SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_A_NILA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
VAL A 537
 None
 0.91A 3cs9A-1k2pA:
25.6		 3cs9A-1k2pA:
45.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  70
VAL A  78
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
None
 0.52A 3cs9A-1nxkA:
19.3		 3cs9A-1nxkA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
LYS A 290
LYS A 304
ILE A 332
PHE A 336
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
 0.98A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
LYS A 290
VAL A 318
ILE A 332
PHE A 336
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
 0.82A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
PHE A 336
VAL A 398
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
None
 0.64A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.76A 3cs9A-1zy4A:
19.8		 3cs9A-1zy4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B 281
LYS B 296
VAL B 321
ILE B 364
PHE B 368
 None
 0.58A 3cs9A-2a1aB:
21.4		 3cs9A-2a1aB:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
VAL A  73
ASP A 156
 None
 0.92A 3cs9A-2bdwA:
21.5		 3cs9A-2bdwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  26
VAL A  34
LYS A  49
PHE A 100
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
None
 0.74A 3cs9A-2bujA:
23.0		 3cs9A-2bujA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
 0.56A 3cs9A-2dq7X:
32.3		 3cs9A-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
LYS A 186
ILE A 234
VAL A 318
 None
 0.68A 3cs9A-2eu9A:
21.4		 3cs9A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
VAL A 220
ILE A 234
VAL A 318
 None
 0.36A 3cs9A-2eu9A:
21.4		 3cs9A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.70A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
None
 0.85A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
QUE  A   1 (-4.2A)
 0.71A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 643
ILE A 705
PHE A 709
VAL A 770
ASP A 772
 ADP  A 400 ( 4.4A)
None
None
None
ADP  A 400 ( 4.8A)
 0.52A 3cs9A-2henA:
26.3		 3cs9A-2henA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
 0.64A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
VAL A 301
ILE A 314
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.76A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 256
LYS A 271
ILE A 313
PHE A 317
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
 0.56A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
VAL A 299
ILE A 313
PHE A 317
VAL A 379
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.5A)
 0.69A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 299
ILE A 313
PHE A 317
VAL A 379
ASP A 381
 GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.9A)
 0.67A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
LYS A 454
VAL A 484
ILE A 497
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-2.9A)
None
None
None
 0.97A 3cs9A-2jkmA:
32.5		 3cs9A-2jkmA:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
ILE A 314
ASP A 382
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.91A 3cs9A-2og8A:
32.4		 3cs9A-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
VAL A 301
ILE A 314
ASP A 382
 None
None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.57A 3cs9A-2og8A:
32.4		 3cs9A-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.74A 3cs9A-2p3gX:
17.7		 3cs9A-2p3gX:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
LYS A 653
ILE A 697
VAL A 762
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
None
 0.75A 3cs9A-2xyuA:
27.5		 3cs9A-2xyuA:
38.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
PHE A 143
VAL A 124
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
None
 0.83A 3cs9A-2z7rA:
21.8		 3cs9A-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
VAL A 125
PHE A 143
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
 0.48A 3cs9A-2z7rA:
21.8		 3cs9A-2z7rA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
VAL A 303
ILE A 317
 None
 0.80A 3cs9A-2zv7A:
25.9		 3cs9A-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
VAL A 303
ILE A 317
PHE A 321
ASP A 385
 None
 0.79A 3cs9A-2zv7A:
25.9		 3cs9A-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
VAL A 695
ILE A 709
PHE A 713
VAL A 774
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 4.7A)
IHZ  A1001 (-4.8A)
 0.55A 3cs9A-3dkoA:
31.4		 3cs9A-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
None
None
 0.54A 3cs9A-3fmeA:
17.5		 3cs9A-3fmeA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
VAL A 892
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
None
 0.95A 3cs9A-3hngA:
33.1		 3cs9A-3hngA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 565
LYS A 578
VAL A 609
ILE A 623
VAL A 692
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
