SIMILAR PATTERNS OF AMINO ACIDS FOR 3C0Z_C_SHHC301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ako | EXONUCLEASE III (Escherichiacoli) |
PF03372(Exo_endo_phos) | 4 | ASP A 214ASP A 229HIS A 259ASP A 151 | None | 1.12A | 3c0zC-1akoA:undetectable | 3c0zC-1akoA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 5 | HIS A 131HIS A 132ASP A 168HIS A 170ASP A 258 | TSN A 502 (-4.0A)TSN A 502 (-3.9A) ZN A 501 ( 2.3A) ZN A 501 ( 3.1A) ZN A 501 ( 2.5A) | 0.28A | 3c0zC-1c3rA:39.1 | 3c0zC-1c3rA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e33 | ARYLSULFATASE A (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 4 | ASP P 173HIS P 151ASP P 29HIS P 229 | NoneNone MG P 603 (-3.1A)None | 1.15A | 3c0zC-1e33P:2.4 | 3c0zC-1e33P:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i74 | PROBABLEMANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusmutans) |
PF01368(DHH)PF02833(DHHA2) | 4 | HIS A 97HIS A 98ASP A 149ASP A 12 | MN A 402 ( 3.6A)SO4 A 405 (-3.8A) MN A 402 ( 2.6A) MN A 401 ( 2.0A) | 1.10A | 3c0zC-1i74A:undetectable | 3c0zC-1i74A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 4 | ASP A 40HIS A 126HIS A 61ASP A 201 | None | 0.94A | 3c0zC-1j6oA:undetectable | 3c0zC-1j6oA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 4 | ASP A 64HIS A 151HIS A 126ASP A 201 | None | 1.14A | 3c0zC-1j6oA:undetectable | 3c0zC-1j6oA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k20 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusgordonii) |
PF01368(DHH)PF02833(DHHA2) | 4 | HIS A 99HIS A 100ASP A 151ASP A 13 | MN A 702 (-3.2A)SO4 A 705 (-3.9A) MN A 702 (-2.8A) MN A 701 (-2.2A) | 1.05A | 3c0zC-1k20A:undetectable | 3c0zC-1k20A:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 4 | HIS A 12HIS A 211ASP A 292ASP A 293 | ZN A 501 ( 3.3A) ZN A 501 ( 3.4A)PRH A 401 ( 2.5A)PRH A 401 (-3.5A) | 1.20A | 3c0zC-1krmA:undetectable | 3c0zC-1krmA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lbu | MURAMOYL-PENTAPEPTIDE CARBOXYPEPTIDASE (Streptomycesalbus) |
PF01471(PG_binding_1)PF08291(Peptidase_M15_3) | 4 | HIS A 195HIS A 192ASP A 161HIS A 197 | NoneNone ZN A 214 ( 2.3A) ZN A 214 ( 3.3A) | 0.96A | 3c0zC-1lbuA:undetectable | 3c0zC-1lbuA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qh5 | PROTEIN(HYDROXYACYLGLUTATHIONE HYDROLASE) (Homo sapiens) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 5 | ASP A 79HIS A 59HIS A 54ASP A 58HIS A 56 | None ZN A 262 ( 3.3A) ZN A 261 ( 3.4A) ZN A 262 (-2.7A) ZN A 261 ( 3.3A) | 1.36A | 3c0zC-1qh5A:undetectable | 3c0zC-1qh5A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwy | PEPTIDOGLYCANHYDROLASE (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 4 | HIS A 291HIS A 260ASP A 214HIS A 293 | NoneNone ZN A 400 (-2.2A) ZN A 400 (-3.1A) | 0.90A | 3c0zC-1qwyA:undetectable | 3c0zC-1qwyA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1taq | TAQ DNA POLYMERASE (Thermusaquaticus) |
PF00476(DNA_pol_A)PF01367(5_3_exonuc)PF02739(5_3_exonuc_N)PF09281(Taq-exonuc) | 4 | ASP A 144HIS A 20HIS A 21ASP A 67 | NoneNone ZN A 900 (-4.5A)None | 1.04A | 3c0zC-1taqA:undetectable | 3c0zC-1taqA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wpn | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Bacillussubtilis) |
PF01368(DHH) | 4 | HIS A 97HIS A 98ASP A 149ASP A 13 | MN A 602 (-3.4A)None MN A 602 (-2.6A) MN A 601 (-2.1A) | 1.10A | 3c0zC-1wpnA:undetectable | 3c0zC-1wpnA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkp | HYPOTHETICAL PROTEINBA1088 (Bacillusanthracis) |
