SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_E_SVRE510

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
LYS A 105
TYR A 107
 None
 0.81A 3bjwA-1gmzA:
19.7		 3bjwA-1gmzA:
57.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
ASN A 114
TYR A 117
PRO A 121
 None
 0.97A 3bjwA-1godA:
19.9		 3bjwA-1godA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
TYR A 117
PRO A 121
PHE A 124
 None
 0.88A 3bjwA-1q6vA:
21.9		 3bjwA-1q6vA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
ASN A 114
LYS A 115
TYR A 117
 None
 0.83A 3bjwA-1s8hA:
20.4		 3bjwA-1s8hA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
LYS A 115
TYR A 117
PRO A 121
 None
 0.79A 3bjwA-1vipA:
21.0		 3bjwA-1vipA:
49.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
ASN A 114
TYR A 117
PRO A 121
 None
 1.28A 3bjwA-2qheA:
22.8		 3bjwA-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
LYS A 116
TYR A 117
PRO A 121
 None
 1.42A 3bjwA-2qheA:
22.8		 3bjwA-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
LYS A 105
TYR A 107
 None
 0.89A 3bjwA-3dihA:
22.1		 3bjwA-3dihA:
64.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
LYS A 105
TYR A 107
 None
None
None
None
SO4  A 203 (-4.4A)
 0.87A 3bjwA-4wtbA:
20.6		 3bjwA-4wtbA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
TYR A 107
PHE A 114
 None
None
None
SO4  A 203 (-4.4A)
None
 0.83A 3bjwA-4wtbA:
20.6		 3bjwA-4wtbA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 LYS A   7
GLY A  15
ARG A 107
LEU A 110
 None
 0.90A 3bjwE-1a2aA:
21.6		 3bjwE-1a2aA:
46.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgc GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Bos taurus) 		PF16647
(GCSF) 		4 GLN A 146
GLY A 150
ARG A 148
LEU A  36
 None
 0.88A 3bjwE-1bgcA:
undetectable		 3bjwE-1bgcA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bge GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Canis lupus) 		PF16647
(GCSF) 		4 GLN A 146
GLY A 150
ARG A 148
LEU A  36
 None
 1.06A 3bjwE-1bgeA:
undetectable		 3bjwE-1bgeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 VAL A 464
GLY A 496
ARG A 501
LEU A 502
 None
 1.06A 3bjwE-1c30A:
undetectable		 3bjwE-1c30A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A 168
GLN A 129
GLY A 108
LEU A  70
 None
 0.83A 3bjwE-1db3A:
undetectable		 3bjwE-1db3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 VAL A 381
GLY A 478
ARG A 483
LEU A  99
 None
 0.86A 3bjwE-1gl6A:
undetectable		 3bjwE-1gl6A:
14.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		4 LYS A   7
GLN A  11
GLY A  15
LEU A 110
 None
 0.96A 3bjwE-1godA:
20.1		 3bjwE-1godA:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 VAL A  65
GLN A 104
GLY A  76
ARG A 105
 None
 0.91A 3bjwE-1gr0A:
undetectable		 3bjwE-1gr0A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 VAL A 139
GLN A 456
GLY A 463
LEU A 510
 None
 1.01A 3bjwE-1gz7A:
undetectable		 3bjwE-1gz7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 VAL A  95
GLY A 406
ARG A 600
LEU A 385
 None
 1.09A 3bjwE-1i6qA:
undetectable		 3bjwE-1i6qA:
11.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 LYS A   7
GLY A  14
ARG A 107
LEU A 110
 None
 0.71A 3bjwE-1jiaA:
21.8		 3bjwE-1jiaA:
51.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		4 VAL A 120
GLN A  61
ARG A  59
LEU A   9
 None
 1.03A 3bjwE-1jikA:
undetectable		 3bjwE-1jikA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8j ENDOTHELIAL PROTEIN
C RECEPTOR

(Homo sapiens) 		PF16497
(MHC_I_3) 		4 VAL A  40
GLN A  66
GLY A  68
ARG A  64
 None
None
PTY  A 200 (-4.2A)
None
 1.06A 3bjwE-1l8jA:
undetectable		 3bjwE-1l8jA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 GLN A1011
GLY A1014
ARG A1107
LEU A1110
 None
 0.27A 3bjwE-1mc2A:
21.0		 3bjwE-1mc2A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI

(Pseudomonas
aeruginosa) 		PF00765
(Autoind_synth) 		4 VAL A 146
LYS A 150
GLY A 156
LEU A 188
 None
SO4  A 402 (-4.7A)
None
None
 1.07A 3bjwE-1ro5A:
undetectable		 3bjwE-1ro5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
INHIBIN BETA A CHAIN

