SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_G_SVRG506_3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1asx THERMOSOME

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		3 PRO A  47
PHE A  53
LYS A  49
 None
 1.22A 3bjwG-1asxA:
undetectable		 3bjwG-1asxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgv APO CIB

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 PRO A  31
PHE A  83
LYS A   1
 None
 1.24A 3bjwG-1dgvA:
0.0		 3bjwG-1dgvA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 PRO B 413
PHE B 529
LYS B 408
 None
 1.26A 3bjwG-1e9yB:
1.2		 3bjwG-1e9yB:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyp CHALCONE-FLAVONONE
ISOMERASE 1

(Medicago sativa) 		PF02431
(Chalcone) 		3 PRO A 146
PHE A  47
LYS A  97
 None
 0.99A 3bjwG-1eypA:
0.0		 3bjwG-1eypA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PRO A 223
PHE A 290
LYS A 226
 None
 1.19A 3bjwG-1fcpA:
0.0		 3bjwG-1fcpA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgv H52 FV (LIGHT CHAIN)

(Homo sapiens) 		PF07686
(V-set) 		3 PRO L   8
PHE L  83
LYS L 103
 PRO  L   8 ( 1.0A)
PHE  L  83 ( 1.3A)
LYS  L 103 ( 0.0A)
 1.25A 3bjwG-1fgvL:
0.0		 3bjwG-1fgvL:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		3 PRO A 316
PHE A 351
LYS A 496
 None
 1.20A 3bjwG-1gzvA:
0.5		 3bjwG-1gzvA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		3 PRO A 144
PHE A 250
LYS A 146
 None
 1.10A 3bjwG-1j6oA:
0.0		 3bjwG-1j6oA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 PRO A 641
PHE A 650
LYS A 639
 HEC  A 802 (-3.9A)
HEC  A 802 (-3.6A)
None
 1.24A 3bjwG-1kb0A:
0.0		 3bjwG-1kb0A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 PRO A 557
PHE A 548
LYS A 550
 None
 1.19A 3bjwG-1l0wA:
undetectable		 3bjwG-1l0wA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 PRO A  73
PHE A  65
LYS A  69
 None
 0.99A 3bjwG-1ldnA:
undetectable		 3bjwG-1ldnA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 PRO X 349
PHE X 343
LYS X 346
 None
 1.27A 3bjwG-1mw9X:
undetectable		 3bjwG-1mw9X:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf9 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZD

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		3 PRO A  79
PHE A 129
LYS A 122
 None
 0.93A 3bjwG-1nf9A:
undetectable		 3bjwG-1nf9A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq6 PROTEIN
(L-2-HALOACID
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00702
(Hydrolase) 		3 PRO A  94
PHE A   7
LYS A   9
 None
None
ASB  A   8 ( 3.3A)
 1.22A 3bjwG-1qq6A:
undetectable		 3bjwG-1qq6A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG

(Thermotoga
maritima) 		PF01628
(HrcA) 		3 PRO A  79
PHE A  86
LYS A  82
 None
 1.23A 3bjwG-1stzA:
undetectable		 3bjwG-1stzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvc METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 PRO A 219
PHE A 242
LYS A 244
 None
 0.97A 3bjwG-1tvcA:
undetectable		 3bjwG-1tvcA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		3 PRO A 475
PHE A 317
LYS A 343
 None
 1.24A 3bjwG-1vg0A:
undetectable		 3bjwG-1vg0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 PRO A 190
PHE A 229
LYS A 231
 None
 1.26A 3bjwG-1xfuA:
undetectable		 3bjwG-1xfuA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase) 		3 PRO A 156
PHE A 152
LYS A 158
 None
 1.28A 3bjwG-1ye9A:
undetectable		 3bjwG-1ye9A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 PRO A 188
PHE A   7
LYS A 190
 None
 1.18A 3bjwG-2b81A:
undetectable		 3bjwG-2b81A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		3 PRO A 296
PHE A 266
LYS A 264
 None
 1.17A 3bjwG-2bznA:
undetectable		 3bjwG-2bznA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		3 PRO A 264
PHE A 215
LYS A 259
 None
 0.70A 3bjwG-2ddtA:
undetectable		 3bjwG-2ddtA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgu HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN Q

