SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_A_NILA600_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k2p | TYROSINE-PROTEINKINASE BTK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 428LEU A 457THR A 474GLY A 480PHE A 517HIS A 519LEU A 528 | None | 0.66A | 3cs9A-1k2pA:25.6 | 3cs9A-1k2pA:45.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | ALA A 220GLU A 236MET A 240LEU A 248THR A 266GLY A 272HIS A 312LEU A 321 | None | 0.60A | 3cs9A-1k9aA:31.2 | 3cs9A-1k9aA:31.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | ALA A 220GLU A 236VAL A 239MET A 240THR A 266GLY A 272HIS A 312LEU A 321 | None | 0.62A | 3cs9A-1k9aA:31.2 | 3cs9A-1k9aA:31.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1luf | MUSCLE-SPECIFICTYROSINE KINASERECEPTOR MUSK (Rattusnorvegicus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 606GLY A 660PHE A 720HIS A 722LEU A 731ALA A 741 | None | 0.60A | 3cs9A-1lufA:35.4 | 3cs9A-1lufA:37.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 10 | ALA A 288GLU A 305VAL A 308MET A 309LEU A 317THR A 334GLY A 340HIS A 380LEU A 389ALA A 399 | P16 A 2 (-3.4A)P16 A 2 (-4.2A)NoneP16 A 2 (-3.3A)NoneP16 A 2 (-3.7A)P16 A 2 (-3.4A)NoneP16 A 2 (-4.4A)P16 A 2 (-3.5A) | 0.59A | 3cs9A-1opkA:34.8 | 3cs9A-1opkA:57.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 10 | GLU A 305VAL A 308MET A 309ILE A 312LEU A 317THR A 334GLY A 340HIS A 380LEU A 389ALA A 399 | P16 A 2 (-4.2A)NoneP16 A 2 (-3.3A)NoneNoneP16 A 2 (-3.7A)P16 A 2 (-3.4A)NoneP16 A 2 (-4.4A)P16 A 2 (-3.5A) | 0.70A | 3cs9A-1opkA:34.8 | 3cs9A-1opkA:57.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1py5 | TGF-BETA RECEPTORTYPE I (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 5 | ALA A 230GLY A 286HIS A 331LEU A 340ALA A 350 | PY1 A 700 (-3.5A)PY1 A 700 (-3.6A)NonePY1 A 700 (-4.4A)PY1 A 700 ( 4.2A) | 0.39A | 3cs9A-1py5A:26.0 | 3cs9A-1py5A:27.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1snx | TYROSINE-PROTEINKINASE ITK/TSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 389LEU A 418GLY A 441HIS A 480LEU A 489 | None | 0.41A | 3cs9A-1snxA:22.5 | 3cs9A-1snxA:41.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 621GLU A 640VAL A 643THR A 670GLY A 676HIS A 790LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-4.4A) | 0.50A | 3cs9A-1t46A:34.7 | 3cs9A-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 367GLU A 386MET A 390GLY A 420HIS A 459LEU A 468 | STU A 100 (-3.2A)NoneNoneSTU A 100 (-3.5A)NoneSTU A 100 (-4.5A) | 0.64A | 3cs9A-1u59A:30.7 | 3cs9A-1u59A:38.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buj | SERINE/THREONINE-PROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 47GLU A 65GLY A 104HIS A 146LEU A 155 | STU A1301 (-3.6A)NoneSTU A1301 ( 4.0A)NoneSTU A1301 ( 4.8A) | 0.43A | 3cs9A-2bujA:23.0 | 3cs9A-2bujA:23.