(Homo sapiens;
Mus musculus) 		PF00019
(TGF_beta)
PF01064
(Activin_recp) 		4 GLN A  31
GLY A  29
ARG B  87
LEU A  57
 None
 1.10A 3bjwE-1s4yA:
undetectable		 3bjwE-1s4yA:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		4 GLN A  11
GLY A  14
ARG A 107
LEU A 110
 None
 0.47A 3bjwE-1s8hA:
20.5		 3bjwE-1s8hA:
62.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  36
GLN A  53
GLY A  15
LEU A 112
 None
 0.98A 3bjwE-1uqxA:
undetectable		 3bjwE-1uqxA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		4 VAL A 403
GLY A  74
ARG A   9
LEU A 142
 None
 0.99A 3bjwE-1uwiA:
undetectable		 3bjwE-1uwiA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		4 VAL A  60
GLN A 225
GLY A 269
LEU A 261
 None
 1.06A 3bjwE-1vkyA:
undetectable		 3bjwE-1vkyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 VAL B 168
GLY B 198
ARG B 208
LEU B 242
 None
 1.05A 3bjwE-1wa5B:
undetectable		 3bjwE-1wa5B:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 500
GLN A  81
GLY A 482
ARG A 444
 None
 1.05A 3bjwE-1xkwA:
undetectable		 3bjwE-1xkwA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdv PHAGE-RELATED
CONSERVED
HYPOTHETICAL
PROTEIN, BB2244

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		4 VAL A  15
GLY A 131
ARG A  94
LEU A 191
 None
 1.05A 3bjwE-2bdvA:
undetectable		 3bjwE-2bdvA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 943
GLN A1165
GLY A1129
ARG A1127
 None
None
None
EDO  A2187 (-4.7A)
 0.93A 3bjwE-2bzlA:
undetectable		 3bjwE-2bzlA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		4 VAL A  67
LYS A  71
GLY A  77
ARG A 328
 None
 0.82A 3bjwE-2c1hA:
undetectable		 3bjwE-2c1hA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		4 VAL A  78
GLN A  21
GLY A  87
ARG A  36
 None
DUN  A1266 (-3.6A)
None
None
 1.01A 3bjwE-2cjeA:
undetectable		 3bjwE-2cjeA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 VAL A 184
GLN A 194
GLY A 192
ARG B  54
 None
 1.01A 3bjwE-2d0vA:
undetectable		 3bjwE-2d0vA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft0 TDP-FUCOSAMINE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 4 LYS A 206
GLN A 210
GLY A 212
LEU A 182
 None
 0.95A 3bjwE-2ft0A:
undetectable		 3bjwE-2ft0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		4 VAL A  79
GLY A  61
ARG A  20
LEU A  21
 None
LLP  A  58 ( 4.2A)
None
None
 1.05A 3bjwE-2gn1A:
undetectable		 3bjwE-2gn1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7s AMPHINASE-2

(Rana pipiens) 		PF00074
(RnaseA) 		4 VAL A  66
LYS A  68
GLY A 112
LEU A  76
 None
 0.89A 3bjwE-2p7sA:
undetectable		 3bjwE-2p7sA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		5 LYS A   7
GLN A  11
GLY A  15
ARG A 107
LEU A 110
 None
 1.29A 3bjwE-2ph4A:
19.1		 3bjwE-2ph4A:
57.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
GLY A  14
ARG A 107
LEU A 110
 None
 0.97A 3bjwE-2qheA:
23.7		 3bjwE-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 VAL A   3
GLN A  11
GLY A  14
ARG A 107
LEU A 110
 None
 0.45A 3bjwE-2qheA:
23.7		 3bjwE-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 LYS A 385
GLY A 359
ARG A 633
LEU A 629
 None
 1.01A 3bjwE-2vmfA:
undetectable		 3bjwE-2vmfA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		4 VAL A  30
GLY A  59
ARG A  57
LEU A 149
 None
None
OTP  A1174 (-3.9A)
OTP  A1174 ( 4.3A)
 0.98A 3bjwE-2x32A:
undetectable		 3bjwE-2x32A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		4 LYS A 352
GLN A 355
GLY A 481
LEU A 177
 None
 1.03A 3bjwE-2yu1A:
undetectable		 3bjwE-2yu1A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 LYS A 392
GLN A 396
GLY A 399
LEU A 545
 None
 0.90A 3bjwE-3a5iA:
undetectable		 3bjwE-3a5iA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 VAL A 247
GLY A 312
ARG A 310
LEU A 404
 None
 1.10A 3bjwE-3cf4A:
undetectable		 3bjwE-3cf4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 VAL A  55
GLN A  22
GLY A 570
ARG A  21
 None
 1.04A 3bjwE-3cmmA:
undetectable		 3bjwE-3cmmA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04099
(Sybindin) 		4 VAL B 265
GLN B 257
GLY B 224
LEU A 206
 None
 1.02A 3bjwE-3cueB:
undetectable		 3bjwE-3cueB:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LYS A 130
GLN A 133
GLY A 135
LEU A 150
 None
 1.11A 3bjwE-3ecqA:
undetectable		 3bjwE-3ecqA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737

(Streptococcus
mutans) 		PF12146
(Hydrolase_4) 		4 VAL A 296
LYS A 300
GLN A 304
GLY A 306
 None
 0.77A 3bjwE-3fnbA:
undetectable		 3bjwE-3fnbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imk PUTATIVE MOLYBDENUM
CARRIER PROTEIN

