SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_F_SVRF502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		4 ILE A 266
PRO A 232
PHE A 244
PRO A 234
 None
 0.91A 3bjwC-1a0cA:
0.0		 3bjwC-1a0cA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 ILE A 264
PRO A 230
PHE A 242
PRO A 232
 None
 1.00A 3bjwC-1a0dA:
0.0		 3bjwC-1a0dA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		4 ILE A 266
PRO A 232
PHE A 244
PRO A 234
 None
 0.94A 3bjwC-1a0eA:
0.0		 3bjwC-1a0eA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 ILE A 459
SER A 460
PRO A 461
PHE A 466
 None
 1.35A 3bjwC-1a4sA:
0.0		 3bjwC-1a4sA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b55 TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF00169
(PH)
PF00779
(BTK) 		4 ILE A  79
PRO A  99
PHE A 114
PRO A 101
 None
 1.17A 3bjwC-1b55A:
0.0		 3bjwC-1b55A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 ILE A 184
PRO A 137
PHE A 134
PRO A 135
 None
 1.23A 3bjwC-1dr9A:
0.0		 3bjwC-1dr9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A  63
SER A  62
PHE A 112
PRO A  86
 None
 1.39A 3bjwC-1hfuA:
0.0		 3bjwC-1hfuA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 ILE A  85
SER A  38
PRO A  37
PHE A  35
 None
 1.14A 3bjwC-1j1uA:
0.0		 3bjwC-1j1uA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ILE A 409
SER A 256
PRO A 257
PHE A 241
 None
None
None
TRP  A 601 (-3.9A)
 1.27A 3bjwC-1k0gA:
0.0		 3bjwC-1k0gA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 ILE A 226
SER A 223
PRO A  19
PHE A  17
 None
DND  A 301 ( 4.7A)
None
DND  A 301 (-4.6A)
 0.98A 3bjwC-1kqoA:
undetectable		 3bjwC-1kqoA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ILE A 484
SER A 447
PRO A 448
PRO A 450
 None
 1.40A 3bjwC-1l0wA:
undetectable		 3bjwC-1l0wA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 SER A 228
PRO A 229
PHE A 221
PRO A 222
 None
 1.41A 3bjwC-1mjfA:
undetectable		 3bjwC-1mjfA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 ILE A 133
SER A 134
PRO A 135
PHE A 136
 None
 1.12A 3bjwC-1pweA:
undetectable		 3bjwC-1pweA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 ILE A 334
SER A 330
PRO A 287
PRO A 285
 None
 1.39A 3bjwC-1qyiA:
undetectable		 3bjwC-1qyiA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE

(Drosophila
melanogaster) 		PF01135
(PCMT) 		4 ILE A  53
SER A  41
PRO A  42
PRO A  45
 None
 1.12A 3bjwC-1r18A:
undetectable		 3bjwC-1r18A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		4 ILE A 212
SER A 193
PRO A 194
PRO A 186
 None
 1.22A 3bjwC-1udxA:
undetectable		 3bjwC-1udxA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		4 ILE A 522
PRO A 372
PHE A 371
PRO A 370
 None
 1.31A 3bjwC-1uusA:
undetectable		 3bjwC-1uusA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 ILE A 240
SER A 235
PHE A 370
PRO A 369
 None
 1.36A 3bjwC-1vg0A:
undetectable		 3bjwC-1vg0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 ILE A  89
SER A  87
PHE A  20
PRO A  86
 None
 1.25A 3bjwC-1vk1A:
undetectable		 3bjwC-1vk1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		4 ILE A  78
SER A  74
PRO A  75
PRO A 409
 None
 1.32A 3bjwC-1yxaA:
undetectable		 3bjwC-1yxaA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C

(Homo sapiens) 		PF03770
(IPK) 		4 ILE A 608
SER A 609
PRO A 610
PHE A 611
 None
 1.16A 3bjwC-2a98A:
undetectable		 3bjwC-2a98A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 ILE A 863
SER A 864
PRO A 865
PHE A 866
 None
 1.08A 3bjwC-2aqxA:
undetectable		 3bjwC-2aqxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F) 		PF00541
(Adeno_knob) 		4 ILE A 236
SER A 237
PRO A 238
PRO A 240
 None
 1.40A 3bjwC-2bzuA:
undetectable		 3bjwC-2bzuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1u DI-HAEM CYTOCHROME C
PEROXIDASE

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 ILE A  63
SER A  64
PRO A  55
PHE A  53
 HEC  A 401 (-4.6A)
None
None
None
 1.35A 3bjwC-2c1uA:
undetectable		 3bjwC-2c1uA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cry KIN OF IRRE-LIKE
PROTEIN 3

(Homo sapiens) 		PF13927
(Ig_3) 		4 ILE A  37
SER A  39
PHE A 100
PRO A  41
 None
 1.40A 3bjwC-2cryA:
undetectable		 3bjwC-2cryA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 ILE A 163
SER A 164
PHE A 193
PRO A 192
 None
 1.39A 3bjwC-2cuyA:
0.9		 3bjwC-2cuyA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ILE A 116
SER A 117
PRO A 211
PRO A 213
 None
 1.40A 3bjwC-2cvtA:
undetectable		 3bjwC-2cvtA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C

