SIMILAR PATTERNS OF AMINO ACIDS FOR 3CCF_A_BEZA261_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 GLY A 425
ASN A 424
PHE A 416
ARG A 412
 LYS  A 505 ( 4.1A)
LYS  A 505 (-4.0A)
None
None
 1.32A 3ccfA-1bbuA:
undetectable		 3ccfA-1bbuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 131
ASN A 149
PHE A 154
ARG A 130
 HEM  A3000 (-3.6A)
None
None
None
 1.30A 3ccfA-1dgfA:
undetectable		 3ccfA-1dgfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 GLY A 161
ASN A 162
PHE A 404
TYR A 169
 None
 1.21A 3ccfA-1h14A:
undetectable		 3ccfA-1h14A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLY A 600
TRP A 312
PHE A 365
TYR A 609
 None
R03  A 800 (-3.9A)
R03  A 800 ( 4.0A)
None
 1.42A 3ccfA-1h39A:
undetectable		 3ccfA-1h39A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 GLY A 191
ASN A 247
TRP A 112
TYR A 246
 None
None
None
2PE  A 503 ( 4.1A)
 1.24A 3ccfA-1icpA:
undetectable		 3ccfA-1icpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 GLY A 411
ASN A 409
TRP A 487
ARG A 547
 None
 1.05A 3ccfA-1j1wA:
undetectable		 3ccfA-1j1wA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 GLY A 691
ASN A 690
PHE A 469
ARG A 665
 None
 1.39A 3ccfA-1jx2A:
undetectable		 3ccfA-1jx2A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3d TYPE IV COLLAGEN
NONCOLLAGENOUS
DOMAIN- ALPHA2

(Bos taurus) 		PF01413
(C4) 		4 GLY C 152
ASN C  43
PHE C 170
TYR C  34
 None
 1.39A 3ccfA-1m3dC:
undetectable		 3ccfA-1m3dC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASN A 546
TRP A 472
PHE A 397
TYR A 543
 None
None
HE3  A1406 (-4.7A)
HE3  A1406 (-4.4A)
 1.28A 3ccfA-1ozhA:
3.2		 3ccfA-1ozhA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 GLY A 139
ASN A 143
PHE A 159
TYR A 142
 None
 1.37A 3ccfA-1qozA:
2.1		 3ccfA-1qozA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 HIS A 132
GLY A 400
PHE A 137
ARG A 401
 None
 1.38A 3ccfA-1r9jA:
3.0		 3ccfA-1r9jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		4 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 HIS  A  22 ( 1.0A)
GLY  A  11 ( 0.0A)
ASN  A  23 ( 0.6A)
TYR  A  17 ( 1.3A)
 1.40A 3ccfA-1rynA:
undetectable		 3ccfA-1rynA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		4 ASN A 195
TRP A 225
TRP A 146
TYR A 196
 None
 1.35A 3ccfA-1s1dA:
undetectable		 3ccfA-1s1dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 110
ASN A 128
PHE A 133
ARG A 109
 HEM  A 501 (-3.3A)
None
None
None
 1.33A 3ccfA-1si8A:
undetectable		 3ccfA-1si8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmf THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP3)

(Cardiovirus B) 		PF00073
(Rhv) 		4 GLY 3  55
ASN 3  56
PHE 3 113
TYR 3  81
 None
 1.42A 3ccfA-1tmf3:
undetectable		 3ccfA-1tmf3:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 HIS A 276
GLY A 277
TRP A 347
PHE A 364
 B2G  A1399 ( 3.8A)
CA  A1398 ( 4.8A)
B2G  A1399 (-3.7A)
None
 1.19A 3ccfA-1ur4A:
undetectable		 3ccfA-1ur4A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLY A 224
ASN A 228
TYR A 229
ARG A 223
 None
 1.40A 3ccfA-1w78A:
undetectable		 3ccfA-1w78A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whh CLIPR-59

(Mus musculus) 		PF01302
(CAP_GLY) 		4 HIS A  67
GLY A  84
TRP A  55
PHE A  50
 None
 1.35A 3ccfA-1whhA:
undetectable		 3ccfA-1whhA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 HIS A 592
GLY A 458
ASN A 459
TYR A 374
 ATP  A 701 (-4.1A)
None
ATP  A 701 ( 4.6A)
ATP  A 701 ( 4.2A)
 1.04A 3ccfA-1xdpA:
1.0		 3ccfA-1xdpA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 GLY A 149
ASN A 182
PHE A 143
TYR A 148
 None
 1.25A 3ccfA-1xr5A:
undetectable		 3ccfA-1xr5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0l 33H1 FV FRAGMENT
33H1 FV FRAGMENT