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA X 37GLU X 54MET X 58LEU X 66THR X 82GLY X 88LEU X 137ALA X 147 | STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneNoneSTU X 902 (-4.1A)STU X 902 (-3.5A)STU X 902 (-4.4A)STU X 902 ( 4.1A) | 0.71A | 3cs9A-2dq7X:32.3 | 3cs9A-2dq7X:45.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA X 37MET X 58LEU X 66THR X 82GLY X 88HIS X 128LEU X 137ALA X 147 | STU X 902 (-3.1A)NoneNoneSTU X 902 (-4.1A)STU X 902 (-3.5A)NoneSTU X 902 (-4.4A)STU X 902 ( 4.1A) | 0.59A | 3cs9A-2dq7X:32.3 | 3cs9A-2dq7X:45.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eu9 | DUAL SPECIFICITYPROTEIN KINASE CLK3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 184GLU A 201VAL A 204GLY A 240LEU A 290ALA A 319 | None | 1.17A | 3cs9A-2eu9A:21.4 | 3cs9A-2eu9A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eu9 | DUAL SPECIFICITYPROTEIN KINASE CLK3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 184GLU A 201VAL A 204ILE A 208LEU A 290ALA A 319 | None | 0.91A | 3cs9A-2eu9A:21.4 | 3cs9A-2eu9A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | ALA A 293LEU A 322THR A 338GLY A 344HIS A 384LEU A 393ALA A 403 | H8H A 534 (-3.2A)NoneH8H A 534 (-3.1A)H8H A 534 (-3.3A)NoneH8H A 534 (-4.5A)H8H A 534 ( 4.0A) | 0.59A | 3cs9A-2h8hA:30.7 | 3cs9A-2h8hA:27.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322GLY A 344HIS A 384LEU A 393ALA A 403 | QUE A 1 (-3.5A)NoneQUE A 1 (-3.0A)NoneQUE A 1 (-4.4A)QUE A 1 ( 4.5A) | 0.45A | 3cs9A-2hckA:30.2 | 3cs9A-2hckA:30.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322THR A 338GLY A 344LEU A 393ALA A 403 | QUE A 1 (-3.5A)NoneQUE A 1 (-3.3A)QUE A 1 (-3.0A)QUE A 1 (-4.4A)QUE A 1 ( 4.5A) | 0.58A | 3cs9A-2hckA:30.2 | 3cs9A-2hckA:30.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 271GLU A 288VAL A 291MET A 292LEU A 300THR A 316 | 1BM A 499 (-3.6A)1BM A 499 (-3.2A)None1BM A 499 ( 3.8A)None1BM A 499 (-3.2A) | 0.57A | 3cs9A-2hk5A:27.5 | 3cs9A-2hk5A:48.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | ALA A 271VAL A 291MET A 292LEU A 300THR A 316GLY A 322HIS A 362LEU A 371ALA A 381 | 1BM A 499 (-3.6A)None1BM A 499 ( 3.8A)None1BM A 499 (-3.2A)1BM A 499 (-3.5A)None1BM A 499 (-4.4A)1BM A 499 ( 3.7A) | 0.64A | 3cs9A-2hk5A:27.5 | 3cs9A-2hk5A:48.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ALA A 269GLU A 286VAL A 289MET A 290ILE A 293LEU A 298THR A 315GLY A 321LEU A 370ALA A 380 | GIN A 600 (-3.1A)GIN A 600 (-3.6A)NoneGIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-3.4A)NoneGIN A 600 (-4.7A)GIN A 600 (-3.1A) | 0.57A | 3cs9A-2hz0A:35.0 | 3cs9A-2hz0A:98.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | VAL A 289MET A 290ILE A 293LEU A 298THR A 315GLY A 321HIS A 361LEU A 370ALA A 380 | NoneGIN A 600 (-3.2A)GIN A 600 (-4.5A)GIN A 600 (-4.2A)GIN A 600 (-3.4A)NoneGIN A 600 (-4.3A)GIN A 600 (-4.7A)GIN A 600 (-3.1A) | 0.72A | 3cs9A-2hz0A:35.0 | 3cs9A-2hz0A:98.