(;
Homo sapiens) 		no annotation 4 ILE A 466
SER A 468
PRO B 164
PRO B 162
 None
 1.31A 3bjwC-2gkwA:
undetectable		 3bjwC-2gkwA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 ILE A 375
SER A 339
PRO A 408
PHE A 407
 None
 1.35A 3bjwC-2jf4A:
undetectable		 3bjwC-2jf4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 ILE B 241
SER B 237
PRO B 239
PRO B 235
 None
 1.37A 3bjwC-2pffB:
1.1		 3bjwC-2pffB:
4.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 ILE A  10
PRO A  18
PHE A  19
PRO A  20
 None
 0.33A 3bjwC-2qheA:
22.8		 3bjwC-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		4 ILE A 237
SER A 229
PRO A 230
PRO A 232
 None
None
PG4  A 358 (-4.3A)
None
 1.13A 3bjwC-2rauA:
undetectable		 3bjwC-2rauA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		4 ILE A 300
SER A 299
PHE A 298
PRO A 297
 None
 1.19A 3bjwC-2x1cA:
undetectable		 3bjwC-2x1cA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A  56
SER A  52
PRO A  53
PHE A  50
 None
 1.34A 3bjwC-2z9sA:
undetectable		 3bjwC-2z9sA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii) 		PF01868
(UPF0086) 		4 ILE A  94
SER A  93
PHE A  63
PRO A  89
 None
None
GOL  A 132 ( 4.5A)
NO3  A 130 ( 4.6A)
 1.17A 3bjwC-2zaeA:
undetectable		 3bjwC-2zaeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		4 ILE A 128
PRO A 126
PHE A  33
PRO A 118
 None
 1.37A 3bjwC-3afoA:
undetectable		 3bjwC-3afoA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		4 ILE A 381
SER A 228
PRO A 229
PHE A 213
 None
 1.23A 3bjwC-3h9mA:
undetectable		 3bjwC-3h9mA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		4 ILE A  60
SER A  56
PRO A  57
PHE A 153
 None
 1.31A 3bjwC-3hj6A:
undetectable		 3bjwC-3hj6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 647
SER B 644
PRO B 645
PHE B 945
 None
 1.38A 3bjwC-3hkzB:
undetectable		 3bjwC-3hkzB:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		4 ILE A 146
SER A 147
PRO A 148
PRO A 188
 None
 1.30A 3bjwC-3ho6A:
undetectable		 3bjwC-3ho6A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		4 ILE A 332
SER A 300
PHE A 223
PRO A 297
 None
 1.19A 3bjwC-3i16A:
2.1		 3bjwC-3i16A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		4 ILE A 108
PRO A 101
PHE A  99
PRO A  98
 None
 1.00A 3bjwC-3khzA:
1.0		 3bjwC-3khzA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 SER A 259
PRO A 261
PHE A 190
PRO A 263
 None
 1.18A 3bjwC-3kmuA:
undetectable		 3bjwC-3kmuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 ILE A  49
SER A  50
PRO A  51
PRO A  53
 None
 1.36A 3bjwC-3m6xA:
undetectable		 3bjwC-3m6xA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A  83
SER A  82
PRO A  86
PRO A  88
 None
CMP  A 623 (-2.7A)
None
None
 1.42A 3bjwC-3mzhA:
undetectable		 3bjwC-3mzhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 114
PRO A  73
PHE A  70
PRO A  69
 None
 1.30A 3bjwC-3ogrA:
undetectable		 3bjwC-3ogrA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbc PEROXIREDOXIN TSA1

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A  51
SER A  47
PRO A  48
PHE A  45
 None
 1.34A 3bjwC-3sbcA:
undetectable		 3bjwC-3sbcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 ILE A 161
SER A 483
PRO A 484
PHE A 486
 None
None
SO4  A 547 (-4.5A)
None
 1.35A 3bjwC-3sqlA:
undetectable		 3bjwC-3sqlA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		4 ILE A 332
SER A 342
PRO A 343
PRO A 347
 None
 1.29A 3bjwC-3uk6A:
undetectable		 3bjwC-3uk6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 ILE X 299
SER X 205
PRO X 204
PRO X 197
 None
 1.25A 3bjwC-3utnX:
undetectable		 3bjwC-3utnX:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 ILE A 142
SER A 143
PRO A 144
PRO A 196
 None
 1.39A 3bjwC-4a0hA:
undetectable		 3bjwC-4a0hA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ILE A 462
SER A  21
PRO A  20
PRO A 513
 None
 1.11A 3bjwC-4bziA:
undetectable		 3bjwC-4bziA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz1 KYNURENINE
FORMAMIDASE

(Bacillus
anthracis) 		PF04199
(Cyclase) 		4 ILE A  49
SER A 200
PRO A 201
PRO A 191
 None
 1.18A 3bjwC-4cz1A:
undetectable		 3bjwC-4cz1A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 ILE D 193
SER D 187
PRO D 188
PRO D 215
 None
 1.34A 3bjwC-4djeD:
undetectable		 3bjwC-4djeD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 ILE D 217
SER D 216
PRO D 215
PRO D 188
 None
 1.30A 3bjwC-4djeD:
undetectable		 3bjwC-4djeD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 ILE A 150
SER A 151
PRO A 152
PRO A 156
 None
 1.29A 3bjwC-4dngA:
undetectable		 3bjwC-4dngA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 ILE A  34
SER A  30
PRO A  31
PHE A 364
 None
 1.39A 3bjwC-4dteA:
undetectable		 3bjwC-4dteA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		4 ILE A 109
PRO A 182
PHE A 154
PRO A 156
 None
 1.18A 3bjwC-4emeA:
undetectable		 3bjwC-4emeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsn GLUTATHIONE
S-TRANSFERASE E2