(Syntrophus
aciditrophicus) 		PF12694
(MoCo_carrier) 		4 VAL A  37
GLN A  15
GLY A 135
LEU A  84
 None
None
GOL  A 158 (-4.1A)
None
 0.89A 3bjwE-3imkA:
undetectable		 3bjwE-3imkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		4 VAL A 352
GLN A 305
GLY A 310
LEU A 186
 None
 1.11A 3bjwE-3ivrA:
undetectable		 3bjwE-3ivrA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A  69
GLY A  14
ARG A 117
LEU A  30
 None
 1.09A 3bjwE-3kkjA:
undetectable		 3bjwE-3kkjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 VAL A 171
GLY A  75
ARG A  71
LEU A  59
 None
 1.11A 3bjwE-3kkyA:
undetectable		 3bjwE-3kkyA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 VAL A 372
GLN A  84
GLY A  65
LEU A 385
 None
 1.10A 3bjwE-3l4dA:
undetectable		 3bjwE-3l4dA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		4 VAL A   5
LYS A   2
GLY A 313
LEU A 381
 None
 1.11A 3bjwE-3mktA:
undetectable		 3bjwE-3mktA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml4 PROTEIN DOK-7

(Mus musculus) 		PF02174
(IRS) 		4 VAL A 111
GLY A 150
ARG A 142
LEU A 124
 None
 1.10A 3bjwE-3ml4A:
undetectable		 3bjwE-3ml4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obw PROTEIN PELOTA
HOMOLOG

(Sulfolobus
solfataricus) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 VAL A  13
GLY A 226
ARG A 224
LEU A 139
 None
 1.02A 3bjwE-3obwA:
undetectable		 3bjwE-3obwA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6l SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 VAL A 266
LYS A 270
GLN A 274
LEU A 242
 None
 1.09A 3bjwE-3p6lA:
undetectable		 3bjwE-3p6lA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 VAL B 158
GLY B 225
ARG B  33
LEU B 221
 None
 1.02A 3bjwE-3pdiB:
undetectable		 3bjwE-3pdiB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 VAL B 565
GLN B 560
GLY B 575
LEU B 611
 None
 0.98A 3bjwE-3s4wB:
undetectable		 3bjwE-3s4wB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 VAL A  16
GLN A 229
GLY A 267
ARG A 265
 None
 0.82A 3bjwE-3ssmA:
undetectable		 3bjwE-3ssmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		4 VAL A 214
GLY A  63
ARG A  65
LEU A 118
 None
 1.07A 3bjwE-3t7bA:
undetectable		 3bjwE-3t7bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN 98

(Mus musculus) 		PF04096
(Nucleoporin2) 		4 LYS C 876
GLN C 862
GLY C 860
ARG C 857
 None
 1.03A 3bjwE-3tknC:
undetectable		 3bjwE-3tknC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		4 LYS A 252
GLN A 248
GLY A 261
ARG A 259
 None
 1.07A 3bjwE-3zfcA:
undetectable		 3bjwE-3zfcA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  65
GLY A 165
ARG A 162
LEU A  93
 None
 1.04A 3bjwE-4a0sA:
undetectable		 3bjwE-4a0sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 VAL A 233
GLN A 241
GLY A 283
LEU A 163
 None
 1.01A 3bjwE-4ayxA:
undetectable		 3bjwE-4ayxA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 VAL A  99
GLY A 191
ARG A 189
LEU A 313
 None
 1.07A 3bjwE-4b45A:
undetectable		 3bjwE-4b45A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 4 LYS A 531
GLN A 524
GLY A 528
LEU A 579
 None
 1.09A 3bjwE-4bb9A:
undetectable		 3bjwE-4bb9A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 VAL A 240
GLN A 207
GLY A 211
LEU A 217
 None
 1.05A 3bjwE-4byfA:
undetectable		 3bjwE-4byfA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cf3 L-HALOACID
DEHALOGENASE

(Rhodobacteraceae) 		PF00702
(Hydrolase) 		4 VAL A 162
GLY A 198
ARG A 196
LEU A 230
 None
 0.98A 3bjwE-4cf3A:
undetectable		 3bjwE-4cf3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		4 VAL A 107
GLN A  65
GLY A  92
LEU A 190
 None
NAP  A 301 ( 4.5A)
NAP  A 301 ( 3.7A)
NAP  A 301 (-3.7A)
 0.97A 3bjwE-4gvxA:
undetectable		 3bjwE-4gvxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ize INTERLEUKIN-36 GAMMA

