SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_F_SVRF509_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cij | PROTEIN (HALOALKANEDEHALOGENASE) (Xanthobacterautotrophicus) |
PF00561(Abhydrolase_1) | 4 | TYR A 63PRO A 134PHE A 243TRP A 244 | None | 1.48A | 3bjwD-1cijA:undetectable | 3bjwD-1cijA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dtx | ALPHA-DENDROTOXIN (Dendroaspisangusticeps) |
PF00014(Kunitz_BPTI) | 4 | LYS A 2TYR A 25ASN A 26LYS A 30 | PCA A 1 ( 2.9A)NoneNoneNone | 1.42A | 3bjwD-1dtxA:undetectable | 3bjwD-1dtxA:17.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gmz | PHOSPHOLIPASE A2 (Bothropspirajai) |
PF00068(Phospholip_A2_1) | 4 | LYS A 15TYR A 103ASN A 104LYS A 105 | None | 0.96A | 3bjwD-1gmzA:19.7 | 3bjwD-1gmzA:57.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1god | PROTEIN(PHOSPHOLIPASE A2) (Cerrophidiongodmani) |
PF00068(Phospholip_A2_1) | 4 | LYS A 16TYR A 113ASN A 114PRO A 121 | None | 0.99A | 3bjwD-1godA:19.8 | 3bjwD-1godA:56.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hle | HORSE LEUKOCYTEELASTASE INHIBITOR (Equus caballus) |
PF00079(Serpin) | 4 | TYR A 222LYS A 224LYS A 225PRO A 228 | None | 1.29A | 3bjwD-1hleA:undetectable | 3bjwD-1hleA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | TYR A 268PRO A 154PHE A 222TRP A 177 | None | 1.42A | 3bjwD-1j5sA:undetectable | 3bjwD-1j5sA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1np7 | DNA PHOTOLYASE (Synechocystissp. PCC 6803) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | TYR A 236PRO A 254PHE A 62TRP A 255 | FAD A 500 (-4.5A)NoneNoneNone | 1.36A | 3bjwD-1np7A:undetectable | 3bjwD-1np7A:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvb | BETA-GLYCOSIDASE (Thermosphaeraaggregans) |
PF00232(Glyco_hydro_1) | 4 | LYS A 283ASN A 376LYS A 372PRO A 417 | None | 1.47A | 3bjwD-1qvbA:0.0 | 3bjwD-1qvbA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvb | BETA-GLYCOSIDASE (Thermosphaeraaggregans) |
PF00232(Glyco_hydro_1) | 4 | TYR A 150ASN A 207PHE A 440TRP A 424 | None | 1.46A | 3bjwD-1qvbA:0.0 | 3bjwD-1qvbA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5j | DNA POLYMERASE I (Sulfolobussolfataricus) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | TYR A 460ASN A 160LYS A 157PRO A 138 | NoneNoneSO4 A 883 (-4.5A)SO4 A 883 (-4.4A) | 1.39A | 3bjwD-1s5jA:undetectable | 3bjwD-1s5jA:9.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s8h | PHOSPHOLIPASE A2HOMOLOG (Agkistrodoncontortrix) |
PF00068(Phospholip_A2_1) | 4 | LYS A 16TYR A 113ASN A 114LYS A 115 | None | 0.92A | 3bjwD-1s8hA:20.3 | 3bjwD-1s8hA:62.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tr1 | BETA-GLUCOSIDASE A (Paenibacilluspolymyxa) |
PF00232(Glyco_hydro_1) | 4 | TYR A 120ASN A 165PHE A 414TRP A 398 | NoneNoneGOL A2000 (-3.9A)GOL A2000 (-3.2A) | 1.49A | 3bjwD-1tr1A:undetectable | 3bjwD-1tr1A:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz9 | MANNONATEDEHYDRATASE (Enterococcusfaecalis) |
PF03786(UxuA) | 4 | ASN A 224LYS A 223PRO A 211PHE A 130 | None | 0.85A | 3bjwD-1tz9A:undetectable | 3bjwD-1tz9A:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v87 | DELTEX PROTEIN 2 (Mus musculus) |
