SIMILAR PATTERNS OF AMINO ACIDS FOR 3CS9_A_NILA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
VAL A 537
 None
 0.91A 3cs9A-1k2pA:
25.6		 3cs9A-1k2pA:
45.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  70
VAL A  78
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
None
 0.52A 3cs9A-1nxkA:
19.3		 3cs9A-1nxkA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
LYS A 290
LYS A 304
ILE A 332
PHE A 336
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
 0.98A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
LYS A 290
VAL A 318
ILE A 332
PHE A 336
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
 0.82A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
PHE A 336
VAL A 398
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
None
 0.64A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.76A 3cs9A-1zy4A:
19.8		 3cs9A-1zy4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B 281
LYS B 296
VAL B 321
ILE B 364
PHE B 368
 None
 0.58A 3cs9A-2a1aB:
21.4		 3cs9A-2a1aB:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
VAL A  73
ASP A 156
 None
 0.92A 3cs9A-2bdwA:
21.5		 3cs9A-2bdwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  26
VAL A  34
LYS A  49
PHE A 100
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
None
 0.74A 3cs9A-2bujA:
23.0		 3cs9A-2bujA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
 0.56A 3cs9A-2dq7X:
32.3		 3cs9A-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
LYS A 186
ILE A 234
VAL A 318
 None
 0.68A 3cs9A-2eu9A:
21.4		 3cs9A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
VAL A 220
ILE A 234
VAL A 318
 None
 0.36A 3cs9A-2eu9A:
21.4		 3cs9A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.70A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
None
 0.85A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
QUE  A   1 (-4.2A)
 0.71A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 643
ILE A 705
PHE A 709
VAL A 770
ASP A 772
 ADP  A 400 ( 4.4A)
None
None
None
ADP  A 400 ( 4.8A)
 0.52A 3cs9A-2henA:
26.3		 3cs9A-2henA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
 0.64A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
VAL A 301
ILE A 314
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.76A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 256
LYS A 271
ILE A 313
PHE A 317
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
 0.56A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
VAL A 299
ILE A 313
PHE A 317
VAL A 379
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.5A)
 0.69A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 299
ILE A 313
PHE A 317
VAL A 379
ASP A 381
 GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.9A)
 0.67A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
LYS A 454
VAL A 484
ILE A 497
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-2.9A)
None
None
None
 0.97A 3cs9A-2jkmA:
32.5		 3cs9A-2jkmA:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
LYS A 273
ILE A 314
ASP A 382
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.91A 3cs9A-2og8A:
32.4		 3cs9A-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
VAL A 301
ILE A 314
ASP A 382
 None
None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.57A 3cs9A-2og8A:
32.4		 3cs9A-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.74A 3cs9A-2p3gX:
17.7		 3cs9A-2p3gX:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
LYS A 653
ILE A 697
VAL A 762
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
None
 0.75A 3cs9A-2xyuA:
27.5		 3cs9A-2xyuA:
38.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
PHE A 143
VAL A 124
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
None
 0.83A 3cs9A-2z7rA:
21.8		 3cs9A-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
VAL A 125
PHE A 143
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
 0.48A 3cs9A-2z7rA:
21.8		 3cs9A-2z7rA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
VAL A 303
ILE A 317
 None
 0.80A 3cs9A-2zv7A:
25.9		 3cs9A-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
VAL A 303
ILE A 317
PHE A 321
ASP A 385
 None
 0.79A 3cs9A-2zv7A:
25.9		 3cs9A-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
VAL A 695
ILE A 709
PHE A 713
VAL A 774
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 4.7A)
IHZ  A1001 (-4.8A)
 0.55A 3cs9A-3dkoA:
31.4		 3cs9A-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
None
None
 0.54A 3cs9A-3fmeA:
17.5		 3cs9A-3fmeA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
VAL A 892
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
None
 0.95A 3cs9A-3hngA:
33.1		 3cs9A-3hngA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 565
LYS A 578
VAL A 609
ILE A 623
VAL A 692
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
None
 0.83A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 VAL A  69
LYS A  84
VAL A 115
VAL A 197
ASP A 199
 None
 0.80A 3cs9A-3rp9A:
15.7		 3cs9A-3rp9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  50
VAL A  58
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
 0.66A 3cs9A-3sheA:
18.4		 3cs9A-3sheA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
LYS A 445