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 7 | ALA A 452GLU A 471MET A 475GLY A 505PHE A 542HIS A 544LEU A 553 | 4ST A1687 (-3.3A)4ST A1687 ( 4.6A)None4ST A1687 (-3.2A)NoneNone4ST A1687 (-4.4A) | 0.69A | 3cs9A-2j0jA:32.7 | 3cs9A-2j0jA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2jkm | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 452MET A 475GLY A 505PHE A 542HIS A 544LEU A 553 | BII A1687 (-3.5A)NoneBII A1687 (-3.6A)NoneNoneBII A1687 (-4.2A) | 0.66A | 3cs9A-2jkmA:32.5 | 3cs9A-2jkmA:40.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | ALA A 271GLU A 288MET A 292LEU A 300THR A 316GLY A 322HIS A 362LEU A 371ALA A 381 | 1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.9A)1N8 A 501 ( 3.3A)1N8 A 501 ( 3.5A)None1N8 A 501 ( 4.3A)1N8 A 501 ( 3.3A) | 0.46A | 3cs9A-2og8A:32.4 | 3cs9A-2og8A:47.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 614GLU A 633MET A 637THR A 663GLY A 669HIS A 776LEU A 785 | None | 0.72A | 3cs9A-2ogvA:32.7 | 3cs9A-2ogvA:38.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p4i | ANGIOPOIETIN-1RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 853VAL A 875GLY A 908HIS A 962LEU A 971ALA A 981 | MR9 A 301 (-3.5A)MR9 A 301 ( 4.8A)MR9 A 301 ( 3.8A)MR9 A 301 (-4.5A)MR9 A 301 (-4.5A)MR9 A 301 (-3.2A) | 0.40A | 3cs9A-2p4iA:23.9 | 3cs9A-2p4iA:37.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 515GLU A 534MET A 538ILE A 541GLY A 570LEU A 633ALA A 643 | None | 0.71A | 3cs9A-2psqA:32.5 | 3cs9A-2psqA:35.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 515MET A 538ILE A 541GLY A 570HIS A 624LEU A 633ALA A 643 | None | 0.58A | 3cs9A-2psqA:32.5 | 3cs9A-2psqA:35.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 215ILE A 233THR A 265HIS A 319LEU A 328ALA A 338 | ADE A 488 (-3.2A)NoneADE A 488 (-4.3A)NoneADE A 488 (-4.4A)None | 1.08A | 3cs9A-2qluA:24.7 | 3cs9A-2qluA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 7 | ALA A 215LEU A 244THR A 265GLY A 271HIS A 319LEU A 328ALA A 338 | ADE A 488 (-3.2A)NoneADE A 488 (-4.3A)ADE A 488 ( 4.1A)NoneADE A 488 (-4.4A)None | 0.56A | 3cs9A-2qluA:24.7 | 3cs9A-2qluA:24.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 749LEU A 780THR A 796GLY A 802HIS A 841LEU A 850 | GW7 A 1 (-3.3A)NoneGW7 A 1 (-4.0A)GW7 A 1 (-3.6A)NoneGW7 A 1 (-4.2A) | 0.75A | 3cs9A-2r4bA:29.6 | 3cs9A-2r4bA:36.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 47GLU A 66VAL A 69GLY A 101LEU A 147ALA A 157 | J60 A1294 (-3.3A)NoneNoneJ60 A1294 ( 3.8A)J60 A1294 (-4.8A)J60 A1294 ( 4.2A) | 0.79A | 3cs9A-2xikA:18.8 | 3cs9A-2xikA:27.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | ALA A 651MET A 674THR A 699GLY A 705HIS A 744 | Q9G A1898 (-3.2A)Q9G A1898 (-3.9A)Q9G A1898 (-3.5A)Q9G A1898 ( 3.8A)None | 0.45A | 3cs9A-2xyuA:27.5 | 3cs9A-2xyuA:38.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 7 | ALA A 273LEU A 302THR A 319GLY A 325HIS A 365LEU A 374ALA A 384 | None | 0.60A | 3cs9A-2zv7A:25.9 | 3cs9A-2zv7A:47.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 273MET A 294LEU A 302THR A 319HIS A 365ALA A 384 | None | 0.78A | 3cs9A-2zv7A:25.9 | 3cs9A-2zv7A:47.