SIMILAR PATTERNS OF AMINO ACIDS FOR 3BOG_D_DHID8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 SER A  13
GLY A  14
GLY A 285
GLY A 160
 FAD  A 395 (-3.0A)
None
FAD  A 395 (-3.5A)
FAD  A 395 (-3.5A)
 0.91A 3bogB-1cj2A:
0.0
3bogD-1cj2A:
0.0		 3bogB-1cj2A:
undetectable
3bogD-1cj2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 SER A 265
GLY A 264
GLY A 239
GLY A 190
 None
 0.79A 3bogB-1kb0A:
0.0
3bogD-1kb0A:
0.0		 3bogB-1kb0A:
undetectable
3bogD-1kb0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 SER A 225
GLY A  47
GLY A 221
GLY A 181
 None
 0.74A 3bogB-1kplA:
0.0
3bogD-1kplA:
0.0		 3bogB-1kplA:
undetectable
3bogD-1kplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psw ADP-HEPTOSE LPS
HEPTOSYLTRANSFERASE
II

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 SER A 270
GLY A 271
GLY A 188
GLY A 220
 None
 0.67A 3bogB-1pswA:
undetectable
3bogD-1pswA:
0.0		 3bogB-1pswA:
undetectable
3bogD-1pswA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 SER A 150
GLY A 151
GLY A 212
GLY A 231
 None
 0.84A 3bogB-1sfrA:
0.0
3bogD-1sfrA:
0.0		 3bogB-1sfrA:
undetectable
3bogD-1sfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfj PUTATIVE
ELICITOR-RESPONSIVE
GENE

(Arabidopsis
thaliana) 		PF00168
(C2) 		4 SER A   5
GLY A   4
GLY A   7
GLY A  69
 None
 0.76A 3bogB-1wfjA:
0.0
3bogD-1wfjA:
0.0		 3bogB-1wfjA:
undetectable
3bogD-1wfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 SER A 202
GLY A 203
GLY A 199
GLY A 194
 None
 0.83A 3bogB-1xf1A:
0.0
3bogD-1xf1A:
0.0		 3bogB-1xf1A:
undetectable
3bogD-1xf1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 SER A 133
GLY A 132
GLY A 148
GLY A 155
 None
 0.84A 3bogB-1zc6A:
0.0
3bogD-1zc6A:
0.0		 3bogB-1zc6A:
undetectable
3bogD-1zc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 241
GLY A 240
GLY A 145
GLY A 117
 None
 0.90A 3bogB-1zxoA:
undetectable
3bogD-1zxoA:
0.0		 3bogB-1zxoA:
undetectable
3bogD-1zxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 SER A 242
GLY A 241
GLY A 180
GLY A 132
 None
 0.87A 3bogB-2aa4A:
undetectable
3bogD-2aa4A:
undetectable		 3bogB-2aa4A:
undetectable
3bogD-2aa4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 SER B 336
GLY B 337
GLY B 250
GLY B 248
 None
 0.78A 3bogB-2afhB:
undetectable
3bogD-2afhB:
undetectable		 3bogB-2afhB:
undetectable
3bogD-2afhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		4 SER A 129
GLY A 128
GLY A 144
GLY A 151
 None
GLC  A1001 (-3.6A)
None
None
 0.74A 3bogB-2ch6A:
undetectable
3bogD-2ch6A:
undetectable		 3bogB-2ch6A:
undetectable
3bogD-2ch6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER C  21
GLY C 126
GLY C  19
GLY C 248
 None
 0.76A 3bogB-2d3tC:
undetectable
3bogD-2d3tC:
undetectable		 3bogB-2d3tC:
undetectable
3bogD-2d3tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgx KIAA0430 PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 SER A 550
GLY A 549
GLY A 552
GLY A 634
 None
 0.83A 3bogB-2dgxA:
undetectable
3bogD-2dgxA:
undetectable		 3bogB-2dgxA:
undetectable
3bogD-2dgxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djr ZINC FINGER BED
