SIMILAR PATTERNS OF AMINO ACIDS FOR 3BU1_A_HSMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN

(Clostridium
pasteurianum) 		PF00142
(Fer4_NifH) 		4 TYR A 121
VAL A 123
TYR A   7
ILE A 136
 None
 1.13A 3bu1A-1cp2A:
undetectable		 3bu1A-1cp2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 SER A 220
TYR A 208
VAL A 206
ILE A 195
 None
 0.92A 3bu1A-1cvrA:
undetectable		 3bu1A-1cvrA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 SER A 367
TYR A 332
VAL A 329
TYR A 354
 None
 1.09A 3bu1A-1ddgA:
undetectable		 3bu1A-1ddgA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 SER A 342
TYR A 429
ILE A 280
ASP A 278
 None
 0.98A 3bu1A-1dj3A:
undetectable		 3bu1A-1dj3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 SER A 324
VAL A 390
ASP A 294
TRP A 295
 None
 1.16A 3bu1A-1e8tA:
0.2		 3bu1A-1e8tA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5m GAF

(Saccharomyces
cerevisiae) 		PF13185
(GAF_2) 		4 VAL A  62
TYR A  57
ILE A 133
ASP A 159
 None
 1.20A 3bu1A-1f5mA:
0.0		 3bu1A-1f5mA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 SER A 419
TYR A 336
ILE A 338
ASP A 415
 None
 1.13A 3bu1A-1fohA:
undetectable		 3bu1A-1fohA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 SER A 116
VAL A 149
TYR A 151
ILE A  88
 None
 1.16A 3bu1A-1geyA:
0.0		 3bu1A-1geyA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 VAL A 596
TYR A 619
ILE A 551
TRP A 496
 None
 1.07A 3bu1A-1h54A:
0.0		 3bu1A-1h54A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 VAL A 440
TYR A 487
ILE A 452
ASP A 418
 None
 1.25A 3bu1A-1jf5A:
undetectable		 3bu1A-1jf5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 SER B 168
ILE B 247
ASP B 172
TRP B 244
 None
 1.19A 3bu1A-1mhyB:
undetectable		 3bu1A-1mhyB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 SER A 282
ILE A 279
ASP A 256
TRP A 260
 None
 1.04A 3bu1A-1qsaA:
undetectable		 3bu1A-1qsaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 SER A 708
TYR A 713
ASP A 704
TRP A 722
 None
 1.19A 3bu1A-1sqjA:
undetectable		 3bu1A-1sqjA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 VAL A  78
TYR A  83
ILE A 126
ASP A  68
 None
 1.22A 3bu1A-1vblA:
undetectable		 3bu1A-1vblA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 197
TYR A 207
ILE A 185
ASP A 187
 None
 1.16A 3bu1A-1xkhA:
undetectable		 3bu1A-1xkhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 TYR A 107
VAL A 105
ILE A  76
ASP A 109
 None
 1.05A 3bu1A-1z9aA:
undetectable		 3bu1A-1z9aA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 SER A  18
TYR A  71
ILE A  22
ASP A  12
 None
 1.12A 3bu1A-2ah5A:
undetectable		 3bu1A-2ah5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 SER A 170
VAL A 144
TYR B 164
ILE B 217
 None
 1.17A 3bu1A-2dppA:
undetectable		 3bu1A-2dppA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		4 SER A 199
VAL A 241
TYR A 243
ASP A 195
 None
None
GLU  A1055 (-4.2A)
None
 1.07A 3bu1A-2dvzA:
undetectable		 3bu1A-2dvzA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A

