SIMILAR PATTERNS OF AMINO ACIDS FOR 3BXO_A_SAMA238_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 TYR A  87
GLU A 136
ASP A 139
 None
 0.86A 3bxoA-1ikpA:
undetectable		 3bxoA-1ikpA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 TYR A   7
GLU A  10
ASP A  54
 GOL  A2002 (-3.5A)
None
None
 0.78A 3bxoA-1iyxA:
undetectable		 3bxoA-1iyxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		3 TYR A 251
GLU A 247
ASP A 208
 None
 0.67A 3bxoA-1j0aA:
2.5		 3bxoA-1j0aA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR B 872
GLU B 543
ASP B 591
 None
 0.83A 3bxoA-1m2vB:
undetectable		 3bxoA-1m2vB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 3 TYR A 341
GLU A 138
ASP A 151
 None
 0.86A 3bxoA-1nluA:
undetectable		 3bxoA-1nluA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR A 872
GLU A 543
ASP A 591
 None
 0.77A 3bxoA-1pd1A:
undetectable		 3bxoA-1pd1A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		3 TYR A 180
GLU A 237
ASP A 482
 None
I40  A 997 (-4.2A)
None
 0.68A 3bxoA-1qonA:
undetectable		 3bxoA-1qonA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		3 TYR A 171
GLU A 213
ASP A 240
 ACT  A 421 ( 4.2A)
SAM  A 635 (-2.9A)
SAM  A 635 (-3.7A)
 0.49A 3bxoA-1qzzA:
17.0		 3bxoA-1qzzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		3 TYR A 237
GLU A 145
ASP A 111
 GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 0.83A 3bxoA-1s1dA:
undetectable		 3bxoA-1s1dA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 TYR B 108
GLU B  66
ASP B 273
 None
 0.85A 3bxoA-1sr4B:
undetectable		 3bxoA-1sr4B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 TYR A1877
GLU A1888
ASP A1965
 None
 0.59A 3bxoA-1u4qA:
undetectable		 3bxoA-1u4qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		3 TYR A 326
GLU A 431
ASP A 510
 ACR  A3000 (-3.9A)
ACR  A3000 (-3.5A)
None
 0.74A 3bxoA-1ulvA:
2.4		 3bxoA-1ulvA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 TYR A 448
GLU A 459
ASP A 462
 None
 0.73A 3bxoA-1zy9A:
undetectable		 3bxoA-1zy9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 670
GLU A 205
ASP A 739
 None
008  A1767 (-3.9A)
None
 0.72A 3bxoA-2bucA:
undetectable		 3bxoA-2bucA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		3 TYR A  37
GLU A  41
ASP A  81
 TYR  A 701 (-4.6A)
TYR  A 701 ( 4.3A)
None
 0.87A 3bxoA-2cycA:
2.6		 3bxoA-2cycA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f42 STIP1 HOMOLOGY AND
U-BOX CONTAINING
PROTEIN 1

(Danio rerio) 		PF04564
(U-box) 		3 TYR A 149
GLU A 157
ASP A 164
 None
 0.61A 3bxoA-2f42A:
undetectable		 3bxoA-2f42A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 670
GLU A 205
ASP A 739
 None
ACF  A 800 (-3.6A)
None
 0.74A 3bxoA-2g5tA:
undetectable		 3bxoA-2g5tA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		3 TYR A 169
GLU A 141
ASP A 193
 None
 0.80A 3bxoA-2j04A:
undetectable		 3bxoA-2j04A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TYR A 315
GLU A 330
ASP A 400
 None
 0.66A 3bxoA-2j5cA:
undetectable		 3bxoA-2j5cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 TYR A 241
GLU A 309
ASP A 322
 None
 0.68A 3bxoA-2nx9A:
undetectable		 3bxoA-2nx9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		3 TYR A 207
GLU A 286
ASP A 288
 None
 0.84A 3bxoA-2o4vA:
undetectable		 3bxoA-2o4vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		3 TYR A1272
GLU A1409
ASP A1375
 None
 0.84A 3bxoA-2ri8A:
undetectable		 3bxoA-2ri8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		3 TYR A  29
GLU A 292
ASP A 387
 None
 0.81A 3bxoA-2rjbA:
undetectable		 3bxoA-2rjbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		3 TYR A 229
GLU A 187
ASP A  68
 None
ADA  A1431 (-3.2A)
None
 0.65A 3bxoA-2uvjA:
undetectable		 3bxoA-2uvjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 TYR A 614
GLU A 493
ASP A 498
 None
 0.77A 3bxoA-2wanA:
undetectable		 3bxoA-2wanA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		3 TYR A1104
GLU A1301
ASP A1364
 None
 0.77A 3bxoA-2wqsA:
undetectable		 3bxoA-2wqsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 TYR A 152
GLU A 147
ASP A 102
 None
GLC  A1418 (-2.9A)
GLC  A1419 (-2.8A)
 0.81A 3bxoA-2xd3A:
undetectable		 3bxoA-2xd3A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		3 TYR A 792
GLU A 586
ASP A1041
 None
 0.85A 3bxoA-2ya1A:
undetectable		 3bxoA-2ya1A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 TYR A 337
GLU A 131
ASP A 586
 None
 0.81A 3bxoA-2ya2A:
undetectable		 3bxoA-2ya2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
LYMPHOCYTE ANTIGEN
96

