SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_B_NILB600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | ALA A 220GLU A 236VAL A 239MET A 240LEU A 248THR A 266GLY A 272 | None | 0.42A | 3cs9B-1k9aA:28.0 | 3cs9B-1k9aA:31.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | ALA A 220VAL A 239MET A 240LEU A 248THR A 266GLY A 272HIS A 312 | None | 0.50A | 3cs9B-1k9aA:28.0 | 3cs9B-1k9aA:31.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 10 | ALA A 288GLU A 305VAL A 308MET A 309ILE A 312LEU A 317THR A 334GLY A 340HIS A 380ALA A 399 | P16 A 2 (-3.4A)P16 A 2 (-4.2A)NoneP16 A 2 (-3.3A)NoneNoneP16 A 2 (-3.7A)P16 A 2 (-3.4A)NoneP16 A 2 (-3.5A) | 0.66A | 3cs9B-1opkA:34.3 | 3cs9B-1opkA:57.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 621GLU A 640GLY A 676HIS A 790ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 1.01A | 3cs9B-1t46A:32.3 | 3cs9B-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 621GLU A 640VAL A 643THR A 670GLY A 676HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.50A | 3cs9B-1t46A:32.3 | 3cs9B-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA X 37GLU X 54MET X 58LEU X 66THR X 82GLY X 88ALA X 147 | STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneNoneSTU X 902 (-4.1A)STU X 902 (-3.5A)STU X 902 ( 4.1A) | 0.55A | 3cs9B-2dq7X:32.0 | 3cs9B-2dq7X:45.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA X 37MET X 58LEU X 66THR X 82GLY X 88HIS X 128ALA X 147 | STU X 902 (-3.1A)NoneNoneSTU X 902 (-4.1A)STU X 902 (-3.5A)NoneSTU X 902 ( 4.1A) | 0.53A | 3cs9B-2dq7X:32.0 | 3cs9B-2dq7X:45.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eu9 | DUAL SPECIFICITYPROTEIN KINASE CLK3 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 184GLU A 201VAL A 204ILE A 208ALA A 319 | None | 0.64A | 3cs9B-2eu9A:21.6 | 3cs9B-2eu9A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322GLY A 344HIS A 384ALA A 403 | H8H A 534 (-3.2A)NoneH8H A 534 (-3.3A)NoneH8H A 534 ( 4.0A) | 0.58A | 3cs9B-2h8hA:30.6 | 3cs9B-2h8hA:27.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322THR A 338GLY A 344ALA A 403 | H8H A 534 (-3.2A)NoneH8H A 534 (-3.1A)H8H A 534 (-3.3A)H8H A 534 ( 4.0A) | 0.46A | 3cs9B-2h8hA:30.6 | 3cs9B-2h8hA:27.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322GLY A 344HIS A 384ALA A 403 | QUE A 1 (-3.5A)NoneQUE A 1 (-3.0A)NoneQUE A 1 ( 4.5A) | 0.42A | 3cs9B-2hckA:30.5 | 3cs9B-2hckA:30.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 271GLU A 288VAL A 291MET A 292LEU A 300THR A 316 | 1BM A 499 (-3.6A)1BM A 499 (-3.2A)None1BM A 499 ( 3.8A)None1BM A 499 (-3.2A) | 0.51A | 3cs9B-2hk5A:28.0 | 3cs9B-2hk5A:48.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 271VAL A 291MET A 292LEU A 300THR A 316GLY A 322HIS A 362ALA A 381 | 1BM A 499 (-3.6A)None1BM A 499 ( 3.8A)None1BM A 499 (-3.2A)1BM A 499 (-3.5A)None1BM A 499 ( 3.7A) | 0.57A | 3cs9B-2hk5A:28.0 | 3cs9B-2hk5A:48.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | ALA A 269GLU A 286VAL A 289MET A 290ILE A 293LEU A 298THR A 315GLY A 321ALA A 380 | GIN A 600 (-3.1A)GIN A 600 (-3.6A)NoneGIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-3.4A)NoneGIN A 600 (-3.1A) | 0.56A | 3cs9B-2hz0A:34.5 | 3cs9B-2hz0A:98.