SIMILAR PATTERNS OF AMINO ACIDS FOR 3CR4_X_PNTX101_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cw0 | PROTEIN (DNAMISMATCHENDONUCLEASE) (Escherichiacoli) |
PF03852(Vsr) | 3 | CYH A 73HIS A 72PHE A 76 | ZN A 201 (-2.3A)NoneNone | 0.89A | 3cr4X-1cw0A:undetectable | 3cr4X-1cw0A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5m | BETA KETOACYL ACYLCARRIER PROTEINSYNTHASE II (Synechocystissp. PCC 6803) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | CYH A 83HIS A 79PHE A 80 | None | 1.18A | 3cr4X-1e5mA:0.0 | 3cr4X-1e5mA:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eyw | PHOSPHOTRIESTERASE (Brevundimonasdiminuta) |
PF02126(PTE) | 3 | CYH A 59HIS A 57PHE A 306 | None ZN A 401 (-3.3A)TEN A 403 (-4.4A) | 0.92A | 3cr4X-1eywA:undetectable | 3cr4X-1eywA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foe | T-LYMPHOMA INVASIONAND METASTASISINDUCING PROTEIN 1 (Mus musculus) |
PF00169(PH)PF00621(RhoGEF) | 3 | CYH A1146HIS A1149PHE A1145 | None | 1.07A | 3cr4X-1foeA:1.0 | 3cr4X-1foeA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 3 | CYH A 202HIS A 4PHE A 204 | None | 1.13A | 3cr4X-1j6oA:undetectable | 3cr4X-1j6oA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lwd | ISOCITRATEDEHYDROGENASE (Sus scrofa) |
PF00180(Iso_dh) | 3 | CYH A 196HIS A 194PHE A 197 | None | 1.14A | 3cr4X-1lwdA:undetectable | 3cr4X-1lwdA:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5h | FORMIMINOTETRAHYDROFOLATE CYCLODEAMINASE (Thermotogamaritima) |
PF04961(FTCD_C) | 3 | CYH A 145HIS A 146PHE A 149 | None | 0.98A | 3cr4X-1o5hA:undetectable | 3cr4X-1o5hA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odg | DNA MISMATCHENDONUCLEASE (Escherichiacoli) |
PF03852(Vsr) | 3 | CYH A 73HIS A 72PHE A 76 | ZN A 200 (-1.9A)NoneNone | 0.86A | 3cr4X-1odgA:undetectable | 3cr4X-1odgA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qf6 | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF00587(tRNA-synt_2b)PF02824(TGS)PF03129(HGTP_anticodon)PF07973(tRNA_SAD) | 3 | CYH A 193HIS A 194PHE A 196 | None | 1.23A | 3cr4X-1qf6A:0.0 | 3cr4X-1qf6A:9.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qls | S100C PROTEIN (Sus scrofa) |
PF00036(EF-hand_1)PF01023(S_100) | 3 | CYH A 89HIS A 90PHE A 93 | None | 1.00A | 3cr4X-1qlsA:13.6 | 3cr4X-1qlsA:35.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rxt | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE 1 (Homo sapiens) |
PF01233(NMT)PF02799(NMT_C) | 3 | CYH A 135HIS A 134PHE A 148 | None | 1.20A | 3cr4X-1rxtA:undetectable | 3cr4X-1rxtA:9.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tke | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF02824(TGS)PF07973(tRNA_SAD) | 3 | CYH A 193HIS A 194PHE A 196 | None | 1.09A | 3cr4X-1tkeA:undetectable | 3cr4X-1tkeA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjn | ZN-DEPENDENTHYDROLASE OFMETALLO-BETA-LACTAMASE SUPERFAMILYTM0207 (Thermotogamaritima) |
PF13483(Lactamase_B_3) | 3 | CYH A 107HIS A 108PHE A 99 | None | 0.82A | 3cr4X-1vjnA:undetectable | 3cr4X-1vjnA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x4k | SKELETAL MUSCLELIM-PROTEIN 3 (Homo sapiens) |
PF00412(LIM) | 3 | CYH A 36HIS A 37PHE A 34 | ZN A 401 (-2.3A)NoneNone | 1.14A | 3cr4X-1x4kA:undetectable | 3cr4X-1x4kA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y13 | 6-PYRUVOYLTETRAHYDROPTERINSYNTHASE (Plasmodiumfalciparum) |
