SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_B_NILB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 220
GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
GLY A 272
None
0.42A 3cs9B-1k9aA:
28.0
3cs9B-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 220
VAL A 239
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
None
0.50A 3cs9B-1k9aA:
28.0
3cs9B-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
10 ALA A 288
GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
0.66A 3cs9B-1opkA:
34.3
3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 621
GLU A 640
GLY A 676
HIS A 790
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
1.01A 3cs9B-1t46A:
32.3
3cs9B-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 621
GLU A 640
VAL A 643
THR A 670
GLY A 676
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.50A 3cs9B-1t46A:
32.3
3cs9B-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA X  37
GLU X  54
MET X  58
LEU X  66
THR X  82
GLY X  88
ALA X 147
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
0.55A 3cs9B-2dq7X:
32.0
3cs9B-2dq7X:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA X  37
MET X  58
LEU X  66
THR X  82
GLY X  88
HIS X 128
ALA X 147
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
STU  X 902 ( 4.1A)
0.53A 3cs9B-2dq7X:
32.0
3cs9B-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 184
GLU A 201
VAL A 204
ILE A 208
ALA A 319
None
0.64A 3cs9B-2eu9A:
21.6
3cs9B-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
0.58A 3cs9B-2h8hA:
30.6
3cs9B-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
THR A 338
GLY A 344
ALA A 403
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
0.46A 3cs9B-2h8hA:
30.6
3cs9B-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
0.42A 3cs9B-2hckA:
30.5
3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
0.51A 3cs9B-2hk5A:
28.0
3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
ALA A 381
1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
0.57A 3cs9B-2hk5A:
28.0
3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 269
GLU A 286
VAL A 289
MET A 290
ILE A 293
LEU A 298
THR A 315
GLY A 321
ALA A 380
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-3.1A)
0.56A 3cs9B-2hz0A:
34.5
3cs9B-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 GLU A 286
MET A 290
LEU A 298
THR A 315
GLY A 321
ALA A 380
ASP A 381
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
0.74A 3cs9B-2hz0A:
34.5
3cs9B-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 298
THR A 315
GLY A 321
HIS A 361
ALA A 380
ASP A 381
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
0.71A 3cs9B-2hz0A:
34.5
3cs9B-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 289
ILE A 293
LEU A 298
THR A 315
GLY A 321
HIS A 361
ALA A 380
None
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
0.76A 3cs9B-2hz0A:
34.5
3cs9B-2hz0A:
98.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
5 ALA A 452
GLU A 471
MET A 475
GLY A 505
HIS A 544
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
0.66A 3cs9B-2j0jA:
32.8
3cs9B-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
5 GLU A 471
MET A 475
GLY A 505
HIS A 544
ASP A 564
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
4ST  A1687 (-4.7A)
0.83A 3cs9B-2j0jA:
32.8
3cs9B-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ALA A 271
GLU A 288
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
ALA A 381
ASP A 382
PHE A 383
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
0.51A 3cs9B-2og8A:
32.8
3cs9B-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 614
GLU A 633
MET A 637
THR A 663
GLY A 669
HIS A 776
ASP A 796
None
0.86A 3cs9B-2ogvA:
30.5
3cs9B-2ogvA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 853
VAL A 875
GLY A 908
HIS A 962
ALA A 981
ASP A 982
PHE A 983
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.8A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
0.45A 3cs9B-2p4iA:
24.3
3cs9B-2p4iA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
None
0.60A 3cs9B-2psqA:
32.4
3cs9B-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
None
0.55A 3cs9B-2psqA:
32.4
3cs9B-2psqA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 215
GLU A 230
LEU A 244
THR A 265
GLY A 271
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
0.62A 3cs9B-2qluA:
25.0
3cs9B-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A 215
LEU A 244
THR A 265
GLY A 271
HIS A 319
ALA A 338
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