(Aquifex
aeolicus) 		PF12804
(NTP_transf_3) 		4 TYR A 169
VAL A 126
TYR A 141
ILE A 160
 None
 1.24A 3bu1A-2e8bA:
undetectable		 3bu1A-2e8bA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 SER A 774
VAL A 838
ILE A 749
ASP A 753
 None
 1.08A 3bu1A-2ec5A:
undetectable		 3bu1A-2ec5A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A  83
VAL A 120
ILE A 146
ASP A  78
 None
 0.90A 3bu1A-2fjaA:
undetectable		 3bu1A-2fjaA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		4 SER A 210
VAL A 226
ILE A 241
TRP A 199
 None
 1.20A 3bu1A-2gzsA:
undetectable		 3bu1A-2gzsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		4 VAL A 131
TYR A 136
ILE A 141
ASP A 260
 None
 1.22A 3bu1A-2h1rA:
undetectable		 3bu1A-2h1rA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		4 SER A 241
VAL A 213
TYR A 152
ASP A 239
 None
 1.23A 3bu1A-2hqyA:
undetectable		 3bu1A-2hqyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 SER A 240
TYR A 122
TYR A 261
ASP A 242
 GOL  A1979 (-3.5A)
GOL  A1979 (-4.5A)
None
GOL  A1979 (-2.7A)
 1.22A 3bu1A-2ivfA:
undetectable		 3bu1A-2ivfA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		4 SER A 142
VAL A 111
ILE A 158
ASP A  97
 None
 0.88A 3bu1A-2j04A:
undetectable		 3bu1A-2j04A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 VAL A 197
TYR A 207
ILE A 185
ASP A 187
 None
None
None
PO4  A   3 (-4.0A)
 1.15A 3bu1A-2o5pA:
undetectable		 3bu1A-2o5pA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		4 VAL A 177
TYR A 181
ILE A 142
ASP A 135
 None
None
None
SAM  A 400 (-3.4A)
 1.05A 3bu1A-2qe6A:
undetectable		 3bu1A-2qe6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qml BH2621 PROTEIN

(Bacillus
halodurans) 		PF13523
(Acetyltransf_8) 		4 VAL A 168
TYR A  97
ILE A  93
ASP A 172
 None
 1.18A 3bu1A-2qmlA:
undetectable		 3bu1A-2qmlA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v15 DNA PROTECTION
DURING STARVATION
PROTEIN

(Streptococcus
suis) 		PF00210
(Ferritin) 		4 SER A  98
TYR A 124
VAL A 121
ASP A  35
 None
 0.96A 3bu1A-2v15A:
undetectable		 3bu1A-2v15A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 SER A 493
TYR A 397
VAL A 399
TYR A 402
 None
 1.14A 3bu1A-2v5dA:
undetectable		 3bu1A-2v5dA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 325
VAL A 376
ILE A 322
TRP A 321
 None
 1.17A 3bu1A-2wbiA:
undetectable		 3bu1A-2wbiA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN

(Streptococcus
pyogenes) 		PF00210
(Ferritin) 		4 SER A 101
TYR A 127
VAL A 124
ASP A  38
 None
 0.98A 3bu1A-2wlaA:
undetectable		 3bu1A-2wlaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 SER A 259
VAL A 118
ILE A   9
ASP A 263
 None
 1.24A 3bu1A-2wyhA:
undetectable		 3bu1A-2wyhA:
10.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x46 ALLERGEN ARG R 1

(Argas reflexus) 		PF02098
(His_binding) 		7 SER A  28
TYR A  37
VAL A  53
TYR A  67
ILE A  92
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-4.7A)
None
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.53A 3bu1A-2x46A:
25.6		 3bu1A-2x46A:
48.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL A 236
TYR A 250
ILE A 128
ASP A 130
 None
 1.05A 3bu1A-2zvwA:
undetectable		 3bu1A-2zvwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 732
ILE A 663
ASP A 615
TRP A 616
 None
 1.10A 3bu1A-3a2fA:
undetectable		 3bu1A-3a2fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 TYR A 351
VAL A 362
ILE A 343
ASP A 345
 None
 1.07A 3bu1A-3b46A:
undetectable		 3bu1A-3b46A:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3brn LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		6 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.48A 3bu1A-3brnA:
22.3		 3bu1A-3brnA:
42.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqn VIOLAXANTHIN
DE-EPOXIDASE,
CHLOROPLAST