(Anopheles
gambiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 163
SER A 164
PHE A 108
PRO A  14
 None
None
GSH  A 301 (-4.6A)
GSH  A 301 (-4.3A)
 1.32A 3bjwC-4gsnA:
undetectable		 3bjwC-4gsnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt7 IG EPSILON CHAIN C
REGION

(Homo sapiens) 		PF07654
(C1-set) 		4 ILE A 474
SER A 475
PRO A 345
PHE A 346
 None
 1.34A 3bjwC-4gt7A:
undetectable		 3bjwC-4gt7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN
HEMAGGLUTININ HA1

(Homo sapiens;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  53
SER H  31
PRO A 145
PHE H  29
 None
 1.40A 3bjwC-4hfuH:
undetectable		 3bjwC-4hfuH:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi7 GI20122

(Drosophila
mojavensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 165
SER A 166
PHE A 108
PRO A  14
 None
None
GSH  A 301 (-4.6A)
GSH  A 301 (-4.6A)
 1.34A 3bjwC-4hi7A:
undetectable		 3bjwC-4hi7A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz4 GLUTATHIONE-S-TRANSF
ERASE

(Actinobacillus
pleuropneumoniae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A 188
SER A 163
PHE A 164
PRO A 165
 None
 1.42A 3bjwC-4hz4A:
undetectable		 3bjwC-4hz4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 ILE A 215
SER A 214
PRO A 213
PRO A 188
 None
 1.40A 3bjwC-4idmA:
undetectable		 3bjwC-4idmA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8

(Homo sapiens) 		PF00782
(DSPc) 		4 ILE A 283
SER A 284
PRO A 285
PHE A 287
 None
 1.11A 3bjwC-4jmkA:
undetectable		 3bjwC-4jmkA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Xylanimonas
cellulosilytica) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		4 ILE A 291
SER A 231
PRO A 292
PRO A 295
 None
 1.39A 3bjwC-4lpqA:
undetectable		 3bjwC-4lpqA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		4 ILE A 268
PRO A 176
PHE A 200
PRO A 199
 None
 1.36A 3bjwC-4mhbA:
undetectable		 3bjwC-4mhbA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 ILE A 675
SER A 706
PRO A 707
PHE A 709
 None
 1.28A 3bjwC-4mhcA:
undetectable		 3bjwC-4mhcA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE

(Alicyclobacillus
acidocaldarius) 		PF00016
(RuBisCO_large) 		4 ILE A 339
SER A 336
PRO A 335
PRO A 302
 None
 1.20A 3bjwC-4nasA:
undetectable		 3bjwC-4nasA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4png LD04004P

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 165
SER A 166
PHE A 108
PRO A  14
 None
None
GSF  A2001 (-3.8A)
GSF  A2001 (-4.6A)
 1.35A 3bjwC-4pngA:
undetectable		 3bjwC-4pngA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 481
SER A 480
PRO A 479
PRO A 502
 None
 1.41A 3bjwC-4q1vA:
undetectable		 3bjwC-4q1vA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		4 ILE A 339
SER A 340
PRO A 341
PRO A  88
 None
TRP  A 503 (-2.8A)
None
TRP  A 503 (-4.0A)
 1.10A 3bjwC-4r33A:
undetectable		 3bjwC-4r33A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ILE A 483
SER A 475
PRO A 476
PRO A 478
 None
 1.18A 3bjwC-4tweA:
0.5		 3bjwC-4tweA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usp CCL2 LECTIN

(Coprinopsis
cinerea) 		no annotation 4 ILE A  76
SER A  67
PRO A  68
PRO A  72
 None
 1.42A 3bjwC-4uspA:
undetectable		 3bjwC-4uspA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		4 ILE A 247
PRO A 212
PHE A 213
PRO A 215
 EDO  A 302 (-4.7A)
None
None
None
 1.16A 3bjwC-4xgnA:
undetectable		 3bjwC-4xgnA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhz PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		4 SER A 795
PRO A 796
PHE A 878
PRO A 886
 None
 1.26A 3bjwC-4xhzA:
undetectable		 3bjwC-4xhzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		4 ILE A  56
SER A  60
PRO A  61
PRO A  11
 None
 1.07A 3bjwC-4z7lA:
undetectable		 3bjwC-4z7lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 101
SER A 103
PHE A 104
PRO A 105
 None
 1.37A 3bjwC-5ceeA:
undetectable		 3bjwC-5ceeA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 ILE A 168
SER A  53
PRO A  54
PRO A  57
 None
 1.37A 3bjwC-5e3cA:
undetectable		 3bjwC-5e3cA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtq LUCIFERIN
REGENERATING ENZYME

