SIMILAR PATTERNS OF AMINO ACIDS FOR 3BOG_C_DHIC8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		3 SER A 251
GLY A 247
GLY A 236
 None
 0.55A 3bogA-1am5A:
0.0
3bogC-1am5A:
0.0		 3bogA-1am5A:
undetectable
3bogC-1am5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		3 SER A 152
GLY A 148
GLY A 204
 None
 0.52A 3bogA-1ddzA:
0.0
3bogC-1ddzA:
undetectable		 3bogA-1ddzA:
undetectable
3bogC-1ddzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 3 SER A 202
GLY A 211
GLY A   8
 None
 0.54A 3bogA-1delA:
0.0
3bogC-1delA:
undetectable		 3bogA-1delA:
undetectable
3bogC-1delA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 120
GLY A  20
GLY A  16
 None
 0.47A 3bogA-1dm3A:
0.0
3bogC-1dm3A:
0.0		 3bogA-1dm3A:
undetectable
3bogC-1dm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 SER P 406
GLY P 303
GLY P 309
 None
 0.53A 3bogA-1e33P:
0.0
3bogC-1e33P:
0.0		 3bogA-1e33P:
undetectable
3bogC-1e33P:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 B
CHAIN)

(Trichosanthes
kirilowii) 		PF00652
(Ricin_B_lectin) 		3 SER B 114
GLY B 135
GLY B  20
 None
 0.56A 3bogA-1ggpB:
0.0
3bogC-1ggpB:
undetectable		 3bogA-1ggpB:
undetectable
3bogC-1ggpB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glo CATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 SER A  57
GLY A  62
GLY A  69
 None
 0.54A 3bogA-1gloA:
0.0
3bogC-1gloA:
0.0		 3bogA-1gloA:
undetectable
3bogC-1gloA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 SER A  78
GLY A  73
GLY A  59
 CA  A1345 (-2.4A)
None
None
 0.56A 3bogA-1h3jA:
0.0
3bogC-1h3jA:
0.0		 3bogA-1h3jA:
undetectable
3bogC-1h3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 SER A 856
GLY A 860
GLY A 801
 None
 0.46A 3bogA-1hwwA:
0.0
3bogC-1hwwA:
0.0		 3bogA-1hwwA:
undetectable
3bogC-1hwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 SER A 603
GLY A 243
GLY A 241
 None
 0.50A 3bogA-1l5jA:
undetectable
3bogC-1l5jA:
undetectable		 3bogA-1l5jA:
undetectable
3bogC-1l5jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  57
GLY A  27
GLY A  29
 CL  A1005 (-4.2A)
None
None
 0.48A 3bogA-1lk5A:
undetectable
3bogC-1lk5A:
undetectable		 3bogA-1lk5A:
undetectable
3bogC-1lk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 SER A  70
GLY A  66
GLY A  64
 CA  A 351 (-2.4A)
CA  A 351 (-4.3A)
None
 0.55A 3bogA-1llpA:
undetectable
3bogC-1llpA:
undetectable		 3bogA-1llpA:
undetectable
3bogC-1llpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 SER A 765
GLY A 795
GLY A 797
 None
None
MTE  A3003 (-3.3A)
 0.55A 3bogA-1n5xA:
undetectable
3bogC-1n5xA:
undetectable		 3bogA-1n5xA:
undetectable
3bogC-1n5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  53
GLY A  27
GLY A  29
 None
None
ABF  A1269 ( 3.7A)
 0.54A 3bogA-1o8bA:
undetectable
3bogC-1o8bA:
undetectable		 3bogA-1o8bA:
undetectable
3bogC-1o8bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		3 SER A 470
GLY A 473
GLY A 477
 None
 0.39A 3bogA-1qonA:
undetectable
3bogC-1qonA:
undetectable		 3bogA-1qonA:
undetectable
3bogC-1qonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 SER A  70
GLY A  66
GLY A  64
 CA  A 352 (-2.5A)
CA  A 352 (-4.4A)
None
 0.49A 3bogA-1qpaA:
undetectable
3bogC-1qpaA:
undetectable		 3bogA-1qpaA:
undetectable
3bogC-1qpaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 SER A  34
GLY A 115
GLY A 146
 None
 0.46A 3bogA-1ru4A:
undetectable
3bogC-1ru4A:
undetectable		 3bogA-1ru4A:
undetectable
3bogC-1ru4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		3 SER A 220
