SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_B_SVRB512

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  37
VAL H  48
THR H  95
ARG H  38
 None
 1.19A 3bjwA-1adqH:
0.0		 3bjwA-1adqH:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fux HYPOTHETICAL 19.5
KDA PROTEIN IN
EMRE-RUS INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 VAL A  67
VAL A  93
THR A 127
THR A  65
 None
 1.00A 3bjwA-1fuxA:
0.0		 3bjwA-1fuxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		4 VAL A 238
THR A 295
THR A 265
ARG A 264
 None
 1.12A 3bjwA-1hjoA:
0.0		 3bjwA-1hjoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id0 PHOQ HISTIDINE
KINASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 VAL A 413
VAL A 412
THR A 348
ARG A 471
 None
 1.12A 3bjwA-1id0A:
0.0		 3bjwA-1id0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 227
VAL A 228
THR A 196
ARG A 225
 None
 1.08A 3bjwA-1m0uA:
0.0		 3bjwA-1m0uA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 198
VAL A 197
THR A  85
THR A 180
 None
None
None
PLP  A 400 ( 4.1A)
 1.05A 3bjwA-1n8pA:
0.0		 3bjwA-1n8pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		4 VAL A  50
THR A 181
THR A 143
ARG A  49
 None
 1.19A 3bjwA-1nqzA:
undetectable		 3bjwA-1nqzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 VAL A 338
VAL A 354
THR A 290
THR A 341
 None
 1.22A 3bjwA-1vrqA:
0.0		 3bjwA-1vrqA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wil KIAA1045 PROTEIN

(Homo sapiens) 		PF16744
(Zf_RING) 		4 VAL A  38
THR A  25
THR A  36
ARG A  37
 None
 1.19A 3bjwA-1wilA:
undetectable		 3bjwA-1wilA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HEAT SHOCK 70 KDA
PROTEIN 1

(Homo sapiens) 		PF00012
(HSP70) 		4 VAL C 238
THR C 295
THR C 265
ARG C 264
 None
 1.19A 3bjwA-1xqsC:
0.0		 3bjwA-1xqsC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		4 VAL A  12
THR A  40
THR A  48
ARG A  15
 None
 1.05A 3bjwA-1ydoA:
undetectable		 3bjwA-1ydoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 VAL A 221
THR A 276
THR A 201
ARG A 220
 None
 1.11A 3bjwA-1ygpA:
undetectable		 3bjwA-1ygpA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpe BPSL1050

(Burkholderia
pseudomallei) 		no annotation 5 VAL A  37
VAL A  38
THR A  15
THR A  35
ARG A  50
 None
 1.46A 3bjwA-2mpeA:
undetectable		 3bjwA-2mpeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 693
VAL A 694
THR A 417
THR A 689
 None
 1.17A 3bjwA-2nq5A:
undetectable		 3bjwA-2nq5A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 VAL A 137
VAL A 134
THR A 118
THR A 132
 None
 0.99A 3bjwA-2pi5A:
undetectable		 3bjwA-2pi5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 VAL A  97
VAL A  98
THR A 254
THR A  95
 None
 1.14A 3bjwA-2q6uA:
undetectable		 3bjwA-2q6uA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 VAL A   2
VAL A   3
THR A  23
THR A  70
 None
 0.71A 3bjwA-2qheA:
22.8		 3bjwA-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL X 209
VAL X 208
THR X 251
ARG X 181
 3BZ  X 505 (-4.9A)
None
None
None
 1.10A 3bjwA-2qvxX:
undetectable		 3bjwA-2qvxX:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 VAL A 238
THR A 295
THR A 265
ARG A 264
 None
 1.04A 3bjwA-2v7zA:
undetectable		 3bjwA-2v7zA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 VAL A 782
VAL A 783
THR A 760
THR A 796
 None
 1.13A 3bjwA-2w92A:
undetectable		 3bjwA-2w92A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL S  65
VAL S  32
THR S  79
THR S  64
 None
 1.08A 3bjwA-2wpmS:
undetectable		 3bjwA-2wpmS:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 VAL A 208
VAL A 209
THR A 221
ARG A 207
 None
 1.17A 3bjwA-2yz2A:
undetectable		 3bjwA-2yz2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbc 83AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR ASNC

(Sulfurisphaera
tokodaii) 		PF01037
(AsnC_trans_reg) 		4 VAL A  42
VAL A  31
THR A  69
THR A  29
 None
None
ILE  A  84 (-3.6A)
None
 1.16A 3bjwA-2zbcA:
undetectable		 3bjwA-2zbcA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 VAL A 394
VAL A 395
THR A 399
ARG A 393
 None
 1.08A 3bjwA-3bb8A:
undetectable		 3bjwA-3bb8A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		4 VAL A 118
VAL A 117
THR A  99
THR A  34
 None
 0.85A 3bjwA-3dtoA:
undetectable		 3bjwA-3dtoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A  81
VAL A  82
THR A 156
THR A  71
 None
 1.16A 3bjwA-3eqqA:
undetectable		 3bjwA-3eqqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
NANOBODY NBGSPD_7

