SIMILAR PATTERNS OF AMINO ACIDS FOR 3BRF_A_SORA1_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		3 GLY E 217
ASP E 303
SER E  12
 None
 0.55A 3brfA-1cziE:
undetectable		 3brfA-1cziE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 GLY B  24
ASP B  25
SER B 561
 None
 0.70A 3brfA-1e9yB:
0.0		 3brfA-1e9yB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		3 GLY A 232
ASP A 234
SER A 235
 None
 0.66A 3brfA-1fpsA:
undetectable		 3brfA-1fpsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		3 GLY L 292
ASP L 150
SER L 289
 None
 0.71A 3brfA-1hfeL:
0.0		 3brfA-1hfeL:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 GLY A 292
ASP A 156
SER A 157
 None
MG  A 401 ( 4.3A)
None
 0.56A 3brfA-1inpA:
undetectable		 3brfA-1inpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 GLY A 113
ASP A 177
SER A 148
 None
 0.68A 3brfA-1itkA:
undetectable		 3brfA-1itkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 GLY A 106
ASP A  48
SER A  49
 None
CA  A 351 (-3.2A)
None
 0.72A 3brfA-1llpA:
undetectable		 3brfA-1llpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 GLY A 118
ASP A  37
SER A  35
 None
 0.69A 3brfA-1ofeA:
0.0		 3brfA-1ofeA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 181
ASP A 203
SER A 205
 NAD  A 400 (-3.2A)
NAD  A 400 (-2.6A)
None
 0.63A 3brfA-1pl8A:
undetectable		 3brfA-1pl8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		3 GLY A  14
ASP A  27
SER A  40
 None
 0.65A 3brfA-1pojA:
undetectable		 3brfA-1pojA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		3 GLY A 269
ASP A 273
SER A 350
 None
 0.66A 3brfA-1qfxA:
undetectable		 3brfA-1qfxA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 GLY A 128
ASP A 151
SER A 156
 FAD  A 605 (-3.0A)
FAD  A 605 (-2.8A)
None
 0.69A 3brfA-1qo8A:
undetectable		 3brfA-1qo8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		3 GLY A 131
ASP A 151
SER A 153
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.9A)
None
 0.58A 3brfA-1sg9A:
undetectable		 3brfA-1sg9A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siq GLUTARYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLY A 310
ASP A 314
SER A  75
 None
 0.65A 3brfA-1siqA:
undetectable		 3brfA-1siqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		3 GLY A 143
ASP A  61
SER A  60
 None
 0.71A 3brfA-1t5eA:
undetectable		 3brfA-1t5eA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 GLY A 230
ASP A 334
SER A 335
 None
 0.19A 3brfA-1ttuA:
50.4		 3brfA-1ttuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 GLY A  48
ASP A  67
SER A  69
 SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-4.7A)
 0.71A 3brfA-1ve3A:
undetectable		 3brfA-1ve3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 GLY A  74
ASP A 148
SER A 150
 NAD  A 601 (-3.3A)
NAD  A 601 (-2.7A)
None
 0.41A 3brfA-1vkoA:
undetectable		 3brfA-1vkoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 GLY A 175
ASP A 173
SER A 218
 None
 0.65A 3brfA-1yniA:
undetectable		 3brfA-1yniA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bps YUKD PROTEIN

(Bacillus
subtilis) 		PF08817
(YukD) 		3 GLY A   0
ASP A  23
SER A  66
 None
 0.65A 3brfA-2bpsA:
undetectable		 3brfA-2bpsA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 GLY A 136
ASP A 139
SER A 140
 None
 0.66A 3brfA-2d2iA:
undetectable		 3brfA-2d2iA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		3 GLY A 139
ASP A 129
SER A 128
 None
 0.61A 3brfA-2f9tA:
undetectable		 3brfA-2f9tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		3 GLY A 183
ASP A 187
SER A 227
 None
 0.68A 3brfA-2grmA:
undetectable		 3brfA-2grmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 GLY A  33
ASP A  30
SER A 183
 None
 0.65A 3brfA-2h2qA:
undetectable		 3brfA-2h2qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxm VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VTA1 HOMOLOG