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | GLU A 286MET A 290LEU A 298THR A 315GLY A 321ALA A 380ASP A 381 | GIN A 600 (-3.6A)GIN A 600 (-3.2A)GIN A 600 (-4.2A)GIN A 600 (-3.4A)NoneGIN A 600 (-3.1A)GIN A 600 (-4.9A) | 0.74A | 3cs9B-2hz0A:34.5 | 3cs9B-2hz0A:98.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 298THR A 315GLY A 321HIS A 361ALA A 380ASP A 381 | GIN A 600 (-4.2A)GIN A 600 (-3.4A)NoneGIN A 600 (-4.3A)GIN A 600 (-3.1A)GIN A 600 (-4.9A) | 0.71A | 3cs9B-2hz0A:34.5 | 3cs9B-2hz0A:98.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 289ILE A 293LEU A 298THR A 315GLY A 321HIS A 361ALA A 380 | NoneGIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-3.4A)NoneGIN A 600 (-4.3A)GIN A 600 (-3.1A) | 0.76A | 3cs9B-2hz0A:34.5 | 3cs9B-2hz0A:98.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 5 | ALA A 452GLU A 471MET A 475GLY A 505HIS A 544 | 4ST A1687 (-3.3A)4ST A1687 ( 4.6A)None4ST A1687 (-3.2A)None | 0.66A | 3cs9B-2j0jA:32.8 | 3cs9B-2j0jA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 5 | GLU A 471MET A 475GLY A 505HIS A 544ASP A 564 | 4ST A1687 ( 4.6A)None4ST A1687 (-3.2A)None4ST A1687 (-4.7A) | 0.83A | 3cs9B-2j0jA:32.8 | 3cs9B-2j0jA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ALA A 271GLU A 288MET A 292LEU A 300THR A 316GLY A 322HIS A 362ALA A 381ASP A 382PHE A 383 | 1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.9A)1N8 A 501 ( 3.3A)1N8 A 501 ( 3.5A)None1N8 A 501 ( 3.3A)1N8 A 501 ( 3.3A)1N8 A 501 ( 4.3A) | 0.51A | 3cs9B-2og8A:32.8 | 3cs9B-2og8A:47.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 614GLU A 633MET A 637THR A 663GLY A 669HIS A 776ASP A 796 | None | 0.86A | 3cs9B-2ogvA:30.5 | 3cs9B-2ogvA:38.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p4i | ANGIOPOIETIN-1RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 853VAL A 875GLY A 908HIS A 962ALA A 981ASP A 982PHE A 983 | MR9 A 301 (-3.5A)MR9 A 301 ( 4.8A)MR9 A 301 ( 3.8A)MR9 A 301 (-4.5A)MR9 A 301 (-3.2A)MR9 A 301 (-4.2A)MR9 A 301 (-4.4A) | 0.45A | 3cs9B-2p4iA:24.3 | 3cs9B-2p4iA:37.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 515GLU A 534MET A 538ILE A 541GLY A 570ALA A 643 | None | 0.60A | 3cs9B-2psqA:32.4 | 3cs9B-2psqA:35.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 515MET A 538ILE A 541GLY A 570HIS A 624ALA A 643 | None | 0.55A | 3cs9B-2psqA:32.4 | 3cs9B-2psqA:35.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 215GLU A 230LEU A 244THR A 265GLY A 271 | ADE A 488 (-3.2A)NoneNoneADE A 488 (-4.3A)ADE A 488 ( 4.1A) | 0.62A | 3cs9B-2qluA:25.0 | 3cs9B-2qluA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 215LEU A 244THR A 265GLY A 271HIS A 319ALA A 338 | ADE A 488 (-3.2A)NoneADE A 488 (-4.3A)ADE A 488 ( 4.1A)NoneNone | 0.62A | 3cs9B-2qluA:25.0 | 3cs9B-2qluA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4f | MYOSIN LIGHT CHAINKINASE FAMILY MEMBER4 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 133GLU A 151VAL A 154MET A 155LEU A 163 | 16X A1374 ( 3.8A)NoneNoneNoneNone | 0.54A | 3cs9B-2x4fA:22.8 | 3cs9B-2x4fA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4f | MYOSIN LIGHT CHAINKINASE FAMILY MEMBER4 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 133VAL A 154MET A 155LEU A 163HIS A 225 | 16X A1374 ( 3.8A)NoneNoneNoneNone | 0.66A | 3cs9B-2x4fA:22.8 | 3cs9B-2x4fA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 47GLU A 66VAL A 69GLY A 101ALA A 157 | J60 A1294 (-3.3A)NoneNoneJ60 A1294 ( 3.8A)J60 A1294 ( 4.2A) | 0.64A | 3cs9B-2xikA:19.7 | 3cs9B-2xikA:27.