SIMILAR PATTERNS OF AMINO ACIDS FOR 3C6G_A_VD3A701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 LEU A 126
ALA A 195
ALA A 203
GLY A 105
ILE A 346
 None
 1.07A 3c6gA-1a59A:
0.0		 3c6gA-1a59A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)

(Pyrococcus
woesei) 		PF00382
(TFIIB) 		5 LEU B1197
ALA B1140
ALA B1161
GLY B1187
ILE B1146
 None
 1.05A 3c6gA-1aisB:
0.2		 3c6gA-1aisB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
 None
 0.85A 3c6gA-1cg4A:
0.0		 3c6gA-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		5 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
 None
 1.02A 3c6gA-1ci9A:
0.0		 3c6gA-1ci9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ALA A  84
ALA A 114
THR A   8
VAL A  10
ILE A  93
 None
 1.08A 3c6gA-1cqjA:
0.0		 3c6gA-1cqjA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 LEU A 260
LEU A 146
GLY A 201
VAL A 190
ILE A 148
 None
 1.07A 3c6gA-1cvrA:
0.0		 3c6gA-1cvrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 LEU A 260
LEU A 146
GLY A 202
VAL A 190
ILE A 148
 None
 0.97A 3c6gA-1cvrA:
0.0		 3c6gA-1cvrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		5 ASN A  59
ALA A 311
GLY A   3
VAL A 234
ILE A  23
 None
 1.07A 3c6gA-1eceA:
0.0		 3c6gA-1eceA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		5 LEU A1088
ALA A1084
GLY A1403
ILE A1060
THR A1077
 None
 1.07A 3c6gA-1eg7A:
0.0		 3c6gA-1eg7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3y DIADENOSINE
5',5'''-P1,P4-TETRAP
HOSPHATE HYDROLASE

(Lupinus
angustifolius) 		PF00293
(NUDIX) 		5 LEU A 121
ALA A  31
GLY A  45
VAL A 147
THR A 146
 None
 1.05A 3c6gA-1f3yA:
0.0		 3c6gA-1f3yA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)
PROTEIN (LECTIN 1 B
CHAIN)

(Trichosanthes
kirilowii) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 LEU B 123
ALA B  26
GLY B 101
THR A 212
ILE B  62
 None
 1.03A 3c6gA-1ggpB:
undetectable		 3c6gA-1ggpB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 221
LEU A 234
GLY A 141
VAL A 160
MET A 202
 None
 1.03A 3c6gA-1gq2A:
undetectable		 3c6gA-1gq2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 ALA A 486
GLY A 284
THR A 228
VAL A 241
ILE A 200
 None
FAD  A1031 (-3.6A)
None
None
None
 1.02A 3c6gA-1h7wA:
undetectable		 3c6gA-1h7wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		6 LEU A 196
LEU A 157
ALA A 178
ALA A 203
THR A 260
ILE A 153
 None
 1.33A 3c6gA-1k82A:
undetectable		 3c6gA-1k82A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		5 LEU B 182
PHE A 194
THR A 246
VAL C  40
ILE C  46
 None
 1.06A 3c6gA-1mqtB:
undetectable		 3c6gA-1mqtB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1373
ALA A1397
ALA A1429
GLY A1390
ILE A1360
 None
 1.07A 3c6gA-1ofeA:
undetectable		 3c6gA-1ofeA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw0 CONSERVED
HYPOTHETICAL PROTEIN

(Salmonella
enterica) 		PF02578
(Cu-oxidase_4) 		5 LEU A  11
ALA A  17
GLY A 213
THR A 104
VAL A 102
 None
 1.02A 3c6gA-1rw0A:
undetectable		 3c6gA-1rw0A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 234
ALA A 255
THR A 327
VAL A 320
ILE A 217
 None
 1.03A 3c6gA-1sjpA:
undetectable		 3c6gA-1sjpA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 231
ALA A 374
ALA A 176
VAL A 360
ILE A  35
 LEU  A 231 ( 0.6A)
ALA  A 374 ( 0.0A)
ALA  A 176 ( 0.0A)
VAL  A 360 ( 0.6A)
ILE  A  35 ( 0.6A)
 0.89A 3c6gA-1tedA:
undetectable		 3c6gA-1tedA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 387
PHE B 218
ALA B 306
GLY B 298
VAL B 291
 None
 0.95A 3c6gA-1tqyB:
undetectable		 3c6gA-1tqyB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		5 LEU A 273
ALA A 245
ALA A 290
GLY A 297
VAL A 230
 None
 1.04A 3c6gA-1up2A:
undetectable		 3c6gA-1up2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx0 TRANSALDOLASE