PF12706(Lactamase_B_2) | 5 | ASP A 96HIS A 64HIS A 59ASP A 63HIS A 61 | None ZN A 246 (-3.2A) ZN A 245 (-3.3A) ZN A 246 (-2.7A) ZN A 245 (-3.1A) | 1.42A | 3c0zC-1zkpA:undetectable | 3c0zC-1zkpA:20.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zz3 | HISTONEDEACETYLASE-LIKEAMIDOHYDROLASE (Alcaligenaceaebacterium FB188) |
PF00850(Hist_deacetyl) | 5 | HIS A 142HIS A 143ASP A 180HIS A 182ASP A 268 | 3YP A1452 (-3.3A)3YP A1452 (-3.4A) ZN A1451 (-1.9A) ZN A1451 (-3.3A) ZN A1451 ( 2.5A) | 0.20A | 3c0zC-1zz3A:48.2 | 3c0zC-1zz3A:33.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3l | AMP DEAMINASE (Arabidopsisthaliana) |
PF00962(A_deaminase) | 5 | ASP A 601HIS A 391HIS A 659ASP A 736ASP A 737 | None ZN A 840 ( 3.2A) ZN A 840 ( 3.1A)CF5 A 841 ( 2.5A)CF5 A 841 (-2.5A) | 1.46A | 3c0zC-2a3lA:undetectable | 3c0zC-2a3lA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bq8 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Homo sapiens) |
PF00149(Metallophos) | 4 | ASP X 144HIS X 193HIS X 221ASP X 12 | NoneNoneFE2 X1305 (-3.4A)FE2 X1305 (-3.1A) | 1.13A | 3c0zC-2bq8X:undetectable | 3c0zC-2bq8X:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dqb | DEOXYGUANOSINETRIPHOSPHATETRIPHOSPHOHYDROLASE,PUTATIVE (Thermusthermophilus) |
PF01966(HD)PF13286(HD_assoc) | 4 | HIS A 112HIS A 117ASP A 109ASP A 196 | NoneNone MG A 506 (-2.9A) MG A 506 (-2.4A) | 1.09A | 3c0zC-2dqbA:undetectable | 3c0zC-2dqbA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb0 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01368(DHH)PF02833(DHHA2) | 4 | HIS A 88HIS A 89ASP A 147ASP A 11 | MN A 502 (-3.6A)None MN A 502 (-2.6A) MN A 501 (-2.5A) | 1.06A | 3c0zC-2eb0A:undetectable | 3c0zC-2eb0A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2enx | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusagalactiae) |
PF01368(DHH)PF02833(DHHA2) | 4 | HIS A 99HIS A 100ASP A 151ASP A 13 | MN A 402 ( 3.7A)2PN A1001 (-3.9A) MN A 402 ( 2.7A) MN A 401 (-2.6A) | 1.18A | 3c0zC-2enxA:undetectable | 3c0zC-2enxA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gcu | PUTATIVEHYDROXYACYLGLUTATHIONE HYDROLASE 3 (Arabidopsisthaliana) |
PF00753(Lactamase_B) | 4 | ASP A 164HIS A 72HIS A 128ASP A 76 | NoneFE2 A 300 (-3.3A)FE2 A 300 (-3.4A)None | 0.87A | 3c0zC-2gcuA:undetectable | 3c0zC-2gcuA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gu1 | ZINC PEPTIDASE (Vibrio cholerae) |
PF01551(Peptidase_M23)PF04225(OapA) | 4 | HIS A 311HIS A 280ASP A 236HIS A 313 | NoneNone ZN A 362 (-2.1A) ZN A 362 (-3.1A) | 1.04A | 3c0zC-2gu1A:undetectable | 3c0zC-2gu1A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4g | HYALURONOGLUCOSAMINIDASE (Bacteroidesthetaiotaomicron) |
PF02838(Glyco_hydro_20b)PF07555(NAGidase) | 4 | ASP A 167HIS A 171HIS A 207ASP A 242 | NoneNoneNoneNB1 A1590 (-3.7A) | 0.86A | 3c0zC-2j4gA:undetectable | 3c0zC-2j4gA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jc4 | EXODEOXYRIBONUCLEASEIII (Neisseriameningitidis) |
PF03372(Exo_endo_phos) | 4 | ASP A 202ASP A 217HIS A 247ASP A 146 | None | 1.15A | 3c0zC-2jc4A:undetectable | 3c0zC-2jc4A:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2naf | PEPTIDYL-TRNAHYDROLASE (Mycolicibacteriumsmegmatis) |
