SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_C_SVRC507

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
16vp PROTEIN (VP16,
VMW65, ATIF)

(Human
alphaherpesvirus
1) 		PF02232
(Alpha_TIF) 		4 VAL A 112
VAL A 113
GLY A 116
ARG A 208
 None
 0.85A 3bjwC-16vpA:
0.0		 3bjwC-16vpA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		4 VAL A 120
VAL A 119
GLY A 122
ARG A  26
 None
 0.88A 3bjwC-1bgpA:
0.0		 3bjwC-1bgpA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsz PROTEIN (PEPTIDE
DEFORMYLASE)

(Escherichia
coli) 		PF01327
(Pep_deformylase) 		4 VAL A  16
VAL A 138
GLY A 139
ARG A  56
 None
 0.90A 3bjwC-1bszA:
undetectable		 3bjwC-1bszA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.73A 3bjwC-1hsjA:
0.0		 3bjwC-1hsjA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.77A 3bjwC-1mg1A:
undetectable		 3bjwC-1mg1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu2 DISABLED HOMOLOG 1

(Mus musculus) 		PF00640
(PID) 		4 VAL A  71
VAL A  72
GLY A  74
LYS A  67
 None
 0.97A 3bjwC-1nu2A:
0.0		 3bjwC-1nu2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 4 VAL P 109
GLY P 299
PRO P 228
LYS P 304
 None
 0.79A 3bjwC-1r6zP:
0.0		 3bjwC-1r6zP:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.72A 3bjwC-1y4cA:
undetectable		 3bjwC-1y4cA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2def PEPTIDE DEFORMYLASE

(Escherichia
coli) 		PF01327
(Pep_deformylase) 		4 VAL A  16
VAL A 138
GLY A 139
ARG A  56
 None
 0.96A 3bjwC-2defA:
undetectable		 3bjwC-2defA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4v CYSTATIN

(Ananas comosus) 		PF16845
(SQAPI) 		4 VAL A  90
VAL A  91
GLY A  93
LYS A 114
 None
 0.98A 3bjwC-2l4vA:
undetectable		 3bjwC-2l4vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 VAL A   7
VAL A   8
GLY A  75
PRO A  99
 None
 0.96A 3bjwC-2livA:
undetectable		 3bjwC-2livA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 VAL A   2
VAL A   3
GLY A   6
PRO A  18
ARG A  72
 None
 1.39A 3bjwC-2qheA:
22.8		 3bjwC-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 VAL A  17
VAL A  18
GLY A  21
ARG A  15
 None
 0.85A 3bjwC-2vdcA:
undetectable		 3bjwC-2vdcA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.72A 3bjwC-2vgqA:
undetectable		 3bjwC-2vgqA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA

(Aspergillus
nidulans) 		PF05368
(NmrA) 		4 VAL A 268
VAL A 267
GLY A 270
PRO A 180
 None
 0.95A 3bjwC-2vutA:
undetectable		 3bjwC-2vutA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 VAL A 136
GLY A 326
PRO A 255
LYS A 331
 None
 0.76A 3bjwC-2xz3A:
undetectable		 3bjwC-2xz3A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 VAL A 290
VAL A 291
GLY A 293
PRO A 251
 None
 0.94A 3bjwC-2yevA:
1.0		 3bjwC-2yevA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.90A 3bjwC-3a3cA:
undetectable		 3bjwC-3a3cA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b02 TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A  72
GLY A  26
PRO A  47
LYS A   1
 None
 0.90A 3bjwC-3b02A:
undetectable		 3bjwC-3b02A:
17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 VAL A   2
GLY A   6
PRO A  17
LYS A  60
ARG A  63
 None
 1.19A 3bjwC-3dihA:
22.1		 3bjwC-3dihA:
64.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.72A 3bjwC-3dm0A:
undetectable		 3bjwC-3dm0A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A-239
GLY A -49
PRO A-120
LYS A -44
 None
 0.66A 3bjwC-3ehsA:
undetectable		 3bjwC-3ehsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.74A 3bjwC-3f5fA:
undetectable		 3bjwC-3f5fA:
9.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 GLY A   6
PRO A  17
LYS A  60
ARG A  63
 None
 0.74A 3bjwC-3g8gA:
21.3		 3bjwC-3g8gA:
63.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 VAL A 224
VAL A 219
GLY A 220
ARG A 217
 None
 0.97A 3bjwC-3go7A:
undetectable		 3bjwC-3go7A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 VAL A 206
GLY A 209
PRO A 320
LYS A 202
 None
 0.94A 3bjwC-3h4lA:
undetectable		 3bjwC-3h4lA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.71A 3bjwC-3h4zA:
undetectable		 3bjwC-3h4zA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9c TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF13377
(Peripla_BP_3) 		4 VAL A 152
VAL A 153
GLY A 133
PRO A 197
 None
 0.92A 3bjwC-3k9cA:
undetectable		 3bjwC-3k9cA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A-234
GLY A -44
PRO A-115
LYS A -39
 None
 0.78A 3bjwC-3l2jA:
undetectable		 3bjwC-3l2jA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 VAL A 848
GLY A1038
PRO A 967
LYS A1043
 None
 0.75A 3bjwC-3mp6A:
undetectable		 3bjwC-3mp6A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A-260
GLY A -70
PRO A-141
LYS A -65
 None
 0.73A 3bjwC-3n93A:
undetectable		 3bjwC-3n93A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A-238
GLY A -48
PRO A-119
LYS A -43
 None
 0.66A 3bjwC-3n94A:
undetectable		 3bjwC-3n94A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		4 VAL N 110
GLY N 300
PRO N 229
LYS N 305
 None
 0.66A 3bjwC-3o3uN:
undetectable		 3bjwC-3o3uN:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.68A 3bjwC-3oaiA:
undetectable		 3bjwC-3oaiA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.61A 3bjwC-3ob4A:
undetectable		 3bjwC-3ob4A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 548
PRO A 477
LYS A 553
 None
 0.78A 3bjwC-3osqA:
undetectable		 3bjwC-3osqA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.70A 3bjwC-3osrA:
undetectable		 3bjwC-3osrA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-3py7A:
undetectable		 3bjwC-3py7A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.66A 3bjwC-3vd8A:
undetectable		 3bjwC-3vd8A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		4 VAL A 216
GLY A  40
LYS A 219
ARG A 244
 None
 0.75A 3bjwC-3vr0A:
undetectable		 3bjwC-3vr0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.68A 3bjwC-4b3nA:
undetectable		 3bjwC-4b3nA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 VAL A1804
VAL A1805
GLY A1808
PRO B  59
 None
 0.90A 3bjwC-4by6A:
undetectable		 3bjwC-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 VAL A 544
VAL A 545
GLY A 547
ARG A 571
 None
 0.66A 3bjwC-4c51A:
undetectable		 3bjwC-4c51A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 VAL A 544
VAL A 545
GLY A 548
ARG A 571
 None
 0.88A 3bjwC-4c51A:
undetectable		 3bjwC-4c51A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.91A 3bjwC-4dxbA:
undetectable		 3bjwC-4dxbA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.65A 3bjwC-4edqA:
undetectable		 3bjwC-4edqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.77A 3bjwC-4egcA:
2.0		 3bjwC-4egcA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.70A 3bjwC-4exkA:
undetectable		 3bjwC-4exkA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-4gizA:
undetectable		 3bjwC-4gizA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 VAL A-260
GLY A -70
PRO A-141
LYS A -65
 None
 0.71A 3bjwC-4h1gA:
undetectable		 3bjwC-4h1gA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 VAL A 111
GLY A  91
PRO A 192
ARG A 109
 None
None
CAF  A 169 ( 4.9A)
None
 0.93A 3bjwC-4h5uA:
undetectable		 3bjwC-4h5uA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.70A 3bjwC-4ifpA:
undetectable		 3bjwC-4ifpA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.87A 3bjwC-4ikmA:
undetectable		 3bjwC-4ikmA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.68A 3bjwC-4irlA:
undetectable		 3bjwC-4irlA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H  93
VAL H 102
GLY H 104
PRO L  43
ARG H  94
 None
 1.24A 3bjwC-4ktdH:
undetectable		 3bjwC-4ktdH:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.71A 3bjwC-4kv3A:
undetectable		 3bjwC-4kv3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.79A 3bjwC-4my2A:
undetectable		 3bjwC-4my2A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.74A 3bjwC-4nufA:
undetectable		 3bjwC-4nufA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.68A 3bjwC-4pe2A:
undetectable		 3bjwC-4pe2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 VAL A-261
GLY A -71
PRO A-142
LYS A -66
 None
 0.70A 3bjwC-4qszA:
undetectable		 3bjwC-4qszA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-4qvhA:
undetectable		 3bjwC-4qvhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.67A 3bjwC-4rwfA:
2.0		 3bjwC-4rwfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.73A 3bjwC-4tsmA:
undetectable		 3bjwC-4tsmA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		4 VAL A 191
VAL A 190
PRO A 153
ARG A 287
 None
 0.92A 3bjwC-4wh3A:
1.2		 3bjwC-4wh3A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 VAL A 134
GLY A 324
PRO A 253
LYS A 329
 None
 0.78A 3bjwC-4wrnA:
undetectable		 3bjwC-4wrnA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 VAL A 116
GLY A 306
PRO A 235
LYS A 311
 None
 0.75A 3bjwC-4wviA:
undetectable		 3bjwC-4wviA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 4 VAL D  91
VAL D  92
GLY D  96
PRO D  58
 None
 0.93A 3bjwC-4x28D:
undetectable		 3bjwC-4x28D:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.66A 3bjwC-4xa2A:
undetectable		 3bjwC-4xa2A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.68A 3bjwC-4xaiA:
undetectable		 3bjwC-4xaiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.64A 3bjwC-4xajA:
undetectable		 3bjwC-4xajA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.80A 3bjwC-5azaA:
1.6		 3bjwC-5azaA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.69A 3bjwC-5c7rA:
undetectable		 3bjwC-5c7rA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Acinetobacter
nosocomialis;
Escherichia
coli) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.72A 3bjwC-5cfvA:
undetectable		 3bjwC-5cfvA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.79A 3bjwC-5dfmA:
undetectable		 3bjwC-5dfmA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 VAL A 202
GLY A 204
LYS A 217
ARG A 219
 None
 0.90A 3bjwC-5e8hA:
undetectable		 3bjwC-5e8hA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 VAL B 218
GLY B 408
PRO B 337
LYS B 413
 None
 0.69A 3bjwC-5eduB:
undetectable		 3bjwC-5eduB:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		4 VAL A-262
GLY A -72
PRO A-143
LYS A -67
 None
 0.75A 3bjwC-5fsgA:
undetectable		 3bjwC-5fsgA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.73A 3bjwC-5gpqA:
undetectable		 3bjwC-5gpqA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.72A 3bjwC-5h7nA:
undetectable		 3bjwC-5h7nA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
NA  A 507 (-3.5A)
None
None
 0.67A 3bjwC-5hz7A:
undetectable		 3bjwC-5hz7A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 VAL A 477
GLY A 667
PRO A 596
LYS A 672
 None
 0.84A 3bjwC-5hzvA:
undetectable		 3bjwC-5hzvA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 VAL A 165
GLY A 355
PRO A 284
LYS A 360
 None
 0.76A 3bjwC-5hzwA:
undetectable		 3bjwC-5hzwA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 VAL A3777
GLY A3967
PRO A3896
LYS A3972
 None
 0.76A 3bjwC-5ii5A:
undetectable		 3bjwC-5ii5A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 VAL A4079
GLY A4269
PRO A4198
LYS A4274
 None
 0.75A 3bjwC-5iicA:
undetectable		 3bjwC-5iicA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 4 VAL C 110
GLY C 300
PRO C 229
LYS C 305
 None
 0.71A 3bjwC-5jj4C:
undetectable		 3bjwC-5jj4C:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		4 VAL A-259
GLY A -69
PRO A-140
LYS A -64
 None
 0.67A 3bjwC-5jonA:
undetectable		 3bjwC-5jonA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 VAL B  41
VAL B  42
GLY B  44
PRO B 187
 None
 0.87A 3bjwC-5lb3B:
undetectable		 3bjwC-5lb3B:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-5osqA:
undetectable		 3bjwC-5osqA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.74A 3bjwC-5t03A:
undetectable		 3bjwC-5t03A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.76A 3bjwC-5tj2A:
3.5		 3bjwC-5tj2A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		4 VAL A 116
GLY A 306
PRO A 235
LYS A 311
 None
 0.73A 3bjwC-5ttdA:
undetectable		 3bjwC-5ttdA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.74A 3bjwC-5v6yA:
undetectable		 3bjwC-5v6yA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		5 VAL A  47
VAL A  48
GLY A  61
PRO A  98
ARG A  31
 None
 1.17A 3bjwC-5vipA:
undetectable		 3bjwC-5vipA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.71A 3bjwC-5wq6A:
undetectable		 3bjwC-5wq6A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 VAL A 564
GLY A 531
PRO A 544
ARG A 563
 None
None
EDO  A1804 (-4.8A)
None
 0.96A 3bjwC-5x7sA:
undetectable		 3bjwC-5x7sA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US4

