SIMILAR PATTERNS OF AMINO ACIDS FOR 3BUF_A_AEGA394_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2o | CHEB METHYLESTERASE (Salmonellaenterica) |
PF00072(Response_reg)PF01339(CheB_methylest) | 4 | ASP A 216ILE A 186ILE A 247GLY A 217 | None | 0.93A | 3bufA-1a2oA:undetectable | 3bufA-1a2oA:24.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1apy | ASPARTYLGLUCOSAMINIDASE (Homo sapiens) |
PF01112(Asparaginase_2) | 4 | LEU B 240ILE B 267ILE B 239GLY B 235 | None | 0.86A | 3bufA-1apyB:undetectable | 3bufA-1apyB:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1chd | CHEB METHYLESTERASE (Salmonellaenterica) |
PF01339(CheB_methylest) | 4 | ASP A 216ILE A 186ILE A 247GLY A 217 | None | 0.93A | 3bufA-1chdA:undetectable | 3bufA-1chdA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czi | CHYMOSIN (Bos taurus) |
PF00026(Asp) | 4 | LEU E 30ASP E 32ILE E 120GLY E 217 | None | 0.46A | 3bufA-1cziE:10.8 | 3bufA-1cziE:28.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f51 | SPORULATIONINITIATIONPHOSPHOTRANSFERASE F (Bacillussubtilis) |
PF00072(Response_reg) | 4 | LEU E1253ILE E1276ILE E1280GLY E1262 | None | 0.85A | 3bufA-1f51E:undetectable | 3bufA-1f51E:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtk | PORPHOBILINOGENDEAMINASE (Escherichiacoli) |
PF01379(Porphobil_deam)PF03900(Porphobil_deamC) | 4 | LEU A 294ILE A 246ILE A 272GLY A 274 | None | 0.95A | 3bufA-1gtkA:undetectable | 3bufA-1gtkA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htr | GASTRICSIN (Homo sapiens) |
PF00026(Asp) | 4 | LEU B 30ASP B 32ILE B 120GLY B 219 | None | 0.67A | 3bufA-1htrB:9.3 | 3bufA-1htrB:26.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25ILE A 84GLY A 27 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.6A)A79 A 800 (-3.0A) | 0.66A | 3bufA-1hvcA:9.0 | 3bufA-1hvcA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25ILE A 84GLY A 27 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.8A)A79 A 800 (-3.0A) | 0.72A | 3bufA-1hvcA:9.0 | 3bufA-1hvcA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3l | DEMETHYLMENAQUINONEMETHYLTRANSFERASE (Thermusthermophilus) |
PF03737(RraA-like) | 4 | LEU A 101ASP A 97ILE A 106GLY A 74 | NoneNoneNone CL A1002 (-3.1A) | 0.84A | 3bufA-1j3lA:undetectable | 3bufA-1j3lA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqe | HISTAMINEN-METHYLTRANSFERASE (Homo sapiens) |
PF13489(Methyltransf_23) | 4 | LEU A 71ASP A 67ILE A 54ILE A 70 | None | 0.97A | 3bufA-1jqeA:undetectable | 3bufA-1jqeA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpp | PEPSIN (Rhizomucorpusillus) |
PF00026(Asp) | 4 | LEU A 30ASP A 32ILE A 120GLY A 217 | None | 0.40A | 3bufA-1mppA:34.5 | 3bufA-1mppA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pe9 | PECTATE LYASE A (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 4 | ASP A 108ILE A 189ILE A 106GLY A 109 | None | 0.95A | 3bufA-1pe9A:undetectable | 3bufA-1pe9A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs8 | PLASMEPSIN (Plasmodiumvivax) |
PF00026(Asp) | 4 | ASP A 34ILE A 114ILE A 123GLY A 216 | None | 0.68A | 3bufA-1qs8A:31.2 | 3bufA-1qs8A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkr | POLYPOROPEPSIN (Irpex lacteus) |
PF00026(Asp) | 4 | LEU A 30ASP A 32ILE A 104GLY A 214 | None | 0.44A | 3bufA-1wkrA:30.9 | 3bufA-1wkrA:27.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z05 | TRANSCRIPTIONALREGULATOR, ROKFAMILY (Vibrio cholerae) |