PF01242(PTPS) | 3 | CYH A 27HIS A 29PHE A 82 | None ZN A 174 ( 3.5A)None | 0.95A | 3cr4X-1y13A:undetectable | 3cr4X-1y13A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygg | PHOSPHOENOLPYRUVATECARBOXYKINASE (Actinobacillussuccinogenes) |
PF01293(PEPCK_ATP) | 3 | CYH A 408HIS A 232PHE A 247 | None | 1.18A | 3cr4X-1yggA:0.0 | 3cr4X-1yggA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykw | RUBISCO-LIKE PROTEIN (Chlorobaculumtepidum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | CYH A 103HIS A 102PHE A 105 | None | 1.12A | 3cr4X-1ykwA:undetectable | 3cr4X-1ykwA:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zb1 | BRO1 PROTEIN (Saccharomycescerevisiae) |
PF03097(BRO1) | 3 | CYH A 245HIS A 248PHE A 288 | None | 1.09A | 3cr4X-1zb1A:0.0 | 3cr4X-1zb1A:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0s | 6-PYRUVOYLTETRAHYDROPTERINSYNTHASE (Plasmodiumvivax) |
PF01242(PTPS) | 3 | CYH A 34HIS A 36PHE A 89 | None ZN A 281 ( 3.5A)None | 0.99A | 3cr4X-2a0sA:undetectable | 3cr4X-2a0sA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2con | NIN ONE BINDINGPROTEIN (Mus musculus) |
PF08772(NOB1_Zn_bind) | 3 | CYH A 21HIS A 19PHE A 22 | ZN A 201 (-2.3A)NoneNone | 0.89A | 3cr4X-2conA:undetectable | 3cr4X-2conA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibu | ACETYL-COAACETYLTRANSFERASE (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | CYH A 196HIS A 192PHE A 356 | NoneCOA A6001 (-4.5A)COA A6001 (-4.5A) | 1.21A | 3cr4X-2ibuA:0.0 | 3cr4X-2ibuA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2idv | EUKARYOTICTRANSLATIONINITIATION FACTOR4E-1 (Triticumaestivum) |
PF01652(IF4E) | 3 | CYH A 99HIS A 98PHE A 100 | None | 1.15A | 3cr4X-2idvA:undetectable | 3cr4X-2idvA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7q | MCMV TEGUMENTPROTEIN M48 ENCODEDUBIQUITIN- SPECIFICPROTEASE, M48USP (Muridbetaherpesvirus1) |
PF04843(Herpes_teg_N) | 3 | CYH A 34HIS A 32PHE A 200 | None | 1.14A | 3cr4X-2j7qA:0.0 | 3cr4X-2j7qA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kkn | UNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF12850(Metallophos_2) | 3 | CYH A 87HIS A 88PHE A 73 | None | 1.20A | 3cr4X-2kknA:undetectable | 3cr4X-2kknA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kv1 | METHIONINE-R-SULFOXIDE REDUCTASE B1 (Mus musculus) |
PF01641(SelR) | 3 | CYH A 95HIS A 80PHE A 97 | None | 0.73A | 3cr4X-2kv1A:undetectable | 3cr4X-2kv1A:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m89 | AHA1 DOMAIN PROTEIN (Colwelliapsychrerythraea) |
PF08327(AHSA1) | 3 | CYH A 114HIS A 113PHE A 110 | None | 1.21A | 3cr4X-2m89A:undetectable | 3cr4X-2m89A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n47 | SLR1183 PROTEIN (Synechocystissp. PCC 6803) |
PF13649(Methyltransf_25) | 3 | CYH A 103HIS A 104PHE A 102 | None | 1.23A | 3cr4X-2n47A:undetectable | 3cr4X-2n47A:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmo | SER/THR PROTEINKINASE (Plasmodiumfalciparum) |