(Escherichia
coli;
Lama glama) 		PF03958
(Secretin_N)
PF07686
(V-set) 		4 VAL A 135
VAL A 134
THR A 156
ARG B 107
 None
 1.18A 3bjwA-3ezjA:
1.8		 3bjwA-3ezjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6z PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09864
(MliC) 		4 VAL B  71
VAL B  81
THR B  44
THR B  79
 None
 1.08A 3bjwA-3f6zB:
undetectable		 3bjwA-3f6zB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 VAL A 489
VAL A 490
THR A 439
THR A 396
 None
 1.06A 3bjwA-3gecA:
undetectable		 3bjwA-3gecA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA'

(Escherichia
coli) 		PF09115
(DNApol3-delta_C)
PF13177
(DNA_pol3_delta2) 		4 VAL E 112
VAL E 111
THR E 131
THR E  78
 None
 1.17A 3bjwA-3glgE:
1.1		 3bjwA-3glgE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A 204
VAL A 192
THR A 234
THR A 202
 None
 1.04A 3bjwA-3hrdA:
undetectable		 3bjwA-3hrdA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 VAL A 391
VAL A 358
THR A 405
ARG A 392
 None
 1.18A 3bjwA-3hs0A:
undetectable		 3bjwA-3hs0A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		4 VAL A 277
VAL A 278
THR A 231
ARG A 310
 None
 1.05A 3bjwA-3ksmA:
0.3		 3bjwA-3ksmA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 594
VAL A 595
THR A 537
THR A 509
 None
 1.21A 3bjwA-3ldrA:
undetectable		 3bjwA-3ldrA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		4 VAL A 280
VAL A 281
THR A 288
THR A 276
 None
 0.85A 3bjwA-3m66A:
undetectable		 3bjwA-3m66A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 VAL A 168
VAL A 167
THR A 189
ARG A 333
 None
 0.90A 3bjwA-3mczA:
undetectable		 3bjwA-3mczA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		4 VAL A 321
VAL A 336
THR A 319
ARG A 320
 None
 1.21A 3bjwA-3nvqA:
undetectable		 3bjwA-3nvqA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A  70
VAL A  71
THR A 470
ARG A 473
 None
 1.13A 3bjwA-3o80A:
undetectable		 3bjwA-3o80A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0c NISCHARIN

(Homo sapiens) 		PF00787
(PX) 		4 VAL A  21
VAL A  22
THR A  31
ARG A  20
 None
 1.12A 3bjwA-3p0cA:
undetectable		 3bjwA-3p0cA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 VAL A  15
VAL A  50
THR A  17
ARG A  16
 None
 1.17A 3bjwA-3pe8A:
undetectable		 3bjwA-3pe8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyr ECHA16_2

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 VAL A  14
VAL A  49
THR A  16
ARG A  15
 None
 1.16A 3bjwA-3qyrA:
undetectable		 3bjwA-3qyrA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		4 VAL A 440
VAL A 439
THR A 295
ARG A 443
 None
None
HEM  A 500 (-3.3A)
None
 0.71A 3bjwA-3qz1A:
undetectable		 3bjwA-3qz1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 VAL A  17
VAL A  18
THR A 233
THR A  40
 None
 1.20A 3bjwA-3rd5A:
undetectable		 3bjwA-3rd5A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 VAL A 378
VAL A 350
THR A 401
THR A 380
 None
 1.04A 3bjwA-3riqA:
undetectable		 3bjwA-3riqA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		4 VAL A 126
VAL A 179
THR A 143
THR A 128
 None
 1.10A 3bjwA-3rq1A:
undetectable		 3bjwA-3rq1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rty PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 VAL A 489
VAL A 490
THR A 439
THR A 396
 None
 0.95A 3bjwA-3rtyA:
undetectable		 3bjwA-3rtyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		4 VAL B 482
THR B 512
THR B 477
ARG B 478
 None
 1.07A 3bjwA-3u44B:
undetectable		 3bjwA-3u44B:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 4 VAL A  64
VAL A  65
THR A  22
ARG A  20
 None
 1.10A 3bjwA-3u9gA:
undetectable		 3bjwA-3u9gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ug7 ARSENICAL
PUMP-DRIVING ATPASE

(Methanocaldococcus
jannaschii) 		PF02374
(ArsA_ATPase) 		4 VAL A  91
VAL A  58
THR A  40
THR A  81
 None
None
MG  A 403 ( 3.2A)
None
 1.17A 3bjwA-3ug7A:
undetectable		 3bjwA-3ug7A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnf MEMBRANE-ASSOCIATED
PROTEIN VP24