(Homo sapiens) 		PF00340
(IL1) 		4 LYS A 103
GLN A 102
GLY A  78
LEU A  42
 None
 1.04A 3bjwE-4izeA:
undetectable		 3bjwE-4izeA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiv BILE ACID RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 VAL A 303
LYS A 307
GLN A 313
LEU A 256
 None
 1.03A 3bjwE-4oivA:
undetectable		 3bjwE-4oivA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 VAL A  75
GLY A 783
ARG A 781
LEU A 960
 None
 1.07A 3bjwE-4q0wA:
undetectable		 3bjwE-4q0wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 VAL A  93
GLY A 227
ARG A 213
LEU A  66
 None
PMP  A 402 ( 4.6A)
None
None
 0.94A 3bjwE-4r5zA:
undetectable		 3bjwE-4r5zA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 GLN A1311
GLY A1257
ARG A1255
LEU A1191
 None
 1.06A 3bjwE-4u48A:
undetectable		 3bjwE-4u48A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  85
GLN A 110
GLY A 105
LEU A 330
 None
 1.00A 3bjwE-4uuoA:
undetectable		 3bjwE-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		4 VAL A 102
GLY A 236
ARG A 222
LEU A  77
 None
None
PEG  A 404 (-3.2A)
None
 0.93A 3bjwE-4wbtA:
undetectable		 3bjwE-4wbtA:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LYS A   7
GLN A  11
GLY A  14
ARG A  97
LEU A 100
 None
 0.92A 3bjwE-4wtbA:
21.2		 3bjwE-4wtbA:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 VAL A 140
GLN A 150
GLY A 112
LEU A  48
 None
None
GOL  A 917 ( 3.9A)
None
 0.97A 3bjwE-4xriA:
undetectable		 3bjwE-4xriA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0w YEAZ

(Pseudomonas
aeruginosa) 		PF00814
(Peptidase_M22) 		4 VAL A 151
GLN A 129
ARG A 136
LEU A 194
 None
 1.05A 3bjwE-4y0wA:
undetectable		 3bjwE-4y0wA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 VAL A 226
GLN A 319
GLY A 322
LEU A 177
 None
 1.07A 3bjwE-4y9lA:
undetectable		 3bjwE-4y9lA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Grosmannia
penicillata) 		PF00961
(LAGLIDADG_1) 		4 VAL A  65
GLN A  43
GLY A  20
LEU A  96
 None
 1.08A 3bjwE-4yhxA:
undetectable		 3bjwE-4yhxA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A 594
GLY A 392
ARG A 362
LEU A 363
 MCN  A 801 (-4.4A)
None
None
None
 1.10A 3bjwE-4zohA:
undetectable		 3bjwE-4zohA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 GLN A1319
GLY A1265
ARG A1263
LEU A1199
 None
 1.03A 3bjwE-5a42A:
undetectable		 3bjwE-5a42A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0v MATRIX PROTEIN VP40

(Marburg
marburgvirus) 		PF07447
(VP40) 		4 VAL A 303
GLN A 143
ARG A 125
LEU A 126
 None
 1.00A 3bjwE-5b0vA:
undetectable		 3bjwE-5b0vA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		4 VAL A 140
GLN A 175
GLY A 177
ARG A 173
 None
 0.87A 3bjwE-5fclA:
undetectable		 3bjwE-5fclA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw9 GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Homo sapiens) 		PF16647
(GCSF) 		4 GLN A 146
GLY A 150
ARG A 148
LEU A  36
 None
 1.06A 3bjwE-5gw9A:
undetectable		 3bjwE-5gw9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		4 VAL A 268
GLN A 418
GLY A 416
LEU A 156
 None
 0.87A 3bjwE-5l35A:
undetectable		 3bjwE-5l35A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		4 VAL A 121
LYS A 125
GLN A 129
GLY A 131
 None
 1.01A 3bjwE-5lirA:
undetectable		 3bjwE-5lirA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		4 VAL A 183
GLY A  32
ARG A  37
LEU A  63
 None
 1.07A 3bjwE-5n2iA:
undetectable		 3bjwE-5n2iA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 VAL A 229
GLY A 135
ARG A 170
LEU A 390
 None
 1.10A 3bjwE-5o1mA:
undetectable		 3bjwE-5o1mA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 VAL A 161
LYS A 165
GLY A 171
LEU A  86
 None
 0.94A 3bjwE-5ocsA:
undetectable		 3bjwE-5ocsA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		4 VAL A 214
GLN A 179
GLY A 184
ARG A 181
 None
 1.06A 3bjwE-5uc7A:
undetectable		 3bjwE-5uc7A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 4 VAL D 283
GLN D 289
GLY D 293
LEU D 251
 None
 1.04A 3bjwE-5ui3D:
undetectable		 3bjwE-5ui3D:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 4 GLN A 275
GLY A 280
ARG A 277
LEU A 257
 None
 1.04A 3bjwE-5vfzA:
undetectable		 3bjwE-5vfzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 4 VAL A  50
LYS A  54
GLN A  58
GLY A  60
 None
 0.85A 3bjwE-5w3wA:
undetectable		 3bjwE-5w3wA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 4 VAL A 100
GLY A 120
ARG A 118
LEU A 197
 None
 1.07A 3bjwE-5wm4A:
undetectable		 3bjwE-5wm4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 4 VAL A   3
GLY A  14
ARG A  98
LEU A 101
 None
None
None
TRS  A 211 (-4.0A)
 0.54A 3bjwE-5wzmA:
20.0		 3bjwE-5wzmA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs9 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		no annotation 4 VAL A 107
GLN A 114
GLY A 116
LEU A 185
 None
 1.11A 3bjwE-5xs9A:
undetectable		 3bjwE-5xs9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 4 VAL A 106
LYS A 103
GLN A 100
GLY A  97
 None
 1.06A 3bjwE-5y50A:
undetectable		 3bjwE-5y50A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 4 LYS A 105
GLY A 112
ARG A 118
LEU A  85
 NDP  A 502 ( 4.4A)
None
None
None
 1.11A 3bjwE-5yvsA:
undetectable		 3bjwE-5yvsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A 209
GLN A 151
GLY A 147
LEU A  34
 None
 1.10A 3bjwE-5z9aA:
undetectable		 3bjwE-5z9aA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 VAL A 421
GLN A 186
GLY A 191
LEU A 254
 None
 1.06A 3bjwE-6a8mA:
undetectable		 3bjwE-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n PGV19 FAB HEAVY
CHAIN
PGV19 LIGHT CHAIN