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.90A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
VAL A 431
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.46A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		5 LEU A 162
VAL A 170
LYS A 185
VAL A 214
PHE A 232
 None
 0.96A 3cs9A-3utoA:
20.8		 3cs9A-3utoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		5 LEU A 162
VAL A 170
VAL A 214
PHE A 232
ASP A 297
 None
 0.85A 3cs9A-3utoA:
20.8		 3cs9A-3utoA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
PHE A 918
VAL A 898
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.5A)
None
 0.87A 3cs9A-3vidA:
30.7		 3cs9A-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
VAL A 899
PHE A 918
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.5A)
None
 0.68A 3cs9A-3vidA:
30.7		 3cs9A-3vidA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
VAL A 113
ILE A 127
 None
ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
None
None
 0.68A 3cs9A-3vn9A:
21.9		 3cs9A-3vn9A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.54A 3cs9A-3wigA:
22.4		 3cs9A-3wigA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
PHE A 918
VAL A 898
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-4.7A)
None
 0.83A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
VAL A 899
PHE A 918
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.7A)
 0.48A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
VAL A 899
PHE A 918
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
None
 0.83A 3cs9A-4agdA:
33.3		 3cs9A-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
LYS A 588
VAL A 617
ASP A 710
 LTI  A1839 ( 4.2A)
None
None
None
None
 0.79A 3cs9A-4at3A:
34.2		 3cs9A-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 105
LYS A 123
ILE A 167
PHE A 171
VAL A 232
 30K  A1365 ( 4.6A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.4A)
None
 0.63A 3cs9A-4aw5A:
27.1		 3cs9A-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
LYS A  65
VAL A  94
ILE A 108
PHE A 112
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
 0.69A 3cs9A-4bc6A:
21.6		 3cs9A-4bc6A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A  25
LYS A  40
VAL A  72
ILE A  86
PHE A  90
VAL A 150
 None
 0.78A 3cs9A-4d28A:
20.7		 3cs9A-4d28A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
 0.64A 3cs9A-4eutA:
11.0		 3cs9A-4eutA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
 0.64A 3cs9A-4euuA:
21.4		 3cs9A-4euuA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
 924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
 0.76A 3cs9A-4g34A:
21.0		 3cs9A-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.79A 3cs9A-4idtA:
21.7		 3cs9A-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 SU6  A 701 (-3.6A)
None
None
None
SU6  A 701 (-4.0A)
 0.60A 3cs9A-4jlcA:
18.4		 3cs9A-4jlcA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.56A 3cs9A-4k11A:
30.5		 3cs9A-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
None
0J9  A 601 (-4.4A)
None
 0.74A 3cs9A-4k11A:
30.5		 3cs9A-4k11A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
VAL A  41
LYS A  56
ILE A  97
VAL A  82
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
None
None
 0.92A 3cs9A-4lg4A:
17.5		 3cs9A-4lg4A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
LYS A  56
LYS A  69
VAL A  83
ILE A  97
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
 1.16A 3cs9A-4lg4A:
17.5		 3cs9A-4lg4A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.75A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.50A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
None
 0.99A 3cs9A-4rt7A:
29.4		 3cs9A-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
VAL A  65
ILE A  79
VAL A 145
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.70A 3cs9A-4ueuA:
32.6		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
VAL A  65
ILE A  79
VAL A 145
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
None
 0.67A 3cs9A-4ueuA:
32.6		 3cs9A-4ueuA:
65.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  40
VAL A  48
VAL A  92
ILE A 106
PHE A 110
 6UI  A 700 ( 4.9A)
None
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
 0.75A 3cs9A-4usfA:
18.5		 3cs9A-4usfA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
PHE A 128
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.8A)
 0.70A 3cs9A-4wsqA:
22.6		 3cs9A-4wsqA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 290
LYS B 304
ILE B 332
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-4.1A)
None
 1.16A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 290
VAL B 318
ILE B 332
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
 0.83A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
LYS B 304
ILE B 332
PHE B 336
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
None
1N1  B 601 (-4.1A)
1N1  B 601 ( 4.2A)
None
 0.98A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
VAL B 318
ILE B 332
PHE B 336
VAL B 398
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 ( 4.2A)
None
 0.68A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 None
 0.87A 3cs9A-4xi2A:
25.1		 3cs9A-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