PF00069(Pkinase) | 3 | CYH X 169HIS X 170PHE X 159 | None | 0.65A | 3cr4X-2pmoX:undetectable | 3cr4X-2pmoX:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9i | RHAMNULOSE-1-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF00596(Aldolase_II) | 3 | CYH A 126HIS A 125PHE A 122 | None | 1.20A | 3cr4X-2v9iA:undetectable | 3cr4X-2v9iA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdu | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE-ASSOCIATED WD REPEATPROTEIN TRM82 (Saccharomycescerevisiae) |
no annotation | 3 | CYH B 230HIS B 226PHE B 231 | None | 1.00A | 3cr4X-2vduB:undetectable | 3cr4X-2vduB:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsx | EUKARYOTICINITIATION FACTOR 4FSUBUNIT P150 (Saccharomycescerevisiae) |
PF02854(MIF4G) | 3 | CYH E 703HIS E 704PHE E 707 | None | 1.04A | 3cr4X-2vsxE:undetectable | 3cr4X-2vsxE:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x2i | ALPHA-1,4-GLUCANLYASE ISOZYME 1 (Gracilariopsislemaneiformis) |
PF01055(Glyco_hydro_31) | 3 | CYH A 819HIS A 806PHE A 875 | None | 1.13A | 3cr4X-2x2iA:undetectable | 3cr4X-2x2iA:6.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsj | SULFITE REDUCTASEALPHA SUBUNIT (Desulfomicrobiumnorvegicum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 3 | CYH A 85HIS A 64PHE A 91 | None | 1.13A | 3cr4X-2xsjA:undetectable | 3cr4X-2xsjA:11.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xxz | LYSINE-SPECIFICDEMETHYLASE 6B (Homo sapiens) |
PF02373(JmjC) | 3 | CYH A1422HIS A1425PHE A1421 | None | 0.96A | 3cr4X-2xxzA:undetectable | 3cr4X-2xxzA:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2znm | THIOL:DISULFIDEINTERCHANGE PROTEINDSBA (Neisseriameningitidis) |
PF13462(Thioredoxin_4) | 3 | CYH A 37HIS A 36PHE A 40 | None | 1.14A | 3cr4X-2znmA:undetectable | 3cr4X-2znmA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axx | 458AA LONGHYPOTHETICALENDO-1,4-BETA-GLUCANASE (Pyrococcushorikoshii) |
PF00150(Cellulase) | 3 | CYH A 372HIS A 62PHE A 374 | None | 1.18A | 3cr4X-3axxA:undetectable | 3cr4X-3axxA:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bfo | MUCOSA-ASSOCIATEDLYMPHOID TISSUELYMPHOMATRANSLOCATIONPROTEIN 1 (ISOFORM2) (Homo sapiens) |
PF13895(Ig_2) | 3 | CYH A 290HIS A 291PHE A 261 | None | 0.71A | 3cr4X-3bfoA:undetectable | 3cr4X-3bfoA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cuq | VACUOLARPROTEIN-SORTING-ASSOCIATED PROTEIN 25 (Homo sapiens) |
PF05871(ESCRT-II) | 3 | CYH C 41HIS C 44PHE C 5 | None | 1.14A | 3cr4X-3cuqC:undetectable | 3cr4X-3cuqC:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwl | ACTIN-RELATEDPROTEIN 2/3 COMPLEXSUBUNIT 2 (Schizosaccharomycespombe) |
PF04045(P34-Arc) | 3 | CYH D 258HIS D 249PHE D 250 | None | 1.17A | 3cr4X-3dwlD:0.6 | 3cr4X-3dwlD:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dxq | CHOLINE/ETHANOLAMINEKINASE FAMILYPROTEIN (Mesorhizobiumloti) |
PF01633(Choline_kinase) | 3 | CYH A 175HIS A 176PHE A 113 | None | 0.75A | 3cr4X-3dxqA:undetectable | 3cr4X-3dxqA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs9 | PROTEIN GP18 (Listeriamonocytogenes) |
PF06605(Prophage_tail) | 3 | CYH A 113HIS A 116PHE A 108 | None | 1.11A | 3cr4X-3gs9A:undetectable | 3cr4X-3gs9A:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhj | MUTATOR MUTT PROTEIN (Bartonellahenselae) |
PF14815(NUDIX_4) | 3 | CYH A 114HIS A 116PHE A 93 | None | 0.88A | 3cr4X-3hhjA:undetectable | 3cr4X-3hhjA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hq0 | CATECHOL2,3-DIOXYGENASE (Pseudomonasalkylphenolica) |