PF00097(zf-C3HC4) | 4 | TYR A 74ASN A 78LYS A 79TRP A 101 | None | 1.25A | 3bjwD-1v87A:undetectable | 3bjwD-1v87A:19.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vip | PHOSPHOLIPASE A2 (Daboia russelii) |
PF00068(Phospholip_A2_1) | 4 | LYS A 16TYR A 113LYS A 115PRO A 121 | None | 0.86A | 3bjwD-1vipA:20.8 | 3bjwD-1vipA:49.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzo | HPCE (Thermusthermophilus) |
PF01557(FAA_hydrolase) | 4 | ASN A 240LYS A 82PRO A 40PHE A 41 | None | 1.48A | 3bjwD-1wzoA:undetectable | 3bjwD-1wzoA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zt5 | INSULIN-LIKE GROWTHFACTOR BINDINGPROTEIN 1 (Homo sapiens) |
PF00086(Thyroglobulin_1) | 4 | TYR A 212ASN A 235LYS A 237PRO A 240 | None | 1.39A | 3bjwD-1zt5A:undetectable | 3bjwD-1zt5A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2asn | NITROPHORIN 2 (Rhodniusprolixus) |
PF02087(Nitrophorin) | 4 | TYR X 58ASN X 59LYS X 63LYS X 62 | None | 1.39A | 3bjwD-2asnX:undetectable | 3bjwD-2asnX:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bx7 | DIHYDROOROTATEDEHYDROGENASE (Lactococcuslactis) |
PF01180(DHO_dh) | 4 | ASN A 90LYS A 88PRO A 95PHE A 11 | None | 1.48A | 3bjwD-2bx7A:undetectable | 3bjwD-2bx7A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1g | ACID PHOSPHATASE (Francisellatularensis) |
PF04185(Phosphoesterase) | 4 | TYR A 353PRO A 290PHE A 291TRP A 252 | None | 1.39A | 3bjwD-2d1gA:undetectable | 3bjwD-2d1gA:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 4 | LYS A 245LYS A 241PRO A 205PHE A 203 | NoneNoneNoneGUN A 503 (-3.5A) | 1.50A | 3bjwD-2i9uA:undetectable | 3bjwD-2i9uA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4d | CRYPTOCHROME DASH (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | TYR A 272PRO A 290PHE A 97TRP A 291 | FAD A1498 (-4.6A)NoneNoneNone | 1.39A | 3bjwD-2j4dA:undetectable | 3bjwD-2j4dA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oq2 | PHOSPHOADENOSINEPHOSPHOSULFATEREDUCTASE (Saccharomycescerevisiae) |
PF01507(PAPS_reduct) | 4 | LYS A 95ASN A 202PRO A 30TRP A 190 | None | 1.13A | 3bjwD-2oq2A:undetectable | 3bjwD-2oq2A:16.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qhe | PHOSPHOLIPASE A2 (Echis carinatus) |
PF00068(Phospholip_A2_1) | 4 | LYS A 16TYR A 113ASN A 114PRO A 121 | None | 1.29A | 3bjwD-2qheA:22.8 | 3bjwD-2qheA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qhe | PHOSPHOLIPASE A2 (Echis carinatus) |
PF00068(Phospholip_A2_1) | 4 | LYS A 116PRO A 121PHE A 124TRP A 125 | None | 0.96A | 3bjwD-2qheA:22.8 | 3bjwD-2qheA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qq6 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Rubrobacterxylanophilus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TYR A 269LYS A 292PRO A 315PHE A 337 | None | 1.46A | 3bjwD-2qq6A:undetectable | 3bjwD-2qq6A:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | TYR A 88ASN A 423PRO A 505TRP A 446 | None | 1.21A | 3bjwD-2rdyA:undetectable | 3bjwD-2rdyA:9.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vxr | BOTULINUM NEUROTOXINTYPE G (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | LYS A 943TYR A1142ASN A1134PRO A1131 | GOL A2005 (-4.0A)NoneNoneNone | 1.47A | 3bjwD-2vxrA:undetectable | 3bjwD-2vxrA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y8d | ERYTHROCYTE MEMBRANEPROTEIN 1 (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 4 | TYR A2411PRO A2496PHE A2495TRP A2473 | None | 1.37A | 3bjwD-2y8dA:undetectable | 3bjwD-2y8dA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 4 | LYS A 274ASN A 113PRO A 263TRP A 84 | EDO A 496 (-2.7A)NoneNoneNone | 1.49A | 3bjwD-3b9tA:undetectable | 3bjwD-3b9tA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9f | 5'-NUCLEOTIDASE (Candidaalbicans) |
