SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_E_SVRE503_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 SER A  28
PRO A  29
PHE A  59
PRO A  26
 None
 1.13A 3bjwG-1c4xA:
0.0		 3bjwG-1c4xA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		4 SER A  65
PRO A  66
PHE A  69
PRO A  64
 None
 1.49A 3bjwG-2dt8A:
0.0		 3bjwG-2dt8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5i UPF0249 PROTEIN
EF_3048

(Enterococcus
faecalis) 		PF04794
(YdjC) 		4 SER A  41
PRO A  42
PHE A  44
PRO A  39
 None
 1.34A 3bjwG-2i5iA:
0.0		 3bjwG-2i5iA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 SER A 259
PRO A 261
PHE A 190
PRO A 263
 None
 1.17A 3bjwG-3kmuA:
0.0		 3bjwG-3kmuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 SER A 194
PRO A 193
PHE A 226
PRO A 200
 None
 1.49A 3bjwG-3kt4A:
0.0		 3bjwG-3kt4A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 SER A  69
PRO A  70
PHE A  91
PRO A  68
 None
 1.47A 3bjwG-3lkwA:
0.0		 3bjwG-3lkwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwx PUTATIVE FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Vibrio
parahaemolyticus) 		PF00669
(Flagellin_N) 		4 SER A 205
PRO A 206
PHE A 208
PRO A 204
 None
 1.48A 3bjwG-3pwxA:
1.8		 3bjwG-3pwxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 SER A 174
PRO A 175
PHE A 177
PRO A 173
 None
 1.34A 3bjwG-3u78A:
0.0		 3bjwG-3u78A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 SER A 114
PRO A 115
PHE A 117
PRO A 112
 None
 1.43A 3bjwG-4tnbA:
0.0		 3bjwG-4tnbA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhz PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		4 SER A 795
PRO A 796
PHE A 878
PRO A 886
 None
 1.32A 3bjwG-4xhzA:
undetectable		 3bjwG-4xhzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		4 SER A 223
PRO A 224
PHE A 227
PRO A 220
 None
 1.39A 3bjwG-5ul4A:
undetectable		 3bjwG-5ul4A:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 4 SER B 531
PRO B 533
PHE B 534
PRO B 529
 None
 1.35A 3bjwG-6b4jB:
undetectable		 3bjwG-6b4jB:
16.39