SIMILAR PATTERNS OF AMINO ACIDS FOR 3CE6_C_ADNC500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE


(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
4 GLN A 212
THR A 209
THR A 140
HIS A  77
None
None
None
ZN  A 500 (-3.4A)
1.14A 3ce6C-1ddkA:
2.3
3ce6C-1ddkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN B 210
THR B 173
THR B 492
LEU B 507
None
1.32A 3ce6C-1e9yB:
2.0
3ce6C-1e9yB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iie PROTEIN (HLA-DR
ANTIGENS ASSOCIATED
INVARIANT CHAIN)


(Homo sapiens)
PF08831
(MHCassoc_trimer)
4 GLN A 131
THR A 156
HIS A 152
LEU A 142
None
1.24A 3ce6C-1iieA:
undetectable
3ce6C-1iieA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE


([Clostridium]
symbiosum)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
4 GLN A 293
THR A 292
THR A 453
LEU A 396
None
1.31A 3ce6C-1kblA:
2.3
3ce6C-1kblA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN


(Salmonella
enterica)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N)
4 GLN A 158
THR A 161
THR A 110
LEU A 103
None
1.23A 3ce6C-1pemA:
undetectable
3ce6C-1pemA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I


(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
4 GLN A 293
THR A 292
THR A 356
LEU A 349
None
1.28A 3ce6C-1q2eA:
undetectable
3ce6C-1q2eA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujj ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1


(Homo sapiens)
PF00790
(VHS)
4 GLN A  36
THR A   9
THR A  18
LEU A  51
None
1.23A 3ce6C-1ujjA:
undetectable
3ce6C-1ujjA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus)
PF00232
(Glyco_hydro_1)
4 THR A 386
THR A 203
HIS A 243
LEU A 314
None
1.34A 3ce6C-1uwiA:
undetectable
3ce6C-1uwiA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvi PUTATIVE
PHOSPHATASES
INVOLVED IN
N-ACETYL-GLUCOSAMINE
CATABOLISM


(Streptococcus
mutans)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 GLN A1053
THR A1064
THR A1042
LEU A1074
None
1.30A 3ce6C-1wviA:
2.7
3ce6C-1wviA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum)
PF00378
(ECH_1)
4 GLN A 220
THR A 221
THR A 148
LEU A  91
None
1.12A 3ce6C-2a81A:
undetectable
3ce6C-2a81A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli)
PF01144
(CoA_trans)
4 GLN A 362
THR A 334
THR A 399
LEU A 376
None
None
None
COA  A2600 (-4.9A)
1.37A 3ce6C-2ahwA:
undetectable
3ce6C-2ahwA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE


(Pyrococcus
furiosus)
PF01380
(SIS)
4 THR A 290
THR A 222
HIS A 250
LEU A 266
None
1.14A 3ce6C-2cb0A:
2.3
3ce6C-2cb0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1


(Saccharomyces
cerevisiae)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
4 THR A 608
THR A 204
HIS A 200
LEU A 481
None
1.15A 3ce6C-2cvtA:
undetectable
3ce6C-2cvtA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE


(Escherichia
coli)
PF13561
(adh_short_C2)
4 GLN X 113
THR X 114
THR X 128
LEU X 154
None
1.36A 3ce6C-2fwmX:
8.2
3ce6C-2fwmX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN


(Clytia gregaria)
PF01353
(GFP)
4 GLN A  89
THR A  88
HIS A 200
LEU A 202
None
1.07A 3ce6C-2hpwA:
undetectable
3ce6C-2hpwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 GLN A 333
THR A 107
THR A 383
HIS A 414
GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
1.11A 3ce6C-2nvvA:
undetectable
3ce6C-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR


(Mus musculus)
no annotation 4 GLN X 275
THR X 277
THR X 306
HIS X 222
None
1.28A 3ce6C-2o26X:
undetectable
3ce6C-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6


(Homo sapiens)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
4 THR B 750
THR B1142
HIS B1096
LEU B1149
None
1.31A 3ce6C-2o8eB:
undetectable
3ce6C-2o8eB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q07 UNCHARACTERIZED
PROTEIN AF0587


(Archaeoglobus
fulgidus)
PF01472
(PUA)
4 THR A 350
THR A 267
HIS A 278
LEU A 281
None
1.34A 3ce6C-2q07A:
undetectable
3ce6C-2q07A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
4 GLN A 246
THR A 265
HIS A 319
LEU A 301
None
ADE  A 488 (-4.3A)
None
None
1.37A 3ce6C-2qluA:
undetectable
3ce6C-2qluA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ


(Bacteroides
fragilis)
PF00884
(Sulfatase)
4 GLN A 380
THR A 378
HIS A 164
LEU A 109
None
1.08A 3ce6C-2qzuA:
undetectable
3ce6C-2qzuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 GLN A 147
THR A 291
HIS A 156
LEU A 155
None
1.32A 3ce6C-2w4oA:
undetectable
3ce6C-2w4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE


(Rhodobacter
capsulatus)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 GLN B 232
THR B 516
HIS B 483
LEU B 492
HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
1.24A 3ce6C-2w55B:
undetectable
3ce6C-2w55B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
4 GLN A 330
THR A 477
HIS A 339
LEU A 338
None
1.26A 3ce6C-2xk9A:
undetectable
3ce6C-2xk9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE


(Infectious
pancreatic
necrosis virus)
PF04197
(Birna_RdRp)
4 THR A 733
THR A 411
HIS A 414
LEU A 482
None
1.32A 3ce6C-2yiaA:
undetectable
3ce6C-2yiaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD)
4 GLN A 575
THR A 720
HIS A 613
LEU A 638
None
None
ZN  A 901 (-3.5A)
None
1.26A 3ce6C-2zzgA:
undetectable
3ce6C-2zzgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
4 GLN A  60
THR A 114
HIS A 104
LEU A  28
None
1.35A 3ce6C-3bqyA:
undetectable
3ce6C-3bqyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida)
PF03349
(Toluene_X)
4 THR A   1
THR A  55
HIS A 420
LEU A 374
None
1.38A 3ce6C-3brzA:
undetectable
3ce6C-3brzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2

(Rhinovirus A)
PF00073
(Rhv)
4 THR B  70
THR B 233
HIS B 118
LEU B 194
None
1.37A 3ce6C-3dprB:
undetectable
3ce6C-3dprB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE


(Cytophaga
hutchinsonii)
PF00682
(HMGL-like)
4 THR A 211
THR A 259
HIS A 263
LEU A 266
None
1.04A 3ce6C-3eegA:
undetectable
3ce6C-3eegA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
NAD  A 439 ( 4.0A)
0.24A 3ce6C-3g1uA:
54.0
3ce6C-3g1uA:
54.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  66
THR A  67
THR A 200
HIS A 344
LEU A 385
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
NAD  A 601 ( 4.1A)
0.24A 3ce6C-3glqA:
59.1
3ce6C-3glqA:
57.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
0.56A 3ce6C-3h9uA:
56.1
3ce6C-3h9uA:
56.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
4 GLN A 335
THR A 337
THR A 294
LEU A 287
None
1.28A 3ce6C-3i45A:
5.8
3ce6C-3i45A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE


(Aspergillus
fumigatus)
PF11991
(Trp_DMAT)
4 GLN A 343
THR A 348
HIS A 396
LEU A 360
DST  A 460 (-3.1A)
None
None
None
1.21A 3ce6C-3i4xA:
undetectable
3ce6C-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im7 CARDIAC CA2+ RELEASE
CHANNEL


(Mus musculus)
PF08709
(Ins145_P3_rec)
4 GLN A  33
THR A  27
THR A 210
HIS A 193
None
1.34A 3ce6C-3im7A:
undetectable
3ce6C-3im7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING


(Thermotoga
maritima)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLN A  74
THR A  75
THR A  87
LEU A  93
None
1.28A 3ce6C-3ip1A:
10.3
3ce6C-3ip1A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE


(Aphonopelma)
PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N)
4 GLN A 219
THR A 220
THR A 446
LEU A 255
None
1.27A 3ce6C-3jbhA:
undetectable
3ce6C-3jbhA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhh CBS DOMAIN PROTEIN

(Shewanella
oneidensis)
PF00571
(CBS)
4 GLN A 154
THR A 133
HIS A 129
LEU A 126
None
1.33A 3ce6C-3lhhA:
undetectable
3ce6C-3lhhA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)


(Bacillus
licheniformis)
PF07451
(SpoVAD)
4 GLN A 215
THR A 186
THR A 307
LEU A 243
None
1.30A 3ce6C-3lmaA:
undetectable
3ce6C-3lmaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE


(Rickettsia
prowazekii)
PF00557
(Peptidase_M24)
4 THR A  28
THR A 106
HIS A 234
LEU A 248
None
1.17A 3ce6C-3mr1A:
undetectable
3ce6C-3mr1A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  59
THR A  60
THR A 193
HIS A 337
LEU A 378
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
NAD  A 550 (-4.3A)
0.27A 3ce6C-3n58A:
59.2
3ce6C-3n58A:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5b ASR0485 PROTEIN

(Nostoc sp. PCC
7120)
PF12058
(DUF3539)
4 GLN B  37
THR B  14
HIS B  12
LEU B  18
None
1.36A 3ce6C-3n5bB:
undetectable
3ce6C-3n5bB:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nok GLUTAMINYL CYCLASE

(Myxococcus
xanthus)
PF05096
(Glu_cyclase_2)
4 GLN A  98
THR A 240
HIS A  39
LEU A  68
None
1.24A 3ce6C-3nokA:
undetectable
3ce6C-3nokA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN


(Escherichia
coli)
PF00496
(SBP_bac_5)
4 THR A 316
THR A 429
HIS A 432
LEU A 115
None
1.31A 3ce6C-3o9pA:
undetectable
3ce6C-3o9pA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA


(Escherichia
coli)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
4 GLN D 268
THR D 270
HIS D 110
LEU D 221
None
1.33A 3ce6C-3oaaD:
undetectable
3ce6C-3oaaD:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  66
THR A  67
THR A 206
HIS A 350
LEU A 395
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.2A)
0.45A 3ce6C-3oneA:
58.7
3ce6C-3oneA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)


(Mycobacterium
tuberculosis)
PF00857
(Isochorismatase)
4 GLN A 141
THR A 142
THR A 160
LEU A 182
None
1.34A 3ce6C-3pl1A:
2.6
3ce6C-3pl1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2


(Helicobacter
mustelae)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN C 209
THR C 172
THR C 491
LEU C 506
None
1.32A 3ce6C-3qgkC:
undetectable
3ce6C-3qgkC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr5 CARDIAC CA2+ RELEASE
CHANNEL


(Mus musculus)
PF08709
(Ins145_P3_rec)
4 GLN A  33
THR A  27
THR A 210
HIS A 193
None
1.08A 3ce6C-3qr5A:
undetectable
3ce6C-3qr5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF00092
(VWA)
4 THR A  84
THR A   6
HIS A 133
LEU A 222
None
1.14A 3ce6C-3ragA:
4.2
3ce6C-3ragA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122


(Staphylococcus
aureus)
PF00171
(Aldedh)
4 THR A 222
THR A 150
HIS A 103
LEU A  92
None
1.20A 3ce6C-3ty7A:
2.2
3ce6C-3ty7A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1


(Homo sapiens)
PF00079
(Serpin)
4 THR A  93
THR A 369
HIS A 364
LEU A 233
None
1.16A 3ce6C-3ut3A:
undetectable
3ce6C-3ut3A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE


(Glycine max)
PF00291
(PALP)
4 GLN A 331
THR A  74
THR A 342
HIS A 344
None
1.35A 3ce6C-3vbeA:
4.7
3ce6C-3vbeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis)
PF00561
(Abhydrolase_1)
4 THR A 100
THR A   3
HIS A  37
LEU A  32
None
1.28A 3ce6C-3w9uA:
2.6
3ce6C-3w9uA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 THR A 594
THR A 653
HIS A 603
LEU A 616
None
1.25A 3ce6C-4c3hA:
undetectable
3ce6C-4c3hA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus)
PF03486
(HI0933_like)
4 GLN A 156
THR A   6
THR A 348
HIS A 389
None
1.18A 3ce6C-4cnkA:
undetectable
3ce6C-4cnkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
4 GLN A 358
THR A 373
HIS A 383
LEU A 136
None
1.35A 3ce6C-4jklA:
undetectable
3ce6C-4jklA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  62
THR A  63
THR A 198
HIS A 342
LEU A 383
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 503 ( 3.9A)
0.62A 3ce6C-4lvcA:
59.7
3ce6C-4lvcA:
58.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
salexigens)
PF03480
(DctP)
4 THR A 229
THR A 235
HIS A 237
LEU A 185
None
1.02A 3ce6C-4n6kA:
undetectable
3ce6C-4n6kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Legionella
pneumophila)
PF00701
(DHDPS)
4 GLN A 111
THR A 110
THR A  81
HIS A 120
None
None
MRD  A 301 ( 4.2A)
MRD  A 301 ( 4.8A)
1.25A 3ce6C-4nq1A:
undetectable
3ce6C-4nq1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1