(Homo sapiens) 		PF00076
(RRM_1) 		3 PRO A 409
PHE A 405
LYS A 407
 None
 1.04A 3bjwG-2dguA:
undetectable		 3bjwG-2dguA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex3 DNA TERMINAL PROTEIN

(Bacillus virus
phi29) 		PF05435
(Phi-29_GP3) 		3 PRO B 145
PHE B 148
LYS B  99
 None
 1.21A 3bjwG-2ex3B:
undetectable		 3bjwG-2ex3B:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i04 MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		3 PRO A 486
PHE A 519
LYS A 457
 None
 1.27A 3bjwG-2i04A:
undetectable		 3bjwG-2i04A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		3 PRO A 231
PHE A 448
LYS A 238
 None
 1.13A 3bjwG-2j0wA:
0.0		 3bjwG-2j0wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lju PUTATIVE
OXIDOREDUCTASE

(Ehrlichia
chaffeensis) 		PF04800
(ETC_C1_NDUFA4) 		3 PRO A  15
PHE A  62
LYS A  28
 None
 1.26A 3bjwG-2ljuA:
undetectable		 3bjwG-2ljuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		3 PRO A  83
PHE A 355
LYS A  81
 None
 1.16A 3bjwG-2oewA:
1.1		 3bjwG-2oewA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2orz NEUROPILIN-1

(Rattus
norvegicus) 		PF00754
(F5_F8_type_C) 		3 PRO A 566
PHE A 540
LYS A 514
 None
 1.13A 3bjwG-2orzA:
undetectable		 3bjwG-2orzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		3 PRO A 257
PHE A 237
LYS A 259
 None
 1.28A 3bjwG-2pbyA:
undetectable		 3bjwG-2pbyA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 PRO A 883
PHE A 875
LYS A 880
 None
 1.28A 3bjwG-2qf7A:
undetectable		 3bjwG-2qf7A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		3 PRO A 546
PHE A 563
LYS A 547
 None
 1.23A 3bjwG-2qqkA:
undetectable		 3bjwG-2qqkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		3 PRO A 546
PHE A 563
LYS A 547
 None
 1.20A 3bjwG-2qqoA:
undetectable		 3bjwG-2qqoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rv1 ZINC FINGER PROTEIN
ZFAT

(Homo sapiens) 		no annotation 3 PRO A  13
PHE A  17
LYS A  11
 None
 1.28A 3bjwG-2rv1A:
undetectable		 3bjwG-2rv1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		3 PRO A 522
PHE A 439
LYS A 441
 None
 1.26A 3bjwG-2wzgA:
undetectable		 3bjwG-2wzgA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yax SULFUR
OXYGENASE/REDUCTASE

(Acidianus
ambivalens) 		PF07682
(SOR) 		3 PRO B   4
PHE B  40
LYS B  81
 None
 1.21A 3bjwG-2yaxB:
undetectable		 3bjwG-2yaxB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PRO A 222
PHE A 264
LYS A 224
 None
None
SRM  A 601 (-2.6A)
 1.07A 3bjwG-3b0hA:
undetectable		 3bjwG-3b0hA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxv SULFUR
OXYGENASE/REDUCTASE