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLY D  99
ASN D  36
PHE C  92
TYR D  51
 None
 0.85A 3ccfA-2a0lD:
undetectable		 3ccfA-2a0lD:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		4 HIS A 299
GLY A 316
ASN A 317
PHE A 404
 HEM  A1511 (-3.3A)
HEM  A1510 (-4.1A)
HEM  A1511 (-3.2A)
HEM  A1511 ( 3.8A)
 1.34A 3ccfA-2e80A:
undetectable		 3ccfA-2e80A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 HIS A 532
GLY A 454
ASN A 534
ARG A 456
 None
 1.24A 3ccfA-2fafA:
undetectable		 3ccfA-2fafA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 HIS D 142
GLY D 141
ASN D 138
TYR D 153
 None
 1.13A 3ccfA-2g9hD:
undetectable		 3ccfA-2g9hD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 GLY A 371
ASN A 369
TYR A 351
ARG A 370
 None
 1.35A 3ccfA-2i3oA:
undetectable		 3ccfA-2i3oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 HIS A1542
GLY A1543
ASN A1549
PHE A1646
 None
 1.22A 3ccfA-2pffA:
5.0		 3ccfA-2pffA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 482
ASN A 481
PHE A 703
TYR A 479
 None
CL  A 807 (-3.9A)
None
None
 1.35A 3ccfA-2pncA:
undetectable		 3ccfA-2pncA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pns ERVATAMIN-C, A
PAPAIN-LIKE PLANT
CYSTEINE PROTEASE

(Tabernaemontana
divaricata) 		PF00112
(Peptidase_C1) 		4 HIS A  61
GLY A  66
ASN A  60
TYR A  70
 None
THJ  A 601 (-4.5A)
None
None
 1.25A 3ccfA-2pnsA:
undetectable		 3ccfA-2pnsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 HIS A  21
GLY A  20
ASN A 382
PHE A 146
 None
 1.06A 3ccfA-2pq6A:
4.0		 3ccfA-2pq6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4k UNCHARACTERIZED
PROTEIN C11ORF68

(Homo sapiens) 		PF08939
(DUF1917) 		4 GLY A 145
TRP A  53
PHE A  40
ARG A 148
 None
 1.02A 3ccfA-2q4kA:
undetectable		 3ccfA-2q4kA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4) 		4 HIS A  88
GLY A  84
TRP A 158
TYR A 167
 None
None
None
GOL  A 215 (-4.8A)
 1.25A 3ccfA-2qzcA:
undetectable		 3ccfA-2qzcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		4 GLY A 204
ASN A 188
TRP A  55
TYR A 206
 None
 1.37A 3ccfA-2rfzA:
undetectable		 3ccfA-2rfzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 GLY A 334
TRP A 185
PHE A 186
TYR A 225
 None
None
None
COA  A1383 (-4.1A)
 1.32A 3ccfA-2vatA:
2.8		 3ccfA-2vatA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 GLY A 426
ASN A 420
TRP A 262
PHE A 423
 None
 0.87A 3ccfA-2vrkA:
undetectable		 3ccfA-2vrkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 GLY A  76
ASN A 113
PHE A 276
TYR A  72
 None
None
None
CAC  A 403 ( 4.7A)
 0.72A 3ccfA-2vw8A:
undetectable		 3ccfA-2vw8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		4 HIS A  22
GLY A  26
ASN A  27
ARG A  59
 None
 1.26A 3ccfA-2wu8A:
undetectable		 3ccfA-2wu8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 HIS A  64
GLY A 120
ASN A 137
PHE A 150
 3TR  A 695 ( 2.7A)
HDD  A 690 (-3.5A)
3TR  A 695 ( 2.6A)
HDD  A 690 ( 3.5A)
 1.35A 3ccfA-2xf2A:
4.1		 3ccfA-2xf2A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 121
ASN A 139
PHE A 144
ARG A 120
 None
 1.24A 3ccfA-2xq1A:
undetectable		 3ccfA-2xq1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 GLY A  51
ASN A  40
PHE A 101
TYR A  52
 None
 1.40A 3ccfA-2xsgA:
undetectable		 3ccfA-2xsgA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 HIS A 421
GLY A 400
ASN A 362
PHE A 418
 None
 1.36A 3ccfA-2zuxA:
undetectable		 3ccfA-2zuxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 HIS A 388
GLY A 367
ASN A 329
PHE A 385
 None
 1.42A 3ccfA-2zuyA:
undetectable		 3ccfA-2zuyA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 GLY B 228
PHE B 154
TYR B 271
ARG B 232
 None
 1.38A 3ccfA-3aqcB:
undetectable		 3ccfA-3aqcB:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		8 HIS A 109
GLY A 136
ASN A 140
TRP A 166
TRP A 207
PHE A 211
TYR A 249
ARG A 251
 BEZ  A 261 (-3.7A)
BEZ  A 261 ( 3.7A)
BEZ  A 261 (-3.1A)
BEZ  A 261 (-3.7A)
BEZ  A 261 ( 4.6A)
BEZ  A 261 (-3.6A)
BEZ  A 261 (-4.2A)
BEZ  A 261 (-3.9A)
 0.00A 3ccfA-3ccfA:
41.2		 3ccfA-3ccfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 HIS A 109
GLY A 136
TRP A 110
PHE A 211
TYR A 249
ARG A 251
 BEZ  A 261 (-3.7A)
BEZ  A 261 ( 3.7A)
None
BEZ  A 261 (-3.6A)
BEZ  A 261 (-4.2A)
BEZ  A 261 (-3.9A)
 1.47A 3ccfA-3ccfA:
41.2		 3ccfA-3ccfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 HIS A 369
ASN A 406
TRP A 409
TRP A 302
 FAD  A 521 (-4.4A)
FAD  A 521 (-3.3A)
None
None
 0.99A 3ccfA-3cvwA:
2.8		 3ccfA-3cvwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 HIS A 109
GLY A 115
ASN A 116
PHE A 136
 None
 1.25A 3ccfA-3h09A:
undetectable		 3ccfA-3h09A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		4 GLY A 124
ASN A 172
PHE A  14
TYR A 125
 GOL  A 502 ( 4.0A)
None
None
None
 1.36A 3ccfA-3h14A:
3.2		 3ccfA-3h14A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1y PHOSPHOSERINE
PHOSPHATASE (SERB)