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | ALA A 651MET A 674THR A 699GLY A 705HIS A 744 | Q9G A1898 (-3.2A)Q9G A1898 (-3.9A)Q9G A1898 (-3.5A)Q9G A1898 ( 3.8A)None | 0.48A | 3cs9B-2xyuA:28.5 | 3cs9B-2xyuA:38.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | ALA A 651MET A 674THR A 699HIS A 744ASP A 764 | Q9G A1898 (-3.2A)Q9G A1898 (-3.9A)Q9G A1898 (-3.5A)NoneNone | 0.74A | 3cs9B-2xyuA:28.5 | 3cs9B-2xyuA:38.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2z8c | INSULIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A1028VAL A1050MET A1051GLY A1082HIS A1130 | S91 A 1 (-3.2A)NoneNoneS91 A 1 (-3.3A)None | 0.57A | 3cs9B-2z8cA:23.4 | 3cs9B-2z8cA:40.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 273LEU A 302THR A 319GLY A 325HIS A 365ALA A 384 | None | 0.49A | 3cs9B-2zv7A:26.7 | 3cs9B-2zv7A:47.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 273MET A 294LEU A 302THR A 319HIS A 365ALA A 384 | None | 0.79A | 3cs9B-2zv7A:26.7 | 3cs9B-2zv7A:47.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 515MET A 538ILE A 541GLY A 570HIS A 624ALA A 643 | M33 A1996 (-3.3A)NoneNoneM33 A1996 ( 4.8A)NoneNone | 0.63A | 3cs9B-3b2tA:26.4 | 3cs9B-3b2tA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A1108GLY A1163HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 ( 4.5A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.49A | 3cs9B-3c1xA:30.9 | 3cs9B-3c1xA:33.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLU A1127GLY A1163HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.66A | 3cs9B-3c1xA:30.9 | 3cs9B-3c1xA:33.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 512GLU A 531GLY A 567ALA A 640PHE A 489 | C4F A 1 (-3.3A)NoneNoneC4F A 1 (-3.6A)C4F A 1 (-3.7A) | 0.82A | 3cs9B-3c4fA:31.8 | 3cs9B-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 512GLU A 531GLY A 567HIS A 621ALA A 640 | C4F A 1 (-3.3A)NoneNoneNoneC4F A 1 (-3.6A) | 0.49A | 3cs9B-3c4fA:31.8 | 3cs9B-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 512MET A 535GLY A 567HIS A 621ALA A 640 | C4F A 1 (-3.3A)C4F A 1 ( 3.7A)NoneNoneC4F A 1 (-3.6A) | 0.56A | 3cs9B-3c4fA:31.8 | 3cs9B-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 220GLU A 236VAL A 239MET A 240LEU A 248THR A 266GLY A 272 | None | 0.42A | 3cs9B-3d7uA:28.0 | 3cs9B-3d7uA:44.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 220VAL A 239MET A 240LEU A 248THR A 266GLY A 272HIS A 312 | None | 0.49A | 3cs9B-3d7uA:28.0 | 3cs9B-3d7uA:44.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dko | EPHRIN TYPE-ARECEPTOR 7 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 6 | ALA A 663GLU A 682MET A 686HIS A 756ASP A 776PHE A 777 | IHZ A1001 (-3.3A)IHZ A1001 (-3.8A)IHZ A1001 (-3.5A)IHZ A1001 ( 4.9A)IHZ A1001 (-4.8A)IHZ A1001 (-4.7A) | 0.73A | 3cs9B-3dkoA:32.4 | 3cs9B-3dkoA:36.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dko | EPHRIN TYPE-ARECEPTOR 7 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 5 | ALA A 663GLY A 717HIS A 756ASP A 776PHE A 777 | IHZ A1001 (-3.3A)IHZ A1001 ( 3.9A)IHZ A1001 ( 4.9A)IHZ A1001 (-4.8A)IHZ A1001 (-4.7A) | 0.68A | 3cs9B-3dkoA:32.4 | 3cs9B-3dkoA:36.