(Toxoplasma
gondii) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 VAL J 172
GLY J 170
PRO J 163
ARG J 175
 A  2 510 ( 4.6A)
U  2 512 ( 3.4A)
U  2 512 ( 4.4A)
A  2 537 ( 3.8A)
 0.84A 3bjwC-5xxuJ:
undetectable		 3bjwC-5xxuJ:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.56A 3bjwC-5z0rA:
undetectable		 3bjwC-5z0rA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 VAL A 190
GLY A 380
PRO A 309
LYS A 385
 None
 0.77A 3bjwC-6anvA:
undetectable		 3bjwC-6anvA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 4 VAL A   3
GLY A   6
PRO A  18
ARG A  72
 None
PE4  A 201 (-3.3A)
PE4  A 201 (-4.6A)
None
 0.76A 3bjwC-6ce2A:
20.0		 3bjwC-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 VAL A-105
GLY A  85
PRO A  14
LYS A  90
 6AK  A 403 ( 4.9A)
None
None
6AK  A 403 ( 4.1A)
 0.72A 3bjwC-6dm8A:
undetectable		 3bjwC-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 VAL A 513
VAL A 320
PHE A 276
ARG A 454
 None
None
None
FAD  A 750 (-3.8A)
 1.19A 3bjwF-1amoA:
0.0		 3bjwF-1amoA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 VAL A  18
VAL A  65
GLN A 104
ARG A  17
 None
 0.97A 3bjwF-1gr0A:
0.0		 3bjwF-1gr0A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 VAL A 423
GLN A 436
PHE A 419
ARG A 426
 None
 1.13A 3bjwF-1k25A:
0.0		 3bjwF-1k25A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n26 IL-6 RECEPTOR ALPHA
CHAIN