PF00480(ROK) | 4 | LEU A 243ILE A 325ILE A 246GLY A 241 | None | 0.85A | 3bufA-1z05A:undetectable | 3bufA-1z05A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zap | SECRETED ASPARTICPROTEINASE (Candidaalbicans) |
PF00026(Asp) | 4 | LEU A 216ASP A 218ILE A 305GLY A 34 | NoneA70 A 500 ( 2.3A)A70 A 500 (-4.8A)A70 A 500 (-3.8A) | 0.46A | 3bufA-1zapA:31.9 | 3bufA-1zapA:26.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a08 | HYPOTHETICAL 41.8KDA PROTEIN INSPO13-ARG4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00018(SH3_1) | 4 | ASP A 21ILE A 30ILE A 53GLY A 16 | None | 0.86A | 3bufA-2a08A:undetectable | 3bufA-2a08A:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ay9 | AROMATIC AMINO ACIDAMINOTRANSFERASE (Paracoccusdenitrificans) |
PF00155(Aminotran_1_2) | 4 | LEU A 35ILE A 399ILE A 387GLY A 391 | None | 0.94A | 3bufA-2ay9A:undetectable | 3bufA-2ay9A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9b | FUSION GLYCOPROTEINF0 (Mammalianrubulavirus 5) |
PF00523(Fusion_gly) | 4 | LEU A 224ILE A 206ILE A 221GLY A 257 | None | 0.95A | 3bufA-2b9bA:undetectable | 3bufA-2b9bA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5l | DIPEPTIDYLAMINOPEPTIDASE IV,PUTATIVE (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | LEU A 614ASP A 665ILE A 630GLY A 664 | None | 0.85A | 3bufA-2d5lA:undetectable | 3bufA-2d5lA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dgj | HYPOTHETICAL PROTEINEBHA (Staphylococcusaureus) |
PF01468(GA) | 4 | ASP A 126ILE A 169ILE A 94GLY A 127 | None | 0.97A | 3bufA-2dgjA:undetectable | 3bufA-2dgjA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 4 | LEU A 126ASP A 131ILE A 34GLY A 136 | None | 0.89A | 3bufA-2e3zA:undetectable | 3bufA-2e3zA:23.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ewy | BETA-SECRETASE 2 (Homo sapiens) |
PF00026(Asp) | 4 | LEU A 46ASP A 48ILE A 134GLY A 243 | NoneDBO A1001 (-2.7A)NoneDBO A1001 (-4.2A) | 0.31A | 3bufA-2ewyA:51.6 | 3bufA-2ewyA:52.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5c | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
PF02153(PDH) | 4 | ASP A 62ILE A 58ILE A 68GLY A 37 | NAD A3686 (-2.8A)NoneNoneNAD A3686 (-3.6A) | 0.90A | 3bufA-2g5cA:undetectable | 3bufA-2g5cA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwg | 4-OXALOMESACONATEHYDRATASE (Rhodopseudomonaspalustris) |
PF04909(Amidohydro_2) | 4 | LEU A 270ILE A 321ILE A 274GLY A 224 | None | 0.85A | 3bufA-2gwgA:undetectable | 3bufA-2gwgA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h39 | PROBABLEGALACTOSE-1-PHOSPHATE URIDYL TRANSFERASE (Arabidopsisthaliana) |
PF01087(GalP_UDP_transf)PF02744(GalP_UDP_tr_C) | 4 | LEU A 149ILE A 294ILE A 148GLY A 271 | None | 0.82A | 3bufA-2h39A:undetectable | 3bufA-2h39A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6t | CANDIDAPEPSIN-3 (Candidaalbicans) |
PF00026(Asp) | 4 | LEU A 216ASP A 218ILE A 305GLY A 34 | None | 0.50A | 3bufA-2h6tA:30.8 | 3bufA-2h6tA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7c | BETA-GLUCOSIDASE A (Thermotogamaritima) |
PF00232(Glyco_hydro_1) | 4 | LEU A 392ILE A 331ILE A 386GLY A 394 | None | 0.85A | 3bufA-2j7cA:undetectable | 3bufA-2j7cA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nq5 | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Streptococcusmutans) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 4 | LEU A 577ILE A 521ILE A 574GLY A 539 | None | 0.89A | 3bufA-2nq5A:undetectable | 3bufA-2nq5A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmz | DNA-DIRECTED RNAPOLYMERASE SUBUNIT K (Sulfolobussolfataricus) |