(Arabidopsis
thaliana) 		PF07137
(VDE) 		5 TYR A 198
VAL A 196
TYR A 214
ILE A 105
ASP A 114
 None
 1.42A 3bu1A-3cqnA:
10.4		 3bu1A-3cqnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		4 SER A  17
TYR A  73
ILE A  21
ASP A  11
 None
None
None
PO4  A 251 (-3.5A)
 1.10A 3bu1A-3d6jA:
undetectable		 3bu1A-3d6jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		4 SER A 367
VAL A 278
TYR A 280
ILE A 369
 None
 1.25A 3bu1A-3ec1A:
undetectable		 3bu1A-3ec1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A  58
VAL A   8
ILE A  36
ASP A  57
 None
NAD  A 400 (-4.7A)
NAD  A 400 (-4.0A)
None
 1.23A 3bu1A-3ec7A:
undetectable		 3bu1A-3ec7A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehq OSTEOCLAST-STIMULATI
NG FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		4 SER A  54
TYR A  65
ILE A  39
ASP A  37
 None
 1.21A 3bu1A-3ehqA:
undetectable		 3bu1A-3ehqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 SER A  20
TYR A  29
ASP A 120
TRP A 137
 None
 0.70A 3bu1A-3g7xA:
17.3		 3bu1A-3g7xA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 TYR A  29
VAL A  51
ASP A 120
TRP A 137
 None
 0.55A 3bu1A-3g7xA:
17.3		 3bu1A-3g7xA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 VAL A 175
TYR A 128
ILE A 170
ASP A 185
 None
 1.16A 3bu1A-3gzsA:
undetectable		 3bu1A-3gzsA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		4 SER A 682
VAL A 552
TYR A 606
ILE A 679
 None
 0.96A 3bu1A-3h6zA:
undetectable		 3bu1A-3h6zA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 TYR A 253
VAL A 252
TYR A  48
ASP A  35
 None
 1.25A 3bu1A-3n23A:
undetectable		 3bu1A-3n23A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 SER A 187
VAL A 119
TYR A 121
ASP A 189
 None
 1.15A 3bu1A-3nqhA:
undetectable		 3bu1A-3nqhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxh RV0577 PROTEIN

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 TYR A 161
VAL A 164
ILE A 116
ASP A 118
 None
 1.22A 3bu1A-3oxhA:
undetectable		 3bu1A-3oxhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		4 SER A 136
VAL A 141
ILE A 105
ASP A  77
 CL  A 269 (-4.8A)
None
None
CL  A 269 (-3.7A)
 1.23A 3bu1A-3p8kA:
undetectable		 3bu1A-3p8kA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdf DIPEPTIDYL PEPTIDASE
1

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 TYR A 321
VAL A 431
TYR A 323
ILE A  63
 None
None
CL  A 443 (-4.7A)
None
 1.07A 3bu1A-3pdfA:
undetectable		 3bu1A-3pdfA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 TYR X 256
VAL X 254
TYR X 391
ILE X 264
 None
 1.08A 3bu1A-3qc5X:
undetectable		 3bu1A-3qc5X:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 TYR A 229
VAL A 222
TYR A 178
ASP A 169
 None
 1.21A 3bu1A-3qz4A:
undetectable		 3bu1A-3qz4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4q LACTOYLGLUTATHIONE
LYASE

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		4 TYR A  26
VAL A  29
ILE A 119
ASP A 121
 None
 1.10A 3bu1A-3r4qA:
undetectable		 3bu1A-3r4qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		4 SER A 102
VAL A  24
TYR A  26
TRP A  21
 None
 1.21A 3bu1A-3r5bA:
undetectable		 3bu1A-3r5bA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 SER A 199
VAL A 222
TYR A 227
ASP A 174
 None
 1.14A 3bu1A-3sxfA:
undetectable		 3bu1A-3sxfA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0t PERAKINE REDUCTASE