(Homo sapiens) 		PF04652
(Vta1) 		3 GLY A  46
ASP A  50
SER A  51
 None
 0.62A 3brfA-2lxmA:
undetectable		 3brfA-2lxmA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		3 GLY A  48
ASP A  71
SER A  72
 CA  A 205 (-4.1A)
CA  A 205 (-3.2A)
None
 0.66A 3brfA-2ml3A:
undetectable		 3brfA-2ml3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1b GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		3 GLY A  20
ASP A  91
SER A  94
 None
 0.67A 3brfA-2n1bA:
undetectable		 3brfA-2n1bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n47 SLR1183 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13649
(Methyltransf_25) 		3 GLY A  39
ASP A  58
SER A  60
 None
 0.70A 3brfA-2n47A:
undetectable		 3brfA-2n47A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 GLY A 107
ASP A  47
SER A  48
 None
 0.72A 3brfA-2okxA:
undetectable		 3brfA-2okxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		3 GLY A 206
ASP A 227
SER A 229
 None
 0.54A 3brfA-2pjdA:
undetectable		 3brfA-2pjdA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		3 GLY A  12
ASP A  34
SER A  36
 None
 0.63A 3brfA-2pn1A:
undetectable		 3brfA-2pn1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 GLY A  68
ASP A  88
SER A  90
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
None
 0.62A 3brfA-2pxxA:
undetectable		 3brfA-2pxxA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLY A 801
ASP A 799
SER A 794
 None
 0.61A 3brfA-2qf7A:
undetectable		 3brfA-2qf7A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 GLY A 125
ASP A 123
SER A 282
 None
 0.56A 3brfA-2qtkA:
undetectable		 3brfA-2qtkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		3 GLY A 309
ASP A 307
SER A 392
 None
 0.68A 3brfA-2qvwA:
undetectable		 3brfA-2qvwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2taa TAKA-AMYLASE A

(Aspergillus
oryzae) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 GLY A 470
ASP A 476
SER A 478
 None
 0.60A 3brfA-2taaA:
undetectable		 3brfA-2taaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 GLY A 885
ASP A 882
SER A 872
 None
 0.67A 3brfA-2vxrA:
7.1		 3brfA-2vxrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN
COMPLEMENT FACTOR B

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		3 GLY F 371
ASP B1520
SER B1586
 None
 0.69A 3brfA-2xwbF:
undetectable		 3brfA-2xwbF:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn3 PUTATIVE INNER
MEMBRANE PROTEIN

(Salmonella
enterica) 		PF12245
(Big_3_2) 		3 GLY A5137
ASP A5196
SER A5195
 CA  A6362 ( 4.4A)
CA  A6362 (-2.9A)
None
 0.71A 3brfA-2yn3A:
3.1		 3brfA-2yn3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		3 GLY A  37
ASP A  13
SER A 286
 None
 0.67A 3brfA-2z2bA:
undetectable		 3brfA-2z2bA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 GLY A 136
ASP A 139
SER A 140
 None
 0.47A 3brfA-3b20A:
undetectable		 3brfA-3b20A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by7 UNCHARACTERIZED
PROTEIN

(uncultured
marine organism) 		no annotation 3 GLY A  24
ASP A  65
SER A  66
 None
 0.60A 3brfA-3by7A:
undetectable		 3brfA-3by7A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		3 GLY A 231
ASP A 210
SER A 211
 NA  A 324 ( 4.1A)
NA  A 324 ( 4.7A)
NA  A 324 ( 4.8A)
 0.66A 3brfA-3c17A:
undetectable		 3brfA-3c17A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		3 GLY A  97
ASP A 101
SER A 132
 None
 0.59A 3brfA-3ce9A:
undetectable		 3brfA-3ce9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		3 GLY A 125
ASP A 101
SER A 132
 None
 0.67A 3brfA-3ce9A:
undetectable		 3brfA-3ce9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		3 GLY A 316
ASP A 319
SER A 320
 None
 0.58A 3brfA-3dafA:
undetectable		 3brfA-3dafA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		3 GLY A 212
ASP A  41
SER A  43
 None
 0.66A 3brfA-3dulA:
undetectable		 3brfA-3dulA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		3 GLY A  53
ASP A  72
SER A  74
 SAM  A 221 (-3.2A)
SAM  A 221 (-2.8A)
SAM  A 221 (-4.6A)
 0.69A 3brfA-3e23A:
undetectable		 3brfA-3e23A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		3 GLY A  62
ASP A 125
SER A  96
 None
 0.71A 3brfA-3e2nA:
undetectable		 3brfA-3e2nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		3 GLY A  86
ASP A  83
SER A 338
 None
 0.71A 3brfA-3ec1A:
undetectable		 3brfA-3ec1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		3 GLY A  35
ASP A  37
SER A   5
 None
 0.48A 3brfA-3fluA:
undetectable		 3brfA-3fluA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		3 GLY A  65
ASP A  84
SER A  86
 SAH  A 248 (-3.2A)
SAH  A 248 (-2.9A)
None
 0.70A 3brfA-3ggdA:
undetectable		 3brfA-3ggdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		3 GLY A 186
ASP A 206
SER A 208
 None
GOL  A 322 (-3.5A)
None
 0.57A 3brfA-3grzA:
undetectable		 3brfA-3grzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		3 GLY A 723
ASP A 745
SER A 747
 SAH  A 951 (-3.7A)
SAH  A 951 (-2.8A)
U  C   1 (-2.6A)
 0.59A 3brfA-3htxA:
undetectable		 3brfA-3htxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		3 GLY A 405
ASP A 403
SER A 426
 None
 0.72A 3brfA-3i6sA:
undetectable		 3brfA-3i6sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j15 PROTEIN PELOTA

