SIMILAR PATTERNS OF AMINO ACIDS FOR 3CO4_A_GCSA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcp DCOH

(Rattus
norvegicus) 		PF01329
(Pterin_4a) 		3 GLU A  65
HIS A  63
HIS A  62
 None
HBI  A 105 (-3.6A)
HBI  A 105 (-3.8A)
 0.91A 3co4A-1dcpA:
undetectable		 3co4A-1dcpA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 GLU A 256
HIS A 253
HIS A 115
 None
AMP  A 700 (-4.0A)
None
 0.76A 3co4A-1dgsA:
undetectable		 3co4A-1dgsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 GLU A   1
HIS A 223
HIS A 219
 None
 0.70A 3co4A-1exfA:
undetectable		 3co4A-1exfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 GLU A  78
HIS A 117
HIS A 134
 None
 0.77A 3co4A-1ey2A:
undetectable		 3co4A-1ey2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 GLU A 401
HIS A 365
HIS A 335
 None
None
FE2  A1001 (-3.4A)
 0.79A 3co4A-1ey2A:
undetectable		 3co4A-1ey2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 GLU A  91
HIS A  89
HIS A  72
 None
 0.93A 3co4A-1fc4A:
2.1		 3co4A-1fc4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		3 GLU A  29
HIS A  26
HIS A  56
 None
 0.78A 3co4A-1gvfA:
4.4		 3co4A-1gvfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 GLU A 118
HIS A  42
HIS A  43
 None
None
ZN  A 600 (-3.3A)
 0.91A 3co4A-1hp1A:
2.4		 3co4A-1hp1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzg SUFE PROTEIN

(Escherichia
coli) 		PF02657
(SufE) 		3 GLU A 140
HIS A 145
HIS A 146
 None
 0.91A 3co4A-1mzgA:
undetectable		 3co4A-1mzgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		3 GLU A 182
HIS A 135
HIS A 139
 None
 0.94A 3co4A-1nd4A:
undetectable		 3co4A-1nd4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		3 GLU A 136
HIS A 133
HIS A 132
 None
DHK  A 239 (-4.8A)
None
 0.90A 3co4A-1sfjA:
11.1		 3co4A-1sfjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 GLU A   4
HIS A  64
HIS A  62
 None
 0.92A 3co4A-1u3iA:
undetectable		 3co4A-1u3iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5p SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 GLU A1767
HIS A1769
HIS A1772
 None
 0.87A 3co4A-1u5pA:
undetectable		 3co4A-1u5pA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		3 GLU A 162
HIS A 170
HIS A 120
 None
 0.87A 3co4A-1vl5A:
undetectable		 3co4A-1vl5A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans) 		PF04616
(Glyco_hydro_43) 		3 GLU A 295
HIS A 286
HIS A  41
 None
 0.93A 3co4A-1wl7A:
undetectable		 3co4A-1wl7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 GLU A 290
HIS A 284
HIS A 283
 None
 0.91A 3co4A-1wp9A:
undetectable		 3co4A-1wp9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4v HYPOTHETICAL PROTEIN
LOC130617

(Homo sapiens) 		PF01428
(zf-AN1) 		3 GLU A  16
HIS A  41
HIS A  47
 None
ZN  A 201 (-3.3A)
ZN  A 401 (-3.5A)
 0.82A 3co4A-1x4vA:
undetectable		 3co4A-1x4vA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xox APOPTOSIS INHIBITOR
SURVIVIN

(Homo sapiens) 		PF00653
(BIR) 		3 GLU A  75
HIS A  77
HIS A  80
 None
ZN  A 999 (-2.7A)
None
 0.71A 3co4A-1xoxA:
undetectable		 3co4A-1xoxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xre SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 GLU A  88
HIS A  83
HIS A  80
 None
MN  A 209 (-3.2A)
None
 0.85A 3co4A-1xreA:
undetectable		 3co4A-1xreA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 GLU R  14
HIS R  20
HIS R  19
 None
 0.80A 3co4A-1y6nR:
undetectable		 3co4A-1y6nR:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1