(Homo sapiens;
synthetic
construct)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 GLN A2380
THR A2383
THR A2418
HIS A2097
None
MG  A4404 ( 4.6A)
None
None
1.33A 3ce6C-4rh7A:
undetectable
3ce6C-4rh7A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN


(Rhizobium etli)
PF01547
(SBP_bac_1)
4 GLN A 274
THR A 273
HIS A 197
LEU A 195
None
1.18A 3ce6C-4rk2A:
undetectable
3ce6C-4rk2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00285
(Citrate_synt)
4 GLN A 111
THR A 195
THR A 204
LEU A 389
None
1.37A 3ce6C-4tvmA:
undetectable
3ce6C-4tvmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii)
no annotation 4 GLN A 213
THR A 210
THR A 141
HIS A  78
None
None
None
ZN  A 301 (-3.4A)
1.20A 3ce6C-4ubqA:
2.9
3ce6C-4ubqA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 GLN A 138
THR A 283
HIS A 147
LEU A 146
None
1.20A 3ce6C-4usfA:
undetectable
3ce6C-4usfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 THR A 224
THR A 283
HIS A 147
LEU A 146
None
1.14A 3ce6C-4usfA:
undetectable
3ce6C-4usfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE


(Aspergillus
fumigatus)
PF01266
(DAO)
4 GLN A  93
THR A  88
HIS A  27
LEU A  26
None
1.24A 3ce6C-4wctA:
undetectable
3ce6C-4wctA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wss HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 GLN A  15
THR A  14
HIS A 439
LEU A 436
None
1.14A 3ce6C-4wssA:
undetectable
3ce6C-4wssA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 GLN A 259
THR A 283
HIS A 279
LEU A 276
NAD  A 500 ( 4.9A)
None
None
None
1.30A 3ce6C-4xgiA:
undetectable
3ce6C-4xgiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLN A 523
THR A 539
HIS A 586
LEU A 577
None
4CV  A 801 (-2.8A)
None
None
1.22A 3ce6C-4yffA:
undetectable
3ce6C-4yffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA


(Methanothermobacter
marburgensis)
PF02240
(MCR_gamma)
4 THR C 119
THR C 218
HIS C  21
LEU C 145
None
1.32A 3ce6C-5a8rC:
undetectable
3ce6C-5a8rC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE


(Bacillus
subtilis)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
4 GLN A 368
THR A 119
HIS A  94
LEU A  24
None
1.33A 3ce6C-5d01A:
4.3
3ce6C-5d01A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli)
PF01212
(Beta_elim_lyase)
4 GLN A 140
THR A 138
HIS A 463
LEU A 400
None
None
None
EPE  A1003 (-4.3A)
1.16A 3ce6C-5d8gA:
2.4
3ce6C-5d8gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
4 GLN A 201
THR A 157
HIS A 185
LEU A 221
None
1.31A 3ce6C-5du3A:
undetectable
3ce6C-5du3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLN A 530
THR A 529
HIS A 574
LEU A 567
None
5XJ  A 801 (-3.4A)
None
None
1.36A 3ce6C-5fd2A:
undetectable
3ce6C-5fd2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145


(Bacillus sp.
(in: Bacteria))
PF00082
(Peptidase_S8)
4 GLN A   6
THR A   5
THR A  79
HIS A 256
None
1.37A 3ce6C-5ffnA:
undetectable
3ce6C-5ffnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN C 211
THR C 174
THR C 493
LEU C 508
None
1.31A 3ce6C-5fseC:
3.5
3ce6C-5fseC:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN


(Lysinibacillus
sphaericus)
PF05431
(Toxin_10)
4 GLN A 220
THR A 219
THR A 191
LEU A 266
None
1.37A 3ce6C-5g37A:
undetectable
3ce6C-5g37A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLN A  67
THR A  82
HIS A 131
LEU A 121
None
032  A 401 (-3.7A)
None
None
1.15A 3ce6C-5hesA:
undetectable
3ce6C-5hesA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 THR A 483
THR A 477
HIS A 478
LEU A 471
None
1.36A 3ce6C-5i51A:
undetectable
3ce6C-5i51A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lde IMMUNOGLOBULIN
G-BINDING PROTEIN
G,VIRAL FLICE
PROTEIN