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gp0 | MITOGEN-ACTIVATEDPROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 51GLU A 71THR A 106HIS A 148ASP A 168 | NIL A 1 (-3.7A)NIL A 1 (-3.7A)NIL A 1 (-3.3A)NIL A 1 (-4.3A)NIL A 1 (-4.6A) | 0.36A | 3cs9B-3gp0A:22.5 | 3cs9B-3gp0A:25.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 859GLU A 878GLY A 915HIS A1020ASP A1040 | 8ST A2001 ( 3.8A)8ST A2001 (-3.7A)None8ST A2001 ( 4.8A)None | 0.75A | 3cs9B-3hngA:31.1 | 3cs9B-3hngA:33.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 5 | ALA A 80MET A 104GLY A 135HIS A 173ALA A 192 | None | 0.68A | 3cs9B-3iecA:22.6 | 3cs9B-3iecA:25.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 6 | ALA A 665GLU A 684MET A 688THR A 713GLY A 719HIS A 758 | NoneNoneNoneNoneGOL A 403 (-3.4A)None | 0.67A | 3cs9B-3kulA:32.4 | 3cs9B-3kulA:35.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 5 | ALA A 229THR A 279GLY A 285HIS A 330ALA A 349 | LDN A 1 (-3.6A)LDN A 1 (-3.8A)LDN A 1 (-3.3A)NoneLDN A 1 ( 3.8A) | 0.41A | 3cs9B-3mdyA:25.5 | 3cs9B-3mdyA:28.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 227THR A 277GLY A 283HIS A 328ALA A 347 | LDN A 600 (-3.2A)LDN A 600 (-4.0A)LDN A 600 (-3.3A)NoneLDN A 600 ( 3.8A) | 0.40A | 3cs9B-3my0A:25.0 | 3cs9B-3my0A:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 109GLU A 130VAL A 133MET A 134GLY A 165HIS A 203 | JOZ A 361 (-3.4A)SO4 A 5 (-3.1A)NoneNoneNoneNone | 0.75A | 3cs9B-3nuuA:22.9 | 3cs9B-3nuuA:25.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | ALA A 576MET A 600THR A 625GLY A 631HIS A 674 | STU A 1 (-3.3A)NoneSTU A 1 (-4.1A)STU A 1 (-3.2A)None | 0.37A | 3cs9B-3ppzA:29.0 | 3cs9B-3ppzA:35.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | GLU A 596MET A 600THR A 625GLY A 631HIS A 674 | NoneNoneSTU A 1 (-4.1A)STU A 1 (-3.2A)None | 0.55A | 3cs9B-3ppzA:29.0 | 3cs9B-3ppzA:35.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 217THR A 267GLY A 273HIS A 320ALA A 339 | TAK A 2 (-3.5A)TAK A 2 (-3.5A)TAK A 2 (-3.6A)NoneTAK A 2 ( 4.2A) | 0.52A | 3cs9B-3q4tA:24.2 | 3cs9B-3q4tA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 217VAL A 235THR A 267GLY A 273ALA A 339 | TAK A 2 (-3.5A)EDO A 489 ( 4.8A)TAK A 2 (-3.5A)TAK A 2 (-3.6A)TAK A 2 ( 4.2A) | 0.53A | 3cs9B-3q4tA:24.2 | 3cs9B-3q4tA:25.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 443MET A 464LEU A 472THR A 489GLY A 495HIS A 534 | PP2 A 1 (-3.2A)PP2 A 1 ( 4.3A)NonePP2 A 1 (-3.3A)PP2 A 1 ( 4.2A)None | 0.41A | 3cs9B-3sxsA:31.9 | 3cs9B-3sxsA:41.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531MET A 535GLY A 567HIS A 621ALA A 640 | 07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)07J A 1 (-3.7A)None07J A 1 (-3.2A) | 0.64A | 3cs9B-3tt0A:30.7 | 3cs9B-3tt0A:35.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531MET A 535ILE A 538GLY A 567HIS A 621 | 07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)None07J A 1 (-3.7A)None | 0.70A | 3cs9B-3tt0A:30.7 | 3cs9B-3tt0A:35.