(Sudan
ebolavirus) 		PF06389
(Filo_VP24) 		4 VAL A 170
VAL A 169
THR A 191
ARG A 192
 None
 1.17A 3bjwA-3vnfA:
undetectable		 3bjwA-3vnfA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 344
VAL A 345
THR A 342
ARG A 343
 None
 1.22A 3bjwA-3vnsA:
undetectable		 3bjwA-3vnsA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		4 VAL A 149
VAL A 142
THR A 216
ARG A 151
 None
 1.17A 3bjwA-4ac3A:
undetectable		 3bjwA-4ac3A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		4 VAL A 855
VAL A 856
THR A 709
ARG A 854
 None
 1.12A 3bjwA-4b9wA:
undetectable		 3bjwA-4b9wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9x TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		4 VAL A 855
VAL A 856
THR A 709
ARG A 854
 None
 1.07A 3bjwA-4b9xA:
undetectable		 3bjwA-4b9xA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 VAL A 335
VAL A 357
THR A 388
THR A 337
 None
 1.06A 3bjwA-4bjuA:
undetectable		 3bjwA-4bjuA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL A 252
VAL A 253
THR A 554
THR A 248
 None
 1.04A 3bjwA-4cgyA:
undetectable		 3bjwA-4cgyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckn SAS-6

(Leishmania
major) 		PF16531
(SAS-6_N) 		4 VAL A 159
VAL A 175
THR A 137
THR A 161
 None
 1.15A 3bjwA-4cknA:
undetectable		 3bjwA-4cknA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		4 VAL A  53
VAL A  40
THR A  99
THR A  38
 None
 1.04A 3bjwA-4cp6A:
undetectable		 3bjwA-4cp6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 VAL A 205
VAL A 206
THR A 188
THR A 201
 None
 0.88A 3bjwA-4f0sA:
undetectable		 3bjwA-4f0sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9y PCAV TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13463
(HTH_27) 		4 VAL A  69
VAL A  70
THR A  33
THR A  65
 None
 0.96A 3bjwA-4g9yA:
undetectable		 3bjwA-4g9yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 VAL A  66
THR A  58
THR A  70
ARG A  73
 None
 1.14A 3bjwA-4h16A:
undetectable		 3bjwA-4h16A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 VAL A 238
THR A 295
THR A 265
ARG A 264
 None
 0.91A 3bjwA-4hwiA:
undetectable		 3bjwA-4hwiA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.15A 3bjwA-4iyoB:
undetectable		 3bjwA-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 VAL D 114
THR C  53
THR D  99
ARG D 102
 None
 1.20A 3bjwA-4jjnD:
undetectable		 3bjwA-4jjnD:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 VAL A  18
THR A 175
THR A  16
ARG A  15
 None
 1.19A 3bjwA-4l4qA:
undetectable		 3bjwA-4l4qA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio cholerae) 		PF01135
(PCMT) 		4 VAL A  79
VAL A 100
THR A 148
THR A  77
 None
None
SAH  A 301 (-3.4A)
None
 1.18A 3bjwA-4l7vA:
undetectable		 3bjwA-4l7vA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		4 VAL X 172
VAL X 173
THR X 157
THR X 198
 None
 1.19A 3bjwA-4li3X:
undetectable		 3bjwA-4li3X:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		4 VAL A 182
THR A 165
THR A 224
ARG A 226
 None
 1.19A 3bjwA-4n0nA:
undetectable		 3bjwA-4n0nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 310
VAL A 311
THR A 356
THR A 306
 None
None
None
HEM  A 600 ( 3.2A)
 1.17A 3bjwA-4nkyA:
undetectable		 3bjwA-4nkyA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 VAL A 240
VAL A 241
THR A 157
ARG A 234
 None
 1.21A 3bjwA-4nwzA:
undetectable		 3bjwA-4nwzA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 169
THR A 371
THR A 173
ARG A 172
 None
 1.15A 3bjwA-4oqjA:
undetectable		 3bjwA-4oqjA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 VAL A 301
VAL A 315
THR A 224
ARG A 302
 None
 1.21A 3bjwA-4ptxA:
undetectable		 3bjwA-4ptxA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		4 VAL A  51
VAL A  52
THR A 130
THR A  47
 None
 0.98A 3bjwA-4qdkA:
undetectable		 3bjwA-4qdkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 VAL A 122
VAL A 166
THR A  81
THR A 124
 None
 1.05A 3bjwA-4r27A:
undetectable		 3bjwA-4r27A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 VAL A 107
VAL A 108
THR A 182
ARG A 106
 None
 1.16A 3bjwA-4wqmA:
undetectable		 3bjwA-4wqmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		4 VAL B 173
VAL B 174
THR B 110
ARG B 172
 None
None
None
MLY  B 153 ( 3.5A)
 1.12A 3bjwA-4xl1B:
undetectable		 3bjwA-4xl1B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 VAL A  24
VAL A  25
THR A  64
THR A  10
 None
 1.22A 3bjwA-4zfzA:
undetectable		 3bjwA-4zfzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB

(Escherichia
coli) 		PF01458
(UPF0051) 		4 VAL A 269
VAL A 268
THR A 283
ARG A 237
 None
 1.15A 3bjwA-5awfA:
undetectable		 3bjwA-5awfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq3 RHAMNOSE ABC
TRANSPORTER,
RHAMNOSE-BINDING
PROTEIN