(Thermus
thermophilus) 		PF00923
(TAL_FSA) 		5 LEU A  22
ALA A 191
GLY A  61
THR A   7
MET A 193
 None
 1.08A 3c6gA-1wx0A:
undetectable		 3c6gA-1wx0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 LEU A 168
ALA A 136
ALA A 112
GLY A 150
ILE A 197
 None
 1.08A 3c6gA-1xg2A:
undetectable		 3c6gA-1xg2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 LEU A 283
ALA A 157
GLY A 162
THR A 224
ILE A 246
 None
 0.90A 3c6gA-1xzwA:
undetectable		 3c6gA-1xzwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2

(Pseudomonas
syringae) 		PF01507
(PAPS_reduct) 		5 LEU A  84
ALA A  46
GLY A 133
VAL A 205
ILE A  35
 None
None
AGS  A 600 (-2.9A)
None
None
 1.05A 3c6gA-1zunA:
undetectable		 3c6gA-1zunA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 ASN A 155
ALA A 306
GLY A 107
ILE A 315
THR A 351
 None
 1.05A 3c6gA-2dr1A:
undetectable		 3c6gA-2dr1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		5 LEU A 147
LEU A  62
ALA A 110
GLY A  65
VAL A 117
 None
 1.04A 3c6gA-2ebjA:
undetectable		 3c6gA-2ebjA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		5 PHE A 315
ALA A 148
GLY A 332
VAL A 373
ILE A 348
 None
 0.99A 3c6gA-2exaA:
undetectable		 3c6gA-2exaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C

(;
Homo sapiens) 		no annotation 5 LEU A 396
ALA A 392
ALA B 165
GLY A 398
ILE A 358
 None
 1.00A 3c6gA-2gkwA:
undetectable		 3c6gA-2gkwA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 293
ALA A 410
ALA A 127
GLY A 152
ILE A  44
 None
None
CSO  A 126 ( 3.6A)
None
None
 1.02A 3c6gA-2ibuA:
undetectable		 3c6gA-2ibuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 298
ALA B 658
ALA B 558
GLY B 575
ILE B 285
 None
 0.97A 3c6gA-2j04B:
undetectable		 3c6gA-2j04B:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 LEU A  48
LEU A 115
ALA A  65
GLY A 126
THR A 134
 None
 1.00A 3c6gA-2jssA:
undetectable		 3c6gA-2jssA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		5 ALA A 149
ALA A  66
GLY A  71
VAL A   5
MET A   7
 None
 1.08A 3c6gA-2k4wA:
undetectable		 3c6gA-2k4wA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		5 LEU A  57
ASN A  59
PHE A 535
GLY A  36
THR A 529
 None
 1.00A 3c6gA-2v8jA:
undetectable		 3c6gA-2v8jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr3 CLUMPING FACTOR A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		6 LEU A 304
ALA A 331
ALA A 269
THR A 359
VAL A 241
ILE A 277
 None
 1.45A 3c6gA-2vr3A:
undetectable		 3c6gA-2vr3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2r MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		5 LEU A 171
ASN A  93
ALA A  87
ALA A 109
GLY A 209
 None
 1.06A 3c6gA-2w2rA:
undetectable		 3c6gA-2w2rA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		5 LEU A  49
ALA A  60
ALA A  64
GLY A  71
ILE A 309
 None
 1.07A 3c6gA-2x3nA:
undetectable		 3c6gA-2x3nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE

(Chlorobaculum
tepidum) 		PF07992
(Pyr_redox_2) 		5 LEU A 268
THR A 110
VAL A 123
ILE A 125
THR A  18
 FAD  A 361 (-4.5A)
None
None
None
None
 1.05A 3c6gA-3ab1A:
undetectable		 3c6gA-3ab1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 LEU A 531
ALA A 537
ALA A 520
GLY A 545
ILE A 505
 None
 1.05A 3c6gA-3aiiA:
undetectable		 3c6gA-3aiiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 LEU A 371
ASN A 374
ALA A 382
THR A 283
VAL A 287
 None
 0.79A 3c6gA-3aqiA:
undetectable		 3c6gA-3aqiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 LEU A 558
ALA A 519
GLY A 600
MET A 569
THR A 607
 None
None
ZN  A 756 (-4.5A)
None
None
 1.05A 3c6gA-3eqnA:
undetectable		 3c6gA-3eqnA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		5 LEU A  62
LEU A  56
ALA A 122
ILE A  44
THR A 320
 None
 1.05A 3c6gA-3gveA:
undetectable		 3c6gA-3gveA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A 177
ALA A 173
GLY A 229
ILE A 183
THR A 166
 None
 0.91A 3c6gA-3hheA:
undetectable		 3c6gA-3hheA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		6 LEU A   7
PHE A  93
ALA A  57
GLY A  54
ILE A  29
THR A 100
 None
None
None
IPE  A 300 (-2.9A)
None
None
 1.39A 3c6gA-3k4yA:
undetectable		 3c6gA-3k4yA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 LEU A 167
ALA A 236
GLY A 270
ILE A 198
THR A 120
 None
None
None
None
ELA  A 301 (-4.4A)
 0.96A 3c6gA-3lupA:
undetectable		 3c6gA-3lupA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 LEU A 167
ALA A 275
ALA A 236
ILE A 198
THR A 120
 None
ELA  A 301 ( 4.2A)
None
None
ELA  A 301 (-4.4A)
 1.07A 3c6gA-3lupA:
undetectable		 3c6gA-3lupA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A 104
ALA A  70
ALA A 122
GLY A 116
ILE A 187
 None
 0.96A 3c6gA-3mfdA:
undetectable		 3c6gA-3mfdA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 LEU A 183
ASN A 179
ALA A 198
GLY A 190
THR A 264
 None
 1.00A 3c6gA-3mpnA:
undetectable		 3c6gA-3mpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		5 LEU A 191
ALA A 201
GLY A 211
VAL A 104
ILE A 107
 None
 1.06A 3c6gA-3my7A:
undetectable		 3c6gA-3my7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 178
LEU A 162
ALA A 118
ALA A 109
GLY A 135
 None
None
None
None
GOL  A 300 (-4.1A)
 0.95A 3c6gA-3mybA:
undetectable		 3c6gA-3mybA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		6 LEU A  39
LEU A  32
ALA A 136
ALA A 198
GLY A  35
ILE A  47
 None
None
AP5  A 346 (-3.5A)
None
None
None
 1.19A 3c6gA-3otxA:
undetectable		 3c6gA-3otxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 218
ALA A 262
ALA A 271
THR A 149
VAL A  34
 None
 1.03A 3c6gA-3pygA:
undetectable		 3c6gA-3pygA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		5 ASN A 173
ALA A 127
ALA A  33
GLY A 321
THR A 118
 None
None
None
Q9C  A 401 (-3.6A)
None
 0.93A 3c6gA-3q9cA:
undetectable		 3c6gA-3q9cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		5 ALA A  78
ALA A  88
GLY A  67
ILE A  35
THR A  18
 None
 0.99A 3c6gA-3qvlA:
undetectable		 3c6gA-3qvlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr3 BOLA

(Coxiella
burnetii) 		PF01722
(BolA) 		5 LEU A  55
ALA A  23
GLY A  14
VAL A   2
ILE A  63
 None
 0.92A 3c6gA-3tr3A:
undetectable		 3c6gA-3tr3A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		5 LEU A 292
ALA A 329
GLY A 295
VAL A 266
ILE A 286
 None
 1.06A 3c6gA-4ac3A:
undetectable		 3c6gA-4ac3A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  52
LEU A  60
ASN A  57
ALA A  96
GLY A  19
 None
 0.98A 3c6gA-4bi9A:
undetectable		 3c6gA-4bi9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 LEU B 138
ALA B 347
THR B 146
VAL B 112
ILE B 114
 None
 1.08A 3c6gA-4cakB:
undetectable		 3c6gA-4cakB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 LEU A 190
ALA A 281
GLY A 255
VAL A 125
ILE A 188
 None
 1.06A 3c6gA-4e69A:
undetectable		 3c6gA-4e69A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 LEU A 171
GLY A 209
VAL A 163
ILE A 165
THR A 181
 None
 1.01A 3c6gA-4e79A:
undetectable		 3c6gA-4e79A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		5 LEU A  84
PHE A  98
GLY A 104
VAL A 183
ILE A 165
 None
 0.92A 3c6gA-4ggjA:
undetectable		 3c6gA-4ggjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		6 LEU M 100
LEU M 233
ALA M  29
ALA M  89
GLY M 324
ILE M  78
 None
 1.39A 3c6gA-4heaM:
undetectable		 3c6gA-4heaM:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 LEU A  88
ALA A 122
ALA A  35
GLY A  16
THR A  66
 None
None
None
NAI  A 301 ( 4.6A)
NAI  A 301 ( 4.5A)
 1.03A 3c6gA-4ituA:
undetectable		 3c6gA-4ituA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqo ORNITHINE
CARBAMOYLTRANSFERASE

(Vibrio
vulnificus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  11
ASN A   9
ALA A  95
ALA A  50
GLY A 129
 None
 1.05A 3c6gA-4jqoA:
undetectable		 3c6gA-4jqoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 576
LEU A 501
ALA A 604
ALA A 594
GLY A 498
 None
 1.08A 3c6gA-4lc9A:
undetectable		 3c6gA-4lc9A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU E  41
ALA E  56
ALA E 110
GLY E  34
ILE E  59
 None
 1.07A 3c6gA-4md8E:
undetectable		 3c6gA-4md8E:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN

(Marinobacter
hydrocarbonoclasticus) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		5 ALA A  18
ALA A 172
GLY A   8
ILE A   3
THR A  25
 None
 0.91A 3c6gA-4n0vA:
undetectable		 3c6gA-4n0vA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohc OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
cenocepacia) 		PF00156
(Pribosyltran) 		5 LEU A 179
LEU A 127
ALA A 181
GLY A  80
ILE A  66
 None
 1.05A 3c6gA-4ohcA:
undetectable		 3c6gA-4ohcA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 ALA A 433
GLY A 444
THR A 490
VAL A 254
ILE A 376
 None
 1.06A 3c6gA-4qnlA:
undetectable		 3c6gA-4qnlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE

(Escherichia
coli) 		PF08003
(Methyltransf_9) 		5 LEU A 156
PHE A  94
ALA A 163
MET A 289
THR A 286
 None
 1.07A 3c6gA-4qnxA:
undetectable		 3c6gA-4qnxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 128
PHE A 318
ALA A 378
ALA A 154
THR A 352
 3G6  A 402 ( 4.3A)
None
3G6  A 402 (-4.1A)
None
None
 1.05A 3c6gA-4ubtA:
undetectable		 3c6gA-4ubtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		5 LEU A 195
GLY A 171
THR A 320
VAL A 307
ILE A 230
 None
CA  A 401 ( 4.1A)
None
None
None
 0.96A 3c6gA-4wr2A:
undetectable		 3c6gA-4wr2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 287
ALA A 273
ALA A 304
GLY A 310
ILE A 255
 None
 1.07A 3c6gA-4wv3A:
undetectable		 3c6gA-4wv3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		5 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.06A 3c6gA-4xz7A:
undetectable		 3c6gA-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		5 LEU A 364
GLY A 317
THR A 313
VAL A 337
ILE A 327
 None
 0.93A 3c6gA-5b47A:
undetectable		 3c6gA-5b47A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		5 LEU A  27
PHE A 123
GLY A 107
VAL A   6
ILE A  15
 None
 1.06A 3c6gA-5eksA:
undetectable		 3c6gA-5eksA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ALA B  27
GLY B  56
THR A  10
VAL A  12
THR A  94
 None
 1.07A 3c6gA-5f1nB:
undetectable		 3c6gA-5f1nB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f42 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Francisella
tularensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 LEU A 130
ALA A 164
ALA A 170
GLY A 135
ILE A 128
 None
 1.04A 3c6gA-5f42A:
undetectable		 3c6gA-5f42A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 176
ALA A 338
GLY A 174
THR A 183
ILE A 307
 None
5V4  A 408 (-3.5A)
None
None
None
 1.04A 3c6gA-5f4zA:
undetectable		 3c6gA-5f4zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		5 ALA A 274
GLY A  24
VAL A 316
ILE A 314
THR A 283
 None
 1.03A 3c6gA-5huqA:
undetectable		 3c6gA-5huqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		5 LEU A  96
ALA A  61
GLY A  41
VAL A 305
THR A 304
 None
 1.02A 3c6gA-5i33A:
undetectable		 3c6gA-5i33A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 LEU A 503
LEU A 494
ALA A 329
GLY A 308
ILE A 446
 None
 1.03A 3c6gA-5i5hA:
undetectable		 3c6gA-5i5hA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 139
ALA A 214
GLY A 134
VAL A 119
ILE A 125
 None
 0.87A 3c6gA-5ijgA:
undetectable		 3c6gA-5ijgA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A 165
ALA A 155
THR A 177
ILE A 190
THR A 181
 None
 1.07A 3c6gA-5l0zA:
undetectable		 3c6gA-5l0zA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 ALA A 367
ALA A 205
GLY A 186
THR A 155
VAL A 374
 None
None
6ZL  A 501 ( 4.4A)
URI  A 505 ( 4.5A)
URI  A 505 (-4.6A)
 1.05A 3c6gA-5l26A:
undetectable		 3c6gA-5l26A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  41
ALA A  56
ALA A 110
GLY A  34
ILE A  59
 None
 1.01A 3c6gA-5movA:
undetectable		 3c6gA-5movA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 LEU B 154
ALA B 105
GLY B 819
THR B 494
ILE B 487
 None
 0.98A 3c6gA-5nd1B:
undetectable		 3c6gA-5nd1B:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDF
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG

(Methanothermobacter
wolfeii) 		PF00037
(Fer4)
PF12838
(Fer4_7) 		5 LEU G   5
ALA G  21
GLY G  62
THR F  57
ILE G  76
 SF4  G 102 ( 4.6A)
None
SF4  G 102 (-4.3A)
None
SF4  G 101 ( 3.8A)
 1.07A 3c6gA-5t5iG:
undetectable		 3c6gA-5t5iG:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF07992
(Pyr_redox_2) 		5 LEU A 307
ALA A 109
ALA A  26
GLY A 296
VAL A 253
 None
 1.08A 3c6gA-5uthA:
undetectable		 3c6gA-5uthA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 5 LEU A  28
LEU A  62
ALA A 292
ALA A  40
ILE A  14
 None
 0.95A 3c6gA-5vjwA:
undetectable		 3c6gA-5vjwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		5 LEU A 295
GLY A 314
VAL A 287
ILE A 289
THR A 304
 None
 0.95A 3c6gA-5vmkA:
undetectable		 3c6gA-5vmkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 5 ASN A 161
ALA A 111
GLY A 100
ILE A 485
THR A 419
 None
 1.07A 3c6gA-5vqdA:
undetectable		 3c6gA-5vqdA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A 237
ALA A 258
THR A 330
VAL A 323
ILE A 220
 None
 0.99A 3c6gA-5w0sA:
undetectable		 3c6gA-5w0sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 5 LEU C 392
ASN C 395
VAL C 373
ILE C 362
THR C 370
 None
 0.91A 3c6gA-5wqlC:
undetectable		 3c6gA-5wqlC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 143
ALA A 156
GLY A 147
VAL A 188
THR A 186
 None
None
NAD  A 402 (-3.3A)
None
None
 1.03A 3c6gA-5yu1A:
undetectable		 3c6gA-5yu1A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 5 LEU A 192
PHE A 186
ALA A 243
GLY A 162
THR A 237
 None
 1.06A 3c6gA-5yx9A:
undetectable		 3c6gA-5yx9A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 5 LEU B 145
LEU B  87
GLY B  89
VAL B 251
ILE B 247
 None
 1.06A 3c6gA-6c2jB:
undetectable		 3c6gA-6c2jB:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 5 LEU A 428
ALA A 284
VAL A 415
ILE A 424
THR A 414
 None
 0.96A 3c6gA-6duxA:
undetectable		 3c6gA-6duxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU A 216
ALA A 373
ALA A  86
GLY A 111
ILE A   6
 None
 1.03A 3c6gA-6et9A:
undetectable		 3c6gA-6et9A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 MET A 241
VAL A 352
GLU A 118
 None
 0.86A 3c6gA-1crkA:
0.0		 3c6gA-1crkA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 MET A 471
VAL A 506
GLU A 501
 None
 0.86A 3c6gA-1ddgA:
0.0		 3c6gA-1ddgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 MET A 528
VAL A 398
GLU A 531
 None
 0.89A 3c6gA-1gpeA:
0.0		 3c6gA-1gpeA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Leishmania
mexicana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 MET A 146
VAL A 161
GLU A 152
 None
 0.90A 3c6gA-1gyqA:
0.0		 3c6gA-1gyqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		3 MET A 385
VAL A 408
GLU A 403
 None
 0.69A 3c6gA-1qsaA:
0.0		 3c6gA-1qsaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		3 MET A 367
VAL A 362
GLU A 380
 None
 0.81A 3c6gA-1rh9A:
0.0		 3c6gA-1rh9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 MET A 255
VAL A 313
GLU A 261
 None
 0.71A 3c6gA-1rpnA:
undetectable		 3c6gA-1rpnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		3 MET A 727
VAL A 759
GLU A 784
 None
 0.86A 3c6gA-1suuA:
0.0		 3c6gA-1suuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3v CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF02579
(Nitro_FeMo-Co) 		3 MET A  84
VAL A  68
GLU A  82
 None
 0.76A 3c6gA-1t3vA:
0.0		 3c6gA-1t3vA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 MET A 288
VAL A 258
GLU A 209
 None
 0.91A 3c6gA-1ulzA:
undetectable		 3c6gA-1ulzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		3 MET A  71
VAL A  93
GLU A  66
 None
 0.66A 3c6gA-1v5xA:
undetectable		 3c6gA-1v5xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		3 MET A 213
VAL A 302
GLU A 218
 None
 0.81A 3c6gA-1xkdA:
undetectable		 3c6gA-1xkdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		3 MET A 289
VAL A 281
GLU A 259
 None
 0.85A 3c6gA-1xr4A:
undetectable		 3c6gA-1xr4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6z HEAT SHOCK PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00183
(HSP90) 		3 MET A 134
VAL A 174
GLU A 169
 None
 0.87A 3c6gA-1y6zA:
undetectable		 3c6gA-1y6zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		3 MET A  47
VAL A 104
GLU A  95
 None
 0.69A 3c6gA-1y8pA:
undetectable		 3c6gA-1y8pA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 MET A 506
VAL A 532
GLU A 491
 None
 0.86A 3c6gA-2b8eA:
undetectable		 3c6gA-2b8eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjo ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
OHRB

(Bacillus
subtilis) 		PF02566
(OsmC) 		3 MET A  82
VAL A 129
GLU A  45
 None
 0.69A 3c6gA-2bjoA:
undetectable		 3c6gA-2bjoA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		3 MET A 155
VAL A 169
GLU A 255
 None
 0.87A 3c6gA-2e3dA:
undetectable		 3c6gA-2e3dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257