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 570GLY A 623HIS A 677ASP A 697PHE A 698 | 0F4 A 902 (-3.2A)0F4 A 902 (-3.4A)0F4 A 902 (-4.1A)None0F4 A 902 (-4.1A) | 0.55A | 3cs9B-3v5qA:28.3 | 3cs9B-3v5qA:37.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLU A 588GLY A 623HIS A 677ASP A 697PHE A 698 | 0F4 A 902 (-3.6A)0F4 A 902 (-3.4A)0F4 A 902 (-4.1A)None0F4 A 902 (-4.1A) | 0.62A | 3cs9B-3v5qA:28.3 | 3cs9B-3v5qA:37.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 866GLU A 885ILE A 892GLY A 922HIS A1026ASP A1046 | 4TT A2001 (-3.5A)NoneNone4TT A2001 (-3.7A)NoneNone | 0.59A | 3cs9B-3vidA:31.3 | 3cs9B-3vidA:34.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 866GLU A 885ILE A 892GLY A 922HIS A1026 | LEV A1201 (-3.5A)LEV A1201 (-3.7A)NoneLEV A1201 (-3.6A)None | 0.59A | 3cs9B-3wzdA:32.7 | 3cs9B-3wzdA:38.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 866GLU A 885ILE A 892GLY A 922HIS A1026 | B49 A2000 (-3.5A)NoneNoneB49 A2000 ( 3.7A)None | 0.68A | 3cs9B-4agdA:31.2 | 3cs9B-4agdA:35.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 866ILE A 892GLY A 922HIS A1026ASP A1046 | B49 A2000 (-3.5A)NoneB49 A2000 ( 3.7A)NoneNone | 0.70A | 3cs9B-4agdA:31.2 | 3cs9B-4agdA:35.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 5 | ALA A 233THR A 283GLY A 289HIS A 334ALA A 353 | TAK A1507 (-3.3A)TAK A1507 (-3.6A)TAK A1507 (-3.5A)NoneTAK A1507 ( 4.2A) | 0.33A | 3cs9B-4c02A:25.2 | 3cs9B-4c02A:28.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | ALA A 653GLU A 672MET A 676THR A 701GLY A 707HIS A 764ALA A 783ASP A 784PHE A 785 | DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-3.6A)NoneDI1 A1000 (-3.8A)DI1 A1000 (-3.7A)DI1 A1000 (-4.1A)DI1 A1000 (-4.5A) | 0.76A | 3cs9B-4ckrA:30.7 | 3cs9B-4ckrA:37.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | ALA A 684GLU A 705LEU A 720GLY A 743ALA A 799 | AGS A1985 (-3.5A)NoneNoneNoneAGS A1985 ( 4.5A) | 0.70A | 3cs9B-4crsA:17.0 | 3cs9B-4crsA:26.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 156LEU A 189THR A 205GLY A 211HIS A 250 | 1G0 A 401 (-3.6A)None1G0 A 401 (-3.2A)1G0 A 401 ( 4.5A)None | 0.61A | 3cs9B-4id7A:24.7 | 3cs9B-4id7A:39.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322GLY A 344HIS A 384ALA A 403 | 0J9 A 601 (-3.3A)None0J9 A 601 ( 4.1A)None0J9 A 601 (-3.5A) | 0.36A | 3cs9B-4k11A:30.3 | 3cs9B-4k11A:33.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 506GLU A 525MET A 529ILE A 532GLY A 561ALA A 634 | ACP A 801 (-3.3A)ACP A 801 ( 4.8A)NoneNoneACP A 801 ( 4.6A)None | 0.68A | 3cs9B-4k33A:26.8 | 3cs9B-4k33A:38.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 506ILE A 532GLY A 561HIS A 615ALA A 634 | ACP A 801 (-3.3A)NoneACP A 801 ( 4.6A)NoneNone | 0.46A | 3cs9B-4k33A:26.8 | 3cs9B-4k33A:38.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 5 | ALA A 293LEU A 322GLY A 344HIS A 384ALA A 403 | VGG A 601 (-3.5A)NoneVGG A 601 ( 3.2A)NoneVGG A 601 ( 4.2A) | 0.30A | 3cs9B-4lggA:30.7 | 3cs9B-4lggA:46.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 5 | ALA A 293VAL A 313LEU A 322GLY A 344ALA A 403 | VGG A 601 (-3.5A)NoneNoneVGG A 601 ( 3.2A)VGG A 601 ( 4.2A) | 0.68A | 3cs9B-4lggA:30.7 | 3cs9B-4lggA:46.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA B 51GLU B 70GLY B 105HIS B 142ALA B 161 | ADP B 500 (-3.3A)NoneNoneNoneNone | 0.72A | 3cs9B-4o27B:19.1 | 3cs9B-4o27B:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA B 51GLU B 70VAL B 73GLY B 105ALA B 161 | ADP B 500 (-3.3A)NoneNoneNoneNone | 0.69A | 3cs9B-4o27B:19.1 | 3cs9B-4o27B:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o2z | MITOGEN-ACTIVATEDPROTEIN KINASE 3,PUTATIVE (Leishmaniadonovani) |