(Human
gammaherpesvirus
8;
Streptococcus
sp. 'group G')
PF01335
(DED)
PF01378
(IgG_binding_B)
4 THR A 152
THR A 187
HIS A 183
LEU A 180
None
1.36A 3ce6C-5ldeA:
undetectable
3ce6C-5ldeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE


(Streptomyces
venezuelae)
PF00982
(Glyco_transf_20)
4 GLN A 151
THR A 165
HIS A  94
LEU A  90
None
1.14A 3ce6C-5lqdA:
3.6
3ce6C-5lqdA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE


(Shewanella
oneidensis)
PF03060
(NMO)
4 GLN A 326
THR A 156
HIS A 185
LEU A 191
None
1.15A 3ce6C-5lsmA:
undetectable
3ce6C-5lsmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis)
PF05721
(PhyH)
4 GLN A 111
THR A 227
HIS A  92
LEU A 122
None
1.27A 3ce6C-5nciA:
undetectable
3ce6C-5nciA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 4 GLN A 467
THR A 468
THR A 520
LEU A 608
None
0.94A 3ce6C-5nd1A:
undetectable
3ce6C-5nd1A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Mycolicibacterium
smegmatis)
PF13561
(adh_short_C2)
4 GLN A 188
THR A 184
THR A 134
LEU A 102
None
NAP  A 301 (-3.0A)
NAP  A 301 (-4.2A)
None
1.33A 3ce6C-5t2uA:
8.5
3ce6C-5t2uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2


(Arabidopsis
thaliana)
PF00201
(UDPGT)
4 GLN A  24
THR A  20
THR A 348
LEU A 331
None
UDP  A 503 ( 4.3A)
None
None
1.34A 3ce6C-5u6sA:
undetectable
3ce6C-5u6sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36


(Bos taurus)
no annotation 4 THR A 577
THR A 553
HIS A 527
LEU A 529
None
1.33A 3ce6C-5vhaA:
3.1
3ce6C-5vhaA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19


(Enterobacteria
phage T4 sensu
lato)
PF06841
(Phage_T4_gp19)
4 GLN A  35
THR A  33
THR A  39
LEU A 157
None
1.25A 3ce6C-5w5fA:
undetectable
3ce6C-5w5fA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 GLN B1065
THR B1090
HIS B1025
LEU B1026
None
1.22A 3ce6C-5xogB:
undetectable
3ce6C-5xogB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila)
no annotation 4 GLN A 272
THR A 282
HIS A 403
LEU A 407
None
None
ADP  A1101 (-4.0A)
ADP  A1101 (-4.8A)
1.30A 3ce6C-5zq6A:
undetectable
3ce6C-5zq6A:
10.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLN A  62
THR A  63
THR A 162
HIS A 306
LEU A 349
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 500 ( 4.3A)
0.22A 3ce6C-6aphA:
56.5
3ce6C-6aphA:
54.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbo APOBEC3H

(Homo sapiens)
no annotation 4 GLN A  33
THR A  43
HIS A 101
LEU A 102
None
1.35A 3ce6C-6bboA:
undetectable
3ce6C-6bboA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3


(Homo sapiens)
no annotation 4 GLN A 466
THR A 378
THR A 203
HIS A 373
None
None
None
ZN  A 902 (-3.3A)
1.09A 3ce6C-6c01A:
undetectable
3ce6C-6c01A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-)
no annotation 4 GLN A 466
THR A 379
THR A 204
HIS A 374
None
None
None
ZN  A1002 (-3.1A)
1.11A 3ce6C-6f2tA:
undetectable
3ce6C-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 5 GLN B  65
THR B  66
THR B 165
HIS B 323
LEU B 373
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
NAD  B 501 ( 3.9A)
0.57A 3ce6C-6f3mB:
52.2
3ce6C-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 5 GLN A  60
THR A  61
THR A 160
HIS A 304
LEU A 347
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
NAD  A 502 (-3.9A)
0.65A 3ce6C-6gbnA:
55.7
3ce6C-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1


(Homo sapiens)
no annotation 4 GLN A 350
THR A  60
THR A  64
LEU A 304
None
1.13A 3ce6C-6gmbA:
undetectable
3ce6C-6gmbA:
12.76