(Acidianus
tengchongensis) 		PF07682
(SOR) 		3 PRO A   4
PHE A  40
LYS A  81
 None
 1.15A 3bjwG-3bxvA:
undetectable		 3bjwG-3bxvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		3 PRO A 297
PHE A 410
LYS A 392
 None
 1.28A 3bjwG-3eafA:
undetectable		 3bjwG-3eafA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		3 PRO A  81
PHE A  19
LYS A  31
 None
 1.19A 3bjwG-3fcxA:
undetectable		 3bjwG-3fcxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		3 PRO D 331
PHE D 210
LYS D 215
 None
 1.14A 3bjwG-3fo8D:
undetectable		 3bjwG-3fo8D:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		3 PRO A 331
PHE A 210
LYS A 215
 None
 1.23A 3bjwG-3foaA:
undetectable		 3bjwG-3foaA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe) 		PF08652
(RAI1) 		3 PRO B 177
PHE B  58
LYS B 148
 None
 1.01A 3bjwG-3fqdB:
undetectable		 3bjwG-3fqdB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4p PROTEASOME SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 PRO a 141
PHE a 177
LYS a   7
 None
 0.99A 3bjwG-3h4pa:
1.1		 3bjwG-3h4pa:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		3 PRO A 315
PHE A 350
LYS A 493
 None
 1.26A 3bjwG-3hjbA:
undetectable		 3bjwG-3hjbA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icy SENSOR PROTEIN

(Chlorobaculum
tepidum) 		PF08447
(PAS_3) 		3 PRO A  83
PHE A  32
LYS A  86
 None
 1.14A 3bjwG-3icyA:
undetectable		 3bjwG-3icyA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 PRO U 331
PHE U 210
LYS U 215
 None
 1.23A 3bjwG-3j2nU:
undetectable		 3bjwG-3j2nU:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l82 F-BOX ONLY PROTEIN 4

(Homo sapiens) 		no annotation 3 PRO B 177
PHE B 223
LYS B 230
 None
 1.20A 3bjwG-3l82B:
undetectable		 3bjwG-3l82B:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		3 PRO A 314
PHE A 349
LYS A 492
 None
 1.19A 3bjwG-3nbuA:
undetectable		 3bjwG-3nbuA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 PRO B 188
PHE B 196
LYS B 191
 None
 1.24A 3bjwG-3p8cB:
undetectable		 3bjwG-3p8cB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5t TCR N30 BETA

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO A 130
PHE A 196
LYS A 140
 None
 1.07A 3bjwG-3q5tA:
undetectable		 3bjwG-3q5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		3 PRO A 283
PHE A 242
LYS A 249
 None
 1.25A 3bjwG-3r2gA:
undetectable		 3bjwG-3r2gA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r77 PROBABLE
ISOCHORISMATASE

(Pseudomonas
fluorescens) 		PF00857
(Isochorismatase) 		3 PRO A  79
PHE A 129
LYS A 122
 None
None
QLI  A 500 (-2.6A)
 1.02A 3bjwG-3r77A:
undetectable		 3bjwG-3r77A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		3 PRO A 218
PHE A 193
LYS A 219
 None
 1.28A 3bjwG-3t05A:
undetectable		 3bjwG-3t05A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PRO A 672
PHE A 613
LYS A 674
 None
 1.17A 3bjwG-3u4aA:
undetectable		 3bjwG-3u4aA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uz0 STAGE II SPORULATION
PROTEIN Q

(Bacillus
subtilis) 		PF01551
(Peptidase_M23) 		3 PRO B  82
PHE B 219
LYS B  78
 None
 1.23A 3bjwG-3uz0B:
undetectable		 3bjwG-3uz0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PRO A 222
PHE A 264
LYS A 224
 None
None
SO3  A 606 ( 2.2A)
 1.01A 3bjwG-3vlyA:
undetectable		 3bjwG-3vlyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc4 SSO1398

(Sulfolobus
solfataricus) 		no annotation 3 PRO A 132
PHE A  24
LYS A  20
 None
 0.93A 3bjwG-3zc4A:
undetectable		 3bjwG-3zc4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhp CALCIUM-BINDING
PROTEIN 39-LIKE