PF00903(Glyoxalase) | 3 | CYH A 254HIS A 248PHE A 269 | None | 0.91A | 3cr4X-3hq0A:undetectable | 3cr4X-3hq0A:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibt | 1H-3-HYDROXY-4-OXOQUINOLINE2,4-DIOXYGENASE (Pseudomonasputida) |
PF12697(Abhydrolase_6) | 3 | CYH A 209HIS A 210PHE A 234 | None | 1.13A | 3cr4X-3ibtA:undetectable | 3cr4X-3ibtA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0w | MUCOSA-ASSOCIATEDLYMPHOID TISSUELYMPHOMATRANSLOCATIONPROTEIN 1, ISOFORM 2 (Homo sapiens) |
PF13895(Ig_2)PF13927(Ig_3) | 3 | CYH A 290HIS A 291PHE A 261 | None | 0.85A | 3cr4X-3k0wA:undetectable | 3cr4X-3k0wA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8k | ALPHA-AMYLASE, SUSG (Bacteroidesthetaiotaomicron) |
PF00128(Alpha-amylase) | 3 | CYH A 346HIS A 344PHE A 345 | NoneNoneACT A 961 ( 4.2A) | 1.17A | 3cr4X-3k8kA:undetectable | 3cr4X-3k8kA:8.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3s | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Ruegeriapomeroyi) |
PF00378(ECH_1) | 3 | CYH A 65HIS A 29PHE A 64 | None | 1.21A | 3cr4X-3l3sA:undetectable | 3cr4X-3l3sA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n29 | CARBOXYNORSPERMIDINEDECARBOXYLASE (Campylobacterjejuni) |
PF00278(Orn_DAP_Arg_deC) | 3 | CYH A 124HIS A 164PHE A 165 | NonePLP A1001 ( 4.8A)None | 0.95A | 3cr4X-3n29A:undetectable | 3cr4X-3n29A:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3z | HIGH AFFINITYCGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 9A (Homo sapiens) |
PF00233(PDEase_I) | 3 | CYH A 241HIS A 243PHE A 240 | None | 1.10A | 3cr4X-3n3zA:0.0 | 3cr4X-3n3zA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nic | ECO29KIR (Escherichiacoli) |
PF09517(RE_Eco29kI) | 3 | CYH A 125HIS A 35PHE A 127 | None | 1.03A | 3cr4X-3nicA:undetectable | 3cr4X-3nicA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3or2 | SULFITE REDCUTASESUBUNIT ALPHA (Desulfovibriogigas) |
PF01077(NIR_SIR) | 3 | CYH A 85HIS A 64PHE A 91 | None | 1.06A | 3cr4X-3or2A:undetectable | 3cr4X-3or2A:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qi3 | HIGH AFFINITYCGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 9A (Homo sapiens) |
PF00233(PDEase_I) | 3 | CYH A 241HIS A 243PHE A 240 | None | 1.11A | 3cr4X-3qi3A:undetectable | 3cr4X-3qi3A:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qjg | EPIDERMINBIOSYNTHESIS PROTEINEPID (Staphylococcusaureus) |
PF02441(Flavoprotein) | 3 | CYH A 103HIS A 104PHE A 107 | None | 0.85A | 3cr4X-3qjgA:undetectable | 3cr4X-3qjgA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2j | ALPHA/BETA-HYDROLASE-LIKE PROTEIN (Leishmaniainfantum) |
PF00857(Isochorismatase) | 3 | CYH A 80HIS A 85PHE A 82 | None | 1.14A | 3cr4X-3r2jA:undetectable | 3cr4X-3r2jA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETATYPE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 3 | CYH A 493HIS A 492PHE A 415 | None | 0.67A | 3cr4X-3txoA:1.1 | 3cr4X-3txoA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6m | 458AA LONGHYPOTHETICALENDO-1,4-BETA-GLUCANASE (Pyrococcushorikoshii) |
PF00150(Cellulase) | 3 | CYH A 372HIS A 62PHE A 374 | None | 1.08A | 3cr4X-3w6mA:undetectable | 3cr4X-3w6mA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqh | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Trypanosomabrucei) |