PF01192(RNA_pol_Rpb6) | 4 | LEU K 92ILE K 32ILE K 76GLY K 72 | None | 0.89A | 3bufA-2pmzK:undetectable | 3bufA-2pmzK:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qma | DIAMINOBUTYRATE-PYRUVATE TRANSAMINASEANDL-2,4-DIAMINOBUTYRATE DECARBOXYLASE (Vibrioparahaemolyticus) |
PF00282(Pyridoxal_deC) | 4 | LEU A 738ASP A 736ILE A 780ILE A 741 | None | 0.71A | 3bufA-2qmaA:undetectable | 3bufA-2qmaA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzw | CANDIDAPEPSIN-1 (Candidaalbicans) |
PF00026(Asp) | 4 | LEU A 216ASP A 218ILE A 305GLY A 34 | None | 0.47A | 3bufA-2qzwA:31.4 | 3bufA-2qzwA:25.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 4 | LEU A 216ASP A 218ILE A 305GLY A 34 | None | 0.59A | 3bufA-2qzxA:32.2 | 3bufA-2qzxA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrf | METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE (Bacillussubtilis) |
PF01008(IF-2B) | 4 | ASP A 154ILE A 213ILE A 156GLY A 153 | None | 0.91A | 3bufA-2yrfA:undetectable | 3bufA-2yrfA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 4 | ASP A 53ILE A 48ILE A 83GLY A 8 | NAD A 400 (-2.9A)NoneNoneNAD A 400 (-3.3A) | 0.65A | 3bufA-3cinA:undetectable | 3bufA-3cinA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctp | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Alkaliphilusmetalliredigens) |
PF13377(Peripla_BP_3) | 4 | LEU A 297ILE A 82ILE A 298GLY A 119 | None | 0.72A | 3bufA-3ctpA:undetectable | 3bufA-3ctpA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 4 | LEU A 168ASP A 140ILE A 174GLY A 141 | None | 0.95A | 3bufA-3cwcA:undetectable | 3bufA-3cwcA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1t | HALOGENASE (Chondromycescrocatus) |
PF04820(Trp_halogenase) | 4 | LEU A 117ASP A 114ILE A 58GLY A 16 | NoneNoneNoneFAD A 600 (-3.7A) | 0.83A | 3bufA-3e1tA:undetectable | 3bufA-3e1tA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e48 | PUTATIVENUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Staphylococcusaureus) |
PF13460(NAD_binding_10) | 4 | LEU A 5ILE A 25ILE A 30GLY A 13 | None | 0.91A | 3bufA-3e48A:undetectable | 3bufA-3e48A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fv3 | SAPP1P-SECRETEDASPARTIC PROTEASE 1 (Candidaparapsilosis) |
PF00026(Asp) | 4 | LEU A 218ASP A 220ILE A 303GLY A 34 | None | 0.45A | 3bufA-3fv3A:32.4 | 3bufA-3fv3A:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggg | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
no annotation | 4 | ASP D 62ILE D 58ILE D 68GLY D 37 | NAD D6686 (-2.9A)NoneNoneNAD D6686 (-3.4A) | 0.88A | 3bufA-3gggD:undetectable | 3bufA-3gggD:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3glg | DNA POLYMERASE IIISUBUNIT DELTA' (Escherichiacoli) |
PF09115(DNApol3-delta_C)PF13177(DNA_pol3_delta2) | 4 | LEU E 164ASP E 37ILE E 29GLY E 36 | None | 0.96A | 3bufA-3glgE:undetectable | 3bufA-3glgE:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbu | SECRETED PROTEASE C (Dickeyachrysanthemi) |