None
 0.83A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 VAL A  69
LYS A  84
VAL A 115
VAL A 197
ASP A 199
 None
 0.80A 3cs9A-3rp9A:
15.7		 3cs9A-3rp9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  50
VAL A  58
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
 0.66A 3cs9A-3sheA:
18.4		 3cs9A-3sheA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
LYS A 445
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.90A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
VAL A 431
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.46A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		5 LEU A 162
VAL A 170
LYS A 185
VAL A 214
PHE A 232
 None
 0.96A 3cs9A-3utoA:
20.8		 3cs9A-3utoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		5 LEU A 162
VAL A 170
VAL A 214
PHE A 232
ASP A 297
 None
 0.85A 3cs9A-3utoA:
20.8		 3cs9A-3utoA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
PHE A 918
VAL A 898
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.5A)
None
 0.87A 3cs9A-3vidA:
30.7		 3cs9A-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
VAL A 899
PHE A 918
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.5A)
None
 0.68A 3cs9A-3vidA:
30.7		 3cs9A-3vidA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
 None
ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
None
None
 0.68A 3cs9A-3vn9A:
21.9		 3cs9A-3vn9A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.54A 3cs9A-3wigA:
22.4		 3cs9A-3wigA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
PHE A 918
VAL A 898
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-4.7A)
None
 0.83A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
VAL A 899
PHE A 918
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.7A)
 0.48A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
VAL A 899
PHE A 918
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
None
 0.83A 3cs9A-4agdA:
33.3		 3cs9A-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
LYS A 588
VAL A 617
ASP A 710
 LTI  A1839 ( 4.2A)
None
None
None
None
 0.79A 3cs9A-4at3A:
34.2		 3cs9A-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 105
LYS A 123
ILE A 167
PHE A 171
VAL A 232
 30K  A1365 ( 4.6A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.4A)
None
 0.63A 3cs9A-4aw5A:
27.1		 3cs9A-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
LYS A  65
VAL A  94
ILE A 108
PHE A 112
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
 0.69A 3cs9A-4bc6A:
21.6		 3cs9A-4bc6A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A  25
LYS A  40
VAL A  72
ILE A  86
PHE A  90
VAL A 150
 None
 0.78A 3cs9A-4d28A:
20.7		 3cs9A-4d28A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
 0.64A 3cs9A-4eutA:
11.0		 3cs9A-4eutA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
 0.64A 3cs9A-4euuA:
21.4		 3cs9A-4euuA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
 924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
 0.76A 3cs9A-4g34A:
21.0		 3cs9A-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.79A 3cs9A-4idtA:
21.7		 3cs9A-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 SU6  A 701 (-3.6A)
None
None
None
SU6  A 701 (-4.0A)
 0.60A 3cs9A-4jlcA:
18.4		 3cs9A-4jlcA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.56A 3cs9A-4k11A:
30.5		 3cs9A-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
None
0J9  A 601 (-4.4A)
None
 0.74A 3cs9A-4k11A:
30.5		 3cs9A-4k11A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
VAL A  41
LYS A  56
ILE A  97
VAL A  82
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
None
None
 0.92A 3cs9A-4lg4A:
17.5		 3cs9A-4lg4A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
LYS A  56
LYS A  69
VAL A  83
ILE A  97
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
 1.16A 3cs9A-4lg4A:
17.5		 3cs9A-4lg4A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.75A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.50A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
None
 0.99A 3cs9A-4rt7A:
29.4		 3cs9A-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.70A 3cs9A-4ueuA:
32.6		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
VAL A  65
ILE A  79
VAL A 145
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.67A 3cs9A-4ueuA:
32.6		 3cs9A-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  40
VAL A  48
VAL A  92
ILE A 106
PHE A 110
 6UI  A 700 ( 4.9A)
None
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
 0.75A 3cs9A-4usfA:
18.5		 3cs9A-4usfA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
PHE A 128
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.8A)
 0.70A 3cs9A-4wsqA:
22.6		 3cs9A-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 290
LYS B 304
ILE B 332
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-4.1A)
