SIMILAR PATTERNS OF AMINO ACIDS FOR 3C6G_B_VD3B700

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 MET A  60
ALA A  99
VAL A 294
GLY A 304
THR A 104
 None
 1.09A 3c6gB-1al8A:
0.0		 3c6gB-1al8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
 None
 0.81A 3c6gB-1cg4A:
undetectable		 3c6gB-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		5 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
 None
 1.02A 3c6gB-1ci9A:
0.0		 3c6gB-1ci9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		5 LEU B  76
ALA B 139
ALA B 145
VAL B 148
GLY B 130
 None
 0.93A 3c6gB-1d2zB:
undetectable		 3c6gB-1d2zB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A  63
ALA A  31
ALA A  99
VAL A 170
GLY A  68
 None
 1.14A 3c6gB-1ecgA:
undetectable		 3c6gB-1ecgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 PHE A 805
ALA A 549
ALA A 734
VAL A 778
VAL A 826
 None
FMN  A1030 (-3.3A)
None
None
None
 1.14A 3c6gB-1h7wA:
0.0		 3c6gB-1h7wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		5 MET A  92
ALA A 117
ALA A 203
GLY A  88
THR A 210
 None
 1.05A 3c6gB-1o8bA:
0.0		 3c6gB-1o8bA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 MET A 414
ASN A 417
ALA A  66
GLY A  99
GLU A  98
 None
 1.11A 3c6gB-1ozhA:
0.0		 3c6gB-1ozhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE

(Gallus gallus) 		PF00121
(TIM) 		5 ALA A 181
VAL A 184
GLY A 128
GLU A 165
THR A 172
 None
 1.11A 3c6gB-1sq7A:
0.0		 3c6gB-1sq7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 272
ALA A 300
ALA A   8
VAL A   9
THR A 289
 None
 1.15A 3c6gB-1t5cA:
0.0		 3c6gB-1t5cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		5 LEU A 140
PHE A   5
ALA A  23
ALA A  17
GLY A 176
 None
 1.13A 3c6gB-1t8hA:
undetectable		 3c6gB-1t8hA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 387
PHE B 218
ALA B 306
GLY B 298
VAL B 291
 None
 0.91A 3c6gB-1tqyB:
undetectable		 3c6gB-1tqyB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbz 3-KETO-L-GULONATE
6-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		5 PHE A  77
ALA A  63
ALA A  98
VAL A 101
GLY A 107
 None
 1.01A 3c6gB-1xbzA:
undetectable		 3c6gB-1xbzA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 LEU A 389
ASN A 482
ALA A 382
THR A  93
VAL A  52
 None
 1.11A 3c6gB-1xjeA:
undetectable		 3c6gB-1xjeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A 153
ALA A 241
ALA A 143
GLU A 111
THR A 234
 None
 1.11A 3c6gB-1xtzA:
undetectable		 3c6gB-1xtzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxl YCGJ PROTEIN

(Bacillus
subtilis) 		PF08241
(Methyltransf_11) 		5 ALA A  21
ALA A  54
VAL A  59
GLU A  36
THR A  83
 None
 1.11A 3c6gB-1xxlA:
undetectable		 3c6gB-1xxlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 MET A 341
PHE A 368
ALA A 308
ALA A 364
GLY A 156
 None
 0.97A 3c6gB-1ysjA:
undetectable		 3c6gB-1ysjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 LEU A 318
ALA A 122
ALA A  95
VAL A 338
GLY A 315
 AE4  A1346 ( 4.7A)
None
None
None
SO4  A1341 (-3.3A)
 1.03A 3c6gB-2c2nA:
undetectable		 3c6gB-2c2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		6 LEU A 318
ALA A 123
ALA A  95
GLY A 315
GLU A 311
VAL A 288
 AE4  A1346 ( 4.7A)
None
None
SO4  A1341 (-3.3A)
None
None
 1.41A 3c6gB-2c2nA:
undetectable		 3c6gB-2c2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 LEU A 318
VAL A  96
GLY A 313
GLU A 311
VAL A 288
 AE4  A1346 ( 4.7A)
None
None
None
None
 1.01A 3c6gB-2c2nA:
undetectable		 3c6gB-2c2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 495
VAL A 515
GLY A 582
THR A 574
VAL A 566
 None
 1.14A 3c6gB-2d5lA:
undetectable		 3c6gB-2d5lA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE

(Variovorax sp.
Pal2) 		PF13714
(PEP_mutase) 		5 LEU A   7
ALA A  80
ALA A  71
VAL A  74
VAL A 209
 None
 1.10A 3c6gB-2duaA:
undetectable		 3c6gB-2duaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASN A 205
ALA A 212
GLY A 184
VAL A 228
THR A 225
 None
 1.10A 3c6gB-2f7lA:
undetectable		 3c6gB-2f7lA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		5 PHE A  18
ALA A  74
ALA A 395
THR A  54
VAL A  58
 None
 1.13A 3c6gB-2gqfA:
undetectable		 3c6gB-2gqfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		5 LEU A 161
ALA A  18
ALA A 146
GLY A 153
GLU A 152
 None
 1.10A 3c6gB-2imhA:
undetectable		 3c6gB-2imhA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 LEU A 206
PHE A 178
ALA A 111
ALA A 193
GLY A 269
 None
 1.12A 3c6gB-2inpA:
undetectable		 3c6gB-2inpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		6 LEU A 188
PHE A 303
VAL A 297
GLY A 300
GLU A 189
THR A 223
 None
 1.39A 3c6gB-2iuyA:
undetectable		 3c6gB-2iuyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 ALA A  70
ALA A  97
GLY A 218
GLU A 217
VAL A 352
 None
 1.06A 3c6gB-2nyfA:
undetectable		 3c6gB-2nyfA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		5 LEU A  57
ASN A  59
PHE A 535
GLY A  36
THR A 529
 None
 1.03A 3c6gB-2v8jA:
undetectable		 3c6gB-2v8jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		5 ALA A 360
VAL A 374
GLY A 354
GLU A 356
VAL A 348
 None
 1.09A 3c6gB-2wfdA:
undetectable		 3c6gB-2wfdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ALA A 253
ALA A  96
GLY A 101
GLU A 100
THR A 117
 None
 1.14A 3c6gB-2ys6A:
undetectable		 3c6gB-2ys6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 LEU A 371
ASN A 374
ALA A 382
THR A 283
VAL A 287
 None
 0.81A 3c6gB-3aqiA:
undetectable		 3c6gB-3aqiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 234
ALA A 250
ALA A 204
VAL A 178
GLY A 209
 None
 1.11A 3c6gB-3ddmA:
undetectable		 3c6gB-3ddmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 LEU X  76
PHE X 100
ALA X 253
GLU X  98
THR X  61
 None
 1.05A 3c6gB-3e13X:
undetectable		 3c6gB-3e13X:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A 330
ALA A 116
VAL A 111
GLU A  92
THR A 131
 None
 1.05A 3c6gB-3hjaA:
undetectable		 3c6gB-3hjaA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		5 ALA A 154
GLY A 166
THR A 214
VAL A 116
THR A 161
 None
 1.12A 3c6gB-3hpdA:
undetectable		 3c6gB-3hpdA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 PHE A 323
ALA A 334
ALA A 190
VAL A 187
GLY A 358
VAL A 233
 None
 1.24A 3c6gB-3hriA:
undetectable		 3c6gB-3hriA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 170
ALA A  54
ALA A 461
VAL A 460
GLY A  71
 None
 1.13A 3c6gB-3i8bA:
undetectable		 3c6gB-3i8bA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 ASN A 284
ALA A 161
ALA A  91
THR A 182
THR A 154
 None
 1.12A 3c6gB-3k2wA:
undetectable		 3c6gB-3k2wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF12524
(GlyL_C)
PF17488
(Herpes_glycoH_C) 		5 LEU A 310
ALA A 164
VAL B 145
GLY A 325
VAL A 246
 None
 1.15A 3c6gB-3m1cA:
undetectable		 3c6gB-3m1cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		5 LEU A  80
PHE A 104
ALA A 126
VAL A  91
GLY A  78
 Z69  A   1 ( 4.6A)
Z69  A   1 (-4.1A)
None
Z69  A   1 (-4.8A)
None
 1.11A 3c6gB-3mhaA:
undetectable		 3c6gB-3mhaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ALA A 353
VAL A 402
GLY A 396
VAL A 276
THR A 323
 None
 0.82A 3c6gB-3mkvA:
undetectable		 3c6gB-3mkvA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 LEU A 183
ASN A 179
ALA A 198
GLY A 190
THR A 264
 None
 0.99A 3c6gB-3mpnA:
undetectable		 3c6gB-3mpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwz BH2602 PROTEIN