PF00149(Metallophos) | 4 | TYR A 348ASN A 347LYS A 396PRO A 398 | None | 1.43A | 3bjwD-3c9fA:undetectable | 3bjwD-3c9fA:10.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dih | PHOSPHOLIPASE A2HOMOLOG, AMMODYTIN L (Viperaammodytes) |
PF00068(Phospholip_A2_1) | 4 | LYS A 15TYR A 103ASN A 104LYS A 105 | None | 1.07A | 3bjwD-3dihA:22.0 | 3bjwD-3dihA:64.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dih | PHOSPHOLIPASE A2HOMOLOG, AMMODYTIN L (Viperaammodytes) |
PF00068(Phospholip_A2_1) | 4 | LYS A 15TYR A 103ASN A 104LYS A 106 | None | 1.20A | 3bjwD-3dihA:22.0 | 3bjwD-3dihA:64.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dih | PHOSPHOLIPASE A2HOMOLOG, AMMODYTIN L (Viperaammodytes) |
PF00068(Phospholip_A2_1) | 4 | LYS A 15TYR A 103LYS A 106PHE A 113 | None | 1.43A | 3bjwD-3dihA:22.0 | 3bjwD-3dihA:64.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd2 | SITE-SPECIFIC DNAENDONUCLEASE I-MSOI (Monomastix sp.OKE-1) |
PF00961(LAGLIDADG_1) | 4 | ASN A 109LYS A 106LYS A 105PHE A 48 | None | 1.08A | 3bjwD-3fd2A:undetectable | 3bjwD-3fd2A:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd2 | SITE-SPECIFIC DNAENDONUCLEASE I-MSOI (Monomastix sp.OKE-1) |
PF00961(LAGLIDADG_1) | 4 | ASN A 312LYS A 309LYS A 308PHE A 251 | None | 1.06A | 3bjwD-3fd2A:undetectable | 3bjwD-3fd2A:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkj | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
PF16414(NPC1_N) | 4 | ASN A 198LYS A 196PRO A 207PHE A 209 | HC3 A 253 ( 3.8A)NoneNoneNone | 1.39A | 3bjwD-3gkjA:undetectable | 3bjwD-3gkjA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnr | OS03G0212800 PROTEIN (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | TYR A 131ASN A 177PHE A 460TRP A 444 | TYR A 131 ( 1.3A)ASN A 177 (-0.6A)PHE A 460 (-1.3A)TRP A 444 (-0.5A) | 1.42A | 3bjwD-3gnrA:undetectable | 3bjwD-3gnrA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gq9 | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 4 | ASN A 393LYS A 394PRO A 300PHE A 277 | None | 1.34A | 3bjwD-3gq9A:undetectable | 3bjwD-3gq9A:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icf | SERINE/THREONINE-PROTEIN PHOSPHATASE T (Saccharomycescerevisiae) |
PF00149(Metallophos)PF08321(PPP5) | 4 | ASN A 317LYS A 318PRO A 382PHE A 388 | None | 1.26A | 3bjwD-3icfA:undetectable | 3bjwD-3icfA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j70 | ENVELOPEGLYCOPROTEIN GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 4 | ASN D 392LYS D 362PHE D 396TRP D 400 | None | 1.48A | 3bjwD-3j70D:undetectable | 3bjwD-3j70D:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9e | VP5 (Bluetonguevirus) |
PF00901(Orbi_VP5) | 4 | LYS D 3ASN D 434PRO D 370TRP D 371 | None | 1.31A | 3bjwD-3j9eD:undetectable | 3bjwD-3j9eD:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-PROCESSINGFACTOR 17PRE-MRNA-SPLICINGFACTOR CWF5 (Schizosaccharomycespombe) |
