SIMILAR PATTERNS OF AMINO ACIDS FOR 3CLA_A_CLMA221

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		5 ALA A 190
SER A 139
LEU A 209
VAL A 231
ILE A  45
 0GJ  A 245 (-3.4A)
None
None
None
None
 1.39A 3claA-1a5iA:
0.0		 3claA-1a5iA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		8 GLN A  92
ALA A 105
PHE A 135
ASN A 146
LEU A 160
VAL A 162
TYR A 168
ILE A 172
 None
BME  A 536 ( 4.3A)
None
None
None
None
None
None
 0.28A 3claA-1ciaA:
37.4		 3claA-1ciaA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		5 GLN A  50
ALA A  64
SER A  66
LEU A 183
ILE A 147
 None
 1.42A 3claA-1eg3A:
0.0		 3claA-1eg3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)

(Gallus gallus) 		PF00042
(Globin) 		5 GLN A  21
ALA A  18
LEU A 129
VAL A 132
ILE A 105
 None
 1.26A 3claA-1hbrA:
undetectable		 3claA-1hbrA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 PHE A 210
ASN A 408
LEU A  24
VAL A  27
ILE A 411
 None
 1.38A 3claA-1hkgA:
0.0		 3claA-1hkgA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qso HPA2 HISTONE
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		5 PHE A  46
ASN A  74
LEU A 108
VAL A  11
ILE A  73
 None
 1.41A 3claA-1qsoA:
0.0		 3claA-1qsoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		5 ALA 2  85
ASN 2 216
SER 2 219
LEU 2 132
VAL 2 142
 None
 1.36A 3claA-1rhi2:
0.0		 3claA-1rhi2:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 ALA A 292
PHE A  95
LEU A 205
VAL A 162
ILE A 233
 None
 1.37A 3claA-1rzmA:
0.0		 3claA-1rzmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		5 ALA A 102
SER A 228
LEU A 291
VAL A  77
ILE A 238
 None
PLP  A 600 (-2.5A)
None
None
None
 1.34A 3claA-1t3iA:
0.0		 3claA-1t3iA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 423
SER A 296
LEU A 414
VAL A 360
ILE A 263
 None
 1.30A 3claA-1tqyA:
0.2		 3claA-1tqyA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 ALA A 411
SER A 413
LEU A 392
VAL A 361
ILE A 370
 None
 1.26A 3claA-1vcnA:
undetectable		 3claA-1vcnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 GLN X 425
PHE X 299
LEU X 362
VAL X 360
ILE X 398
 None
 1.42A 3claA-1w52X:
undetectable		 3claA-1w52X:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 GLN A  59
ALA A  30
SER A 103
LEU A  87
ILE A  91
 None
 1.32A 3claA-2isnA:
undetectable		 3claA-2isnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 306
PHE A 339
LEU A 363
VAL A 362
ILE A  38
 None
 1.33A 3claA-2ps2A:
undetectable		 3claA-2ps2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywk PUTATIVE RNA-BINDING
PROTEIN 11

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A  33
PHE A  57
LEU A  75
VAL A  21
ILE A  80
 None
 1.28A 3claA-2ywkA:
undetectable		 3claA-2ywkA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)