VAL A 675
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
None
 0.71A 3cs9A-4xufA:
34.0		 3cs9A-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
LYS A 430
VAL A 458
ILE A 472
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-3.7A)
None
None
 0.91A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
None
 0.50A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 LEU A  99
VAL A 107
LYS A 122
PHE A 172
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
None
 0.63A 3cs9A-5eykA:
17.3		 3cs9A-5eykA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
LYS A 627
ILE A 672
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-4.8A)
 0.89A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
VAL A 658
ILE A 672
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.8A)
 0.74A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.50A 3cs9A-5i3oA:
22.4		 3cs9A-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
LYS A  45
VAL A  74
ILE A  88
PHE A  92
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
 0.55A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
LYS A 665
ILE A 709
PHE A 713
VAL A 774
ASP A 776
 None
None
6P6  A1001 ( 4.5A)
6P6  A1001 ( 4.5A)
DIO  A1002 (-4.9A)
None
 0.57A 3cs9A-5l6oA:
33.5		 3cs9A-5l6oA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 5 LEU A 468
VAL A 476
LYS A 491
VAL A 527
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.66A 3cs9A-5o0yA:
20.9		 3cs9A-5o0yA:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 542
VAL A 550
LYS A 567
PHE A 622
VAL A 688
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
None
7YS  A9001 (-4.3A)
None
 0.89A 3cs9A-5u6bA:
30.4		 3cs9A-5u6bA:
43.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.66A 3cs9A-5u94A:
15.0		 3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.73A 3cs9A-5u94A:
15.0		 3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 686
VAL A 694
LYS A 709
VAL A 738
ILE A 752
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
None
 0.77A 3cs9A-5vilA:
19.0		 3cs9A-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
VAL A  41
LYS A  56
VAL A  83
ILE A  97
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 (-2.4A)
None
None
 0.81A 3cs9A-6ao5A:
22.2		 3cs9A-6ao5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
VAL A 889
LYS A 908
VAL A 938
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
None
 0.50A 3cs9A-6c7yA:
20.7		 3cs9A-6c7yA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 283
LYS A 298
VAL A 327
PHE A 345
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.6A)
None
FE7  A 601 (-4.5A)
 0.69A 3cs9A-6cthA:
22.0		 3cs9A-6cthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 283
VAL A 327
PHE A 345
ASP A 411
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
None
FE7  A 601 (-4.5A)
MG  A 602 ( 2.6A)
 0.84A 3cs9A-6cthA:
22.0		 3cs9A-6cthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 LEU A 197
VAL A 205
ILE A 262
VAL A 328
ASP A 330
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
FKY  A9001 (-4.7A)
None
 0.64A 3cs9A-6cz4A:
21.8		 3cs9A-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 LEU A 197
VAL A 205
LYS A 219
ILE A 262
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.7A)
 0.86A 3cs9A-6cz4A:
21.8		 3cs9A-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 LEU U  20
VAL U  28
LYS U  44
VAL U  75
PHE U  93
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
 0.69A 3cs9A-6fdyU:
21.8		 3cs9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 LEU U  20
VAL U  28
VAL U  75
PHE U  93
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-3.6A)
 0.92A 3cs9A-6fdyU:
21.8		 3cs9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
VAL A 177
VAL A 227
ILE A 241
VAL A 325
ASP A 327
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
None
None
None
3NG  A 501 (-4.5A)
 0.80A 3cs9A-6fylA:
21.7		 3cs9A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.65A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.61A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.6A)
 0.96A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
 0.61A 3cs9A-6fyvA:
21.6		 3cs9A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 3NG  A 501 (-3.9A)
None
None
None
3NG  A 501 (-4.3A)
 0.90A 3cs9A-6fyvA:
21.6		 3cs9A-6fyvA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
HIS A 519
LEU A 528
 None
 0.66A 3cs9A-1k2pA:
25.6		 3cs9A-1k2pA:
45.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 220
GLU A 236
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.60A 3cs9A-1k9aA:
31.2		 3cs9A-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 220
GLU A 236
VAL A 239
MET A 240
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.62A 3cs9A-1k9aA:
31.2		 3cs9A-1k9aA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 606
GLY A 660
PHE A 720
HIS A 722
LEU A 731
ALA A 741
 None
 0.60A 3cs9A-1lufA:
35.4		 3cs9A-1lufA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ALA A 288
GLU A 305
VAL A 308
MET A 309
LEU A 317
THR A 334
GLY A 340
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.59A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.70A 3cs9A-1opkA:
34.8		 3cs9A-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
GLY A 286
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.39A 3cs9A-1py5A:
26.0		 3cs9A-1py5A:
27.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 389
LEU A 418
GLY A 441
HIS A 480
LEU A 489
 None
 0.41A 3cs9A-1snxA:
22.5		 3cs9A-1snxA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
GLU A 640
VAL A 643
THR A 670
GLY A 676
HIS A 790
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
 0.50A 3cs9A-1t46A:
34.7		 3cs9A-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
GLU A 386
MET A 390
GLY A 420
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
None
STU  A 100 (-4.5A)
 0.64A 3cs9A-1u59A:
30.7		 3cs9A-1u59A:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
GLU A  65
GLY A 104
HIS A 146
LEU A 155
 STU  A1301 (-3.6A)
None
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
 0.43A 3cs9A-2bujA:
23.0		 3cs9A-2bujA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA X  37
GLU X  54
MET X  58
LEU X  66
THR X  82
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.71A 3cs9A-2dq7X:
32.3		 3cs9A-2dq7X:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA X  37
MET X  58
LEU X  66
THR X  82
GLY X  88
HIS X 128
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.59A 3cs9A-2dq7X:
32.3		 3cs9A-2dq7X:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
GLU A 201
VAL A 204
GLY A 240
LEU A 290
ALA A 319
 None
 1.17A 3cs9A-2eu9A:
21.4		 3cs9A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
GLU A 201
VAL A 204
ILE A 208
LEU A 290
ALA A 319
 None
 0.91A 3cs9A-2eu9A:
21.4		 3cs9A-2eu9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
LEU A 322
THR A 338
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.59A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.45A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.58A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
 0.57A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.64A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
VAL A 289
MET A 290
ILE A 293
LEU A 298
THR A 315
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.57A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 289
MET A 290
ILE A 293
LEU A 298
THR A 315
GLY A 321
HIS A 361
LEU A 370
ALA A 380
 None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.72A 3cs9A-2hz0A:
35.0		 3cs9A-2hz0A:
98.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
GLU A 471
MET A 475
GLY A 505
PHE A 542
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
None
4ST  A1687 (-4.4A)
 0.69A 3cs9A-2j0jA:
32.7		 3cs9A-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 452
MET A 475
GLY A 505
PHE A 542
HIS A 544
LEU A 553
 BII  A1687 (-3.5A)
None
BII  A1687 (-3.6A)
None
None
BII  A1687 (-4.2A)
 0.66A 3cs9A-2jkmA:
32.5		 3cs9A-2jkmA:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 271
GLU A 288
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
LEU A 371
ALA A 381
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.46A 3cs9A-2og8A:
32.4		 3cs9A-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
MET A 637
THR A 663
GLY A 669
HIS A 776
LEU A 785
 None
 0.72A 3cs9A-2ogvA:
32.7		 3cs9A-2ogvA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
VAL A 875
GLY A 908
HIS A 962
LEU A 971
ALA A 981
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.8A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
 0.40A 3cs9A-2p4iA:
23.9		 3cs9A-2p4iA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.71A 3cs9A-2psqA:
32.5		 3cs9A-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
LEU A 633
ALA A 643
 None
 0.58A 3cs9A-2psqA:
32.5		 3cs9A-2psqA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
ILE A 233
THR A 265
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
ADE  A 488 (-4.4A)
None
 1.08A 3cs9A-2qluA:
24.7		 3cs9A-2qluA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LEU A 244
THR A 265
GLY A 271
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.56A 3cs9A-2qluA:
24.7		 3cs9A-2qluA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 749
LEU A 780
THR A 796
GLY A 802
HIS A 841
LEU A 850
 GW7  A   1 (-3.3A)
None
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.75A 3cs9A-2r4bA:
29.6		 3cs9A-2r4bA:
36.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  47
GLU A  66
VAL A  69
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.79A 3cs9A-2xikA:
18.8		 3cs9A-2xikA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
MET A 674
THR A 699
GLY A 705
HIS A 744
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
None
 0.45A 3cs9A-2xyuA:
27.5		 3cs9A-2xyuA:
38.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 273
LEU A 302
THR A 319
GLY A 325
HIS A 365
LEU A 374
ALA A 384
 None
 0.60A 3cs9A-2zv7A:
25.9		 3cs9A-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
MET A 294
LEU A 302
THR A 319
HIS A 365
ALA A 384
 None
 0.78A 3cs9A-2zv7A:
25.9		 3cs9A-2zv7A:
47.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.56A 3cs9A-3b2tA:
25.7		 3cs9A-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.61A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
ILE A 538
