SIMILAR PATTERNS OF AMINO ACIDS FOR 3C7Q_A_XINA1172_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
VAL A  64
PHE A  82
CYH A  83
LEU A 133
 None
 0.56A 3c7qA-1h4lA:
18.1		 3c7qA-1h4lA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
GLU A 277
ALA A 288
LYS A 290
VAL A 318
PHE A 336
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.60A 3c7qA-1opkA:
29.6		 3c7qA-1opkA:
26.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
GLY A 617
ALA A 642
LYS A 644
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 None
 0.60A 3c7qA-1rjbA:
35.2		 3c7qA-1rjbA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
GLY A  79
ALA A  99
LYS A 101
GLY A 153
LEU A 201
CYH A 211
 ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
ATP  A 535 ( 4.5A)
 0.83A 3c7qA-1s9iA:
21.1		 3c7qA-1s9iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
GLY A  79
ALA A  99
VAL A 131
GLY A 153
LEU A 201
CYH A 211
 ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-3.6A)
5EA  A1001 (-4.5A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
ATP  A 535 ( 4.5A)
 0.67A 3c7qA-1s9iA:
21.1		 3c7qA-1s9iA:
23.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
GLY A 596
GLU A 605
ALA A 621
LYS A 623
VAL A 654
CYH A 673
GLY A 676
LEU A 799
CYH A 809
 STI  A   3 ( 3.8A)
None
None
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
 0.79A 3c7qA-1t46A:
30.7		 3c7qA-1t46A:
53.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
GLY A 345
ALA A 367
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.48A 3c7qA-1u59A:
30.1		 3c7qA-1u59A:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
ALA A  36
LYS A  38
VAL A  68
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.61A 3c7qA-1zltA:
20.3		 3c7qA-1zltA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
ALA A  47
LYS A  49
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.71A 3c7qA-2bujA:
22.1		 3c7qA-2bujA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
ALA X  37
LYS X  39
VAL X  67
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.67A 3c7qA-2dq7X:
29.6		 3c7qA-2dq7X:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
GLU A 172
ALA A 184
LYS A 186
VAL A 220
GLY A 240
LEU A 290
 None
 1.05A 3c7qA-2eu9A:
21.4		 3c7qA-2eu9A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
GLY A 163
GLU A 172
ALA A 184
LYS A 186
VAL A 220
LEU A 290
 None
 0.71A 3c7qA-2eu9A:
21.4		 3c7qA-2eu9A:
24.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
ALA A 293
LYS A 295
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.94A 3c7qA-2hckA:
27.5		 3c7qA-2hckA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 3c7qA-2hckA:
27.5		 3c7qA-2hckA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
GLY A 252
ALA A 271
LYS A 273
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.83A 3c7qA-2hk5A:
23.9		 3c7qA-2hk5A:
39.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
GLY A  56
ALA A  76
GLY A 130
LEU A 177
CYH A 190
 None
 0.57A 3c7qA-2hw6A:
19.4		 3c7qA-2hw6A:
26.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
GLY A 249
GLU A 258
ALA A 269
LYS A 271
VAL A 299
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
None
None
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.62A 3c7qA-2hz0A:
29.8		 3c7qA-2hz0A:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 GLY A 429
ALA A 452
LYS A 454
VAL A 484
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 (-3.1A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.80A 3c7qA-2j0jA:
32.6		 3c7qA-2j0jA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 429
ALA A 452
LYS A 454
VAL A 484
CYH A 502
GLY A 505
LEU A 553
 BII  A1687 ( 3.8A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.55A 3c7qA-2jkmA:
24.1		 3c7qA-2jkmA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
GLY A 589
GLU A 598
ALA A 614
LYS A 616
VAL A 647
CYH A 666
GLY A 669
LEU A 785
 None
 0.56A 3c7qA-2ogvA:
34.8		 3c7qA-2ogvA:
51.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
ALA A 367
LYS A 369
VAL A 399
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
 0.84A 3c7qA-2ozoA:
23.9		 3c7qA-2ozoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
ALA A 367
LYS A 369
VAL A 399
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.92A 3c7qA-2ozoA:
23.9		 3c7qA-2ozoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  68
GLY A  69
ALA A  92
LYS A  94
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.65A 3c7qA-2z7rA:
21.2		 3c7qA-2z7rA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1002
GLY A1003
GLU A1012
ALA A1028
LYS A1030
VAL A1060
 S91  A   1 ( 4.1A)
S91  A   1 ( 3.9A)
None
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
 0.61A 3c7qA-2z8cA:
21.6		 3c7qA-2z8cA:
36.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
ALA A 273
LYS A 275