PF01704(UDPGP) | 3 | CYH A 148HIS A 147PHE A 144 | None | 1.07A | 3cr4X-4bqhA:undetectable | 3cr4X-4bqhA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ce4 | MRPL22MRPL39 (Sus scrofa;Sus scrofa) |
PF00237(Ribosomal_L22)no annotation | 3 | CYH c 88HIS c 91PHE W 134 | None | 1.23A | 3cr4X-4ce4c:undetectable | 3cr4X-4ce4c:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d0n | A-KINASE ANCHORPROTEIN 13 (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 3 | CYH B2105HIS B2108PHE B2104 | None | 1.05A | 3cr4X-4d0nB:1.1 | 3cr4X-4d0nB:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d0o | A-KINASE ANCHORPROTEIN 13 (Homo sapiens) |
PF00621(RhoGEF) | 3 | CYH A2105HIS A2108PHE A2104 | None | 1.13A | 3cr4X-4d0oA:1.1 | 3cr4X-4d0oA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyu | LYSINE-SPECIFICDEMETHYLASE 6B (Mus musculus) |
PF02373(JmjC) | 3 | CYH A1425HIS A1428PHE A1424 | None | 1.07A | 3cr4X-4eyuA:undetectable | 3cr4X-4eyuA:10.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f5x | RNA-DIRECTED RNAPOLYMERASE (Rotavirus A) |
PF02123(RdRP_4)PF12289(Rotavirus_VP1) | 3 | CYH W 38HIS W 42PHE W 41 | None | 0.89A | 3cr4X-4f5xW:undetectable | 3cr4X-4f5xW:7.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgm | AMINOPEPTIDASE NFAMILY PROTEIN (Idiomarinaloihiensis) |
PF05299(Peptidase_M61)PF13180(PDZ_2) | 3 | CYH A 272HIS A 273PHE A 276 | None ZN A 602 ( 3.4A)None | 0.93A | 3cr4X-4fgmA:undetectable | 3cr4X-4fgmA:9.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6v | AMIDOHYDROLASE 2 (Planctopiruslimnophila) |
PF02614(UxaC) | 3 | CYH A 264HIS A 267PHE A 263 | None | 1.14A | 3cr4X-4i6vA:undetectable | 3cr4X-4i6vA:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4joi | CST COMPLEX SUBUNITSTN1 (Homo sapiens) |
PF01336(tRNA_anti-codon)PF09170(STN1_2) | 3 | CYH A 88HIS A 148PHE A 72 | None | 0.95A | 3cr4X-4joiA:undetectable | 3cr4X-4joiA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4keq | 4-PYRIDOXOLACTONASE (Mesorhizobiumjaponicum) |
PF00753(Lactamase_B) | 3 | CYH A 102HIS A 101PHE A 99 | None ZN A 301 (-3.2A)5PN A 303 (-4.4A) | 1.10A | 3cr4X-4keqA:undetectable | 3cr4X-4keqA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n4g | ZINC FINGER MYNDDOMAIN-CONTAININGPROTEIN 11 (Mus musculus) |
PF00439(Bromodomain)PF00855(PWWP) | 3 | CYH A 274HIS A 353PHE A 273 | None | 1.20A | 3cr4X-4n4gA:undetectable | 3cr4X-4n4gA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ns5 | ZINC FINGER MYNDDOMAIN-CONTAININGPROTEIN 11 (Homo sapiens) |
PF00439(Bromodomain)PF00855(PWWP) | 3 | CYH A 274HIS A 353PHE A 273 | None | 1.20A | 3cr4X-4ns5A:undetectable | 3cr4X-4ns5A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1j | CARBONIC ANHYDRASE (Sordariamacrospora) |
PF00484(Pro_CA) | 3 | CYH A 99HIS A 101PHE A 184 | None ZN A 301 (-3.4A)None | 1.17A | 3cr4X-4o1jA:undetectable | 3cr4X-4o1jA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ohc | OROTATEPHOSPHORIBOSYLTRANSFERASE (Burkholderiacenocepacia) |
PF00156(Pribosyltran) | 3 | CYH A 156HIS A 180PHE A 157 | None | 1.15A | 3cr4X-4ohcA:undetectable | 3cr4X-4ohcA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pay | SIDC, INTERAPTIN (Legionellapneumophila) |
