SIMILAR PATTERNS OF AMINO ACIDS FOR 3BSZ_E_RTLE177

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		5 LEU A  82
ALA A  43
VAL A  77
LEU A  16
HIS A 440
 None
 1.28A 3bszE-1b1yA:
0.0		 3bszE-1b1yA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		5 LEU A  84
ALA A  45
VAL A  79
LEU A  18
HIS A 442
 None
 1.13A 3bszE-1btcA:
0.0		 3bszE-1btcA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 5 LEU A 235
ALA A 128
ALA A 127
VAL A 239
HIS A 228
 None
 0.96A 3bszE-1hpgA:
0.0		 3bszE-1hpgA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  43
ALA A  57
VAL A  61
MET A  73
MET A  88
LEU A  97
GLN A  98
HIS A 104
PHE A 135
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 4.1A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.2A)
 0.43A 3bszE-1iiuA:
30.1		 3bszE-1iiuA:
85.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		7 LEU A  37
ALA A  57
VAL A  61
MET A  73
LEU A  97
GLN A  98
HIS A 117
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.29A 3bszE-1iiuA:
30.1		 3bszE-1iiuA:
85.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 LEU A 252
ALA A 264
ALA A 256
VAL A 247
MET A 301
 None
 1.29A 3bszE-1jroA:
0.0		 3bszE-1jroA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 LEU A 419
ALA A 423
VAL A 415
LEU A 222
GLN A 297
 None
 1.31A 3bszE-1l5aA:
0.0		 3bszE-1l5aA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 LEU A 313
ALA A 276
VAL A 309
LEU A 400
PHE A 318
 None
 1.27A 3bszE-1rq1A:
undetectable		 3bszE-1rq1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.) 		PF08787
(Alginate_lyase2) 		5 LEU A 216
ALA A 116
ALA A 192
VAL A  54
LEU A  13
 None
 0.96A 3bszE-1uaiA:
0.0		 3bszE-1uaiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		5 ALA A 193
ALA A 192
VAL A 213
LEU A 230
GLN A 225
 None
 1.28A 3bszE-1uuoA:
undetectable		 3bszE-1uuoA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		5 LEU A 314
ALA A 309
VAL A 338
MET A 238
LEU A 249
 None
 1.28A 3bszE-1w55A:
undetectable		 3bszE-1w55A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		5 LEU A2334
ALA A2311
ALA A2314
LEU A2321
GLN A2322
 None
 1.21A 3bszE-1xktA:
undetectable		 3bszE-1xktA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 140
ALA A 164
ALA A 165
VAL A 146
MET A 224
 None
None
None
None
NAP  A 801 ( 4.0A)
 1.28A 3bszE-1yb5A:
undetectable		 3bszE-1yb5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		5 LEU A 156
ALA A 231
VAL A 159
LEU A 110
PHE A 226
 None
 1.30A 3bszE-1yw1A:
undetectable		 3bszE-1yw1A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 LEU A  17
ALA A 231
ALA A 228
VAL A  59
MET A 225
 None
 1.23A 3bszE-1z34A:
undetectable		 3bszE-1z34A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 LEU A  17
ALA A 231
ALA A 232
VAL A  59
LEU A  33
 None
 1.33A 3bszE-1z34A:
undetectable		 3bszE-1z34A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 LEU A  80
ALA A 111
ALA A 219
VAL A  55
LEU A  15
 NAD  A 242 (-4.1A)
CIT  A1585 ( 3.1A)
NAD  A 242 (-3.2A)
None
None
 1.09A 3bszE-2dc1A:
undetectable		 3bszE-2dc1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13411
(MerR_1) 		5 LEU A  89
ALA A  84
ALA A  85
VAL A 189
LEU A  49
 None
 1.14A 3bszE-2dg6A:
undetectable		 3bszE-2dg6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 127
ALA A 325
ALA A 417
VAL A 130
LEU A 305
 None
 1.30A 3bszE-2iikA:
undetectable		 3bszE-2iikA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 238
ALA A 218
ALA A 214
VAL A 237
GLN A 208
 None
 1.19A 3bszE-2jbmA:
undetectable		 3bszE-2jbmA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		5 LEU A1968
ALA A1906
ALA A1903
VAL A1964
LEU A1896
 None
 1.30A 3bszE-2kvpA:
undetectable		 3bszE-2kvpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00027
(cNMP_binding) 		5 LEU A  98
ALA A  32
ALA A  92
MET A  55
LEU A  67
 None
 1.29A 3bszE-2mhfA:
undetectable		 3bszE-2mhfA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ock VALACYCLOVIR
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 LEU A  47
ALA A 101
ALA A 104
VAL A  75
LEU A 111
 None
 1.11A 3bszE-2ockA:
undetectable		 3bszE-2ockA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of3 ZYG-9

