8A)
None
None
 0.85A 3cs9B-4f4pA:
30.3		 3cs9B-4f4pA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 377
VAL A 385
VAL A 433
PHE A 490
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
None
None
0SB  A 701 (-4.4A)
 0.75A 3cs9B-4f4pA:
30.3		 3cs9B-4f4pA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
VAL A1180
ILE A1194
PHE A1098
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-4.6A)
 1.48A 3cs9B-4fodA:
30.5		 3cs9B-4fodA:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
 924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
 0.77A 3cs9B-4g34A:
21.4		 3cs9B-4g34A:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
VAL A 863
LYS A 882
VAL A 911
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
 0.60A 3cs9B-4gl9A:
28.4		 3cs9B-4gl9A:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 828
VAL A 836
LYS A 855
VAL A 884
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.5A)
 0.48A 3cs9B-4hviA:
30.1		 3cs9B-4hviA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
LEU A 472
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-4.5A)
 1.42A 3cs9B-4idtA:
22.1		 3cs9B-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
VAL A 414
VAL A 453
ILE A 467
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
None
None
T28  A 701 (-3.9A)
 0.80A 3cs9B-4idtA:
22.1		 3cs9B-4idtA:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.56A 3cs9B-4k11A:
30.3		 3cs9B-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
VAL A 402
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
None
0J9  A 601 (-4.4A)
0J9  A 601 (-4.5A)
None
 0.90A 3cs9B-4k11A:
30.3		 3cs9B-4k11A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
VAL A  41
LYS A  56
VAL A  83
ILE A  97
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
None
 0.80A 3cs9B-4lg4A:
18.0		 3cs9B-4lg4A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.82A 3cs9B-4lggA:
30.7		 3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 (-4.5A)
None
 0.79A 3cs9B-4lggA:
30.7		 3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.80A 3cs9B-4rt7A:
27.3		 3cs9B-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
PHE A 125
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.69A 3cs9B-4ueuA:
32.8		 3cs9B-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
VAL A  65
ILE A  79
PHE A 125
LEU A 136
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.71A 3cs9B-4ueuA:
32.8		 3cs9B-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 LEU A 104
VAL A 112
LYS A 127
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
 0.70A 3cs9B-4wb7A:
20.9		 3cs9B-4wb7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
VAL A 201
LYS A 216
VAL A 248
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-4.9A)
 0.81A 3cs9B-4wboA:
22.1		 3cs9B-4wboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.6A)
 0.71A 3cs9B-4wsqA:
22.7		 3cs9B-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 LEU B 267
VAL B 275
LYS B 290
VAL B 318
ILE B 332
PHE B 378
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
None
 0.81A 3cs9B-4xeyB:
30.5		 3cs9B-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 LEU B 267
VAL B 275
VAL B 318
ILE B 332
PHE B 378
LEU B 389
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
1N1  B 601 (-4.3A)
None
 0.67A 3cs9B-4xeyB:
30.5		 3cs9B-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
VAL A 458
ILE A 472
LEU A 528
VAL A 537
 None
 1.16A 3cs9B-4xi2A:
24.9		 3cs9B-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-4.3A)
 0.61A 3cs9B-4xufA:
31.6		 3cs9B-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
VAL A 458
ILE A 472
LEU A 528
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
746  A 702 (-4.4A)
None
 0.74A 3cs9B-4y93A:
30.8		 3cs9B-4y93A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
VAL A 658
ILE A 672
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.3A)
 0.45A 3cs9B-5grnA:
27.5		 3cs9B-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
 0.62A 3cs9B-5i3oA:
22.5		 3cs9B-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
LYS A  45
VAL A  74
ILE A  88
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
 0.57A 3cs9B-5j5tA:
22.0		 3cs9B-5j5tA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
LYS A 665
ILE A 709
LEU A 765
VAL A 774
 None
None
6P6  A1001 ( 4.5A)
6P6  A1001 (-4.5A)
DIO  A1002 (-4.9A)
 0.74A 3cs9B-5l6oA:
31.8		 3cs9B-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.60A 3cs9B-5u94A:
19.5		 3cs9B-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.65A 3cs9B-5u94A:
19.5		 3cs9B-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 686
VAL A 694
LYS A 709
VAL A 738
ILE A 752
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
None
 0.71A 3cs9B-5vilA:
15.8		 3cs9B-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 686
VAL A 694
VAL A 738
ILE A 752
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.1A)
None
9E1  A1001 (-4.5A)
 0.62A 3cs9B-5vilA:
15.8		 3cs9B-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 LEU A 891
VAL A 899
LYS A 919
ILE A 961
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-4.7A)
 0.67A 3cs9B-5wnoA:
28.6		 3cs9B-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
VAL A  41
LYS A  56
VAL A  83
ILE A  97
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 (-2.4A)
None
None
 0.80A 3cs9B-6ao5A:
22.6		 3cs9B-6ao5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
VAL A  41
VAL A  83
ILE A  97
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
None
None
ANP  A 501 (-4.6A)
 0.82A 3cs9B-6ao5A:
22.6		 3cs9B-6ao5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
VAL A 205
LYS A 219
ILE A 262
LEU A 319
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 ( 4.9A)
FKY  A9001 (-4.7A)
 1.08A 3cs9B-6cz4A:
22.5		 3cs9B-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 LEU A 169
VAL A 177
LYS A 193
ILE A 241
LEU A 297
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
None
None
 0.89A 3cs9B-6fylA:
17.1		 3cs9B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
VAL A 177
VAL A 227
ILE A 241
LEU A 297
VAL A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
None
None
None
None
 0.77A 3cs9B-6fylA:
17.1		 3cs9B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
EAQ  A 501 (-4.9A)
 0.90A 3cs9B-6fyoA:
21.6		 3cs9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
VAL A 225
ILE A 239
LEU A 295
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.9A)
None
 0.75A 3cs9B-6fyoA:
21.6		 3cs9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 244
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
3NG  A 501 (-4.1A)
 1.30A 3cs9B-6fyvA:
21.8		 3cs9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
None
 0.88A 3cs9B-6fyvA:
21.8		 3cs9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
VAL A 225
ILE A 239
LEU A 295
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
None
 0.73A 3cs9B-6fyvA:
21.8		 3cs9B-6fyvA:
undetectable