(Photinus
pyralis) 		PF08450
(SGL) 		4 ILE A 174
SER A 176
PRO A 211
PHE A 227
 None
MPD  A 405 ( 3.7A)
None
MPD  A 405 (-3.6A)
 1.38A 3bjwC-5gtqA:
undetectable		 3bjwC-5gtqA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h16 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF01467
(CTP_transf_like) 		4 ILE A 133
SER A 130
PRO A  14
PHE A  12
 None
CIT  A 201 (-2.6A)
None
CIT  A 201 (-4.0A)
 0.94A 3bjwC-5h16A:
undetectable		 3bjwC-5h16A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC

(Escherichia
coli) 		PF09344
(Cas_CT1975) 		4 ILE D 309
SER D 308
PRO D 307
PHE D 304
 None
 1.15A 3bjwC-5h9fD:
undetectable		 3bjwC-5h9fD:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 ILE B 296
SER B 293
PHE B 332
PRO B 290
 None
 1.20A 3bjwC-5hdfB:
undetectable		 3bjwC-5hdfB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 ILE A 650
PRO A 652
PHE A 659
PRO A 110
 None
None
None
ADP  A 803 (-4.2A)
 1.34A 3bjwC-5hmpA:
0.9		 3bjwC-5hmpA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 114
PRO A  73
PHE A  70
PRO A  69
 None
 1.17A 3bjwC-5ihrA:
undetectable		 3bjwC-5ihrA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 4 ILE F 662
SER F 661
PHE F 657
PRO F 619
 None
None
ATP  F 902 (-3.9A)
None
 1.31A 3bjwC-5it5F:
undetectable		 3bjwC-5it5F:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A 117
SER A 119
PHE A 120
PRO A 121
 None
 1.38A 3bjwC-5k6zA:
undetectable		 3bjwC-5k6zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgk IG EPSILON CHAIN C
REGION

(Homo sapiens) 		PF07654
(C1-set) 		4 ILE A 474
SER A 475
PRO A 345
PHE A 346
 None
 1.27A 3bjwC-5lgkA:
undetectable		 3bjwC-5lgkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ILE A 311
PRO A 398
PHE A 400
PRO A 395
 None
None
ZN  A 511 ( 4.7A)
None
 1.30A 3bjwC-5m8tA:
0.3		 3bjwC-5m8tA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ILE B 224
SER B 220
PHE B 180
PRO B 219
 None
 1.21A 3bjwC-5swiB:
undetectable		 3bjwC-5swiB:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkw TYPE II SECRETION
SYSTEM PROTEIN L

(Klebsiella
pneumoniae) 		PF05134
(T2SSL) 		4 SER A  47
PRO A  48
PHE A  49
PRO A  50
 None
 1.17A 3bjwC-5tkwA:
undetectable		 3bjwC-5tkwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 ILE A 419
SER A 438
PRO A 439
PHE A 441
 None
 1.29A 3bjwC-5wblA:
undetectable		 3bjwC-5wblA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		4 ILE A  89
SER A  87
PHE A  20
PRO A  86
 None
 1.30A 3bjwC-5x0eA:
undetectable		 3bjwC-5x0eA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys2 ENVELOPE
GLYCOPROTEIN
B,ENVELOPE
GLYCOPROTEIN B

(Suid
alphaherpesvirus
1) 		no annotation 4 ILE A 540
SER A 541
PRO A  72
PRO A  70
 None
 1.06A 3bjwC-5ys2A:
undetectable		 3bjwC-5ys2A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys6 PRV GLYCOPROTEN B

(Suid
alphaherpesvirus
1) 		no annotation 4 ILE A 598
SER A 599
PRO A 130
PRO A 128
 None
 1.03A 3bjwC-5ys6A:
undetectable		 3bjwC-5ys6A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 4 ILE A 170
SER A 167
PRO A 166
PRO A 164
 None
 1.39A 3bjwC-5ysmA:
undetectable		 3bjwC-5ysmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 4 SER B 531
PRO B 533
PHE B 534
PRO B 529
 None
 1.38A 3bjwC-6b4jB:
undetectable		 3bjwC-6b4jB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 4 ILE A 815
SER A 816
PRO A 818
PHE A 820
 None
 1.39A 3bjwC-6bf6A:
undetectable		 3bjwC-6bf6A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 ILE M  39
PRO N  22
PHE N  23
PRO N  24
 None
 1.33A 3bjwC-6cfwM:
undetectable		 3bjwC-6cfwM:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etx DNA HELICASE INO80