(Homo sapiens) 		no annotation 4 VAL E  39
GLN D  39
GLY E 100
LEU E   4
 None
 0.98A 3bjwE-6b0nE:
undetectable		 3bjwE-6b0nE:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 4 VAL A   3
GLN A  11
GLY A  15
ARG A 107
 None
 0.55A 3bjwE-6ce2A:
20.7		 3bjwE-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 4 LYS A 392
GLN A 396
GLY A 399
LEU A 545
 None
 1.02A 3bjwE-6ch3A:
undetectable		 3bjwE-6ch3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A   7
VAL A  30
THR A 306
THR A   9
 None
 1.26A 3bjwG-1e0tA:
0.0		 3bjwG-1e0tA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fux HYPOTHETICAL 19.5
KDA PROTEIN IN
EMRE-RUS INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 VAL A  67
VAL A  93
THR A 127
THR A  65
 None
 1.07A 3bjwG-1fuxA:
0.0		 3bjwG-1fuxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 905
THR A 975
THR A 954
ARG A 906
 None
None
2MD  A1001 ( 4.4A)
None
 1.23A 3bjwG-1h0hA:
0.0		 3bjwG-1h0hA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 257
VAL A 190
THR A 271
THR A 183
 None
 1.28A 3bjwG-1h2bA:
0.0		 3bjwG-1h2bA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		4 VAL A 187
VAL A 186
THR A 256
THR A 189
 None
 1.26A 3bjwG-1i2lA:
0.0		 3bjwG-1i2lA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 VAL A 442
THR A  44
THR A 176
ARG A 439
 None
 0.86A 3bjwG-1lqtA:
0.0		 3bjwG-1lqtA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 198
VAL A 197
THR A  85
THR A 180
 None
None
None
PLP  A 400 ( 4.1A)
 1.10A 3bjwG-1n8pA:
0.0		 3bjwG-1n8pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyo IMMUNOGENIC PROTEIN
MPT70

(Mycobacterium
tuberculosis) 		PF02469
(Fasciclin) 		4 VAL A 102
VAL A 103
THR A 147
THR A  99
 None
 1.25A 3bjwG-1nyoA:
undetectable		 3bjwG-1nyoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 VAL A 112
THR A 137
THR A  85
ARG A 209
 None
 1.28A 3bjwG-1v84A:
0.0		 3bjwG-1v84A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A  86
VAL A  87
THR A 168
THR A  76
 None
 1.12A 3bjwG-1wqlA:
undetectable		 3bjwG-1wqlA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 203
VAL A 204
THR A 129
THR A 217
 None
 1.07A 3bjwG-1y9gA:
undetectable		 3bjwG-1y9gA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii) 		PF00235
(Profilin) 		4 VAL A 112
VAL A 113
THR A   8
THR A 108
 None
 1.27A 3bjwG-2acgA:
undetectable		 3bjwG-2acgA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 4 VAL P 270
THR P 321
THR P 283
ARG P 286
 None
 1.17A 3bjwG-2btvP:
undetectable		 3bjwG-2btvP:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 VAL A 141
VAL A 142
THR A 250
THR A 137
 MAN  A 751 ( 4.1A)
None
MAN  A 750 (-2.0A)
None
 0.98A 3bjwG-2ciyA:
undetectable		 3bjwG-2ciyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 VAL A 192
VAL A 193
THR A 167
THR A 212
 None
 1.27A 3bjwG-2ddwA:
undetectable		 3bjwG-2ddwA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 VAL A 106
VAL A  12
THR A 275
THR A 104
 None
 1.13A 3bjwG-2gqwA:
undetectable		 3bjwG-2gqwA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A 253
VAL A 254
THR A 307
THR A 249
 None
 1.27A 3bjwG-2hunA:
undetectable		 3bjwG-2hunA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		4 VAL A 207
VAL A 139
THR A 214
THR A 205
 None
 1.24A 3bjwG-2j4rA:
undetectable		 3bjwG-2j4rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		4 VAL A2785
VAL A2798
THR A2730
THR A2787
 None
 1.25A 3bjwG-2jd4A:
undetectable		 3bjwG-2jd4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 693
VAL A 694
THR A 417
THR A 689
 None
 1.10A 3bjwG-2nq5A:
1.2		 3bjwG-2nq5A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 VAL A 137
VAL A 134
THR A 118
THR A 132
 None
 1.10A 3bjwG-2pi5A:
undetectable		 3bjwG-2pi5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 VAL A  97
VAL A  98
THR A 254
THR A  95
 None
 1.09A 3bjwG-2q6uA:
undetectable		 3bjwG-2q6uA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
THR A  23
THR A  70
ARG A  72
 None
 1.17A 3bjwG-2qheA:
22.6		 3bjwG-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
VAL A   3
THR A  23
THR A  70
 None
 0.79A 3bjwG-2qheA:
22.6		 3bjwG-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 336
VAL A 327
THR A 265
THR A 334
 None
None
ADE  A 488 (-4.3A)
None
 1.27A 3bjwG-2qluA:
undetectable		 3bjwG-2qluA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr3 TWO-COMPONENT SYSTEM
RESPONSE REGULATOR