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 515MET A 538ILE A 541GLY A 570HIS A 624LEU A 633ALA A 643 | M33 A1996 (-3.3A)NoneNoneM33 A1996 ( 4.8A)NoneM33 A1996 (-4.5A)None | 0.56A | 3cs9A-3b2tA:25.7 | 3cs9A-3b2tA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531GLY A 567HIS A 621LEU A 630ALA A 640 | C4F A 1 (-3.3A)NoneNoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.61A | 3cs9A-3c4fA:31.8 | 3cs9A-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531ILE A 538HIS A 621LEU A 630ALA A 640 | C4F A 1 (-3.3A)NoneNoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.79A | 3cs9A-3c4fA:31.8 | 3cs9A-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512MET A 535GLY A 567HIS A 621LEU A 630ALA A 640 | C4F A 1 (-3.3A)C4F A 1 ( 3.7A)NoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.63A | 3cs9A-3c4fA:31.8 | 3cs9A-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512MET A 535ILE A 538HIS A 621LEU A 630ALA A 640 | C4F A 1 (-3.3A)C4F A 1 ( 3.7A)NoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.82A | 3cs9A-3c4fA:31.8 | 3cs9A-3c4fA:40.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 220GLU A 236MET A 240LEU A 248THR A 266GLY A 272HIS A 312LEU A 321 | None | 0.60A | 3cs9A-3d7uA:27.0 | 3cs9A-3d7uA:44.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 220GLU A 236VAL A 239MET A 240THR A 266GLY A 272HIS A 312LEU A 321 | None | 0.62A | 3cs9A-3d7uA:27.0 | 3cs9A-3d7uA:44.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 6 | ALA A 80MET A 104GLY A 135HIS A 173LEU A 182ALA A 192 | None | 0.75A | 3cs9A-3iecA:22.4 | 3cs9A-3iecA:25.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | ALA A 665GLU A 684MET A 688THR A 713GLY A 719HIS A 758LEU A 767 | NoneNoneNoneNoneGOL A 403 (-3.4A)NoneNone | 0.60A | 3cs9A-3kulA:32.1 | 3cs9A-3kulA:35.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 6 | ALA A 229THR A 279GLY A 285HIS A 330LEU A 339ALA A 349 | LDN A 1 (-3.6A)LDN A 1 (-3.8A)LDN A 1 (-3.3A)NoneLDN A 1 (-4.5A)LDN A 1 ( 3.8A) | 0.46A | 3cs9A-3mdyA:25.2 | 3cs9A-3mdyA:28.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 227THR A 277GLY A 283HIS A 328LEU A 337ALA A 347 | LDN A 600 (-3.2A)LDN A 600 (-4.0A)LDN A 600 (-3.3A)NoneLDN A 600 (-4.6A)LDN A 600 ( 3.8A) | 0.40A | 3cs9A-3my0A:25.0 | 3cs9A-3my0A:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 109GLU A 130MET A 134GLY A 165HIS A 203LEU A 212 | JOZ A 361 (-3.4A)SO4 A 5 (-3.1A)NoneNoneNoneNone | 0.62A | 3cs9A-3nuuA:22.7 | 3cs9A-3nuuA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 109GLU A 130VAL A 133MET A 134GLY A 165LEU A 212 | JOZ A 361 (-3.4A)SO4 A 5 (-3.1A)NoneNoneNoneNone | 0.77A | 3cs9A-3nuuA:22.7 | 3cs9A-3nuuA:25.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pp0 | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 751VAL A 773THR A 798GLY A 804HIS A 843LEU A 852 | 03Q A 1 (-3.1A)None03Q A 1 (-4.1A)03Q A 1 ( 3.9A)None03Q A 1 (-4.4A) | 1.25A | 3cs9A-3pp0A:29.7 | 3cs9A-3pp0A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 6 | ALA A 576MET A 600THR A 625GLY A 631HIS A 674LEU A 683 | STU A 1 (-3.3A)NoneSTU A 1 (-4.1A)STU A 1 (-3.2A)NoneSTU A 1 (-4.3A) | 0.41A | 3cs9A-3ppzA:28.7 | 3cs9A-3ppzA:35.