(Homo sapiens) 		no annotation 4 ILE G1088
SER G 829
PRO G 830
PHE G 831
 None
 0.83A 3bjwC-6etxG:
undetectable		 3bjwC-6etxG:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 VAL A 171
LEU A 170
LYS A  82
SER A  83
PRO A  84
 None
 1.23A 3bjwF-1aorA:
undetectable		 3bjwF-1aorA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 VAL A 169
LEU A 168
LYS A  81
SER A  82
PRO A  83
 None
 1.13A 3bjwF-1b25A:
0.0		 3bjwF-1b25A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		5 VAL A 243
LEU A 245
GLY A 185
SER A  14
THR A  16
 None
 1.28A 3bjwF-1escA:
undetectable		 3bjwF-1escA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 VAL A  53
GLY A  51
SER A 106
PRO A 382
THR A 210
 None
 1.26A 3bjwF-1ezvA:
undetectable		 3bjwF-1ezvA:
12.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		5 GLY A   6
LYS A  15
PRO A  17
PHE A  18
PRO A  19
 None
 0.53A 3bjwF-1gmzA:
19.5		 3bjwF-1gmzA:
57.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		5 ILE A   9
LYS A  15
PHE A  18
PRO A  19
THR A  23
 None
 1.26A 3bjwF-1gmzA:
19.5		 3bjwF-1gmzA:
57.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		5 VAL A 125
LEU A 128
GLY A 167
ILE A 168
SER A 147
 None
 1.17A 3bjwF-1gq7A:
0.0		 3bjwF-1gq7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A 227
ILE A 195
PRO A 223
PRO A 237
THR A 221
 None
 1.13A 3bjwF-1h3jA:
undetectable		 3bjwF-1h3jA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		5 VAL A 107
LEU A 104
GLY A 103
ILE A  99
THR A 517
 None
 1.13A 3bjwF-1iokA:
undetectable		 3bjwF-1iokA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		5 VAL A  59
GLY A 176
ILE A 186
PRO A  54
SER A  53
 None
 1.17A 3bjwF-1j3bA:
undetectable		 3bjwF-1j3bA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzq MAJOR SURFACE
ANTIGEN P30

(Toxoplasma
gondii) 		PF04092
(SAG) 		5 LEU A  32
GLY A 112
ILE A 114
SER A 121
THR A  18
 None
 1.19A 3bjwF-1kzqA:
undetectable		 3bjwF-1kzqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A  57
LEU A  56
GLY A 109
ILE A 132
LYS A  15
 None
 1.14A 3bjwF-1lxtA:
undetectable		 3bjwF-1lxtA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 492
GLY A 489
ILE A 450
PRO A 455
SER A 459
 3AG  A 900 (-4.9A)
None
None
None
None
 1.18A 3bjwF-1n21A:
undetectable		 3bjwF-1n21A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 VAL A  31
LEU A  30
GLY A 127
ILE A 175
LYS A  22
 None
 1.09A 3bjwF-1pujA:
undetectable		 3bjwF-1pujA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwg (2R)-PHOSPHO-3-SULFO
LACTATE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF02679
(ComA) 		5 LEU A  23
GLY A  22
ILE A  52
SER A  49
PRO A  73
 None
 1.24A 3bjwF-1qwgA:
undetectable		 3bjwF-1qwgA:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		5 LEU A   5
GLY A   6
LYS A  16
SER A  21
LYS A 115
 None
 0.90A 3bjwF-1s8hA:
20.4		 3bjwF-1s8hA:
62.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		5 VAL A 246
LEU A 247
ILE A 117
PRO A 101
PHE A  98
 None
 1.26A 3bjwF-1urhA:
undetectable		 3bjwF-1urhA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a00 POTASSIUM-TRANSPORTI
NG ATPASE B CHAIN

(Escherichia
coli) 		no annotation 5 VAL A 439
LEU A 440
GLY A 441
ILE A 323
PRO A 430
 None
 1.14A 3bjwF-2a00A:
undetectable		 3bjwF-2a00A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 VAL A  33
LEU A  34
GLY A  35
ILE A  40
THR A  44
 None
 1.23A 3bjwF-2ahwA:
undetectable		 3bjwF-2ahwA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 VAL A 466
GLY A 464
ILE A 513
LYS A 512
SER A 510
 None
 1.13A 3bjwF-2aw5A:
undetectable		 3bjwF-2aw5A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex3 DNA TERMINAL PROTEIN

(Bacillus virus
phi29) 		PF05435
(Phi-29_GP3) 		5 VAL B 105
LEU B 104
SER B 165
THR B  98
LYS B  90
 None
 1.21A 3bjwF-2ex3B:
undetectable		 3bjwF-2ex3B:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		5 LEU 1 603
GLY 1 599
ILE 1 510
LYS 1 509
SER 1 511
 None
 1.19A 3bjwF-2fji1:
undetectable		 3bjwF-2fji1:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 127
GLY A 193
ILE A 186
PHE A 191
PRO A 190
 None
 1.19A 3bjwF-2fpgA:
undetectable		 3bjwF-2fpgA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7u TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 VAL A  18
LEU A  19
GLY A  15
ILE A  12
THR A  51
 None
 1.10A 3bjwF-2g7uA:
undetectable		 3bjwF-2g7uA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i88 COLICIN-E1

(Escherichia
coli) 		PF01024
(Colicin) 		5 VAL A 479
LEU A 482
ILE A 451
PRO A 462
THR A 466
 None
 1.24A 3bjwF-2i88A:
undetectable		 3bjwF-2i88A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km1 PROTEIN DRE2

(Saccharomyces
cerevisiae) 		PF16803
(DRE2_N) 		5 VAL A  80
LEU A  81
LYS A  44
SER A  49
THR A  51
 None
 1.23A 3bjwF-2km1A:
undetectable		 3bjwF-2km1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld4 ANAMORSIN

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 LEU A  67
GLY A  66
ILE A  47
PRO A  98
LYS A 114
 None
 1.24A 3bjwF-2ld4A:
undetectable		 3bjwF-2ld4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5i BH3-INTERACTING
DOMAIN DEATH AGONIST