PF01195(Pept_tRNA_hydro) | 4 | ASP A 145HIS A 22ASP A 95HIS A 115 | None | 1.15A | 3c0zC-2nafA:3.0 | 3c0zC-2nafA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6i | HD DOMAIN PROTEIN (Enterococcusfaecalis) |
PF01966(HD) | 4 | HIS A 114HIS A 129ASP A 111ASP A 183 | NoneNone ZN A 501 (-2.6A) ZN A 501 (-2.4A) | 1.16A | 3c0zC-2o6iA:undetectable | 3c0zC-2o6iA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q14 | PHOSPHOHYDROLASE (Bacteroidesthetaiotaomicron) |
PF01966(HD) | 4 | HIS A 99HIS A 116ASP A 96ASP A 162 | None | 1.10A | 3c0zC-2q14A:undetectable | 3c0zC-2q14A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q42 | PUTATIVEHYDROXYACYLGLUTATHIONE HYDROLASE 2 (Arabidopsisthaliana) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 5 | ASP A 80HIS A 59HIS A 54ASP A 58HIS A 56 | None FE A 701 (-3.1A) ZN A 700 (-3.2A) FE A 701 (-2.6A) ZN A 700 (-3.2A) | 1.40A | 3c0zC-2q42A:undetectable | 3c0zC-2q42A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2voa | EXODEOXYRIBONUCLEASEIII (Archaeoglobusfulgidus) |
PF03372(Exo_endo_phos) | 4 | ASP A 202ASP A 218HIS A 248ASP A 146 | None | 1.09A | 3c0zC-2voaA:undetectable | 3c0zC-2voaA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9m | POLYMERASE X (Deinococcusradiodurans) |
PF14520(HHH_5)PF14716(HHH_8) | 4 | ASP A 403HIS A 332ASP A 516HIS A 456 | None ZN A1566 (-3.4A) ZN A1566 (-2.5A) ZN A1567 (-3.6A) | 0.92A | 3c0zC-2w9mA:undetectable | 3c0zC-2w9mA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjn | DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE (Saccharopolysporaerythraea) |
PF00067(p450) | 4 | ASP B 60HIS B 270HIS B 266ASP B 233 | None | 1.19A | 3c0zC-2yjnB:undetectable | 3c0zC-2yjnB:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwr | METALLO-BETA-LACTAMASE SUPERFAMILYPROTEIN (Thermusthermophilus) |
PF00753(Lactamase_B) | 4 | ASP A 155HIS A 54HIS A 125ASP A 58 | None ZN A 209 (-3.3A) ZN A 209 (-3.3A) ZN A 208 (-2.7A) | 0.84A | 3c0zC-2zwrA:undetectable | 3c0zC-2zwrA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxo | SINGLE-STRANDED DNASPECIFIC EXONUCLEASERECJ (Thermusthermophilus) |
PF01368(DHH)PF02272(DHHA1) | 4 | HIS A 160HIS A 161ASP A 221ASP A 82 | None | 1.13A | 3c0zC-2zxoA:undetectable | 3c0zC-2zxoA:22.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c10 | HISTONE DEACETYLASE7A (Homo sapiens) |
PF00850(Hist_deacetyl) | 6 | ASP A 626HIS A 669HIS A 670ASP A 707HIS A 709ASP A 801 | TSN A 301 ( 4.0A)TSN A 301 (-3.9A)TSN A 301 (-3.8A) ZN A 101 (-2.1A) ZN A 101 (-3.1A) ZN A 101 ( 2.5A) | 0.23A | 3c0zC-3c10A:66.6 | 3c0zC-3c10A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csq | MORPHOGENESISPROTEIN 1 (Bacillus virusphi29) |
no annotation | 4 | HIS A 278HIS A 247ASP A 195HIS A 280 | NoneNone ZN A 335 (-2.1A) ZN A 335 (-3.1A) | 0.91A | 3c0zC-3csqA:undetectable | 3c0zC-3csqA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAINRESPIRATORY NITRATEREDUCTASE 1 BETACHAINRESPIRATORY NITRATEREDUCTASE 1 GAMMACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF02665(Nitrate_red_gam)PF13247(Fer4_11)PF14710(Nitr_red_alph_N)PF14711(Nitr_red_bet_C) | 4 | ASP B 213HIS C 225ASP B 488ASP A 5 | None | 1.20A | 3c0zC-3egwB:undetectable | 3c0zC-3egwB:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1p | PROTEIN PHNP (Escherichiacoli) |