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 6 | GLU A 596MET A 600THR A 625GLY A 631HIS A 674LEU A 683 | NoneNoneSTU A 1 (-4.1A)STU A 1 (-3.2A)NoneSTU A 1 (-4.3A) | 0.52A | 3cs9A-3ppzA:28.7 | 3cs9A-3ppzA:35.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 217THR A 267GLY A 273HIS A 320LEU A 329ALA A 339 | TAK A 2 (-3.5A)TAK A 2 (-3.5A)TAK A 2 (-3.6A)NoneTAK A 2 (-4.6A)TAK A 2 ( 4.2A) | 0.44A | 3cs9A-3q4tA:24.1 | 3cs9A-3q4tA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 217VAL A 235THR A 267GLY A 273LEU A 329ALA A 339 | TAK A 2 (-3.5A)EDO A 489 ( 4.8A)TAK A 2 (-3.5A)TAK A 2 (-3.6A)TAK A 2 (-4.6A)TAK A 2 ( 4.2A) | 0.62A | 3cs9A-3q4tA:24.1 | 3cs9A-3q4tA:25.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 443MET A 464LEU A 472THR A 489GLY A 495HIS A 534LEU A 543 | PP2 A 1 (-3.2A)PP2 A 1 ( 4.3A)NonePP2 A 1 (-3.3A)PP2 A 1 ( 4.2A)NonePP2 A 1 (-4.6A) | 0.44A | 3cs9A-3sxsA:25.9 | 3cs9A-3sxsA:41.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 512GLU A 531MET A 535GLY A 567HIS A 621LEU A 630ALA A 640 | 07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)07J A 1 (-3.7A)None07J A 1 ( 4.4A)07J A 1 (-3.2A) | 0.66A | 3cs9A-3tt0A:30.9 | 3cs9A-3tt0A:35.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 512GLU A 531MET A 535ILE A 538HIS A 621LEU A 630 | 07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)NoneNone07J A 1 ( 4.4A) | 0.80A | 3cs9A-3tt0A:30.9 | 3cs9A-3tt0A:35.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 866GLU A 885ILE A 892GLY A 922HIS A1026LEU A1035 | 4TT A2001 (-3.5A)NoneNone4TT A2001 (-3.7A)None4TT A2001 (-4.8A) | 0.77A | 3cs9A-3vidA:30.8 | 3cs9A-3vidA:34.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 866GLU A 885ILE A 892GLY A 922HIS A1026LEU A1035 | LEV A1201 (-3.5A)LEV A1201 (-3.7A)NoneLEV A1201 (-3.6A)NoneLEV A1201 (-4.8A) | 0.70A | 3cs9A-3wzdA:25.8 | 3cs9A-3wzdA:38.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 649THR A 697GLY A 703HIS A 742LEU A 751 | None | 0.44A | 3cs9A-3zfxA:32.1 | 3cs9A-3zfxA:41.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 866GLU A 885ILE A 892GLY A 922HIS A1026LEU A1035 | B49 A2000 (-3.5A)NoneNoneB49 A2000 ( 3.7A)NoneB49 A2000 (-4.5A) | 0.75A | 3cs9A-4agdA:33.2 | 3cs9A-4agdA:35.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 586GLY A 639PHE A 688HIS A 690LEU A 699 | LTI A1839 (-3.3A)LTI A1839 (-3.4A)NoneNoneLTI A1839 (-4.2A) | 0.37A | 3cs9A-4at3A:34.2 | 3cs9A-4at3A:37.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 6 | ALA A 233THR A 283GLY A 289HIS A 334LEU A 343ALA A 353 | TAK A1507 (-3.3A)TAK A1507 (-3.6A)TAK A1507 (-3.5A)NoneTAK A1507 (-4.7A)TAK A1507 ( 4.2A) | 0.32A | 3cs9A-4c02A:25.0 | 3cs9A-4c02A:28.