SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_C_SVRC505

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 GLU A1004
GLY A1006
PRO A1017
LYS A1069
ARG A1072
 None
IPA  A1136 (-3.6A)
IPA  A1136 (-4.4A)
None
None
 1.15A 3bjwD-1mc2A:
19.9		 3bjwD-1mc2A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 VAL A  70
GLU A  73
GLY A  68
THR A  54
ARG A  42
 None
 1.44A 3bjwD-1pyfA:
undetectable		 3bjwD-1pyfA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		5 GLU A  40
GLY A  42
LYS A  43
PRO A  52
THR A  53
 None
 1.24A 3bjwD-1wrkA:
undetectable		 3bjwD-1wrkA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 VAL A 120
VAL A 119
GLY A 146
PRO A 178
THR A 176
 None
 1.50A 3bjwD-1yv9A:
0.0		 3bjwD-1yv9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 385
GLU A  87
GLY A 387
THR A 201
ARG A  90
 None
 1.29A 3bjwD-2cvoA:
0.0		 3bjwD-2cvoA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 VAL A 549
GLY A 550
PRO A 583
THR A 584
ARG A 501
 None
 1.39A 3bjwD-2o1xA:
undetectable		 3bjwD-2o1xA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		5 VAL A 184
VAL A 157
GLY A 155
PRO A 153
THR A 180
 None
 1.26A 3bjwD-2ph1A:
undetectable		 3bjwD-2ph1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 329
GLU A  31
GLY A 331
THR A 145
ARG A  34
 None
 1.29A 3bjwD-2q49A:
0.0		 3bjwD-2q49A:
15.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		6 VAL A   2
VAL A   3
GLU A   4
GLY A   6
PRO A  18
THR A  23
 None
 0.61A 3bjwD-2qheA:
22.8		 3bjwD-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLU A 102
GLY A 105
LYS A 106
THR A 395
ARG A 333
 None
 1.49A 3bjwD-2wbiA:
0.0		 3bjwD-2wbiA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 VAL A 151
GLU A 184
GLY A 155
ARG A 180
LYS A 183
 None
 1.49A 3bjwD-3b4uA:
undetectable		 3bjwD-3b4uA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 VAL A   2
GLU A   4
GLY A   6
PRO A  17
LYS A  60
 None
 0.93A 3bjwD-3dihA:
22.0		 3bjwD-3dihA:
64.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 VAL A 273
VAL A 274
GLU A 275
GLY A 276
LYS A 541
 None
 1.47A 3bjwD-3g4fA:
undetectable		 3bjwD-3g4fA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 GLU A 334
GLY A 361
PRO A  75
ARG A  40
LYS A 335
 None
 1.37A 3bjwD-3r67A:
undetectable		 3bjwD-3r67A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		5 GLU A 342
GLY A 369
PRO A  83
ARG A  49
LYS A 343
 None
 1.41A 3bjwD-3tawA:
undetectable		 3bjwD-3tawA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		5 VAL A1804
VAL A1805
GLY A1808
PRO B  59
THR B  63
 None
 0.96A 3bjwD-4by6A:
undetectable		 3bjwD-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d01 NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-9

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 VAL A  30
VAL A 158
GLY A 155
PRO A 198
LYS A  29
 None
 1.47A 3bjwD-4d01A:
undetectable		 3bjwD-4d01A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esy CBS DOMAIN
CONTAINING MEMBRANE
PROTEIN

(Sphaerobacter
thermophilus) 		PF00571
(CBS) 		5 VAL A 357
GLU A 328
GLY A 358
PRO A 409
THR A 412
 None
 1.45A 3bjwD-4esyA:
undetectable		 3bjwD-4esyA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 3A,
CHLOROPLASTIC