PF12706(Lactamase_B_2) | 5 | ASP A 103HIS A 81HIS A 76ASP A 80HIS A 78 | None MN A 401 (-3.5A) MN A 400 ( 3.4A)MLT A 500 ( 2.8A) MN A 400 ( 3.3A) | 1.36A | 3c0zC-3g1pA:undetectable | 3c0zC-3g1pA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdc | MULTICOPPER OXIDASE (Arthrobactersp. FB24) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 99HIS A 152HIS A 97ASP A 54 | CU A 301 (-3.1A) CU A 301 (-3.2A)NoneNone | 1.15A | 3c0zC-3gdcA:undetectable | 3c0zC-3gdcA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3io1 | AMINOBENZOYL-GLUTAMATE UTILIZATIONPROTEIN (Klebsiellapneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | HIS A 153HIS A 208ASP A 151HIS A 150 | NoneNone NA A 501 (-2.0A)None | 0.85A | 3c0zC-3io1A:undetectable | 3c0zC-3io1A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3it7 | PROTEASE LASA (Pseudomonasaeruginosa) |
PF01551(Peptidase_M23) | 4 | HIS A 120HIS A 81ASP A 36HIS A 122 | TLA A 300 (-3.9A)TLA A 300 (-4.2A) ZN A 183 ( 2.1A) ZN A 183 ( 3.0A) | 1.04A | 3c0zC-3it7A:undetectable | 3c0zC-3it7A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 4 | ASP A 51HIS A 204ASP A 238ASP A 240 | None FE A 333 (-3.3A) FE A 333 (-1.9A) FE A 333 (-2.5A) | 1.17A | 3c0zC-3ktcA:undetectable | 3c0zC-3ktcA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lat | BIFUNCTIONALAUTOLYSIN (Staphylococcusepidermidis) |
PF01510(Amidase_2) | 4 | ASP A 90HIS A 187HIS A 124ASP A 65 | NoneNone ZN A 221 ( 3.0A) ZN A 220 (-2.3A) | 0.86A | 3c0zC-3latA:undetectable | 3c0zC-3latA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 4 | HIS A 86HIS A 330ASP A 415ASP A 416 | ZN A 512 (-3.4A) ZN A 512 ( 3.5A)CFE A 513 ( 2.8A)CFE A 513 (-2.8A) | 1.21A | 3c0zC-3lggA:undetectable | 3c0zC-3lggA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3max | HISTONE DEACETYLASE2 (Homo sapiens) |
PF00850(Hist_deacetyl) | 6 | ASP A 104HIS A 145HIS A 146ASP A 181HIS A 183ASP A 269 | NoneLLX A 400 (-4.0A)LLX A 400 (-3.8A) ZN A 379 (-2.3A) ZN A 379 (-3.2A) ZN A 379 ( 2.5A) | 0.40A | 3c0zC-3maxA:42.3 | 3c0zC-3maxA:25.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3men | ACETYLPOLYAMINEAMINOHYDROLASE (Burkholderiapseudomallei) |
PF00850(Hist_deacetyl) | 5 | ASP A 113HIS A 156HIS A 157ASP A 192HIS A 194 | NoneSO4 A 401 (-3.6A)SO4 A 401 (-3.4A) ZN A 400 (-2.3A) ZN A 400 (-3.3A) | 1.48A | 3c0zC-3menA:38.8 | 3c0zC-3menA:30.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3men | ACETYLPOLYAMINEAMINOHYDROLASE (Burkholderiapseudomallei) |
PF00850(Hist_deacetyl) | 5 | HIS A 156HIS A 157ASP A 192HIS A 194ASP A 281 | SO4 A 401 (-3.6A)SO4 A 401 (-3.4A) ZN A 400 (-2.3A) ZN A 400 (-3.3A) ZN A 400 ( 2.6A) | 0.22A | 3c0zC-3menA:38.8 | 3c0zC-3menA:30.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyy | PUTATIVEGLYCYL-GLYCINEENDOPEPTIDASE LYTM ([Ruminococcus]gnavus) |
PF01551(Peptidase_M23) | 4 | HIS A 243HIS A 204ASP A 156HIS A 245 | None | 1.02A | 3c0zC-3nyyA:undetectable | 3c0zC-3nyyA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob8 | BETA-GALACTOSIDASE (Kluyveromyceslactis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N) | 4 | HIS A 327HIS A 326ASP A 401HIS A 471 | None | 1.00A | 3c0zC-3ob8A:undetectable | 3c0zC-3ob8A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 4 | HIS A 16HIS A 196ASP A 277ASP A 278 | ZN A 327 (-3.4A) ZN A 327 ( 3.5A) ZN A 327 ( 2.6A)ADE A 328 (-2.8A) | 1.12A | 3c0zC-3paoA:undetectable | 3c0zC-3paoA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9c | ACETYLPOLYAMINEAMIDOHYDROLASE (Mycoplanaramosa) |