(Actinomyces
odontolyticus) 		PF13407
(Peripla_BP_4) 		4 VAL A 334
VAL A 335
THR A 135
THR A 327
 None
 1.22A 3bjwA-5bq3A:
undetectable		 3bjwA-5bq3A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 VAL A 302
VAL A 301
THR A 314
ARG A 303
 None
 1.06A 3bjwA-5cdiA:
undetectable		 3bjwA-5cdiA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 VAL A  40
VAL A  39
THR A  66
ARG A  41
 None
 1.20A 3bjwA-5e7pA:
undetectable		 3bjwA-5e7pA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		4 VAL A 167
VAL A 168
THR A 155
THR A  72
 None
 1.18A 3bjwA-5eogA:
undetectable		 3bjwA-5eogA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 VAL A 816
THR A 761
THR A 843
ARG A 817
 None
 1.20A 3bjwA-5gz4A:
0.9		 3bjwA-5gz4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 261
VAL A 238
THR A 247
ARG A 260
 None
 1.16A 3bjwA-5k1sA:
undetectable		 3bjwA-5k1sA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 4 VAL A 112
VAL A 111
THR A  63
ARG A 113
 CRO  A  66 ( 4.9A)
None
None
None
 1.17A 3bjwA-5mseA:
undetectable		 3bjwA-5mseA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 4 VAL A 101
VAL A 100
THR A 249
THR A 104
 None
 1.16A 3bjwA-5nxnA:
undetectable		 3bjwA-5nxnA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 4 VAL B 531
VAL B 530
THR B 496
ARG B 539
 None
 1.18A 3bjwA-5ochB:
undetectable		 3bjwA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		4 VAL F 397
VAL F 396
THR F  57
THR F 399
 NFU  F 501 (-4.4A)
None
None
NFU  F 501 (-3.7A)
 1.14A 3bjwA-5odrF:
undetectable		 3bjwA-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		4 VAL F 396
VAL F 397
THR E 114
THR F 377
 None
NFU  F 501 (-4.4A)
None
None
 1.21A 3bjwA-5odrF:
undetectable		 3bjwA-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szp PROTOCADHERIN GAMMA
B7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 VAL A 202
VAL A 203
THR A 177
ARG A 201
 None
 1.16A 3bjwA-5szpA:
undetectable		 3bjwA-5szpA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5w INTERFERON LAMBDA
RECEPTOR 1

(Homo sapiens) 		PF01108
(Tissue_fac) 		4 VAL B  80
VAL B  37
THR B  11
THR B  82
 None
 1.15A 3bjwA-5t5wB:
undetectable		 3bjwA-5t5wB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulu CADHERIN-23

(Mus musculus) 		no annotation 4 VAL A2121
VAL A2122
THR A2050
ARG A2084
 None
 1.17A 3bjwA-5uluA:
undetectable		 3bjwA-5uluA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbu CYTOCHROME P450
21-HYDROXYLASE

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 442
VAL A 441
THR A 300
ARG A 445
 None
None
HEM  A 501 (-3.4A)
None
 1.13A 3bjwA-5vbuA:
undetectable		 3bjwA-5vbuA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 4 VAL B 161
VAL B 162
THR B 123
THR B 157
 None
 1.17A 3bjwA-5vqiB:
undetectable		 3bjwA-5vqiB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 VAL A 193
VAL A 262
THR A 201
ARG A 194
 None
 1.17A 3bjwA-5xpgA:
undetectable		 3bjwA-5xpgA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0s THERMOTOGA MARITIMA
TMCAL