(Caenorhabditis
elegans) 		no annotation 5 LEU A 652
ALA A 666
ALA A 667
LEU A 689
HIS A 658
 None
 1.14A 3bszE-2of3A:
undetectable		 3bszE-2of3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A  53
ALA A  13
ALA A  12
VAL A  51
GLN A  37
 None
UD1  A4000 (-3.3A)
None
None
None
 1.20A 3bszE-2oi6A:
undetectable		 3bszE-2oi6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		5 ALA A 248
VAL A 105
LEU A 175
GLN A 174
GLN A 190
 None
 1.26A 3bszE-2qi9A:
undetectable		 3bszE-2qi9A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 LEU A 508
ALA A 524
VAL A 505
GLN A 706
PHE A 519
 None
 1.27A 3bszE-2wghA:
undetectable		 3bszE-2wghA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 LEU A 188
ALA A 183
VAL A 189
LEU A 218
PHE A 150
 None
 1.30A 3bszE-2wk8A:
undetectable		 3bszE-2wk8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 LEU A 413
ALA A 324
VAL A 409
LEU A 524
PHE A 391
 None
 1.27A 3bszE-2wokA:
undetectable		 3bszE-2wokA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ALA A  43
VAL A  61
MET A  88
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 1.28A 3bszE-2wq9A:
30.4		 3bszE-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  43
ALA A  57
MET A  73
MET A  88
LEU A  97
GLN A  98
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.55A 3bszE-2wq9A:
30.4		 3bszE-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		9 LEU A  37
ALA A  43
VAL A  61
MET A  88
LEU A  97
GLN A  98
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.88A 3bszE-2wq9A:
30.4		 3bszE-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ALA A 566
ALA A 537
VAL A 533
LEU A 551
GLN A 552
 None
 1.28A 3bszE-2xf2A:
undetectable		 3bszE-2xf2A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 LEU A 453
ALA A 410
ALA A 413
VAL A 259
LEU A 420
 None
 1.21A 3bszE-2xqyA:
undetectable		 3bszE-2xqyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		5 ALA A 164
ALA A 166
VAL A 125
LEU A   5
HIS A 183
 None
 1.24A 3bszE-3bw2A:
undetectable		 3bszE-3bw2A:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ALA A  43
ALA A  57
MET A  73
MET A  88
GLN A  98
HIS A 104
 2T1  A 184 ( 4.7A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.95A 3bszE-3fmzA:
29.3		 3bszE-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ALA A  43
ALA A  57
MET A  88
GLN A  98
HIS A 104
GLN A 117
 2T1  A 184 ( 4.7A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
None
 0.77A 3bszE-3fmzA:
29.3		 3bszE-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  57
MET A  88
HIS A 104
GLN A 117
PHE A 135
 2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
None
2T1  A 184 (-4.8A)
 1.04A 3bszE-3fmzA:
29.3		 3bszE-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  37
ALA A  43
ALA A  57
VAL A  61
MET A  73
MET A  88
HIS A 104
PHE A 135
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.7A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
2T1  A 184 (-4.8A)
 0.92A 3bszE-3fmzA:
29.3		 3bszE-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  37
ALA A  43
ALA A  57
VAL A  61
MET A  88
HIS A 104
GLN A 117
PHE A 135
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.7A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
None
2T1  A 184 (-4.8A)
 0.77A 3bszE-3fmzA:
29.3		 3bszE-3fmzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 442
ALA A 351
ALA A 459
LEU A 370
GLN A 366
 None
 1.29A 3bszE-3igoA:
undetectable		 3bszE-3igoA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  99
ALA A 100
VAL A  38
LEU A  75
GLN A  72
 None
 1.30A 3bszE-3ik4A:
undetectable		 3bszE-3ik4A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00380
(Ribosomal_S9)
PF00411
(Ribosomal_S11) 		5 LEU k  85
ALA I  89
VAL k  83
LEU k 114
GLN I 101
 None
 1.18A 3bszE-3jd5k:
undetectable		 3bszE-3jd5k:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 LEU A 294
ALA A 298
ALA A 297
VAL A 290
LEU A 310
 None
 1.17A 3bszE-3o82A:
undetectable		 3bszE-3o82A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 170
ALA A  33
ALA A   8
LEU A 374
GLN A   4
 None
 1.26A 3bszE-3p4sA:
undetectable		 3bszE-3p4sA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 5 ALA A 387
ALA A 388
VAL A 397
MET A 136
PHE A 115
 None
 1.24A 3bszE-3picA:
undetectable		 3bszE-3picA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 LEU A 135
ALA A  67
ALA A  61
VAL A 222
LEU A 312
 None
 1.30A 3bszE-3s8mA:
undetectable		 3bszE-3s8mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 185
ALA A 126
ALA A 127
VAL A 137
LEU A 152
 None
 1.28A 3bszE-3shoA:
undetectable		 3bszE-3shoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		5 ALA A 174
ALA A 213
VAL A 218
LEU A 206
GLN A 205
 None
 1.04A 3bszE-3tghA:
undetectable		 3bszE-3tghA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uav PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus cereus) 		PF01048
(PNP_UDP_1) 		5 LEU A  17
ALA A 231
ALA A 232
VAL A  59
LEU A  33
 None
 1.32A 3bszE-3uavA:
undetectable		 3bszE-3uavA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 LEU A 943
ALA A 869
MET A 870
LEU A 879
GLN A 862
 None
 1.27A 3bszE-3ummA:
undetectable		 3bszE-3ummA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo0 ALANINE-ANTICAPSIN
LIGASE BACD