PF00850(Hist_deacetyl) | 4 | HIS A 158ASP A 195HIS A 197ASP A 284 | Q9C A 401 (-4.2A) ZN A 343 (-2.3A) ZN A 343 (-3.4A) ZN A 343 (-2.7A) | 0.23A | 3c0zC-3q9cA:39.3 | 3c0zC-3q9cA:25.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 4 | HIS A 19HIS A 199ASP A 280ASP A 281 | ZN A 344 (-3.5A) ZN A 344 ( 3.4A) ZN A 344 ( 2.5A)ADE A 345 (-2.8A) | 1.11A | 3c0zC-3rysA:undetectable | 3c0zC-3rysA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbq | NITROUS-OXIDEREDUCTASE (Pseudomonasstutzeri) |
no annotation | 4 | HIS A 129HIS A 494ASP A 127HIS A 78 | CUK A 702 (-3.5A)CUK A 702 (-3.3A)NoneNone | 1.04A | 3c0zC-3sbqA:undetectable | 3c0zC-3sbqA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slu | M23 PEPTIDASE DOMAINPROTEIN (Neisseriameningitidis) |
PF01551(Peptidase_M23) | 4 | HIS A 373HIS A 343ASP A 299HIS A 375 | NoneNone NI A 1 (-2.5A) NI A 1 (-3.2A) | 1.01A | 3c0zC-3sluA:undetectable | 3c0zC-3sluA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3o | METAL DEPENDENTHYDROLASE (Thermusthermophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 4 | HIS A 150HIS A 376HIS A 398ASP A 79 | NoneNone ZN A 600 (-3.6A) ZN A 600 (-2.5A) | 1.11A | 3c0zC-3t3oA:undetectable | 3c0zC-3t3oA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 4 | HIS A 239HIS A 218ASP A 289ASP A 290 | UNX A 606 ( 3.6A)UNX A 606 ( 3.2A)UNX A 608 ( 2.4A)None | 1.17A | 3c0zC-3t8lA:undetectable | 3c0zC-3t8lA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tp9 | BETA-LACTAMASE ANDRHODANESE DOMAINPROTEIN (Alicyclobacillusacidocaldarius) |
PF00581(Rhodanese)PF00753(Lactamase_B) | 4 | ASP A 157HIS A 56HIS A 120ASP A 60 | None ZN A 472 (-3.3A) ZN A 472 (-3.4A) ZN A 472 ( 4.9A) | 0.79A | 3c0zC-3tp9A:undetectable | 3c0zC-3tp9A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | HIS A 330HIS A 309ASP A 247ASP A 245 | NoneNone ZN A 474 ( 2.5A) ZN A 474 (-2.6A) | 1.15A | 3c0zC-3uw2A:undetectable | 3c0zC-3uw2A:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtr | N-ACETYLGLUCOSAMINIDASE (Ostriniafurnacalis) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 4 | HIS A 246ASP A 299HIS A 303ASP A 367 | NoneNoneTCG A 601 (-4.1A)TCG A 601 (-3.2A) | 1.17A | 3c0zC-3vtrA:undetectable | 3c0zC-3vtrA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdf | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Thermosynechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ASP A 327HIS A 335HIS A 331HIS A 140 | None | 1.18A | 3c0zC-3zdfA:2.3 | 3c0zC-3zdfA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a69 | HISTONE DEACETYLASE3, (Homo sapiens) |
PF00850(Hist_deacetyl) | 6 | ASP A 93HIS A 134HIS A 135ASP A 170HIS A 172ASP A 259 | NoneACT A 501 (-4.0A)ACT A 501 (-3.7A) ZN A 500 (-2.2A) ZN A 500 (-3.1A) ZN A 500 ( 2.4A) | 0.27A | 3c0zC-4a69A:41.4 | 3c0zC-4a69A:24.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkx | HISTONE DEACETYLASE1 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | ASP B 99HIS B 140HIS B 141ASP B 176HIS B 178 | NoneACT B 601 (-3.7A)ACT B 601 (-3.8A) ZN B 600 (-2.2A) ZN B 600 (-3.3A) | 0.84A | 3c0zC-4bkxB:41.5 | 3c0zC-4bkxB:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkx | HISTONE DEACETYLASE1 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS B 140HIS B 141ASP B 176HIS B 178ASP B 264 | ACT B 601 (-3.7A)ACT B 601 (-3.8A) ZN B 600 (-2.2A) ZN B 600 (-3.3A) ZN B 600 ( 2.5A) | 0.30A | 3c0zC-4bkxB:41.5 | 3c0zC-4bkxB:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | HIS A 141HIS A 142ASP A 186HIS A 188ASP A 285 | B3N A 700 (-3.9A)B3N A 700 (-3.7A) ZN A 500 (-2.3A) ZN A 500 (-3.1A) ZN A 500 ( 2.5A) | 0.20A | 3c0zC-4bz7A:38.8 | 3c0zC-4bz7A:25.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4b | SUPEROXIDE REDUCTASE (Archaeoglobusfulgidus) |