0.62A 3cs9B-2qluA:
25.0
3cs9B-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 133
GLU A 151
VAL A 154
MET A 155
LEU A 163
16X  A1374 ( 3.8A)
None
None
None
None
0.54A 3cs9B-2x4fA:
22.8
3cs9B-2x4fA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 133
VAL A 154
MET A 155
LEU A 163
HIS A 225
16X  A1374 ( 3.8A)
None
None
None
None
0.66A 3cs9B-2x4fA:
22.8
3cs9B-2x4fA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  47
GLU A  66
VAL A  69
GLY A 101
ALA A 157
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
0.64A 3cs9B-2xikA:
19.7
3cs9B-2xikA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 ALA A 651
MET A 674
THR A 699
GLY A 705
HIS A 744
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
None
0.48A 3cs9B-2xyuA:
28.5
3cs9B-2xyuA:
38.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 ALA A 651
MET A 674
THR A 699
HIS A 744
ASP A 764
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
None
None
0.74A 3cs9B-2xyuA:
28.5
3cs9B-2xyuA:
38.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A1028
VAL A1050
MET A1051
GLY A1082
HIS A1130
S91  A   1 (-3.2A)
None
None
S91  A   1 (-3.3A)
None
0.57A 3cs9B-2z8cA:
23.4
3cs9B-2z8cA:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 ALA A 273
LEU A 302
THR A 319
GLY A 325
HIS A 365
ALA A 384
None
0.49A 3cs9B-2zv7A:
26.7
3cs9B-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 ALA A 273
MET A 294
LEU A 302
THR A 319
HIS A 365
ALA A 384
None
0.79A 3cs9B-2zv7A:
26.7
3cs9B-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
0.63A 3cs9B-3b2tA:
26.4
3cs9B-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A1108
GLY A1163
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.49A 3cs9B-3c1xA:
30.9
3cs9B-3c1xA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLU A1127
GLY A1163
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.66A 3cs9B-3c1xA:
30.9
3cs9B-3c1xA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 512
GLU A 531
GLY A 567
ALA A 640
PHE A 489
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
0.82A 3cs9B-3c4fA:
31.8
3cs9B-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 512
GLU A 531
GLY A 567
HIS A 621
ALA A 640
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-3.6A)
0.49A 3cs9B-3c4fA:
31.8
3cs9B-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 512
MET A 535
GLY A 567
HIS A 621
ALA A 640
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
0.56A 3cs9B-3c4fA:
31.8
3cs9B-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 220
GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
GLY A 272
None
0.42A 3cs9B-3d7uA:
28.0
3cs9B-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 220
VAL A 239
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
None
0.49A 3cs9B-3d7uA:
28.0
3cs9B-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ALA A 663
GLU A 682
MET A 686
HIS A 756
ASP A 776
PHE A 777
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
0.73A 3cs9B-3dkoA:
32.4
3cs9B-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
5 ALA A 663
GLY A 717
HIS A 756
ASP A 776
PHE A 777
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
0.68A 3cs9B-3dkoA:
32.4
3cs9B-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  51
GLU A  71
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.36A 3cs9B-3gp0A:
22.5
3cs9B-3gp0A:
25.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 859
GLU A 878
GLY A 915
HIS A1020
ASP A1040
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
0.75A 3cs9B-3hngA:
31.1
3cs9B-3hngA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
5 ALA A  80
MET A 104
GLY A 135
HIS A 173
ALA A 192
None
0.68A 3cs9B-3iecA:
22.6
3cs9B-3iecA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
HIS A 758
None
None
None
None
GOL  A 403 (-3.4A)
None
0.67A 3cs9B-3kulA:
32.4
3cs9B-3kulA:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
5 ALA A 229
THR A 279
GLY A 285
HIS A 330
ALA A 349
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 ( 3.8A)
0.41A 3cs9B-3mdyA:
25.5
3cs9B-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 227
THR A 277
GLY A 283
HIS A 328
ALA A 347
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 ( 3.8A)
0.40A 3cs9B-3my0A:
25.0
3cs9B-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
6 ALA A 109
GLU A 130
VAL A 133
MET A 134
GLY A 165
HIS A 203
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
None
0.75A 3cs9B-3nuuA:
22.9
3cs9B-3nuuA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
5 ALA A 576
MET A 600
