SIMILAR PATTERNS OF AMINO ACIDS FOR 3BMC_B_FOLB270

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1mxf	PTERIDINE REDUCTASE 2 (Trypanosoma cruzi)	PF13561 (adh_short_C2)	6	ARG A  22 SER A 103 PRO A 107 PHE A 179 PRO A 218 MET A 221	NDP  A1277 ( 3.9A) MTX  A1278 ( 2.7A) None None MTX  A1278 ( 4.1A) MTX  A1278 (-4.6A)	0.77A	3bmcB-1mxfA: 14.4	3bmcB-1mxfA: 56.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1mxf	PTERIDINE REDUCTASE 2 (Trypanosoma cruzi)	PF13561 (adh_short_C2)	6	ARG A  22 SER A 103 PRO A 107 PHE A 179 TYR A 182 PRO A 218	NDP  A1277 ( 3.9A) MTX  A1278 ( 2.7A) None None MTX  A1278 ( 4.7A) MTX  A1278 ( 4.1A)	0.58A	3bmcB-1mxfA: 14.4	3bmcB-1mxfA: 56.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1p33	PTERIDINE REDUCTASE 1 (Leishmania tarentolae)	PF13561 (adh_short_C2)	7	ARG A  17 SER A 111 PHE A 113 PRO A 115 TYR A 194 PRO A 230 MET A 233	NDP  A 300 ( 3.7A) MTX  A 351 ( 2.8A) MTX  A 351 (-3.5A) MTX  A 351 (-4.2A) MTX  A 351 ( 4.4A) MTX  A 351 (-3.3A) MTX  A 351 ( 4.8A)	0.68A	3bmcB-1p33A: 41.5	3bmcB-1p33A: 48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2qhx	PTERIDINE REDUCTASE 1 (Leishmania major)	PF00106 (adh_short) PF13561 (adh_short_C2)	5	ARG A  17 SER A 111 PHE A 113 PRO A 115 TYR A 194	NAP  A1300 ( 3.7A) FE1  A1301 ( 2.8A) FE1  A1301 (-3.4A) None FE1  A1301 ( 4.5A)	0.33A	3bmcB-2qhxA: 40.5	3bmcB-2qhxA: 49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zkm	1-PHOSPHATIDYLINOSIT OL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2 (Homo sapiens)	PF00168 (C2) PF00387 (PI-PLC-Y) PF00388 (PI-PLC-X) PF09279 (EF-hand_like)	5	SER X 560 CYH X 621 PHE X 588 TYR X 591 GLU X 574	None	1.49A	3bmcB-2zkmX: 0.2	3bmcB-2zkmX: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oj5	TAILSPIKE PROTEIN (Escherichia virus CBA120)	no annotation	5	SER A 500 PHE A 493 TYR A 520 PRO A 480 GLU A 483	None	1.10A	3bmcB-4oj5A: 0.1	3bmcB-4oj5A: 16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pfw	ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN (Thermotoga maritima)	PF00496 (SBP_bac_5)	5	PHE A 324 PRO A 442 TYR A 445 PRO A 335 GLU A 493	None	1.39A	3bmcB-4pfwA: 0.0	3bmcB-4pfwA: 19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4wcd	PTERIDINE REDUCTASE (Trypanosoma brucei)	PF13561 (adh_short_C2)	10	ARG A  14 SER A  95 PHE A  97 PRO A  99 CYH A 168 PHE A 171 TYR A 174 PRO A 210 MET A 213 TRP A 221	NAP  A 301 (-3.7A) NAP  A 301 ( 3.1A) 3KH  A 302 (-3.5A) None 3KH  A 302 ( 4.1A) None 3KH  A 302 ( 4.7A) 3KH  A 302 ( 4.0A) None 3KH  A 302 (-3.8A)	0.29A	3bmcB-4wcdA: 45.5	3bmcB-4wcdA: 93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5tgd	FOLM ALTERNATIVE DIHYDROFOLATE REDUCTASE (Brucella suis)	PF00106 (adh_short)	5	ARG A  31 SER A 105 PHE A 107 PHE A 165 TYR A 168	NAP  A 301 (-3.9A) NAP  A 301 (-3.0A) None None None	0.53A	3bmcB-5tgdA: 32.3	3bmcB-5tgdA: 31.65