(Homo sapiens) 		PF00047
(ig)
PF09240
(IL6Ra-bind) 		4 VAL A 171
VAL A 131
PHE A 168
ARG A   4
 None
 1.25A 3bjwF-1n26A:
0.0		 3bjwF-1n26A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 VAL A 440
GLN A 471
PHE A 477
ARG A 439
 None
 1.22A 3bjwF-1n5xA:
0.0		 3bjwF-1n5xA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 VAL A 114
GLN A 328
PHE A 566
ARG A 256
 None
None
152  A5001 (-3.3A)
None
 1.19A 3bjwF-1ndfA:
0.0		 3bjwF-1ndfA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 VAL A 314
VAL A 315
PHE A 262
ARG A 378
 None
 0.94A 3bjwF-1oduA:
0.0		 3bjwF-1oduA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 VAL A 274
VAL A 221
GLN A 139
ARG A 118
 None
 1.25A 3bjwF-1pjaA:
0.0		 3bjwF-1pjaA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 VAL A 483
PHE A 452
ARG A 512
ARG A 520
 None
None
None
AMP  A1002 (-3.7A)
 1.24A 3bjwF-1qf6A:
0.0		 3bjwF-1qf6A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 VAL A 391
VAL A 390
ARG A 357
ARG A 481
 None
 1.14A 3bjwF-1ru3A:
undetectable		 3bjwF-1ru3A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 VAL A 530
VAL A 531
PHE A 509
ARG A 537
 None
 1.15A 3bjwF-1uaaA:
undetectable		 3bjwF-1uaaA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 251
VAL A 252
PHE A 215
ARG A 250
 None
None
None
SO4  A1434 (-4.0A)
 1.19A 3bjwF-1uypA:
undetectable		 3bjwF-1uypA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w97 TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio cholerae) 		PF05134
(T2SSL) 		4 VAL L  54
VAL L  55
PHE L 231
ARG L 119
 None
 0.86A 3bjwF-1w97L:
undetectable		 3bjwF-1w97L:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 VAL A 234
VAL A 235
PHE A 223
ARG A 260
 None
 1.15A 3bjwF-1wxxA:
undetectable		 3bjwF-1wxxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 VAL A 266
VAL A 267
PHE A 291
ARG A 210
 None
 1.06A 3bjwF-1x3wA:
undetectable		 3bjwF-1x3wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 VAL A 266
VAL A 267
PHE A 295
ARG A 210
 None
 0.92A 3bjwF-1x3wA:
undetectable		 3bjwF-1x3wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		4 VAL A  94
VAL A  89
ARG A  44
ARG A 108
 None
 1.24A 3bjwF-1xfgA:
undetectable		 3bjwF-1xfgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 VAL A 146
GLN A 272
PHE A 263
ARG A 147
 None
 1.01A 3bjwF-1yvlA:
undetectable		 3bjwF-1yvlA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 VAL A  73
VAL A  74
GLN A  82
PHE A  36
 None
 1.02A 3bjwF-1yvpA:
undetectable		 3bjwF-1yvpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		4 VAL A 216
VAL A 215
PHE A 183
ARG A 227
 None
 1.19A 3bjwF-1z9dA:
undetectable		 3bjwF-1z9dA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		4 VAL A   6
VAL A  27
PHE A  22
ARG A  44
 None
 1.22A 3bjwF-2as0A:
undetectable		 3bjwF-2as0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C