(Eptatretus
burgeri;
Homo sapiens;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8)
PF02221
(E1_DerP2_DerF2) 		3 TYR C  36
GLU A  42
ASP A  60
 None
 0.80A 3bxoA-2z65C:
undetectable		 3bxoA-2z65C:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 TYR A 433
GLU A  63
ASP A 449
 None
 0.74A 3bxoA-2zxhA:
undetectable		 3bxoA-2zxhA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		3 TYR A  21
GLU A  67
ASP A  89
 SAM  A 238 (-4.9A)
SAM  A 238 (-2.7A)
SAM  A 238 (-3.0A)
 0.00A 3bxoA-3bxoA:
43.9		 3bxoA-3bxoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		3 TYR C 414
GLU C 109
ASP C  14
 None
 0.77A 3bxoA-3degC:
undetectable		 3bxoA-3degC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		3 TYR A 381
GLU A 308
ASP A 294
 None
TPP  A 551 ( 4.9A)
None
 0.77A 3bxoA-3e79A:
undetectable		 3bxoA-3e79A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		3 TYR A 297
GLU A 241
ASP A 178
 None
HAH  A1000 (-3.0A)
None
 0.80A 3bxoA-3emqA:
undetectable		 3bxoA-3emqA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 TYR A 714
GLU A 702
ASP A 617
 None
 0.79A 3bxoA-3gitA:
undetectable		 3bxoA-3gitA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		3 TYR A  54
GLU A  62
ASP A  67
 None
 0.85A 3bxoA-3hlzA:
undetectable		 3bxoA-3hlzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		3 TYR A  66
GLU A 263
ASP A 244
 None
 0.81A 3bxoA-3ipwA:
undetectable		 3bxoA-3ipwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S27,
MITOCHONDRIAL

(Bos taurus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		3 TYR e 184
GLU e 200
ASP e 195
 None
 0.81A 3bxoA-3jd5e:
undetectable		 3bxoA-3jd5e:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 TYR A1170
GLU A1220
ASP A1467
 None
WW2  A 193 ( 4.2A)
None
 0.77A 3bxoA-3k9bA:
undetectable		 3bxoA-3k9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 TYR A1170
GLU A1220
ASP A1470
 None
WW2  A 193 ( 4.2A)
None
 0.79A 3bxoA-3k9bA:
undetectable		 3bxoA-3k9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 TYR A 358
GLU A 221
ASP A 216
 CL  A 496 ( 4.3A)
None
None
 0.78A 3bxoA-3kzwA:
undetectable		 3bxoA-3kzwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		3 TYR A   5
GLU A 375
ASP A 368
 None
 0.85A 3bxoA-3m7dA:
undetectable		 3bxoA-3m7dA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 3 TYR A  87
GLU A 113
ASP A 186
 None
 0.86A 3bxoA-3orjA:
undetectable		 3bxoA-3orjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 TYR A  51
GLU A  40
ASP A  30
 None
 0.81A 3bxoA-3pqsA:
undetectable		 3bxoA-3pqsA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		3 TYR A  33
GLU A  79
ASP A 101
 SAH  A 263 (-4.6A)
SAH  A 263 (-2.7A)
SAH  A 263 (-3.5A)
 0.24A 3bxoA-3px2A:
37.0		 3bxoA-3px2A:
59.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 168
GLU A  24
ASP A  68
 None
 0.86A 3bxoA-3qomA:
undetectable		 3bxoA-3qomA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 TYR A 600
GLU A 562
ASP A 555
 None
 0.81A 3bxoA-3snhA:
undetectable		 3bxoA-3snhA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4t TPR
REPEAT-CONTAINING
PROTEIN

