SIMILAR PATTERNS OF AMINO ACIDS FOR 3BRF_A_SORA2_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		3 LYS A 249
LYS A 104
VAL A 105
 None
 1.08A 3brfA-1a6cA:
0.0		 3brfA-1a6cA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		3 LYS A  99
LYS A 111
VAL A 113
 None
 1.03A 3brfA-1alqA:
undetectable		 3brfA-1alqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		3 LYS A 326
LYS A 311
VAL A 314
 None
 1.10A 3brfA-1bt4A:
undetectable		 3brfA-1bt4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cl7 PROTEIN (IGG1
ANTIBODY 1696
(VARIABLE HEAVY
CHAIN))

(Mus musculus) 		PF07686
(V-set) 		3 LYS H  12
LYS H  19
VAL H  18
 None
 1.10A 3brfA-1cl7H:
1.2		 3brfA-1cl7H:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo0 TRANSCRIPTION
ELONGATION FACTOR
S-II

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		3 LYS A  52
LYS A  45
VAL A  48
 None
 0.99A 3brfA-1eo0A:
undetectable		 3brfA-1eo0A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 LYS C 276
LYS C 240
VAL C 243
 None
 1.10A 3brfA-1ffvC:
0.0		 3brfA-1ffvC:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS B  12
LYS B  19
VAL B  18
 None
 1.08A 3brfA-1fj1B:
1.8		 3brfA-1fj1B:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		3 LYS A 435
LYS A 423
VAL A 425
 None
 0.92A 3brfA-1fvfA:
undetectable		 3brfA-1fvfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4d REPRESSOR PROTEIN C

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1) 		3 LYS A  46
LYS A  56
VAL A  58
 None
 0.89A 3brfA-1g4dA:
undetectable		 3brfA-1g4dA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		3 LYS A3002
LYS A3033
VAL A3000
 None
 0.98A 3brfA-1miuA:
0.0		 3brfA-1miuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		3 LYS A3002
LYS A3033
VAL A3000
 None
 0.97A 3brfA-1mjeA:
0.0		 3brfA-1mjeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4n FLORAL DEFENSIN-LIKE
PROTEIN 1

(Petunia x
hybrida) 		PF00304
(Gamma-thionin) 		3 LYS A  25
LYS A  18
VAL A  21
 None
 1.08A 3brfA-1n4nA:
undetectable		 3brfA-1n4nA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk0 CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA) 		3 LYS A 297
LYS A 292
VAL A 295
 None
 1.04A 3brfA-1pk0A:
undetectable		 3brfA-1pk0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s05 CYTOCHROME C-556

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		3 LYS A  42
LYS A  91
VAL A  93
 None
 0.68A 3brfA-1s05A:
undetectable		 3brfA-1s05A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		3 LYS A 115
LYS A 155
VAL A 156
 None
 1.04A 3brfA-1sqwA:
undetectable		 3brfA-1sqwA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		3 LYS A 174
LYS A 102
VAL A 176
 None
 0.79A 3brfA-1wdnA:
undetectable		 3brfA-1wdnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02347
(GDC-P)
PF02347
(GDC-P) 		3 LYS A 348
LYS B  21
VAL B  20
 None
 0.84A 3brfA-1wytA:
undetectable		 3brfA-1wytA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Thermus
thermophilus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 LYS A 190
LYS A 198
VAL A 199
 None
 1.04A 3brfA-1x1oA:
undetectable		 3brfA-1x1oA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 LYS A 148
LYS A  11
VAL A 146
 None
 0.79A 3brfA-1xl8A:
undetectable		 3brfA-1xl8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 LYS A 310
LYS A 137
VAL A 136
 None
 1.07A 3brfA-2cdaA:
undetectable		 3brfA-2cdaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct6 SH3 DOMAIN-BINDING
GLUTAMIC
ACID-RICH-LIKE
PROTEIN 2

(Homo sapiens) 		PF04908
(SH3BGR) 		3 LYS A  65
LYS A  58
VAL A  60
 None
 1.09A 3brfA-2ct6A:
undetectable		 3brfA-2ct6A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1h 109AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR

(Sulfurisphaera
tokodaii) 		PF01978
(TrmB) 		3 LYS A   3
LYS A  29
VAL A  31
 None
 1.01A 3brfA-2d1hA:
undetectable		 3brfA-2d1hA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		3 LYS A   1
LYS A  94
VAL A   4
 None
 0.86A 3brfA-2dutA:
undetectable		 3brfA-2dutA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		3 LYS A  28
LYS A   0
VAL A   3
 None
 1.05A 3brfA-2gdzA:
undetectable		 3brfA-2gdzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 LYS A 125
LYS A 130
VAL A 145
 None
 0.93A 3brfA-2gouA:
undetectable		 3brfA-2gouA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13343
(SBP_bac_6) 		3 LYS A 185
LYS A 142
VAL A 145
 None
 0.71A 3brfA-2qryA:
undetectable		 3brfA-2qryA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		3 LYS A 120
LYS A 152
VAL A 116
 None
 1.08A 3brfA-2rg2A:
undetectable		 3brfA-2rg2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 LYS A 148
LYS A 141
VAL A 144
 None
 1.09A 3brfA-2uwfA:
undetectable		 3brfA-2uwfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xha TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		no annotation 3 LYS A 159
LYS A 186
VAL A  95
 None
 1.05A 3brfA-2xhaA:
undetectable		 3brfA-2xhaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		3 LYS A  29
LYS A  33
VAL A  31
 None
 1.09A 3brfA-2ywdA:
undetectable		 3brfA-2ywdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		3 LYS A  61
LYS A  47
VAL A  49
 None
 1.05A 3brfA-2z9vA:
undetectable		 3brfA-2z9vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		3 LYS A  72
LYS A 220
VAL A 219
 None
 0.93A 3brfA-3gmiA:
undetectable		 3brfA-3gmiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		3 LYS A 180
LYS A 152
VAL A 184
 None
 0.99A 3brfA-3js3A:
undetectable		 3brfA-3js3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kev GALIERIA SULFURARIA
DCUN1
DOMAIN-CONTAINING
PROTEIN

(Galdieria
sulphuraria) 		PF03556
(Cullin_binding) 		3 LYS A   6
LYS A  63
VAL A  66
 ACT  A 202 (-2.6A)
None
ACT  A 202 ( 4.4A)
 0.81A 3brfA-3kevA:
undetectable		 3brfA-3kevA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 LYS A  57
LYS A  51
VAL A  52
 None
 1.11A 3brfA-3l7gA:
undetectable		 3brfA-3l7gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m63 UBIQUITIN
DOMAIN-CONTAINING
PROTEIN DSK2

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin) 		3 LYS B  28
LYS B  52
VAL B  24
 None
 1.04A 3brfA-3m63B:
undetectable		 3brfA-3m63B:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		3 LYS A 121
LYS A  97
VAL A 123
 None
 1.01A 3brfA-3mtjA:
undetectable		 3brfA-3mtjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1

(Saccharomyces
cerevisiae) 		PF12539
(Csm1) 		3 LYS A 119
LYS A 139
VAL A 137
 None
 0.69A 3brfA-3n4xA:
undetectable		 3brfA-3n4xA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		3 LYS A  94
LYS A  88
VAL A  89
 None
 0.83A 3brfA-3ol2A:
undetectable		 3brfA-3ol2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LYS A 653
LYS A 624
VAL A 604
 None
 1.05A 3brfA-3psiA:
undetectable		 3brfA-3psiA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		3 LYS A  57
LYS A  51
VAL A  52
 None
 1.04A 3brfA-3rvaA:
undetectable		 3brfA-3rvaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwn GENE 9 PROTEIN

(Shigella virus
Sf6) 		PF16532
(Phage_tail_NK) 		3 LYS A 168
LYS A 187
VAL A 164
 None
 0.89A 3brfA-3rwnA:
undetectable		 3brfA-3rwnA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 LYS A 926
LYS A 952
VAL A 955
 None
 1.05A 3brfA-3s5kA:
undetectable		 3brfA-3s5kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u04 PEPTIDE DEFORMYLASE
1

(Ehrlichia
chaffeensis) 		PF01327
(Pep_deformylase) 		3 LYS A  56
LYS A  23
VAL A  21
 None
 0.81A 3brfA-3u04A:
undetectable		 3brfA-3u04A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		3 LYS A 149
LYS A  52
VAL A 152
 None
 1.08A 3brfA-3wdgA:
undetectable		 3brfA-3wdgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 LYS A 333
LYS A 343
VAL A 344
 None
 0.90A 3brfA-3wquA:
undetectable		 3brfA-3wquA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 LYS A 333
LYS A 343
VAL A 344
 None
 1.02A 3brfA-3wt0A:
undetectable		 3brfA-3wt0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 3 LYS A 239
LYS A 220
VAL A 223
 None
 1.09A 3brfA-3x1oA:
undetectable		 3brfA-3x1oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 LYS A 351
LYS A 357
VAL A 353
 None
 1.03A 3brfA-3zdpA:
undetectable		 3brfA-3zdpA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zle APICAL MEMBRANE
ANTIGEN 1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		3 LYS A 344
LYS A 315
VAL A 425
 None
 1.04A 3brfA-3zleA:
undetectable		 3brfA-3zleA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3q ALANINE RACEMASE 1