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02892
(zf-BED) 		4 SER A  71
GLY A  72
GLY A   7
GLY A  47
 None
 0.84A 3bogB-2djrA:
undetectable
3bogD-2djrA:
undetectable		 3bogB-2djrA:
undetectable
3bogD-2djrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT

(Homo sapiens) 		PF00620
(RhoGAP) 		4 SER A   2
GLY A   1
GLY A   4
GLY A  14
 None
 0.73A 3bogB-2ee4A:
undetectable
3bogD-2ee4A:
undetectable		 3bogB-2ee4A:
undetectable
3bogD-2ee4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 SER X 429
GLY X 428
GLY X 431
GLY X 419
 None
 0.86A 3bogB-2f2lX:
undetectable
3bogD-2f2lX:
undetectable		 3bogB-2f2lX:
undetectable
3bogD-2f2lX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		4 SER A 227
GLY A 226
GLY A  99
GLY A 101
 None
 0.81A 3bogB-2hykA:
undetectable
3bogD-2hykA:
undetectable		 3bogB-2hykA:
undetectable
3bogD-2hykA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7n PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE-LIKE 1

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 SER A 182
GLY A 181
GLY A 172
GLY A 177
 None
 0.88A 3bogB-2k7nA:
undetectable
3bogD-2k7nA:
undetectable		 3bogB-2k7nA:
undetectable
3bogD-2k7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		4 SER A 294
GLY A 251
GLY A  19
GLY A  70
 None
UNL  A 344 (-3.5A)
None
None
 0.90A 3bogB-2qe8A:
undetectable
3bogD-2qe8A:
undetectable		 3bogB-2qe8A:
undetectable
3bogD-2qe8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 SER A  26
GLY A  27
GLY A 136
GLY A  76
 None
 0.91A 3bogB-2qq1A:
undetectable
3bogD-2qq1A:
undetectable		 3bogB-2qq1A:
undetectable
3bogD-2qq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 SER A  86
GLY A 300
GLY A 142
GLY A 306
 None
 0.82A 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable		 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 SER A 225
GLY A  47
GLY A 221
GLY A 181
 None
 0.57A 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable		 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 SER G 803
GLY G 802
GLY G1056
GLY G 739
 FMN  G3051 (-2.8A)
FMN  G3051 (-3.5A)
FMN  G3051 ( 4.1A)
FMN  G3051 ( 4.3A)
 0.92A 3bogB-2uv8G:
undetectable
3bogD-2uv8G:
undetectable		 3bogB-2uv8G:
undetectable
3bogD-2uv8G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 SER A  16
GLY A  17
GLY A 305
GLY A 150
 FAD  A1395 (-2.6A)
None
FAD  A1395 (-3.5A)
FAD  A1395 (-3.3A)
 0.92A 3bogB-2vouA:
undetectable
3bogD-2vouA:
undetectable		 3bogB-2vouA:
undetectable
3bogD-2vouA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 169
GLY A 173
GLY A 148
GLY A 164
 None
None
None
FAD  A 601 ( 3.8A)
 0.78A 3bogB-2wdwA:
undetectable
3bogD-2wdwA:
undetectable		 3bogB-2wdwA:
undetectable
3bogD-2wdwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 140
GLY A 144
GLY A 119
GLY A 135
 None
None
None
FAD  A 600 ( 3.8A)
 0.85A 3bogB-2y3sA:
undetectable
3bogD-2y3sA:
undetectable		 3bogB-2y3sA:
undetectable
3bogD-2y3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 SER A 161
GLY A 162
GLY A 233
GLY A 254
 None
NDP  A 900 ( 4.8A)
None
NDP  A 900 (-3.4A)
 0.72A 3bogB-2zb3A:
undetectable
3bogD-2zb3A:
undetectable		 3bogB-2zb3A:
undetectable
3bogD-2zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 SER A 161
GLY A 162
GLY A 233
GLY A 254
 None
NAP  A 500 ( 4.7A)
None
NAP  A 500 (-3.1A)
 0.73A 3bogB-2zb4A:
undetectable
3bogD-2zb4A:
undetectable		 3bogB-2zb4A:
undetectable
3bogD-2zb4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 SER A 825
GLY A 824
GLY A 544
GLY A 792
 None
 0.71A 3bogB-2zxqA:
undetectable
3bogD-2zxqA:
undetectable		 3bogB-2zxqA:
undetectable
3bogD-2zxqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 SER A1169
GLY A1171
GLY A1242
GLY A1142
 None
 0.85A 3bogB-2zxqA:
undetectable
3bogD-2zxqA:
undetectable		 3bogB-2zxqA:
undetectable
3bogD-2zxqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER A 349
GLY A 350
GLY A 310
GLY A 332
 None
 0.77A 3bogB-3acpA:
undetectable
3bogD-3acpA:
undetectable		 3bogB-3acpA:
undetectable
3bogD-3acpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		4 SER A 184
GLY A 295
GLY A 154
GLY A 233
 None
None
SO4  A 345 (-3.4A)
None
 0.90A 3bogB-3cerA:
undetectable
3bogD-3cerA:
undetectable		 3bogB-3cerA:
undetectable
3bogD-3cerA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 SER A  48
GLY A 124
GLY A 203
GLY A 244
 None
 0.92A 3bogB-3cj1A:
undetectable
3bogD-3cj1A:
undetectable		 3bogB-3cj1A:
undetectable
3bogD-3cj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		4 SER A 456
GLY A 473
GLY A 389
GLY A 409
 None
 0.90A 3bogB-3edyA:
undetectable
3bogD-3edyA:
undetectable		 3bogB-3edyA:
undetectable
3bogD-3edyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 SER A 329
GLY A 328
GLY A  65
GLY A  63
 None
 0.72A 3bogB-3eh7A:
undetectable
3bogD-3eh7A:
undetectable		 3bogB-3eh7A:
undetectable
3bogD-3eh7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		4 SER A  85
GLY A  86
GLY A 216
GLY A 213
 None
 0.81A 3bogB-3fbqA:
undetectable
3bogD-3fbqA:
undetectable		 3bogB-3fbqA:
undetectable
3bogD-3fbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 SER A 277
GLY A 278
GLY A 290
GLY A 313
 None
None
AHZ  A1100 (-3.5A)
None
 0.93A 3bogB-3fpzA:
undetectable
3bogD-3fpzA:
undetectable		 3bogB-3fpzA:
undetectable
3bogD-3fpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A  17
GLY A 122
GLY A  15
GLY A 244
 None
 0.76A 3bogB-3goaA:
undetectable
3bogD-3goaA:
undetectable		 3bogB-3goaA:
undetectable
3bogD-3goaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		4 SER 4 359
GLY 4 340
GLY 4 362
GLY 5 191
 None
 0.72A 3bogB-3i9v4:
undetectable
3bogD-3i9v4:
undetectable		 3bogB-3i9v4:
undetectable
3bogD-3i9v4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 SER A 250
GLY A 249
GLY A 189
GLY A 219
 SER  A 250 ( 0.0A)
GLY  A 249 ( 0.0A)
GLY  A 189 (-0.0A)
GLY  A 219 ( 0.0A)
 0.82A 3bogB-3iccA:
undetectable
3bogD-3iccA:
undetectable		 3bogB-3iccA:
undetectable
3bogD-3iccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 SER A 289
GLY A 290
GLY A 246
GLY A 250
 None
 0.92A 3bogB-3mkqA:
undetectable
3bogD-3mkqA:
undetectable		 3bogB-3mkqA:
undetectable
3bogD-3mkqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER A 418
GLY A 417
GLY A 306
GLY A 234
 None
 0.89A 3bogB-3o80A:
undetectable
3bogD-3o80A:
undetectable		 3bogB-3o80A:
undetectable
3bogD-3o80A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 SER A  33
GLY A  34
GLY A 838
GLY A 808
 PPV  A1002 (-3.1A)
PPV  A1002 (-3.1A)
PPV  A1002 (-4.2A)
PPV  A1002 ( 4.3A)
 0.82A 3bogB-3pihA:
undetectable
3bogD-3pihA:
undetectable		 3bogB-3pihA:
undetectable
3bogD-3pihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 SER A 645
GLY A 646
GLY A 651
GLY A 654
 None
 0.61A 3bogB-3slkA:
undetectable
3bogD-3slkA:
undetectable		 3bogB-3slkA:
undetectable
3bogD-3slkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		4 SER A 267
GLY A 268
GLY A 190
GLY A 221
 None
 0.90A 3bogB-3tovA:
undetectable
3bogD-3tovA:
undetectable		 3bogB-3tovA:
undetectable
3bogD-3tovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 SER A 256
GLY A 257
GLY A 139
GLY A 182
 None
 0.64A 3bogB-3u9lA:
undetectable
3bogD-3u9lA:
undetectable		 3bogB-3u9lA:
undetectable
3bogD-3u9lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 SER B 716
GLY B 717
GLY B 586
GLY B 588
 None
 0.70A 3bogB-3v65B:
undetectable
3bogD-3v65B:
undetectable		 3bogB-3v65B:
undetectable
3bogD-3v65B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 437
GLY A 439
GLY A 416
GLY A 382
 None
 0.90A 3bogB-3vi3A:
undetectable
3bogD-3vi3A:
undetectable		 3bogB-3vi3A:
undetectable
3bogD-3vi3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER A 404
GLY A 403
GLY A 288
GLY A 222
 SO4  A 501 (-2.7A)
SO4  A 501 (-3.3A)
None
None
 0.89A 3bogB-3w0lA:
undetectable
3bogD-3w0lA:
undetectable		 3bogB-3w0lA:
undetectable
3bogD-3w0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuy TRANSPORTER

(Neisseria
meningitidis) 		PF01758
(SBF) 		4 SER A 297
GLY A 298
GLY A 234
GLY A 262
 None
None
PTY  A1319 (-3.5A)
NA  A1311 ( 4.7A)
 0.76A 3bogB-3zuyA:
undetectable
3bogD-3zuyA:
undetectable		 3bogB-3zuyA:
undetectable
3bogD-3zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 SER A  57
GLY A 133
GLY A 214
GLY A 256
 CL  A 502 ( 3.2A)
CL  A 503 ( 3.7A)
CL  A 501 (-3.6A)
None
 0.89A 3bogB-3zx2A:
undetectable
3bogD-3zx2A:
undetectable		 3bogB-3zx2A:
undetectable
3bogD-3zx2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 SER A 154
GLY A 155
GLY A 225
GLY A 246
 None
NAP  A 400 ( 4.7A)
None
NAP  A 400 (-3.4A)
 0.72A 3bogB-4b7xA:
undetectable
3bogD-4b7xA:
undetectable		 3bogB-4b7xA:
undetectable
3bogD-4b7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 SER A 267
GLY A 268
GLY A 298
GLY A  77
 None
 0.79A 3bogB-4emyA:
undetectable
3bogD-4emyA:
undetectable		 3bogB-4emyA:
undetectable
3bogD-4emyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER A 415
GLY A 414
GLY A 299
GLY A 233
 0NZ  A1002 (-2.6A)
0NZ  A1002 (-3.1A)
None
BGC  A1001 ( 3.8A)
 0.89A 3bogB-4f9oA:
undetectable
3bogD-4f9oA:
undetectable		 3bogB-4f9oA:
undetectable
3bogD-4f9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 SER A 397
GLY A 396
GLY A 186
GLY A 163
 PO4  A 503 (-2.2A)
None
PO4  A 503 (-3.1A)
None
 0.84A 3bogB-4i6mA:
undetectable
3bogD-4i6mA:
undetectable		 3bogB-4i6mA:
undetectable
3bogD-4i6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 SER B 310