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 653GLU A 672MET A 676THR A 701GLY A 707HIS A 764LEU A 773ALA A 783 | DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-3.6A)NoneDI1 A1000 (-3.8A)DI1 A1000 (-4.5A)DI1 A1000 (-3.7A) | 0.72A | 3cs9A-4ckrA:32.8 | 3cs9A-4ckrA:37.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | ALA A 684GLU A 705LEU A 720GLY A 743LEU A 789ALA A 799 | AGS A1985 (-3.5A)NoneNoneNoneAGS A1985 (-4.8A)AGS A1985 ( 4.5A) | 0.76A | 3cs9A-4crsA:16.3 | 3cs9A-4crsA:26.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A1148GLU A1167GLY A1202PHE A1245HIS A1247LEU A1256 | 0UV A1501 (-3.4A)None0UV A1501 (-3.6A)NoneNone0UV A1501 (-4.6A) | 0.70A | 3cs9A-4fodA:30.3 | 3cs9A-4fodA:36.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 853GLU A 871GLY A 908HIS A 947LEU A 956ALA A 966 | 19S A1201 (-3.3A)None19S A1201 ( 3.8A)None19S A1201 (-4.5A)19S A1201 ( 4.1A) | 0.54A | 3cs9A-4hviA:30.4 | 3cs9A-4hviA:35.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hzs | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14604(SH3_9) | 6 | ALA A 156LEU A 189GLY A 211PHE A 248HIS A 250LEU A 259 | None | 0.61A | 3cs9A-4hzsA:27.5 | 3cs9A-4hzsA:35.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 156LEU A 189THR A 205GLY A 211HIS A 250LEU A 259 | 1G0 A 401 (-3.6A)None1G0 A 401 (-3.2A)1G0 A 401 ( 4.5A)None1G0 A 401 (-4.6A) | 0.74A | 3cs9A-4id7A:24.5 | 3cs9A-4id7A:39.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | GLU A 177LEU A 189THR A 205GLY A 211HIS A 250LEU A 259 | 1G0 A 401 ( 4.5A)None1G0 A 401 (-3.2A)1G0 A 401 ( 4.5A)None1G0 A 401 (-4.6A) | 0.73A | 3cs9A-4id7A:24.5 | 3cs9A-4id7A:39.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322GLY A 344HIS A 384LEU A 393ALA A 403 | 0J9 A 601 (-3.3A)None0J9 A 601 ( 4.1A)None0J9 A 601 (-4.5A)0J9 A 601 (-3.5A) | 0.37A | 3cs9A-4k11A:30.5 | 3cs9A-4k11A:33.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 506GLU A 525MET A 529ILE A 532GLY A 561LEU A 624ALA A 634 | ACP A 801 (-3.3A)ACP A 801 ( 4.8A)NoneNoneACP A 801 ( 4.6A)ACP A 801 (-4.4A)None | 0.78A | 3cs9A-4k33A:26.4 | 3cs9A-4k33A:38.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 506MET A 529ILE A 532GLY A 561HIS A 615LEU A 624ALA A 634 | ACP A 801 (-3.3A)NoneNoneACP A 801 ( 4.6A)NoneACP A 801 (-4.4A)None | 0.58A | 3cs9A-4k33A:26.4 | 3cs9A-4k33A:38.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 6 | ALA A 293LEU A 322GLY A 344HIS A 384LEU A 393ALA A 403 | VGG A 601 (-3.5A)NoneVGG A 601 ( 3.2A)NoneVGG A 601 (-4.5A)VGG A 601 ( 4.2A) | 0.49A | 3cs9A-4lggA:30.0 | 3cs9A-4lggA:46.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA B 51GLU B 70GLY B 105HIS B 142LEU B 151ALA B 161 | ADP B 500 (-3.3A)NoneNoneNoneADP B 500 (-4.7A)None | 0.85A | 3cs9A-4o27B:18.1 | 3cs9A-4o27B:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA B 51GLU B 70VAL B 73GLY B 105LEU B 151ALA B 161 | ADP B 500 (-3.3A)NoneNoneNoneADP B 500 (-4.7A)None | 0.84A | 3cs9A-4o27B:18.1 | 3cs9A-4o27B:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | ALA A 67GLU A 85MET A 89THR A 123GLY A 128HIS A 171LEU A 180 | SIN A 401 ( 3.7A)NoneNoneNoneSIN A 401 (-3.5A)NoneSIN A 401 ( 4.5A) | 0.83A | 3cs9A-4o38A:19.5 | 3cs9A-4o38A:25.