VAL A 303
PHE A 321
GLY A 325
LEU A 374
 None
 0.86A 3c7qA-2zv7A:
25.7		 3c7qA-2zv7A:
37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
GLY A 254
ALA A 273
LYS A 275
PHE A 321
GLY A 325
LEU A 374
 None
 0.83A 3c7qA-2zv7A:
25.7		 3c7qA-2zv7A:
37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.63A 3c7qA-3b2tA:
27.5		 3c7qA-3b2tA:
53.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 431
GLY A 432
GLU A 441
ALA A 455
LYS A 457
VAL A 487
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
None
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-4.5A)
 0.65A 3c7qA-3fzpA:
30.9		 3c7qA-3fzpA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 833
GLY A 834
ALA A 859
LYS A 861
VAL A 892
VAL A 909
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
None
 0.47A 3c7qA-3hngA:
36.8		 3c7qA-3hngA:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 833
GLY A 834
ALA A 859
VAL A 892
VAL A 909
CYH A 912
GLY A 915
LEU A1029
CYH A1039
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
 0.60A 3c7qA-3hngA:
36.8		 3c7qA-3hngA:
67.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  46
LYS A  48
VAL A  79
PHE A 105
CYH A 106
LEU A 156
 None
 0.59A 3c7qA-3mi9A:
10.0		 3c7qA-3mi9A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
GLY A  89
ALA A 109
LYS A 111
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
 0.59A 3c7qA-3nuuA:
22.7		 3c7qA-3nuuA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
ALA A 213
LYS A 215
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.73A 3c7qA-3nyoA:
20.7		 3c7qA-3nyoA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
ALA A 576
LYS A 578
VAL A 609
GLY A 631
LEU A 683
CYH A 693
 STU  A   1 (-3.2A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.82A 3c7qA-3ppzA:
26.9		 3c7qA-3ppzA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
GLY A  64
ALA A  84
LYS A  86
VAL A 210
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 1.12A 3c7qA-3q5iA:
19.4		 3c7qA-3q5iA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  50
GLY A  51
GLU A  60
ALA A  71
LYS A  73
VAL A  98
GLY A 124
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
None
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 (-3.0A)
None
 0.84A 3c7qA-3sheA:
18.2		 3c7qA-3sheA:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
ALA A 512
LYS A 514
VAL A 561
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.66A 3c7qA-3tt0A:
35.1		 3c7qA-3tt0A:
48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
GLY A 362
ALA A 382
PHE A 435
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.45A 3c7qA-3txoA:
13.6		 3c7qA-3txoA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
GLU A 850
ALA A 866
LYS A 868
VAL A 916
PHE A 918
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
 0.71A 3c7qA-3vidA:
43.6		 3c7qA-3vidA:
85.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 840
GLY A 841
GLU A 850
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.46A 3c7qA-3vidA:
43.6		 3c7qA-3vidA:
85.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
ALA A  96
LYS A  98
VAL A 128
GLY A 149
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 (-4.8A)
 0.90A 3c7qA-3wigA:
21.6		 3c7qA-3wigA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  75
GLY A  76
ALA A  96
LYS A  98
VAL A 128
GLY A 150
LEU A 198
CYH A 208
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 ( 3.7A)
 1.10A 3c7qA-3wigA:
21.6		 3c7qA-3wigA:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 840
GLU A 850
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
None
LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.47A 3c7qA-3wzdA:
39.0		 3c7qA-3wzdA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 840
GLY A 841
GLU A 850
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
None
LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.81A 3c7qA-3wzdA:
39.0		 3c7qA-3wzdA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
ALA A  31
LYS A  33
VAL A  63
PHE A  81
LEU A 132
CYH A 142
 38R  A 350 ( 3.9A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.69A 3c7qA-3zduA:
21.5		 3c7qA-3zduA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
GLY A  60
ALA A  80
LYS A  82
VAL A 114
CYH A 133
 939  A1331 (-3.7A)
939  A1331 ( 4.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
 0.53A 3c7qA-4a4lA:
21.8		 3c7qA-4a4lA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU A 840
GLY A 841
GLU A 850
ALA A 866
LYS A 868
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
 0.62A 3c7qA-4agdA:
39.4		 3c7qA-4agdA:
89.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
ALA A  31
LYS A  33
VAL A  64
CYH A  83
LEU A 133
CYH A 143
 D15  A 500 (-3.8A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.3A)
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