(Bacillus
halodurans) 		PF03061
(4HBT) 		5 MET A  97
VAL A 133
GLY A 159
VAL A 154
THR A 153
 None
 1.05A 3c6gB-3nwzA:
undetectable		 3c6gB-3nwzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A  79
ALA A 338
VAL A 341
GLY A  10
VAL A  66
 None
 1.08A 3c6gB-3oytA:
undetectable		 3c6gB-3oytA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pef 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING

(Geobacter
metallireducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ALA A  63
GLY A  77
GLU A  73
THR A 101
VAL A  97
 None
None
NAP  A 301 (-3.7A)
None
None
 1.10A 3c6gB-3pefA:
undetectable		 3c6gB-3pefA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A  15
ALA A 120
ALA A 329
VAL A 333
THR A 111
 None
None
None
None
GOL  A 349 (-3.8A)
 0.99A 3c6gB-3pi7A:
undetectable		 3c6gB-3pi7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr1 PROBABLE GTP-BINDING
PROTEIN ENGB

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		5 LEU A 105
VAL A  66
GLY A  24
GLU A  25
THR A 137
 None
 1.13A 3c6gB-3pr1A:
undetectable		 3c6gB-3pr1A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3

(Homo sapiens) 		PF07686
(V-set) 		5 ALA B  91
ALA B  49
GLY B 116
GLU B 111
VAL B 107
 None
 1.06A 3c6gB-3pv6B:
undetectable		 3c6gB-3pv6B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 218
ALA A 262
ALA A 271
THR A 149
VAL A  34
 None
 1.02A 3c6gB-3pygA:
undetectable		 3c6gB-3pygA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 LEU A 145
ALA A 170
ALA A 230
GLY A 133
GLU A 132
 None
 1.04A 3c6gB-3qt4A:
undetectable		 3c6gB-3qt4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siv NHP2-LIKE PROTEIN 1

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		5 ALA A  39
ALA A  57
VAL A  83
THR A 105
THR A  45
 U  F  36 ( 3.1A)
None
None
None
None
 1.07A 3c6gB-3sivA:
undetectable		 3c6gB-3sivA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A  24
GLY A 275
THR A 190
VAL A 194
THR A 166
 None
None
LLP  A  51 ( 3.7A)
None
None
 1.14A 3c6gB-3tbhA:
undetectable		 3c6gB-3tbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 282
VAL A 269
THR A 174
VAL A 178
THR A 295
 None
 0.99A 3c6gB-3tbhA:
undetectable		 3c6gB-3tbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		5 ALA A  30
GLY A 319
THR A 324
VAL A 310
THR A 311
 None
 1.10A 3c6gB-3tghA:
undetectable		 3c6gB-3tghA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		5 ALA A   9
ALA A  47
GLY A  43
VAL A  66
THR A  70
 None
 1.13A 3c6gB-3votA:
undetectable		 3c6gB-3votA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		5 LEU A 252
ALA A 203
VAL A 136
GLY A 176
VAL A 126
 None
 0.98A 3c6gB-3vssA:
undetectable		 3c6gB-3vssA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 ALA A  73
ALA A 394
VAL A 329
GLU A 203
VAL A 211
 None
 1.11A 3c6gB-3wkhA:
undetectable		 3c6gB-3wkhA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		5 LEU A 465
PHE A 539
ALA A 514
VAL A 543
VAL A 490
 None
 1.11A 3c6gB-3zilA:
undetectable		 3c6gB-3zilA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 LEU A 106
ALA A  46
ALA A  22
VAL A  38
THR A  41
 None
 1.11A 3c6gB-3zizA:
undetectable		 3c6gB-3zizA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		5 LEU A 208
ALA A 155
ALA A 163
GLY A 166
THR A 115
 None
 1.14A 3c6gB-4ao7A:
undetectable		 3c6gB-4ao7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  60
ASN A  57
ALA A  96
VAL A 392
GLY A  19
 None
 0.80A 3c6gB-4bi9A:
undetectable		 3c6gB-4bi9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		6 LEU A  29
ASN A 116
PHE A 108
VAL A 296
GLY A  21
THR A  44
 None
 1.46A 3c6gB-4czpA:
undetectable		 3c6gB-4czpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 LEU A 286
ALA A  96
VAL A  99
GLY A 277
THR A 297
 None
 1.14A 3c6gB-4e77A:
undetectable		 3c6gB-4e77A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		5 PHE A 218
ALA A 136
VAL A 134
GLY A 152
VAL A 164
 None
 0.90A 3c6gB-4euoA:
undetectable		 3c6gB-4euoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fei HEAT SHOCK
PROTEIN-RELATED
PROTEIN