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		5 LEU A 110
ALA A  39
ALA A  77
VAL A 217
LEU A 182
 None
 1.25A 3bszE-3wo0A:
undetectable		 3bszE-3wo0A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		5 LEU A 118
ALA A 102
ALA A 105
LEU A 113
PHE A 138
 None
 1.27A 3bszE-3wr7A:
undetectable		 3bszE-3wr7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		5 LEU A 213
ALA A 241
ALA A 220
VAL A 171
LEU A 272
 None
 1.30A 3bszE-3wwhA:
undetectable		 3bszE-3wwhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
tuberculosis) 		PF00797
(Acetyltransf_2) 		5 LEU A 249
ALA A 211
ALA A 210
VAL A 246
HIS A  73
 None
 1.26A 3bszE-4bgfA:
undetectable		 3bszE-4bgfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A  39
ALA A  38
VAL A  92
MET A  45
LEU A  57
 None
 1.27A 3bszE-4eqaA:
undetectable		 3bszE-4eqaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		5 LEU A 178
ALA A 150
ALA A 147
LEU A 140
PHE A 204
 None
 1.20A 3bszE-4finA:
undetectable		 3bszE-4finA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 LEU A 293
ALA A 244
LEU A 278
HIS A 269
GLN A 267
 LEU  A 293 ( 0.5A)
ALA  A 244 ( 0.0A)
LEU  A 278 ( 0.5A)
HIS  A 269 ( 1.0A)
GLN  A 267 ( 0.6A)
 1.30A 3bszE-4g9kA:
undetectable		 3bszE-4g9kA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 ALA A  70
VAL A 412
GLN A 185
GLN A 247
PHE A 252
 None
 1.31A 3bszE-4gs1A:
undetectable		 3bszE-4gs1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je1 PROBABLE THIOL
PEROXIDASE