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		5 GLU A 234
LYS A 236
PRO A 263
ARG A 167
LYS S  11
 None
 1.28A 3bjwD-4mkvA:
undetectable		 3bjwD-4mkvA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 VAL A 398
VAL A 399
GLU A 400
GLY A 402
THR A 389
 None
 1.19A 3bjwD-5ks8A:
undetectable		 3bjwD-5ks8A:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		5 GLU A   4
LYS A   7
PRO A  18
THR A  23
ARG A  72
 None
 1.10A 3bjwD-5tfvA:
20.9		 3bjwD-5tfvA:
59.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		5 GLU A   4
LYS A   7
PRO A  18
THR A  23
LYS A  69
 None
 0.66A 3bjwD-5tfvA:
20.9		 3bjwD-5tfvA:
59.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 VAL A 301
GLU A 359
GLY A 299
LYS A 322
ARG A 311
 None
 1.41A 3bjwD-5vniA:
undetectable		 3bjwD-5vniA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 VAL A 125
GLU A 689
GLY A 118
THR A  74
ARG A 140
 None
 1.15A 3bjwD-5xgjA:
undetectable		 3bjwD-5xgjA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 VAL A 611
VAL A 610
GLY A 607
LYS A 606
THR A 536
 None
 1.48A 3bjwD-5yfbA:
undetectable		 3bjwD-5yfbA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 5 VAL A   3
GLU A   4
GLY A   6
LYS A  69
ARG A  72
 None
None
PE4  A 201 (-3.3A)
None
None
 1.21A 3bjwD-6ce2A:
20.1		 3bjwD-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 5 VAL A   3
GLU A   4
GLY A   6
PRO A  18
ARG A  72
 None
None
PE4  A 201 (-3.3A)
PE4  A 201 (-4.6A)
None
 1.14A 3bjwD-6ce2A:
20.1		 3bjwD-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 VAL A 686
GLN A 602
PHE A 606
ARG A 681
 None
 1.35A 3bjwH-1ldjA:
0.4		 3bjwH-1ldjA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 VAL A 410
VAL A 411
PHE A 427
ARG A 350
 None
None
None
AEP  A 683 (-2.8A)
 1.25A 3bjwH-1lfwA:
0.0		 3bjwH-1lfwA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 VAL A 274
VAL A 273
PHE A 187
ARG A 270
 None
None
BP6  A 300 (-4.3A)
None
 1.32A 3bjwH-1lkdA:
0.0		 3bjwH-1lkdA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 260
VAL A 175
GLN A 196
ARG A 191
 None
 1.27A 3bjwH-1lvlA:
0.0		 3bjwH-1lvlA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A  37
VAL A  36
GLN A  81
PHE A  54
 None
 1.37A 3bjwH-1moxA:
0.0		 3bjwH-1moxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 VAL A 314
VAL A 315
PHE A 262
ARG A 378
 None
 0.99A 3bjwH-1oduA:
0.0		 3bjwH-1oduA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 VAL A 274
VAL A 221
GLN A 139
ARG A 118
 None
 1.20A 3bjwH-1pjaA:
0.0		 3bjwH-1pjaA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans) 		PF00510
(COX3) 		4 VAL C  69
VAL C  70
GLN C 243
PHE C  90
 PC1  C 302 (-4.2A)
PC1  C 302 (-4.3A)
PC1  C 302 (-2.9A)
PC1  C 302 (-4.4A)
 1.37A 3bjwH-1qleC:
0.5		 3bjwH-1qleC:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s21 ORF2

(Pseudomonas
savastanoi) 		PF09143
(AvrPphF-ORF-2) 		4 VAL A 171
VAL A 190
GLN A 167
ARG A 196
 None
 1.16A 3bjwH-1s21A:
undetectable		 3bjwH-1s21A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 VAL A 230
VAL A 231
PHE A 184
ARG A  48
 None
None
None
SO4  A 401 (-3.9A)
 1.35A 3bjwH-1t9kA:
undetectable		 3bjwH-1t9kA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w97 TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio cholerae) 		PF05134
(T2SSL) 		4 VAL L  54
VAL L  55
PHE L 231
ARG L 119
 None
 0.84A 3bjwH-1w97L:
undetectable		 3bjwH-1w97L:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrm DUAL SPECIFICITY
PHOSPHATASE 22

(Homo sapiens) 		PF00782
(DSPc) 		4 VAL A  99
VAL A  96
GLN A 132
PHE A 109
 None
 1.36A 3bjwH-1wrmA:
undetectable		 3bjwH-1wrmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 VAL A  73
VAL A  74
GLN A  82
PHE A  36
 None
 1.08A 3bjwH-1yvpA:
undetectable		 3bjwH-1yvpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		4 VAL A 216
VAL A 215
PHE A 183
ARG A 227
 None
 1.36A 3bjwH-1z9dA:
undetectable		 3bjwH-1z9dA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 VAL A 107
VAL A  59
GLN A  67
PHE A 104
 None
 1.34A 3bjwH-2b39A:
undetectable		 3bjwH-2b39A:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 VAL A  96
GLN A  68
PHE A 114
ARG A 522
 None
 1.28A 3bjwH-2bf4A:
undetectable		 3bjwH-2bf4A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE

(Staphylococcus
aureus) 		PF02152
(FolB) 		4 VAL A  37
VAL A  91
PHE A   6
ARG A 118
 None
 1.39A 3bjwH-2dhnA:
undetectable		 3bjwH-2dhnA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		4 VAL A 162
VAL A 163
GLN A 208
ARG A 215
 None
 1.33A 3bjwH-2e87A:
undetectable		 3bjwH-2e87A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2e PA1607

(Pseudomonas
aeruginosa) 		PF01638
(HxlR) 		4 VAL A  62
VAL A  68
PHE A  40
ARG A  87
 None
 1.31A 3bjwH-2f2eA:
undetectable		 3bjwH-2f2eA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 VAL A 217
VAL A 243
PHE A 102
ARG A 260
 None
 1.30A 3bjwH-2ffhA:
undetectable		 3bjwH-2ffhA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		4 VAL A 280
VAL A  19
GLN A  49
PHE A 286
 None
 1.11A 3bjwH-2fiqA:
0.4		 3bjwH-2fiqA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  93
VAL A  94
GLN A 124
PHE A 163
 None
 1.37A 3bjwH-2hlpA:
undetectable		 3bjwH-2hlpA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A 176
VAL A 177
GLN A  85
ARG A 190
 None
 1.29A 3bjwH-2ho4A:
undetectable		 3bjwH-2ho4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		4 VAL A  99
GLN A  83
PHE A 155
ARG A  91
 None
 1.29A 3bjwH-2jbwA:
undetectable		 3bjwH-2jbwA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lul TYROSINE-PROTEIN
KINASE TEC

(Homo sapiens) 		PF00169
(PH)
PF00779
(BTK) 		4 VAL A  72
VAL A  92
GLN A  26
ARG A  24
 None
 1.37A 3bjwH-2lulA:
undetectable		 3bjwH-2lulA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv5 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF10052
(DUF2288) 		4 VAL A  96
VAL A  97
GLN A  99
PHE A  31
 None
 1.29A 3bjwH-2lv5A:
undetectable		 3bjwH-2lv5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofq TRAO

(IncN plasmid
R46) 		PF03524
(CagX) 		4 VAL A 237
VAL A 236
GLN A 219
PHE A 206
 None
 1.32A 3bjwH-2ofqA:
undetectable		 3bjwH-2ofqA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 VAL A 201
VAL A   9
PHE A 363
ARG A  35
 None
None
None
FAD  A 401 ( 4.2A)
 1.32A 3bjwH-2q6uA:
undetectable		 3bjwH-2q6uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 843
VAL A 943
PHE A 885
ARG A 775
 None
 1.37A 3bjwH-2qepA:
undetectable		 3bjwH-2qepA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
VAL A   3
GLN A  11
PHE A  19
 None
 0.60A 3bjwH-2qheA:
23.8		 3bjwH-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmw PREPHENATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF00800
(PDT) 		4 VAL A  51
VAL A  50
PHE A  74
ARG A  80
 None
 1.26A 3bjwH-2qmwA:
undetectable		 3bjwH-2qmwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 VAL A  28
VAL A  95
GLN A 122
PHE A  25
 None
 1.08A 3bjwH-2r3bA:
undetectable		 3bjwH-2r3bA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 VAL A 410
VAL A 411
GLN A 431
ARG A 415
 None
 1.37A 3bjwH-2r7dA:
undetectable		 3bjwH-2r7dA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		4 VAL A 176
VAL A 173
GLN A 170
PHE A 182
 None
 1.30A 3bjwH-3a8rA:
undetectable		 3bjwH-3a8rA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 408
VAL A 407
PHE A 387
ARG A  25
 None
 1.23A 3bjwH-3aoeA:
0.1		 3bjwH-3aoeA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 VAL A 225
VAL A 226
GLN A 214
PHE A 192
 None
 1.38A 3bjwH-3b9eA:
undetectable		 3bjwH-3b9eA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		4 VAL A  55
VAL A  27
GLN A 122
PHE A  24
 None
 1.34A 3bjwH-3bgkA:
undetectable		 3bjwH-3bgkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs6 INNER MEMBRANE
PROTEIN OXAA

