SIMILAR PATTERNS OF AMINO ACIDS FOR 3BOG_C_DVAC59_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE

(Azotobacter
vinelandii) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLY A 118
GLY A 143
GLY A 116
 None
 0.39A 3bogC-1a8pA:
0.0		 3bogC-1a8pA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		3 GLY A 223
GLY A 249
GLY A 247
 None
 0.33A 3bogC-1agxA:
undetectable		 3bogC-1agxA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
0H8  A   1 (-3.4A)
None
 0.41A 3bogC-1au8A:
0.0		 3bogC-1au8A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF02222
(ATP-grasp) 		3 GLY A  31
GLY A  10
GLY A   8
 None
 0.40A 3bogC-1b6rA:
0.0		 3bogC-1b6rA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 GLY A 462
GLY A 438
GLY A 440
 None
 0.40A 3bogC-1clwA:
0.2		 3bogC-1clwA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.38A 3bogC-1eufA:
0.0		 3bogC-1eufA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		3 GLY A  69
GLY A  64
GLY A  66
 None
 0.35A 3bogC-1evsA:
0.0		 3bogC-1evsA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLY A 489
GLY A 465
GLY A 463
 None
 0.34A 3bogC-1f4hA:
0.0		 3bogC-1f4hA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.29A 3bogC-1fi8A:
0.0		 3bogC-1fi8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.34A 3bogC-1fiwA:
undetectable		 3bogC-1fiwA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.37A 3bogC-1fizA:
undetectable		 3bogC-1fizA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 GLY A 322
GLY A 316
GLY A 318
 None
 0.39A 3bogC-1fn9A:
undetectable		 3bogC-1fn9A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLY A 374
GLY A 201
GLY A 199
 None
 0.35A 3bogC-1fnoA:
undetectable		 3bogC-1fnoA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.38A 3bogC-1fujA:
undetectable		 3bogC-1fujA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
0G6  A   1 (-3.7A)
None
 0.38A 3bogC-1fxyA:
undetectable		 3bogC-1fxyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		3 GLY A  29
GLY A  47
GLY A  49
 None
 0.32A 3bogC-1ghsA:
undetectable		 3bogC-1ghsA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 GLY A 322
GLY A 269
GLY A 271
 None
 0.17A 3bogC-1gytA:
undetectable		 3bogC-1gytA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		3 GLY A 225
GLY A 251
GLY A 249
 None
 0.40A 3bogC-1hg0A:
undetectable		 3bogC-1hg0A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 GLY A1296
GLY A1367
GLY A1365
 None
 0.41A 3bogC-1ihmA:
undetectable		 3bogC-1ihmA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLY A  12
GLY A   7
GLY A  10
 None
 0.40A 3bogC-1j6uA:
undetectable		 3bogC-1j6uA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		3 GLY A 140
GLY A 135
GLY A 138
 None
 0.41A 3bogC-1js6A:
undetectable		 3bogC-1js6A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		3 GLY H  80
GLY H  48
GLY H  84
 None
 0.33A 3bogC-1ka9H:
undetectable		 3bogC-1ka9H:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		3 GLY A 268
GLY A 273
GLY A 271
 None
 0.40A 3bogC-1kp2A:
undetectable		 3bogC-1kp2A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		3 GLY A 300
GLY A 142
GLY A 303
 None
 0.38A 3bogC-1kplA:
undetectable		 3bogC-1kplA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLY A 221
GLY A 246
GLY A 219
 None
None
SO4  A 402 (-3.5A)
 0.37A 3bogC-1krhA:
undetectable		 3bogC-1krhA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.37A 3bogC-1m9uA:
undetectable		 3bogC-1m9uA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.35A 3bogC-1npmA:
undetectable		 3bogC-1npmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nya CALERYTHRIN