(;
Homo sapiens) 		no annotation 4 VAL B 174
GLN A 343
PHE A 381
ARG A 364
 None
 1.20A 3bjwF-2gkwB:
undetectable		 3bjwF-2gkwB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv5 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF10052
(DUF2288) 		4 VAL A  96
VAL A  97
GLN A  99
PHE A  31
 None
 1.22A 3bjwF-2lv5A:
undetectable		 3bjwF-2lv5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A1018
VAL A1017
ARG A 993
ARG A1012
 None
 1.15A 3bjwF-2nlkA:
undetectable		 3bjwF-2nlkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofq TRAO

(IncN plasmid
R46) 		PF03524
(CagX) 		4 VAL A 237
VAL A 236
GLN A 219
PHE A 206
 None
 1.23A 3bjwF-2ofqA:
undetectable		 3bjwF-2ofqA:
24.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
VAL A   3
GLN A  11
PHE A  19
 None
 0.56A 3bjwF-2qheA:
23.9		 3bjwF-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
VAL A   3
PHE A  19
ARG A  72
 None
 1.16A 3bjwF-2qheA:
23.9		 3bjwF-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 VAL A 288
PHE A 272
ARG A 287
ARG A 160
 None
 0.95A 3bjwF-2qzpA:
undetectable		 3bjwF-2qzpA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 VAL A  28
VAL A  95
GLN A 122
PHE A  25
 None
 1.14A 3bjwF-2r3bA:
undetectable		 3bjwF-2r3bA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 VAL A  27
VAL A  31
ARG A  33
ARG A 394
 None
 1.21A 3bjwF-2vr2A:
undetectable		 3bjwF-2vr2A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 671
PHE A 656
ARG A 618
ARG A 622
 None
 1.23A 3bjwF-2x40A:
undetectable		 3bjwF-2x40A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 VAL A 169
VAL A 170
GLN A 229
PHE A 215
 None
 1.22A 3bjwF-2y05A:
undetectable		 3bjwF-2y05A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 VAL A   6
VAL A   7
PHE A 329
ARG A   5
 None
 1.19A 3bjwF-2zb4A:
undetectable		 3bjwF-2zb4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 VAL A 288
GLN A 281
ARG A 255
ARG A 170
 None
 1.16A 3bjwF-3c4nA:
0.5		 3bjwF-3c4nA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dex SAV_2001