(Homo sapiens) 		PF06393
(BID) 		5 VAL A 106
LEU A 105
GLY A 104
SER A 100
SER A  96
 None
 1.22A 3bjwF-2m5iA:
undetectable		 3bjwF-2m5iA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 VAL A 172
GLY A 143
SER A 108
PHE A 105
PRO A 106
 None
 1.04A 3bjwF-2p4qA:
1.0		 3bjwF-2p4qA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 VAL A 230
LEU A 222
GLY A 223
ILE A 277
LYS A   1
 None
 1.11A 3bjwF-2qf7A:
undetectable		 3bjwF-2qf7A:
7.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		6 ILE A   9
LYS A  16
PRO A  18
PHE A  19
PRO A  20
SER A  21
 None
 1.46A 3bjwF-2qheA:
23.9		 3bjwF-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		8 VAL A   2
ILE A  10
LYS A  16
PRO A  18
PHE A  19
SER A  21
THR A  23
LYS A 115
 None
 0.74A 3bjwF-2qheA:
23.9		 3bjwF-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		10 VAL A   2
LEU A   5
GLY A   6
ILE A  10
LYS A  16
PRO A  18
PHE A  19
PRO A  20
SER A  21
THR A  23
 None
 0.58A 3bjwF-2qheA:
23.9		 3bjwF-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		9 VAL A   2
LEU A   5
GLY A   6
ILE A  10
LYS A  16
SER A  17
PRO A  18
PRO A  20
SER A  21
 None
 0.76A 3bjwF-2qheA:
23.9		 3bjwF-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		5 LEU A 300
GLY A 306
ILE A 285
PRO A 288
THR A 290
 None
 1.11A 3bjwF-2xciA:
undetectable		 3bjwF-2xciA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 VAL A  81
LEU A  80
GLY A  61
ILE A  59
LYS A  58
 None
 1.18A 3bjwF-2xsgA:
undetectable		 3bjwF-2xsgA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00731
(AIRC) 		5 VAL A 104
ILE A 122
PRO A  76
PHE A  55
THR A  73
 None
 1.26A 3bjwF-2ywxA:
undetectable		 3bjwF-2ywxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		5 VAL A 159
GLY A 191
ILE A 215
PRO A  52
SER A 247
 None
 1.25A 3bjwF-3bm3A:
undetectable		 3bjwF-3bm3A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		5 ILE A 518
SER A 373
SER A 376
THR A 417
LYS A  64
 None
 1.09A 3bjwF-3c2uA:
undetectable		 3bjwF-3c2uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 5 VAL A 237
LEU A  43
SER A  83
PHE A  72
THR A 216
 None
 1.14A 3bjwF-3cjiA:
undetectable		 3bjwF-3cjiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR

(Saccharomyces
cerevisiae) 		PF00996
(GDI) 		5 VAL G 266
LEU G 267
GLY G 277
LYS G   7
THR G 280
 None
 1.03A 3bjwF-3cpiG:
undetectable		 3bjwF-3cpiG:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		6 VAL A   2
GLY A   6
LYS A  15
PRO A  17
SER A  20
LYS A 105
 None
 0.67A 3bjwF-3dihA:
22.5		 3bjwF-3dihA:
64.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 VAL A 177
LEU A 178
GLY A 175
ILE A 171
THR A 146
 None
 1.14A 3bjwF-3fcaA:
undetectable		 3bjwF-3fcaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 258
LEU A 259
GLY A 256
ILE A 274
THR A 218
 None
 1.24A 3bjwF-3h2zA:
undetectable		 3bjwF-3h2zA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 VAL A 168
LEU A 171
GLY A 167
PRO A 108
THR A 103
 None
 1.14A 3bjwF-3ib3A:
undetectable		 3bjwF-3ib3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A1078
ILE A1095
SER A1094
PRO A1092
THR A1087
 None
 1.25A 3bjwF-3kuqA:
undetectable		 3bjwF-3kuqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 201
GLY A 240
ILE A 345
PRO A  14
PRO A  53
 None
 1.28A 3bjwF-3kzuA:
undetectable		 3bjwF-3kzuA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrv PRE-MRNA-SPLICING
FACTOR 19

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 337
GLY A 336
ILE A 289
SER A 334
PRO A 350
 None
 1.23A 3bjwF-3lrvA:
undetectable		 3bjwF-3lrvA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		5 VAL A 179
LEU A 180
ILE A 113
PHE A 172
THR A 161
 None
 1.28A 3bjwF-3ntxA:
undetectable		 3bjwF-3ntxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 VAL A 352
LEU A 351
GLY A 350
ILE A 348
PRO A 537
 None
 1.16A 3bjwF-3o8oA:
undetectable		 3bjwF-3o8oA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puo DIHYDRODIPICOLINATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		5 VAL A 183
LEU A 182
GLY A 159
ILE A 157
SER A 152
 None
 1.03A 3bjwF-3puoA:
undetectable		 3bjwF-3puoA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6o 2-HYDROXYHEPTA-2,4-D
IENE-1,
7-DIOATEISOMERASE