(Staphylococcus
aureus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 195
LYS A 187
VAL A 190
 None
 1.04A 3brfA-4a3qA:
undetectable		 3brfA-4a3qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 LYS C 507
LYS C 543
VAL C 538
 None
 0.85A 3brfA-4aq1C:
undetectable		 3brfA-4aq1C:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Toxoplasma
gondii) 		PF11539
(DUF3228) 		3 LYS A 214
LYS A 207
VAL A 210
 None
 1.01A 3brfA-4fbdA:
undetectable		 3brfA-4fbdA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		3 LYS A  28
LYS A  32
VAL A  31
 None
 1.10A 3brfA-4g4eA:
undetectable		 3brfA-4g4eA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		3 LYS A 556
LYS A 633
VAL A 634
 None
 1.11A 3brfA-4ifqA:
undetectable		 3brfA-4ifqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		3 LYS A 181
LYS A 308
VAL A 304
 None
 0.87A 3brfA-4j34A:
undetectable		 3brfA-4j34A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jtv HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS A 148
LYS A 136
VAL A 138
 SIA  A 605 (-3.3A)
None
None
 0.70A 3brfA-4jtvA:
undetectable		 3brfA-4jtvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 208
LYS H 120
VAL H 121
 None
 1.00A 3brfA-4k3dH:
2.3		 3brfA-4k3dH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 208
LYS H 120
VAL H 121
 None
 0.97A 3brfA-4k3eH:
2.8		 3brfA-4k3eH:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		3 LYS A 234
LYS A   0
VAL A  50
 None
 0.99A 3brfA-4k3fA:
undetectable		 3brfA-4k3fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 440
LYS A 434
VAL A 436
 None
 1.01A 3brfA-4lk2A:
undetectable		 3brfA-4lk2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 3 LYS A  69
LYS A 323
VAL A  65
 None
 0.99A 3brfA-4ofzA:
undetectable		 3brfA-4ofzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 LYS A 148
LYS A 141
VAL A 144
 None
 0.84A 3brfA-4pueA:
undetectable		 3brfA-4pueA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		3 LYS A 313
LYS A 253
VAL A 309
 None
 0.99A 3brfA-4q0mA:
undetectable		 3brfA-4q0mA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 LYS A  57
LYS A  51
VAL A  52
 None
 1.03A 3brfA-4qr8A:
undetectable		 3brfA-4qr8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		3 LYS A 239
LYS A 220
VAL A 223
 None
 1.07A 3brfA-4txaA:
undetectable		 3brfA-4txaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL33M,
MRPL33

(Sus scrofa) 		PF00471
(Ribosomal_L33) 		3 LYS 6  33
LYS 6  60
VAL 6  18
 None
 1.07A 3brfA-4v196:
undetectable		 3brfA-4v196:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wo7 FOLDASE PROTEIN PRSA

(Bacillus
subtilis) 		PF05698
(Trigger_C)
PF13616
(Rotamase_3) 		3 LYS A  87
LYS A  49
VAL A  50
 None
 0.96A 3brfA-4wo7A:
undetectable		 3brfA-4wo7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wo7 FOLDASE PROTEIN PRSA