(Helicobacter
pylori) 		PF00702
(Hydrolase) 		4 HIS A 134
GLY A 133
ASN A 118
PHE A  95
 None
 1.27A 3ccfA-3m1yA:
3.0		 3ccfA-3m1yA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus) 		PF00915
(Calici_coat) 		4 HIS A 563
GLY A 632
ASN A 562
ARG A 656
 None
 1.25A 3ccfA-3m8lA:
undetectable		 3ccfA-3m8lA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		4 HIS A 171
GLY A 216
ASN A 223
PHE A 176
 M3R  A 430 (-3.9A)
None
None
None
 1.25A 3ccfA-3mtwA:
undetectable		 3ccfA-3mtwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		4 HIS A 171
GLY A 216
ASN A 223
PHE A 219
 M3R  A 430 (-3.9A)
None
None
M3R  A 430 (-4.3A)
 1.12A 3ccfA-3mtwA:
undetectable		 3ccfA-3mtwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		4 HIS A  50
GLY A  53
ASN A  56
ARG A  52
 None
 1.40A 3ccfA-3n4tA:
undetectable		 3ccfA-3n4tA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		4 GLY A 149
ASN A 182
PHE A 143
TYR A 148
 None
 1.32A 3ccfA-3n6nA:
undetectable		 3ccfA-3n6nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o26 SALUTARIDINE
REDUCTASE

(Papaver
somniferum) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 GLY A 100
ASN A 152
PHE A 104
TYR A 236
 NDP  A 312 (-3.6A)
None
None
NDP  A 312 (-4.7A)
 1.32A 3ccfA-3o26A:
6.8		 3ccfA-3o26A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		4 GLY A2163
TRP A2229
PHE A2114
TYR A2240
 None
 1.37A 3ccfA-3opeA:
undetectable		 3ccfA-3opeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxh RV0577 PROTEIN

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 HIS A 132
GLY A 134
ASN A  13
TYR A  80
 PMB  A 301 ( 4.0A)
None
None
None
 1.14A 3ccfA-3oxhA:
undetectable		 3ccfA-3oxhA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcx SPHINGOMYELINASE C