(Bacteroides
fragilis) 		PF00072
(Response_reg) 		4 VAL A  48
VAL A  49
THR A 117
THR A   3
 None
 1.20A 3bjwG-2qr3A:
undetectable		 3bjwG-2qr3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL S  65
VAL S  32
THR S  79
THR S  64
 None
 1.12A 3bjwG-2wpmS:
undetectable		 3bjwG-2wpmS:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 VAL A  31
VAL A  32
THR A 121
ARG A  30
 None
 1.22A 3bjwG-2x3nA:
1.3		 3bjwG-2x3nA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		4 VAL A 522
VAL A 436
THR A 359
THR A 520
 None
 1.24A 3bjwG-2xrcA:
undetectable		 3bjwG-2xrcA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A  62
VAL A  61
THR A  89
THR A  36
 None
 1.25A 3bjwG-2yq4A:
undetectable		 3bjwG-2yq4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbc 83AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR ASNC

(Sulfurisphaera
tokodaii) 		PF01037
(AsnC_trans_reg) 		4 VAL A  42
VAL A  31
THR A  69
THR A  29
 None
None
ILE  A  84 (-3.6A)
None
 1.19A 3bjwG-2zbcA:
undetectable		 3bjwG-2zbcA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 VAL A 125
VAL A 124
THR A  83
THR A 100
 None
 1.27A 3bjwG-3a1iA:
undetectable		 3bjwG-3a1iA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 VAL A 237
VAL A 268
THR A 242
THR A 235
 None
 1.26A 3bjwG-3b90A:
undetectable		 3bjwG-3b90A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		4 VAL A 118
VAL A 117
THR A  99
THR A  34
 None
 0.86A 3bjwG-3dtoA:
undetectable		 3bjwG-3dtoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A  81
VAL A  82
THR A 156
THR A  71
 None
 1.09A 3bjwG-3eqqA:
undetectable		 3bjwG-3eqqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 VAL A 489
VAL A 490
THR A 439
THR A 396
 None
 1.04A 3bjwG-3gecA:
undetectable		 3bjwG-3gecA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA'

(Escherichia
coli) 		PF09115
(DNApol3-delta_C)
PF13177
(DNA_pol3_delta2) 		4 VAL E 112
VAL E 111
THR E 131
THR E  78
 None
 1.19A 3bjwG-3glgE:
undetectable		 3bjwG-3glgE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 VAL A 737
VAL A 736
THR A 802
THR A 712
 None
 1.27A 3bjwG-3h09A:
undetectable		 3bjwG-3h09A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm4 CHEMOTAXIS PROTEIN
CHEX

(Desulfovibrio
alaskensis) 		PF13690
(CheX) 		4 VAL A  49
VAL A  48
THR A  16
THR A 117
 UNL  A 156 (-4.2A)
UNL  A 156 (-4.0A)
None
None
 1.24A 3bjwG-3hm4A:
undetectable		 3bjwG-3hm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A 204
VAL A 192
THR A 234
THR A 202
 None
 1.11A 3bjwG-3hrdA:
undetectable		 3bjwG-3hrdA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 VAL A 234
VAL A 233
THR A 213
THR A 238
 None
 1.25A 3bjwG-3ihaA:
undetectable		 3bjwG-3ihaA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j23 CAPSID PROTEIN VP1