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase) 		5 GLY A  83
LYS A 113
SER A 114
PRO A 115
SER A 117
 None
 1.00A 3bjwF-3r6oA:
undetectable		 3bjwF-3r6oA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbt GLUTATHIONE
TRANSFERASE O1

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 LEU A 128
GLY A 126
ILE A 142
PHE A 137
THR A 133
 None
 1.18A 3bjwF-3rbtA:
undetectable		 3bjwF-3rbtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		5 VAL A 152
GLY A 150
ILE A 149
PRO A 188
SER A 212
 None
 1.27A 3bjwF-3s99A:
undetectable		 3bjwF-3s99A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		5 VAL A 606
LEU A 605
SER A 668
SER A 673
THR A 675
 None
 1.23A 3bjwF-3t0qA:
undetectable		 3bjwF-3t0qA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107

(Saccharomyces
cerevisiae) 		PF16770
(RTT107_BRCT_5)
PF16771
(RTT107_BRCT_6) 		5 VAL A 974
LEU A 975
GLY A 972
PRO A 965
LYS A1018
 None
 1.15A 3bjwF-3t7iA:
undetectable		 3bjwF-3t7iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF00106
(adh_short) 		5 VAL A 117
GLY A 113
ILE A 109
SER A 146
THR A 144
 None
 1.14A 3bjwF-3tl3A:
undetectable		 3bjwF-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul4 CELLULOSOME-ANCHORIN
G PROTEIN

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 VAL A  15
GLY A  13
ILE A  11
SER A  28
THR A 103
 None
 0.84A 3bjwF-3ul4A:
undetectable		 3bjwF-3ul4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		5 VAL A 246
LEU A 249
ILE A 177
PRO A 328
SER A 326
 None
 1.07A 3bjwF-3w53A:
undetectable		 3bjwF-3w53A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		5 VAL A  52
LEU A  27
GLY A  28
PRO A  34
THR A  37
 None
 1.03A 3bjwF-3wbxA:
undetectable		 3bjwF-3wbxA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.22A 3bjwF-3wv4A:
undetectable		 3bjwF-3wv4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.19A 3bjwF-3wvnA:
undetectable		 3bjwF-3wvnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 LEU A 263
GLY A 264
ILE A 276
LYS A 277
THR A  84
 None
 1.20A 3bjwF-3zfvA:
undetectable		 3bjwF-3zfvA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		5 VAL A1804
GLY A1808
ILE A1812
PRO B  59
THR B  63
 None
 0.87A 3bjwF-4by6A:
undetectable		 3bjwF-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 271
GLY A 273
PRO A 277
SER A 281
THR A 279
 None
9L9  A1300 (-3.4A)
9L9  A1300 (-4.1A)
None
9L9  A1300 ( 4.8A)
 1.28A 3bjwF-4cjxA:
0.8		 3bjwF-4cjxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		5 VAL B 167
LEU B 168
GLY B 169
ILE B 179
PRO B 183
 None
 1.24A 3bjwF-4di4B:
undetectable		 3bjwF-4di4B:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 VAL A 297
GLY A 299
SER A 345
THR A 329
LYS A 311
 None
 1.04A 3bjwF-4dshA:
undetectable		 3bjwF-4dshA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 VAL A 407
GLY A 410
SER A 303
PHE A 315
SER A 301
 None
 1.13A 3bjwF-4egtA:
undetectable		 3bjwF-4egtA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE

(Vibrio cholerae) 		no annotation 5 LEU A 134
ILE A 126
SER A 127
PHE A 123
THR A 110
 None
 1.27A 3bjwF-4evwA:
undetectable		 3bjwF-4evwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		5 VAL A 100
GLY A  98
ILE A 107
PRO A 106
THR B   6
 None
 1.17A 3bjwF-4f0uA:
undetectable		 3bjwF-4f0uA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 VAL B 970
LEU B 969
GLY B 985
ILE B 987
LYS B 592
 None
 1.23A 3bjwF-4f92B:
undetectable		 3bjwF-4f92B:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3

([Candida]
glabrata) 		PF00225
(Kinesin) 		6 VAL A 588
LEU A 587
ILE A 584
SER A 650
SER A 655
THR A 657
 None
 1.38A 3bjwF-4gkrA:
undetectable		 3bjwF-4gkrA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 LEU A 165
GLY A 166
ILE A  19
LYS A  32
PRO A  34
 None
 1.14A 3bjwF-4mo9A:
undetectable		 3bjwF-4mo9A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 GLY A 153
ILE A 135
PHE A 354
PRO A 355
THR A 358
 None
 1.20A 3bjwF-4nphA:
undetectable		 3bjwF-4nphA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		5 GLY A  35
ILE A  45
PRO A  68
PRO A  66
SER A  84
 None
None
None
PEG  A 402 (-4.1A)
PEG  A 402 (-3.5A)
 1.23A 3bjwF-4qrjA:
undetectable		 3bjwF-4qrjA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A 337
LEU A 336
GLY A 339
ILE A 343
SER A 344
 None
 1.27A 3bjwF-4wisA:
undetectable		 3bjwF-4wisA:
10.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		6 LEU A   5
GLY A   6
LYS A  15
PRO A  17
SER A  20
LYS A 105
 None
 0.76A 3bjwF-4wtbA:
21.5		 3bjwF-4wtbA:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		5 VAL B 359
GLY B 374
LYS B 379
SER B 380
THR B 337
 None
 1.24A 3bjwF-4xcgB:
undetectable		 3bjwF-4xcgB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 5 LEU D  80
GLY D  75
ILE D  73
PRO D  68
THR D   6
 None
 1.22A 3bjwF-4zg5D:
undetectable		 3bjwF-4zg5D:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 VAL A 512
LEU A 513
ILE A 485
LYS A 483
THR A 476
 None
 1.11A 3bjwF-5affA:
undetectable		 3bjwF-5affA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		5 VAL K 582
LEU K 583
GLY K 584
ILE K 585
PHE K 413
 None
 1.26A 3bjwF-5anbK:
undetectable		 3bjwF-5anbK:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 LEU E 205
GLY E 317
ILE E 318
PRO E 176
SER E 175
 None
 1.25A 3bjwF-5b04E:
undetectable		 3bjwF-5b04E:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2
CAPSID PROTEIN VP3