(Streptomyces
avermitilis) 		PF10262
(Rdx) 		4 VAL A  59
VAL A  58
PHE A  74
ARG A  60
 None
 1.24A 3bjwF-3dexA:
undetectable		 3bjwF-3dexA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 493
GLN A 482
PHE A 245
ARG A 495
 None
 1.25A 3bjwF-3dhvA:
undetectable		 3bjwF-3dhvA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 VAL A 493
VAL A 300
PHE A 256
ARG A 434
 None
None
None
FAD  A 750 (-3.9A)
 1.15A 3bjwF-3fjoA:
undetectable		 3bjwF-3fjoA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 VAL A 184
VAL A 133
GLN A 290
ARG A 185
 None
 1.16A 3bjwF-3g87A:
undetectable		 3bjwF-3g87A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl3 PUTATIVE
THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Chlorobaculum
tepidum) 		PF08534
(Redoxin) 		4 VAL A  56
GLN A  80
PHE A 136
ARG A 140
 None
 1.06A 3bjwF-3gl3A:
undetectable		 3bjwF-3gl3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4p TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Agrobacterium
fabrum) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		4 VAL A  92
VAL A  93
ARG A 107
ARG A  49
 None
None
None
CL  A 163 (-4.1A)
 1.09A 3bjwF-3i4pA:
undetectable		 3bjwF-3i4pA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 VAL A 311
PHE A 395
ARG A 339
ARG A 300
 None
 1.12A 3bjwF-3ipoA:
undetectable		 3bjwF-3ipoA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 VAL A 330
VAL A 331
PHE A 149
ARG A 329
 None
 1.10A 3bjwF-3j4uA:
undetectable		 3bjwF-3j4uA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5

(Plasmodium
falciparum) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 VAL G  92
VAL G  93
PHE G 110
ARG G 224
 None
 1.07A 3bjwF-3j7aG:
undetectable		 3bjwF-3j7aG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 VAL A 128
GLN A 192
ARG A 129
ARG A 162
 None
 1.17A 3bjwF-3k1tA:
undetectable		 3bjwF-3k1tA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 VAL A 321
VAL A 322
PHE A 202
ARG A 320
 None
 1.24A 3bjwF-3m6cA:
undetectable		 3bjwF-3m6cA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 VAL B1007
VAL B1006
GLN B1022
ARG B1018
 None
 1.20A 3bjwF-3myrB:
0.9		 3bjwF-3myrB:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 VAL A  21
VAL A  22
PHE A 131
ARG A  81
 None
 1.06A 3bjwF-3op1A:
undetectable		 3bjwF-3op1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 VAL A 287
PHE A 284
ARG A 103
ARG A 109
 None
 1.23A 3bjwF-3p8tA:
undetectable		 3bjwF-3p8tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5w PROTEIN CUT8

(Schizosaccharomyces
pombe) 		PF08559
(Cut8) 		4 VAL A 176
VAL A 175
PHE A 139
ARG A 178
 None
 1.21A 3bjwF-3q5wA:
1.1		 3bjwF-3q5wA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 VAL A 516
VAL A 323
PHE A 279
ARG A 457
 None
None
None
FAD  A 752 (-3.9A)
 1.26A 3bjwF-3qfsA:
undetectable		 3bjwF-3qfsA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 VAL A  99
VAL A  98
GLN A  71
PHE A  63
 None
 1.19A 3bjwF-3rd7A:
undetectable		 3bjwF-3rd7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		4 VAL A 210
GLN A 194
PHE A 217
ARG A  70
 None
 1.25A 3bjwF-3rp7A:
0.2		 3bjwF-3rp7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sns LIPOPROTEIN 34

(Escherichia
coli) 		PF06804
(Lipoprotein_18) 		4 VAL A 244
VAL A 243
GLN A 317
ARG A 313
 None
 1.09A 3bjwF-3snsA:
undetectable		 3bjwF-3snsA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 VAL A 435
VAL A 444
GLN A  66
PHE A 438
 None
 1.22A 3bjwF-3vi3A:
undetectable		 3bjwF-3vi3A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		4 VAL A 241
VAL A 240
PHE A 236
ARG A 276
 None
 1.13A 3bjwF-3vovA:
undetectable		 3bjwF-3vovA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 VAL A  83
VAL A  82
PHE A  35
ARG A  12
 None
 1.19A 3bjwF-3vr1A:
undetectable		 3bjwF-3vr1A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 288
VAL A 289
PHE A 319
ARG A 286
 None
 1.07A 3bjwF-4a0sA:
undetectable		 3bjwF-4a0sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		4 VAL A2048
VAL A2049
PHE A2055
ARG A2103
 None
 1.22A 3bjwF-4c0eA:
undetectable		 3bjwF-4c0eA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 VAL A 384
VAL A 383
GLN A 361
ARG A 351
 None
 1.12A 3bjwF-4dalA:
undetectable		 3bjwF-4dalA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyw MUTT/NUDIX FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF00293
(NUDIX) 		4 VAL A 100
VAL A 101
ARG A  99
ARG A  54
 None
 1.12A 3bjwF-4dywA:
undetectable		 3bjwF-4dywA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		4 VAL A1052
VAL A1051
GLN A1163
ARG A1044
 None
 1.23A 3bjwF-4f0gA:
undetectable		 3bjwF-4f0gA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2b SECRETED EFFECTOR
PROTEIN SSEI