(Enterovirus A) 		PF00073
(Rhv) 		4 VAL A 249
VAL A 248
THR A 237
ARG A 250
 None
 1.16A 3bjwG-3j23A:
undetectable		 3bjwG-3j23A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		4 VAL A 110
VAL A  85
THR A 221
THR A 108
 None
AHZ  A 500 (-4.8A)
None
None
 1.27A 3bjwG-3jskA:
0.7		 3bjwG-3jskA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 VAL A 434
VAL A 428
THR A 389
THR A 436
 None
 1.21A 3bjwG-3kyaA:
undetectable		 3bjwG-3kyaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 594
VAL A 595
THR A 537
THR A 509
 None
 1.21A 3bjwG-3ldrA:
undetectable		 3bjwG-3ldrA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 VAL A 136
VAL A 124
THR A 152
THR A 138
 None
 1.27A 3bjwG-3lmlA:
undetectable		 3bjwG-3lmlA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		4 VAL A 280
VAL A 281
THR A 288
THR A 276
 None
 0.93A 3bjwG-3m66A:
undetectable		 3bjwG-3m66A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbe MHC CLASS II H2-IAG7
BETA CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 VAL B  88
THR B  21
THR B  90
ARG B  93
 None
 1.18A 3bjwG-3mbeB:
undetectable		 3bjwG-3mbeB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 VAL A 232
VAL A 245
THR A  62
THR A 234
 None
 1.25A 3bjwG-3mfdA:
undetectable		 3bjwG-3mfdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 VAL A 198
VAL A 199
THR A 135
THR A 154
 None
 1.24A 3bjwG-3ngxA:
undetectable		 3bjwG-3ngxA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 VAL A  17
VAL A  18
THR A 233
THR A  40
 None
 1.13A 3bjwG-3rd5A:
undetectable		 3bjwG-3rd5A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 VAL A 378
VAL A 350
THR A 401
THR A 380
 None
 1.03A 3bjwG-3riqA:
undetectable		 3bjwG-3riqA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		4 VAL A 126
VAL A 179
THR A 143
THR A 128
 None
 1.15A 3bjwG-3rq1A:
undetectable		 3bjwG-3rq1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rty PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 VAL A 489
VAL A 490
THR A 439
THR A 396
 None
 0.94A 3bjwG-3rtyA:
undetectable		 3bjwG-3rtyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 VAL A 159
THR A  74
THR A 142
ARG A 161
 None
 1.26A 3bjwG-3t3oA:
undetectable		 3bjwG-3t3oA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 VAL A 159
VAL A 158
THR A 389
THR A 142
 None
 1.25A 3bjwG-3t3oA:
undetectable		 3bjwG-3t3oA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ug7 ARSENICAL
PUMP-DRIVING ATPASE

(Methanocaldococcus
jannaschii) 		PF02374
(ArsA_ATPase) 		4 VAL A  91
VAL A  58
THR A  40
THR A  81
 None
None
MG  A 403 ( 3.2A)
None
 1.18A 3bjwG-3ug7A:
undetectable		 3bjwG-3ug7A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 VAL A 227
VAL A 250
THR A 277
THR A 196
 None
 1.27A 3bjwG-3zpcA:
undetectable		 3bjwG-3zpcA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 VAL A 469
VAL A 468
THR A 474
THR A 465
 None
 1.21A 3bjwG-4ah6A:
undetectable		 3bjwG-4ah6A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 VAL A 335
VAL A 357
THR A 388
THR A 337
 None
 1.12A 3bjwG-4bjuA:
2.4		 3bjwG-4bjuA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL A 252
VAL A 253
THR A 554
THR A 248
 None
 1.05A 3bjwG-4cgyA:
1.0		 3bjwG-4cgyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		4 VAL A  53
VAL A  40
THR A  99
THR A  38
 None
 1.09A 3bjwG-4cp6A:
undetectable		 3bjwG-4cp6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		4 VAL A 222
VAL A 249
THR A 201
THR A 220
 None
 1.28A 3bjwG-4dn7A:
undetectable		 3bjwG-4dn7A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 VAL A 205
VAL A 206
THR A 188
THR A 201
 None
 0.96A 3bjwG-4f0sA:
undetectable		 3bjwG-4f0sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 VAL A 114
VAL A 111
THR A 146
THR A  74
 None
 1.25A 3bjwG-4g2rA:
undetectable		 3bjwG-4g2rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 181
VAL H 182
THR L 114
THR H 165
 None
 1.24A 3bjwG-4idjH:
undetectable		 3bjwG-4idjH:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.22A 3bjwG-4iyoB:
undetectable		 3bjwG-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js7 CELLULOSE BINDING
PROTEIN

(Clavibacter
michiganensis) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		4 VAL A 179
VAL A 180
THR A 109
THR A 172
 None
 1.27A 3bjwG-4js7A:
undetectable		 3bjwG-4js7A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio cholerae) 		PF01135
(PCMT) 		4 VAL A  79
VAL A 100
THR A 148
THR A  77
 None
None
SAH  A 301 (-3.4A)
None
 1.12A 3bjwG-4l7vA:
undetectable		 3bjwG-4l7vA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		4 VAL X 172
VAL X 173
THR X 157
THR X 198
 None
 1.16A 3bjwG-4li3X:
undetectable		 3bjwG-4li3X:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		4 VAL A  41
VAL A  29
THR A 127
THR A  43
 None
 1.27A 3bjwG-4lq0A:
undetectable		 3bjwG-4lq0A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 310
VAL A 311
THR A 356
THR A 306
 None
None
None
HEM  A 600 ( 3.2A)
 1.08A 3bjwG-4nkyA:
undetectable		 3bjwG-4nkyA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		4 VAL A  51
VAL A  52
THR A 130
THR A  47
 None
 0.97A 3bjwG-4qdkA:
undetectable		 3bjwG-4qdkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 VAL A 122
VAL A 166
THR A  81
THR A 124
 None
 1.00A 3bjwG-4r27A:
undetectable		 3bjwG-4r27A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 VAL A  67
VAL A  68
THR A 126
THR A  63
 None
 0.99A 3bjwG-4u16A:
undetectable		 3bjwG-4u16A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 VAL C 182
VAL C 183
THR C 158
THR C 178
 None
 1.27A 3bjwG-4u1dC:
undetectable		 3bjwG-4u1dC:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 VAL A 239
THR A 163
THR A 236
ARG A 231
 None
 1.21A 3bjwG-4u3aA:
undetectable		 3bjwG-4u3aA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 VAL A 639
VAL A 640
THR A 541
THR A 634
 None
 1.26A 3bjwG-4u90A:
undetectable		 3bjwG-4u90A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri) 		no annotation 4 VAL a 182
VAL a 183
THR a 158
THR a 178
 None
 1.23A 3bjwG-4uera:
undetectable		 3bjwG-4uera:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvw CAPSID PROTEIN VP1