(Escherichia
coli) 		PF14849
(YidC_periplas) 		4 VAL A 253
GLN A 198
PHE A 193
ARG A 219
 None
None
PG4  A 336 (-3.9A)
None
 1.30A 3bjwH-3bs6A:
undetectable		 3bjwH-3bs6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		4 VAL A 235
VAL A 260
GLN A 249
PHE A 224
 None
 1.38A 3bjwH-3bt7A:
undetectable		 3bjwH-3bt7A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		4 VAL A  52
VAL A 135
PHE A 149
ARG A  48
 None
 1.37A 3bjwH-3cknA:
undetectable		 3bjwH-3cknA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		4 VAL A 134
VAL A 131
GLN A  81
ARG A  79
 None
 1.36A 3bjwH-3cpgA:
undetectable		 3bjwH-3cpgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		4 VAL A  98
VAL A  97
GLN A 130
ARG A  93
 None
 1.32A 3bjwH-3dt8A:
undetectable		 3bjwH-3dt8A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzm HYPOTHETICAL
CONSERVED PROTEIN

(Thermus
thermophilus) 		no annotation 4 VAL A  35
VAL A  23
GLN A  19
ARG A 200
 None
 1.34A 3bjwH-3dzmA:
undetectable		 3bjwH-3dzmA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		4 VAL C 151
VAL C 150
PHE C 263
ARG C  33
 None
 1.37A 3bjwH-3g65C:
undetectable		 3bjwH-3g65C:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkm OS03G0854200 PROTEIN

(Oryza sativa) 		PF01138
(RNase_PH) 		4 VAL A 170
VAL A 139
GLN A  35
ARG A  15
 None
 1.34A 3bjwH-3hkmA:
undetectable		 3bjwH-3hkmA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 VAL A 211
GLN A 335
PHE A 141
ARG A 220
 None
 1.33A 3bjwH-3i4xA:
undetectable		 3bjwH-3i4xA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5

(Plasmodium
falciparum) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 VAL G  92
VAL G  93
PHE G 110
ARG G 224
 None
 1.18A 3bjwH-3j7aG:
undetectable		 3bjwH-3j7aG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 VAL A 349
GLN A 332
PHE A  29
ARG A 335
 None
 1.37A 3bjwH-3kdnA:
undetectable		 3bjwH-3kdnA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		4 VAL A  39
VAL A  38
GLN A  36
PHE A 134
 None
 1.28A 3bjwH-3ki8A:
undetectable		 3bjwH-3ki8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A  37
VAL A  36
GLN A  81
PHE A  54
 None
 1.34A 3bjwH-3njpA:
undetectable		 3bjwH-3njpA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwz BH2602 PROTEIN

(Bacillus
halodurans) 		PF03061
(4HBT) 		4 VAL A 141
VAL A 142
PHE A 162
ARG A 100
 None
 1.39A 3bjwH-3nwzA:
undetectable		 3bjwH-3nwzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 VAL A  21
VAL A  22
PHE A 131
ARG A  81
 None
 1.18A 3bjwH-3op1A:
undetectable		 3bjwH-3op1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		4 VAL A 175
VAL A 176
GLN A 181
PHE A 113
 None
 1.32A 3bjwH-3r4vA:
undetectable		 3bjwH-3r4vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 VAL A  99
VAL A  98
GLN A  71
PHE A  63
 None
 1.23A 3bjwH-3rd7A:
undetectable		 3bjwH-3rd7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		4 VAL A 210
GLN A 194
PHE A 217
ARG A  70
 None
 1.28A 3bjwH-3rp7A:
0.0		 3bjwH-3rp7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 167
VAL A 166
GLN A 260
ARG A 206
 None
 1.39A 3bjwH-3t9wA:
undetectable		 3bjwH-3t9wA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 VAL A 165
VAL A 162
GLN A  65
ARG A 181
 None
 1.36A 3bjwH-3tg9A:
undetectable		 3bjwH-3tg9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF00106
(adh_short) 		4 VAL A  79
VAL A   9
GLN A  31
ARG A  49
 None
 1.37A 3bjwH-3tl3A:
undetectable		 3bjwH-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 VAL A 246
VAL A 245
PHE A  58
ARG A 336
 None
None
EDO  A 485 ( 4.9A)
None
 1.37A 3bjwH-3v7nA:
undetectable		 3bjwH-3v7nA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		4 VAL A  27
VAL A 122
GLN A  22
ARG A 126
 None
 1.33A 3bjwH-3w0fA:
undetectable		 3bjwH-3w0fA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		4 VAL A  36
VAL A 300
PHE A  53
ARG A 297
 None
None
None
B3P  A1560 (-2.8A)
 1.34A 3bjwH-3zxlA:
undetectable		 3bjwH-3zxlA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 VAL A 384
VAL A 383
GLN A 361
ARG A 351
 None
 1.09A 3bjwH-4dalA:
undetectable		 3bjwH-4dalA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 355
VAL A 354
GLN A 352
ARG A  14
 None
 1.39A 3bjwH-4dhgA:
undetectable		 3bjwH-4dhgA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 400
GLN A 253
PHE A 371
ARG A 395
 None
 1.36A 3bjwH-4f7kA:
undetectable		 3bjwH-4f7kA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgb PUTATIVE EXPORTED
PROTEIN