(Enterovirus D) 		PF00073
(Rhv) 		5 LEU B 217
GLY B 218
SER C 122
PHE B 117
THR B 115
 None
 0.93A 3bjwF-5bnnB:
undetectable		 3bjwF-5bnnB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 LEU A 543
ILE A 686
SER A 707
SER A 709
THR A 728
 None
 1.24A 3bjwF-5c9iA:
undetectable		 3bjwF-5c9iA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		5 GLY A  63
LYS A  59
PRO A  58
PHE A  56
SER A  85
 None
 1.25A 3bjwF-5cagA:
undetectable		 3bjwF-5cagA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		5 VAL A 107
LEU A 104
GLY A 103
ILE A  99
THR A 517
 None
 1.06A 3bjwF-5da8A:
undetectable		 3bjwF-5da8A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 150
GLY A 149
ILE A 176
PRO A 220
PRO A 216
 None
 1.25A 3bjwF-5gmsA:
undetectable		 3bjwF-5gmsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		5 VAL A  41
LEU A  40
GLY A  96
ILE A 136
LYS A  31
 None
 1.24A 3bjwF-5k8cA:
undetectable		 3bjwF-5k8cA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 VAL A 256
LEU A 257
GLY A 271
SER A 263
LYS A 345
 None
 1.14A 3bjwF-5lu4A:
undetectable		 3bjwF-5lu4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 VAL A1427
LEU A1368
GLY A1369
ILE A1343
PHE A1374
 None
EDO  A2014 (-4.2A)
None
None
GOL  A2046 ( 4.2A)
 1.02A 3bjwF-5mznA:
undetectable		 3bjwF-5mznA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 VAL A 294
LEU A 219
ILE A 222
SER A 197
LYS A 269
 None
None
None
NAP  A 502 (-3.1A)
NAP  A 502 (-2.9A)
 1.28A 3bjwF-5o8rA:
undetectable		 3bjwF-5o8rA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 LEU A 237
GLY A 236
PRO A  76
SER A  77
THR A  79
 None
 0.96A 3bjwF-5oreA:
undetectable		 3bjwF-5oreA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		5 PRO A  18
PHE A  19
PRO A  20
THR A  23
LYS A 115
 None
None
None
None
TRS  A 201 (-3.3A)
 0.71A 3bjwF-5tfvA:
20.8		 3bjwF-5tfvA:
59.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgm DIHYDROOROTASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		5 VAL A  21
LEU A  22
GLY A  19
PRO A  44
THR A  42
 None
None
None
None
ACT  A 403 (-4.4A)
 1.25A 3bjwF-5vgmA:
undetectable		 3bjwF-5vgmA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 VAL A 107
LEU A 104
GLY A 103
ILE A  99
THR A 516
 None
 1.09A 3bjwF-5w0sA:
undetectable		 3bjwF-5w0sA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		5 GLY A 265
ILE A 263
SER A  51
PRO A  52
THR A  55
 None
None
None
MES  A 303 ( 4.5A)
MES  A 303 (-4.6A)
 1.12A 3bjwF-5x6sA:
undetectable		 3bjwF-5x6sA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S15A

(Trichomonas
vaginalis) 		PF00410
(Ribosomal_S8) 		5 VAL W  73
GLY W 127
ILE W 125
LYS W 124
PRO W  77
 None
None
None
U  2 650 ( 3.3A)
G  2 911 ( 4.9A)
 1.09A 3bjwF-5xyiW:
undetectable		 3bjwF-5xyiW:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 5 LEU A   5
GLY A   6
LYS A  16
PRO A  18
SER A  21
 PE4  A 201 ( 4.7A)
PE4  A 201 (-3.3A)
None
PE4  A 201 (-4.6A)
None
 0.64A 3bjwF-6ce2A:
20.8		 3bjwF-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 VAL A 239
LEU A 240
GLY A 241
LYS A 244
THR A 259
 FAD  A 503 (-4.1A)
None
None
None
None
 1.23A 3bjwF-6cmzA:
undetectable		 3bjwF-6cmzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ILE A 937
PRO A 977
PHE A 978
THR A 537
LYS A 569
 None
 1.27A 3bjwF-6f9nA:
undetectable		 3bjwF-6f9nA:
22.22