(Thermotoga
maritima) 		no annotation 4 VAL A  66
VAL A  67
THR A  93
THR A 343
 None
 1.20A 3bjwA-5y0sA:
undetectable		 3bjwA-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 VAL A 148
THR A 198
THR A 156
ARG A 155
 None
 1.14A 3bjwA-6c66A:
undetectable		 3bjwA-6c66A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejm SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 VAL H  75
VAL H  86
THR H 138
ARG H  76
 None
 1.12A 3bjwA-6ejmH:
undetectable		 3bjwA-6ejmH:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 4 VAL A 166
THR A 179
THR A 306
ARG A 307
 VAL  A 166 ( 0.6A)
THR  A 179 ( 0.8A)
THR  A 306 ( 0.8A)
ARG  A 307 ( 0.6A)
 1.11A 3bjwA-6gefA:
undetectable		 3bjwA-6gefA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 VAL A   7
VAL A  41
THR A 176
THR A   9
 None
 1.18A 3bjwA-6gnfA:
1.5		 3bjwA-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A 183
ILE A 321
GLY A 320
ARG A 325
 None
 0.83A 3bjwB-1as4A:
0.0		 3bjwB-1as4A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		4 VAL P  90
ILE P 212
GLY P 211
ARG P 230
 None
 0.76A 3bjwB-1bruP:
undetectable		 3bjwB-1bruP:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 VAL A 270
LYS A 273
ILE A 276
GLN A 277
 None
 0.71A 3bjwB-1dqzA:
undetectable		 3bjwB-1dqzA:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		4 LYS A   7
GLN A  11
GLY A  15
LEU A 110
 None
 0.73A 3bjwB-1godA:
20.3		 3bjwB-1godA:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 VAL A 317
ILE A 330
GLY A 358
ARG A 382
 None
 0.70A 3bjwB-1kkrA:
undetectable		 3bjwB-1kkrA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 VAL A 372
ILE A 338
GLN A 136
GLY A 337
 None
 0.85A 3bjwB-1kkrA:
undetectable		 3bjwB-1kkrA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 4 VAL B  91
LYS B  93
ILE B  94
GLY B  78
 None
 0.90A 3bjwB-1l1oB:
undetectable		 3bjwB-1l1oB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 VAL B 319
ILE B 248
GLY B 229
ARG B 237
 None
 0.85A 3bjwB-1lwuB:
undetectable		 3bjwB-1lwuB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 VAL A 268
ILE A 275
GLN A 276
GLY A 278
 None
 0.84A 3bjwB-1m9qA:
undetectable		 3bjwB-1m9qA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 LYS A1007
GLN A1011
GLY A1014
ARG A1107
LEU A1110
 None
 0.90A 3bjwB-1mc2A:
21.2		 3bjwB-1mc2A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nui DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF08273
(Prim_Zn_Ribbon)
PF13155
(Toprim_2) 		4 LYS A  88
GLN A  92
GLY A  95
LEU A 146
 None
 0.90A 3bjwB-1nuiA:
undetectable		 3bjwB-1nuiA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 VAL A 216
LYS A 220
ILE A 223
GLY A 226
 None
 0.63A 3bjwB-1o5tA:
undetectable		 3bjwB-1o5tA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		4 VAL D 790
ILE D 912
GLY D 911
ARG D 930
 None
 0.66A 3bjwB-1pytD:
undetectable		 3bjwB-1pytD:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 VAL A 267
ILE A 257
GLY A 214
ARG A 212
 None
 0.84A 3bjwB-1q8kA:
undetectable		 3bjwB-1q8kA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 VAL A 354
LYS A 358
ILE A 361
ARG A 366
 None
 0.68A 3bjwB-1qh4A:
undetectable		 3bjwB-1qh4A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 VAL A 130
ILE A 115
GLY A  78
LEU A  85
 None
 0.82A 3bjwB-1qh5A:
undetectable		 3bjwB-1qh5A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 VAL A 216
LYS A 220
ILE A 223
GLY A 226
 None
 0.75A 3bjwB-1r6uA:
undetectable		 3bjwB-1r6uA:
12.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		4 GLN A  11
GLY A  14
ARG A 107
LEU A 110
 None
 0.48A 3bjwB-1s8hA:
20.6		 3bjwB-1s8hA:
62.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR

(Geobacillus
stearothermophilus) 		PF01895
(PhoU) 		4 VAL A  98
LYS A 102
ILE A 105
GLY A 108
 None
 0.75A 3bjwB-1xwmA:
undetectable		 3bjwB-1xwmA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A 131
ILE A 138
GLN A 139
GLY A 141
 None
 0.82A 3bjwB-1yv9A:
undetectable		 3bjwB-1yv9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 VAL A 166
LYS A 164
ILE A 163
GLY A 152
 None
 0.83A 3bjwB-2ahwA:
undetectable		 3bjwB-2ahwA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ILE A1037
GLN A  10
GLY A1038
LEU A1000
 None
 0.59A 3bjwB-2b5mA:
undetectable		 3bjwB-2b5mA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdv PHAGE-RELATED
CONSERVED
HYPOTHETICAL
PROTEIN, BB2244

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		4 VAL A  49
ILE A  95
GLY A 131
LEU A 191
 None
 0.65A 3bjwB-2bdvA:
undetectable		 3bjwB-2bdvA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlz PROTEIN VAV-2

(Homo sapiens) 		PF00017
(SH2) 		4 VAL A  68
LYS A  66
ILE A  65
LEU A  32
 None
 0.85A 3bjwB-2dlzA:
undetectable		 3bjwB-2dlzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 ILE B 470
GLN B 474
GLY B 469
LEU B 509
 None
 0.70A 3bjwB-2fffB:
undetectable		 3bjwB-2fffB:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 VAL A  35
LYS A  39
ILE A  42
GLY A  45
 None
 0.89A 3bjwB-2fvlA:
undetectable		 3bjwB-2fvlA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 LYS A   3
ILE A  20
GLN A  21
LEU A 344
 None
 0.87A 3bjwB-2i1jA:
undetectable		 3bjwB-2i1jA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 VAL A 432
ILE A 544
GLY A 543
ARG A 541
 None
 0.87A 3bjwB-2ipcA:
undetectable		 3bjwB-2ipcA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00579
(tRNA-synt_1b) 		4 ILE A  30
GLN A  64
GLY A  62
LEU A   8
 ILE  A  30 ( 0.7A)
GLN  A  64 ( 0.6A)
GLY  A  62 ( 0.0A)
LEU  A   8 ( 0.6A)
 0.88A 3bjwB-2j5bA:
undetectable		 3bjwB-2j5bA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 VAL A 176
ILE A 183
GLN A 184
GLY A 187
 None
 0.87A 3bjwB-2pcuA:
undetectable		 3bjwB-2pcuA:
16.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		5 LYS A   7
GLN A  11
GLY A  15
ARG A 107
LEU A 110
 None
 1.12A 3bjwB-2ph4A:
19.4		 3bjwB-2ph4A:
57.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1d 2-KETO-3-DEOXY-D-ARA
BINONATE DEHYDRATASE