(Burkholderia
cenocepacia) 		PF08534
(Redoxin) 		5 LEU A  49
ALA A  25
ALA A  24
VAL A  48
PHE A 114
 None
 1.19A 3bszE-4je1A:
undetectable		 3bszE-4je1A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF16024
(DUF4785) 		5 LEU A 364
VAL A 385
LEU A  22
HIS A  44
PHE A 351
 None
 1.31A 3bszE-4kh9A:
undetectable		 3bszE-4kh9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		5 LEU A 146
ALA A  53
ALA A  54
VAL A 149
LEU A 106
 None
 1.28A 3bszE-4mx8A:
undetectable		 3bszE-4mx8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4og1 ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 LEU A  58
VAL A 110
MET A  36
LEU A  47
PHE A  65
 None
 1.05A 3bszE-4og1A:
undetectable		 3bszE-4og1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2j DNA-BINDING PROTEIN
SATB1

(Mus musculus) 		PF16534
(ULD)
PF16557
(CUTL) 		5 LEU A 170
ALA A 126
ALA A 125
VAL A  80
LEU A 118
 None
 1.11A 3bszE-4q2jA:
undetectable		 3bszE-4q2jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 ALA A 656
MET A 622
LEU A 538
HIS A 584
GLN A 582
 None
 1.33A 3bszE-4qnlA:
undetectable		 3bszE-4qnlA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 5 LEU C 269
ALA C 225
MET C 257
MET C 278
LEU C 290
 None
 1.19A 3bszE-4rwtC:
undetectable		 3bszE-4rwtC:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  92
ALA A 295
ALA A 386
VAL A  95
LEU A 389
 None
 1.31A 3bszE-4wyrA:
undetectable		 3bszE-4wyrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 ALA A 183
ALA A 182
LEU A 269
GLN A 153
GLN A  96
 None
RAM  A 401 ( 3.7A)
RAM  A 401 ( 3.9A)
RAM  A 401 (-4.1A)
None
 1.25A 3bszE-4wzzA:
undetectable		 3bszE-4wzzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 LEU A 277
ALA A 303
VAL A 273
LEU A 343
GLN A 346
 None
 1.19A 3bszE-4y21A:
undetectable		 3bszE-4y21A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 ALA A 253
ALA A 254
LEU A 439
HIS A 336
PHE A 212
 None
None
None
MN  A 501 ( 3.5A)
GOA  A 506 (-3.5A)
 1.23A 3bszE-4zwoA:
undetectable		 3bszE-4zwoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 LEU A1585
ALA A1410
ALA A1372
MET A1373
LEU A1307
 None
 1.17A 3bszE-5a31A:
undetectable		 3bszE-5a31A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ALA A 186
ALA A 173
VAL A 232
LEU A 281
GLN A 284
 None
 1.31A 3bszE-5a3fA:
undetectable		 3bszE-5a3fA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab8 GROUP 1 TRUNCATED
HEMOGLOBIN GLBN

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		5 LEU A 122
ALA A  64
ALA A  65
VAL A 126
GLN A  58
 None
ACT  A1130 ( 4.0A)
ACT  A1130 ( 4.0A)
None
HEM  A 144 ( 3.1A)
 1.27A 3bszE-5ab8A:
undetectable		 3bszE-5ab8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		5 ALA A 123
ALA A  74
VAL A  17
MET A 187
LEU A  55
 None
 1.27A 3bszE-5aypA:
undetectable		 3bszE-5aypA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 288
ALA A  70
ALA A  69
VAL A 291
MET A  65
 None
 1.31A 3bszE-5b37A:
undetectable		 3bszE-5b37A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 LEU E 567
ALA E 724
ALA E 725
VAL E 563
LEU E 757
 None
 0.99A 3bszE-5c4gE:
undetectable		 3bszE-5c4gE:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 LEU A 322
ALA A 268
VAL A  87
MET A 266
LEU A 264
 None
 1.26A 3bszE-5d8gA:
undetectable		 3bszE-5d8gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 LEU A 259
ALA A 339
ALA A 263
VAL A 227
LEU A 287
 None
 1.26A 3bszE-5esoA:
undetectable		 3bszE-5esoA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A  25
ALA A  28
ALA A 182
LEU A  12
GLN A 148
 None
 1.30A 3bszE-5f7cA:
undetectable		 3bszE-5f7cA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 ALA A  29
VAL A 375
GLN A 148
GLN A 210
PHE A 215
 None
 1.20A 3bszE-5fw4A:
undetectable		 3bszE-5fw4A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan SPLICEOSOMAL PROTEIN
DIB1