GLY B 315
GLY B 306
GLY B 362
 None
 0.89A 3bogB-4iu9B:
undetectable
3bogD-4iu9B:
undetectable		 3bogB-4iu9B:
undetectable
3bogD-4iu9B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 SER A 422
GLY A 421
GLY A 440
GLY A 454
 None
 0.81A 3bogB-4k3cA:
undetectable
3bogD-4k3cA:
undetectable		 3bogB-4k3cA:
undetectable
3bogD-4k3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 SER A  55
GLY A  54
GLY A  36
GLY A 102
 None
 0.81A 3bogB-4maaA:
undetectable
3bogD-4maaA:
undetectable		 3bogB-4maaA:
undetectable
3bogD-4maaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		4 SER B 475
GLY B 483
GLY B 477
GLY B 479
 None
 0.86A 3bogB-4mbgB:
undetectable
3bogD-4mbgB:
undetectable		 3bogB-4mbgB:
undetectable
3bogD-4mbgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 353
GLY A 352
GLY A 359
GLY A 349
 None
 0.85A 3bogB-4nenA:
undetectable
3bogD-4nenA:
undetectable		 3bogB-4nenA:
undetectable
3bogD-4nenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 4 SER M 316
GLY M 294
GLY M 298
GLY M 273
 None
 0.90A 3bogB-4nzrM:
undetectable
3bogD-4nzrM:
undetectable		 3bogB-4nzrM:
undetectable
3bogD-4nzrM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 SER A  91
GLY A  90
GLY A  24
GLY A  22
 None
 0.91A 3bogB-4p48A:
undetectable
3bogD-4p48A:
undetectable		 3bogB-4p48A:
undetectable
3bogD-4p48A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 4 SER A  30
GLY A  31
GLY A  59
GLY A  61
 None
 0.93A 3bogB-4rggA:
undetectable
3bogD-4rggA:
undetectable		 3bogB-4rggA:
undetectable
3bogD-4rggA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 SER A 189
GLY A 186
GLY A 312
GLY A  89
 None
 0.92A 3bogB-4u1rA:
undetectable
3bogD-4u1rA:
undetectable		 3bogB-4u1rA:
undetectable
3bogD-4u1rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 241
GLY A 242
GLY A 172
GLY A 181
 None
 0.88A 3bogB-4um8A:
undetectable
3bogD-4um8A:
undetectable		 3bogB-4um8A:
undetectable
3bogD-4um8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		4 SER A 437
GLY A 439
GLY A 416
GLY A 382
 None
 0.87A 3bogB-4wk4A:
undetectable
3bogD-4wk4A:
undetectable		 3bogB-4wk4A:
undetectable
3bogD-4wk4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 SER A 616
GLY A 641
GLY A 194
GLY A 120
 None
 0.90A 3bogB-4zgvA:
undetectable
3bogD-4zgvA:
undetectable		 3bogB-4zgvA:
undetectable
3bogD-4zgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 SER A 221
GLY A 220
GLY A 223
GLY A 307
 None
 0.85A 3bogB-5bp8A:
undetectable
3bogD-5bp8A:
undetectable		 3bogB-5bp8A:
undetectable
3bogD-5bp8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 SER A 396
GLY A 406
GLY A 162
GLY A 187
 None
 0.84A 3bogB-5c2cA:
undetectable
3bogD-5c2cA:
undetectable		 3bogB-5c2cA:
undetectable
3bogD-5c2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 SER I 129
GLY I 130
GLY I 168
GLY I 170
 7F1  I 300 (-4.0A)
None
None
None
 0.91A 3bogB-5fmgI:
undetectable
3bogD-5fmgI:
undetectable		 3bogB-5fmgI:
undetectable
3bogD-5fmgI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 SER A 326
GLY A 325
GLY A 108
GLY A 106
 None
None
None
ACY  A 402 ( 4.1A)