 0.53A 3c7qA-4aguA:
22.3		 3c7qA-4aguA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
ALA A 121
LYS A 123
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.58A 3c7qA-4aw5A:
27.5		 3c7qA-4aw5A:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
GLY A  69
ALA A  89
LYS A  91
VAL A 123
CYH A 142
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.6A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.4A)
9ZP  A1333 (-4.1A)
 0.58A 3c7qA-4b6lA:
22.2		 3c7qA-4b6lA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
GLY A  43
ALA A  63
VAL A  94
PHE A 112
CYH A 113
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.9A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.60A 3c7qA-4bc6A:
20.4		 3c7qA-4bc6A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
GLY A 247
ALA A 267
LYS A 269
GLY A 324
LEU A 371
 None
 0.51A 3c7qA-4c0tA:
21.8		 3c7qA-4c0tA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
ALA A 684
LYS A 686
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.60A 3c7qA-4crsA:
19.9		 3c7qA-4crsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
ALA A  36
LYS A  38
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.69A 3c7qA-4eutA:
18.9		 3c7qA-4eutA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
ALA A  36
LYS A  38
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.72A 3c7qA-4euuA:
17.2		 3c7qA-4euuA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.41A 3c7qA-4euuA:
17.2		 3c7qA-4euuA:
25.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.84A 3c7qA-4f4pA:
29.0		 3c7qA-4f4pA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
GLY A 515
GLU A 524
ALA A 538
LYS A 540
PHE A 595
GLY A 599
 0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
None
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
 0.70A 3c7qA-4feqA:
24.7		 3c7qA-4feqA:
37.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 GLY A 328
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.4A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.61A 3c7qA-4fieA:
20.8		 3c7qA-4fieA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.83A 3c7qA-4fl3A:
29.0		 3c7qA-4fl3A:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
GLU A1132
ALA A1148
LYS A1150
VAL A1180
GLY A1201
LEU A1256
 0UV  A1501 (-3.8A)
None
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.4A)
0UV  A1501 (-4.6A)
 1.08A 3c7qA-4fodA:
29.5		 3c7qA-4fodA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
GLY A1123
GLU A1132
ALA A1148
LYS A1150
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.3A)
None
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 1.00A 3c7qA-4fodA:
29.5		 3c7qA-4fodA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  30
ALA A  50
VAL A  84
VAL A 100
GLY A 106
LEU A 153
 STU  A 401 (-3.3A)
STU  A 401 (-3.2A)
None
None
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.36A 3c7qA-4fr4A:
20.3		 3c7qA-4fr4A:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
GLY A 829
ALA A 853
LYS A 855
VAL A 884
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.74A 3c7qA-4hviA:
23.8		 3c7qA-4hviA:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
GLY A 133
ALA A 156
LYS A 158
GLY A 211
LEU A 259
 None
 0.47A 3c7qA-4hzsA:
27.2		 3c7qA-4hzsA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
ALA A 427
LYS A 429
VAL A 453
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.80A 3c7qA-4idtA:
21.1		 3c7qA-4idtA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 LEU A  45
GLY A  46
GLU A  55
ALA A  66
LYS A  68
VAL A 100
CYH A 119
 None
 0.77A 3c7qA-4j7bA:
22.0		 3c7qA-4j7bA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
 0.67A 3c7qA-4jlcA:
18.1		 3c7qA-4jlcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.87A 3c7qA-4k11A:
27.7		 3c7qA-4k11A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 414
ALA A 434
LYS A 436
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 ( 4.3A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.73A 3c7qA-4ks8A:
22.2		 3c7qA-4ks8A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  33
GLY A  34
ALA A  54
LYS A  56
VAL A  83
CYH A 102
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
None
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.64A 3c7qA-4lg4A:
19.0		 3c7qA-4lg4A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  46
GLU A  56
ALA A  67
LYS A  69
VAL A  99
CYH A 126
GLY A 128
LEU A 180
CYH A 190
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.72A 3c7qA-4o38A:
19.9		 3c7qA-4o38A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
GLY A 628
ALA A 648
VAL A 685
GLY A 707
LEU A 753
 None
 0.59A 3c7qA-4otdA:
20.9		 3c7qA-4otdA:
27.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
ALA A 642
LYS A 644
VAL A 675
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.47A 3c7qA-4rt7A:
30.3		 3c7qA-4rt7A:
45.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
ALA A 642
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.55A 3c7qA-4rt7A:
30.3		 3c7qA-4rt7A:
45.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
GLY A  15
GLU A  24
ALA A  35
LYS A  37
VAL A  65
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
None
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.89A 3c7qA-4ueuA:
30.0		 3c7qA-4ueuA:
39.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  40
GLY A  41
ALA A  61
PHE A 110
CYH A 111
GLY A 114
LEU A 162
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 1.15A 3c7qA-4usfA:
18.0		 3c7qA-4usfA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
GLY A 105
ALA A 125
LYS A 127
VAL A 159
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.94A 3c7qA-4wb7A:
20.2		 3c7qA-4wb7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.55A 3c7qA-4wboA:
22.1		 3c7qA-4wboA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
ALA A  72
VAL A 104
PHE A 128
CYH A 129
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.56A 3c7qA-4wsqA:
21.8		 3c7qA-4wsqA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 GLY A 328
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ATP  A 601 ( 4.1A)
ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
ATP  A 601 (-4.6A)
None
None
 0.54A 3c7qA-4xbrA:
17.5		 3c7qA-4xbrA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 473
GLY A 474
ALA A 501
LYS A 503
VAL A 550
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.59A 3c7qA-4xcuA:
34.8		 3c7qA-4xcuA:
52.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
GLU B 277
ALA B 288
LYS B 290
VAL B 318
PHE B 336
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.83A 3c7qA-4xeyB:
30.8		 3c7qA-4xeyB:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
ALA A 642
LYS A 644
VAL A 675
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.81A 3c7qA-4xufA:
34.1		 3c7qA-4xufA:
52.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
ALA A 642
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-4.0A)
None
P30  A1001 (-3.5A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
 0.77A 3c7qA-4xufA:
34.1		 3c7qA-4xufA:
52.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
GLY A 409
ALA A 428
LYS A 430
VAL A 458
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.79A 3c7qA-4y93A:
29.0		 3c7qA-4y93A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.67A 3c7qA-4yhjA:
16.4		 3c7qA-4yhjA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
ALA A 512
LYS A 514
VAL A 561
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.33A 3c7qA-5a46A:
35.2		 3c7qA-5a46A:
46.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
ALA A  44
LYS A  46
VAL A  76
CYH A  95
GLY A  98
LEU A 145
 51W  A 401 (-3.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.64A 3c7qA-5ci7A:
22.8		 3c7qA-5ci7A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  82
ALA A 102
LYS A 104
VAL A 134
GLY A 156
LEU A 211
 ANP  A 401 ( 3.9A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
None
 0.55A 3c7qA-5dbxA:
20.4		 3c7qA-5dbxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
ALA A 275
LYS A 277
PHE A 327
GLY A 331
LEU A 386
CYH A 396
 STU  A 601 (-2.9A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
STU  A 601 (-3.2A)
 0.77A 3c7qA-5e8yA:
23.5		 3c7qA-5e8yA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.40A 3c7qA-5eykA:
14.4		 3c7qA-5eykA:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
GLY A 731
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.74A 3c7qA-5fm2A:
32.2		 3c7qA-5fm2A:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 599
GLY A 600
GLU A 609
ALA A 625
LYS A 627
VAL A 658
CYH A 677
GLY A 680
LEU A 825
CYH A 835
 748  A1001 (-3.8A)
None
None
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
 0.68A 3c7qA-5grnA:
28.2		 3c7qA-5grnA:
49.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
ALA A  77
VAL A 109
CYH A 133
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.79A 3c7qA-5i3oA:
21.5		 3c7qA-5i3oA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
ALA A  43
LYS A  45
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.81A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  95
LEU A 143
 None
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.7A)
6G2  A 901 (-4.7A)
 1.04A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.57A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
GLY A 719
ALA A 743
LYS A 745
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.61A 3c7qA-5j9zA:
30.3		 3c7qA-5j9zA:
33.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 397
GLU A 406
ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.55A 3c7qA-5jznA:
21.6		 3c7qA-5jznA:
27.27