SIMILAR PATTERNS OF AMINO ACIDS FOR 3CL9_A_MTXA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 345
ARG A  72
ILE A 152
THR A 188
 None
 0.99A 3cl9A-1b3bA:
0.0		 3cl9A-1b3bA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		4 VAL A   6
ARG A  32
ILE A  51
THR A 121
 None
 0.77A 3cl9A-1cz3A:
18.3		 3cl9A-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 VAL C 116
ARG C 107
ILE C 146
THR B 265
 None
 1.24A 3cl9A-1e6vC:
undetectable		 3cl9A-1e6vC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 VAL A  14
ARG A 130
ILE A 191
THR A  16
 None
 1.41A 3cl9A-1e6wA:
1.4		 3cl9A-1e6wA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 155
ARG A  36
ILE A  33
THR A 290
 None
 1.25A 3cl9A-1g0dA:
undetectable		 3cl9A-1g0dA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		4 VAL A 341
ARG A 402
ILE A 266
THR A 339
 None
 1.02A 3cl9A-1g38A:
0.8		 3cl9A-1g38A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A 265
ARG A 307
ILE A 252
THR A  43
 None
 1.18A 3cl9A-1hskA:
undetectable		 3cl9A-1hskA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 VAL A 296
ARG A 225
ILE A 202
THR A 266
 None
DHE  A 602 (-3.5A)
None
None
 1.24A 3cl9A-1hzvA:
undetectable		 3cl9A-1hzvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is1 RIBOSOME RECYCLING
FACTOR

(Vibrio
parahaemolyticus) 		PF01765
(RRF) 		4 VAL A  27
ARG A 118
ILE A 171
THR A  29
 None
 1.37A 3cl9A-1is1A:
undetectable		 3cl9A-1is1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		4 VAL A 161
ARG A 262
ILE A 303
THR A 159
 None
 1.30A 3cl9A-1jcfA:
undetectable		 3cl9A-1jcfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 VAL T 172
ARG T 156
ILE T 176
THR T 165
 None
 1.38A 3cl9A-1lthT:
undetectable		 3cl9A-1lthT:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 175
ARG A 166
ILE A 183
THR A 263
 None
None
NAD  A 400 (-3.8A)
None
 0.97A 3cl9A-1pl8A:
2.4		 3cl9A-1pl8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 384
ARG A 534
ILE A 538
THR A 422
 None
 1.43A 3cl9A-1pvdA:
undetectable		 3cl9A-1pvdA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL 3  49
ARG 1 252
ILE 1  67
THR 3  51
 None
 1.28A 3cl9A-1r1a3:
undetectable		 3cl9A-1r1a3:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 VAL A 372
ARG A 248
ILE A 401
THR A 367
 None
 1.05A 3cl9A-1ry2A:
undetectable		 3cl9A-1ry2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryl HYPOTHETICAL PROTEIN
YFBM

(Escherichia
coli) 		PF08974
(DUF1877) 		4 VAL A  71
ARG A  45
ILE A 122
THR A 163
 None
 1.21A 3cl9A-1rylA:
undetectable		 3cl9A-1rylA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v30 HYPOTHETICAL UPF0131
PROTEIN PH0828