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.79A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
MET A 535
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
MET A 535
ILE A 538
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.82A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 220
GLU A 236
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.60A 3cs9A-3d7uA:
27.0		 3cs9A-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 220
GLU A 236
VAL A 239
MET A 240
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.62A 3cs9A-3d7uA:
27.0		 3cs9A-3d7uA:
44.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
MET A 104
GLY A 135
HIS A 173
LEU A 182
ALA A 192
 None
 0.75A 3cs9A-3iecA:
22.4		 3cs9A-3iecA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
HIS A 758
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.60A 3cs9A-3kulA:
32.1		 3cs9A-3kulA:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
THR A 279
GLY A 285
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.46A 3cs9A-3mdyA:
25.2		 3cs9A-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
THR A 277
GLY A 283
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.40A 3cs9A-3my0A:
25.0		 3cs9A-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
MET A 134
GLY A 165
HIS A 203
LEU A 212
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
None
 0.62A 3cs9A-3nuuA:
22.7		 3cs9A-3nuuA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
VAL A 133
MET A 134
GLY A 165
LEU A 212
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
None
 0.77A 3cs9A-3nuuA:
22.7		 3cs9A-3nuuA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 751
VAL A 773
THR A 798
GLY A 804
HIS A 843
LEU A 852
 03Q  A   1 (-3.1A)
None
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 1.25A 3cs9A-3pp0A:
29.7		 3cs9A-3pp0A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
MET A 600
THR A 625
GLY A 631
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
 0.41A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLU A 596
MET A 600
THR A 625
GLY A 631
HIS A 674
LEU A 683
 None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
 0.52A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
THR A 267
GLY A 273
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.44A 3cs9A-3q4tA:
24.1		 3cs9A-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
VAL A 235
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.62A 3cs9A-3q4tA:
24.1		 3cs9A-3q4tA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
MET A 464
LEU A 472
THR A 489
GLY A 495
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
 0.44A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.66A 3cs9A-3tt0A:
30.9		 3cs9A-3tt0A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
LEU A 630
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
None
07J  A   1 ( 4.4A)
 0.80A 3cs9A-3tt0A:
30.9		 3cs9A-3tt0A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEU A1035
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
 0.77A 3cs9A-3vidA:
30.8		 3cs9A-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEU A1035
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
None
LEV  A1201 (-4.8A)
 0.70A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
THR A 697
GLY A 703
HIS A 742
LEU A 751
 None
 0.44A 3cs9A-3zfxA:
32.1		 3cs9A-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEU A1035
 B49  A2000 (-3.5A)
None
None
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
 0.75A 3cs9A-4agdA:
33.2		 3cs9A-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 586
GLY A 639
PHE A 688
HIS A 690
LEU A 699
 LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
None
LTI  A1839 (-4.2A)
 0.37A 3cs9A-4at3A:
34.2		 3cs9A-4at3A:
37.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
THR A 283
GLY A 289
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.32A 3cs9A-4c02A:
25.0		 3cs9A-4c02A:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 653
GLU A 672
MET A 676
THR A 701
GLY A 707
HIS A 764
LEU A 773
ALA A 783
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
 0.72A 3cs9A-4ckrA:
32.8		 3cs9A-4ckrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 684
GLU A 705
LEU A 720
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3cs9A-4crsA:
16.3		 3cs9A-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1148
GLU A1167
GLY A1202
PHE A1245
HIS A1247
LEU A1256
 0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
None
None
0UV  A1501 (-4.6A)
 0.70A 3cs9A-4fodA:
30.3		 3cs9A-4fodA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLU A 871
GLY A 908
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
None
19S  A1201 ( 3.8A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.54A 3cs9A-4hviA:
30.4		 3cs9A-4hviA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 ALA A 156
LEU A 189
GLY A 211
PHE A 248
HIS A 250
LEU A 259
 None
 0.61A 3cs9A-4hzsA:
27.5		 3cs9A-4hzsA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
LEU A 259
 1G0  A 401 (-3.6A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.74A 3cs9A-4id7A:
24.5		 3cs9A-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 177
LEU A 189
THR A 205
GLY A 211
HIS A 250
LEU A 259