(Saccharopolyspora
erythraea) 		PF13499
(EF-hand_7) 		3 GLY A  73
GLY A  68
GLY A  70
 None
 0.36A 3bogC-1nyaA:
undetectable		 3bogC-1nyaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 GLY A1314
GLY A1336
GLY A1334
 None
 0.33A 3bogC-1ofeA:
undetectable		 3bogC-1ofeA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		3 GLY A 278
GLY A 273
GLY A 275
 None
 0.35A 3bogC-1pe9A:
undetectable		 3bogC-1pe9A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 GLY A 280
GLY A  17
GLY A  19
 NAP  A 500 (-3.8A)
None
NAP  A 500 (-3.1A)
 0.40A 3bogC-1pz1A:
undetectable		 3bogC-1pz1A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A  40
GLY A  49
GLY A  42
 None
 0.00A 3bogC-1q5aA:
undetectable		 3bogC-1q5aA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A  49
GLY A  40
GLY A  42
 None
 0.00A 3bogC-1q5aA:
undetectable		 3bogC-1q5aA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A 348
GLY A 392
GLY A 390
 None
 0.00A 3bogC-1q5aA:
undetectable		 3bogC-1q5aA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A 392
GLY A 348
GLY A 390
 None
 0.00A 3bogC-1q5aA:
undetectable		 3bogC-1q5aA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh7 RESISTIN-LIKE BETA

(Mus musculus) 		PF06954
(Resistin) 		3 GLY A  50
GLY A  54
GLY A  52
 None
 0.40A 3bogC-1rh7A:
undetectable		 3bogC-1rh7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 GLY A 218
GLY A 161
GLY A 184
 None
 0.40A 3bogC-1ru4A:
undetectable		 3bogC-1ru4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 GLY A 297
GLY A 269
GLY A 271
 None
 0.27A 3bogC-1ru4A:
undetectable		 3bogC-1ru4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		3 GLY A  95
GLY A 185
GLY A  79
 None
 0.38A 3bogC-1sawA:
undetectable		 3bogC-1sawA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		3 GLY A 262
GLY A  10
GLY A  14
 None
 0.40A 3bogC-1t5jA:
undetectable		 3bogC-1t5jA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		3 GLY A 242
GLY A 250
GLY A 246
 None
 0.32A 3bogC-1to6A:
undetectable		 3bogC-1to6A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		3 GLY A 119
GLY A  39
GLY A  41
 None
 0.40A 3bogC-1udxA:
undetectable		 3bogC-1udxA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uju SCRIBBLE

(Homo sapiens) 		PF00595
(PDZ) 		3 GLY A  33
GLY A  45
GLY A  30
 None
 0.39A 3bogC-1ujuA:
undetectable		 3bogC-1ujuA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		3 GLY A  11
GLY A 313
GLY A 315
 None
 0.34A 3bogC-1v72A:
undetectable		 3bogC-1v72A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 GLY A  99
GLY A 136
GLY A 133
 GTP  A 500 (-3.3A)
GTP  A 500 (-3.9A)
GTP  A 500 (-2.9A)
 0.40A 3bogC-1w5eA:
undetectable		 3bogC-1w5eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		3 GLY A 257
GLY A 254
GLY A 250
 None
 0.40A 3bogC-1w5tA:
undetectable		 3bogC-1w5tA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		3 GLY A 197
GLY A 193
GLY A  43
 None
 0.41A 3bogC-1ym0A:
undetectable		 3bogC-1ym0A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		3 GLY A  22
GLY A  40
GLY A  42
 None
 0.40A 3bogC-1ynaA:
undetectable		 3bogC-1ynaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yox HYPOTHETICAL PROTEIN
PA3696

(Pseudomonas
aeruginosa) 		PF01987
(AIM24) 		3 GLY A 170
GLY A 216
GLY A 214
 None
 0.34A 3bogC-1yoxA:
undetectable		 3bogC-1yoxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr7 ATP(GTP)BINDING
PROTEIN