(Deinococcus
radiodurans) 		PF00011
(HSP20) 		5 LEU A  79
PHE A 136
VAL A 118
GLY A 123
VAL A  69
 None
 1.07A 3c6gB-4feiA:
undetectable		 3c6gB-4feiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 ALA A  92
ALA A 151
GLY A 145
VAL A 202
THR A 205
 None
 1.12A 3c6gB-4gs1A:
undetectable		 3c6gB-4gs1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		5 MET A   1
ALA A  27
GLY A  49
VAL A  72
THR A  86
 None
 1.10A 3c6gB-4h05A:
undetectable		 3c6gB-4h05A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqo ORNITHINE
CARBAMOYLTRANSFERASE

(Vibrio
vulnificus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  11
ASN A   9
ALA A  95
ALA A  50
GLY A 129
 None
 1.04A 3c6gB-4jqoA:
undetectable		 3c6gB-4jqoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 ALA A 334
ALA A 327
VAL A 322
GLY A 275
VAL A 366
 EDO  A 503 ( 4.0A)
None
None
None
None
 1.07A 3c6gB-4knaA:
undetectable		 3c6gB-4knaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liz ACTIN-BINDING
PROTEIN,
COFILIN/TROPOMYOSIN
FAMILY PROTEIN,
PUTATIVE

(Entamoeba
histolytica) 		PF00241
(Cofilin_ADF) 		5 LEU A  38
ALA A  59
ALA A  54
VAL A  51
VAL A  97
 None
EPE  A 201 ( 3.8A)
None
None
None
 1.13A 3c6gB-4lizA:
undetectable		 3c6gB-4lizA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 MET A 237
LEU A 343
PHE A 256
ALA A 334
ALA A 259
 None
 1.12A 3c6gB-4u33A:
undetectable		 3c6gB-4u33A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 128
PHE A 318
ALA A 378
ALA A 154
THR A 352
 3G6  A 402 ( 4.3A)
None
3G6  A 402 (-4.1A)
None
None
 1.04A 3c6gB-4ubtA:
undetectable		 3c6gB-4ubtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 PHE A 313
ALA A 108
GLY A 111
VAL A 152
THR A 153
 None
 1.09A 3c6gB-4w8vA:
undetectable		 3c6gB-4w8vA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		5 ALA A 102
VAL A 163
GLY A  72
GLU A 159
VAL A  40
 None
 1.08A 3c6gB-4xhcA:
undetectable		 3c6gB-4xhcA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE

(Glaciozyma
antarctica) 		PF00596
(Aldolase_II) 		5 LEU A 209
ALA A 129
ALA A 122
GLY A  69
VAL A 137
 None
 1.10A 3c6gB-4xxfA:
undetectable		 3c6gB-4xxfA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		5 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.09A 3c6gB-4xz7A:
undetectable		 3c6gB-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		5 ALA A 192
VAL A 195
GLY A 137
GLU A 176
THR A 183
 None
 0.99A 3c6gB-4y9aA:
undetectable		 3c6gB-4y9aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 MET A 637
LEU A 630
ALA A 601
ALA A 656
GLY A 664
 None
 1.08A 3c6gB-5affA:
undetectable		 3c6gB-5affA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 176
ASN A 173
ALA A 169
GLY A 187
THR A  91
 None
 1.14A 3c6gB-5b5sA:
undetectable		 3c6gB-5b5sA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 317
ALA A  -9
ALA A 107
VAL A 108
GLY A 304
 None
 1.12A 3c6gB-5by7A:
undetectable		 3c6gB-5by7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 287
ALA A 499
VAL A 496
GLY A 303
VAL A 297
 None
 1.07A 3c6gB-5cwaA:
undetectable		 3c6gB-5cwaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d76 PUTATIVE PHAGE LYSIN