(Enterococcus
faecalis) 		PF04962
(KduI) 		3 GLU A1107
HIS A1132
HIS A1133
 None
 0.87A 3co4A-1ywkA:
undetectable		 3co4A-1ywkA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00782
(DSPc) 		3 GLU A 264
HIS A 193
HIS A 262
 SO4  A 502 ( 3.9A)
None
None
 0.87A 3co4A-2g6zA:
undetectable		 3co4A-2g6zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		3 GLU A 111
HIS A 190
HIS A 234
 None
 0.81A 3co4A-2h2wA:
undetectable		 3co4A-2h2wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		3 GLU A 756
HIS A 689
HIS A 614
 None
 0.93A 3co4A-2hwkA:
undetectable		 3co4A-2hwkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		3 GLU B 174
HIS B 218
HIS B 217
 None
 0.65A 3co4A-2iaeB:
undetectable		 3co4A-2iaeB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 GLU A 354
HIS A 329
HIS A 332
 None
 0.81A 3co4A-2incA:
undetectable		 3co4A-2incA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr5 UPF0350 PROTEIN
VC_2471

(Vibrio cholerae) 		PF03937
(Sdh5) 		3 GLU A  88
HIS A  90
HIS A  91
 None
 0.93A 3co4A-2jr5A:
undetectable		 3co4A-2jr5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2js5 UNCHARACTERIZED
PROTEIN

(Methylococcus
capsulatus) 		PF05082
(Rop-like) 		3 GLU A  65
HIS A  68
HIS A  69
 None
 0.75A 3co4A-2js5A:
undetectable		 3co4A-2js5A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiw INT PROTEIN

(Staphylococcus
haemolyticus) 		PF14659
(Phage_int_SAM_3) 		3 GLU A 166
HIS A 172
HIS A 173
 None
 0.86A 3co4A-2kiwA:
undetectable		 3co4A-2kiwA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiw INT PROTEIN

(Staphylococcus
haemolyticus) 		PF14659
(Phage_int_SAM_3) 		3 GLU A 168
HIS A 172
HIS A 173
 None
 0.88A 3co4A-2kiwA:
undetectable		 3co4A-2kiwA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krt CONSERVED
HYPOTHETICAL
MEMBRANE LIPOPROTEIN

(Ureaplasma
parvum) 		PF04200
(Lipoprotein_17) 		3 GLU A 115
HIS A 118
HIS A 119
 None
 0.87A 3co4A-2krtA:
undetectable		 3co4A-2krtA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krx ASL3597 PROTEIN

(Nostoc sp. PCC
7120) 		PF12095
(CRR7) 		3 GLU A  85
HIS A  92
HIS A  93
 None
 0.59A 3co4A-2krxA:
undetectable		 3co4A-2krxA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5y STROMAL INTERACTION
MOLECULE 2

(Homo sapiens) 		PF07647
(SAM_2) 		3 GLU A  90
HIS A 113
HIS A 118
 None
 0.94A 3co4A-2l5yA:
undetectable		 3co4A-2l5yA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8o UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF08327
(AHSA1) 		3 GLU A 138
HIS A 141
HIS A 142
 None
 0.85A 3co4A-2l8oA:
undetectable		 3co4A-2l8oA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrt UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13905
(Thioredoxin_8) 		3 GLU A 145
HIS A 151
HIS A 150
 None
 0.88A 3co4A-2lrtA:
undetectable		 3co4A-2lrtA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m47 UNCHARACTERIZED
PROTEIN CGL2373

(Corynebacterium
glutamicum) 		PF10604
(Polyketide_cyc2) 		3 GLU A 153
HIS A 162
HIS A 163
 None
 0.81A 3co4A-2m47A:
undetectable		 3co4A-2m47A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9x MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF08926
(DUF1908) 		3 GLU A  30
HIS A  47
HIS A  46
 None
 0.93A 3co4A-2m9xA:
undetectable		 3co4A-2m9xA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muy ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Escherichia
coli) 		PF06480
(FtsH_ext) 		3 GLU A  95
HIS A 100
HIS A 103
 None
 0.69A 3co4A-2muyA:
undetectable		 3co4A-2muyA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		3 GLU A  12
HIS A 119
HIS A  42
 None
 0.85A 3co4A-2q2lA:
undetectable		 3co4A-2q2lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3p UNCHARACTERIZED
PROTEIN AT3G17210