(Bacillus
subtilis) 		PF05698
(Trigger_C)
PF13616
(Rotamase_3) 		3 LYS A 218
LYS A 101
VAL A 102
 None
 0.90A 3brfA-4wo7A:
undetectable		 3brfA-4wo7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsy RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		3 LYS F 299
LYS F 289
VAL F 292
 None
 0.87A 3brfA-4xsyF:
undetectable		 3brfA-4xsyF:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 LYS A 343
LYS A 372
VAL A 358
 None
 1.10A 3brfA-4zadA:
undetectable		 3brfA-4zadA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF02097
(Filo_VP35)
PF05505
(Ebola_NP) 		3 LYS A 281
LYS A 274
VAL A 277
 None
 1.04A 3brfA-4ztiA:
undetectable		 3brfA-4ztiA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 LYS A  57
LYS A  51
VAL A  52
 None
 1.10A 3brfA-4zwoA:
undetectable		 3brfA-4zwoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 LYS A 707
LYS A 697
VAL A 700
 None
 1.00A 3brfA-5b2oA:
undetectable		 3brfA-5b2oA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk3 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS B  12
LYS B  19
VAL B  18
 None
 1.07A 3brfA-5dk3B:
2.8		 3brfA-5dk3B:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 LYS E 132
LYS E 211
VAL E 237
 None
 0.99A 3brfA-5e24E:
44.6		 3brfA-5e24E:
55.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		3 LYS A 334
LYS A 367
VAL A 368
 None
 1.05A 3brfA-5ed1A:
undetectable		 3brfA-5ed1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 3 LYS C 305
LYS C 300
VAL C 303
 None
 0.91A 3brfA-5gp4C:
undetectable		 3brfA-5gp4C:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 263
LYS H 175
VAL H 176
 None
 1.05A 3brfA-5ihuH:
2.8		 3brfA-5ihuH:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		3 LYS A4066
LYS A4061
VAL A4064
 None
 0.79A 3brfA-5ii5A:
undetectable		 3brfA-5ii5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		3 LYS B  89
LYS B  39
VAL B  36
 None
 1.02A 3brfA-5iklB:
undetectable		 3brfA-5iklB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		3 LYS A 205
LYS A 238
VAL A 202
 None
 0.66A 3brfA-5loeA:
undetectable		 3brfA-5loeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxl DECORATION PROTEIN

(Escherichia
virus T5) 		no annotation 3 LYS A  14
LYS A  55
VAL A  57
 None
 0.99A 3brfA-5lxlA:
undetectable		 3brfA-5lxlA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 LYS B 111
LYS B 276
VAL B 113
 None
 0.91A 3brfA-5lxzB:
undetectable		 3brfA-5lxzB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN

(Homo sapiens) 		no annotation 3 LYS H  12
LYS H  19
VAL H  18
 None
 1.10A 3brfA-5ngvH:
undetectable		 3brfA-5ngvH:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		3 LYS A  70
LYS A  66
VAL A  68
 None
 1.03A 3brfA-5tdgA:
undetectable		 3brfA-5tdgA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 LYS A  56
LYS A  49
VAL A  52
 None
 1.05A 3brfA-5tu0A:
undetectable		 3brfA-5tu0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uah RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		3 LYS F 299
LYS F 289
VAL F 292
 None
 0.75A 3brfA-5uahF:
undetectable		 3brfA-5uahF:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 LYS A  46
LYS A  39
VAL A  42
 None
 1.08A 3brfA-5ucdA:
undetectable		 3brfA-5ucdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 LYS G 487
LYS G  46
VAL G 489
 None
 1.02A 3brfA-5um8G:
undetectable		 3brfA-5um8G:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn8 B12 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 3 LYS H  12
LYS H  19
VAL H  18
 None
 0.97A 3brfA-5vn8H:
2.2		 3brfA-5vn8H:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 3 LYS G 487
LYS G  46
VAL G 489
 None
 0.85A 3brfA-5wduG:
undetectable		 3brfA-5wduG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 LYS A 554
LYS A 546
VAL A 549
 None
 1.06A 3brfA-5xblA:
undetectable		 3brfA-5xblA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7i CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Oreochromis
mossambicus) 		no annotation 3 LYS A  57
LYS A  19
VAL A  52
 None
 0.93A 3brfA-5y7iA:
undetectable		 3brfA-5y7iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 3 LYS A 349
LYS A 344
VAL A 346
 None
 0.83A 3brfA-5yjhA:
undetectable		 3brfA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrz HICA

(Streptococcus
pneumoniae) 		no annotation 3 LYS B  28
LYS B  15
VAL B  18
 None
 0.84A 3brfA-5yrzB:
undetectable		 3brfA-5yrzB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apd AM22 FAB HEAVY
CHAIN,IGH@ PROTEIN

(Homo sapiens) 		no annotation 3 LYS D  12
LYS D  19
VAL D  18
 None
 0.95A 3brfA-6apdD:
undetectable		 3brfA-6apdD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 3 LYS I  35
LYS I  19
VAL I  20
 None
 0.99A 3brfA-6esqI:
undetectable		 3brfA-6esqI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM

(Porphyromonas
gingivalis) 		no annotation 3 LYS A 426
LYS A 489
VAL A 515
 None
 1.10A 3brfA-6ey5A:
undetectable		 3brfA-6ey5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2

(Homo sapiens) 		no annotation 3 LYS j  55
LYS j 285
VAL j 288
 None
 0.88A 3brfA-6f1yj:
undetectable		 3brfA-6f1yj:
undetectable