PF00353(HemolysinCabind)PF00413(Peptidase_M10)PF08548(Peptidase_M10_C) | 4 | LEU P 361ASP P 377ILE P 315GLY P 372 | None CA P 483 ( 2.4A)None CA P 483 (-4.3A) | 0.95A | 3bufA-3hbuP:undetectable | 3bufA-3hbuP:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ho8 | PYRUVATE CARBOXYLASE (Staphylococcusaureus) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 4 | LEU A 357ILE A 367ILE A 360GLY A 251 | None | 0.86A | 3bufA-3ho8A:undetectable | 3bufA-3ho8A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htx | HEN1 (Arabidopsisthaliana) |
PF13847(Methyltransf_31) | 4 | ASP A 776ILE A 742ILE A 927GLY A 777 | None | 0.87A | 3bufA-3htxA:undetectable | 3bufA-3htxA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j08 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase) | 4 | ASP A 424ILE A 582ILE A 571GLY A 427 | None | 0.95A | 3bufA-3j08A:undetectable | 3bufA-3j08A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6j | PROTEIN F01G10.3,CONFIRMED BYTRANSCRIPT EVIDENCE (Caenorhabditiselegans) |
PF00725(3HCDH)PF02737(3HCDH_N) | 4 | LEU A 67ILE A 56ILE A 106GLY A 47 | None | 0.63A | 3bufA-3k6jA:undetectable | 3bufA-3k6jA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzq | BIOSYNTHETICARGININEDECARBOXYLASE (Escherichiacoli) |
PF02784(Orn_Arg_deC_N) | 4 | ASP A 308ILE A 103ILE A 358GLY A 310 | None | 0.87A | 3bufA-3nzqA:undetectable | 3bufA-3nzqA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oby | PROTEIN PELOTAHOMOLOG (Archaeoglobusfulgidus) |
PF03463(eRF1_1)PF03464(eRF1_2)PF03465(eRF1_3) | 4 | LEU A 232ILE A 189ILE A 229GLY A 150 | None | 0.80A | 3bufA-3obyA:undetectable | 3bufA-3obyA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozi | L6TR (Linumusitatissimum) |
PF01582(TIR) | 4 | ASP A 183ILE A 96ILE A 188GLY A 180 | None | 0.86A | 3bufA-3oziA:undetectable | 3bufA-3oziA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p14 | L-RHAMNOSE ISOMERASE (Bacillushalodurans) |
PF06134(RhaA) | 4 | LEU A 324ILE A 322ILE A 35GLY A 340 | None | 0.68A | 3bufA-3p14A:undetectable | 3bufA-3p14A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv0 | K. POLYSPORUS DCR1 (Vanderwaltozymapolyspora) |
PF00636(Ribonuclease_3) | 4 | LEU A 66ASP A 62ILE A 65GLY A 55 | None | 0.50A | 3bufA-3rv0A:undetectable | 3bufA-3rv0A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv1 | K. POLYSPORUS DCR1 (Vanderwaltozymapolyspora) |
PF00636(Ribonuclease_3) | 4 | LEU A 66ASP A 62ILE A 65GLY A 55 | None | 0.62A | 3bufA-3rv1A:undetectable | 3bufA-3rv1A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 4 | LEU L 453ILE L 276ILE L 452GLY L 283 | None | 0.86A | 3bufA-3uscL:undetectable | 3bufA-3uscL:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3utn | THIOSULFATESULFURTRANSFERASETUM1 (Saccharomycescerevisiae) |
PF00581(Rhodanese) | 4 | LEU X 282ASP X 284ILE X 162GLY X 262 | None | 0.95A | 3bufA-3utnX:undetectable | 3bufA-3utnX:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4p | INTEGRIN ALPHA-4 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | LEU A 342ILE A 367ILE A 345GLY A 403 | None | 0.95A | 3bufA-3v4pA:undetectable | 3bufA-3v4pA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdr | D-3-HYDROXYBUTYRATEDEHYDROGENASE (Alcaligenesfaecalis) |
PF00106(adh_short) | 4 | LEU A 87ILE A 128ILE A 137GLY A 121 | None | 0.89A | 3bufA-3vdrA:undetectable | 3bufA-3vdrA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi1 | ALKALINEMETALLOPROTEINASE (Pseudomonasaeruginosa) |