(Arabidopsis
thaliana) 		PF07876
(Dabb) 		3 GLU A  88
HIS A  86
HIS A  83
 None
 0.94A 3co4A-2q3pA:
undetectable		 3co4A-2q3pA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 GLU A 105
HIS A 516
HIS A 518
 None
 0.93A 3co4A-2qo3A:
undetectable		 3co4A-2qo3A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Bacillus
subtilis) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		3 GLU A 197
HIS A 191
HIS A 190
 None
 0.82A 3co4A-2vt2A:
undetectable		 3co4A-2vt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		3 GLU A 380
HIS A 377
HIS A 301
 None
 0.94A 3co4A-2x8uA:
undetectable		 3co4A-2x8uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 GLU A 143
HIS A 213
HIS A 189
 GYS  A  63 ( 4.8A)
None
None
 0.93A 3co4A-2zo6A:
undetectable		 3co4A-2zo6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02847
(MA3) 		3 GLU A 240
HIS B 361
HIS B 360
 None
 0.86A 3co4A-2zu6A:
undetectable		 3co4A-2zu6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 GLU A 551
HIS A 613
HIS A 609
 None
ZN  A 901 (-3.5A)
None
 0.91A 3co4A-2zzgA:
undetectable		 3co4A-2zzgA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 GLU A 118
HIS A 127
HIS A 124
 None
None
PEG  A 201 (-4.2A)
 0.69A 3co4A-3g7rA:
undetectable		 3co4A-3g7rA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		3 GLU A 227
HIS A 108
HIS A 106
 None
 0.54A 3co4A-3gv0A:
undetectable		 3co4A-3gv0A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 GLU B 556
HIS B 587
HIS B 586
 None
 0.78A 3co4A-3hhsB:
undetectable		 3co4A-3hhsB:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 GLU B 629
HIS B 637
HIS A 768
 None
 0.89A 3co4A-3hkzB:
undetectable		 3co4A-3hkzB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 GLU A 262
HIS A 294
HIS A 257
 None
 0.91A 3co4A-3hpaA:
5.9		 3co4A-3hpaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		3 GLU A 700
HIS A 584
HIS A 583
 None
 0.77A 3co4A-3i5gA:
undetectable		 3co4A-3i5gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 GLU A 147
HIS A 217
HIS A 193
 CFY  A  66 ( 4.8A)
None
None
 0.94A 3co4A-3mgfA:
undetectable		 3co4A-3mgfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]

(Taenia solium) 		PF00080
(Sod_Cu) 		3 GLU A  10
HIS A 117
HIS A  40
 None
CU  A 155 (-3.4A)
None
 0.73A 3co4A-3mndA:
undetectable		 3co4A-3mndA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfv LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 3 GLU B 558
HIS B 564
HIS B 566
 None
 0.88A 3co4A-3sfvB:
undetectable		 3co4A-3sfvB:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgn ADC OPERON REPRESSOR
ADCR

(Streptococcus
pneumoniae) 		PF01047
(MarR) 		3 GLU A 107
HIS A 109
HIS A 112
 ZN  A 148 (-2.3A)
None
ZN  A 147 (-3.2A)
 0.93A 3co4A-3tgnA:
undetectable		 3co4A-3tgnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		3 GLU B 226
HIS B 212
HIS B 211
 None
 0.89A 3co4A-3v4vB:
undetectable		 3co4A-3v4vB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a64 CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin) 		3 GLU A 404
HIS A 398
HIS A 397
 None
 0.92A 3co4A-4a64A:
undetectable		 3co4A-4a64A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		3 GLU A 166
HIS A 136
HIS A 133
 None
None
SAM  A1474 (-3.8A)
 0.89A 3co4A-4azvA:
undetectable		 3co4A-4azvA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 GLU A 847
HIS A 841
HIS A 811
 None
 0.94A 3co4A-4b56A:
undetectable		 3co4A-4b56A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4br6 SUPEROXIDE DISMUTASE