(Pyrococcus
furiosus) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 GLY A 238
ASP A 147
SER A 161
 None
 0.52A 3brfA-3j15A:
undetectable		 3brfA-3j15A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		3 GLY A 153
ASP A 151
SER A 310
 None
 0.59A 3brfA-3jtyA:
undetectable		 3brfA-3jtyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		3 GLY A 290
ASP A 311
SER A 313
 None
 0.70A 3brfA-3jwjA:
undetectable		 3brfA-3jwjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jze DIHYDROOROTASE

(Salmonella
enterica) 		PF01979
(Amidohydro_1) 		3 GLY A  38
ASP A  14
SER A 297
 None
 0.67A 3brfA-3jzeA:
undetectable		 3brfA-3jzeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  77
ASP A  56
SER A  55
 None
None
ZN  A 401 (-4.5A)
 0.71A 3brfA-3m6iA:
undetectable		 3brfA-3m6iA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 GLY G 885
ASP G 882
SER G 872
 None
 0.64A 3brfA-3mppG:
7.1		 3brfA-3mppG:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLY A 152
ASP A 148
SER A  30
 None
 0.63A 3brfA-3mruA:
undetectable		 3brfA-3mruA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 3 GLY A 235
ASP A 230
SER A 198
 None
None
GOL  A   5 (-3.5A)
 0.70A 3brfA-3n6zA:
undetectable		 3brfA-3n6zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7k BOTULINUM NEUROTOXIN
TYPE C1

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 GLY A 888
ASP A 885
SER A 875
 None
 0.52A 3brfA-3n7kA:
7.3		 3brfA-3n7kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		3 GLY A 510
ASP A 391
SER A 390
 None
 0.72A 3brfA-3no8A:
undetectable		 3brfA-3no8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		3 GLY A 392
ASP A 368
SER A 365
 None
 0.71A 3brfA-3o82A:
undetectable		 3brfA-3o82A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogg BOTULINUM NEUROTOXIN
TYPE D

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 GLY A 884
ASP A 881
SER A 871
 None
 0.60A 3brfA-3oggA:
7.8		 3brfA-3oggA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE

(Staphylococcus
aureus) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		3 GLY A  18
ASP A  39
SER A  41
 None
 0.67A 3brfA-3orqA:
undetectable		 3brfA-3orqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		3 GLY A  56
ASP A  75
SER A  77
 SAM  A 300 (-3.1A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.5A)
 0.67A 3brfA-3ou6A:
undetectable		 3brfA-3ou6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		3 GLY A  42
ASP A  64
SER A  66
 NAD  A 501 (-3.1A)
NAD  A 501 (-2.6A)
None
 0.34A 3brfA-3pvzA:
undetectable		 3brfA-3pvzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 180
ASP A 202
SER A 204
 None
 0.63A 3brfA-3qe3A:
undetectable		 3brfA-3qe3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 GLY A 158
ASP A 222
SER A 193
 None
 0.67A 3brfA-3ut2A:
undetectable		 3brfA-3ut2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 GLY A 112
ASP A 176
SER A 147
 None
 0.66A 3brfA-3wxoA:
undetectable		 3brfA-3wxoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 3 GLY A  14
ASP A  34
SER A  36
 GDP  A 999 (-3.3A)
GDP  A 999 ( 4.4A)
None
 0.59A 3brfA-3zbqA:
undetectable		 3brfA-3zbqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 GLY A 106
ASP A 102
SER A  30
 None
 0.51A 3brfA-4af1A:
undetectable		 3brfA-4af1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		3 GLY A 125
ASP A 189
SER A 160
 None
 0.63A 3brfA-4c51A:
undetectable		 3brfA-4c51A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		3 GLY A  51
ASP A 125
SER A  96
 None
 0.67A 3brfA-4cuoA:
undetectable		 3brfA-4cuoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		3 GLY A 238
ASP A 259
SER A 261
 SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
None
 0.66A 3brfA-4dcmA:
undetectable		 3brfA-4dcmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		3 GLY A  72
ASP A  69
SER A  30
 None
 0.63A 3brfA-4e9kA:
undetectable		 3brfA-4e9kA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2e CUPA