None
 1.16A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 290
VAL B 318
ILE B 332
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
 0.83A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 304
ILE B 332
PHE B 336
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
None
1N1  B 601 (-4.1A)
1N1  B 601 ( 4.2A)
None
 0.98A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
VAL B 318
ILE B 332
PHE B 336
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 ( 4.2A)
None
 0.68A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 None
 0.87A 3cs9A-4xi2A:
25.1		 3cs9A-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
None
 0.71A 3cs9A-4xufA:
34.0		 3cs9A-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
None
None
 0.91A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.50A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 LEU A  99
VAL A 107
LYS A 122
PHE A 172
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
None
 0.63A 3cs9A-5eykA:
17.3		 3cs9A-5eykA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
LYS A 627
ILE A 672
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-4.8A)
 0.89A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
VAL A 658
ILE A 672
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.8A)
 0.74A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.50A 3cs9A-5i3oA:
22.4		 3cs9A-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
LYS A  45
VAL A  74
ILE A  88
PHE A  92
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
 0.55A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
LYS A 665
ILE A 709
PHE A 713
VAL A 774
ASP A 776
 None
None
6P6  A1001 ( 4.5A)
6P6  A1001 ( 4.5A)
DIO  A1002 (-4.9A)
None
 0.57A 3cs9A-5l6oA:
33.5		 3cs9A-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 5 LEU A 468
VAL A 476
LYS A 491
VAL A 527
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.66A 3cs9A-5o0yA:
20.9		 3cs9A-5o0yA:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 542
VAL A 550
LYS A 567
PHE A 622
VAL A 688
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
None
7YS  A9001 (-4.3A)
None
 0.89A 3cs9A-5u6bA:
30.4		 3cs9A-5u6bA:
43.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.66A 3cs9A-5u94A:
15.0		 3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.73A 3cs9A-5u94A:
15.0		 3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 686
VAL A 694
LYS A 709
VAL A 738
ILE A 752
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
None
 0.77A 3cs9A-5vilA:
19.0		 3cs9A-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
VAL A  41
LYS A  56
VAL A  83
ILE A  97
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 (-2.4A)
None
None
 0.81A 3cs9A-6ao5A:
22.2		 3cs9A-6ao5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
VAL A 889
LYS A 908
VAL A 938
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
None
 0.50A 3cs9A-6c7yA:
20.7		 3cs9A-6c7yA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 283
LYS A 298
VAL A 327
PHE A 345
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.6A)
None
FE7  A 601 (-4.5A)
 0.69A 3cs9A-6cthA:
22.0		 3cs9A-6cthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 283
VAL A 327
PHE A 345
ASP A 411
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
None
FE7  A 601 (-4.5A)
MG  A 602 ( 2.6A)
 0.84A 3cs9A-6cthA:
22.0		 3cs9A-6cthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 LEU A 197
VAL A 205
ILE A 262
VAL A 328
ASP A 330
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
FKY  A9001 (-4.7A)
None
 0.64A 3cs9A-6cz4A:
21.8		 3cs9A-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 LEU A 197
VAL A 205
LYS A 219
ILE A 262
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.7A)
 0.86A 3cs9A-6cz4A:
21.8		 3cs9A-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 LEU U  20
VAL U  28
LYS U  44
VAL U  75
PHE U  93
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
 0.69A 3cs9A-6fdyU:
21.8		 3cs9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 LEU U  20
VAL U  28
VAL U  75
PHE U  93
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-3.6A)
 0.92A 3cs9A-6fdyU:
21.8		 3cs9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
VAL A 177
VAL A 227
ILE A 241
VAL A 325
ASP A 327
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
None
None
None
3NG  A 501 (-4.5A)
 0.80A 3cs9A-6fylA:
21.7		 3cs9A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.65A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.61A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.6A)
 0.96A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
 0.61A 3cs9A-6fyvA:
21.6		 3cs9A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 3NG  A 501 (-3.9A)
None
None
None
3NG  A 501 (-4.3A)
 0.90A 3cs9A-6fyvA:
21.6		 3cs9A-6fyvA:
undetectable