PF01880(Desulfoferrodox) | 4 | ASP A 8HIS A 40HIS A 14HIS A 113 | NoneFE2 A1001 (-3.4A)FE2 A1001 (-3.4A)FE2 A1001 (-3.2A) | 1.01A | 3c0zC-4c4bA:undetectable | 3c0zC-4c4bA:14.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4cby | HISTONE DEACETYLASE4 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 802HIS A 803ASP A 840HIS A 842ASP A 934 | KEE A2033 (-3.8A)KEE A2033 (-4.0A) ZN A2034 (-2.0A) ZN A2034 (-3.2A) ZN A2034 ( 2.4A) | 0.19A | 3c0zC-4cbyA:61.6 | 3c0zC-4cbyA:69.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4chl | PERSULFIDEDIOXYGENASE ETHE1,MITOCHONDRIAL (Homo sapiens) |
PF00753(Lactamase_B) | 4 | ASP A 165HIS A 79HIS A 135ASP A 83 | None FE A 501 (-3.5A) FE A 501 (-3.4A)None | 0.87A | 3c0zC-4chlA:undetectable | 3c0zC-4chlA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4efz | METALLO-BETA-LACTAMASE FAMILY PROTEIN (Burkholderiapseudomallei) |
PF00753(Lactamase_B) | 4 | ASP A 183HIS A 68HIS A 143ASP A 72 | None CA A 301 (-3.5A) CA A 301 (-3.6A) CA A 301 ( 4.9A) | 0.85A | 3c0zC-4efzA:undetectable | 3c0zC-4efzA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzi | PROSTAGLANDIN FSYNTHASE (Trypanosomacruzi) |
PF00248(Aldo_ket_red) | 4 | HIS A 145HIS A 146ASP A 274ASP A 272 | None | 1.15A | 3c0zC-4fziA:undetectable | 3c0zC-4fziA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxw | ADENOSINE DEAMINASE (Burkholderiaambifaria) |
PF00962(A_deaminase) | 4 | HIS A 34HIS A 215ASP A 300ASP A 301 | ZN A 401 (-3.4A) ZN A 401 (-3.4A) ZN A 401 (-2.6A)None | 1.16A | 3c0zC-4gxwA:undetectable | 3c0zC-4gxwA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia5 | MYOSIN-CROSSREACTIVEANTIGEN (Lactobacillusacidophilus) |
PF06100(MCRA) | 4 | ASP A 539HIS A 207HIS A 206HIS A 86 | NoneMPD A 604 ( 4.9A)NoneNone | 1.12A | 3c0zC-4ia5A:undetectable | 3c0zC-4ia5A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4knk | BIFUNCTIONALAUTOLYSIN (Staphylococcusaureus) |
PF01510(Amidase_2) | 4 | ASP A 295HIS A 392HIS A 329ASP A 270 | None | 0.86A | 3c0zC-4knkA:undetectable | 3c0zC-4knkA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpb | LYSOSTAPHIN (Staphylococcussimulans) |
PF01551(Peptidase_M23) | 4 | HIS A 360HIS A 329ASP A 283HIS A 362 | NoneNone ZN A 401 (-2.3A) ZN A 401 (-3.1A) | 0.92A | 3c0zC-4qpbA:undetectable | 3c0zC-4qpbA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnz | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF01551(Peptidase_M23) | 4 | HIS A 339HIS A 306ASP A 263HIS A 341 | NoneNone ZN A 501 (-2.1A) ZN A 501 (-3.1A) | 1.02A | 3c0zC-4rnzA:undetectable | 3c0zC-4rnzA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rpa | PROBABLEMANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Staphylococcusaureus) |
PF01368(DHH)PF02833(DHHA2) | 4 | HIS A 97HIS A 98ASP A 149ASP A 13 | MN A 500 (-3.2A) MN A 500 (-4.7A) MN A 500 (-2.6A) MN A 501 (-2.0A) | 1.01A | 3c0zC-4rpaA:undetectable | 3c0zC-4rpaA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysb | METALLO-BETA-LACTAMASE FAMILY PROTEIN (Myxococcusxanthus) |
PF00753(Lactamase_B) | 4 | ASP A 140HIS A 57HIS A 112ASP A 61 | None FE A 301 (-3.4A) FE A 301 (-3.3A)None | 0.86A | 3c0zC-4ysbA:undetectable | 3c0zC-4ysbA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysl | BETA-LACTAMASEDOMAIN PROTEIN (Pseudomonasputida) |