no annotation | 3 | CYH A 468HIS A 469PHE A 460 | None | 1.07A | 3cr4X-4payA:undetectable | 3cr4X-4payA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2h | PROLINE RACEMASEPROTEIN (Agrobacteriumtumefaciens) |
PF05544(Pro_racemase) | 3 | CYH A 171HIS A 152PHE A 150 | None | 1.13A | 3cr4X-4q2hA:undetectable | 3cr4X-4q2hA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qb5 | GLYOXALASE/BLEOMYCINRESISTANCEPROTEIN/DIOXYGENASE (Rhodoferaxferrireducens) |
PF00903(Glyoxalase) | 3 | CYH A 76HIS A 80PHE A 79 | None | 1.04A | 3cr4X-4qb5A:undetectable | 3cr4X-4qb5A:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlb | PROBABLE GLYCOGEN[STARCH] SYNTHASE (Caenorhabditiselegans) |
PF05693(Glycogen_syn) | 3 | CYH A 289HIS A 286PHE A 287 | None | 1.06A | 3cr4X-4qlbA:0.9 | 3cr4X-4qlbA:8.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r3u | 2-HYDROXYISOBUTYRYL-COA MUTASE LARGESUBUNIT (Aquincolatertiaricarbonis) |
PF01642(MM_CoA_mutase) | 3 | CYH A 331HIS A 366PHE A 288 | None5AD A 803 ( 4.8A)3KK A 802 ( 4.1A) | 1.20A | 3cr4X-4r3uA:undetectable | 3cr4X-4r3uA:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4trg | SIDC (Legionellapneumophila) |
no annotation | 3 | CYH A 468HIS A 469PHE A 460 | None | 1.05A | 3cr4X-4trgA:undetectable | 3cr4X-4trgA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9v | N-ALPHA-ACETYLTRANSFERASE 40 (Homo sapiens) |
PF00583(Acetyltransf_1) | 3 | CYH B 137HIS B 123PHE B 124 | ACO B 301 ( 4.3A)NoneNone | 1.14A | 3cr4X-4u9vB:undetectable | 3cr4X-4u9vB:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wyq | ENDORIBONUCLEASEDICERRISC-LOADING COMPLEXSUBUNIT TARBP2 (Homo sapiens;Homo sapiens) |
no annotationPF16482(Staufen_C) | 3 | CYH B 337HIS B 338PHE A 353 | None | 1.00A | 3cr4X-4wyqB:undetectable | 3cr4X-4wyqB:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xsv | ETHANOLAMINE-PHOSPHATECYTIDYLYLTRANSFERASE (Homo sapiens) |
PF01467(CTP_transf_like) | 3 | CYH A 306HIS A 307PHE A 331 | NoneC5P A 401 (-3.4A)None | 1.18A | 3cr4X-4xsvA:undetectable | 3cr4X-4xsvA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yh8 | SPLICING FACTOR U2AF23 KDA SUBUNIT (Schizosaccharomycespombe) |
PF00076(RRM_1)PF00642(zf-CCCH) | 3 | CYH A 27HIS A 102PHE A 20 | ZN A 301 (-2.4A)NoneNone | 1.14A | 3cr4X-4yh8A:undetectable | 3cr4X-4yh8A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z61 | PHYTOSULFOKINERECEPTOR 1 (Daucus carota) |
PF00560(LRR_1)PF13855(LRR_8) | 3 | CYH A 399HIS A 398PHE A 424 | None | 0.85A | 3cr4X-4z61A:undetectable | 3cr4X-4z61A:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zuz | SIDC (Legionellapneumophila) |
no annotation | 3 | CYH A 469HIS A 470PHE A 461 | None | 1.14A | 3cr4X-4zuzA:undetectable | 3cr4X-4zuzA:7.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a30 | MITOCHONDRIALPROTEIN (Gallus gallus) |
PF03828(PAP_assoc) | 3 | CYH A 413HIS A 406PHE A 415 | None | 0.70A | 3cr4X-5a30A:1.1 | 3cr4X-5a30A:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqd | T-BOX TRANSCRIPTIONFACTOR TBX5 (Homo sapiens) |
PF00907(T-box) | 3 | CYH A 202HIS A 184PHE A 201 | None | 1.14A | 3cr4X-5bqdA:undetectable | 3cr4X-5bqdA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsw | 4-COUMARATE--COALIGASE 2 (Nicotianatabacum) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | CYH A 31HIS A 28PHE A 32 | None | 1.11A | 3cr4X-5bswA:undetectable | 3cr4X-5bswA:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5din | LIGAND OF NUMBPROTEIN X 2 (Homo sapiens) |