(Burkholderia
pseudomallei) 		PF13460
(NAD_binding_10) 		4 VAL A  64
VAL A  65
PHE A 150
ARG A  91
 None
 1.23A 3bjwH-4jgbA:
undetectable		 3bjwH-4jgbA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 VAL A 139
VAL A 138
PHE A 168
ARG A 212
 None
 1.37A 3bjwH-4knaA:
undetectable		 3bjwH-4knaA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 VAL A 214
VAL A 191
PHE A 211
ARG A  36
 None
 1.36A 3bjwH-4lgnA:
undetectable		 3bjwH-4lgnA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		4 VAL A 226
VAL A 223
GLN A  38
ARG A   2
 None
 1.39A 3bjwH-4n06A:
undetectable		 3bjwH-4n06A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 547
VAL A 603
GLN A 575
ARG A 622
 None
 1.28A 3bjwH-4nhoA:
undetectable		 3bjwH-4nhoA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o26 TELOMERASE REVERSE
TRANSCRIPTASE

(Oryzias latipes) 		PF12009
(Telomerase_RBD) 		4 VAL A 350
GLN A 510
PHE A 519
ARG A 506
 None
None
None
U  E 182 ( 4.0A)
 1.23A 3bjwH-4o26A:
undetectable		 3bjwH-4o26A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 VAL A 393
VAL A 394
GLN A 423
PHE A 352
 None
 1.27A 3bjwH-4pxnA:
undetectable		 3bjwH-4pxnA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri0 SERINE PROTEASE
HTRA3

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A 192
VAL A 193
GLN A 203
ARG A 360
 None
 1.22A 3bjwH-4ri0A:
undetectable		 3bjwH-4ri0A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94

(Drosophila
melanogaster) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 VAL A  84
VAL A  85
PHE A 160
ARG A  60
 None
 1.36A 3bjwH-4rv0A:
undetectable		 3bjwH-4rv0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3h MDB1

(Schizosaccharomyces
pombe) 		no annotation 4 VAL A  61
VAL A  54
PHE A  46
ARG A  51
 None
 1.34A 3bjwH-4s3hA:
undetectable		 3bjwH-4s3hA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron sp.) 		no annotation 4 VAL A1036
VAL A1037
GLN A1094
ARG A1024
 None
 1.38A 3bjwH-4uvqA:
undetectable		 3bjwH-4uvqA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		4 VAL A 177
VAL A 176
PHE A   8
ARG A 185
 None
 0.95A 3bjwH-4uw9A:
undetectable		 3bjwH-4uw9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 VAL A 218
VAL A 219
GLN A 190
ARG A 230
 None
 1.24A 3bjwH-4w1wA:
undetectable		 3bjwH-4w1wA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		4 VAL A 284
GLN A 294
PHE A 109
ARG A 291
 None
 1.35A 3bjwH-4y0eA:
undetectable		 3bjwH-4y0eA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 VAL A  19
VAL A  30
GLN A  65
PHE A  72
 None
None
None
CU1  A 503 (-4.4A)
 1.10A 3bjwH-5c92A:
undetectable		 3bjwH-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		4 VAL A 196
VAL A 195
PHE A 199
ARG A 139
 None
 1.39A 3bjwH-5d95A:
1.5		 3bjwH-5d95A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 4 VAL A 426
GLN A 148
PHE A 152
ARG A 142
 None
 0.92A 3bjwH-5efvA:
undetectable		 3bjwH-5efvA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er7 GAP JUNCTION BETA-2
PROTEIN