(Salmonella
enterica) 		PF15645
(Tox-PLDMTX) 		4 VAL A 219
VAL A 220
PHE A 188
ARG A 200
 None
 1.16A 3bjwF-4g2bA:
undetectable		 3bjwF-4g2bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 VAL A 167
VAL A 166
GLN A 158
ARG A 170
 None
 1.20A 3bjwF-4iegA:
undetectable		 3bjwF-4iegA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 VAL A 252
VAL A 263
PHE A 182
ARG A 251
 None
 1.21A 3bjwF-4jklA:
undetectable		 3bjwF-4jklA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 VAL A 108
VAL A 107
GLN A  95
ARG A  52
 PQQ  A 602 (-4.8A)
None
None
None
 1.23A 3bjwF-4maeA:
undetectable		 3bjwF-4maeA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 VAL A 577
VAL A 576
PHE A 592
ARG A 569
 None
 1.14A 3bjwF-4mtkA:
undetectable		 3bjwF-4mtkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o26 TELOMERASE REVERSE
TRANSCRIPTASE

(Oryzias latipes) 		PF12009
(Telomerase_RBD) 		4 VAL A 350
GLN A 510
PHE A 519
ARG A 506
 None
None
None
U  E 182 ( 4.0A)
 1.19A 3bjwF-4o26A:
undetectable		 3bjwF-4o26A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 4 VAL A  67
VAL A  68
GLN A  28
PHE A  74
 None
 1.16A 3bjwF-4okmA:
undetectable		 3bjwF-4okmA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 VAL B 106
VAL B 107
GLN B 831
ARG B  73
 None
 1.26A 3bjwF-4qj4B:
undetectable		 3bjwF-4qj4B:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		4 VAL A 177
VAL A 176
PHE A   8
ARG A 185
 None
 0.95A 3bjwF-4uw9A:
undetectable		 3bjwF-4uw9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 VAL A 218
VAL A 219
GLN A 190
ARG A 230
 None
 1.14A 3bjwF-4w1wA:
undetectable		 3bjwF-4w1wA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 VAL A  19
VAL A  30
GLN A  65
PHE A  72
 None
None
None
CU1  A 503 (-4.4A)
 1.16A 3bjwF-5c92A:
undetectable		 3bjwF-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		4 VAL A 432
GLN A  30
PHE A 437
ARG A 428
 None
 1.17A 3bjwF-5dm3A:
undetectable		 3bjwF-5dm3A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 4 VAL A 426
GLN A 148
PHE A 152
ARG A 142
 None
 1.06A 3bjwF-5efvA:
undetectable		 3bjwF-5efvA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekp UNCHARACTERIZED
GLYCOSYLTRANSFERASE
SLL0501

(Synechocystis
sp. PCC 6803) 		no annotation 4 VAL C 165
VAL C 166
PHE C 183
ARG C 163
 None
 0.90A 3bjwF-5ekpC:
undetectable		 3bjwF-5ekpC:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er7 GAP JUNCTION BETA-2
PROTEIN

(Homo sapiens) 		no annotation 4 VAL B  38
VAL B  37
PHE B 194
ARG B  75
 None
 0.96A 3bjwF-5er7B:
1.4		 3bjwF-5er7B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		4 VAL A2208
VAL A2207
ARG A1981
ARG A2199
 None
 0.99A 3bjwF-5fbyA:
1.7		 3bjwF-5fbyA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 VAL L  36
VAL L  47
PHE L  98
ARG L  37
 None
 1.19A 3bjwF-5grvL:
undetectable		 3bjwF-5grvL:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 VAL C  36
VAL C  47
PHE C  98
ARG C  37
 None
 1.19A 3bjwF-5gs1C:
undetectable		 3bjwF-5gs1C:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 VAL A 134
VAL A 203
PHE A 211
ARG A 236
 None
 1.23A 3bjwF-5gw8A:
undetectable		 3bjwF-5gw8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyq SPIKE GLYCOPROTEIN