(Pyrococcus
abyssi) 		PF03029
(ATP_bind_1) 		3 GLY A  68
GLY A  63
GLY A  65
 None
 0.34A 3bogC-1yr7A:
undetectable		 3bogC-1yr7A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys5 LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		3 GLY A  64
GLY A 151
GLY A  59
 None
 0.37A 3bogC-1ys5A:
undetectable		 3bogC-1ys5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 GLY A 507
GLY A 482
GLY A 503
 None
 0.35A 3bogC-1zy9A:
undetectable		 3bogC-1zy9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLY B 663
GLY B 659
GLY B 508
 None
 0.38A 3bogC-2asuB:
undetectable		 3bogC-2asuB:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		3 GLY A  56
GLY A 155
GLY A  54
 NAP  A2001 (-3.2A)
NAP  A2001 (-4.2A)
NAP  A2001 (-3.1A)
 0.37A 3bogC-2aznA:
undetectable		 3bogC-2aznA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		3 GLY A 289
GLY A 353
GLY A 351
 None
SO4  A 424 ( 4.3A)
None
 0.39A 3bogC-2b9lA:
undetectable		 3bogC-2b9lA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		3 GLY A 321
GLY A 317
GLY A 319
 ATP  A1386 (-3.7A)
ATP  A1386 (-3.8A)
ATP  A1386 (-2.9A)
 0.34A 3bogC-2bu2A:
undetectable		 3bogC-2bu2A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		3 GLY A 204
GLY A 198
GLY A 196
 EDO  A  16 (-4.0A)
None
None
 0.39A 3bogC-2etvA:
undetectable		 3bogC-2etvA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		3 GLY A  28
GLY A  23
GLY A  25
 None
 0.41A 3bogC-2h34A:
undetectable		 3bogC-2h34A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA

(Mycobacterium
tuberculosis) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 GLY A 119
GLY A 114
GLY A 116
 None
 0.37A 3bogC-2h5xA:
undetectable		 3bogC-2h5xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		3 GLY A  95
GLY A 145
GLY A 143
 None
 0.36A 3bogC-2h98A:
undetectable		 3bogC-2h98A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 GLY A  78
GLY A  82
GLY A  80
 None
 0.38A 3bogC-2iukA:
undetectable		 3bogC-2iukA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		3 GLY D 152
GLY D 235
GLY D 239
 None
 0.38A 3bogC-2j5gD:
undetectable		 3bogC-2j5gD:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 GLY A 225
GLY A 251
GLY A 249
 None
 0.33A 3bogC-2jk0A:
undetectable		 3bogC-2jk0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k20 PARTITIONING-DEFECTI
VE 3 HOMOLOG

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 GLY A  53
GLY A  25
GLY A  27
 None
 0.35A 3bogC-2k20A:
undetectable		 3bogC-2k20A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		3 GLY A  50
GLY A  26
GLY A  28
 None
 0.39A 3bogC-2kpkA:
undetectable		 3bogC-2kpkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwa HEMAGGLUTININ FUSION
PEPTIDE G8A MUTANT

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLY A   4
GLY A  16
GLY A  20
 None
 0.40A 3bogC-2lwaA:
undetectable		 3bogC-2lwaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		3 GLY A 181
GLY A 216
GLY A 179
 None
 0.36A 3bogC-2ok8A:
undetectable		 3bogC-2ok8A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		3 GLY A 328
GLY A 333
GLY A 331
 None
 0.41A 3bogC-2p7nA:
undetectable		 3bogC-2p7nA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		3 GLY A 104
GLY A  59
GLY A  56
 None
 0.40A 3bogC-2pfeA:
undetectable		 3bogC-2pfeA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 3 GLY A  63
GLY A  31
GLY A  33
 None
 0.32A 3bogC-2pneA:
undetectable		 3bogC-2pneA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 3 GLY A  66
GLY A  34
GLY A  36
 None
 0.27A 3bogC-2pneA:
undetectable		 3bogC-2pneA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 3 GLY A  69
GLY A  37
GLY A  39
 None
 0.40A 3bogC-2pneA:
undetectable		 3bogC-2pneA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pr7 HALOACID
DEHALOGENASE/EPOXIDE
HYDROLASE FAMILY

(Corynebacterium
glutamicum) 		PF00702
(Hydrolase) 		3 GLY A   3
GLY A  33
GLY A  35
 None
 0.30A 3bogC-2pr7A:
undetectable		 3bogC-2pr7A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		3 GLY A 174
GLY A 148
GLY A 150
 None
 0.35A 3bogC-2pyhA:
undetectable		 3bogC-2pyhA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLY A 118
GLY A 143
GLY A 116
 None
 0.39A 3bogC-2qdxA:
undetectable		 3bogC-2qdxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9