(Streptococcus
pneumoniae) 		PF13473
(Cupredoxin_1) 		3 GLY A  47
ASP A  70
SER A  72
 None
 0.71A 3brfA-4f2eA:
undetectable		 3brfA-4f2eA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 GLY A 796
ASP A 799
SER A 800
 None
 0.51A 3brfA-4fm9A:
undetectable		 3brfA-4fm9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fms PROBABLE PORIN

(Pseudomonas
aeruginosa) 		no annotation 3 GLY B 128
ASP B 126
SER B 285
 BDP  B 401 ( 4.4A)
BDP  B 401 (-2.8A)
BDP  B 401 (-3.3A)
 0.61A 3brfA-4fmsB:
undetectable		 3brfA-4fmsB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 GLY A 884
ASP A 881
SER A 871
 None
 0.59A 3brfA-4fvvA:
7.2		 3brfA-4fvvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		3 GLY A 103
ASP A 109
SER A 108
 None
None
ADP  A 401 (-2.4A)
 0.71A 3brfA-4gyiA:
undetectable		 3brfA-4gyiA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		3 GLY A 134
ASP A 156
SER A 158
 NAD  A 301 (-3.2A)
NAD  A 301 (-2.7A)
None
 0.67A 3brfA-4k28A:
undetectable		 3brfA-4k28A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 GLY A 201
ASP A 211
SER A 210
 None
 0.68A 3brfA-4k3bA:
undetectable		 3brfA-4k3bA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 GLY A 109
ASP A 617
SER A 616
 None
 0.70A 3brfA-4kcaA:
undetectable		 3brfA-4kcaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		3 GLY A 230
ASP A 250
SER A 252
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-4.7A)
 0.70A 3brfA-4kriA:
undetectable		 3brfA-4kriA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		3 GLY A  69
ASP A 139
SER A 136
 None
 0.67A 3brfA-4m0dA:
undetectable		 3brfA-4m0dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 GLY A 345
ASP A 317
SER A 314
 None
 0.63A 3brfA-4mivA:
undetectable		 3brfA-4mivA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		3 GLY A 198
ASP A 241
SER A 243
 None
 0.55A 3brfA-4n06A:
undetectable		 3brfA-4n06A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		3 GLY A  53
ASP A  57
SER A  58
 None
 0.65A 3brfA-4nf7A:
undetectable		 3brfA-4nf7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE

(Drosophila
melanogaster) 		PF05822
(UMPH-1) 		3 GLY A 173
ASP A  57
SER A  73
 MG7  A 403 (-3.5A)
MG7  A 403 (-3.9A)
MG7  A 403 ( 4.6A)
 0.63A 3brfA-4nv0A:
undetectable		 3brfA-4nv0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		3 GLY A 198
ASP A  78
SER A  93
 ASP  A 402 ( 3.9A)
None
None
 0.39A 3brfA-4o48A:
undetectable		 3brfA-4o48A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		3 GLY A 199
ASP A 181
SER A 182
 None
 0.68A 3brfA-4o6vA:
undetectable		 3brfA-4o6vA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		3 GLY A  77
ASP A  44
SER A  41
 None
 0.64A 3brfA-4ofxA:
undetectable		 3brfA-4ofxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 3 GLY B  78
ASP B 198
SER B 204
 ADE  B 301 (-3.2A)
ADE  B 301 (-2.4A)
ADE  B 301 ( 3.8A)
 0.72A 3brfA-4qezB:
undetectable		 3brfA-4qezB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufq HYALURONIDASE

(Streptomyces
koganeiensis) 		PF07212
(Hyaluronidase_1) 		3 GLY A  84
ASP A  90
SER A  89
 None
 0.61A 3brfA-4ufqA:
undetectable		 3brfA-4ufqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		3 GLY A 363
ASP A 341
SER A 338
 None
 0.61A 3brfA-4ug4A:
undetectable		 3brfA-4ug4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usc PEROXIDASE

(Trachycarpus
fortunei) 		PF00141
(peroxidase) 		3 GLY A  51
ASP A 125
SER A  96
 None
 0.71A 3brfA-4uscA:
undetectable		 3brfA-4uscA:
20.81