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 642GLU A 661GLY A 697HIS A 809LEU A 818 | P30 A1001 (-3.4A)P30 A1001 (-3.6A)P30 A1001 (-3.4A)P30 A1001 ( 4.3A)P30 A1001 (-4.6A) | 0.34A | 3cs9A-4rt7A:29.4 | 3cs9A-4rt7A:32.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 7 | ALA A 35ILE A 55THR A 81GLY A 87HIS A 127LEU A 136ALA A 146 | ACP A1264 (-2.9A)NoneACP A1264 (-4.5A)ACP A1264 (-3.5A)NoneACP A1264 ( 4.8A)None | 1.45A | 3cs9A-4ueuA:32.8 | 3cs9A-4ueuA:65.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 7 | ALA A 35LEU A 64THR A 81GLY A 87HIS A 127LEU A 136ALA A 146 | ACP A1264 (-2.9A)NoneACP A1264 (-4.5A)ACP A1264 (-3.5A)NoneACP A1264 ( 4.8A)None | 0.45A | 3cs9A-4ueuA:32.8 | 3cs9A-4ueuA:65.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | ALA A 35MET A 56LEU A 64THR A 81HIS A 127LEU A 136 | ACP A1264 (-2.9A)NoneNoneACP A1264 (-4.5A)NoneACP A1264 ( 4.8A) | 0.81A | 3cs9A-4ueuA:32.8 | 3cs9A-4ueuA:65.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 501GLU A 520VAL A 523MET A 524GLY A 556HIS A 610LEU A 619ALA A 629 | 40M A1002 ( 4.1A)40M A1002 (-3.7A)None40M A1002 (-3.8A)40M A1002 ( 3.7A)None40M A1002 (-4.5A)40M A1002 (-3.0A) | 0.62A | 3cs9A-4xcuA:31.6 | 3cs9A-4xcuA:39.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 501GLU A 520VAL A 523MET A 524ILE A 527HIS A 610 | 40M A1002 ( 4.1A)40M A1002 (-3.7A)None40M A1002 (-3.8A)NoneNone | 0.57A | 3cs9A-4xcuA:31.6 | 3cs9A-4xcuA:39.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 9 | ALA B 288VAL B 308MET B 309LEU B 317THR B 334GLY B 340HIS B 380LEU B 389ALA B 399 | 1N1 B 601 (-3.5A)None1N1 B 601 (-3.7A)None1N1 B 601 (-3.3A)1N1 B 601 (-3.5A)None1N1 B 601 (-4.3A)1N1 B 601 (-3.5A) | 0.52A | 3cs9A-4xeyB:35.8 | 3cs9A-4xeyB:74.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 8 | VAL B 308MET B 309ILE B 312LEU B 317GLY B 340HIS B 380LEU B 389ALA B 399 | None1N1 B 601 (-3.7A)NoneNone1N1 B 601 (-3.5A)None1N1 B 601 (-4.3A)1N1 B 601 (-3.5A) | 0.66A | 3cs9A-4xeyB:35.8 | 3cs9A-4xeyB:74.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 428LEU A 457THR A 474GLY A 480HIS A 519LEU A 528 | None | 0.89A | 3cs9A-4xi2A:25.1 | 3cs9A-4xi2A:31.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 428LEU A 457THR A 474GLY A 480PHE A 517LEU A 528 | None | 0.91A | 3cs9A-4xi2A:25.1 | 3cs9A-4xi2A:31.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 6 | ALA A 428LEU A 457THR A 474GLY A 480HIS A 519LEU A 528 | 746 A 702 (-2.4A)None746 A 702 (-3.7A)746 A 702 (-3.6A)None746 A 702 (-4.4A) | 0.59A | 3cs9A-4y93A:31.5 | 3cs9A-4y93A:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 6 | ALA A 428LEU A 457THR A 474GLY A 480PHE A 517LEU A 528 | 746 A 702 (-2.4A)None746 A 702 (-3.7A)746 A 702 (-3.6A)None746 A 702 (-4.4A) | 0.61A | 3cs9A-4y93A:31.5 | 3cs9A-4y93A:28.