(Homo sapiens) 		PF08569
(Mo25) 		3 PRO A 289
PHE A 280
LYS A 286
 None
 1.05A 3bjwG-3zhpA:
undetectable		 3bjwG-3zhpA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		3 PRO A 579
PHE A 572
LYS A 576
 None
 1.12A 3bjwG-4a2wA:
1.9		 3bjwG-4a2wA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		3 PRO A 322
PHE A 228
LYS A 233
 None
 1.26A 3bjwG-4acoA:
undetectable		 3bjwG-4acoA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du5 PFKB

(Polaromonas sp.
JS666) 		PF00294
(PfkB) 		3 PRO A 127
PHE A  53
LYS A 119
 None
 1.22A 3bjwG-4du5A:
undetectable		 3bjwG-4du5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 PRO A 205
PHE A 155
LYS A 153
 None
 0.95A 3bjwG-4eqvA:
undetectable		 3bjwG-4eqvA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		3 PRO A 749
PHE A 753
LYS A 751
 None
 1.23A 3bjwG-4hsuA:
undetectable		 3bjwG-4hsuA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 PRO A 371
PHE A 101
LYS A 458
 None
 1.15A 3bjwG-4madA:
undetectable		 3bjwG-4madA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9i CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 4

(Homo sapiens) 		PF00385
(Chromo) 		3 PRO X 107
PHE X  67
LYS X  32
 None
 1.14A 3bjwG-4o9iX:
undetectable		 3bjwG-4o9iX:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12157
(DUF3591) 		3 PRO A 756
PHE A 480
LYS A 559
 None
 1.21A 3bjwG-4oy2A:
undetectable		 3bjwG-4oy2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pri TK3 TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO E  25
PHE E 115
LYS E   2
 None
 1.21A 3bjwG-4priE:
undetectable		 3bjwG-4priE:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		3 PRO A 546
PHE A 563
LYS A 547
 None
 1.27A 3bjwG-4qdrA:
undetectable		 3bjwG-4qdrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		3 PRO A 575
PHE A 549
LYS A 523
 None
 1.25A 3bjwG-4qdrA:
undetectable		 3bjwG-4qdrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 PRO A 563
PHE A 554
LYS A 556
 None
 1.26A 3bjwG-4rmfA:
undetectable		 3bjwG-4rmfA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 PRO A 163
PHE A 139
LYS A 160
 None
 1.18A 3bjwG-4xb3A:
undetectable		 3bjwG-4xb3A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xch S-RIBOSYLHOMOCYSTEIN
E LYASE

(Streptococcus
suis) 		PF02664
(LuxS) 		3 PRO A  46
PHE A 155
LYS A  18
 None
 1.14A 3bjwG-4xchA:
undetectable		 3bjwG-4xchA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C

(Homo sapiens) 		PF00225
(Kinesin) 		3 PRO A 284
PHE A 311
LYS A 286
 None
 1.28A 3bjwG-4y05A:
undetectable		 3bjwG-4y05A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		3 PRO A 299
PHE A 286
LYS A 303
 None
 1.21A 3bjwG-5dldA:
undetectable		 3bjwG-5dldA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PRO A 106
PHE A 101
LYS A 104
 None
 1.24A 3bjwG-5eioA:
undetectable		 3bjwG-5eioA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5

(Homo sapiens) 		no annotation 3 PRO A 279
PHE A 397
LYS A 277
 None
P1L  A 371 ( 4.6A)
None
 1.06A 3bjwG-5emwA:
undetectable		 3bjwG-5emwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		3 PRO A 153
PHE A 148
LYS A 155
 None
HEM  A1475 (-4.8A)
None
 1.28A 3bjwG-5fygA:
undetectable		 3bjwG-5fygA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5z MHC CLASS I ANTIGEN

(Ctenopharyngodon
idella) 		no annotation 3 PRO A 191
PHE A 275
LYS A 189
 None
 1.07A 3bjwG-5h5zA:
undetectable		 3bjwG-5h5zA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd9 ENCAPSIDATION
PROTEIN

(Bacillus virus
phi29) 		PF05894
(Podovirus_Gp16) 		3 PRO A   9
PHE A   6
LYS A  30
 None
 1.26A 3bjwG-5hd9A:
undetectable		 3bjwG-5hd9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1t TORSIN-1A