(Homo sapiens) 		no annotation 4 VAL B  38
VAL B  37
PHE B 194
ARG B  75
 None
 1.12A 3bjwH-5er7B:
undetectable		 3bjwH-5er7B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 VAL A  18
VAL A  19
GLN A  46
PHE A 300
 None
 1.39A 3bjwH-5firA:
undetectable		 3bjwH-5firA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		4 VAL A 283
VAL A 284
PHE A 237
ARG A 359
 None
 1.22A 3bjwH-5gj3A:
undetectable		 3bjwH-5gj3A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		4 VAL A 262
VAL A 263
PHE A  68
ARG A 222
 None
 1.19A 3bjwH-5gl9A:
undetectable		 3bjwH-5gl9A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 VAL A1348
VAL A1347
GLN A1343
PHE A1274
 None
 1.39A 3bjwH-5gutA:
undetectable		 3bjwH-5gutA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 VAL A 134
VAL A 203
PHE A 211
ARG A 236
 None
 1.18A 3bjwH-5gw8A:
undetectable		 3bjwH-5gw8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyq SPIKE GLYCOPROTEIN

(Rousettus bat
coronavirus
HKU9) 		PF09408
(Spike_rec_bind) 		4 VAL A  22
VAL A  23
PHE A 121
ARG A  26
 None
 0.95A 3bjwH-5gyqA:
undetectable		 3bjwH-5gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF01852
(START) 		4 VAL B 525
VAL B 554
PHE B 583
ARG B 405
 PGE  B 604 ( 4.6A)
None
None
None
 1.35A 3bjwH-5jjdB:
undetectable		 3bjwH-5jjdB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 VAL A 409
VAL A 456
GLN A 401
PHE A 365
 None
 1.24A 3bjwH-5ktkA:
undetectable		 3bjwH-5ktkA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB

(Saccharomyces
cerevisiae) 		no annotation 4 VAL 7 657
GLN 7 672
PHE 7 626
ARG 7 722
 None
 1.09A 3bjwH-5oqm7:
undetectable		 3bjwH-5oqm7:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owj TRIGGER FACTOR

(Escherichia
coli) 		no annotation 4 VAL A 258
GLN A 191
PHE A 252
ARG A 193
 None
 1.15A 3bjwH-5owjA:
undetectable		 3bjwH-5owjA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 VAL A 145
GLN A 269
PHE A 260
ARG A 272
 None
 1.09A 3bjwH-5u39A:
undetectable		 3bjwH-5u39A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 4 VAL B 363
VAL B 364
GLN B 372
PHE B 319
 None
 1.02A 3bjwH-5xyjB:
undetectable		 3bjwH-5xyjB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 VAL A 181
VAL A 182
GLN A 188
PHE A 373
 None
 1.15A 3bjwH-5ybbA:
undetectable		 3bjwH-5ybbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yht HISTIDINOL-PHOSPHATA
SE

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A 201
VAL A 196
PHE A 159
ARG A 227
 None
 1.23A 3bjwH-5yhtA:
1.7		 3bjwH-5yhtA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 4 VAL I 221
VAL I 220
PHE I 224
ARG I 166
 None
 1.34A 3bjwH-6bnpI:
0.2		 3bjwH-6bnpI:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs9 STAGE III
SPORULATION PROTEIN
AB

(Bacillus
subtilis) 		no annotation 4 VAL A  97
GLN A  34
PHE A  75
ARG A  30
 None
 1.27A 3bjwH-6bs9A:
1.6		 3bjwH-6bs9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1q RNA
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		no annotation 4 VAL B 154
VAL B 155
PHE B 100
ARG B  18
 None
 1.38A 3bjwH-6d1qB:
undetectable		 3bjwH-6d1qB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1
STRUCTURAL PROTEIN
VP2

(Sacbrood virus) 		no annotation 4 VAL A 176
GLN B 138
PHE B 134
ARG A 184
 None
 1.34A 3bjwH-6egxA:
undetectable		 3bjwH-6egxA:
undetectable