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 512GLU A 531MET A 535GLY A 567HIS A 621LEU A 630ALA A 640 | 38O A1769 (-3.6A)EDO A1766 (-4.1A)EDO A1766 (-3.5A)38O A1769 (-3.4A)None38O A1769 (-4.6A)EDO A1766 ( 4.4A) | 0.62A | 3cs9A-5a46A:30.9 | 3cs9A-5a46A:38.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8y | TGF-BETA RECEPTORTYPE-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 275ILE A 293THR A 325GLY A 331HIS A 377LEU A 386 | STU A 601 (-3.1A)NoneSTU A 601 ( 3.7A)STU A 601 (-3.5A)NoneSTU A 601 (-3.9A) | 1.19A | 3cs9A-5e8yA:18.6 | 3cs9A-5e8yA:27.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ALA A 625GLU A 644MET A 648THR A 674GLY A 680HIS A 816LEU A 825 | 748 A1001 (-3.7A)748 A1001 (-3.3A)748 A1001 (-3.4A)748 A1001 (-3.2A)748 A1001 ( 4.0A)748 A1001 (-3.8A)748 A1001 (-4.3A) | 0.51A | 3cs9A-5grnA:29.6 | 3cs9A-5grnA:36.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A1108GLY A1163PHE A1200HIS A1202ALA A1221 | 63K A1401 (-3.5A)63K A1401 (-3.6A)NoneNone63K A1401 (-3.3A) | 0.44A | 3cs9A-5horA:26.7 | 3cs9A-5horA:38.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 43GLU A 61MET A 65GLY A 96HIS A 134ALA A 153 | 6G2 A 901 (-3.2A)NoneNone6G2 A 901 (-3.6A)None6G2 A 901 ( 4.2A) | 0.73A | 3cs9A-5j5tA:21.3 | 3cs9A-5j5tA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 43GLU A 61MET A 65GLY A 96LEU A 143ALA A 153 | 6G2 A 901 (-3.2A)NoneNone6G2 A 901 (-3.6A)6G2 A 901 (-4.7A)6G2 A 901 ( 4.2A) | 0.69A | 3cs9A-5j5tA:21.3 | 3cs9A-5j5tA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | ALA A 297GLU A 315VAL A 318MET A 319GLY A 350HIS A 387LEU A 396 | IPW A 601 (-3.5A)IPW A 601 (-3.9A)NoneIPW A 601 (-4.1A)IPW A 601 ( 3.8A)NoneIPW A 601 (-4.5A) | 0.83A | 3cs9A-5kbrA:21.8 | 3cs9A-5kbrA:24.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5td2 | TYROSINE-PROTEINKINASE MER (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 617MET A 641GLY A 677PHE A 719HIS A 721ALA A 740 | 7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)NoneNone7AE A1000 ( 3.7A) | 0.75A | 3cs9A-5td2A:29.5 | 3cs9A-5td2A:42.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6b | TYROSINE-PROTEINKINASE RECEPTOR UFO (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 565GLY A 626PHE A 668HIS A 670ALA A 689 | 7YS A9001 (-3.3A)7YS A9001 (-3.4A)NoneNone7YS A9001 (-3.4A) | 0.32A | 3cs9A-5u6bA:30.4 | 3cs9A-5u6bA:43.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 6 | ALA A 917LEU A 946THR A 963GLY A 969HIS A1008LEU A1017 | ANP A1201 (-3.3A)NoneANP A1201 (-3.9A)ANP A1201 ( 4.6A)NoneANP A1201 (-4.7A) | 0.53A | 3cs9A-5wnoA:28.1 | 3cs9A-5wnoA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccf | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 1 (Homo sapiens) |
no annotation | 5 | ALA A 155GLY A 236HIS A 273LEU A 282ALA A 292 | H1N A 501 (-3.4A)H1N A 501 (-3.6A)NoneH1N A 501 (-4.8A)H1N A 501 ( 3.9A) | 0.37A | 3cs9A-6ccfA:22.2 | 3cs9A-6ccfA:14.13 |