(Pyrococcus
horikoshii) 		PF06094
(GGACT) 		4 VAL A  86
ARG A  17
ILE A  72
THR A  88
 None
 1.26A 3cl9A-1v30A:
undetectable		 3cl9A-1v30A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 VAL A 907
ARG A 918
ILE A 932
THR A 938
 None
 1.42A 3cl9A-1vrqA:
undetectable		 3cl9A-1vrqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xat XENOBIOTIC
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep) 		4 VAL A 129
ARG A  45
ILE A  65
THR A 144
 None
 1.41A 3cl9A-1xatA:
undetectable		 3cl9A-1xatA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		4 VAL A 216
ARG A  29
ILE A  32
THR A 374
 None
 1.30A 3cl9A-1ybeA:
undetectable		 3cl9A-1ybeA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		4 VAL A 251
ARG A 267
ILE A   2
THR A 253
 None
 1.36A 3cl9A-1ycoA:
undetectable		 3cl9A-1ycoA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 VAL A 343
ARG A 334
ILE A 327
THR A 316
 None
None
ATP  A1001 (-4.1A)
None
 1.25A 3cl9A-1z7eA:
undetectable		 3cl9A-1z7eA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		4 VAL A  72
ARG A 167
ILE A 182
THR A  74
 None
 1.27A 3cl9A-2a5vA:
undetectable		 3cl9A-2a5vA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		4 VAL A 103
ARG A 187
ILE A 193
THR A 108
 MC3  A 265 (-4.1A)
None
MC3  A 270 (-4.0A)
None
 1.25A 3cl9A-2b6oA:
undetectable		 3cl9A-2b6oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 VAL A 163
ARG A 114
ILE A 199
THR A 161
 None
 1.29A 3cl9A-2bhmA:
undetectable		 3cl9A-2bhmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		4 VAL A 498
ARG A 517
ILE A 536
THR A 639
 None
 1.42A 3cl9A-2c79A:
undetectable		 3cl9A-2c79A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 VAL A 867
ARG A 837
ILE A 850
THR A 885
 None
 1.22A 3cl9A-2eaeA:
undetectable		 3cl9A-2eaeA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		4 VAL A 352
ARG A 139
ILE A 317
THR A 356
 None
 1.05A 3cl9A-2g85A:
undetectable		 3cl9A-2g85A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		4 VAL A 239
ARG A 302
ILE A 259
THR A 199
 None
 1.11A 3cl9A-2gnoA:
undetectable		 3cl9A-2gnoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 127
ARG A  47
ILE A 101
THR A  27
 None
 1.39A 3cl9A-2gskA:
undetectable		 3cl9A-2gskA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 VAL A  26
ARG A  53
ILE A  84
THR A 178
 None
 0.29A 3cl9A-2h2qA:
51.1		 3cl9A-2h2qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsj PUTATIVE PLATELET
ACTIVATING FACTOR

(Streptococcus
pneumoniae) 		PF13472
(Lipase_GDSL_2) 		4 VAL A 115
ARG A  60
ILE A  90
THR A 122
 None
None
None
GOL  A1409 (-3.8A)
 0.99A 3cl9A-2hsjA:
undetectable		 3cl9A-2hsjA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in2 PICORNAIN 3C

(Rhinovirus B) 		PF00548
(Peptidase_C3) 		4 VAL A 161
ARG A 133
ILE A 124
THR A  39
 None
 0.83A 3cl9A-2in2A:
undetectable		 3cl9A-2in2A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7m HYALURONIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 VAL A 765
ARG A 740
ILE A 698
THR A 628
 None
 1.19A 3cl9A-2j7mA:
undetectable		 3cl9A-2j7mA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		4 VAL A  89
ARG A 225
ILE A 241
THR A 136
 None
 1.08A 3cl9A-2jahA:
1.7		 3cl9A-2jahA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poi BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00653
(BIR) 		4 VAL A  61
ARG A  49
ILE A  93
THR A  32
 None
 1.19A 3cl9A-2poiA:
undetectable		 3cl9A-2poiA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 160
ARG A  35
ILE A 136
THR A 295
 None
 1.26A 3cl9A-2q3zA:
undetectable		 3cl9A-2q3zA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 VAL A 261
ARG A 272
ILE A 378
THR A 288
 None
 1.38A 3cl9A-2q9uA:
undetectable		 3cl9A-2q9uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		4 VAL A 107
ARG A 171
ILE A 160
THR A 127
 None
 1.16A 3cl9A-2uyoA:
undetectable		 3cl9A-2uyoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 160
ARG A  11
ILE A  17
THR A 135
 VAL  A 160 ( 0.6A)
ARG  A  11 ( 0.6A)
ILE  A  17 ( 0.7A)
THR  A 135 ( 0.8A)
 1.29A 3cl9A-2vbfA:
undetectable		 3cl9A-2vbfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 VAL D 568
ARG D 688
ILE D 636
THR D 843
 None
None
None
A  B  -2 ( 3.2A)
 1.28A 3cl9A-2vnuD:
undetectable		 3cl9A-2vnuD:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 VAL D 577
ARG D 590
ILE D 884
THR D 581
 None
 1.33A 3cl9A-2vnuD:
undetectable		 3cl9A-2vnuD:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 VAL J 577
ARG J 590
ILE J 884
THR J 581
 None
 1.32A 3cl9A-2wp8J:
2.2		 3cl9A-2wp8J:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 VAL A 460
ARG A 121
ILE A 114
THR A 490
 None
 1.41A 3cl9A-3dh4A:
undetectable		 3cl9A-3dh4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 VAL A 240
ARG A 288
ILE A 293
THR A 242
 None
 1.06A 3cl9A-3e53A:
0.7		 3cl9A-3e53A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 VAL A  58
ARG A  45
ILE A  63
THR A 385
 None
 0.79A 3cl9A-3ei8A:
undetectable		 3cl9A-3ei8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et6 SOLUBLE GUANYLYL
CYCLASE BETA