(Chaetomium
thermophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 GLU A  79
HIS A  74
HIS A  71
 None
MN3  A 301 (-3.5A)
None
 0.89A 3co4A-4br6A:
undetectable		 3co4A-4br6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		3 GLU A  42
HIS A  93
HIS A  94
 None
 0.82A 3co4A-4bvtA:
undetectable		 3co4A-4bvtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d01 NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-9

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		3 GLU A 179
HIS A 213
HIS A 215
 None
 0.88A 3co4A-4d01A:
undetectable		 3co4A-4d01A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d05 ATP-DEPENDENT DNA
LIGASE

(Psychromonas
sp. SP041) 		PF01068
(DNA_ligase_A_M)
PF14743
(DNA_ligase_OB_2) 		3 GLU A 107
HIS A 157
HIS A 158
 None
 0.64A 3co4A-4d05A:
undetectable		 3co4A-4d05A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG

(Sphingomonas
paucimobilis) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 GLU A 161
HIS A  95
HIS A  89
 None
 0.92A 3co4A-4g10A:
undetectable		 3co4A-4g10A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		3 GLU A 175
HIS A 170
HIS A 169
 None
 0.83A 3co4A-4il5A:
undetectable		 3co4A-4il5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		3 GLU A 297
HIS A 334
HIS A 331
 None
 0.94A 3co4A-4im4A:
14.4		 3co4A-4im4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		3 GLU B  76
HIS B  61
HIS B  60
 None
 0.91A 3co4A-4k3jB:
undetectable		 3co4A-4k3jB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdr 3-DEMETHYLUBIQUINONE
-9
3-METHYLTRANSFERASE

(Escherichia
coli) 		PF13489
(Methyltransf_23) 		3 GLU A  50
HIS A 236
HIS A 210
 None
 0.92A 3co4A-4kdrA:
undetectable		 3co4A-4kdrA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 GLU A 490
HIS A 663
HIS A 664
 None
 0.94A 3co4A-4mmhA:
undetectable		 3co4A-4mmhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		3 GLU A 354
HIS A 329
HIS A 332
 None
 0.78A 3co4A-4p1cA:
undetectable		 3co4A-4p1cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 3 GLU B 229
HIS B 234
HIS B 237
 None
 0.41A 3co4A-4qezB:
undetectable		 3co4A-4qezB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgl ACIREDUCTONE
DIOXYGENASE

(Bacillus
anthracis) 		PF03079
(ARD) 		3 GLU A 119
HIS A  99
HIS A 100
 None
CD  A 201 (-3.5A)
None
 0.79A 3co4A-4qglA:
undetectable		 3co4A-4qglA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 GLU A 385
HIS A 406
HIS A 407
 None
NI  A 502 ( 3.3A)
NI  A 503 ( 3.3A)
 0.91A 3co4A-4rnzA:
undetectable		 3co4A-4rnzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1
LINKER L2

(Glossoscolex
paulistus) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 GLU N  82
HIS M 126
HIS M 127
 None
 0.51A 3co4A-4u8uN:
undetectable		 3co4A-4u8uN:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 GLU A 244
HIS A 225
HIS A  83
 None
 0.74A 3co4A-4wz9A:
undetectable		 3co4A-4wz9A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2o CFA/I FIMBRIAL
SUBUNIT A
(COLONIZATION FACTOR
ANTIGEN SUBUNIT A
PUTATIVE CHAPERONE)
CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
no annotation 		3 GLU A 205
HIS B  -3
HIS B  -4
 None
NI  B 201 (-4.0A)
None
 0.81A 3co4A-4y2oA:
undetectable		 3co4A-4y2oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yio SUPEROXIDE DISMUTASE