(Rousettus bat
coronavirus
HKU9) 		PF09408
(Spike_rec_bind) 		4 VAL A  22
VAL A  23
PHE A 121
ARG A  26
 None
 1.05A 3bjwF-5gyqA:
undetectable		 3bjwF-5gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 VAL A  33
VAL A  32
ARG A  52
ARG A  72
 None
 1.06A 3bjwF-5infA:
undetectable		 3bjwF-5infA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 VAL A 589
VAL A 590
ARG A 587
ARG A 687
 None
 1.04A 3bjwF-5jxkA:
undetectable		 3bjwF-5jxkA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		4 VAL A 373
VAL A 372
ARG A 233
ARG A 428
 None
 1.21A 3bjwF-5lqdA:
undetectable		 3bjwF-5lqdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 4 VAL A 167
PHE A 134
ARG A  43
ARG A 154
 None
LOC  A 201 (-3.8A)
None
None
 1.08A 3bjwF-5nknA:
undetectable		 3bjwF-5nknA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 VAL A 414
VAL A 413
ARG A 443
ARG A 249
 None
EDO  A 609 (-3.7A)
None
None
 1.24A 3bjwF-5nzgA:
undetectable		 3bjwF-5nzgA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB

(Saccharomyces
cerevisiae) 		no annotation 4 VAL 7 657
GLN 7 672
PHE 7 626
ARG 7 722
 None
 1.15A 3bjwF-5oqm7:
undetectable		 3bjwF-5oqm7:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 VAL C 860
VAL C 843
ARG C 842
ARG C 846
 None
 1.13A 3bjwF-5tw1C:
undetectable		 3bjwF-5tw1C:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 VAL A 145
GLN A 269
PHE A 260
ARG A 272
 None
 1.17A 3bjwF-5u39A:
undetectable		 3bjwF-5u39A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum) 		PF00765
(Autoind_synth) 		4 VAL A  64
VAL A  65
GLN A 118
ARG A  63
 None
 0.95A 3bjwF-5w8dA:
undetectable		 3bjwF-5w8dA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 4 VAL A 436
VAL A 445
GLN A 349
ARG A 437
 None
 1.17A 3bjwF-5wm4A:
undetectable		 3bjwF-5wm4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 4 VAL A 333
VAL A 334
ARG A 311
ARG A 337
 None
 1.09A 3bjwF-5wpwA:
undetectable		 3bjwF-5wpwA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 VAL A 452
VAL A 451
ARG A 454
ARG A  48
 None
None
None
G  B  70 ( 3.6A)
 1.14A 3bjwF-5x2gA:
undetectable		 3bjwF-5x2gA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 4 VAL B 363
VAL B 364
GLN B 372
PHE B 319
 None
 0.98A 3bjwF-5xyjB:
undetectable		 3bjwF-5xyjB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 VAL A 181
VAL A 182
GLN A 188
PHE A 373
 None
 1.16A 3bjwF-5ybbA:
undetectable		 3bjwF-5ybbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt4 GALECTIN-10

(Homo sapiens) 		no annotation 4 VAL A  62
VAL A  63
ARG A  61
ARG A  67
 None
 1.25A 3bjwF-5yt4A:
undetectable		 3bjwF-5yt4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 VAL A 216
VAL A 215
GLN A 208
ARG A 218
 None
 1.25A 3bjwF-6b5fA:
undetectable		 3bjwF-6b5fA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 4 VAL E 275
GLN E 206
PHE E 248
ARG E 274
 None
 1.24A 3bjwF-6bm7E:
undetectable		 3bjwF-6bm7E:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs9 STAGE III
SPORULATION PROTEIN
AB

(Bacillus
subtilis) 		no annotation 4 VAL A  97
GLN A  34
PHE A  75
ARG A  30
 None
 1.22A 3bjwF-6bs9A:
1.6		 3bjwF-6bs9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 4 VAL A 331
PHE A 321
ARG A 339
ARG A 312
 None
 1.05A 3bjwF-6c90A:
undetectable		 3bjwF-6c90A:
20.66