(Cytophaga
hutchinsonii) 		PF07719
(TPR_2) 		3 TYR A 244
GLU A 303
ASP A 329
 None
 0.77A 3bxoA-3u4tA:
undetectable		 3bxoA-3u4tA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 TYR A  84
GLU A 326
ASP A 408
 None
 0.60A 3bxoA-3uw2A:
undetectable		 3bxoA-3uw2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		3 TYR A  68
GLU A 253
ASP A 205
 None
 0.85A 3bxoA-3we7A:
3.3		 3bxoA-3we7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		3 TYR A  64
GLU A 248
ASP A 200
 None
 0.83A 3bxoA-3wl4A:
3.4		 3bxoA-3wl4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 TYR A 387
GLU A 348
ASP A 362
 None
 0.82A 3bxoA-3zk4A:
undetectable		 3bxoA-3zk4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 TYR E 235
GLU E 225
ASP E 266
 None
 0.86A 3bxoA-4a0lE:
undetectable		 3bxoA-4a0lE:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 TYR A   8
GLU A  11
ASP A  55
 None
 0.74A 3bxoA-4a3rA:
undetectable		 3bxoA-4a3rA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		3 TYR A 586
GLU A 528
ASP A 206
 None
 0.80A 3bxoA-4c90A:
undetectable		 3bxoA-4c90A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		3 TYR W1001
GLU W 922
ASP W 984
 None
 0.81A 3bxoA-4f5xW:
undetectable		 3bxoA-4f5xW:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		3 TYR A 165
GLU A 217
ASP A 473
 None
DPF  A 601 ( 4.2A)
None
 0.77A 3bxoA-4fnmA:
undetectable		 3bxoA-4fnmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE

(Streptococcus
mutans) 		PF00232
(Glyco_hydro_1) 		3 TYR A 164
GLU A  20
ASP A  64
 None
 0.84A 3bxoA-4gpnA:
undetectable		 3bxoA-4gpnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.73A 3bxoA-4gqbA:
8.6		 3bxoA-4gqbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 TYR A 473
GLU A 302
ASP A 309
 None
 0.80A 3bxoA-4jeuA:
3.7		 3bxoA-4jeuA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		3 TYR A 140
GLU A 136
ASP A 658
 None
 0.81A 3bxoA-4k0eA:
undetectable		 3bxoA-4k0eA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk5 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Candidatus
Liberibacter
asiaticus) 		PF13561
(adh_short_C2) 		3 TYR A 177
GLU A 126
ASP A  68
 None
 0.66A 3bxoA-4nk5A:
5.8		 3bxoA-4nk5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		3 TYR Y  51
GLU Y 136
ASP Y 181
 None
 0.79A 3bxoA-4ox9Y:
10.6		 3bxoA-4ox9Y:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 TYR A 495
GLU A 818
ASP A 810
 None
 0.82A 3bxoA-4pj6A:
undetectable		 3bxoA-4pj6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		3 TYR A   7
GLU A 266
ASP A  26
 None
 0.85A 3bxoA-4pspA:
undetectable		 3bxoA-4pspA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqu ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TYR A 338
GLU A 237
ASP A 233
 None
 0.86A 3bxoA-4rquA:
6.8		 3bxoA-4rquA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urn DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		3 TYR A 223
GLU A 219
ASP A 210
 None
 0.78A 3bxoA-4urnA:
undetectable		 3bxoA-4urnA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 TYR A   8
GLU A  11
ASP A  55
 None
 0.85A 3bxoA-5boeA:
undetectable		 3bxoA-5boeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 TYR A 495
GLU A 786
ASP A 779
 None
 0.78A 3bxoA-5c2vA:
undetectable		 3bxoA-5c2vA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 TYR A 439
GLU A 485
ASP A 479
 0GA  A 604 ( 4.4A)
None
None
 0.84A 3bxoA-5cwaA:
undetectable		 3bxoA-5cwaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 TYR A 153
GLU A 203
ASP A 448
 None
 0.85A 3bxoA-5fv4A:
undetectable		 3bxoA-5fv4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gol CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		no annotation 3 TYR A 121
GLU A 109
ASP A  24
 None
 0.73A 3bxoA-5golA:
undetectable		 3bxoA-5golA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		3 TYR A1182
GLU A1386
ASP A1015
 None
 0.85A 3bxoA-5jbeA:
2.3		 3bxoA-5jbeA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 TYR A 102
GLU A 342
ASP A 422
 None
G16  A 501 (-2.8A)
None
 0.78A 3bxoA-5kl0A:
undetectable		 3bxoA-5kl0A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 TYR B 365
GLU B 447
ASP B 495
 None
 0.79A 3bxoA-5kohB:
undetectable		 3bxoA-5kohB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		3 TYR A 557
GLU A 561
ASP A 564
 None
 0.84A 3bxoA-5kovA:
undetectable		 3bxoA-5kovA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 3 TYR A 800
GLU A 808
ASP A 856
 None
 0.83A 3bxoA-5lewA:
2.0		 3bxoA-5lewA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		3 TYR B 336
GLU B  34
ASP B 213
 None
None
EDO  B 616 ( 2.8A)
 0.64A 3bxoA-5m99B:
undetectable		 3bxoA-5m99B:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 3 TYR C 386
GLU C 309
ASP C 321
 None
 0.73A 3bxoA-5mg5C:
undetectable		 3bxoA-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		3 TYR N 857
GLU N 669
ASP N 310
 None
 0.78A 3bxoA-5mpdN:
undetectable		 3bxoA-5mpdN:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN5
26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF01399
(PCI) 		3 TYR Q 255
GLU Q 289
ASP P 154
 None
 0.63A 3bxoA-5mpdQ:
undetectable		 3bxoA-5mpdQ:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 3 TYR A 510
GLU A 224
ASP A 723
 None
 0.83A 3bxoA-5mz9A:
2.0		 3bxoA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 3 TYR A 853
GLU A1064
ASP A 677
 None
 0.85A 3bxoA-5ngyA:
undetectable		 3bxoA-5ngyA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 TYR B 638
GLU B 323
ASP B 374
 None
 0.78A 3bxoA-5swiB:
2.6		 3bxoA-5swiB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 TYR A1231
GLU A1200
ASP A1350
 None
 0.79A 3bxoA-5t03A:
undetectable		 3bxoA-5t03A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 TYR A1161
GLU A1011
ASP A1020
 None
 0.86A 3bxoA-5t1aA:
undetectable		 3bxoA-5t1aA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 TYR A 148
GLU A 143
ASP A  99
 None
MAL  A 501 ( 4.2A)
MAL  A 501 (-3.8A)
 0.86A 3bxoA-5tu0A:
undetectable		 3bxoA-5tu0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		3 TYR A 198
GLU A 552
ASP A 597
 None
 0.64A 3bxoA-5v7vA:
undetectable		 3bxoA-5v7vA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		3 TYR A 507
GLU A 552
ASP A 597
 None
 0.75A 3bxoA-5v7vA:
undetectable		 3bxoA-5v7vA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 3 TYR A 933
GLU A 492
ASP A 602
 None
 0.63A 3bxoA-5wlhA:
undetectable		 3bxoA-5wlhA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 3 TYR A 133
GLU A 179
ASP A 304
 None
 0.70A 3bxoA-5xstA:
undetectable		 3bxoA-5xstA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 TYR d  57
GLU e 123
ASP d 102
 None
 0.76A 3bxoA-5xtcd:
undetectable		 3bxoA-5xtcd:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 3 TYR A 309
GLU A 359
ASP A 602
 None
SEB  A 360 ( 3.3A)
None
 0.83A 3bxoA-5ydjA:
undetectable		 3bxoA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 3 TYR A 181
GLU A 229
ASP A 295
 None
SAM  A 505 (-2.9A)
SAM  A 505 (-3.6A)
 0.87A 3bxoA-5yf0A:
14.6		 3bxoA-5yf0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc2 -

(-) 		no annotation 3 TYR B 269
GLU B 251
ASP B  15
 None
 0.86A 3bxoA-5zc2B:
undetectable		 3bxoA-5zc2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
MONOBODY YSX1

(Escherichia
coli;
Homo sapiens;
synthetic
construct) 		no annotation
no annotation 		3 TYR B  77
GLU A  44
ASP A  41
 None
 0.86A 3bxoA-6apxB:
undetectable		 3bxoA-6apxB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 3 TYR A 309
GLU A 359
ASP A 602
 None
 0.82A 3bxoA-6arxA:
undetectable		 3bxoA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 3 TYR A 794
GLU A 840
ASP A 965
 None
 0.77A 3bxoA-6bhvA:
undetectable		 3bxoA-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca;
Thermobifida
fusca) 		no annotation
no annotation 		3 TYR B 232
GLU B 301
ASP M  64
 None
 0.82A 3bxoA-6c66B:
undetectable		 3bxoA-6c66B:
undetectable