PF00753(Lactamase_B) | 4 | ASP A 183HIS A 74HIS A 149ASP A 78 | None FE A 301 (-3.4A) FE A 301 ( 3.5A)GSH A 302 ( 4.4A) | 0.85A | 3c0zC-4yslA:undetectable | 3c0zC-4yslA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zwe | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Homo sapiens) |
PF01966(HD) | 4 | ASP A 311HIS A 210ASP A 218HIS A 215 | DGT A 701 (-2.4A)DGT A 701 (-4.5A)NoneDGT A 701 (-3.6A) | 1.05A | 3c0zC-4zweA:undetectable | 3c0zC-4zweA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ao0 | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Homo sapiens) |
PF01966(HD) | 4 | HIS A 210HIS A 215ASP A 207ASP A 311 | DG3 A2001 (-4.6A)DG3 A2001 (-3.4A) FE A1001 ( 2.7A) FE A1001 ( 2.6A) | 1.17A | 3c0zC-5ao0A:undetectable | 3c0zC-5ao0A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b4c | UDP-2,3-DIACYLGLUCOSAMINE HYDROLASE (Pseudomonasaeruginosa) |
PF00149(Metallophos) | 4 | ASP A 122HIS A 114HIS A 195ASP A 41 | GOL A 302 (-3.9A) MN A 301 (-3.5A) MN A 301 ( 3.4A) MN A 301 (-2.6A) | 1.12A | 3c0zC-5b4cA:undetectable | 3c0zC-5b4cA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 5 | ASP B 567HIS B 610HIS B 611ASP B 649HIS B 651 | NoneTSN B2501 (-3.8A)TSN B2501 (-3.9A) ZN B2502 (-2.2A) ZN B2502 (-3.2A) | 1.33A | 3c0zC-5eduB:54.8 | 3c0zC-5eduB:28.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 5 | HIS B 610HIS B 611ASP B 649HIS B 651ASP B 742 | TSN B2501 (-3.8A)TSN B2501 (-3.9A) ZN B2502 (-2.2A) ZN B2502 (-3.2A) ZN B2502 ( 2.7A) | 0.26A | 3c0zC-5eduB:54.8 | 3c0zC-5eduB:28.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | ASP A 149HIS A 192HIS A 193ASP A 230HIS A 232 | NoneTSN A2002 (-3.9A)TSN A2002 (-3.9A) ZN A2001 (-2.3A) ZN A2001 (-3.1A) | 1.31A | 3c0zC-5eefA:54.0 | 3c0zC-5eefA:35.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 192HIS A 193ASP A 230HIS A 232ASP A 323 | TSN A2002 (-3.9A)TSN A2002 (-3.9A) ZN A2001 (-2.3A) ZN A2001 (-3.1A) ZN A2001 ( 2.7A) | 0.27A | 3c0zC-5eefA:54.0 | 3c0zC-5eefA:35.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5efn | HDAC6 PROTEIN (Danio rerio) |
no annotation | 4 | HIS B 573ASP B 612HIS B 614ASP B 705 | None ZN B 801 ( 2.1A) ZN B 801 ( 3.2A) ZN B 801 (-2.6A) | 0.15A | 3c0zC-5efnB:56.0 | 3c0zC-5efnB:41.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | HIS A 573HIS A 574ASP A 612HIS A 614ASP A 705 | E1Z A1801 (-3.9A)E1Z A1801 (-3.8A) ZN A1804 (-2.1A) ZN A1804 (-3.2A) ZN A1804 ( 2.5A) | 0.16A | 3c0zC-5g0hA:56.2 | 3c0zC-5g0hA:27.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5g10 | HDAH (Pseudomonasaeruginosa) |
PF00850(Hist_deacetyl) | 6 | ASP A 101HIS A 143HIS A 144ASP A 181HIS A 183ASP A 269 | 6DK A1375 (-3.0A)6DK A1375 (-4.1A)6DK A1375 (-3.9A) ZN A1372 (-2.0A) ZN A1372 (-3.2A) ZN A1372 ( 2.5A) | 0.69A | 3c0zC-5g10A:47.0 | 3c0zC-5g10A:31.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1l | TOXR-ACTIVATED GENE(TAGE) (Helicobacterpylori) |
PF01551(Peptidase_M23) | 4 | HIS A 250HIS A 219ASP A 173HIS A 252 | ZN A 401 (-4.1A) ZN A 401 (-4.4A) ZN A 401 (-2.6A) ZN A 401 (-4.0A) | 0.94A | 3c0zC-5j1lA:undetectable | 3c0zC-5j1lA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ji5 | BUPHA.10154.A.B1 (Paraburkholderiaphymatum) |