PF01423(LSM)PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 4 | ASN g 83LYS g 82PRO a 20PHE a 54 | None | 1.49A | 3bjwD-3jb9g:undetectable | 3bjwD-3jb9g:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd8 | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
PF02460(Patched)PF12349(Sterol-sensing)PF16414(NPC1_N) | 4 | ASN A 198LYS A 196PRO A 207PHE A 209 | CLR A1325 ( 3.9A)NoneNoneNone | 1.42A | 3bjwD-3jd8A:undetectable | 3bjwD-3jd8A:7.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2i | ACYL-COENZYME ATHIOESTERASE 4 (Homo sapiens) |
PF04775(Bile_Hydr_Trans)PF08840(BAAT_C) | 4 | ASN A 305LYS A 304PRO A 310PHE A 244 | None | 1.38A | 3bjwD-3k2iA:undetectable | 3bjwD-3k2iA:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpp | BOTULINUM NEUROTOXINTYPE G (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | LYS G 943TYR G1142ASN G1134PRO G1131 | None | 1.49A | 3bjwD-3mppG:undetectable | 3bjwD-3mppG:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p1u | SUSD HOMOLOG (Parabacteroidesdistasonis) |
PF12741(SusD-like) | 4 | ASN A 290LYS A 316PRO A 319PHE A 411 | None | 1.33A | 3bjwD-3p1uA:undetectable | 3bjwD-3p1uA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ryk | DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Bacillusanthracis) |
PF00908(dTDP_sugar_isom) | 4 | TYR A 30ASN A 31LYS A 32LYS A 33 | None | 1.15A | 3bjwD-3rykA:undetectable | 3bjwD-3rykA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 4 | TYR A 97ASN A 100LYS A 99PHE A 81 | None | 1.32A | 3bjwD-3vasA:undetectable | 3bjwD-3vasA:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vup | BETA-1,4-MANNANASE (Aplysia kurodai) |
PF00150(Cellulase) | 4 | TYR A 102LYS A 49LYS A 50PHE A 308 | None | 1.46A | 3bjwD-3vupA:undetectable | 3bjwD-3vupA:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuu | ERYTHROCYTE MEMBRANEPROTEIN, PUTATIVE (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 4 | TYR A 337ASN A 339PRO A 344PHE A 346 | None | 1.45A | 3bjwD-3vuuA:undetectable | 3bjwD-3vuuA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfe | CELL SURFACEGLYCOPROTEIN CD200RECEPTOR 4 (Mus musculus) |
PF07686(V-set)PF08205(C2-set_2) | 4 | TYR A 62ASN A 63LYS A 67LYS A 66 | NAG A 690 (-4.9A)NoneNoneNone | 1.25A | 3bjwD-4bfeA:undetectable | 3bjwD-4bfeA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewt | PEPTIDASE,M20/M25/M40 FAMILY (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | TYR A 293ASN A 294PRO A 142PHE A 31 | None | 1.48A | 3bjwD-4ewtA:undetectable | 3bjwD-4ewtA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbq | DNA REPAIR ANDTELOMERE MAINTENANCEPROTEIN NBS1,DNAREPAIR PROTEIN RAD32CHIMERIC PROTEIN (Schizosaccharomycespombe) |
PF00149(Metallophos)PF04152(Mre11_DNA_bind) | 4 | TYR A1260ASN A1261LYS A1265PHE A1205 | None | 1.20A | 3bjwD-4fbqA:undetectable | 3bjwD-4fbqA:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4s | PROTEASOME ASSEMBLYCHAPERONE 2 (Saccharomycescerevisiae) |
PF09754(PAC2) | 4 | TYR P 74ASN P 75LYS P 76LYS P 77 | None | 1.20A | 3bjwD-4g4sP:undetectable | 3bjwD-4g4sP:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gf0 | GLUTATHIONES-TRANSFERASE (Sulfitobactersp. NAS-14.1) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | LYS A 112ASN A 170PRO A 163PHE A 158 | None | 1.33A | 3bjwD-4gf0A:undetectable | 3bjwD-4gf0A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 12 (Thermusthermophilus) |