PF13923(zf-C3HC4_2) | 3 | CYH A 31HIS A 32PHE A 50 | ZN A 201 (-2.3A)NoneNone | 1.14A | 3cr4X-5dinA:undetectable | 3cr4X-5dinA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ful | PROTEIN ARGININEN-METHYLTRANSFERASE2 (Mus musculus) |
PF05175(MTS) | 3 | CYH A 167HIS A 170PHE A 166 | None | 1.21A | 3cr4X-5fulA:undetectable | 3cr4X-5fulA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7s | E3 UBIQUITIN-PROTEINLIGASE LNX (Homo sapiens) |
no annotation | 3 | CYH D 101HIS D 100PHE D 97 | ZN D 204 (-2.3A)NoneNone | 1.00A | 3cr4X-5h7sD:undetectable | 3cr4X-5h7sD:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxf | 3C PROTEASE (Enterovirus A) |
PF00548(Peptidase_C3) | 3 | CYH A 172HIS A 162PHE A 171 | NoneAG7 A 201 (-4.0A)AG7 A 201 (-4.1A) | 1.14A | 3cr4X-5hxfA:undetectable | 3cr4X-5hxfA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jm7 | AEROBACTIN SYNTHASEIUCA (Klebsiellapneumoniae) |
PF04183(IucA_IucC)PF06276(FhuF) | 3 | CYH A 102HIS A 106PHE A 105 | None | 0.94A | 3cr4X-5jm7A:undetectable | 3cr4X-5jm7A:10.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIII (Homo sapiens) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3) | 3 | CYH A 310HIS A 311PHE A 270 | CU A 808 (-2.2A)NoneNone | 0.93A | 3cr4X-5k8dA:undetectable | 3cr4X-5k8dA:9.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lst | ATP-DEPENDENT DNAHELICASE Q4 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | CYH A 636HIS A 635PHE A 637 | None | 1.15A | 3cr4X-5lstA:undetectable | 3cr4X-5lstA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mgv | PHENYLALANINE--TRNALIGASE,MITOCHONDRIAL (Homo sapiens) |
PF01409(tRNA-synt_2d)PF03147(FDX-ACB) | 3 | CYH A 377HIS A 376PHE A 333 | None | 1.17A | 3cr4X-5mgvA:undetectable | 3cr4X-5mgvA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mv9 | UNCONVENTIONALMYOSIN-VIIA (Homo sapiens) |
PF00373(FERM_M)PF00784(MyTH4) | 3 | CYH A2182HIS A2168PHE A2167 | None | 1.06A | 3cr4X-5mv9A:undetectable | 3cr4X-5mv9A:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tsc | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 3 | CYH A 177HIS A 178PHE A 181 | None | 0.90A | 3cr4X-5tscA:undetectable | 3cr4X-5tscA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 3 | CYH A 25HIS A 28PHE A 24 | None | 1.02A | 3cr4X-5ucyA:undetectable | 3cr4X-5ucyA:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF10588(NADH-G_4Fe-4S_3)PF13459(Fer4_15)PF13510(Fer2_4) | 3 | CYH B 105HIS B 103PHE B 104 | SF4 B 301 (-2.3A)SF4 B 301 (-3.2A)None | 1.23A | 3cr4X-5xfaB:undetectable | 3cr4X-5xfaB:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9d | ACYL-COENZYME AOXIDASE 1 (Yarrowialipolytica) |
no annotation | 3 | CYH A 197HIS A 196PHE A 115 | None | 1.00A | 3cr4X-5y9dA:undetectable | 3cr4X-5y9dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cnh | SERINE/THREONINE-PROTEIN KINASE PRP4HOMOLOG (Homo sapiens) |
no annotation | 3 | CYH A 750HIS A 749PHE A 748 | 919 A1101 ( 4.4A)NoneNone | 1.21A | 3cr4X-6cnhA:undetectable | 3cr4X-6cnhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cp0 | - (-) |
no annotation | 3 | CYH A 464HIS A 465PHE A 456 | None | 1.22A | 3cr4X-6cp0A:1.2 | 3cr4X-6cp0A:undetectable |