(Chlamydomonas
reinhardtii) 		PF00211
(Guanylate_cyc) 		4 VAL A 531
ARG A 552
ILE A 570
THR A 477
 None
 1.24A 3cl9A-3et6A:
undetectable		 3cl9A-3et6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 VAL A  31
ARG A 286
ILE A 164
THR A  33
 None
 1.36A 3cl9A-3g7tA:
undetectable		 3cl9A-3g7tA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1d BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00653
(BIR) 		4 VAL A  81
ARG A  69
ILE A 113
THR A  52
 None
 1.22A 3cl9A-3m1dA:
undetectable		 3cl9A-3m1dA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		4 VAL A  71
ARG A  45
ILE A  80
THR B 456
 None
 1.26A 3cl9A-3ml0A:
undetectable		 3cl9A-3ml0A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 VAL A   7
ARG A 464
ILE A  12
THR A 445
 None
 1.40A 3cl9A-3nksA:
undetectable		 3cl9A-3nksA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 VAL A 127
ARG A  29
ILE A  64
THR A 125
 None
SO4  A 435 (-4.0A)
None
None
 1.34A 3cl9A-3nwrA:
undetectable		 3cl9A-3nwrA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 VAL A  48
ARG A  35
ILE A 116
THR A  44
 None
PO4  A 766 (-4.4A)
None
None
 1.22A 3cl9A-3o8lA:
undetectable		 3cl9A-3o8lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 VAL A 310
ARG A 211
ILE A 420
THR A 200
 None
 1.35A 3cl9A-3p1vA:
undetectable		 3cl9A-3p1vA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 VAL A  47
ARG A 162
ILE A 146
THR A  57
 None
 1.38A 3cl9A-3py6A:
undetectable		 3cl9A-3py6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 VAL A  15
ARG A  40
ILE A  46
THR A  30
 None
 1.35A 3cl9A-3ssmA:
2.8		 3cl9A-3ssmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		4 VAL A 412
ARG A 444
ILE A 582
THR A 393
 None
 1.39A 3cl9A-3tbfA:
undetectable		 3cl9A-3tbfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF00106
(adh_short) 		4 VAL A   9
ARG A 119
ILE A 182
THR A  11
 None
 1.33A 3cl9A-3tl3A:
undetectable		 3cl9A-3tl3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 VAL A3267
ARG A3620
ILE A3238
THR A3189
 None
 0.95A 3cl9A-3vkgA:
undetectable		 3cl9A-3vkgA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 VAL A 587
ARG A 571
ILE A 537
THR A 584
 None
MPD  A1207 ( 4.1A)
None
None
 1.39A 3cl9A-3w5nA:
undetectable		 3cl9A-3w5nA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 VAL A  78
ARG A 102
ILE A 389
THR A  73
 None
 1.40A 3cl9A-3w6mA:
undetectable		 3cl9A-3w6mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv7 HMD CO-OCCURRING
PROTEIN HCGE