PF08548(Peptidase_M10_C)PF13583(Reprolysin_4) | 4 | LEU A 349ASP A 365ILE A 303GLY A 360 | None CA A 506 ( 2.7A)None CA A 507 (-4.4A) | 0.96A | 3bufA-3vi1A:undetectable | 3bufA-3vi1A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi1 | ALKALINEMETALLOPROTEINASE (Pseudomonasaeruginosa) |
PF08548(Peptidase_M10_C)PF13583(Reprolysin_4) | 4 | LEU A 358ASP A 374ILE A 303GLY A 369 | None CA A 504 ( 2.5A)None CA A 505 (-4.4A) | 0.94A | 3bufA-3vi1A:undetectable | 3bufA-3vi1A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aq1 | SBSB PROTEIN (Geobacillusstearothermophilus) |
no annotation | 4 | LEU C 503ILE C 506ILE C 545GLY C 548 | None | 0.91A | 3bufA-4aq1C:undetectable | 3bufA-4aq1C:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4etp | SPINDLE POLEBODY-ASSOCIATEDPROTEIN VIK1 (Saccharomycescerevisiae) |
PF16796(Microtub_bd) | 4 | LEU B 530ASP B 529ILE B 550GLY B 526 | None | 0.92A | 3bufA-4etpB:undetectable | 3bufA-4etpB:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0w | PROTEASE CSPB (Clostridiumperfringens) |
PF00082(Peptidase_S8) | 4 | LEU B 471ASP B 470ILE B 503ILE B 530 | NoneEDO B 605 (-2.7A)NoneNone | 0.95A | 3bufA-4i0wB:undetectable | 3bufA-4i0wB:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kq9 | RIBOSE ABCTRANSPORTER,SUBSTRATE BINDINGPROTEIN (Conexibacterwoesei) |
PF13407(Peripla_BP_4) | 4 | LEU A 135ILE A 313ILE A 109GLY A 292 | None | 0.94A | 3bufA-4kq9A:undetectable | 3bufA-4kq9A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l68 | LEUCINE-RICH REPEATPROTEIN KINASE-LIKEPROTEIN (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 4 | ASP A 535ILE A 406ILE A 538GLY A 504 | None | 0.85A | 3bufA-4l68A:undetectable | 3bufA-4l68A:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxl | LYSINE-SPECIFICDEMETHYLASE 4B (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN) | 4 | ASP A 64ILE A 137ILE A 63GLY A 96 | None | 0.86A | 3bufA-4lxlA:undetectable | 3bufA-4lxlA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdp | BETA-GLUCOSIDASE (Humicola grisea) |
PF00232(Glyco_hydro_1) | 4 | LEU A 123ASP A 128ILE A 31GLY A 133 | None | 0.83A | 3bufA-4mdpA:undetectable | 3bufA-4mdpA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p81 | ANCESTRAL PYRRPROTEIN (ORANGE) (syntheticconstruct) |
PF00156(Pribosyltran) | 4 | LEU A 9ILE A 162ILE A 14GLY A 151 | None | 0.93A | 3bufA-4p81A:undetectable | 3bufA-4p81A:18.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rcd | BETA-SECRETASE 1 (Homo sapiens) |
PF00026(Asp) | 5 | LEU A 30ASP A 32ILE A 110ILE A 118GLY A 230 | 3LL A 501 (-4.2A)3LL A 501 (-2.8A)None3LL A 501 (-4.6A)3LL A 501 (-3.0A) | 0.12A | 3bufA-4rcdA:60.0 | 3bufA-4rcdA:99.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5avo | HOMOSERINEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 4 | LEU A 5ILE A 98ILE A 32GLY A 12 | None | 0.89A | 3bufA-5avoA:undetectable | 3bufA-5avoA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aw4 | NA, K-ATPASE ALPHASUBUNIT (Squalusacanthias) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 4 | LEU A 725ASP A 721ILE A 730GLY A 716 | NoneMF4 A2001 ( 4.5A)NoneNone | 0.73A | 3bufA-5aw4A:undetectable | 3bufA-5aw4A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c98 | AGAP007691-PB (Anophelesgambiae) |
PF00079(Serpin) | 4 | ASP A 168ILE A 160ILE A 331GLY A 165 | None | 0.88A | 3bufA-5c98A:undetectable | 3bufA-5c98A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn8 | GTPASE DER (Coxiellaburnetii) |