(Verrillofungia
concinna) 		PF01353
(GFP) 		5 ALA A 104
PHE A  94
SER A 119
LEU A  43
VAL A 207
 None
 1.50A 3claA-2zo7A:
undetectable		 3claA-2zo7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 ALA A 288
PHE A  52
LEU A  33
VAL A 175
ILE A  20
 None
 0.86A 3claA-3bh1A:
undetectable		 3claA-3bh1A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		5 ALA A 277
ASN A  33
SER A  62
LEU A  81
ILE A  34
 None
 1.49A 3claA-3d02A:
undetectable		 3claA-3d02A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 ALA A 109
SER A 120
LEU A   8
TYR A  42
ILE A   6
 None
 1.40A 3claA-3gboA:
undetectable		 3claA-3gboA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ALA A 437
ASN A 398
LEU A 361
VAL A 369
ILE A 395
 None
 1.36A 3claA-3ifqA:
undetectable		 3claA-3ifqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		5 ALA A 235
PHE A 236
LEU A 271
VAL A 413
ILE A 264
 None
 1.47A 3claA-3iuyA:
undetectable		 3claA-3iuyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 GLN A 745
ASN A 717
LEU A 761
TYR A 737
ILE A 720
 None
 1.25A 3claA-3nawA:
undetectable		 3claA-3nawA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 ALA A 292
PHE A  95
LEU A 205
VAL A 162
ILE A 233
 None
 1.30A 3claA-3pg8A:
undetectable		 3claA-3pg8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 ALA A 274
PHE A 327
SER A 167
LEU A  97
ILE A 291
 None
 1.19A 3claA-3q3qA:
undetectable		 3claA-3q3qA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		5 GLN A 109
ASN A 132
LEU A  10
VAL A  17
ILE A 160
 CL  A 270 (-3.8A)
None
None
None
None
 1.49A 3claA-3stgA:
undetectable		 3claA-3stgA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjr SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 ALA A  78
PHE A  82
LEU A 174
VAL A 178
ILE A 142
 None
 1.34A 3claA-3tjrA:
undetectable		 3claA-3tjrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		5 GLN A 344
LEU A 355
VAL A 358
TYR A 339
ILE A 341
 None
 1.27A 3claA-3votA:
undetectable		 3claA-3votA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 PHE A 199
LEU A 283
VAL A 214
TYR A 292
ILE A 290
 None
 1.34A 3claA-4bjuA:
undetectable		 3claA-4bjuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ALA A 183
SER A 186
LEU A 158
TYR A 146
ILE A 193
 None
 1.40A 3claA-4cvqA:
undetectable		 3claA-4cvqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		5 GLN A 184
ALA A  88
LEU A 201
VAL A 202
ILE A 191
 None
 0.99A 3claA-4dkbA:
undetectable		 3claA-4dkbA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ALA A  45
PHE A 306
VAL A 264
TYR A 381
ILE A 254
 None
 1.41A 3claA-4eyoA:
undetectable		 3claA-4eyoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 PHE A 538
SER A 583
LEU A 649
VAL A 651
ILE A 641
 None
 1.39A 3claA-4f9oA:
undetectable		 3claA-4f9oA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00303
(Thymidylat_synt) 		5 GLN A 165
ALA A 168
LEU A  45
VAL A  50
ILE A 178
 UFP  A 301 (-4.1A)
UFP  A 301 ( 4.9A)
None
None
None
 1.17A 3claA-4fogA:
undetectable		 3claA-4fogA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ALA A  83
SER A 221
LEU A 200
VAL A 204
ILE A 229
 None
 1.02A 3claA-4h1sA:
undetectable		 3claA-4h1sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		5 GLN B 151
PHE B 158
ASN B  78
VAL B  63
ILE B  81
 None
 1.23A 3claA-4lfnB:
undetectable		 3claA-4lfnB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		5 GLN A  91
ASN A  95
LEU A 199
VAL A 108
ILE A 211
 None
 1.31A 3claA-4tzoA:
undetectable		 3claA-4tzoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		5 GLN A 241
ALA A 262
ASN A 171
LEU A 208
ILE A 170
 EDO  A1631 (-3.8A)
EDO  A1631 (-3.2A)
EDO  A1631 (-4.4A)
None
None
 1.35A 3claA-4ut1A:
undetectable		 3claA-4ut1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		5 ALA A 204
PHE A 173
SER A   6
VAL A 104
ILE A   9
 None
 1.00A 3claA-4xkyA:
undetectable		 3claA-4xkyA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ALA A 266
ASN A 447
LEU A 782
VAL A 777
ILE A 645
 None
 1.31A 3claA-4zktA:
undetectable		 3claA-4zktA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA E 190
SER E 139
LEU E 209
VAL E 231
ILE E  45
 None
 1.27A 3claA-5brrE:
undetectable		 3claA-5brrE:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		5 GLN A 170
ALA A 167
PHE A 224
LEU A 189
VAL A 247
 None
 1.28A 3claA-5bu9A:
undetectable		 3claA-5bu9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ALA C 217
PHE C 158
SER C 499
LEU C 510
ILE C 514
 None
None
None
None
EDO  C1576 ( 4.2A)
 1.45A 3claA-5fseC:
undetectable		 3claA-5fseC:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvq SPLICING FACTOR 3B
SUBUNIT 4

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A  39
PHE A  64
LEU A  82
VAL A  27
ILE A  87
 None
 1.28A 3claA-5gvqA:
undetectable		 3claA-5gvqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis) 		PF00303
(Thymidylat_synt) 		5 GLN A 216
ALA A 219
LEU A  46
VAL A  51
ILE A 229
 None
 1.16A 3claA-5j7wA:
undetectable		 3claA-5j7wA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxr RNA-BINDING PROTEIN
7

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A  33
PHE A  57
LEU A  75
VAL A  21
ILE A  80
 None
 1.23A 3claA-5lxrA:
undetectable		 3claA-5lxrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN

(Homo sapiens) 		PF16690
(MMACHC) 		5 ALA A 120
PHE A  26
LEU A  87
VAL A  90
ILE A 101
 None
None
171  A 304 ( 3.7A)
None
171  A 304 (-4.4A)
 1.37A 3claA-5uosA:
undetectable		 3claA-5uosA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 241
SER A 191
LEU A  65
VAL A  31
ILE A 216
 None
 1.18A 3claA-5wrpA:
undetectable		 3claA-5wrpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 ALA A 118
ASN A 334
LEU A   9
VAL A  13
ILE A   7
 None
 1.42A 3claA-5wwtA:
undetectable		 3claA-5wwtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 GLN A 720
PHE A 745
LEU A 681
VAL A 677
ILE A 687
 None
 1.11A 3claA-5y4fA:
undetectable		 3claA-5y4fA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 5 GLN A 201
ALA A 184
PHE A 185
LEU A 136
VAL A 140
 None
 1.15A 3claA-6cv9A:
undetectable		 3claA-6cv9A:
undetectable