(Rauvolfia
serpentina) 		PF00248
(Aldo_ket_red) 		4 TYR A 119
VAL A 117
ILE A  79
ASP A 121
 None
 1.16A 3bu1A-3v0tA:
undetectable		 3bu1A-3v0tA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 SER A 152
VAL A1072
ILE A 149
ASP A 156
 None
 1.23A 3bu1A-3zgxA:
undetectable		 3bu1A-3zgxA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00215
(OMPdecase) 		4 TYR A 183
VAL A 162
TYR A 109
ILE A  57
 None
 1.13A 3bu1A-4dbeA:
undetectable		 3bu1A-4dbeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 SER A 324
VAL A 390
ASP A 294
TRP A 295
 None
 1.15A 3bu1A-4fzhA:
undetectable		 3bu1A-4fzhA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 TYR A 118
VAL A 116
ILE A  83
ASP A 120
 None
 1.19A 3bu1A-4h8nA:
undetectable		 3bu1A-4h8nA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf7 PUTATIVE
ACYLHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		4 SER A  90
VAL A 153
ILE A 134
ASP A 117
 None
 0.98A 3bu1A-4hf7A:
undetectable		 3bu1A-4hf7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgn 2-KETO-3-DEOXY-D-MAN
NO-OCTULOSONATE
8-PHOSPHATE
PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 SER A  84
VAL A 117
TYR A 107
ILE A  60
 None
 1.24A 3bu1A-4hgnA:
undetectable		 3bu1A-4hgnA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		4 SER A  82
VAL A 145
ILE A 126
ASP A 109
 None
 1.06A 3bu1A-4iyjA:
undetectable		 3bu1A-4iyjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		4 SER A 173
TYR A 195
VAL A 279
ILE A 203
 None
 1.22A 3bu1A-4jzxA:
undetectable		 3bu1A-4jzxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 SER A 107
VAL A  13
TYR A 111
ILE A 103
 None
 1.23A 3bu1A-4lgvA:
undetectable		 3bu1A-4lgvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		4 SER A 177
VAL A 187
TYR A  61
ILE A 174
 None
 1.05A 3bu1A-4n30A:
undetectable		 3bu1A-4n30A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 SER A  94
TYR A 339
ILE A 300
TRP A 303
 None
 1.05A 3bu1A-4ovkA:
undetectable		 3bu1A-4ovkA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN

(Schistosoma
mansoni) 		PF00188
(CAP) 		4 TYR A  81
TYR A  58
ASP A  90
TRP A  91
 None
 1.25A 3bu1A-4p27A:
undetectable		 3bu1A-4p27A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		4 TYR A 206
VAL A 199
TYR A 140
ASP A 132
 None
 1.10A 3bu1A-4qqsA:
undetectable		 3bu1A-4qqsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 VAL U 238
TYR U 236
ILE U 130
ASP U 163
 None
 1.10A 3bu1A-4qtiU:
undetectable		 3bu1A-4qtiU:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 SER A 417
VAL A 100
TYR A 144
ASP A 420
 None
 0.92A 3bu1A-4rgjA:
undetectable		 3bu1A-4rgjA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1

(Saccharomyces
cerevisiae) 		PF02383
(Syja_N) 		4 SER X  94
VAL X  53
TYR X   7
ILE X  72
 None
 1.22A 3bu1A-4tu3X:
undetectable		 3bu1A-4tu3X:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 SER A 286
VAL A 324
TYR A 322
ILE A 347
 None
 1.10A 3bu1A-4u0tA:
undetectable		 3bu1A-4u0tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 SER A 260
TYR A 235
VAL A 126
ILE A 274
 None
 1.24A 3bu1A-4xhjA:
undetectable		 3bu1A-4xhjA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1g UNCHARACTERIZED
PROTEIN SAV1875