 1G0  A 401 ( 4.5A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.73A 3cs9A-4id7A:
24.5		 3cs9A-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.37A 3cs9A-4k11A:
30.5		 3cs9A-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
GLU A 525
MET A 529
ILE A 532
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.78A 3cs9A-4k33A:
26.4		 3cs9A-4k33A:
38.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
MET A 529
ILE A 532
GLY A 561
HIS A 615
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 ( 4.6A)
None
ACP  A 801 (-4.4A)
None
 0.58A 3cs9A-4k33A:
26.4		 3cs9A-4k33A:
38.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.49A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA B  51
GLU B  70
GLY B 105
HIS B 142
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 (-4.7A)
None
 0.85A 3cs9A-4o27B:
18.1		 3cs9A-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA B  51
GLU B  70
VAL B  73
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 (-4.7A)
None
 0.84A 3cs9A-4o27B:
18.1		 3cs9A-4o27B:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
HIS A 171
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.83A 3cs9A-4o38A:
19.5		 3cs9A-4o38A:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
GLU A 661
GLY A 697
HIS A 809
LEU A 818
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
 0.34A 3cs9A-4rt7A:
29.4		 3cs9A-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
ILE A  55
THR A  81
GLY A  87
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 1.45A 3cs9A-4ueuA:
32.8		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
LEU A  64
THR A  81
GLY A  87
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.45A 3cs9A-4ueuA:
32.8		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
MET A  56
LEU A  64
THR A  81
HIS A 127
LEU A 136
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
 0.81A 3cs9A-4ueuA:
32.8		 3cs9A-4ueuA:
65.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 501
GLU A 520
VAL A 523
MET A 524
GLY A 556
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.62A 3cs9A-4xcuA:
31.6		 3cs9A-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
HIS A 610
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
None
 0.57A 3cs9A-4xcuA:
31.6		 3cs9A-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 ALA B 288
VAL B 308
MET B 309
LEU B 317
THR B 334
GLY B 340
HIS B 380
LEU B 389
ALA B 399
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.52A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 308
MET B 309
ILE B 312
LEU B 317
GLY B 340
HIS B 380
LEU B 389
ALA B 399
 None
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.66A 3cs9A-4xeyB:
35.8		 3cs9A-4xeyB:
74.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
LEU A 528
 None
 0.89A 3cs9A-4xi2A:
25.1		 3cs9A-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
LEU A 528
 None
 0.91A 3cs9A-4xi2A:
25.1		 3cs9A-4xi2A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
LEU A 528
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
 0.59A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
LEU A 528
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
 0.61A 3cs9A-4y93A:
31.5		 3cs9A-4y93A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.62A 3cs9A-5a46A:
30.9		 3cs9A-5a46A:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
ILE A 293
THR A 325
GLY A 331
HIS A 377
LEU A 386
 STU  A 601 (-3.1A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
None
STU  A 601 (-3.9A)
 1.19A 3cs9A-5e8yA:
18.6		 3cs9A-5e8yA:
27.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
HIS A 816
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
 0.51A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
GLY A1163
PHE A1200
HIS A1202
ALA A1221
 63K  A1401 (-3.5A)
63K  A1401 (-3.6A)
None
None
63K  A1401 (-3.3A)
 0.44A 3cs9A-5horA:
26.7		 3cs9A-5horA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
GLY A  96
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
None
6G2  A 901 ( 4.2A)
 0.73A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 3cs9A-5j5tA:
21.3		 3cs9A-5j5tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 297
GLU A 315
VAL A 318
MET A 319
GLY A 350
HIS A 387
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.83A 3cs9A-5kbrA:
21.8		 3cs9A-5kbrA:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 617
MET A 641
GLY A 677
PHE A 719
HIS A 721
ALA A 740
 7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
None
None
7AE  A1000 ( 3.7A)
 0.75A 3cs9A-5td2A:
29.5		 3cs9A-5td2A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 565
GLY A 626
PHE A 668
HIS A 670
ALA A 689
 7YS  A9001 (-3.3A)
7YS  A9001 (-3.4A)
None
None
7YS  A9001 (-3.4A)
 0.32A 3cs9A-5u6bA:
30.4		 3cs9A-5u6bA:
43.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 ALA A 917
LEU A 946
THR A 963
GLY A 969
HIS A1008
LEU A1017
 ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
ANP  A1201 (-4.7A)
 0.53A 3cs9A-5wnoA:
28.1		 3cs9A-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 155
GLY A 236
HIS A 273
LEU A 282
ALA A 292
 H1N  A 501 (-3.4A)
H1N  A 501 (-3.6A)
None
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.37A 3cs9A-6ccfA:
22.2		 3cs9A-6ccfA:
14.13