(Bacteroides
thetaiotaomicron) 		PF01661
(Macro) 		3 MET A  79
VAL A  20
GLU A 106
 None
 0.82A 3c6gA-2fg1A:
undetectable		 3c6gA-2fg1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		3 MET A1864
VAL A1450
GLU A1867
 None
 0.75A 3c6gA-2fr1A:
undetectable		 3c6gA-2fr1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		3 MET A 295
VAL A 248
GLU A 257
 None
 0.67A 3c6gA-2i99A:
undetectable		 3c6gA-2i99A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 MET A 159
VAL A 152
GLU A 255
 None
 0.86A 3c6gA-2j1qA:
undetectable		 3c6gA-2j1qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvl TRMBF1

(Trichoderma
reesei) 		PF01381
(HTH_3) 		3 MET A  98
VAL A 135
GLU A  95
 None
 0.91A 3c6gA-2jvlA:
undetectable		 3c6gA-2jvlA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 MET B 125
VAL B 189
GLU B 185
 None
 0.71A 3c6gA-2po2B:
undetectable		 3c6gA-2po2B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE

(Paraburkholderia
xenovorans) 		PF02627
(CMD) 		3 MET A  92
VAL A  72
GLU A 100
 None
 0.90A 3c6gA-2qeuA:
undetectable		 3c6gA-2qeuA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 MET A 406
VAL A 402
GLU A 383
 None
 0.90A 3c6gA-2vbiA:
undetectable		 3c6gA-2vbiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 MET J 506
VAL J 532
GLU J 491
 None
 0.87A 3c6gA-2voyJ:
undetectable		 3c6gA-2voyJ:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw NRFC PROTEIN
THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF13247
(Fer4_11) 		3 MET B  25
VAL A  62
GLU A  66
 None
 0.70A 3c6gA-2vpwB:
undetectable		 3c6gA-2vpwB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 MET A 410
VAL A 406
GLU A 387
 None
 0.83A 3c6gA-2wvgA:
undetectable		 3c6gA-2wvgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		3 MET A 501
VAL A 488
GLU A 431
 None
 0.84A 3c6gA-2xdfA:
undetectable		 3c6gA-2xdfA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		3 MET A  10
VAL A1001
GLU A   7
 None
 0.91A 3c6gA-3auxA:
undetectable		 3c6gA-3auxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d34 SPONDIN-2

(Homo sapiens) 		PF06468
(Spond_N) 		3 MET A  57
VAL A  97
GLU A  83
 None
 0.86A 3c6gA-3d34A:
undetectable		 3c6gA-3d34A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 MET A1469
VAL A1507
GLU A1466
 None
 0.87A 3c6gA-3gd7A:
undetectable		 3c6gA-3gd7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge6 NITROREDUCTASE

(Exiguobacterium
sibiricum) 		PF00881
(Nitroreductase) 		3 MET A  33
VAL A 151
GLU A  38
 None
 0.78A 3c6gA-3ge6A:
undetectable		 3c6gA-3ge6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gge PDZ
DOMAIN-CONTAINING
PROTEIN GIPC2

(Homo sapiens) 		PF00595
(PDZ) 		3 MET A 193
VAL A 178
GLU A 163
 None
 0.91A 3c6gA-3ggeA:
undetectable		 3c6gA-3ggeA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00239
(Resolvase) 		3 MET A  32
VAL A  80
GLU A  46
 None
 0.88A 3c6gA-3guvA:
undetectable		 3c6gA-3guvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkm OS03G0854200 PROTEIN

(Oryza sativa) 		PF01138
(RNase_PH) 		3 MET A 203
VAL A 151
GLU A 206
 None
 0.73A 3c6gA-3hkmA:
undetectable		 3c6gA-3hkmA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iic CHEC DOMAIN PROTEIN

(Shewanella
loihica) 		PF13690
(CheX) 		3 MET A  73
VAL A  85
GLU A  68
 None
 0.91A 3c6gA-3iicA:
undetectable		 3c6gA-3iicA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		3 MET A 506
VAL A 532
GLU A 491
 None
 0.87A 3c6gA-3j09A:
undetectable		 3c6gA-3j09A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln6 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Streptococcus
agalactiae) 		PF01071
(GARS_A)
PF04262
(Glu_cys_ligase) 		3 MET A 688
VAL A 695
GLU A 686
 None
 0.74A 3c6gA-3ln6A:
undetectable		 3c6gA-3ln6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 MET A 331
VAL A  22
GLU A 343
 None
None
K  A 408 (-3.5A)
 0.91A 3c6gA-3oytA:
undetectable		 3c6gA-3oytA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pry HEAT SHOCK PROTEIN
HSP 90-BETA