PF00069(Pkinase) | 6 | GLU A 94MET A 98LEU A 106THR A 130HIS A 173ASP A 193 | 046 A 401 (-3.7A)046 A 401 (-3.5A)046 A 401 ( 4.6A)046 A 401 (-4.0A)046 A 401 (-4.1A)046 A 401 (-4.3A) | 0.69A | 3cs9B-4o2zA:21.3 | 3cs9B-4o2zA:26.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 67GLU A 85MET A 89THR A 123GLY A 128HIS A 171 | SIN A 401 ( 3.7A)NoneNoneNoneSIN A 401 (-3.5A)None | 0.82A | 3cs9B-4o38A:20.0 | 3cs9B-4o38A:25.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 642GLU A 661GLY A 697HIS A 809ASP A 829PHE A 830 | P30 A1001 (-3.4A)P30 A1001 (-3.6A)P30 A1001 (-3.4A)P30 A1001 ( 4.3A)NoneP30 A1001 (-3.9A) | 0.84A | 3cs9B-4rt7A:27.3 | 3cs9B-4rt7A:32.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tpt | LIM DOMAIN KINASE 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLY A 411HIS A 449ALA A 468ASP A 469PHE A 470 | None35H A 701 ( 4.4A)35H A 701 (-3.5A)35H A 701 (-4.7A)35H A 701 (-4.4A) | 0.69A | 3cs9B-4tptA:22.6 | 3cs9B-4tptA:28.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | ALA A 35ILE A 55THR A 81GLY A 87HIS A 127ALA A 146 | ACP A1264 (-2.9A)NoneACP A1264 (-4.5A)ACP A1264 (-3.5A)NoneNone | 1.45A | 3cs9B-4ueuA:32.8 | 3cs9B-4ueuA:65.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | ALA A 35LEU A 64THR A 81GLY A 87HIS A 127ALA A 146 | ACP A1264 (-2.9A)NoneACP A1264 (-4.5A)ACP A1264 (-3.5A)NoneNone | 0.42A | 3cs9B-4ueuA:32.8 | 3cs9B-4ueuA:65.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usf | STE20-LIKESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 61GLY A 114HIS A 153ALA A 172ASP A 173 | 6UI A 700 (-3.3A)6UI A 700 ( 4.2A)None6UI A 700 ( 4.1A)None | 0.83A | 3cs9B-4usfA:19.7 | 3cs9B-4usfA:28.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 501GLU A 520MET A 524GLY A 556HIS A 610ALA A 629 | 40M A1002 ( 4.1A)40M A1002 (-3.7A)40M A1002 (-3.8A)40M A1002 ( 3.7A)None40M A1002 (-3.0A) | 0.54A | 3cs9B-4xcuA:31.4 | 3cs9B-4xcuA:39.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 501GLU A 520VAL A 523MET A 524ILE A 527GLY A 556HIS A 610 | 40M A1002 ( 4.1A)40M A1002 (-3.7A)None40M A1002 (-3.8A)None40M A1002 ( 3.7A)None | 0.65A | 3cs9B-4xcuA:31.4 | 3cs9B-4xcuA:39.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 8 | ALA B 288VAL B 308MET B 309ILE B 312LEU B 317GLY B 340HIS B 380ALA B 399 | 1N1 B 601 (-3.5A)None1N1 B 601 (-3.7A)NoneNone1N1 B 601 (-3.5A)None1N1 B 601 (-3.5A) | 0.68A | 3cs9B-4xeyB:30.5 | 3cs9B-4xeyB:74.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 8 | ALA B 288VAL B 308MET B 309LEU B 317THR B 334GLY B 340HIS B 380ALA B 399 | 1N1 B 601 (-3.5A)None1N1 B 601 (-3.7A)None1N1 B 601 (-3.3A)1N1 B 601 (-3.5A)None1N1 B 601 (-3.5A) | 0.49A | 3cs9B-4xeyB:30.5 | 3cs9B-4xeyB:74.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 642GLU A 661GLY A 697HIS A 809ASP A 829PHE A 830 | P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 (-3.5A)P30 A1001 (-4.4A)NoneP30 A1001 ( 4.1A) | 0.79A | 3cs9B-4xufA:31.6 | 3cs9B-4xufA:38.