PF01926(MMR_HSR1)PF14714(KH_dom-like) | 4 | ASP A 56ILE A 103ILE A 7GLY A 58 | GDP A 502 ( 4.7A)NoneNoneNone | 0.80A | 3bufA-5dn8A:undetectable | 3bufA-5dn8A:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ebb | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Homo sapiens) |
PF00149(Metallophos) | 4 | ASP A 153ILE A 136ILE A 129GLY A 109 | None | 0.91A | 3bufA-5ebbA:undetectable | 3bufA-5ebbA:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnx | BETA-GLUCOSIDASE (metagenome) |
PF00232(Glyco_hydro_1) | 4 | LEU A 129ASP A 134ILE A 39GLY A 138 | None | 0.85A | 3bufA-5gnxA:undetectable | 3bufA-5gnxA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdt | SISTER CHROMATIDCOHESION PROTEINPDS5 HOMOLOG B (Homo sapiens) |
no annotation | 4 | LEU A 621ILE A 613ILE A 622GLY A 649 | None | 0.93A | 3bufA-5hdtA:undetectable | 3bufA-5hdtA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hpz | WATER-SOLUBLECHLOROPHYLL PROTEIN (Brassicaceae) |
PF00197(Kunitz_legume) | 4 | LEU A 157ILE A 20ILE A 111GLY A 145 | None | 0.95A | 3bufA-5hpzA:undetectable | 3bufA-5hpzA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i70 | PLASMEPSIN IV (Plasmodiumfalciparum) |
no annotation | 4 | ASP B 34ILE B 114ILE B 123GLY B 216 | None | 0.82A | 3bufA-5i70B:32.2 | 3bufA-5i70B:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idi | 1,4-BETA-D-GLUCANGLUCOHYDROLASE (Thermotoganeapolitana) |
PF00232(Glyco_hydro_1) | 4 | LEU A 390ILE A 329ILE A 384GLY A 392 | None | 0.85A | 3bufA-5idiA:undetectable | 3bufA-5idiA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j04 | ENOLASE (Synechococcuselongatus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | LEU A 274ILE A 283ILE A 273GLY A 289 | None | 0.95A | 3bufA-5j04A:undetectable | 3bufA-5j04A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldr | BETA-D-GALACTOSIDASE (Paracoccus sp.32d) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 4 | ASP B 493ILE B 288ILE B 514GLY B 510 | None | 0.97A | 3bufA-5ldrB:undetectable | 3bufA-5ldrB:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lzl | DELTA-AMINOLEVULINICACID DEHYDRATASE (Pyrobaculumcalidifontis) |
PF00490(ALAD) | 4 | ASP A 32ILE A 332ILE A 28GLY A 31 | None | 0.95A | 3bufA-5lzlA:undetectable | 3bufA-5lzlA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n8p | S-LAYER PROTEIN (Caulobactervibrioides) |
PF00353(HemolysinCabind) | 4 | LEU A 889ASP A 905ILE A 861GLY A 900 | None CA A9012 ( 2.7A)None CA A9012 ( 4.2A) | 0.93A | 3bufA-5n8pA:undetectable | 3bufA-5n8pA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n97 | S-LAYER PROTEIN RSAA (Caulobactervibrioides) |
PF00353(HemolysinCabind) | 4 | LEU A 889ASP A 905ILE A 861GLY A 900 | None CA A9012 ( 2.7A)None CA A9012 ( 4.2A) | 0.93A | 3bufA-5n97A:undetectable | 3bufA-5n97A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT A (Methanothermococcusthermolithotrophicus) |
PF07992(Pyr_redox_2)PF13187(Fer4_9) | 4 | LEU A 199ILE A 547ILE A 196GLY A 179 | NoneFAD A 701 (-3.2A)NoneNone | 0.92A | 3bufA-5odrA:undetectable | 3bufA-5odrA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTEN-CONTAININGFORMYLMETHANOFURANDEHYDROGENASE 2SUBUNIT C (Methanothermobacterwolfeii) |