(Homo sapiens) 		PF00183
(HSP90) 		3 MET A 466
VAL A 511
GLU A 471
 None
 0.91A 3c6gA-3pryA:
undetectable		 3c6gA-3pryA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 3 MET A 323
VAL A 318
GLU A 328
 None
 0.82A 3c6gA-3q3hA:
undetectable		 3c6gA-3q3hA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		3 MET A 482
VAL A 475
GLU A 456
 None
 0.88A 3c6gA-3q4tA:
undetectable		 3c6gA-3q4tA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		3 MET A 262
VAL A 371
GLU A 267
 None
 0.56A 3c6gA-3qi6A:
undetectable		 3c6gA-3qi6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		3 MET A 123
VAL A 198
GLU A  62
 None
 0.84A 3c6gA-3r97A:
undetectable		 3c6gA-3r97A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 MET A 260
VAL A 298
GLU A 257
 None
 0.59A 3c6gA-3rlfA:
undetectable		 3c6gA-3rlfA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		3 MET A  44
VAL A  13
GLU A   8
 None
 0.81A 3c6gA-3rplA:
undetectable		 3c6gA-3rplA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdm COMPUTATIONALLY
DESIGNED TWO-FOLD
SYMMETRIC TIM-BARREL
PROTEIN, FLR (HALF
MOLECULE)

(synthetic
construct) 		PF00977
(His_biosynth) 		3 MET A  86
VAL A 100
GLU A  91
 None
 0.89A 3c6gA-3tdmA:
undetectable		 3c6gA-3tdmA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz1 TROPONIN C

(Chlamys
nipponensis) 		PF13499
(EF-hand_7) 		3 MET A 147
VAL A 138
GLU A 129
 None
 0.83A 3c6gA-3tz1A:
undetectable		 3c6gA-3tz1A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		3 MET A  90
VAL A  43
GLU A  47
 None
 0.75A 3c6gA-3u37A:
undetectable		 3c6gA-3u37A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 MET A 282
VAL A 317
GLU A 109
 None
 0.77A 3c6gA-3u9iA:
undetectable		 3c6gA-3u9iA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 MET A 397
VAL A 465
GLU A 402
 None
 0.70A 3c6gA-3vteA:
undetectable		 3c6gA-3vteA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		3 MET A  75
VAL A  71
GLU A  79
 None
None
GOL  A1246 (-3.1A)
 0.83A 3c6gA-4aejA:
undetectable		 3c6gA-4aejA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		3 MET A 294
VAL A 247
GLU A 256
 None
None
T3  A1314 (-3.7A)
 0.72A 3c6gA-4bvaA:
undetectable		 3c6gA-4bvaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 MET A 575
VAL A 616
GLU A 578
 None
 0.90A 3c6gA-4cgyA:
undetectable		 3c6gA-4cgyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 MET A 406
VAL A 402
GLU A 383
 None
 0.86A 3c6gA-4cokA:
undetectable		 3c6gA-4cokA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		3 MET A 155
VAL A 169
GLU A 255
 None
 0.87A 3c6gA-4d48A:
undetectable		 3c6gA-4d48A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		3 MET A 202
VAL A  23
GLU A  99
 None
None
EDO  A 404 (-4.1A)
 0.81A 3c6gA-4ed9A:
undetectable		 3c6gA-4ed9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		3 MET A  62
VAL A  33
GLU A  67
 None
 0.89A 3c6gA-4evzA:
undetectable		 3c6gA-4evzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 MET A 288
VAL A 182
GLU A 115
 None
 0.82A 3c6gA-4eyeA:
undetectable		 3c6gA-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		3 MET A 278
VAL A 238
GLU A 258
 None
 0.75A 3c6gA-4f0lA:
undetectable		 3c6gA-4f0lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		3 MET A 646
VAL A 649
GLU A 661
 None
 0.75A 3c6gA-4f1nA:
undetectable		 3c6gA-4f1nA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		3 MET A 907
VAL A 953
GLU A 913
 None
 0.90A 3c6gA-4fc2A:
undetectable		 3c6gA-4fc2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		3 MET A 358
VAL A 435
GLU A 390
 None
 0.77A 3c6gA-4fx5A:
undetectable		 3c6gA-4fx5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF12667
(NigD_N)
PF17415
(NigD_C) 		3 MET A 159
VAL A 107
GLU A 175
 None
 0.74A 3c6gA-4j8qA:
undetectable		 3c6gA-4j8qA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		3 MET A 298
VAL A 375
GLU A 372
 None
 0.90A 3c6gA-4narA:
undetectable		 3c6gA-4narA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		3 MET A 233
VAL A 473
GLU A 228
 None
 0.71A 3c6gA-4oerA:
undetectable		 3c6gA-4oerA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		3 MET A 939
VAL A1026
GLU A1021
 None
 0.91A 3c6gA-4um2A:
undetectable		 3c6gA-4um2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcw RIBOSOMAL SILENCING
FACTOR RSFS

