SIMILAR PATTERNS OF AMINO ACIDS FOR 3C6M_C_SPMC501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3j MHC CLASS I HOMOLOG
MIC-A

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 VAL A 142
ASN A 141
TYR A 112
ASP A  82
GLN A  83
 None
 1.33A 3c6mC-1b3jA:
undetectable		 3c6mC-1b3jA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A  76
ASP A 101
ASP A 170
TYR A 239
TRP A 244
 None
 0.70A 3c6mC-1inlA:
23.4		 3c6mC-1inlA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 VAL A  52
TYR A  62
ASP A  87
GLN A 189
TYR A 224
TRP A 229
 None
 0.89A 3c6mC-1iy9A:
23.3		 3c6mC-1iy9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 VAL A  52
TYR A  62
ASP A 156
TYR A 224
TRP A 229
 None
 1.09A 3c6mC-1iy9A:
23.3		 3c6mC-1iy9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		7 VAL A  50
TYR A  60
ASP A  85
ASP A 158
GLN A 191
TYR A 226
TRP A 230
 None
 0.55A 3c6mC-1mjfA:
25.9		 3c6mC-1mjfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A 106
ASP A 131
ASP A 201
GLN A 234
TYR A 270
 None
 0.85A 3c6mC-1xj5A:
24.9		 3c6mC-1xj5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 ASP A 223
VAL A 226
ASN A 227
ASP A 231
GLU A 255
 None
 1.35A 3c6mC-2hxgA:
undetectable		 3c6mC-2hxgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mC-2zsuA:
25.9		 3c6mC-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		7 VAL A  52
TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.3A)
AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.59A 3c6mC-2zsuA:
25.9		 3c6mC-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 VAL A  53
TYR A  63
ASP A  88
ASP A 158
GLN A 191
 None
 1.22A 3c6mC-3o4fA:
20.8		 3c6mC-3o4fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 VAL A  53
TYR A  63
ASP A  88
ASP A 158
TYR A 226
 None
 1.18A 3c6mC-3o4fA:
20.8		 3c6mC-3o4fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A  73
ASP A  98
ASP A 168
GLN A 201
TYR A 237
 S4M  A 301 (-4.4A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
 0.70A 3c6mC-4yv2A:
23.0		 3c6mC-4yv2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		5 VAL A 221
ASN A 205
TYR A 139
ASP A 123
GLU A 191
 None
None
None
ACT  A 402 (-2.9A)
None
 1.31A 3c6mC-5hx0A:
undetectable		 3c6mC-5hx0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 TYR A  84
ASP A 178
GLN A 214
TYR A 251
TRP A 255
 TER  A 402 (-4.6A)
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
TER  A 402 (-3.4A)
TER  A 402 (-3.9A)
 0.59A 3c6mC-6bq6A:
22.9		 3c6mC-6bq6A:
11.87