(Streptomyces
griseocarneus) 		PF03372
(Exo_endo_phos) 		4 HIS A 331
GLY A 330
TYR A 279
ARG A 278
 SIN  A 402 (-3.8A)
None
SIN  A 402 (-4.8A)
SIN  A 402 (-3.5A)
 1.06A 3ccfA-3wcxA:
2.1		 3ccfA-3wcxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 HIS A 360
GLY A 606
ASN A 604
PHE A 370
 None
 1.29A 3ccfA-3wstA:
8.5		 3ccfA-3wstA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  85
GLY A 100
ASN A 104
TRP A 471
 CU  A 614 (-3.1A)
None
None
None
 1.16A 3ccfA-3x1bA:
undetectable		 3ccfA-3x1bA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 HIS A 186
GLY A  75
ASN A  79
TYR A 143
 NAP  A 900 ( 3.4A)
GDP  A 901 (-3.1A)
None
None
 1.39A 3ccfA-4b8wA:
3.0		 3ccfA-4b8wA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		4 HIS A   9
ASN A 127
TRP A 133
PHE A 123
 None
 1.19A 3ccfA-4b96A:
undetectable		 3ccfA-4b96A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fno PEPTIDYL-TRNA
HYDROLASE

(Pseudomonas
aeruginosa) 		PF01195
(Pept_tRNA_hydro) 		4 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 None
None
GOL  A 203 ( 4.6A)
None
 1.34A 3ccfA-4fnoA:
undetectable		 3ccfA-4fnoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 GLY A 425
TRP A 398
PHE A 407
ARG A 426
 None
 1.34A 3ccfA-4g5eA:
undetectable		 3ccfA-4g5eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 HIS A  16
GLY A  19
PHE A 394
TYR A  94
 None
 1.42A 3ccfA-4ggpA:
4.5		 3ccfA-4ggpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 4 GLY A 136
ASN A 135
PHE A  86
TYR A 133
 None
 1.32A 3ccfA-4gqzA:
undetectable		 3ccfA-4gqzA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		4 HIS B  69
GLY B 120
ASN B 117
TYR B 119
 None
 1.34A 3ccfA-4mbgB:
undetectable		 3ccfA-4mbgB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		4 HIS A 426
GLY A 427
TRP A 305
ARG A 428
 None
 1.29A 3ccfA-4mq0A:
undetectable		 3ccfA-4mq0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 HIS A 178
GLY A 134
TYR A 133
ARG A 135
 None
None
25L  A1000 (-4.7A)
None
 1.16A 3ccfA-4o1oA:
undetectable		 3ccfA-4o1oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		4 HIS A 577
GLY A 576
TRP A 516
PHE A 537
 None
 1.28A 3ccfA-4pljA:
undetectable		 3ccfA-4pljA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 HIS A 125
GLY A 579
PHE A 106
ARG A 581
 None
 1.36A 3ccfA-4pxqA:
undetectable		 3ccfA-4pxqA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 HIS H  43
GLY H  13
TYR H 391
ARG H  12
 None
 1.36A 3ccfA-4qslH:
4.1		 3ccfA-4qslH:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 GLY A 215
ASN A 220
TRP A 234
PHE A 233
 None
 1.20A 3ccfA-4r6yA:
undetectable		 3ccfA-4r6yA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 HIS A2773
GLY A2739
ASN A2740
TYR A2738
 None
 1.29A 3ccfA-4rlvA:
undetectable		 3ccfA-4rlvA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 GLY A1129
ASN A1125
TRP A1143
ARG A1128
 None
 1.31A 3ccfA-4uwaA:
undetectable		 3ccfA-4uwaA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 HIS A 248
GLY A 205
ASN A 206
PHE A 314
 None
 1.40A 3ccfA-4xwhA:
undetectable		 3ccfA-4xwhA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 GLY A 106
ASN A 105
TRP C 372
PHE C 327
 None
 0.92A 3ccfA-5aa5A:
undetectable		 3ccfA-5aa5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 395
ASN A 396
PHE A 482
TYR A 264
 TPP  A 700 (-3.4A)
TPP  A 700 (-4.0A)
None
FAD  A 701 (-4.8A)
 1.43A 3ccfA-5ahkA:
undetectable		 3ccfA-5ahkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bop NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 GLY A 104
ASN A 111
PHE A  47
TYR A 112
 None
 1.30A 3ccfA-5bopA:
undetectable		 3ccfA-5bopA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 HIS A 316
GLY A 318
ASN A 259
TRP A 465
 None
None
GAL  A 701 (-4.0A)
LOG  A 702 (-3.8A)
 1.23A 3ccfA-5bxpA:
undetectable		 3ccfA-5bxpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NSP1
NUCLEOPORIN NIC96