(Sulfolobus
solfataricus) 		PF01557
(FAA_hydrolase) 		4 VAL X 148
ILE X 279
GLY X 280
LEU X  57
 None
 0.89A 3bjwB-2q1dX:
undetectable		 3bjwB-2q1dX:
16.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		6 LYS A   7
ILE A  10
GLN A  11
GLY A  14
ARG A 107
LEU A 110
 None
 0.61A 3bjwB-2qheA:
24.1		 3bjwB-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		6 VAL A   3
ILE A  10
GLN A  11
GLY A  14
ARG A 107
LEU A 110
 None
 0.51A 3bjwB-2qheA:
24.1		 3bjwB-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A 101
LYS A 105
ILE A 108
GLY A 111
 None
 0.88A 3bjwB-2vgiA:
undetectable		 3bjwB-2vgiA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd4 KV
CHANNEL-INTERACTING
PROTEIN 4

(Mus musculus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 VAL A  16
LYS A  20
GLN A  24
GLY A  26
 None
 0.74A 3bjwB-3dd4A:
undetectable		 3bjwB-3dd4A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 155
ILE A 327
GLY A 289
ARG A 161
 None
 0.83A 3bjwB-3dh9A:
undetectable		 3bjwB-3dh9A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fb4 ADENYLATE KINASE

(Jeotgalibacillus
marinus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 VAL A  90
ILE A  65
GLY A  66
LEU A  45
 None
 0.77A 3bjwB-3fb4A:
undetectable		 3bjwB-3fb4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdu PUTATIVE
THIOESTERASE

(Syntrophus
aciditrophicus) 		PF03061
(4HBT) 		4 VAL A 119
ILE A  65
GLY A  62
ARG A  58
 None
 0.87A 3bjwB-3hduA:
undetectable		 3bjwB-3hduA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 VAL A 322
LYS A 326
ILE A 329
GLY A 333
 None
 0.73A 3bjwB-3i6rA:
undetectable		 3bjwB-3i6rA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		4 LYS A  83
ILE A  86
GLN A  87
LEU A 306
 None
 0.76A 3bjwB-3kgwA:
undetectable		 3bjwB-3kgwA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A  69
ILE A  12
ARG A 117
LEU A  30
 None
 0.86A 3bjwB-3kkjA:
undetectable		 3bjwB-3kkjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Sulfolobus
solfataricus) 		no annotation 4 VAL C 188
ILE C 127
GLY C 149
LEU C 120
 None
 0.85A 3bjwB-3l7zC:
undetectable		 3bjwB-3l7zC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ILE A 261
GLN A 262
GLY A 264
LEU A 203
 None
 0.85A 3bjwB-3ln3A:
undetectable		 3bjwB-3ln3A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
2) 		PF05259
(Herpes_UL1)
PF12524
(GlyL_C) 		4 VAL B  61
ILE B  67
GLY B  69
ARG B  86
 None
 0.85A 3bjwB-3m1cB:
undetectable		 3bjwB-3m1cB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o52 GDP-MANNOSE
PYROPHOSPHATASE NUDK

(Escherichia
coli) 		PF00293
(NUDIX) 		4 VAL A  95
LYS A  99
ILE A 102
GLY A 106
 None
 0.70A 3bjwB-3o52A:
undetectable		 3bjwB-3o52A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A  34
LYS A  38
ILE A  41
GLY A  44
 None
 0.87A 3bjwB-3pp7A:
undetectable		 3bjwB-3pp7A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		4 LYS A 214
ILE A 217
GLY A 220
LEU A 179
 None
 0.90A 3bjwB-3pxgA:
undetectable		 3bjwB-3pxgA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LYS A 214
ILE A 217
GLY A 220
LEU A 179
 None
 0.90A 3bjwB-3pxiA:
undetectable		 3bjwB-3pxiA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 4 VAL A  27
ILE A  69
GLN A  71
LEU A  62
 None
 0.73A 3bjwB-3qkwA:
undetectable		 3bjwB-3qkwA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 VAL B 565
GLN B 560
GLY B 575
LEU B 611
 None
 0.91A 3bjwB-3s4wB:
undetectable		 3bjwB-3s4wB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 VAL A  16
GLN A 229
GLY A 267
ARG A 265
 None
 0.84A 3bjwB-3ssmA:
undetectable		 3bjwB-3ssmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1
UBIQUITIN-LIKE
PROTEIN
SMT3,RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Saccharomyces
cerevisiae;
Schizosaccharomyces
pombe) 		PF11976
(Rad60-SLD)
no annotation 		4 VAL A  66
ILE A   6
GLY A   7
LEU B 655
 None
CL  A1003 (-4.1A)
None
None
 0.68A 3bjwB-3tixA:
undetectable		 3bjwB-3tixA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09704
(Cas_Cas5d) 		4 VAL A  94
ILE A  43
GLY A  42
ARG A  37
 None
 0.89A 3bjwB-3vzhA:
undetectable		 3bjwB-3vzhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 VAL A 624
ILE A 574
GLY A 573
LEU A 603
 None
 0.66A 3bjwB-3wajA:
2.0		 3bjwB-3wajA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE

(Fusobacterium
nucleatum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 112
ILE A 231
GLY A 256
LEU A 250
 None
None
GOL  A 405 ( 3.8A)
None
 0.76A 3bjwB-3wwyA:
undetectable		 3bjwB-3wwyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zie SEPF-LIKE PROTEIN

(Archaeoglobus
fulgidus) 		PF04472
(SepF) 		4 VAL A  50
LYS A  54
ILE A  57
GLY A  60
 None
 0.74A 3bjwB-3zieA:
undetectable		 3bjwB-3zieA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zri CLPB PROTEIN

(Vibrio cholerae) 		PF02861
(Clp_N) 		4 VAL A  92
ILE A 116
GLY A 114
LEU A 144
 None
 0.88A 3bjwB-3zriA:
undetectable		 3bjwB-3zriA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		4 VAL X 487
ILE X 461
GLY X 460
ARG X 458
 None
 0.84A 3bjwB-3zyyX:
undetectable		 3bjwB-3zyyX:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 VAL A 698
ILE A 503
GLY A 504
LEU A 448
 None
 0.76A 3bjwB-4av6A:
1.1		 3bjwB-4av6A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		4 VAL A 154
ILE A 151
GLY A  94
LEU A  68
 None
 0.88A 3bjwB-4cr6A:
undetectable		 3bjwB-4cr6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		4 VAL A 249
ILE A 252
GLY A 274
LEU A 262
 None
 0.89A 3bjwB-4exqA:
undetectable		 3bjwB-4exqA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL A  90
ILE A 212
GLY A 211
ARG A 230
 None
 0.75A 3bjwB-4h4fA:
undetectable		 3bjwB-4h4fA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnh GAG POLYPROTEIN

(Simian foamy
virus) 		PF03276
(Gag_spuma) 		4 VAL A  18
ILE A  36
GLY A  37
ARG A  39
 None
 0.87A 3bjwB-4jnhA:
undetectable		 3bjwB-4jnhA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 VAL A 248
ILE A 180
GLY A 181
ARG A 102
 None
 0.78A 3bjwB-4m9xA:
undetectable		 3bjwB-4m9xA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 VAL A  90
ILE A  19
GLY A 354
ARG A 356
 None
 0.91A 3bjwB-4nesA:
undetectable		 3bjwB-4nesA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omj SEC14-LIKE PROTEIN 2

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 VAL A 239
ILE A 258
GLY A  87
LEU A 131
 None
 0.81A 3bjwB-4omjA:
undetectable		 3bjwB-4omjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 VAL A 845
ILE A 939
GLY A 938
LEU A 627
 None
 0.90A 3bjwB-4q2cA:
2.4		 3bjwB-4q2cA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 VAL A 273
LYS A 277
ILE A 280
GLY A 283
 None
 0.83A 3bjwB-4rnwA:
undetectable		 3bjwB-4rnwA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 VAL A  23
LYS A  27
ILE A  30
GLY A  33
 None
 0.83A 3bjwB-4rnxA:
undetectable		 3bjwB-4rnxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 VAL A 203
LYS A 207
ILE A 210
GLY A 214
 None
 0.75A 3bjwB-4rsmA:
undetectable		 3bjwB-4rsmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 VAL A 239
ILE A 258
GLY A  87
LEU A 131
 None
None
None
EDO  A 513 ( 4.1A)
 0.87A 3bjwB-4tlgA:
undetectable		 3bjwB-4tlgA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Agrobacterium
vitis) 		PF01048
(PNP_UDP_1) 		4 VAL A 254
LYS A 258
ILE A 261
GLY A 264
 None
 0.87A 3bjwB-4uc0A:
undetectable		 3bjwB-4uc0A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 106
GLN A 110
GLY A 105
LEU A 330
 None
 0.77A 3bjwB-4uuoA:
undetectable		 3bjwB-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  85
ILE A 106
GLY A 105
LEU A 330
 None
 0.69A 3bjwB-4uuoA:
undetectable		 3bjwB-4uuoA:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LYS A   7
GLN A  11
GLY A  14
ARG A  97
LEU A 100
 None
 0.65A 3bjwB-4wtbA:
21.4		 3bjwB-4wtbA:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		4 VAL A 165
ILE A 119
GLN A 103
GLY A 120
 None
 0.87A 3bjwB-4wwvA:
undetectable		 3bjwB-4wwvA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yd8 PROTEIN PTHB1