 0.80A 3bogB-5hcfA:
undetectable
3bogD-5hcfA:
undetectable		 3bogB-5hcfA:
undetectable
3bogD-5hcfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 142
GLY A 146
GLY A 121
GLY A 137
 None
None
None
FAD  A 601 (-3.6A)
 0.80A 3bogB-5i1wA:
undetectable
3bogD-5i1wA:
undetectable		 3bogB-5i1wA:
undetectable
3bogD-5i1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 SER B 186
GLY B 185
GLY B 148
GLY B 116
 None
 0.80A 3bogB-5iklB:
undetectable
3bogD-5iklB:
undetectable		 3bogB-5iklB:
undetectable
3bogD-5iklB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		4 SER A  13
GLY A  14
GLY A 314
GLY A 163
 FAD  A 502 (-2.8A)
None
FAD  A 502 ( 4.3A)
FAD  A 502 (-3.5A)
 0.90A 3bogB-5ipyA:
undetectable
3bogD-5ipyA:
undetectable		 3bogB-5ipyA:
undetectable
3bogD-5ipyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A  17
GLY A  16
GLY A 186
GLY A 188
 SO4  A 403 (-2.8A)
None
SO4  A 403 (-3.8A)
SO4  A 403 (-3.9A)
 0.92A 3bogB-5jw6A:
undetectable
3bogD-5jw6A:
undetectable		 3bogB-5jw6A:
undetectable
3bogD-5jw6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 SER A 274
GLY A 277
GLY A 309
GLY A 280
 None
 0.90A 3bogB-5jydA:
undetectable
3bogD-5jydA:
undetectable		 3bogB-5jydA:
undetectable
3bogD-5jydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		4 SER A 429
GLY A 428
GLY A 189
GLY A 378
 FAD  A1801 ( 3.9A)
None
None
None
 0.75A 3bogB-5laeA:
undetectable
3bogD-5laeA:
undetectable		 3bogB-5laeA:
undetectable
3bogD-5laeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 SER B 503
GLY B 504
GLY B 498
GLY B 463
 None
 0.86A 3bogB-5lxzB:
undetectable
3bogD-5lxzB:
undetectable		 3bogB-5lxzB:
undetectable
3bogD-5lxzB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 SER A 337
GLY A 336
GLY A 176
GLY A 180
 None
 0.93A 3bogB-5mhfA:
undetectable
3bogD-5mhfA:
undetectable		 3bogB-5mhfA:
undetectable
3bogD-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm8 SERINE PROTEASE SPLE

(Staphylococcus
aureus) 		no annotation 4 SER A 155
GLY A 156
GLY A 172
GLY A 185
 None
 0.80A 3bogB-5mm8A:
undetectable
3bogD-5mm8A:
undetectable		 3bogB-5mm8A:
undetectable
3bogD-5mm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 163
GLY A 219
GLY A 176
GLY A 174
 None
 0.88A 3bogB-5tf0A:
undetectable
3bogD-5tf0A:
undetectable		 3bogB-5tf0A:
undetectable
3bogD-5tf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 SER F  15
GLY F  90
GLY F 160
GLY F 210
 PO4  F 502 (-2.6A)
None
PO4  F 502 (-3.4A)
None
 0.89A 3bogB-5u7xF:
undetectable
3bogD-5u7xF:
undetectable		 3bogB-5u7xF:
undetectable
3bogD-5u7xF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 SER A 459
GLY A 458
GLY A 461
GLY A 463
 None
 0.79A 3bogB-5uakA:
undetectable
3bogD-5uakA:
undetectable		 3bogB-5uakA:
undetectable
3bogD-5uakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 SER A 201
GLY A 200
GLY A 204
GLY A 206
 None
 0.77A 3bogB-5ucmA:
undetectable
3bogD-5ucmA:
undetectable		 3bogB-5ucmA:
undetectable
3bogD-5ucmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		4 SER A 236
GLY A 237
GLY A 230
GLY A 185
 None
None
NO3  A 417 (-4.1A)
None
 0.88A 3bogB-5ufhA:
undetectable
3bogD-5ufhA:
undetectable		 3bogB-5ufhA:
undetectable
3bogD-5ufhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 SER B  89
GLY B  90
GLY B  58
GLY B  83
 None
 0.80A 3bogB-5vipB:
undetectable
3bogD-5vipB:
undetectable		 3bogB-5vipB:
undetectable
3bogD-5vipB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A  41
GLY A  40
GLY A  64
GLY A  37
 CSO  A  39 ( 4.5A)
CSO  A  39 ( 2.4A)
None
None
 0.90A 3bogB-5vm2A:
undetectable
3bogD-5vm2A:
undetectable		 3bogB-5vm2A:
undetectable
3bogD-5vm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D

(Vibrio cholerae) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		4 SER A 567
GLY A 338
GLY A 353
GLY A 356
 None
 0.81A 3bogB-5wq8A:
undetectable
3bogD-5wq8A:
undetectable		 3bogB-5wq8A:
undetectable
3bogD-5wq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 SER A  60
GLY A  59
GLY A  73
GLY A  71
 None
ZN  A1801 ( 4.4A)
None
None
 0.90A 3bogB-5xogA:
undetectable
3bogD-5xogA:
undetectable		 3bogB-5xogA:
undetectable
3bogD-5xogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 SER A 174
GLY A 173
GLY A 196
GLY A 200
 None
None
GOL  A 603 (-3.2A)
None
 0.84A 3bogB-5z5dA:
undetectable
3bogD-5z5dA:
undetectable		 3bogB-5z5dA:
undetectable
3bogD-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 SER A 156
GLY A 155
GLY A 159
GLY A 188
 None
None
DXP  A 301 (-3.6A)
None
 0.88A 3bogB-5z9yA:
undetectable
3bogD-5z9yA:
undetectable		 3bogB-5z9yA:
undetectable
3bogD-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 SER A 339
GLY A 338
GLY A 341
GLY A 334
 None
 0.93A 3bogB-6bdzA:
undetectable
3bogD-6bdzA:
undetectable		 3bogB-6bdzA:
undetectable
3bogD-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 472
GLY A 469
GLY A 476
GLY A 427
 None
 0.88A 3bogB-6c6lA:
undetectable
3bogD-6c6lA:
undetectable		 3bogB-6c6lA:
undetectable
3bogD-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 4 SER A  13
GLY A  14
GLY A 285
GLY A 160
 FAD  A 401 (-2.6A)
None
FAD  A 401 (-3.6A)
FAD  A 401 (-3.8A)
 0.88A 3bogB-6dllA:
undetectable
3bogD-6dllA:
undetectable		 3bogB-6dllA:
undetectable
3bogD-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 SER B 263
GLY B 262
GLY B 244
GLY B 224
 None
 0.91A 3bogB-6dnhB:
undetectable
3bogD-6dnhB:
undetectable		 3bogB-6dnhB:
undetectable
3bogD-6dnhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 SER A 725
GLY A 724
GLY A 727
GLY A1058
 None
 0.90A 3bogB-6egtA:
undetectable
3bogD-6egtA:
undetectable		 3bogB-6egtA:
undetectable
3bogD-6egtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 SER B 263
GLY B 262
GLY B 244
GLY B 242
 None
 0.91A 3bogB-6f9nB:
undetectable
3bogD-6f9nB:
undetectable		 3bogB-6f9nB:
undetectable
3bogD-6f9nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 SER A1070
GLY A1069
GLY A1072
GLY A1248
 None
 0.80A 3bogB-6fn1A:
undetectable
3bogD-6fn1A:
undetectable		 3bogB-6fn1A:
undetectable
3bogD-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 4 SER A 742
GLY A 741
GLY A 744
GLY A 746
 None
 0.86A 3bogB-6fq3A:
undetectable
3bogD-6fq3A:
undetectable		 3bogB-6fq3A:
undetectable
3bogD-6fq3A:
undetectable