PF00361(Proton_antipo_M)PF00662(Proton_antipo_N) | 4 | TYR L 297LYS L 293LYS L 292PHE L 425 | None | 1.41A | 3bjwD-4heaL:undetectable | 3bjwD-4heaL:9.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvf | GREEN FLUORESCENTPROTEIN BLFP-Y6 (Branchiostomalanceolatum) |
PF01353(GFP) | 4 | ASN A 150LYS A 180PRO A 74PHE A 67 | None | 1.45A | 3bjwD-4hvfA:undetectable | 3bjwD-4hvfA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hw8 | BACTERIALEXTRACELLULARSOLUTE-BINDINGPROTEIN, PUTATIVE (Staphylococcusaureus) |
PF13416(SBP_bac_8) | 4 | TYR A 158ASN A 159LYS A 160LYS A 161 | None | 1.29A | 3bjwD-4hw8A:undetectable | 3bjwD-4hw8A:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iss | ALLOPHANATEHYDROLASE (Kluyveromyceslactis) |
PF01425(Amidase) | 4 | TYR A 148ASN A 381PRO A 272TRP A 265 | None | 1.42A | 3bjwD-4issA:undetectable | 3bjwD-4issA:11.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3b | M1 FAMILYAMINOPEPTIDASE (Plasmodiumfalciparum) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 4 | TYR A1077ASN A1073PRO A 459PHE A 457 | NoneNoneARG A1101 (-3.9A)None | 1.21A | 3bjwD-4j3bA:undetectable | 3bjwD-4j3bA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3o | OUTER MEMBRANE USHERPROTEIN FIMD (Escherichiacoli) |
PF00577(Usher)PF13953(PapC_C)PF13954(PapC_N) | 4 | TYR D 418ASN D 419LYS D 420PRO D 254 | None | 1.41A | 3bjwD-4j3oD:undetectable | 3bjwD-4j3oD:8.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jge | RED FLUORESCENTPROTEIN BLFP-R5 (Branchiostomalanceolatum) |
PF01353(GFP) | 4 | ASN A 150LYS A 180PRO A 74PHE A 67 | None | 1.41A | 3bjwD-4jgeA:undetectable | 3bjwD-4jgeA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptx | GLYCOSIDE HYDROLASEFAMILY 1 (Halothermothrixorenii) |
PF00232(Glyco_hydro_1) | 4 | TYR A 120ASN A 165PHE A 417TRP A 401 | NoneBGC A 501 (-3.3A)BGC A 501 (-3.8A)BGC A 501 (-3.6A) | 1.43A | 3bjwD-4ptxA:undetectable | 3bjwD-4ptxA:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlz | SJCHGC07024 PROTEIN (Schistosomajaponicum) |
PF00719(Pyrophosphatase) | 4 | LYS A 152TYR A 91PRO A 65PHE A 16 | CO A 404 ( 3.2A)PO4 A 405 (-4.6A)NoneNone | 1.27A | 3bjwD-4qlzA:undetectable | 3bjwD-4qlzA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rm9 | EZRIN (Homo sapiens) |
PF00373(FERM_M)PF00769(ERM)PF09379(FERM_N)PF09380(FERM_C) | 4 | TYR A 270ASN A 210LYS A 211LYS A 212 | None | 1.46A | 3bjwD-4rm9A:undetectable | 3bjwD-4rm9A:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry9 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Verminephrobactereiseniae) |
PF13407(Peripla_BP_4) | 4 | LYS A 270TYR A 324ASN A 325LYS A 327 | None | 1.37A | 3bjwD-4ry9A:undetectable | 3bjwD-4ry9A:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ug4 | CHOLINE SULFATASE (Sinorhizobiummeliloti) |
PF00884(Sulfatase)PF12411(Choline_sulf_C) | 4 | TYR A 123ASN A 75PRO A 52PHE A 312 | None | 1.46A | 3bjwD-4ug4A:undetectable | 3bjwD-4ug4A:12.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wtb | BASIC PHOSPHOLIPASEA2 HOMOLOGBOTHROPSTOXIN-1 (Bothropsjararacussu) |