(Homo sapiens) 		PF06309
(Torsin) 		3 PRO A  92
PHE A 203
LYS A  94
 None
 1.27A 3bjwG-5j1tA:
undetectable		 3bjwG-5j1tA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 URACIL-DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		3 PRO D 187
PHE D 284
LYS D 302
 None
 0.97A 3bjwG-5jk7D:
undetectable		 3bjwG-5jk7D:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		3 PRO A 412
PHE A 349
LYS A 407
 None
 1.21A 3bjwG-5k8sA:
undetectable		 3bjwG-5k8sA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		3 PRO A 347
PHE A 121
LYS A 345
 None
 1.28A 3bjwG-5m28A:
undetectable		 3bjwG-5m28A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		3 PRO A 376
PHE A 581
LYS A 585
 None
 1.24A 3bjwG-5mq6A:
1.6		 3bjwG-5mq6A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 PRO A 352
PHE A 356
LYS A 354
 None
 1.14A 3bjwG-5mswA:
undetectable		 3bjwG-5mswA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		3 PRO A1846
PHE A1800
LYS A1810
 None
 1.11A 3bjwG-5mv9A:
undetectable		 3bjwG-5mv9A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv6 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 3

(Methylophaga
aminisulfidivorans) 		PF00497
(SBP_bac_3) 		3 PRO A 123
PHE A 120
LYS A 221
 None
 1.28A 3bjwG-5sv6A:
undetectable		 3bjwG-5sv6A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PRO A 709
PHE A 650
LYS A 711
 None
 1.21A 3bjwG-5tf0A:
undetectable		 3bjwG-5tf0A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8k P800 REACTION CENTER
CORE PROTEIN

(Heliobacterium
modesticaldum) 		PF00223
(PsaA_PsaB) 		3 PRO A  10
PHE A  15
LYS A  19
 GBF  A1004 (-3.8A)
GBF  A1021 (-3.1A)
None
 1.27A 3bjwG-5v8kA:
2.0		 3bjwG-5v8kA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 PRO A 707
PHE A 648
LYS A 709
 None
 1.25A 3bjwG-5xxoA:
undetectable		 3bjwG-5xxoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S16,
PUTATIVE

(Trichomonas
vaginalis) 		PF00380
(Ribosomal_S9) 		3 PRO Q 123
PHE Q 126
LYS Q 124
 C  21412 ( 4.3A)
None
A  21411 ( 2.8A)
 1.23A 3bjwG-5xyiQ:
undetectable		 3bjwG-5xyiQ:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 3 PRO A 553
PHE A 550
LYS A 557
 None
 1.13A 3bjwG-5yfbA:
undetectable		 3bjwG-5yfbA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens) 		no annotation 3 PRO A 161
PHE A 111
LYS A 139
 None
 0.53A 3bjwG-5yq5A:
undetectable		 3bjwG-5yq5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 3 PRO A 197
PHE A 188
LYS A 192
 None
 1.26A 3bjwG-6bngA:
undetectable		 3bjwG-6bngA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 3 PRO A 318
PHE A 299
LYS A 320
 None
 1.27A 3bjwG-6brkA:
undetectable		 3bjwG-6brkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 3 PRO A 615
PHE A 537
LYS A 613
 None
 1.25A 3bjwG-6cipA:
undetectable		 3bjwG-6cipA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 3 PRO A 449
PHE A 455
LYS A 451
 None
 1.26A 3bjwG-6d14A:
undetectable		 3bjwG-6d14A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 PRO C 167
PHE C 162
LYS C 164
 None
 1.10A 3bjwG-6g2jC:
undetectable		 3bjwG-6g2jC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 3 PRO E 322
PHE E 228
LYS E 233
 None
 1.26A 3bjwG-6gsaE:
undetectable		 3bjwG-6gsaE:
undetectable