(Streptococcus
thermophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 GLU A  85
HIS A  80
HIS A  77
 None
FE  A 301 (-3.3A)
None
 0.77A 3co4A-4yioA:
undetectable		 3co4A-4yioA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 GLU A 532
HIS A 537
HIS A 538
 None
 0.83A 3co4A-4zoyA:
undetectable		 3co4A-4zoyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 GLU A 271
HIS A 277
HIS A 188
 None
 0.91A 3co4A-5clwA:
4.7		 3co4A-5clwA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 GLU A 137
HIS A 576
HIS A 577
 None
 0.90A 3co4A-5dkxA:
4.9		 3co4A-5dkxA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 3 GLU B 613
HIS B 610
HIS B 652
 None
TSN  B2501 (-3.8A)
None
 0.71A 3co4A-5eduB:
undetectable		 3co4A-5eduB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 3 GLU B 576
HIS B 573
HIS B 615
 EDO  B 805 (-4.3A)
None
None
 0.82A 3co4A-5efnB:
undetectable		 3co4A-5efnB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 3 GLU A 385
HIS A 415
HIS A 416
 None
 0.91A 3co4A-5efvA:
undetectable		 3co4A-5efvA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		3 GLU A 275
HIS A 270
HIS A 271
 None
None
EDO  A1412 (-4.0A)
 0.94A 3co4A-5fubA:
undetectable		 3co4A-5fubA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		3 GLU A 576
HIS A 573
HIS A 615
 None
E1Z  A1801 (-3.9A)
None
 0.73A 3co4A-5g0hA:
undetectable		 3co4A-5g0hA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 GLU A 395
HIS A 388
HIS A 384
 None
 0.90A 3co4A-5gr1A:
9.1		 3co4A-5gr1A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		3 GLU A  91
HIS A 154
HIS A  84
 None
 0.89A 3co4A-5hdjA:
undetectable		 3co4A-5hdjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		3 GLU A 184
HIS A 182
HIS A 181
 None
 0.90A 3co4A-5heiA:
undetectable		 3co4A-5heiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		3 GLU A 319
HIS A 317
HIS A 314
 None
None
ZN  A 701 (-3.3A)
 0.72A 3co4A-5j47A:
undetectable		 3co4A-5j47A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk0 TYROSINE RECOMBINASE
XERH

(Helicobacter
pylori) 		PF00589
(Phage_integrase) 		3 GLU A 304
HIS A 313
HIS A 174
 None
 0.74A 3co4A-5jk0A:
undetectable		 3co4A-5jk0A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		3 GLU A 161
HIS A 368
HIS A 367
 None
 0.78A 3co4A-5lv9A:
undetectable		 3co4A-5lv9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n57 SUPEROXIDE DISMUTASE

(Staphylococcus
aureus) 		no annotation 3 GLU A  86
HIS A  81
HIS A  78
 None
MN  A 201 (-3.5A)
None
 0.85A 3co4A-5n57A:
undetectable		 3co4A-5n57A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb9 RNA CHAPERONE PROQ

(Escherichia
coli) 		PF04352
(ProQ) 		3 GLU A  33
HIS A   8
HIS A   7
 None
 0.91A 3co4A-5nb9A:
undetectable		 3co4A-5nb9A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 3 GLU A 231
HIS A  42
HIS A  44
 None
 0.82A 3co4A-5ovoA:
undetectable		 3co4A-5ovoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfk UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		no annotation 3 GLU A 134
HIS A 144
HIS A 145
 None
 0.80A 3co4A-5vfkA:
undetectable		 3co4A-5vfkA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 GLU A 511
HIS A 494
HIS A 491
 None
 0.87A 3co4A-5wu7A:
6.2		 3co4A-5wu7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU A 103
HIS A  78
HIS A 107
 None
 0.89A 3co4A-5xfmA:
10.2		 3co4A-5xfmA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 3 GLU A 304
HIS A 247
HIS A 301
 None
 0.87A 3co4A-5xomA:
undetectable		 3co4A-5xomA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 3 GLU A 167
HIS A  85
HIS A  84
 None
None
ZN  A 501 (-3.2A)
 0.89A 3co4A-5zb8A:
2.6		 3co4A-5zb8A:
14.19