(Staphylococcus
aureus) 		PF01965
(DJ-1_PfpI) 		4 VAL A  51
TYR A  18
ILE A   7
ASP A  54
 None
 0.97A 3bu1A-4y1gA:
undetectable		 3bu1A-4y1gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 SER B  83
TYR B  69
VAL B 166
ILE B  80
 PG4  B 303 ( 4.9A)
None
None
None
 1.07A 3bu1A-4zohB:
undetectable		 3bu1A-4zohB:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Mus musculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 SER A 190
VAL A 185
ILE A 242
ASP A 188
 None
 1.25A 3bu1A-4zw2A:
undetectable		 3bu1A-4zw2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 SER A 493
TYR A 397
VAL A 399
TYR A 402
 None
 1.17A 3bu1A-4zxlA:
undetectable		 3bu1A-4zxlA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 SER A1342
VAL A1738
TYR A1596
ILE A1730
 None
 1.15A 3bu1A-5amqA:
undetectable		 3bu1A-5amqA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 SER A1210
TYR A1140
VAL A1143
ASP A1207
 None
 1.24A 3bu1A-5b2oA:
undetectable		 3bu1A-5b2oA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		4 SER A 127
TYR A 133
VAL A 134
TRP A 130
 None
 1.15A 3bu1A-5ecjA:
undetectable		 3bu1A-5ecjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 SER A 239
TYR A 384
ILE A 389
TRP A 388
 None
 1.05A 3bu1A-5g0aA:
undetectable		 3bu1A-5g0aA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 TYR A 130
VAL A 119
TYR A 115
ILE A 339
 None
 1.21A 3bu1A-5gheA:
undetectable		 3bu1A-5gheA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 VAL A 395
TYR A 399
ASP A 417
TRP A 257
 None
 0.94A 3bu1A-5izdA:
undetectable		 3bu1A-5izdA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		4 SER A1203
TYR A1189
VAL A1185
ILE A1215
 None
 1.14A 3bu1A-5j68A:
undetectable		 3bu1A-5j68A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1

(Saccharomyces
cerevisiae) 		PF09757
(Arb2) 		4 SER A 646
VAL A 603
TYR A 599
ILE A 648
 None
 0.81A 3bu1A-5j8jA:
undetectable		 3bu1A-5j8jA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.17A 3bu1A-5k8fA:
undetectable		 3bu1A-5k8fA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 TYR A 130
VAL A 119
TYR A 115
ILE A 339
 None
 1.24A 3bu1A-5kucA:
undetectable		 3bu1A-5kucA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 4 TYR A 384
VAL A 389
ILE A 298
ASP A 311
 None
 1.03A 3bu1A-5n72A:
undetectable		 3bu1A-5n72A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 SER B 337
TYR B 117
ILE B 132
ASP B 128
 None
 0.83A 3bu1A-5nemB:
undetectable		 3bu1A-5nemB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngw OPGH99A

(Ochrovirga
pacifica) 		no annotation 4 SER A 323
TYR A 211
VAL A 176
TYR A 169
 None
 1.17A 3bu1A-5ngwA:
undetectable		 3bu1A-5ngwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 VAL A  91
TYR A 307
ILE A 317
ASP A 265
 None
 1.11A 3bu1A-5vemA:
undetectable		 3bu1A-5vemA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 TYR A 327
TYR A 325
ILE A 317
ASP A 301
 None
 1.19A 3bu1A-5xhqA:
undetectable		 3bu1A-5xhqA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica) 		no annotation 4 VAL A 487
TYR B  10
ILE A 440
TRP A 465
 None
 1.12A 3bu1A-6ch3A:
undetectable		 3bu1A-6ch3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 4 SER C 656
VAL C 547
TYR C 551
ILE C 650
 None
 1.24A 3bu1A-6f5oC:
undetectable		 3bu1A-6f5oC:
18.46