SIMILAR PATTERNS OF AMINO ACIDS FOR 3C6G_A_VD3A701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R)
PF00285
(Citrate_synt)
5 LEU A 126
ALA A 195
ALA A 203
GLY A 105
ILE A 346
None
1.07A 3c6gA-1a59A:
0.0
3c6gA-1a59A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)


(Pyrococcus
woesei)
PF00382
(TFIIB)
5 LEU B1197
ALA B1140
ALA B1161
GLY B1187
ILE B1146
None
1.05A 3c6gA-1aisB:
0.2
3c6gA-1aisB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)


(Escherichia
coli)
PF00709
(Adenylsucc_synt)
5 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
None
0.85A 3c6gA-1cg4A:
0.0
3c6gA-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)


(Burkholderia
gladioli)
PF00144
(Beta-lactamase)
5 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
None
1.02A 3c6gA-1ci9A:
0.0
3c6gA-1ci9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Escherichia
coli)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 ALA A  84
ALA A 114
THR A   8
VAL A  10
ILE A  93
None
1.08A 3c6gA-1cqjA:
0.0
3c6gA-1cqjA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis)
PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C)
5 LEU A 260
LEU A 146
GLY A 201
VAL A 190
ILE A 148
None
1.07A 3c6gA-1cvrA:
0.0
3c6gA-1cvrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis)
PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C)
5 LEU A 260
LEU A 146
GLY A 202
VAL A 190
ILE A 148
None
0.97A 3c6gA-1cvrA:
0.0
3c6gA-1cvrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus)
PF00150
(Cellulase)
5 ASN A  59
ALA A 311
GLY A   3
VAL A 234
ILE A  23
None
1.07A 3c6gA-1eceA:
0.0
3c6gA-1eceA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE


(Moorella
thermoacetica)
PF01268
(FTHFS)
5 LEU A1088
ALA A1084
GLY A1403
ILE A1060
THR A1077
None
1.07A 3c6gA-1eg7A:
0.0
3c6gA-1eg7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3y DIADENOSINE
5',5'''-P1,P4-TETRAP
HOSPHATE HYDROLASE


(Lupinus
angustifolius)
PF00293
(NUDIX)
5 LEU A 121
ALA A  31
GLY A  45
VAL A 147
THR A 146
None
1.05A 3c6gA-1f3yA:
0.0
3c6gA-1f3yA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)
PROTEIN (LECTIN 1 B
CHAIN)


(Trichosanthes
kirilowii)
PF00161
(RIP)
PF00652
(Ricin_B_lectin)
5 LEU B 123
ALA B  26
GLY B 101
THR A 212
ILE B  62
None
1.03A 3c6gA-1ggpB:
undetectable
3c6gA-1ggpB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia)
PF00390
(malic)
PF03949
(Malic_M)
5 LEU A 221
LEU A 234
GLY A 141
VAL A 160
MET A 202
None
1.03A 3c6gA-1gq2A:
undetectable
3c6gA-1gq2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
5 ALA A 486
GLY A 284
THR A 228
VAL A 241
ILE A 200
None
FAD  A1031 (-3.6A)
None
None
None
1.02A 3c6gA-1h7wA:
undetectable
3c6gA-1h7wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE


(Escherichia
coli)
PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH)
6 LEU A 196
LEU A 157
ALA A 178
ALA A 203
THR A 260
ILE A 153
None
1.33A 3c6gA-1k82A:
undetectable
3c6gA-1k82A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN


(Enterovirus B)
PF00073
(Rhv)
5 LEU B 182
PHE A 194
THR A 246
VAL C  40
ILE C  46
None
1.06A 3c6gA-1mqtB:
undetectable
3c6gA-1mqtB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 LEU A1373
ALA A1397
ALA A1429
GLY A1390
ILE A1360
None
1.07A 3c6gA-1ofeA:
undetectable
3c6gA-1ofeA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw0 CONSERVED
HYPOTHETICAL PROTEIN