(Methanothermobacter
marburgensis) 		PF00899
(ThiF) 		4 VAL A 175
ARG A  27
ILE A 109
THR A 177
 None
None
ADP  A 301 (-3.8A)
None
 1.33A 3cl9A-3wv7A:
undetectable		 3cl9A-3wv7A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		4 VAL A  59
ARG A  81
ILE A  87
THR A  70
 None
 1.06A 3cl9A-3wwxA:
undetectable		 3cl9A-3wwxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 VAL A 311
ARG A 405
ILE A 269
THR A 355
 None
 1.01A 3cl9A-4au2A:
undetectable		 3cl9A-4au2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		4 VAL A 273
ARG A 328
ILE A 198
THR A 249
 None
 1.30A 3cl9A-4bomA:
undetectable		 3cl9A-4bomA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chh PROTEIN INTERACTING
WITH HSP90 1

(Saccharomyces
cerevisiae) 		PF08190
(PIH1) 		4 VAL A  63
ARG A 153
ILE A 134
THR A  96
 None
 1.42A 3cl9A-4chhA:
undetectable		 3cl9A-4chhA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A 243
ARG A 173
ILE A 178
THR A 245
 None
 1.24A 3cl9A-4hu2A:
undetectable		 3cl9A-4hu2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 268
ARG A 304
ILE A 290
THR A 271
 None
 1.27A 3cl9A-4hzzA:
undetectable		 3cl9A-4hzzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 VAL A 559
ARG A 637
ILE A 631
THR A 592
 None
 1.23A 3cl9A-4k0eA:
undetectable		 3cl9A-4k0eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394

(Burkholderia
cenocepacia) 		PF02545
(Maf) 		4 VAL A 131
ARG A 147
ILE A 196
THR A  69
 None
PO4  A 303 (-4.0A)
EDO  A 306 (-4.9A)
None
 1.33A 3cl9A-4oo0A:
undetectable		 3cl9A-4oo0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 VAL A 403
ARG A 339
ILE A 322
THR A 399
 None
FAD  A2001 (-4.0A)
None
FAD  A2001 ( 4.6A)
 1.30A 3cl9A-4q73A:
2.5		 3cl9A-4q73A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 VAL A 459
ARG A 352
ILE A 349
THR A 456
 None
 1.09A 3cl9A-4rcnA:
undetectable		 3cl9A-4rcnA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		4 VAL A 238
ARG A  93
ILE A 210
THR A 243
 None
HEM  A 401 (-3.9A)
None
HEM  A 401 (-3.7A)
 1.39A 3cl9A-4rm4A:
undetectable		 3cl9A-4rm4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv6 APICAL MEROZOITE
ANTIGEN 1

(Plasmodium
knowlesi) 		PF02430
(AMA-1) 		4 VAL A 114
ARG A 317
ILE A 135
THR A 116
 None
 1.11A 3cl9A-4uv6A:
undetectable		 3cl9A-4uv6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 VAL A 144
ARG A 122
ILE A  74
THR A 177
 None
 1.23A 3cl9A-4w8xA:
undetectable		 3cl9A-4w8xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 VAL A  48
ARG A 281
ILE A 248
THR A 262
 None
 1.00A 3cl9A-4yfmA:
undetectable		 3cl9A-4yfmA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 VAL A 222
ARG A 102
ILE A  79
THR A 108
 None
 1.31A 3cl9A-4yj1A:
undetectable		 3cl9A-4yj1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A 487
ARG A   9
ILE A 462
THR A 439
 MCN  A 801 (-3.8A)
None
None
None
 1.23A 3cl9A-4zohA:
undetectable		 3cl9A-4zohA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus) 		PF13472
(Lipase_GDSL_2) 		4 VAL A  34
ARG A  18
ILE A 125
THR A  26
 None
 1.32A 3cl9A-5b5sA:
undetectable		 3cl9A-5b5sA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 182
ARG A 176
ILE A 196
THR A 145
 None
None
None
M2A  A 501 (-3.5A)
 1.34A 3cl9A-5elxA:
1.7		 3cl9A-5elxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 VAL A 238
ARG A 180
ILE A 174
THR A 261
 None
 1.27A 3cl9A-5ereA:
undetectable		 3cl9A-5ereA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 VAL A1546
ARG A1663
ILE A1614
THR A1769
 None
 1.39A 3cl9A-5i6gA:
undetectable		 3cl9A-5i6gA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 VAL A1546
ARG A1663
ILE A1614
THR A1769
 None
 1.37A 3cl9A-5i6hA:
undetectable		 3cl9A-5i6hA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 VAL A1546
ARG A1663
ILE A1614
THR A1769
 None
 1.27A 3cl9A-5i6iA:
undetectable		 3cl9A-5i6iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzl HEME OXYGENASE