PF01493(GXGXG) | 4 | ASP C 70ILE C 21ILE C 5GLY C 71 | None | 0.88A | 3bufA-5t5iC:undetectable | 3bufA-5t5iC:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc3 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH)PF00571(CBS) | 4 | ASP A 367ILE A 376ILE A 365GLY A 368 | 5GP A 600 (-2.4A)NoneNone5GP A 600 ( 3.4A) | 0.95A | 3bufA-5tc3A:undetectable | 3bufA-5tc3A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uv4 | PUTATIVELEUCINE-RICH REPEATPROTEIN KINASEFAMILY PROTEIN (Zea mays) |
PF07714(Pkinase_Tyr) | 4 | ASP A 997ILE A 867ILE A1000GLY A 963 | None | 0.85A | 3bufA-5uv4A:undetectable | 3bufA-5uv4A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wua | ATP-SENSITIVE INWARDRECTIFIER POTASSIUMCHANNEL11,SUPERFOLDER GFP (Mus musculus;syntheticconstruct) |
PF01007(IRK) | 4 | LEU A 251ILE A 215ILE A 210GLY A 203 | None | 0.77A | 3bufA-5wuaA:undetectable | 3bufA-5wuaA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7n | DIAMINOPIMELATEDECARBOXYLASE (Corynebacteriumglutamicum) |
no annotation | 4 | ASP A 389ILE A 385ILE A 390GLY A 362 | None | 0.85A | 3bufA-5x7nA:undetectable | 3bufA-5x7nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xei | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusyayanosii) |
PF02463(SMC_N) | 4 | LEU A1095ILE A1099ILE A1125GLY A 43 | None | 0.96A | 3bufA-5xeiA:undetectable | 3bufA-5xeiA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xu1 | ABC TRANSPORTERATP-BINDING PROTEIN (Streptococcuspneumoniae) |
no annotation | 4 | LEU A 167ILE A 39ILE A 165GLY A 55 | None | 0.92A | 3bufA-5xu1A:undetectable | 3bufA-5xu1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yb7 | L-AMINO ACIDOXIDASE/MONOOXYGENASE (Pseudomonas sp.AIU 813) |
no annotation | 4 | ASP A 457ILE A 412ILE A 459GLY A 456 | None | 0.78A | 3bufA-5yb7A:undetectable | 3bufA-5yb7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zhz | PROBABLEENDONUCLEASE 4 (Mycobacteriumtuberculosis) |
no annotation | 4 | LEU A 148ILE A 106ILE A 145GLY A 97 | None | 0.94A | 3bufA-5zhzA:undetectable | 3bufA-5zhzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bcq | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Mus musculus) |
no annotation | 4 | ASP B 280ILE B 289ILE B 279GLY B 306 | None | 0.95A | 3bufA-6bcqB:undetectable | 3bufA-6bcqB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c4g | ASPARTIC PROTEASEPM5 (Plasmodiumvivax) |
no annotation | 4 | LEU A 311ASP A 313ILE A 439GLY A 82 | EQG A 504 ( 4.2A)EQG A 504 (-2.1A)EQG A 504 (-4.3A)EQG A 504 (-3.0A) | 0.53A | 3bufA-6c4gA:32.6 | 3bufA-6c4gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cpy | GRMZM2G135359PSEUDOKINASE (Zea mays) |
no annotation | 4 | ASP A 445ILE A 334ILE A 448GLY A 415 | None | 0.97A | 3bufA-6cpyA:undetectable | 3bufA-6cpyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cu5 | PROTEIN ARGININEN-METHYLTRANSFERASE (Naegleriafowleri) |
no annotation | 4 | ASP A 73ILE A 94ILE A 78GLY A 51 | SAH A 401 (-2.9A)NoneNoneSAH A 401 (-3.1A) | 0.88A | 3bufA-6cu5A:undetectable | 3bufA-6cu5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ej2 | BETA-SECRETASE 1 (Homo sapiens) |
no annotation | 5 | LEU A 439ASP A 441ILE A 519ILE A 527GLY A 639 | B7E A 901 (-4.6A)B7E A 901 (-2.9A)NoneB7E A 901 (-4.4A)B7E A 901 (-3.8A) | 0.39A | 3bufA-6ej2A:59.6 | 3bufA-6ej2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fa5 | PUTATIVE MRNASPLICING FACTOR (Chaetomiumthermophilum) |
no annotation | 4 | LEU A 844ILE A 893ILE A 843GLY A 776 | None | 0.88A | 3bufA-6fa5A:undetectable | 3bufA-6fa5A:undetectable |