(Mycobacterium
tuberculosis) 		PF02410
(RsfS) 		3 MET A  63
VAL A  91
GLU A  58
 None
 0.86A 3c6gA-4wcwA:
undetectable		 3c6gA-4wcwA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		3 MET A 342
VAL A 225
GLU A 196
 None
 0.91A 3c6gA-4x8iA:
undetectable		 3c6gA-4x8iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 MET A 327
VAL A  22
GLU A 339
 None
 0.87A 3c6gA-4xoxA:
undetectable		 3c6gA-4xoxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		3 MET A 261
VAL A 216
GLU A 143
 None
 0.68A 3c6gA-4ywhA:
undetectable		 3c6gA-4ywhA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		3 MET A 109
VAL A 117
GLU A 187
 None
 0.79A 3c6gA-4zcfA:
undetectable		 3c6gA-4zcfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		3 MET A  44
VAL A  13
GLU A   8
 None
 0.71A 3c6gA-5a5lA:
undetectable		 3c6gA-5a5lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 MET A 681
VAL A 620
GLU A 653
 None
 0.89A 3c6gA-5cj5A:
undetectable		 3c6gA-5cj5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 MET A 224
VAL A 347
GLU A 321
 None
None
ZN  A 401 ( 2.3A)
 0.89A 3c6gA-5cnxA:
undetectable		 3c6gA-5cnxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dus ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		3 MET A 114
VAL A  14
GLU A 144
 None
 0.89A 3c6gA-5dusA:
undetectable		 3c6gA-5dusA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejb FUSION GLYCOPROTEIN
F0

(Hendra
henipavirus) 		no annotation 3 MET B  76
VAL B  68
GLU B 196
 None
 0.60A 3c6gA-5ejbB:
undetectable		 3c6gA-5ejbB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		3 MET A 255
VAL A 296
GLU A 253
 None
 0.87A 3c6gA-5eqjA:
undetectable		 3c6gA-5eqjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2h UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF02230
(Abhydrolase_2) 		3 MET A  65
VAL A 100
GLU A  95
 None
 0.82A 3c6gA-5f2hA:
undetectable		 3c6gA-5f2hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		3 MET A 196
VAL A 251
GLU A 225
 None
 0.86A 3c6gA-5ha5A:
undetectable		 3c6gA-5ha5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl6 PUTATIVE GAF SENSOR
PROTEIN

(Burkholderia
vietnamiensis) 		PF13185
(GAF_2) 		3 MET A 150
VAL A  96
GLU A 145
 None
 0.90A 3c6gA-5hl6A:
undetectable		 3c6gA-5hl6A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 3 MET B 428
VAL B  81
GLU B 190
 None
 0.74A 3c6gA-5i61B:
undetectable		 3c6gA-5i61B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		3 MET A 143
VAL A 157
GLU A 148
 None
 0.88A 3c6gA-5j49A:
undetectable		 3c6gA-5j49A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnz BETA CHAIN

(Acipenser
stellatus) 		PF00042
(Globin) 		3 MET B 133
VAL B  12
GLU B   7
 None
 0.85A 3c6gA-5jnzB:
undetectable		 3c6gA-5jnzB:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 MET A1411
VAL A1366
GLU A1406
 None
 0.90A 3c6gA-5me3A:
undetectable		 3c6gA-5me3A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 MET A 252
VAL A 267
GLU A 257
 None
 0.91A 3c6gA-5nv3A:
undetectable		 3c6gA-5nv3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 MET A 758
VAL A 712
GLU A 753
 None
 0.68A 3c6gA-5uj7A:
undetectable		 3c6gA-5uj7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 MET A 758
VAL A 712
GLU A 753
 None
 0.69A 3c6gA-5ujmA:
undetectable		 3c6gA-5ujmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 MET A 317
VAL A 310
GLU A 285
 None
 0.87A 3c6gA-5uv2A:
undetectable		 3c6gA-5uv2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veg FLAVODOXIN

(Lactobacillus
reuteri) 		no annotation 3 MET A  64
VAL A  54
GLU A  67
 None
 0.77A 3c6gA-5vegA:
undetectable		 3c6gA-5vegA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		3 MET A 179
VAL A 212
GLU A 244
 None
 0.60A 3c6gA-5volA:
undetectable		 3c6gA-5volA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywo 2F2 HEAVY CHAIN

(Mus musculus) 		no annotation 3 MET N  34
VAL N 107
GLU N   6
 None
 0.91A 3c6gA-5ywoN:
undetectable		 3c6gA-5ywoN:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 3 MET A   1
VAL A   6
GLU A  42
 None
 0.58A 3c6gA-5z7rA:
undetectable		 3c6gA-5z7rA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 3 MET A 795
VAL A 788
GLU A 802
 None
 0.91A 3c6gA-6b3yA:
undetectable		 3c6gA-6b3yA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bha CASPASE-3

(Homo sapiens) 		no annotation 3 MET A 100
VAL A 134
GLU A  98
 None
 0.88A 3c6gA-6bhaA:
undetectable		 3c6gA-6bhaA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 MET A 547
VAL A 576
GLU A 602
 None
 0.78A 3c6gA-6eonA:
undetectable		 3c6gA-6eonA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 MET D 247
VAL D  77
GLU D 284
 None
 0.80A 3c6gA-6fkhD:
undetectable		 3c6gA-6fkhD:
12.85