(Homo sapiens) 		PF14727
(PHTB1_N) 		4 VAL A 318
ILE A 305
GLY A 306
LEU A 326
 None
 0.82A 3bjwB-4yd8A:
undetectable		 3bjwB-4yd8A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		4 VAL A  34
ILE A  78
GLY A  76
ARG A  73
 None
 0.83A 3bjwB-4z0tA:
undetectable		 3bjwB-4z0tA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay9 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 VAL A 232
ILE A 164
GLY A 142
ARG A 131
 None
 0.69A 3bjwB-5ay9A:
undetectable		 3bjwB-5ay9A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 VAL B  84
ILE B  33
GLY B  32
ARG B  29
 None
 0.76A 3bjwB-5b47B:
undetectable		 3bjwB-5b47B:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 VAL A 515
LYS A 517
ARG A 529
LEU A 530
 None
 0.88A 3bjwB-5by3A:
undetectable		 3bjwB-5by3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		4 VAL A  38
LYS A  42
ILE A  45
GLY A  48
 None
 0.84A 3bjwB-5danA:
undetectable		 3bjwB-5danA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 299
ILE A 304
GLN A 306
GLY A 434
 None
 0.69A 3bjwB-5elxA:
undetectable		 3bjwB-5elxA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 LYS A  61
ILE A  64
GLN A  65
LEU A 284
 None
 0.88A 3bjwB-5f9sA:
undetectable		 3bjwB-5f9sA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		4 VAL A 140
GLN A 175
GLY A 177
ARG A 173
 None
 0.89A 3bjwB-5fclA:
undetectable		 3bjwB-5fclA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 VAL A 638
LYS A 642
ILE A 645
GLN A 646
 None
SO4  A1791 (-3.1A)
None
SO4  A1791 (-3.7A)
 0.56A 3bjwB-5firA:
undetectable		 3bjwB-5firA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ILE A1037
GLN A  10
GLY A1038
LEU A1000
 None
 0.61A 3bjwB-5fqdA:
undetectable		 3bjwB-5fqdA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 156
ILE A 344
GLY A 314
ARG A 309
 None
 0.82A 3bjwB-5jw6A:
undetectable		 3bjwB-5jw6A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		4 VAL A 268
GLN A 418
GLY A 416
LEU A 156
 None
 0.89A 3bjwB-5l35A:
undetectable		 3bjwB-5l35A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 4 ILE A 876
GLN A 877
GLY A 872
ARG A 867
 None
 0.79A 3bjwB-5nprA:
undetectable		 3bjwB-5nprA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 VAL 6 589
ILE 6 547
GLY 6 546
LEU 6 806
 None
 0.78A 3bjwB-5udb6:
undetectable		 3bjwB-5udb6:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF12213
(Dpoe2NT) 		4 VAL A 420
ILE A 445
GLY A 449
LEU A 137
 None
 0.90A 3bjwB-5vbnA:
undetectable		 3bjwB-5vbnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW

(Bacillus
subtilis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 VAL A 166
LYS A 170
ILE A 173
GLY A 176
 None
 0.89A 3bjwB-5wuqA:
2.2		 3bjwB-5wuqA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 4 VAL A   3
GLY A  14
ARG A  98
LEU A 101
 None
None
None
TRS  A 211 (-4.0A)
 0.53A 3bjwB-5wzmA:
20.3		 3bjwB-5wzmA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 VAL A 496
ILE A 523
GLY A 524
ARG A 527
 None
 0.86A 3bjwB-5ze4A:
undetectable		 3bjwB-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 4 VAL A   3
GLN A  11
GLY A  15
ARG A 107
 None
 0.58A 3bjwB-6ce2A:
20.6		 3bjwB-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el1 YAXB

(Yersinia
enterocolitica) 		no annotation 4 VAL O 197
LYS O 201
ILE O 204
GLY O 207
 None
 0.75A 3bjwB-6el1O:
undetectable		 3bjwB-6el1O:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 262
ILE A 269
GLN A 270
LEU A 198
 None
 0.68A 3bjwB-6fnuA:
undetectable		 3bjwB-6fnuA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gw5 -

(-) 		no annotation 4 VAL A  43
LYS A  47
ILE A  50
GLN A  51
 None
 0.74A 3bjwB-6gw5A:
undetectable		 3bjwB-6gw5A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
LYS A 105
TYR A 107
 None
 0.68A 3bjwG-1gmzA:
19.7		 3bjwG-1gmzA:
57.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
ASN A 114
TYR A 117
PRO A 121
 None
 1.04A 3bjwG-1godA:
19.9		 3bjwG-1godA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
TYR A 117
PRO A 121
PHE A 124
 None
 0.95A 3bjwG-1q6vA:
22.0		 3bjwG-1q6vA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
ASN A 114
LYS A 115
TYR A 117
 None
 0.76A 3bjwG-1s8hA:
20.3		 3bjwG-1s8hA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
LYS A 115
TYR A 117
PRO A 121
 None
 0.79A 3bjwG-1vipA:
21.1		 3bjwG-1vipA:
49.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 LYS A  16
TYR A 113
LYS A 116
TYR A 117
PRO A 121
 None
 1.45A 3bjwG-2qheA:
22.6		 3bjwG-2qheA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
LYS A 105
TYR A 107
 None
 0.81A 3bjwG-3dihA:
21.9		 3bjwG-3dihA:
64.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
LYS A 105
TYR A 107
 None
None
None
None
SO4  A 203 (-4.4A)
 0.81A 3bjwG-4wtbA:
20.5		 3bjwG-4wtbA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LYS A  15
TYR A 103
ASN A 104
TYR A 107
PHE A 114
 None
None
None
SO4  A 203 (-4.4A)
None
 0.97A 3bjwG-4wtbA:
20.5		 3bjwG-4wtbA:
56.56