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 5 | ALA A 428LEU A 457THR A 474GLY A 480HIS A 519 | 746 A 702 (-2.4A)None746 A 702 (-3.7A)746 A 702 (-3.6A)None | 0.50A | 3cs9B-4y93A:30.8 | 3cs9B-4y93A:28.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531MET A 535GLY A 567HIS A 621ALA A 640 | 38O A1769 (-3.6A)EDO A1766 (-4.1A)EDO A1766 (-3.5A)38O A1769 (-3.4A)NoneEDO A1766 ( 4.4A) | 0.51A | 3cs9B-5a46A:30.9 | 3cs9B-5a46A:38.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 512GLU A 531MET A 535ILE A 538HIS A 621 | 38O A1769 (-3.6A)EDO A1766 (-4.1A)EDO A1766 (-3.5A)NoneNone | 0.72A | 3cs9B-5a46A:30.9 | 3cs9B-5a46A:38.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 625GLU A 644MET A 648THR A 674GLY A 680HIS A 816ASP A 836 | 748 A1001 (-3.7A)748 A1001 (-3.3A)748 A1001 (-3.4A)748 A1001 (-3.2A)748 A1001 ( 4.0A)748 A1001 (-3.8A)748 A1001 (-4.8A) | 0.61A | 3cs9B-5grnA:27.5 | 3cs9B-5grnA:36.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 43GLU A 61MET A 65GLY A 96ALA A 153 | 6G2 A 901 (-3.2A)NoneNone6G2 A 901 (-3.6A)6G2 A 901 ( 4.2A) | 0.67A | 3cs9B-5j5tA:22.0 | 3cs9B-5j5tA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 43MET A 65GLY A 96HIS A 134ALA A 153 | 6G2 A 901 (-3.2A)None6G2 A 901 (-3.6A)None6G2 A 901 ( 4.2A) | 0.60A | 3cs9B-5j5tA:22.0 | 3cs9B-5j5tA:24.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j9z | EPIDERMAL GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 743GLU A 762VAL A 765MET A 766HIS A 835 | 6HJ A1101 (-3.1A)6HJ A1101 ( 4.2A)None6HJ A1101 ( 4.1A)None | 0.67A | 3cs9B-5j9zA:31.0 | 3cs9B-5j9zA:37.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 297GLU A 315VAL A 318MET A 319GLY A 350 | IPW A 601 (-3.5A)IPW A 601 (-3.9A)NoneIPW A 601 (-4.1A)IPW A 601 ( 3.8A) | 0.58A | 3cs9B-5kbrA:22.3 | 3cs9B-5kbrA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 297VAL A 318MET A 319GLY A 350HIS A 387 | IPW A 601 (-3.5A)NoneIPW A 601 (-4.1A)IPW A 601 ( 3.8A)None | 0.84A | 3cs9B-5kbrA:22.3 | 3cs9B-5kbrA:24.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l6o | EPHRIN TYPE-BRECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 663MET A 686THR A 711HIS A 756ASP A 776 | 6P6 A1001 (-3.3A)6P6 A1001 ( 4.2A)6P6 A1001 (-3.5A)DIO A1002 (-4.1A)None | 0.55A | 3cs9B-5l6oA:31.8 | 3cs9B-5l6oA:37.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5td2 | TYROSINE-PROTEINKINASE MER (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 617MET A 641GLY A 677HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)None7AE A1000 ( 3.7A) | 0.60A | 3cs9B-5td2A:30.3 | 3cs9B-5td2A:42.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cnh | SERINE/THREONINE-PROTEIN KINASE PRP4HOMOLOG (Homo sapiens) |
no annotation | 5 | ALA A 715GLU A 732HIS A 813ASP A 834PHE A 835 | 919 A1101 (-3.5A)919 A1101 (-3.7A)919 A1101 (-4.2A)919 A1101 (-4.5A)919 A1101 ( 4.1A) | 0.58A | 3cs9B-6cnhA:21.9 | 3cs9B-6cnhA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cz4 | PROTEIN-TYROSINEKINASE 6 (Homo sapiens) |
no annotation | 5 | ALA A 217THR A 264GLY A 270HIS A 310ASP A 330 | FKY A9001 (-3.3A)FKY A9001 (-3.0A)FKY A9001 (-3.3A)FKY A9001 (-3.9A)None | 0.68A | 3cs9B-6cz4A:22.5 | 3cs9B-6cz4A:18.18 |