(Salmonella
enterica)
PF02578
(Cu-oxidase_4)
5 LEU A  11
ALA A  17
GLY A 213
THR A 104
VAL A 102
None
1.02A 3c6gA-1rw0A:
undetectable
3c6gA-1rw0A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis)
PF00118
(Cpn60_TCP1)
5 LEU A 234
ALA A 255
THR A 327
VAL A 320
ILE A 217
None
1.03A 3c6gA-1sjpA:
undetectable
3c6gA-1sjpA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 LEU A 231
ALA A 374
ALA A 176
VAL A 360
ILE A  35
LEU  A 231 ( 0.6A)
ALA  A 374 ( 0.0A)
ALA  A 176 ( 0.0A)
VAL  A 360 ( 0.6A)
ILE  A  35 ( 0.6A)
0.89A 3c6gA-1tedA:
undetectable
3c6gA-1tedA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2


(Streptomyces
coelicolor)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU B 387
PHE B 218
ALA B 306
GLY B 298
VAL B 291
None
0.95A 3c6gA-1tqyB:
undetectable
3c6gA-1tqyB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis)
PF01341
(Glyco_hydro_6)
5 LEU A 273
ALA A 245
ALA A 290
GLY A 297
VAL A 230
None
1.04A 3c6gA-1up2A:
undetectable
3c6gA-1up2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx0 TRANSALDOLASE

(Thermus
thermophilus)
PF00923
(TAL_FSA)
5 LEU A  22
ALA A 191
GLY A  61
THR A   7
MET A 193
None
1.08A 3c6gA-1wx0A:
undetectable
3c6gA-1wx0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum)
PF01095
(Pectinesterase)
5 LEU A 168
ALA A 136
ALA A 112
GLY A 150
ILE A 197
None
1.08A 3c6gA-1xg2A:
undetectable
3c6gA-1xg2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE


(Ipomoea batatas)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
5 LEU A 283
ALA A 157
GLY A 162
THR A 224
ILE A 246
None
0.90A 3c6gA-1xzwA:
undetectable
3c6gA-1xzwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2


(Pseudomonas
syringae)
PF01507
(PAPS_reduct)
5 LEU A  84
ALA A  46
GLY A 133
VAL A 205
ILE A  35
None
None
AGS  A 600 (-2.9A)
None
None
1.05A 3c6gA-1zunA:
undetectable
3c6gA-1zunA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE


(Pyrococcus
horikoshii)
PF00266
(Aminotran_5)
5 ASN A 155
ALA A 306
GLY A 107
ILE A 315
THR A 351
None
1.05A 3c6gA-2dr1A:
undetectable
3c6gA-2dr1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE


(Thermus
thermophilus)
PF01470
(Peptidase_C15)
5 LEU A 147
LEU A  62
ALA A 110
GLY A  65
VAL A 117
None
1.04A 3c6gA-2ebjA:
undetectable
3c6gA-2ebjA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4


(Escherichia
coli)
PF02113
(Peptidase_S13)
5 PHE A 315
ALA A 148
GLY A 332
VAL A 373
ILE A 348
None
0.99A 3c6gA-2exaA:
undetectable
3c6gA-2exaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C


(;
Homo sapiens)
no annotation 5 LEU A 396
ALA A 392
ALA B 165
GLY A 398
ILE A 358
None
1.00A 3c6gA-2gkwA:
undetectable
3c6gA-2gkwA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 293
ALA A 410
ALA A 127
GLY A 152
ILE A  44
None
None
CSO  A 126 ( 3.6A)
None
None
1.02A 3c6gA-2ibuA:
undetectable
3c6gA-2ibuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae)
no annotation 5 LEU B 298
ALA B 658
ALA B 558
GLY B 575
ILE B 285
None
0.97A 3c6gA-2j04B:
undetectable
3c6gA-2j04B:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z


(Saccharomyces
cerevisiae)
PF00125
(Histone)
PF16211
(Histone_H2A_C)
5 LEU A  48
LEU A 115
ALA A  65
GLY A 126
THR A 134
None
1.00A 3c6gA-2jssA:
undetectable
3c6gA-2jssA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]