GLY A 156
GLY A 130
 PMS  A1284 (-2.1A)
PMS  A1284 (-3.5A)
PMS  A1284 (-3.3A)
 0.57A 3bogA-1s2nA:
undetectable
3bogC-1s2nA:
undetectable		 3bogA-1s2nA:
undetectable
3bogC-1s2nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		3 SER A 147
GLY A 154
GLY A 115
 None
 0.52A 3bogA-1sr8A:
undetectable
3bogC-1sr8A:
undetectable		 3bogA-1sr8A:
undetectable
3bogC-1sr8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		3 SER A  41
GLY A  44
GLY A   9
 None
None
SO4  A 192 (-3.2A)
 0.57A 3bogA-1t35A:
undetectable
3bogC-1t35A:
undetectable		 3bogA-1t35A:
undetectable
3bogC-1t35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 SER A  45
GLY A 154
GLY A 156
 None
 0.56A 3bogA-1tvzA:
undetectable
3bogC-1tvzA:
undetectable		 3bogA-1tvzA:
undetectable
3bogC-1tvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  59
GLY A  29
GLY A  31
 None
 0.49A 3bogA-1uj4A:
undetectable
3bogC-1uj4A:
undetectable		 3bogA-1uj4A:
undetectable
3bogC-1uj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 120
GLY A  19
GLY A  15
 None
 0.54A 3bogA-1ulqA:
undetectable
3bogC-1ulqA:
undetectable		 3bogA-1ulqA:
undetectable
3bogC-1ulqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 SER A 148
GLY A 219
GLY A 240
 None
None
NAP  A1350 (-3.4A)
 0.48A 3bogA-1v3tA:
undetectable
3bogC-1v3tA:
undetectable		 3bogA-1v3tA:
undetectable
3bogC-1v3tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		3 SER A 369
GLY A 158
GLY A 131
 PMS  A 501 (-1.5A)
PMS  A 501 ( 4.6A)
PMS  A 501 (-4.3A)
 0.49A 3bogA-1v6cA:
undetectable
3bogC-1v6cA:
undetectable		 3bogA-1v6cA:
undetectable
3bogC-1v6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl1 6-PHOSPHOGLUCONOLACT
ONASE

(Thermotoga
maritima) 		PF01182
(Glucosamine_iso) 		3 SER A  67
GLY A  41
GLY A 132
 None
 0.54A 3bogA-1vl1A:
undetectable
3bogC-1vl1A:
undetectable		 3bogA-1vl1A:
undetectable
3bogC-1vl1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 123
GLY A  23
GLY A  19
 None
 0.43A 3bogA-1wl4A:
undetectable
3bogC-1wl4A:
undetectable		 3bogA-1wl4A:
undetectable
3bogC-1wl4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A 158
GLY A 181
GLY A 320
 NAP  A 801 (-2.7A)
NAP  A 801 (-3.5A)
NAP  A 801 ( 3.3A)
 0.55A 3bogA-1yb5A:
undetectable
3bogC-1yb5A:
undetectable		 3bogA-1yb5A:
undetectable
3bogC-1yb5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		3 SER A 192
GLY A 163
GLY A 168
 None
PO4  A 277 (-4.1A)
None
 0.45A 3bogA-1ywfA:
undetectable
3bogC-1ywfA:
undetectable		 3bogA-1ywfA:
undetectable
3bogC-1ywfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A

(Homo sapiens) 		PF00782
(DSPc) 		3 SER A 143
GLY A 108
GLY A 110
 None
 0.57A 3bogA-1yz4A:
undetectable
3bogC-1yz4A:
undetectable		 3bogA-1yz4A:
undetectable
3bogC-1yz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		3 SER A  35
GLY A 170
GLY A 184
 None
None
PCA  A   1 ( 3.3A)
 0.45A 3bogA-2a39A:
undetectable
3bogC-2a39A:
undetectable		 3bogA-2a39A:
undetectable
3bogC-2a39A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		3 SER A 252
GLY A 264
GLY A 294
 None
 0.51A 3bogA-2a8iA:
undetectable
3bogC-2a8iA:
undetectable		 3bogA-2a8iA:
undetectable
3bogC-2a8iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 SER A 122
GLY A 146
GLY A 115
 None
 0.56A 3bogA-2ag8A:
undetectable
3bogC-2ag8A:
undetectable		 3bogA-2ag8A:
undetectable
3bogC-2ag8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 SER A 410
GLY A 249
GLY A 296
 None
 0.49A 3bogA-2bmoA:
undetectable
3bogC-2bmoA:
undetectable		 3bogA-2bmoA:
undetectable
3bogC-2bmoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 SER A 156
GLY A 161
GLY A 168
 None
 0.55A 3bogA-2c0yA:
undetectable
3bogC-2c0yA:
undetectable		 3bogA-2c0yA:
undetectable
3bogC-2c0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 SER A 184
GLY A 181
GLY A 178
 None
None
FAD  A 699 (-4.2A)
 0.46A 3bogA-2ddhA:
undetectable
3bogC-2ddhA:
undetectable		 3bogA-2ddhA:
undetectable
3bogC-2ddhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		3 SER A 139
GLY A 134
GLY A 161
 ASP  A 901 (-2.7A)
None
ASP  A 901 (-3.2A)
 0.52A 3bogA-2f5xA:
undetectable
3bogC-2f5xA:
undetectable		 3bogA-2f5xA:
undetectable
3bogC-2f5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8m RIBOSE 5-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  56
GLY A  26
GLY A  28
 None
None
PO4  A 700 ( 3.9A)
 0.52A 3bogA-2f8mA:
undetectable
3bogC-2f8mA:
undetectable		 3bogA-2f8mA:
undetectable
3bogC-2f8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 SER A 249
GLY A 251
GLY A 253
 None
 0.51A 3bogA-2fafA:
undetectable
3bogC-2fafA:
undetectable		 3bogA-2fafA:
undetectable
3bogC-2fafA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257

(Bacteroides
thetaiotaomicron) 		PF01661
(Macro) 		3 SER A 117
GLY A  17
GLY A  15
 None
 0.45A 3bogA-2fg1A:
undetectable
3bogC-2fg1A:
undetectable		 3bogA-2fg1A:
undetectable
3bogC-2fg1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		3 SER A 100
GLY A 109
GLY A 136
 None
 0.55A 3bogA-2gwgA:
undetectable
3bogC-2gwgA:
undetectable		 3bogA-2gwgA:
undetectable
3bogC-2gwgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		3 SER A 175
GLY A 150
GLY A 148
 None
 0.57A 3bogA-2hg4A:
undetectable
3bogC-2hg4A:
undetectable		 3bogA-2hg4A:
undetectable
3bogC-2hg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvz SPLICING FACTOR,
ARGININE/SERINE-RICH
7

(Homo sapiens) 		PF00076
(RRM_1) 		3 SER A  65
GLY A  11
GLY A  13
 None
 0.56A 3bogA-2hvzA:
undetectable
3bogC-2hvzA:
undetectable		 3bogA-2hvzA:
undetectable
3bogC-2hvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 157
GLY A  57
GLY A  53
 None
 0.49A 3bogA-2ibuA:
undetectable
3bogC-2ibuA:
undetectable		 3bogA-2ibuA:
undetectable
3bogC-2ibuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 SER A 100
GLY A 124
GLY A 126
 None
None
ADP  A1001 (-3.3A)
 0.53A 3bogA-2iopA:
undetectable
3bogC-2iopA:
undetectable		 3bogA-2iopA:
undetectable
3bogC-2iopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 SER A 162
GLY A 234
GLY A 255
 None
 0.56A 3bogA-2j3hA:
undetectable
3bogC-2j3hA:
undetectable		 3bogA-2j3hA:
undetectable
3bogC-2j3hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o55 PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Galdieria
sulphuraria) 		PF03009
(GDPD) 		3 SER A  30
GLY A  18
GLY A  13
 None
 0.48A 3bogA-2o55A:
undetectable
3bogC-2o55A:
undetectable		 3bogA-2o55A:
undetectable
3bogC-2o55A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 SER A 682
GLY A 712
GLY A 708
 None
 0.53A 3bogA-2oajA:
undetectable
3bogC-2oajA:
undetectable		 3bogA-2oajA:
undetectable
3bogC-2oajA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 SER A 824
GLY A 916
GLY A 919
 None
 0.56A 3bogA-2po4A:
undetectable
3bogC-2po4A:
undetectable		 3bogA-2po4A:
undetectable
3bogC-2po4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 SER A1007
GLY A 712
GLY A 720
 None
 0.57A 3bogA-2q1fA:
undetectable
3bogC-2q1fA:
undetectable		 3bogA-2q1fA:
undetectable
3bogC-2q1fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 SER A 435
GLY A  17
GLY A 368
 None
 0.53A 3bogA-2v7gA:
undetectable
3bogC-2v7gA:
undetectable		 3bogA-2v7gA:
undetectable
3bogC-2v7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 SER A 616
GLY A 620
GLY A 947
 None
 0.37A 3bogA-2vsqA:
undetectable
3bogC-2vsqA:
undetectable		 3bogA-2vsqA:
undetectable
3bogC-2vsqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 SER B 195
GLY B 225
GLY B 227
 None
None
XAX  B1778 (-3.3A)
 0.53A 3bogA-2w55B:
undetectable
3bogC-2w55B:
undetectable		 3bogA-2w55B:
undetectable
3bogC-2w55B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 SER A 753
GLY A 397
GLY A 402
 None
 0.53A 3bogA-2y8nA:
undetectable
3bogC-2y8nA:
undetectable		 3bogA-2y8nA:
undetectable
3bogC-2y8nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		3 SER A 207
GLY A 189
GLY A 187
 None
 0.54A 3bogA-2z23A:
undetectable
3bogC-2z23A:
undetectable		 3bogA-2z23A:
undetectable
3bogC-2z23A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 SER A 161
GLY A 233
GLY A 254
 None
None
NDP  A 900 (-3.4A)
 0.44A 3bogA-2zb3A:
undetectable
3bogC-2zb3A:
undetectable		 3bogA-2zb3A:
undetectable
3bogC-2zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 SER A 161
GLY A 233
GLY A 254
 None
None
NAP  A 500 (-3.1A)
 0.49A 3bogA-2zb4A:
undetectable
3bogC-2zb4A:
undetectable		 3bogA-2zb4A:
undetectable
3bogC-2zb4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 SER A 216
GLY A 218
GLY A 220
 None
 0.49A 3bogA-2zciA:
undetectable
3bogC-2zciA:
undetectable		 3bogA-2zciA:
undetectable
3bogC-2zciA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 SER A 515
GLY A 446
GLY A 444
 None
 0.40A 3bogA-3afgA:
undetectable
3bogC-3afgA:
undetectable		 3bogA-3afgA:
undetectable
3bogC-3afgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 SER A 238
GLY A 254
GLY A 282
 None
 0.41A 3bogA-3ak5A:
undetectable
3bogC-3ak5A:
undetectable		 3bogA-3ak5A:
undetectable
3bogC-3ak5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 SER A 301
GLY A 307
GLY A 345
 None
 0.56A 3bogA-3eqnA:
undetectable
3bogC-3eqnA:
undetectable		 3bogA-3eqnA:
undetectable
3bogC-3eqnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		3 SER A 137
GLY A  84
GLY A  88
 UNL  A 358 ( 4.9A)
None
None
 0.57A 3bogA-3f0hA:
undetectable
3bogC-3f0hA:
undetectable		 3bogA-3f0hA:
undetectable
3bogC-3f0hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		3 SER A 130
GLY A 174
GLY A 242
 None
 0.57A 3bogA-3fcjA:
undetectable
3bogC-3fcjA:
undetectable		 3bogA-3fcjA:
undetectable
3bogC-3fcjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  76
GLY A  48
GLY A  50
 None
None
5RP  A 501 ( 3.9A)
 0.51A 3bogA-3hheA:
undetectable
3bogC-3hheA:
undetectable		 3bogA-3hheA:
undetectable
3bogC-3hheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		3 SER 4 359
GLY 4 362
GLY 5 191
 None
 0.55A 3bogA-3i9v4:
undetectable
3bogC-3i9v4:
undetectable		 3bogA-3i9v4:
undetectable
3bogC-3i9v4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Methanocaldococcus
jannaschii) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  56
GLY A  27
GLY A  29
 None
None
PGO  A 232 (-3.4A)
 0.48A 3bogA-3ixqA:
undetectable
3bogC-3ixqA:
undetectable		 3bogA-3ixqA:
undetectable
3bogC-3ixqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 3 SER D 141
GLY D 138
GLY D  88
 None
 0.45A 3bogA-3jazD:
undetectable
3bogC-3jazD:
undetectable		 3bogA-3jazD:
undetectable
3bogC-3jazD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		3 SER A 425
GLY A 262
GLY A 260
 None
 0.55A 3bogA-3k5wA:
undetectable
3bogC-3k5wA:
undetectable		 3bogA-3k5wA:
undetectable
3bogC-3k5wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6e OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Aeromonas
hydrophila) 		PF00106
(adh_short) 		3 SER A 107
GLY A  86
GLY A  88
 None
 0.55A 3bogA-3l6eA:
undetectable
3bogC-3l6eA:
undetectable		 3bogA-3l6eA:
undetectable
3bogC-3l6eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		3 SER A  78
GLY A  73
GLY A  62
 None
 0.55A 3bogA-3mkhA:
undetectable
3bogC-3mkhA:
undetectable		 3bogA-3mkhA:
undetectable
3bogC-3mkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 SER A 310
GLY A 201
GLY A 170
 None
 0.54A 3bogA-3njbA:
undetectable
3bogC-3njbA:
undetectable		 3bogA-3njbA:
undetectable
3bogC-3njbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovz CATHEPSIN K

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 SER A  24
GLY A  20
GLY A  91
 None
 0.55A 3bogA-3ovzA:
undetectable
3bogC-3ovzA:
undetectable		 3bogA-3ovzA:
undetectable
3bogC-3ovzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 SER A 150
GLY A 145
GLY A 130
 None
FAD  A 501 ( 3.7A)
FAD  A 501 (-3.2A)
 0.56A 3bogA-3rj8A:
undetectable
3bogC-3rj8A:
undetectable		 3bogA-3rj8A:
undetectable
3bogC-3rj8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		3 SER A  28
GLY A  99
GLY A  31
 None
 0.50A 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable		 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		3 SER A  28
GLY A  99
GLY A  39
 None
 0.53A 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable		 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A  39
GLY A 125
GLY A 122
 None
 0.40A 3bogA-3s2gA:
undetectable
3bogC-3s2gA:
undetectable		 3bogA-3s2gA:
undetectable
3bogC-3s2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		3 SER A 235
GLY A 209
GLY A 172
 None
 0.40A 3bogA-3skvA:
undetectable
3bogC-3skvA:
undetectable		 3bogA-3skvA:
undetectable
3bogC-3skvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		3 SER A 645
GLY A 651
GLY A 654
 None
 0.45A 3bogA-3slkA:
undetectable
3bogC-3slkA:
undetectable		 3bogA-3slkA:
undetectable
3bogC-3slkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 SER C 765
GLY C 795
GLY C 797
 None
None
MTE  C1316 (-3.5A)
 0.57A 3bogA-3sr6C:
undetectable
3bogC-3sr6C:
undetectable		 3bogA-3sr6C:
undetectable
3bogC-3sr6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 119
GLY A  19
GLY A  15
 None
 0.39A 3bogA-3ss6A:
undetectable
3bogC-3ss6A:
undetectable		 3bogA-3ss6A:
undetectable
3bogC-3ss6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  61
GLY A  35
GLY A  37
 None
None
SO4  A 236 ( 3.7A)
 0.49A 3bogA-3u7jA:
undetectable
3bogC-3u7jA:
undetectable		 3bogA-3u7jA:
undetectable
3bogC-3u7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 SER A 266
GLY A 415
GLY A 464
 None
 0.51A 3bogA-3v4cA:
undetectable
3bogC-3v4cA:
undetectable		 3bogA-3v4cA:
undetectable
3bogC-3v4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		3 SER A   8
GLY A  83
GLY A  19
 None
 0.53A 3bogA-3zs7A:
undetectable
3bogC-3zs7A:
undetectable		 3bogA-3zs7A:
undetectable
3bogC-3zs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuy TRANSPORTER

(Neisseria
meningitidis) 		PF01758
(SBF) 		3 SER A 297
GLY A 234
GLY A 262
 None
PTY  A1319 (-3.5A)
NA  A1311 ( 4.7A)
 0.56A 3bogA-3zuyA:
undetectable
3bogC-3zuyA:
undetectable		 3bogA-3zuyA:
undetectable
3bogC-3zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx SPCU
EXOU

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		no annotation
PF01734
(Patatin) 		3 SER A  15
GLY B  69
GLY B  71
 None
 0.56A 3bogA-4akxA:
undetectable
3bogC-4akxA:
undetectable		 3bogA-4akxA:
undetectable
3bogC-4akxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 SER A 154
GLY A 225
GLY A 246
 None
None
NAP  A 400 (-3.4A)
 0.43A 3bogA-4b7xA:
undetectable
3bogC-4b7xA:
undetectable		 3bogA-4b7xA:
undetectable
3bogC-4b7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 SER A  71
GLY A  67
GLY A  65
 CA  A 401 (-2.4A)
CA  A 401 (-4.3A)
None
 0.56A 3bogA-4bm1A:
undetectable
3bogC-4bm1A:
undetectable		 3bogA-4bm1A:
undetectable
3bogC-4bm1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 123
GLY A  22
GLY A  18
 None
 0.45A 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable		 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 359
GLY A 355
GLY A  57
 None
 0.56A 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable		 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 124
GLY A  24
GLY A  20
 None
 0.39A 3bogA-4dd5A:
undetectable
3bogC-4dd5A:
undetectable		 3bogA-4dd5A:
undetectable
3bogC-4dd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 SER A 119
GLY A  19
GLY A  15
 None
 0.45A 3bogA-4e1lA:
undetectable
3bogC-4e1lA:
undetectable		 3bogA-4e1lA:
undetectable
3bogC-4e1lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		3 SER A 513
GLY A 495
GLY A 492
 None
 0.42A 3bogA-4fwwA:
undetectable
3bogC-4fwwA:
undetectable		 3bogA-4fwwA:
undetectable
3bogC-4fwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  56
GLY A  27
GLY A  29
 None
None
PO4  A 302 ( 3.8A)
 0.49A 3bogA-4gmkA:
undetectable
3bogC-4gmkA:
undetectable		 3bogA-4gmkA:
undetectable
3bogC-4gmkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		3 SER A 440
GLY A 443
GLY A 427
 None
 0.57A 3bogA-4h7nA:
undetectable
3bogC-4h7nA:
undetectable		 3bogA-4h7nA:
undetectable
3bogC-4h7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfn ALLYL ALCOHOL
DEHYDROGENASE

(Nicotiana
tabacum) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 SER A 160
GLY A 232
GLY A 253
 None
None
NAP  A 400 (-3.1A)
 0.54A 3bogA-4hfnA:
undetectable
3bogC-4hfnA:
undetectable		 3bogA-4hfnA:
undetectable
3bogC-4hfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  59
GLY A  33
GLY A  35
 None
None
PO4  A 306 ( 3.8A)
 0.51A 3bogA-4io1A:
undetectable
3bogC-4io1A:
undetectable		 3bogA-4io1A:
undetectable
3bogC-4io1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		3 SER A 233
GLY A 236
GLY A 239
 None
 0.41A 3bogA-4itmA:
undetectable
3bogC-4itmA:
undetectable		 3bogA-4itmA:
undetectable
3bogC-4itmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 3 SER B  80
GLY B 414
GLY B 270
 None
 0.38A 3bogA-4iu9B:
undetectable
3bogC-4iu9B:
undetectable		 3bogA-4iu9B:
undetectable
3bogC-4iu9B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		3 SER A  82
GLY A 417
GLY A 272
 None
GYP  A 502 (-3.4A)
None
 0.45A 3bogA-4jreA:
undetectable
3bogC-4jreA:
undetectable		 3bogA-4jreA:
undetectable
3bogC-4jreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 SER E 541
GLY E 390
GLY E 392
 HR4  E1002 (-3.2A)
HR4  E1002 ( 4.9A)
HR4  E1002 (-3.4A)
 0.56A 3bogA-4mh0E:
undetectable
3bogC-4mh0E:
undetectable		 3bogA-4mh0E:
undetectable
3bogC-4mh0E:
undetectable