(Enterovirus A) 		no annotation 4 VAL E 249
VAL E 248
THR E 237
ARG E 250
 None
 1.18A 3bjwG-4yvwE:
undetectable		 3bjwG-4yvwE:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 VAL B 201
VAL B 200
THR B 411
THR B 208
 None
 1.09A 3bjwG-5a8rB:
undetectable		 3bjwG-5a8rB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq3 RHAMNOSE ABC
TRANSPORTER,
RHAMNOSE-BINDING
PROTEIN

(Actinomyces
odontolyticus) 		PF13407
(Peripla_BP_4) 		4 VAL A 334
VAL A 335
THR A 135
THR A 327
 None
 1.18A 3bjwG-5bq3A:
undetectable		 3bjwG-5bq3A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 VAL A 175
VAL A 176
THR A 325
THR A 173
 None
 1.25A 3bjwG-5cdiA:
undetectable		 3bjwG-5cdiA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L1

(Deinococcus
radiodurans) 		PF00687
(Ribosomal_L1) 		4 VAL 0 166
VAL 0 167
THR 0 211
THR 0 164
 C  X2178 ( 4.3A)
None
A  X2176 ( 3.8A)
C  X2179 ( 3.3A)
 1.25A 3bjwG-5dm60:
undetectable		 3bjwG-5dm60:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 VAL A 377
VAL A 378
THR A 363
THR A 373
 None
None
None
ADP  A 501 (-3.8A)
 1.17A 3bjwG-5dmhA:
undetectable		 3bjwG-5dmhA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		4 VAL A 167
VAL A 168
THR A 155
THR A  72
 None
 1.12A 3bjwG-5eogA:
undetectable		 3bjwG-5eogA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 VAL B 199
VAL B 198
THR B 283
ARG B 184
 None
 1.22A 3bjwG-5gq0B:
undetectable		 3bjwG-5gq0B:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		4 VAL A 206
VAL A 182
THR A 212
THR A 204
 None
 1.28A 3bjwG-5hj7A:
undetectable		 3bjwG-5hj7A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n29 CTP SYNTHASE

(Trypanosoma
brucei) 		PF00117
(GATase) 		4 VAL A 474
VAL A 494
THR A 562
THR A 522
 None
 1.16A 3bjwG-5n29A:
undetectable		 3bjwG-5n29A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL I 540
VAL I 454
THR I 377
THR I 538
 None
 1.24A 3bjwG-5o32I:
undetectable		 3bjwG-5o32I:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		4 VAL F 397
VAL F 396
THR F  57
THR F 399
 NFU  F 501 (-4.4A)
None
None
NFU  F 501 (-3.7A)
 1.18A 3bjwG-5odrF:
undetectable		 3bjwG-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		4 VAL F 396
VAL F 397
THR E 114
THR F 377
 None
NFU  F 501 (-4.4A)
None
None
 1.23A 3bjwG-5odrF:
undetectable		 3bjwG-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 VAL A 208
VAL A 153
THR A 127
THR A 210
 None
 1.27A 3bjwG-5opfA:
undetectable		 3bjwG-5opfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5w INTERFERON LAMBDA
RECEPTOR 1

(Homo sapiens) 		PF01108
(Tissue_fac) 		4 VAL B  80
VAL B  37
THR B  11
THR B  82
 None
 1.21A 3bjwG-5t5wB:
undetectable		 3bjwG-5t5wB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpk PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 VAL A 805
VAL A 806
THR A 815
THR A 892
 None
 1.23A 3bjwG-5tpkA:
undetectable		 3bjwG-5tpkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 4 VAL B 161
VAL B 162
THR B 123
THR B 157
 None
 1.22A 3bjwG-5vqiB:
undetectable		 3bjwG-5vqiB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0s THERMOTOGA MARITIMA
TMCAL

(Thermotoga
maritima) 		no annotation 4 VAL A  66
VAL A  67
THR A  93
THR A 343
 None
 1.22A 3bjwG-5y0sA:
undetectable		 3bjwG-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 VAL C1373
VAL C1371
THR C1417
THR C1375
 None
 1.27A 3bjwG-5y3rC:
undetectable		 3bjwG-5y3rC:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Bacillus
anthracis) 		no annotation 4 VAL A 252
VAL A 253
THR A 306
THR A 248
 None
 1.26A 3bjwG-6bi4A:
undetectable		 3bjwG-6bi4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 VAL A   7
VAL A  41
THR A 176
THR A   9
 None
 1.22A 3bjwG-6gnfA:
undetectable		 3bjwG-6gnfA:
undetectable