PF00068(Phospholip_A2_1) | 4 | LYS A 15TYR A 103ASN A 104LYS A 105 | None | 1.02A | 3bjwD-4wtbA:20.5 | 3bjwD-4wtbA:56.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wtb | BASIC PHOSPHOLIPASEA2 HOMOLOGBOTHROPSTOXIN-1 (Bothropsjararacussu) |
PF00068(Phospholip_A2_1) | 4 | LYS A 15TYR A 103ASN A 104PHE A 114 | None | 0.98A | 3bjwD-4wtbA:20.5 | 3bjwD-4wtbA:56.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr7 | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3 (Saccharomycescerevisiae) |
no annotation | 4 | TYR G 812ASN G 813LYS G 815PHE L 552 | None | 0.93A | 3bjwD-4xr7G:undetectable | 3bjwD-4xr7G:10.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1y | GALECTIN-1 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 4 | ASN A 33LYS A 43PRO A 47PHE A 79 | NoneCSO A 42 ( 3.6A)NoneNone | 1.41A | 3bjwD-4y1yA:undetectable | 3bjwD-4y1yA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeh | LECTIN (Cicer arietinum) |
PF00045(Hemopexin) | 4 | LYS A 136ASN A 81LYS A 103PRO A 101 | None | 1.47A | 3bjwD-4yehA:undetectable | 3bjwD-4yehA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhb | ANKYRINREPEAT-CONTAININGPROTEIN (Legionellapneumophila) |
PF12796(Ank_2) | 4 | TYR A 50ASN A 83LYS A 86PHE A 102 | None | 1.31A | 3bjwD-4zhbA:undetectable | 3bjwD-4zhbA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpi | PUTATIVEOXIDASE/HYDROXYLASE (Streptomyceshygroscopicus) |
PF05721(PhyH) | 4 | ASN A 105LYS A 161PRO A 134PHE A 229 | None | 0.96A | 3bjwD-4zpiA:undetectable | 3bjwD-4zpiA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c24 | HIV-1 REVERSETRANSCRIPTASE, P51SUBUNIT (Humanimmunodeficiencyvirus 1) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | LYS B 166PRO B 150PHE B 77TRP B 153 | None | 1.32A | 3bjwD-5c24B:undetectable | 3bjwD-5c24B:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2m | PREDICTED PROTEIN (Nematostellavectensis) |
PF14517(Tachylectin) | 4 | ASN A 230LYS A 215LYS A 216TRP A 192 | None | 1.39A | 3bjwD-5c2mA:undetectable | 3bjwD-5c2mA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cg0 | BETA-GLUCOSIDASE (Spodopterafrugiperda) |
PF00232(Glyco_hydro_1) | 4 | TYR A 141ASN A 186PHE A 460TRP A 444 | NoneNoneTRS A 603 (-4.1A)TRS A 603 ( 4.2A) | 1.45A | 3bjwD-5cg0A:undetectable | 3bjwD-5cg0A:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgl | NICR (Pseudomonasputida) |
PF00440(TetR_N) | 4 | TYR A 94ASN A 93LYS A 90LYS A 89 | None | 1.36A | 3bjwD-5fglA:undetectable | 3bjwD-5fglA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4x | SH3 AND MULTIPLEANKYRIN REPEATDOMAINS PROTEIN 3 (Rattusnorvegicus) |
PF12796(Ank_2)PF16511(FERM_f0) | 4 | TYR A 53ASN A 52PRO A 141PHE A 119 | EDO A1354 (-4.6A)NoneNoneNone | 1.49A | 3bjwD-5g4xA:undetectable | 3bjwD-5g4xA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 4 | TYR A 148ASN A 381PRO A 272TRP A 265 | None | 1.42A | 3bjwD-5i8iA:undetectable | 3bjwD-5i8iA:4.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idi | 1,4-BETA-D-GLUCANGLUCOHYDROLASE (Thermotoganeapolitana) |
PF00232(Glyco_hydro_1) | 4 | TYR A 118ASN A 163PHE A 412TRP A 396 | NoneNoneACT A 501 ( 4.0A)ACT A 501 (-3.4A) | 1.44A | 3bjwD-5idiA:undetectable | 3bjwD-5idiA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8b | 8-AMINO-3,8-DIDEOXY-ALPHA-D-MANNO-OCTULOSONATE TRANSAMINASE (Shewanellaoneidensis) |