PF00850(Hist_deacetyl) | 6 | ASP A 83HIS A 125HIS A 126ASP A 163HIS A 165ASP A 244 | EDO A 403 ( 4.6A)NoneEDO A 403 (-4.2A) ZN A 401 ( 2.2A) ZN A 401 (-3.1A) ZN A 401 (-2.5A) | 0.61A | 3c0zC-5ji5A:44.6 | 3c0zC-5ji5A:29.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jju | UNCHARACTERIZEDPROTEIN RV2837C (Mycobacteriumtuberculosis) |
PF01368(DHH)PF02272(DHHA1) | 4 | HIS A 132HIS A 312ASP A 106ASP A 45 | A C1004 ( 3.5A) A C1004 ( 3.7A) MN A1001 ( 2.6A) MN A1002 (-2.2A) | 1.09A | 3c0zC-5jjuA:undetectable | 3c0zC-5jjuA:25.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jju | UNCHARACTERIZEDPROTEIN RV2837C (Mycobacteriumtuberculosis) |
PF01368(DHH)PF02272(DHHA1) | 4 | HIS A 132HIS A 312ASP A 106ASP A 47 | A C1004 ( 3.5A) A C1004 ( 3.7A) MN A1001 ( 2.6A) MN A1001 (-3.2A) | 1.15A | 3c0zC-5jjuA:undetectable | 3c0zC-5jjuA:25.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8b | 8-AMINO-3,8-DIDEOXY-ALPHA-D-MANNO-OCTULOSONATE TRANSAMINASE (Shewanellaoneidensis) |
PF01041(DegT_DnrJ_EryC1) | 4 | ASP A 221HIS A 217ASP A 212HIS A 215 | None | 0.83A | 3c0zC-5k8bA:undetectable | 3c0zC-5k8bA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqc | PEPTIDASE M23 (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 4 | HIS A 157HIS A 125ASP A 80HIS A 159 | NoneNone ZN A 201 (-1.5A) ZN A 201 (-3.2A) | 1.03A | 3c0zC-5kqcA:undetectable | 3c0zC-5kqcA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kvp | ZOOCIN AENDOPEPTIDASE (Streptococcusequi) |
PF01551(Peptidase_M23) | 4 | HIS A 120HIS A 89ASP A 38HIS A 122 | NoneUNL A 202 ( 3.8A) ZN A 201 (-1.9A) ZN A 201 (-3.1A) | 1.17A | 3c0zC-5kvpA:undetectable | 3c0zC-5kvpA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 4 | ASP A 172HIS A 545HIS A 540ASP A 544 | None ZN A 902 (-3.4A) ZN A 901 (-3.4A) ZN A 902 ( 2.6A) | 1.17A | 3c0zC-5mtzA:undetectable | 3c0zC-5mtzA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o25 | TMPDE (Thermotogamaritima) |
no annotation | 4 | HIS A 104HIS A 105ASP A 154ASP A 23 | MN A 402 (-3.5A)PG4 A 403 (-4.5A) MN A 402 (-2.8A) MN A 401 (-2.0A) | 1.19A | 3c0zC-5o25A:undetectable | 3c0zC-5o25A:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oar | BETA-HEXOSAMINIDASE (Aspergillusoryzae) |
no annotation | 4 | HIS B 219ASP B 271HIS B 275ASP B 345 | NoneNoneNGT B 707 (-4.0A)NGT B 707 (-3.9A) | 1.21A | 3c0zC-5oarB:undetectable | 3c0zC-5oarB:13.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td7 | ZGC:55652 (Danio rerio) |
PF00850(Hist_deacetyl) | 6 | ASP A 94HIS A 136HIS A 137ASP A 174HIS A 176ASP A 267 | FKS A 711 (-3.5A)FKS A 711 (-4.0A)FKS A 711 (-3.5A) ZN A 701 (-1.9A) ZN A 701 (-3.3A) ZN A 701 ( 2.6A) | 0.70A | 3c0zC-5td7A:53.8 | 3c0zC-5td7A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve3 | BPPRF (Paraburkholderiaphytofirmans) |
no annotation | 4 | ASP B 144HIS B 58HIS B 114ASP B 62 | None FE B 500 (-3.3A) FE B 500 (-3.3A)None | 0.81A | 3c0zC-5ve3B:undetectable | 3c0zC-5ve3B:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vi6 | HISTONE DEACETYLASE8 (Homo sapiens) |
PF00850(Hist_deacetyl) | 6 | ASP A 101HIS A 142HIS A 143ASP A 178HIS A 180ASP A 267 | NoneNoneEDO A 410 (-4.4A) ZN A 401 ( 2.3A) ZN A 401 ( 3.1A) ZN A 401 (-2.4A) | 0.36A | 3c0zC-5vi6A:39.9 | 3c0zC-5vi6A:25.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yh1 | - (-) |
no annotation | 4 | HIS A 462HIS A 463ASP A 528ASP A 364 | MN A 805 (-3.6A)None MN A 805 (-2.6A) MN A 805 ( 4.7A) | 1.18A | 3c0zC-5yh1A:undetectable | 3c0zC-5yh1A:undetectable |