THR A 625
GLY A 631
HIS A 674
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
0.37A 3cs9B-3ppzA:
29.0
3cs9B-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
5 GLU A 596
MET A 600
THR A 625
GLY A 631
HIS A 674
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
0.55A 3cs9B-3ppzA:
29.0
3cs9B-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 217
THR A 267
GLY A 273
HIS A 320
ALA A 339
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 ( 4.2A)
0.52A 3cs9B-3q4tA:
24.2
3cs9B-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 217
VAL A 235
THR A 267
GLY A 273
ALA A 339
TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
0.53A 3cs9B-3q4tA:
24.2
3cs9B-3q4tA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 443
MET A 464
LEU A 472
THR A 489
GLY A 495
HIS A 534
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
0.41A 3cs9B-3sxsA:
31.9
3cs9B-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
None
07J  A   1 (-3.2A)
0.64A 3cs9B-3tt0A:
30.7
3cs9B-3tt0A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
HIS A 621
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.7A)
None
0.70A 3cs9B-3tt0A:
30.7
3cs9B-3tt0A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 570
GLY A 623
HIS A 677
ASP A 697
PHE A 698
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
0.55A 3cs9B-3v5qA:
28.3
3cs9B-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLU A 588
GLY A 623
HIS A 677
ASP A 697
PHE A 698
0F4  A 902 (-3.6A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
0.62A 3cs9B-3v5qA:
28.3
3cs9B-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
ASP A1046
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
None
None
0.59A 3cs9B-3vidA:
31.3
3cs9B-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
None
0.59A 3cs9B-3wzdA:
32.7
3cs9B-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 3.7A)
None
0.68A 3cs9B-4agdA:
31.2
3cs9B-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 866
ILE A 892
GLY A 922
HIS A1026
ASP A1046
B49  A2000 (-3.5A)
None
B49  A2000 ( 3.7A)
None
None
0.70A 3cs9B-4agdA:
31.2
3cs9B-4agdA:
35.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
5 ALA A 233
THR A 283
GLY A 289
HIS A 334
ALA A 353
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 ( 4.2A)
0.33A 3cs9B-4c02A:
25.2
3cs9B-4c02A:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 653
GLU A 672
MET A 676
THR A 701
GLY A 707
HIS A 764
ALA A 783
ASP A 784
PHE A 785
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
0.76A 3cs9B-4ckrA:
30.7
3cs9B-4ckrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 ALA A 684
GLU A 705
LEU A 720
GLY A 743
ALA A 799
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 ( 4.5A)
0.70A 3cs9B-4crsA:
17.0
3cs9B-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
1G0  A 401 (-3.6A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
0.61A 3cs9B-4id7A:
24.7
3cs9B-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-3.5A)
0.36A 3cs9B-4k11A:
30.3
3cs9B-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 506
GLU A 525
MET A 529
ILE A 532
GLY A 561
ALA A 634
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
None
0.68A 3cs9B-4k33A:
26.8
3cs9B-4k33A:
38.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 506
ILE A 532
GLY A 561
HIS A 615
ALA A 634
ACP  A 801 (-3.3A)
None
ACP  A 801 ( 4.6A)
None
None
0.46A 3cs9B-4k33A:
26.8
3cs9B-4k33A:
38.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
5 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 ( 4.2A)
0.30A 3cs9B-4lggA:
30.7
3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
5 ALA A 293
VAL A 313
LEU A 322
GLY A 344
ALA A 403
VGG  A 601 (-3.5A)
None
None
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
0.68A 3cs9B-4lggA:
30.7
3cs9B-4lggA:
46.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24


(Homo sapiens)
PF00069
(Pkinase)
5 ALA B  51
GLU B  70
GLY B 105
HIS B 142
ALA B 161
ADP  B 500 (-3.3A)
None
None
None
None
0.72A 3cs9B-4o27B:
19.1
3cs9B-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24


(Homo sapiens)
PF00069
(Pkinase)
5 ALA B  51
GLU B  70
VAL B  73
GLY B 105
ALA B 161
ADP  B 500 (-3.3A)
None
None
None
None
0.69A 3cs9B-4o27B:
19.1
3cs9B-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
6 GLU A  94
MET A  98
LEU A 106
THR A 130
HIS A 173
ASP A 193
046  A 401 (-3.7A)
046  A 401 (-3.5A)
046  A 401 ( 4.6A)
046  A 401 (-4.0A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
0.69A 3cs9B-4o2zA:
21.3