(Streptococcus
phage phi7917) 		PF05257
(CHAP)
PF08460
(SH3_5) 		5 MET A  36
LEU A  45
ALA A   7
GLU A  34
THR A  91
 None
 1.14A 3c6gB-5d76A:
undetectable		 3c6gB-5d76A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 LEU B 635
ALA B 573
VAL B 538
GLY B 602
GLU B 601
 None
 1.11A 3c6gB-5do7B:
undetectable		 3c6gB-5do7B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ALA B  27
GLY B  56
THR A  10
VAL A  12
THR A  94
 None
 1.10A 3c6gB-5f1nB:
undetectable		 3c6gB-5f1nB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A 837
GLY A 952
GLU A 953
VAL A 798
THR A 794
 None
 1.15A 3c6gB-5fkuA:
undetectable		 3c6gB-5fkuA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		5 ALA A 256
GLU A 260
THR A 344
VAL A 308
THR A 350
 None
ZN  A 402 ( 3.7A)
None
None
None
 1.09A 3c6gB-5gneA:
undetectable		 3c6gB-5gneA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		5 LEU A 264
ALA A  38
ALA A  32
GLY A 272
THR A  55
 None
None
None
None
6GT  A 403 (-3.7A)
 1.07A 3c6gB-5j5dA:
undetectable		 3c6gB-5j5dA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 ALA A 367
ALA A 205
GLY A 186
THR A 155
VAL A 374
 None
None
6ZL  A 501 ( 4.4A)
URI  A 505 ( 4.5A)
URI  A 505 (-4.6A)
 1.09A 3c6gB-5l26A:
undetectable		 3c6gB-5l26A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 ALA A 154
ALA A 118
GLY A 432
GLU A 516
THR A 206
 None
 1.12A 3c6gB-5nsqA:
undetectable		 3c6gB-5nsqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o99 SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		no annotation 5 PHE B 519
ALA B 521
VAL B 524
GLY B 510
GLU B 509
 None
 1.12A 3c6gB-5o99B:
undetectable		 3c6gB-5o99B:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		5 ASN A 604
ALA A 673
VAL A 671
GLY A 666
VAL A 655
 None
 1.13A 3c6gB-5wx1A:
undetectable		 3c6gB-5wx1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC

(Pisum sativum) 		PF01716
(MSP) 		5 ASN O  27
PHE O 218
ALA O 112
GLU O  54
VAL O 116
 None
 1.12A 3c6gB-5xnlO:
undetectable		 3c6gB-5xnlO:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 143
ALA A 156
GLY A 147
VAL A 188
THR A 186
 None
None
NAD  A 402 (-3.3A)
None
None
 1.03A 3c6gB-5yu1A:
undetectable		 3c6gB-5yu1A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 5 LEU A 177
ALA A 238
VAL A 218
GLU A 228
VAL A 163
 None
 1.10A 3c6gB-6bk1A:
undetectable		 3c6gB-6bk1A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 ALA A 219
VAL A 402
GLY A 400
GLU A 226
THR A 358
 None
 1.07A 3c6gB-6bz0A:
undetectable		 3c6gB-6bz0A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c10 -

(-) 		no annotation 5 ALA A1287
VAL A1280
GLU A1330
THR A1361
VAL A1365
 None
 1.14A 3c6gB-6c10A:
undetectable		 3c6gB-6c10A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2

(Sulfobacillus) 		no annotation 5 ALA B 239
ALA B 268
THR B 107
VAL B  75
THR B 105
 None
 1.13A 3c6gB-6eqnB:
undetectable		 3c6gB-6eqnB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 5 LEU A 141
PHE A 368
ALA A 126
VAL A 280
GLY A 255
 None
 1.14A 3c6gB-6gk6A:
32.4		 3c6gB-6gk6A:
undetectable