PF01041(DegT_DnrJ_EryC1) | 4 | ASN A 261LYS A 262PRO A 2PHE A 4 | None CL A 503 (-3.0A)NoneNone | 1.22A | 3bjwD-5k8bA:undetectable | 3bjwD-5k8bA:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE BETASUBUNITACETOPHENONECARBOXYLASE DELTASUBUNIT (Aromatoleumaromaticum) |
PF02538(Hydantoinase_B)PF08882(Acetone_carb_G) | 4 | TYR C 36LYS C 37LYS C 38PRO A 648 | None | 1.44A | 3bjwD-5l9wC:undetectable | 3bjwD-5l9wC:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lfr | MYELIN-ASSOCIATEDGLYCOPROTEIN (Mus musculus) |
PF08205(C2-set_2)PF13927(Ig_3) | 4 | ASN A 266LYS A 237PRO A 206PHE A 204 | None | 1.17A | 3bjwD-5lfrA:undetectable | 3bjwD-5lfrA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m86 | TA1207 (Thermoplasmaacidophilum) |
no annotation | 4 | TYR A 214LYS A 204PRO A 42PHE A 52 | None | 1.44A | 3bjwD-5m86A:undetectable | 3bjwD-5m86A:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlc | 50S RIBOSOMALPROTEIN L3,CHLOROPLASTIC (Spinaciaoleracea) |
PF00297(Ribosomal_L3) | 4 | ASN E 301LYS E 296PRO E 294PHE E 191 | None C A2789 ( 2.7A)NoneNone | 1.46A | 3bjwD-5mlcE:undetectable | 3bjwD-5mlcE:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n8o | DNA HELICASE I (Escherichiacoli) |
PF07057(TraI)PF08751(TrwC)PF13604(AAA_30) | 4 | TYR A 16PRO A 154PHE A 234TRP A 277 | None | 1.29A | 3bjwD-5n8oA:undetectable | 3bjwD-5n8oA:4.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9h | C5A ANAPHYLATOXINCHEMOTACTIC RECEPTOR1 (Homo sapiens) |
no annotation | 4 | TYR A 181LYS A 185PRO A 103PHE A 104 | None | 1.45A | 3bjwD-5o9hA:undetectable | 3bjwD-5o9hA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogz | - (-) |
no annotation | 4 | TYR A 120ASN A 165PHE A 418TRP A 402 | None | 1.48A | 3bjwD-5ogzA:undetectable | 3bjwD-5ogzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5owc | - (-) |
no annotation | 4 | TYR A 103LYS A 106PRO A 111PHE A 113 | PEG A 205 ( 4.2A)NoneNoneNone | 1.47A | 3bjwD-5owcA:18.7 | 3bjwD-5owcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uam | ULVAN LYASE-PL25 (Pseudoalteromonassp. PLSV) |
PF15892(BNR_4) | 4 | LYS A 432TYR A 466LYS A 464PRO A 84 | None | 1.46A | 3bjwD-5uamA:undetectable | 3bjwD-5uamA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgz | BETA-GLYCOSIDASE (unculturedmicroorganism) |
no annotation | 4 | TYR A 124ASN A 169PHE A 419TRP A 403 | NoneNoneGOL A 501 (-4.3A)GOL A 501 (-3.5A) | 1.42A | 3bjwD-5xgzA:undetectable | 3bjwD-5xgzA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y5a | KLLA0F20702P (Kluyveromyceslactis) |
no annotation | 4 | ASN A 471LYS A 470PRO A 526PHE A 524 | None | 1.30A | 3bjwD-5y5aA:undetectable | 3bjwD-5y5aA:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 4 | LYS A 79TYR A1692ASN A1695PHE A1610 | None | 1.02A | 3bjwD-5zalA:undetectable | 3bjwD-5zalA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epe | PROTEASOME (PROSOME,MACROPAIN) 26SSUBUNIT, NON-ATPASE,7 (PREDICTED) (Rattusnorvegicus) |
no annotation | 4 | LYS U 84ASN U 77PRO U 57PHE U 69 | None | 1.20A | 3bjwD-6epeU:undetectable | 3bjwD-6epeU:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gdt | - (-) |
no annotation | 4 | LYS A 510ASN A 496PRO A 484PHE A 62 | None | 1.38A | 3bjwD-6gdtA:undetectable | 3bjwD-6gdtA:undetectable |