3cs9B-4o2zA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
HIS A 171
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
0.82A 3cs9B-4o38A:
20.0
3cs9B-4o38A:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 642
GLU A 661
GLY A 697
HIS A 809
ASP A 829
PHE A 830
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
None
P30  A1001 (-3.9A)
0.84A 3cs9B-4rt7A:
27.3
3cs9B-4rt7A:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 411
HIS A 449
ALA A 468
ASP A 469
PHE A 470
None
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
0.69A 3cs9B-4tptA:
22.6
3cs9B-4tptA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 ALA A  35
ILE A  55
THR A  81
GLY A  87
HIS A 127
ALA A 146
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
1.45A 3cs9B-4ueuA:
32.8
3cs9B-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 ALA A  35
LEU A  64
THR A  81
GLY A  87
HIS A 127
ALA A 146
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
0.42A 3cs9B-4ueuA:
32.8
3cs9B-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  61
GLY A 114
HIS A 153
ALA A 172
ASP A 173
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 ( 4.1A)
None
0.83A 3cs9B-4usfA:
19.7
3cs9B-4usfA:
28.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 501
GLU A 520
MET A 524
GLY A 556
HIS A 610
ALA A 629
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-3.0A)
0.54A 3cs9B-4xcuA:
31.4
3cs9B-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
GLY A 556
HIS A 610
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
None
0.65A 3cs9B-4xcuA:
31.4
3cs9B-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 8 ALA B 288
VAL B 308
MET B 309
ILE B 312
LEU B 317
GLY B 340
HIS B 380
ALA B 399
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
0.68A 3cs9B-4xeyB:
30.5
3cs9B-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 8 ALA B 288
VAL B 308
MET B 309
LEU B 317
THR B 334
GLY B 340
HIS B 380
ALA B 399
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
0.49A 3cs9B-4xeyB:
30.5
3cs9B-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 642
GLU A 661
GLY A 697
HIS A 809
ASP A 829
PHE A 830
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
0.79A 3cs9B-4xufA:
31.6
3cs9B-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
5 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
0.50A 3cs9B-4y93A:
30.8
3cs9B-4y93A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
EDO  A1766 ( 4.4A)
0.51A 3cs9B-5a46A:
30.9
3cs9B-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
None
0.72A 3cs9B-5a46A:
30.9
3cs9B-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
HIS A 816
ASP A 836
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
0.61A 3cs9B-5grnA:
27.5
3cs9B-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  43
GLU A  61
MET A  65
GLY A  96
ALA A 153
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
0.67A 3cs9B-5j5tA:
22.0
3cs9B-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  43
MET A  65
GLY A  96
HIS A 134
ALA A 153
6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
0.60A 3cs9B-5j5tA:
22.0
3cs9B-5j5tA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 743
GLU A 762
VAL A 765
MET A 766
HIS A 835
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.1A)
None
0.67A 3cs9B-5j9zA:
31.0
3cs9B-5j9zA:
37.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 297
GLU A 315
VAL A 318
MET A 319
GLY A 350
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
0.58A 3cs9B-5kbrA:
22.3
3cs9B-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 297
VAL A 318
MET A 319
GLY A 350
HIS A 387
IPW  A 601 (-3.5A)
None
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
None
0.84A 3cs9B-5kbrA:
22.3
3cs9B-5kbrA:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 663
MET A 686
THR A 711
HIS A 756
ASP A 776
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
DIO  A1002 (-4.1A)
None
0.55A 3cs9B-5l6oA:
31.8
3cs9B-5l6oA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 617
MET A 641
GLY A 677
HIS A 721
ALA A 740
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
None
7AE  A1000 ( 3.7A)
0.60A 3cs9B-5td2A:
30.3
3cs9B-5td2A:
42.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG


(Homo sapiens)
no annotation 5 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
0.58A 3cs9B-6cnhA:
21.9
3cs9B-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 5 ALA A 217
THR A 264
GLY A 270
HIS A 310
ASP A 330
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
None
0.68A 3cs9B-6cz4A:
22.5
3cs9B-6cz4A:
18.18