(Leptospira
interrogans) 		PF01126
(Heme_oxygenase) 		4 VAL A 124
ARG A 106
ILE A 201
THR A  11
 HEM  A 301 (-4.4A)
None
None
None
 1.32A 3cl9A-5kzlA:
undetectable		 3cl9A-5kzlA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1w P2X PURINOCEPTOR

(Ailuropoda
melanoleuca) 		PF00864
(P2X_receptor) 		4 VAL A 104
ARG A 230
ILE A 254
THR A 106
 None
 1.28A 3cl9A-5u1wA:
undetectable		 3cl9A-5u1wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 VAL A  89
ARG A  25
ILE A  51
THR A 139
 None
None
None
NAP  A 301 ( 3.8A)
 1.19A 3cl9A-5u2wA:
1.8		 3cl9A-5u2wA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A

(Francisella
tularensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 VAL A  62
ARG C  88
ILE C 144
THR A  57
 None
 1.03A 3cl9A-5u56A:
undetectable		 3cl9A-5u56A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 VAL A 632
ARG A 555
ILE A 679
THR A 711
 None
 1.26A 3cl9A-5ur2A:
3.0		 3cl9A-5ur2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12

(Schizosaccharomyces
pombe) 		no annotation 4 VAL M 186
ARG M 201
ILE M 151
THR M 192
 None
 1.43A 3cl9A-5wwlM:
undetectable		 3cl9A-5wwlM:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 4 VAL A 416
ARG A 362
ILE A 365
THR A 407
 None
PQQ  A 701 (-2.8A)
None
None
 1.15A 3cl9A-5xm3A:
undetectable		 3cl9A-5xm3A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 VAL B 780
ARG B 815
ILE B 755
THR B 783
 None
 1.43A 3cl9A-5xogB:
undetectable		 3cl9A-5xogB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 4 VAL A   6
ARG A 224
ILE A 237
THR A  22
 None
 1.42A 3cl9A-5xxgA:
undetectable		 3cl9A-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S14

(Trichomonas
vaginalis) 		PF00411
(Ribosomal_S11) 		4 VAL O  50
ARG O 125
ILE O 137
THR O  48
 None
 0.89A 3cl9A-5xyiO:
undetectable		 3cl9A-5xyiO:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 4 VAL A  94
ARG A  87
ILE A 112
THR A  67
 None
 1.35A 3cl9A-5yeqA:
undetectable		 3cl9A-5yeqA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 171
ARG A 205
ILE A 199
THR A 169
 None
 1.29A 3cl9A-6aooA:
undetectable		 3cl9A-6aooA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 4 VAL A 468
ARG A 376
ILE A 330
THR A 464
 None
 1.03A 3cl9A-6b4hA:
undetectable		 3cl9A-6b4hA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 4 VAL B 735
ARG B 770
ILE B 710
THR B 738
 None
 1.37A 3cl9A-6exvB:
undetectable		 3cl9A-6exvB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1v CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		no annotation 4 VAL f 644
ARG f 704
ILE f 764
THR f 695
 None
 1.39A 3cl9A-6f1vf:
undetectable		 3cl9A-6f1vf:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL
ATP SYNTHASE GAMMA
SUBUNIT
ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 VAL A 289
ARG D 279
ILE G 277
THR D 329
 None
 1.23A 3cl9A-6f5dA:
undetectable		 3cl9A-6f5dA:
10.10