(Homo sapiens) 		PF06821
(Ser_hydrolase) 		3 GLY A  16
GLY A  12
GLY A  14
 None
 0.33A 3bogC-2qs9A:
undetectable		 3bogC-2qs9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		3 GLY A 485
GLY A 273
GLY A 275
 None
 0.41A 3bogC-2qveA:
undetectable		 3bogC-2qveA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		3 GLY A  26
GLY A  52
GLY A  54
 None
 0.40A 3bogC-2r3bA:
undetectable		 3bogC-2r3bA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		3 GLY A 300
GLY A 142
GLY A 303
 None
 0.37A 3bogC-2r9hA:
undetectable		 3bogC-2r9hA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc5 FERREDOXIN-NADP
REDUCTASE

(Leptospira
interrogans) 		PF00175
(NAD_binding_1) 		3 GLY A 176
GLY A 204
GLY A 174
 None
 0.41A 3bogC-2rc5A:
undetectable		 3bogC-2rc5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzf NAPHTHOATE SYNTHASE

(Staphylococcus
aureus) 		PF00378
(ECH_1) 		3 GLY A 122
GLY A 141
GLY A 120
 None
None
CAA  A1274 ( 4.3A)
 0.41A 3bogC-2uzfA:
undetectable		 3bogC-2uzfA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		3 GLY A 507
GLY A 483
GLY A 485
 None
 0.41A 3bogC-2v5iA:
undetectable		 3bogC-2v5iA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 GLY A1277
GLY A1299
GLY A1297
 None
 0.40A 3bogC-2vdcA:
undetectable		 3bogC-2vdcA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjw GAF FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01590
(GAF) 		3 GLY A 315
GLY A 340
GLY A 338
 None
 0.39A 3bogC-2vjwA:
undetectable		 3bogC-2vjwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpi GMP SYNTHASE

(Homo sapiens) 		PF00117
(GATase) 		3 GLY A 102
GLY A  76
GLY A 106
 None
 0.37A 3bogC-2vpiA:
undetectable		 3bogC-2vpiA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		3 GLY A   4
GLY A 174
GLY A 176
 None
 0.39A 3bogC-2vsgA:
undetectable		 3bogC-2vsgA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 GLY A 102
GLY A  76
GLY A 106
 None
 0.38A 3bogC-2vxoA:
undetectable		 3bogC-2vxoA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY A 232
GLY A 227
GLY A 229
 None
XK9  A1511 ( 4.5A)
None
 0.31A 3bogC-2xk9A:
undetectable		 3bogC-2xk9A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		3 GLY A 243
GLY A 247
GLY A 245
 None
 0.38A 3bogC-2xu0A:
undetectable		 3bogC-2xu0A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		3 GLY A 243
GLY A 247
GLY A 245
 SO4  A1720 (-4.1A)
None
None
 0.39A 3bogC-2yk0A:
undetectable		 3bogC-2yk0A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywj GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Methanocaldococcus
jannaschii) 		PF01174
(SNO) 		3 GLY A  73
GLY A  45
GLY A  77
 None
 0.37A 3bogC-2ywjA:
undetectable		 3bogC-2ywjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		3 GLY A  17
GLY A 256
GLY A 260
 None
 0.40A 3bogC-2yzwA:
undetectable		 3bogC-2yzwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		3 GLY A 256
GLY A  17
GLY A  21
 None
 0.39A 3bogC-2yzwA:
undetectable		 3bogC-2yzwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		3 GLY A 260
GLY A  13
GLY A  17
 None
 0.40A 3bogC-2yzwA:
undetectable		 3bogC-2yzwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLY A 211
GLY A 207
GLY A  45
 None
 0.41A 3bogC-2zecA:
undetectable		 3bogC-2zecA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLY A 184
GLY A 180
GLY A  27
 None
 0.36A 3bogC-2zghA:
undetectable		 3bogC-2zghA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 GLY A 296
GLY A 367
GLY A 365
 None
 0.41A 3bogC-2zl5A:
undetectable		 3bogC-2zl5A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		3 GLY A 149
GLY A 161
GLY A 147
 None
 0.39A 3bogC-3a21A:
undetectable		 3bogC-3a21A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 GLY A 415
GLY A 418
GLY A 439
 None
 0.35A 3bogC-3ak5A:
undetectable		 3bogC-3ak5A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		3 GLY A  25
GLY A  51
GLY A  53
 None
 0.38A 3bogC-3bgkA:
undetectable		 3bogC-3bgkA:
13.29