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF05064
(Nsp1_C)
no annotation 		4 HIS C 626
GLY C 625
ASN F 150
PHE F 143
 None
 1.32A 3ccfA-5cwsC:
undetectable		 3ccfA-5cwsC:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 GLY B 426
ASN B 421
TRP B 499
TYR B 422
 None
 0.99A 3ccfA-5iklB:
undetectable		 3ccfA-5iklB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		4 GLY A 395
ASN A 394
TRP A 322
TYR A 387
 None
 1.14A 3ccfA-5j39A:
undetectable		 3ccfA-5j39A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 460
TRP A 458
TYR A 497
ARG A 448
 None
 1.37A 3ccfA-5jp0A:
undetectable		 3ccfA-5jp0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwy PHOSPHATIDYLGLYCEROP
HOSPHATASE B

(Escherichia
coli) 		PF01569
(PAP2) 		4 TRP A  29
TRP A 151
PHE A 106
ARG A 201
 None
 1.33A 3ccfA-5jwyA:
undetectable		 3ccfA-5jwyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 GLY A  85
TRP A  88
TYR A 245
ARG A 112
 None
None
ICS  A 502 (-4.1A)
ICS  A 502 (-4.1A)
 1.40A 3ccfA-5kojA:
undetectable		 3ccfA-5kojA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkw PUTATIVE OMPA FAMILY
LIPOPROTEIN

(Burkholderia
cenocepacia) 		PF00691
(OmpA) 		4 GLY A 108
ASN A 113
PHE A  70
TYR A 112
 API  A 201 ( 4.5A)
API  A 201 (-3.3A)
API  A 201 (-4.5A)
None
 1.29A 3ccfA-5lkwA:
undetectable		 3ccfA-5lkwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 HIS A 270
GLY A 271
ASN A 371
PHE A  61
 None
 1.26A 3ccfA-5svcA:
undetectable		 3ccfA-5svcA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6t HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLY A  72
ASN A 150
PHE A 118
ARG A 149
 None
 1.32A 3ccfA-5w6tA:
undetectable		 3ccfA-5w6tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE

(Sinorhizobium
meliloti) 		no annotation 4 HIS A 270
GLY A 381
ASN A 380
TYR A 384
 None
 1.20A 3ccfA-5wa0A:
undetectable		 3ccfA-5wa0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Enterococcus
faecalis) 		PF01867
(Cas_Cas1) 		4 GLY A 175
ASN A 177
PHE A 156
TYR A 180
 None
 1.26A 3ccfA-5xvnA:
undetectable		 3ccfA-5xvnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-) 		no annotation 4 GLY B 187
ASN B 188
PHE B  22
ARG B 191
 None
 1.26A 3ccfA-5y35B:
undetectable		 3ccfA-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 HIS A 630
GLY A 629
ASN A 584
TRP A 427
 None
 1.04A 3ccfA-5z0uA:
undetectable		 3ccfA-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 HIS A 496
GLY A 497
ASN A 438
TRP A 495
 None
 1.18A 3ccfA-5ze3A:
undetectable		 3ccfA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio) 		no annotation 4 HIS A  23
GLY A  27
ASN A  26
ARG A  30
 None
 1.41A 3ccfA-5zu6A:
undetectable		 3ccfA-5zu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 4 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 None
 1.27A 3ccfA-6a31A:
undetectable		 3ccfA-6a31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b57 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		no annotation 4 GLY A 395
ASN A 394
TRP A 322
TYR A 387
 None
 1.12A 3ccfA-6b57A:
undetectable		 3ccfA-6b57A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 4 HIS A  97
GLY A  28
ASN A  29
PHE A 133
 MN  A 301 ( 3.3A)
13P  A 302 (-3.4A)
13P  A 302 (-3.8A)
13P  A 302 ( 4.9A)
 1.21A 3ccfA-6btgA:
undetectable		 3ccfA-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 GLY A 391
ASN A 392
TRP A 389
PHE A 323
 None
 1.12A 3ccfA-6bv2A:
undetectable		 3ccfA-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus) 		no annotation 4 HIS F  32
GLY F  31
ASN F 122
PHE F 105
 None
 1.37A 3ccfA-6cfwF:
undetectable		 3ccfA-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 HIS A 885
GLY A 892
TRP A 879
PHE A 900
 None
 1.40A 3ccfA-6etzA:
undetectable		 3ccfA-6etzA:
undetectable