(Saccharomyces
cerevisiae) 		PF02966
(DIM1) 		5 LEU D 103
VAL D  82
MET D 113
LEU D  46
HIS D 139
 None
 1.30A 3bszE-5ganD:
undetectable		 3bszE-5ganD:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ALA A 151
ALA A 192
VAL A 156
LEU A 229
PHE A 107
 None
 1.24A 3bszE-5h3kA:
undetectable		 3bszE-5h3kA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		5 LEU A1493
ALA A1518
MET A1515
LEU A1478
GLN A1634
 None
 1.14A 3bszE-5h64A:
undetectable		 3bszE-5h64A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 LEU B 162
ALA B 133
ALA B 136
VAL B 151
LEU B  85
 None
 1.21A 3bszE-5hzgB:
undetectable		 3bszE-5hzgB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU A1143
ALA A1151
ALA A1154
VAL A1352
LEU A1161
 None
 0.95A 3bszE-5iy9A:
undetectable		 3bszE-5iy9A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		5 LEU B 178
ALA B 171
ALA B 197
MET B 196
LEU B 114
 None
 1.30A 3bszE-5k5aB:
undetectable		 3bszE-5k5aB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 LEU A 526
ALA A 547
ALA A 546
VAL A 479
GLN A 430
 None
 1.18A 3bszE-5kdxA:
undetectable		 3bszE-5kdxA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 LEU A1585
ALA A1410
ALA A1372
MET A1373
LEU A1307
 None
 1.09A 3bszE-5lcwA:
undetectable		 3bszE-5lcwA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 LEU H  38
ALA H  73
VAL H  43
MET H  75
MET H  53
 None
 1.25A 3bszE-5lp7H:
undetectable		 3bszE-5lp7H:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 5 LEU A 172
ALA A 105
VAL A 159
LEU A  51
PHE A 441
 None
 1.21A 3bszE-5m3xA:
undetectable		 3bszE-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Streptosporangium
roseum) 		no annotation 5 LEU A   9
ALA A  50
ALA A  56
VAL A  65
LEU A  84
 None
 1.24A 3bszE-5ocmA:
undetectable		 3bszE-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odj SINGLE-STRANDED
DNA-BINDING PROTEIN

(Enterobacter
phage Enc34) 		no annotation 5 LEU A  51
ALA A 162
ALA A 111
VAL A 143
LEU A  33
 None
 1.29A 3bszE-5odjA:
undetectable		 3bszE-5odjA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odk SINGLE-STRANDED
DNA-BINDING PROTEIN

(Enterobacter
phage Enc34) 		no annotation 5 LEU A  51
ALA A 162
ALA A 111
VAL A 143
LEU A  33
 None
 1.32A 3bszE-5odkA:
undetectable		 3bszE-5odkA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 5 ALA A 307
ALA A  84
VAL A 452
LEU A  78
GLN A  77
 None
 1.30A 3bszE-5oevA:
undetectable		 3bszE-5oevA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 508
ALA A 524
VAL A 505
GLN A 706
PHE A 519
 None
 1.26A 3bszE-5tusA:
undetectable		 3bszE-5tusA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 LEU A1209
ALA A1235
VAL A1205
LEU A1275
GLN A1278
 None
 1.21A 3bszE-5ue8A:
undetectable		 3bszE-5ue8A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 5 LEU A  23
ALA A  65
ALA A  62
MET A  59
LEU A  11
 None
 1.21A 3bszE-5wlyA:
undetectable		 3bszE-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 216
ALA A  69
ALA A  68
LEU A 228
GLN A 232
 None
 1.15A 3bszE-5x5hA:
undetectable		 3bszE-5x5hA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 5 LEU A 120
ALA A 104
ALA A 107
LEU A 115
PHE A 140
 None
 1.20A 3bszE-6d72A:
undetectable		 3bszE-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 5 LEU B  15
ALA B 159
VAL B  26
LEU B  11
PHE B 174
 None
 1.25A 3bszE-6dexB:
undetectable		 3bszE-6dexB:
undetectable