(Salmonella
enterica)
PF00080
(Sod_Cu)
5 ALA A 149
ALA A  66
GLY A  71
VAL A   5
MET A   7
None
1.08A 3c6gA-2k4wA:
undetectable
3c6gA-2k4wA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica)
PF06917
(Pectate_lyase_2)
5 LEU A  57
ASN A  59
PHE A 535
GLY A  36
THR A 529
None
1.00A 3c6gA-2v8jA:
undetectable
3c6gA-2v8jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr3 CLUMPING FACTOR A

(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
6 LEU A 304
ALA A 331
ALA A 269
THR A 359
VAL A 241
ILE A 277
None
1.45A 3c6gA-2vr3A:
undetectable
3c6gA-2vr3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2r MATRIX PROTEIN

(Vesicular
stomatitis
virus)
PF06326
(Vesiculo_matrix)
5 LEU A 171
ASN A  93
ALA A  87
ALA A 109
GLY A 209
None
1.06A 3c6gA-2w2rA:
undetectable
3c6gA-2w2rA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF01494
(FAD_binding_3)
5 LEU A  49
ALA A  60
ALA A  64
GLY A  71
ILE A 309
None
1.07A 3c6gA-2x3nA:
undetectable
3c6gA-2x3nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE


(Chlorobaculum
tepidum)
PF07992
(Pyr_redox_2)
5 LEU A 268
THR A 110
VAL A 123
ILE A 125
THR A  18
FAD  A 361 (-4.5A)
None
None
None
None
1.05A 3c6gA-3ab1A:
undetectable
3c6gA-3ab1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE


(Methanothermobacter
thermautotrophicus)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
5 LEU A 531
ALA A 537
ALA A 520
GLY A 545
ILE A 505
None
1.05A 3c6gA-3aiiA:
undetectable
3c6gA-3aiiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens)
PF00762
(Ferrochelatase)
5 LEU A 371
ASN A 374
ALA A 382
THR A 283
VAL A 287
None
0.79A 3c6gA-3aqiA:
undetectable
3c6gA-3aqiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 LEU A 558
ALA A 519
GLY A 600
MET A 569
THR A 607
None
None
ZN  A 756 (-4.5A)
None
None
1.05A 3c6gA-3eqnA:
undetectable
3c6gA-3eqnA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis)
PF00149
(Metallophos)
5 LEU A  62
LEU A  56
ALA A 122
ILE A  44
THR A 320
None
1.05A 3c6gA-3gveA:
undetectable
3c6gA-3gveA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A


(Bartonella
henselae)
PF06026
(Rib_5-P_isom_A)
5 LEU A 177
ALA A 173
GLY A 229
ILE A 183
THR A 166
None
0.91A 3c6gA-3hheA:
undetectable
3c6gA-3hheA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
6 LEU A   7
PHE A  93
ALA A  57
GLY A  54
ILE A  29
THR A 100
None
None
None
IPE  A 300 (-2.9A)
None
None
1.39A 3c6gA-3k4yA:
undetectable
3c6gA-3k4yA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae)
PF02645
(DegV)
5 LEU A 167
ALA A 236
GLY A 270
ILE A 198
THR A 120
None
None
None
None
ELA  A 301 (-4.4A)
0.96A 3c6gA-3lupA:
undetectable
3c6gA-3lupA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae)
PF02645
(DegV)
5 LEU A 167
ALA A 275
ALA A 236
ILE A 198
THR A 120
None
ELA  A 301 ( 4.2A)
None
None
ELA  A 301 (-4.4A)
1.07A 3c6gA-3lupA:
undetectable
3c6gA-3lupA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB


(Bacillus
subtilis)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
5 LEU A 104
ALA A  70
ALA A 122
GLY A 116
ILE A 187
None
0.96A 3c6gA-3mfdA:
undetectable
3c6gA-3mfdA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus)
PF00209
(SNF)
5 LEU A 183
ASN A 179
ALA A 198
GLY A 190
THR A 264
None
1.00A 3c6gA-3mpnA:
undetectable
3c6gA-3mpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
5 LEU A 191
ALA A 201
GLY A 211
VAL A 104
ILE A 107
None
1.06A 3c6gA-3my7A:
undetectable
3c6gA-3my7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
5 LEU A 178
LEU A 162
ALA A 118
ALA A 109
GLY A 135
None
None
None
None
GOL  A 300 (-4.1A)
0.95A 3c6gA-3mybA:
undetectable
3c6gA-3mybA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
6 LEU A  39
LEU A  32
ALA A 136
ALA A 198
GLY A  35
ILE A  47
None
None
AP5  A 346 (-3.5A)
None
None
None
1.19A 3c6gA-3otxA:
undetectable
3c6gA-3otxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE


(Mycobacterium
tuberculosis)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 LEU A 218
ALA A 262
ALA A 271
THR A 149
VAL A  34
None
1.03A 3c6gA-3pygA:
undetectable
3c6gA-3pygA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE


(Mycoplana
ramosa)
PF00850
(Hist_deacetyl)
5 ASN A 173
ALA A 127
ALA A  33
GLY A 321
THR A 118
None
None
None
Q9C  A 401 (-3.6A)
None
0.93A 3c6gA-3q9cA:
undetectable
3c6gA-3q9cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE


(Klebsiella
pneumoniae)
PF01177
(Asp_Glu_race)
5 ALA A  78
ALA A  88
GLY A  67
ILE A  35
THR A  18
None
0.99A 3c6gA-3qvlA:
undetectable
3c6gA-3qvlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr3 BOLA

(Coxiella
burnetii)
PF01722
(BolA)
5 LEU A  55
ALA A  23
GLY A  14
VAL A   2
ILE A  63
None
0.92A 3c6gA-3tr3A:
undetectable
3c6gA-3tr3A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU


(Streptococcus
pneumoniae)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2)
5 LEU A 292
ALA A 329
GLY A 295
VAL A 266
ILE A 286
None
1.06A 3c6gA-4ac3A:
undetectable
3c6gA-4ac3A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE


(Trypanosoma
brucei)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A  52
LEU A  60
ASN A  57
ALA A  96
GLY A  19
None
0.98A 3c6gA-4bi9A:
undetectable
3c6gA-4bi9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
5 LEU B 138
ALA B 347
THR B 146
VAL B 112
ILE B 114
None
1.08A 3c6gA-4cakB:
undetectable
3c6gA-4cakB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE


(Oceanicola
granulosus)
PF00294
(PfkB)
5 LEU A 190
ALA A 281
GLY A 255
VAL A 125
ILE A 188
None
1.06A 3c6gA-4e69A:
undetectable
3c6gA-4e69A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2)
5 LEU A 171
GLY A 209
VAL A 163
ILE A 165
THR A 181
None
1.01A 3c6gA-4e79A:
undetectable
3c6gA-4e79A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE


(Mus musculus)
PF13091
(PLDc_2)
5 LEU A  84
PHE A  98
GLY A 104
VAL A 183
ILE A 165
None
0.92A 3c6gA-4ggjA:
undetectable
3c6gA-4ggjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
6 LEU M 100
LEU M 233
ALA M  29
ALA M  89
GLY M 324
ILE M  78
None
1.39A 3c6gA-4heaM:
undetectable
3c6gA-4heaM:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
5 LEU A  88
ALA A 122
ALA A  35
GLY A  16
THR A  66
None
None
None
NAI  A 301 ( 4.6A)
NAI  A 301 ( 4.5A)
1.03A 3c6gA-4ituA:
undetectable
3c6gA-4ituA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqo ORNITHINE
CARBAMOYLTRANSFERASE


(Vibrio
vulnificus)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 LEU A  11
ASN A   9
ALA A  95
ALA A  50
GLY A 129
None
1.05A 3c6gA-4jqoA:
undetectable
3c6gA-4jqoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN


(Rattus
norvegicus)
no annotation 5 LEU A 576
LEU A 501
ALA A 604
ALA A 594
GLY A 498
None
1.08A 3c6gA-4lc9A:
undetectable
3c6gA-4lc9A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA


(Homo sapiens)
PF00069
(Pkinase)
5 LEU E  41
ALA E  56
ALA E 110
GLY E  34
ILE E  59
None
1.07A 3c6gA-4md8E:
undetectable
3c6gA-4md8E:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN


(Marinobacter
hydrocarbonoclasticus)
PF13409
(GST_N_2)
PF14497
(GST_C_3)
5 ALA A  18
ALA A 172
GLY A   8
ILE A   3
THR A  25
None
0.91A 3c6gA-4n0vA:
undetectable
3c6gA-4n0vA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohc OROTATE
PHOSPHORIBOSYLTRANSF
ERASE


(Burkholderia
cenocepacia)
PF00156
(Pribosyltran)
5 LEU A 179
LEU A 127
ALA A 181
GLY A  80
ILE A  66
None
1.05A 3c6gA-4ohcA:
undetectable
3c6gA-4ohcA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C)
no annotation 5 ALA A 433
GLY A 444
THR A 490
VAL A 254
ILE A 376
None
1.06A 3c6gA-4qnlA:
undetectable
3c6gA-4qnlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE


(Escherichia
coli)
PF08003
(Methyltransf_9)
5 LEU A 156
PHE A  94
ALA A 163
MET A 289
THR A 286
None
1.07A 3c6gA-4qnxA:
undetectable
3c6gA-4qnxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 128
PHE A 318
ALA A 378
ALA A 154
THR A 352
3G6  A 402 ( 4.3A)
None
3G6  A 402 (-4.1A)
None
None
1.05A 3c6gA-4ubtA:
undetectable
3c6gA-4ubtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Shewanella
loihica)
PF01156
(IU_nuc_hydro)
5 LEU A 195
GLY A 171
THR A 320
VAL A 307
ILE A 230
None
CA  A 401 ( 4.1A)
None
None
None
0.96A 3c6gA-4wr2A:
undetectable
3c6gA-4wr2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE


(Stigmatella
aurantiaca)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 LEU A 287
ALA A 273
ALA A 304
GLY A 310
ILE A 255
None
1.07A 3c6gA-4wv3A:
undetectable
3c6gA-4wv3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
suis)
PF01841
(Transglut_core)
5 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
None
1.06A 3c6gA-4xz7A:
undetectable
3c6gA-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT


(Sulfurisphaera
tokodaii)
PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II)
5 LEU A 364
GLY A 317
THR A 313
VAL A 337
ILE A 327
None
0.93A 3c6gA-5b47A:
undetectable
3c6gA-5b47A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE


(Acinetobacter
baumannii)
PF01761
(DHQ_synthase)
5 LEU A  27
PHE A 123
GLY A 107
VAL A   6
ILE A  15
None
1.06A 3c6gA-5eksA:
undetectable
3c6gA-5eksA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN


(Canis lupus)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA B  27
GLY B  56
THR A  10
VAL A  12
THR A  94
None
1.07A 3c6gA-5f1nB:
undetectable
3c6gA-5f1nB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f42 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Francisella
tularensis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 LEU A 130
ALA A 164
ALA A 170
GLY A 135
ILE A 128
None
1.04A 3c6gA-5f42A:
undetectable
3c6gA-5f42A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus)
PF06441
(EHN)
5 LEU A 176
ALA A 338
GLY A 174
THR A 183
ILE A 307
None
5V4  A 408 (-3.5A)
None
None
None
1.04A 3c6gA-5f4zA:
undetectable
3c6gA-5f4zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA


(Lactobacillus
plantarum)
PF09861
(DUF2088)
5 ALA A 274
GLY A  24
VAL A 316
ILE A 314
THR A 283
None
1.03A 3c6gA-5huqA:
undetectable
3c6gA-5huqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE


(Cryptococcus
neoformans)
PF00709
(Adenylsucc_synt)
5 LEU A  96
ALA A  61
GLY A  41
VAL A 305
THR A 304
None
1.02A 3c6gA-5i33A:
undetectable
3c6gA-5i33A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM


(Escherichia
coli)
PF00884
(Sulfatase)
PF11893
(DUF3413)
5 LEU A 503
LEU A 494
ALA A 329
GLY A 308
ILE A 446
None
1.03A 3c6gA-5i5hA:
undetectable
3c6gA-5i5hA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME


(Brucella
melitensis)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 139
ALA A 214
GLY A 134
VAL A 119
ILE A 125
None
0.87A 3c6gA-5ijgA:
undetectable
3c6gA-5ijgA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Sinorhizobium
meliloti)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 LEU A 165
ALA A 155
THR A 177
ILE A 190
THR A 181
None
1.07A 3c6gA-5l0zA:
undetectable
3c6gA-5l0zA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii)
PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate)
5 ALA A 367
ALA A 205
GLY A 186
THR A 155
VAL A 374
None
None
6ZL  A 501 ( 4.4A)
URI  A 505 ( 4.5A)
URI  A 505 (-4.6A)
1.05A 3c6gA-5l26A:
undetectable
3c6gA-5l26A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  41
ALA A  56
ALA A 110
GLY A  34
ILE A  59
None
1.01A 3c6gA-5movA:
undetectable
3c6gA-5movA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 5 LEU B 154
ALA B 105
GLY B 819
THR B 494
ILE B 487
None
0.98A 3c6gA-5nd1B:
undetectable
3c6gA-5nd1B:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDF
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG


(Methanothermobacter
wolfeii)
PF00037
(Fer4)
PF12838
(Fer4_7)
5 LEU G   5
ALA G  21
GLY G  62
THR F  57
ILE G  76
SF4  G 102 ( 4.6A)
None
SF4  G 102 (-4.3A)
None
SF4  G 101 ( 3.8A)
1.07A 3c6gA-5t5iG:
undetectable
3c6gA-5t5iG:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE


(Mycolicibacterium
smegmatis)
PF07992
(Pyr_redox_2)
5 LEU A 307
ALA A 109
ALA A  26
GLY A 296
VAL A 253
None
1.08A 3c6gA-5uthA:
undetectable
3c6gA-5uthA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2


(Arabidopsis
thaliana)
no annotation 5 LEU A  28
LEU A  62
ALA A 292
ALA A  40
ILE A  14
None
0.95A 3c6gA-5vjwA:
undetectable
3c6gA-5vjwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2)
5 LEU A 295
GLY A 314
VAL A 287
ILE A 289
THR A 304
None
0.95A 3c6gA-5vmkA:
undetectable
3c6gA-5vmkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX


(unidentified)
no annotation 5 ASN A 161
ALA A 111
GLY A 100
ILE A 485
THR A 419
None
1.07A 3c6gA-5vqdA:
undetectable
3c6gA-5vqdA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 237
ALA A 258
THR A 330
VAL A 323
ILE A 220
None
0.99A 3c6gA-5w0sA:
undetectable
3c6gA-5w0sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE


(Escherichia
coli)
no annotation 5 LEU C 392
ASN C 395
VAL C 373
ILE C 362
THR C 370
None
0.91A 3c6gA-5wqlC:
undetectable
3c6gA-5wqlC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE


(Streptomyces
pristinaespiralis)
no annotation 5 LEU A 143
ALA A 156
GLY A 147
VAL A 188
THR A 186
None
None
NAD  A 402 (-3.3A)
None
None
1.03A 3c6gA-5yu1A:
undetectable
3c6gA-5yu1A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6


(Homo sapiens)
no annotation 5 LEU A 192
PHE A 186
ALA A 243
GLY A 162
THR A 237
None
1.06A 3c6gA-5yx9A:
undetectable
3c6gA-5yx9A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4)
no annotation 5 LEU B 145
LEU B  87
GLY B  89
VAL B 251
ILE B 247
None
1.06A 3c6gA-6c2jB:
undetectable
3c6gA-6c2jB:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE


(Klebsiella
pneumoniae)
no annotation 5 LEU A 428
ALA A 284
VAL A 415
ILE A 424
THR A 414
None
0.96A 3c6gA-6duxA:
undetectable
3c6gA-6duxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE


(Methanothermococcus
thermolithotrophicus)
no annotation 5 LEU A 216
ALA A 373
ALA A  86
GLY A 111
ILE A   6
None
1.03A 3c6gA-6et9A:
undetectable
3c6gA-6et9A:
10.76